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Colon cancer natural course

Sachin Goyal, Pratima Nangia-Makker, Lulu Farhana, Yingjie Yu, Adhip Pn Majumdar
Over the past two decades there has been remarkable progress in cancer diagnosis, treatment and screening. The basic mechanisms leading to pathogenesis of various types of cancers are also understood better and some patients, if diagnosed at a particular stage go on to lead a normal pre-diagnosis life. Despite these achievements, racial disparity in some cancers remains a mystery. The higher incidence, aggressiveness and mortality of breast, prostate and colorectal cancers (CRCs) in African-Americans as compared to Caucasian-Americans are now well documented...
September 26, 2016: World Journal of Stem Cells
Yasuo Uno, Kenji Tsuboi, Mitsuya Shimizu, Toshihide Tomosugi, Michita Shoka, Soki Hibino, Hidenobu Matsushita, Takuji Takahashi, Osamu Okochi, Yoshihisa Kawase
A73 -year-old man underwent a sigmoidectomy for sigmoid colon cancer with liver metastasis. After the operation, he received CapeOX combined with bevacizumab therapy. After 6 courses, the liver metastasis was undetectable on computed tomography scans. After 15 courses, computed tomography revealed ascites, and chemotherapy was discontinued. Two months later, computed tomography revealed portal vein thrombosis. Owing to the chronic nature of the thrombosis, thrombolytic therapy was not initiated. However, preservation therapy using antiplatelet drugs for 1 month resolved the ascites and the thrombosis...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Takeharu Yamanaka, Eiji Oki, Kentaro Yamazaki, Kensei Yamaguchi, Kei Muro, Hiroyuki Uetake, Takeo Sato, Tomohiro Nishina, Masataka Ikeda, Takeshi Kato, Akiyoshi Kanazawa, Tetsuya Kusumoto, Calvin Chao, Margarita Lopatin, Jayadevi Krishnakumar, Helen Bailey, Kiwamu Akagi, Atsushi Ochiai, Atsushi Ohtsu, Yasuo Ohashi, Takayuki Yoshino
PURPOSE: The 12-gene Recurrence Score assay has been validated in resected stage II colon cancer treated with or without chemotherapy and resected stage III disease treated with chemotherapy. This study evaluated the 12-gene Recurrence Score assay for stage II and III colon cancer without chemotherapy to reveal the natural course of recurrence risk in stage III disease. METHODS: A cohort-sampling design was used. From 1,487 consecutive patients with stage II to III disease who had surgery alone, 630 patients were sampled for inclusion with a 1:2 ratio of recurrence and nonrecurrence...
August 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Monika Bhardwaj, Na-Hyung Kim, Souren Paul, Rekha Jakhar, Jaehong Han, Sun Chul Kang
Plant-derived compounds are an important source of clinically useful anti-cancer agents. Chrysin, a biologically active flavone found in many plants, has limited usage for cancer chemotherapeutics due to its poor oral bioavailability. 5-Hydroxy-7-methoxyflavone (HMF), an active natural chrysin derivative found in various plant sources, is known to modulate several biological activities. However, the mechanism underlying HMF-induced apoptotic cell death in human colorectal carcinoma cells in vitro is still unknown...
2016: PloS One
Sudhir Srivastava, Brian J Reid, Sharmistha Ghosh, Barnett S Kramer
Many cancers offer an extended window of opportunity for early detection and therapeutic intervention that could lead to a reduction in cause-specific mortality. The pursuit of early detection in screening settings has resulted in decreased incidence and mortality for some cancers (e.g., colon and cervical cancers), and increased incidence with only modest or no effect on cause-specific mortality in others (e.g., breast and prostate). Whereas highly sensitive screening technologies are better at detecting a number of suspected "cancers" that are indolent and likely to remain clinically unimportant in the lifetime of a patient, defined as overdiagnosis, they often miss cancers that are aggressive and tend to present clinically between screenings, known as interval cancers...
September 2016: Journal of Cellular Physiology
Małgorzata Kapral, Stanisław Sośnicki, Joanna Wawszczyk, Ludmiła Węglarz
The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1β-stimulated intestinal cancer cell line Caco-2. Quantification of genes expression was carried out using real time RT-QPCR technique in Caco-2 cells after treatment with IL-1β, 1 and 2.5 mM of IP6 for 3, 6 and 12 h. In separate cultures, cells were incubated with IL-1β for the indicated times. The untreated Caco-2 cells were used as the control...
November 2014: Acta Poloniae Pharmaceutica
Atsushi Ikai, Hitoshi Fujiwara, Atsushi Shiozaki, Kazuma Okamoto, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Daisuke Ichikawa, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Toshiya Ochiai, Chouhei Sakakura, Eigo Otsuji
The patient was a 48-year-old woman who was diagnosed with early gastric cancer during a long-term follow-up period for Gardner syndrome. Subtotal colectomy for colon leiomyoma was performed when the patient was 22 years old. Partial resection of the ileum was performed for ileum leiomyoma at the age of 27. Total resection of the remaining colon with ileostomy was performed for a pelvic desmoid tumor at the age of 40. In addition, resection of a desmoid tumor of the abdominal wall was performed 8 times in the 25 years since the first operation...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hyun Jung Kim, Hoo Jae Hann, Sung No Hong, Kyoung Hoon Kim, Il Min Ahn, Ji Yang Song, Sang Hyuk Lee, Hyeong Sik Ahn
BACKGROUND: Although a rising trend in the incidence of inflammatory bowel disease (IBD) in Asia has been recognized, national-level, population-based studies are lacking. In this study, we investigate the epidemiological features and natural course of IBD in Korea, including incidence, bowel resection rates, survival, and cause of death. METHODS: We analyzed the Rare Intractable Disease registration and Health Insurance Review and Assessment Services claims database, which include information on every patients with IBD diagnosed through uniform criteria from 2006 to 2012...
March 2015: Inflammatory Bowel Diseases
Laurent Beaugerie
Crohn's disease may involve any part of the digestive tract from mouth to anus, but affects mainly the distal ileum and the,colon. At diagnosis, perianal lesions are observed in 20% of the cases. During the disease course, strictures develop in the majority of patients with ileal disease, while penetrating lesions (fistulas and abscesses) develop in half of the patients. Only one third of patients with colonic involvement will develop structuring or penetrating lesions. Intestinal lesions of ulcerative colitis involve constantly the rectum and may extend continuously throughout the colon...
November 2014: La Revue du Praticien
Muhammad Imran Aslam, Samir Hussein, Kevin West, Baljit Singh, John Stuart Jameson, James Howard Pringle
INTRODUCTION: Colorectal cancer is the third most common neoplasm worldwide. The sequential progression of colorectal cancer from adenoma to carcinoma highlights that opportunities exist to alter the natural course of disease progression. The aim of this study was to characterize the expression levels of microRNAs linked to development and progression of colorectal neoplasia. Patient, Design, Patients & Methods: MicroRNA expression signature was developed for RNA extracted from freshly frozen tumour and adjacent normal tissue (n = 5)...
January 2015: International Journal of Surgery
Sally E Dickinson, Jadrian J Rusche, Sergiu L Bec, David J Horn, Jaroslav Janda, So Hyun Rim, Catharine L Smith, G Timothy Bowden
Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. Here, we examine for the first time the potential for sulforaphane to inhibit HDACs in HaCaT keratinocytes and compare our results with those found using HCT116 colon cancer cells. Significant inhibition of HDAC activity in HCT116 nuclear extracts required prolonged exposure to sulforaphane in the presence of serum. Under the same conditions HaCaT nuclear extracts did not exhibit reduced HDAC activity with sulforaphane treatment...
November 2015: Molecular Carcinogenesis
Geir Hoff
Less than 5% of colorectal adenomas will become malignant, but we do not have sufficient knowledge about their natural course to target removal of these 5% only. Thus, 95% of polypectomies are a waste of time exposing patients to a small risk of complications. Recently, a new type of polyps, sessile serrated polyps, has attracted attention. Previously considered innocuous, they are now found to have molecular similarities to cancer and some guidelines recommend to have them removed. These lesions are often flat, covered by mucous, not easily seen and situated in the proximal colon where the bowel wall is thinner...
December 14, 2013: World Journal of Gastroenterology: WJG
Baskar Subramani, Kananathan Ratnavelu, Chithra Ramanathan Pullai, Kohila Krishnan, Sheela Devi Sugadan, Xuewen Deng, Terunuma Hiroshi
Current modalities of cancer treatment, including surgery, chemotherapy and radiotherapy, show marginal therapeutic responses in cancer patients. In adoptive immunotherapy, interleukin-2 (IL-2) activated immune cells demonstrated notable results in patients with advanced malignant disease. The present study reports the efficacy and safety of repetitive infusions of autologous immune enhancement therapy (AIET) in a stage IV colonic cancer patient who had already received first-line chemotherapeutic drugs. Peripheral blood was aspirated from the patient...
May 2013: Oncology Letters
Kelly L Harris, Jeremy N Myers, Aramandla Ramesh
Our environment is contaminated with a diverse array of chemicals; one of which is polycyclic aromatic hydrocarbons (PAHs). While some PAHs are potent by nature, others undergo interactions such as additivity, synergism, antagonism or potentiation to manifest their toxicity. Therefore, the objective of this study was to investigate whether exposure to benzo(a)pyrene (BaP), a PAH compound influences the cytotoxicity and metabolism of fluoranthene (FLA; another PAH compound) using HT-29 cells. Cells cultured in Dulbecco's Modified Eagle Medium were treated with 1, 5, 10, 25μM BaP and FLA (0...
September 2013: Environmental Toxicology and Pharmacology
Mi-Kyung Sung, Mi-Young Park
Ulcerative colitis (UC) is an inflammation-associated disease of the colon and rectum. The onset and progress of the disease are directly influenced by the nature of the intestinal microflora, the intestinal barrier function, and the immunological responses of the host. The epithelial invasion of pathogenic bacteria due to excess contact and/or barrier dysfunction is related to inflammation mediated by intestinal immune responses. Although the etiology of UC is not clearly understood, recent studies have shown a rising incidence of UC worldwide, and this phenomenon is more prominent in Asian countries and in Asian immigrants in Western countries...
February 21, 2013: World Journal of Gastroenterology: WJG
Camille Zallot, Laurent Peyrin-Biroulet
Crohn's disease is a chronic, progressive, destructive disease. Complicated disease can be defined as the presence of bowel damage (stricture, abscess or fistula) and/or the need for surgery. Natural history studies provide invaluable data on the disease course. In population-based cohorts, half of all patients experienced an intestinal complication within 20 years after diagnosis and half of the patients required surgery within 10 years after diagnosis. In Olmsted County, the factors associated with the development of complications were the presence of ileal involvement and perianal disease...
2012: Digestive Diseases
Terence C Chua, Chanel H Chong, Winston Liauw, David L Morris
Rectal cancer is a distinct subset of colorectal cancer where specialized disease-specific management of the primary tumor is required. There have been significant developments in rectal cancer surgery at all stages of disease in particular the introduction of local excision strategies for preinvasive and early cancers, standardized total mesorectal excision for resectable cancers incorporating preoperative short- or long-course chemoradiation to the multimodality sequencing of treatment. Laparoscopic surgery is also increasingly being adopted as the standard rectal cancer surgery approach following expertise of colorectal surgeons in minimally invasive surgery gained from laparoscopic colon resections...
2012: International Journal of Surgical Oncology
Al B Barqawi, Kevin J Krughoff, Khadijah Eid
Among men, prostate cancer has a high prevalence, with relatively lower cancer-specific mortality risk compared to lung and colon cancer. Prostate-specific antigen (PSA) screening has increased prostate cancer awareness since its implementation as a screening tool almost 25 years ago, but, due to the largely indolent course of this disease and the unspecific nature of the PSA test, increased incidence has largely been associated with cancers that would not go on to cause death (clinically insignificant), leading to an overdiagnosis challenge and an ensuing overtreatment consequences...
2012: Advances in Urology
Mohammed Al Fadda, Musthafa Chalikandy Peedikayil, Ingvar Kagevi, Khalid Al Kahtani, Ali Al Ben, Hamad Ibrahim Al, Fahad Al Sohaibani, Mohammed Al Quaiz, Maheeba Abdulla, Mohammed Qaseem Khan, Ahmed Helmy
BACKGROUND AND OBJECTIVES: The epidemiology, clinical characteristics, and natural course of inflammatory bowel disease (IBD) in Saudi Arabia are still largely unknown. Hence, we decided to conduct a large retrospective, cohort study to determine these features of the disease. DESIGN AND SETTING: Retrospective study conducted in a tertiary care hospital in Riyadh from January 1970 to December 2008. PATIENTS AND METHODS: We reviewed all the cases of IBD diagnosed and collected all data pertaining to patients with IBD...
May 2012: Annals of Saudi Medicine
Russell O Bainer, Jennifer Taylor Veneris, S Diane Yamada, Anthony Montag, Mark W Lingen, Yoav Gilad, Carrie W Rinker-Schaeffer
Although metastasis is the most lethal attribute of cancer, critical gaps in our knowledge of how cancer cells effectively colonize distant sites remain. For example, little is known about the cellular and molecular events that occur during the timecourse of metastatic colonization. To address this we are using the mitogen-activated protein kinase kinase 4 (MKK4) metastasis suppressor as a tool to identify these events. Specifically, we report a microarray expression-based strategy to identify genes whose transcription is altered in SKOV3ip...
June 2012: Clinical & Experimental Metastasis
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