Toshiki Morimoto, Hiroto Izumi, Taisuke Tomonaga, Chinatsu Nishida, Naoki Kawai, Yasuyuki Higashi, Ke-Yong Wang, Ryohei Ono, Kazuki Sumiya, Kazuo Sakurai, Akihiro Moriyama, Jun-Ichi Takeshita, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto
Polyacrylic acid (PAA), an organic chemical, has been used as an intermediate in the manufacture of pharmaceuticals and cosmetics. It has been suggested recently that PAA has a high pulmonary inflammatory and fibrotic potential. Although endoplasmic reticulum stress is induced by various external and intracellular stimuli, there have been no reports examining the relationship between PAA-induced lung injury and endoplasmic reticulum stress. F344 rats were intratracheally instilled with dispersed PAA (molecular weight: 269,000) at low (0...
March 22, 2024: International Journal of Molecular Sciences