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Neuroprotective effect

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https://www.readbyqxmd.com/read/29223591/mild-hypothermia-protects-hippocampal-neurons-from-oxygen-glucose-deprivation-injury-through-inhibiting-caspase-3-activation
#1
Tianen Zhou, Hui Lin, Longyuan Jiang, Tao Yu, Chaotao Zeng, Juanhua Liu, Zhengfei Yang
Mild hypothermia (MH) is thought to be one of the most effective therapeutic methods to treat hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). However, its precise mechanisms remain unclear. In this research, hippocampal neurons were cultured and treated with mild hypothermia and Ac-DEVD-CHO after oxygen-glucose deprivation (OGD). The activity of caspase-3 was detected, in order to find the precise concentration of Ac-DEVD-CHO with the same protective role in OGD injury as MH treatment. Western blot and immunofluorescence staining were conducted to analyze the effects of MH and Ac-DEVD-CHO on the expressions of caspase-3, caspase-8, and PARP...
December 6, 2017: Cryobiology
https://www.readbyqxmd.com/read/29223528/glp-1-receptor-agonists-downregulate-aberrant-gnt-iii-expression-in-alzheimer-s-disease-models-through-the-akt-gsk-3%C3%AE-%C3%AE-catenin-signaling
#2
Ying Wang, Song Chen, Zheng Xu, Suting Chen, Wenbing Yao, Xiangdong Gao
Alterations of glycoprotein glycans contribute to a wide variety of diseases. Bisecting N-acetylglucosamine (GlcNAc) levels increased in the cerebrospinal fluid of most Alzheimer's disease (AD) patients, and the mRNA levels of N-acetylglucosaminyltransferase III (GnT-III), a glycosyltransferase responsible for synthesizing a bisecting GlcNAc residue, were found highly expressed in the brains of AD patients. In our previous studies, glucagon-like peptide-1 (GLP-1) and its mimetics showed neuroprotective effects...
December 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29223163/neuroprotective-properties-of-endocannabinoids-n-arachidonoyl-dopamine-and-n-docosahexaenoyl-dopamine-examined-in-neuronal-precursors-derived-from-human-pluripotent-stem-cells
#3
E V Novosadova, E L Arsenyeva, E S Manuilova, L G Khaspekov, M Yu Bobrov, V V Bezuglov, S N Illarioshkin, I A Grivennikov
Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine (NADA) and N-docosahexaenoyl dopamine (DHDA) were examined in neuronal precursor cells differentiated from human induced pluripotent stem cells and subjected to oxidative stress. Both compounds exerted neuroprotective activity, which was enhanced by elevating the concentration of the endocannabinoids within the 0.1-10 µM range. However, both agents at 10 µM concentration showed a marked toxic effect resulting in death of ~30% of the cells...
November 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29223124/activation-of-mitochondrial-katp-channels-mediates-neuroprotection-induced-by-chronic-morphine-preconditioning-in-hippocampal-ca-1-neurons-following-cerebral-ischemia
#4
Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
PURPOSE: Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29222946/triheptanoin-protects-against-status-epilepticus-induced-hippocampal-mitochondrial-dysfunctions-oxidative-stress-and-neuronal-degeneration
#5
Kah Ni Tan, David Simmons, Catalina Carrasco-Pozo, Karin Borges
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase (PCC) pathway. It has been shown to be neuroprotective and anticonvulsant in several models of neurological disorders. Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice. Ten days of triheptanoin pre-treatment did not protect against SE, but it preserved hippocampal mitochondrial functions including state 2, state 3 ADP, state 3 uncoupled respiration, respiration linked to ATP synthesis along with the activities of pyruvate dehydrogenase complex and oxoglutarate dehydrogenase complex 24 h post-SE...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29222803/synthesis-of-biocompatible-titanate-nanofibers-for-effective-delivery-of-neuroprotective-agents
#6
Asya Ozkizilcik, Roger Williams, Z Ryan Tian, Dafin F Muresanu, Aruna Sharma, Hari S Sharma
Nanoscience provides us with new opportunities to develop nanotechnologies for treating, in particular, central nervous system disorders such as Alzheimer disease and multiple sclerosis. From a methodological point of view, it is challenging to deliver drugs effectively across the blood-brain barrier and blood-cerebrospinal fluid barrier. Our 10-year data and reports from both in vivo and in vitro studies, however, have consistently proved that therapeutic drugs of different types can be generally loaded in/on the nanocarriers for targeted and programmable deliveries to the central nervous system with a high degree of efficacy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222786/nerve-growth-factor-induced-angiogenesis-1-endothelial-cell-tube-formation-assay
#7
Philip Lazarovici, Adi Lahiani, Galit Gincberg, Dikla Haham, Arnon Fluksman, Ofra Benny, Cezary Marcinkiewicz, Peter I Lelkes
Nerve growth factor (NGF) is a neurotrophin promoting survival, proliferation, differentiation, and neuroprotection in the embryonal and adult nervous system. NGF also induces angiogenic effects in the cardiovascular system, which may be beneficial in engineering new blood vessels and for developing novel anti-angiogenesis therapies for cancer. Angiogenesis is a cellular process characterized by a number of events, including endothelial cell migration, invasion, and assembly into capillaries. In vitro endothelial tube formation assays are performed using primary human umbilical vein endothelial cells, human aortic endothelial cells, and other human or rodent primary endothelial cells isolated from the vasculature of both tumors and normal tissues...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222776/culture-of-rat-mesencephalic-dopaminergic-neurons-and-application-to-neurotoxic-and-neuroprotective-agents
#8
Stephen D Skaper, Massimo Barbierato, Vanni Ferrari, Morena Zusso, Laura Facci
Dopaminergic neuronal cell degeneration is the principal characteristic feature of the neuropathology of Parkinson disease. Cultures of mesencephalic neurons are widely used as a source of dopaminergic neurons for the study of mechanisms implicated in dopaminergic cell death and for the evaluation of potential dopaminergic neuroprotective agents, including neurotrophic factors. This chapter presents a detailed protocol for the preparation of rat mesencephalic cell cultures and their application to evaluating the effect of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium and the neuroprotective action of brain-derived neurotrophic factor...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222770/ocular-nerve-growth-factor-ngf-and-ngf-eye-drop-application-as-paradigms-to-investigate-ngf-neuroprotective-and-reparative-actions
#9
Paola Tirassa, Pamela Rosso, Angela Iannitelli
The eye is a central nervous system structure that is uniquely accessible to local treatment. Through the ocular surface, it is possible to access the retina, optic nerve, and brain. Animal models of retina degeneration or optic nerve crush could thus serve as tools to investigate whether and how factors, which are anterogradely or retrogradely transported through the optic nerve, might contribute to activate neuroprotection and eventually regeneration. Among these factors, nerve growth factor (NGF) plays a crucial role during development of the visual system, as well as during the entire life span, and in pathological conditions...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222622/toll-like-receptor-4-knockdown-attenuates-brain-damage-and-neuroinflammation-after-traumatic-brain-injury-via-inhibiting-neuronal-autophagy-and-astrocyte-activation
#10
Hongsheng Jiang, Yanzhou Wang, Xin Liang, Xiaofeng Xing, Xiuzhen Xu, Caifeng Zhou
Toll-like receptor 4 (TLR4) has been linked to various pathophysiological conditions, such as traumatic brain injury (TBI). It is reported that posttraumatic neuroinflammation is an essential event in the progression of brain injury after TBI. Recent evidences indicate that TLR4 mediates glial phagocytic activity and inflammatory cytokines production. Thus, TLR4 may be an important therapeutic target for neuroinflammatory injury post-TBI. This study was designed to explore potential effects and underlying mechanisms of TLR4 in rats suffered from TBI...
December 8, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29222553/ghrelin-attenuates-retinal-neuronal-autophagy-and-apoptosis-in-an-experimental-rat-glaucoma-model
#11
Ke Zhu, Meng-Lu Zhang, Shu-Ting Liu, Xue-Yan Li, Shu-Min Zhong, Fang Li, Ge-Zhi Xu, Zhongfeng Wang, Yanying Miao
Purpose: Ghrelin, a natural ligand for the growth hormone secretagogue receptor type 1a (GHSR-1a), may protect retinal neurons against glaucomatous injury. We therefore characterized the underlying mechanism of the ghrelin/GHSR-1a-mediated neuroprotection with a rat chronic intraocular hypertension (COH) model. Methods: The rat COH model was produced by blocking episcleral veins. A combination of immunohistochemistry, Western blot, TUNEL assay, and retrograde labeling of retinal ganglion cells (RGCs) was used...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29222020/synthesis-of-protocatechuic-acid-grafted-chitosan-copolymer-structure-characterization-and-in-vitro-neuroprotective-potential
#12
Chao Xu, Shui Guan, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Xuehu Ma, Tianqing Liu
Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to develop a PCA grafted chitosan (PCA-g-CS) antioxidant copolymer via the method of free radical-induced grafting reaction. The formation of covalent bonds between PCA and CS were confirmed by FTIR, 1H NMR, XRD and UV-Vis...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221948/cnb-001-a-synthetic-pyrazole-derivative-of-curcumin-suppresses-lipopolysaccharide-induced-nitric-oxide-production-through-the-inhibition-of-nf-%C3%AE%C2%BAb-and-p38-mapk-pathways-in-microglia
#13
Tatsuhiro Akaishi, Kazuho Abe
CNB-001, a pyrazole derivative of curcumin, has been found to exert neuroprotective and memory-enhancing effects that may be effective for the treatment of Alzheimer's disease. Since aberrant activation of microglia is involved in the pathogenesis of Alzheimer's disease, the present study was undertaken to investigate the effect of CNB-001 on microglia-mediated inflammatory responses. In primary cultured rat microglia, CNB-001 (1-10µM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), and the potency of CNB-001 was stronger than curcumin...
December 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29221639/nerve-growth-factor-released-from-collagen-scaffolds-protects-axotomized-cholinergic-neurons-of-the-basal-nucleus-of-meynert-in-organotypic-brain-slices
#14
Bettina M Foidl, Buket Ucar, Alina Schwarz, Ana L Rebelo, Abhay Pandit, Christian Humpel
BACKGROUND: Alzheimeŕs disease is accompanied by cell death of cholinergic neurons, resulting in cognitive impairment and memory loss. Nerve growth factor (NGF) is the most potent protein to support survival of cholinergic neurons. New METHOD: Organotypic brain slices of the basal nucleus of Meynert (nBM) are a valuable tool to study cell death of axotomized cholinergic neurons, as well as protective effects of NGF added into the medium. The aim of the present study is to use collagen scaffolds crosslinked with polyethylineglycole and load with NGF to target delivery of NGF to organotypic nBM brain slices...
December 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29220863/a-small-dose-of-apomorphine-counteracts-the-deleterious-effects-of-middle-cerebral-artery-occlusion-in-different-models
#15
F Mastroiacovo, A Gaglione, C L Busceti, L Ryskalin, G Bozza, F Nicoletti, F Orzi, F Fornai
The present manuscript investigates in two animal species by using two different experimental models of middle cerebral artery occlusion (permanent and transient), the neuroprotective effects of the dopamine receptor agonist apomorphine. These effects were evaluated by measuring the infarct volume and by counting muscle strength at different time points following the ischemic insult. Apomorphine at the dose of 3 mg/Kg when adminsitered at two hours following the occlusion of the middle cerebral artery was able to reduce significantly the infarct volume in the cortex of mice and the ischemic volume of the basal ganglia perfused by the perforant branches of the middle cerebral artery in the rat...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29219210/bioenergetic-regulation-of-microglia
#16
REVIEW
Soumitra Ghosh, Erika Castillo, Elma S Frias, Raymond A Swanson
Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability vary under normal and disease states, but how these variations influence microglial function is relatively unknown. Microglia, like most other cell types, express the full complement of gene products required for both glycolytic and oxidative metabolism. Evidence suggests that microglia increase aerobic glycolysis and decrease respiration when activated by various stimuli...
December 8, 2017: Glia
https://www.readbyqxmd.com/read/29219206/neuroprotective-effects-of-antioxidants-in-the-management-of-neurodegenerative-disorders-a-literature-review
#17
Yunes Panahi, Seyyed Mahdi Rajaee, Thomas P Johnston, Amirhossein Sahebkar
It is proven that oxidative stress has a pivotal role in the process of neurodegeneration. The use of antioxidants is an attractive method to prevent the incidence of neurodegenerative diseases. We searched major databases (PubMed, Med Line and Google Scholar) using the keywords of neurodegeneration, oxidative stress, and antioxidant for both review and original studies which have reported the various beneficial effects of antioxidants. About 70 studies were identified for this review. Among various antioxidants, 9 antioxidants with the most applications in research investigations were selected and the major findings concerning their protective effects were reviewed...
December 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29217997/neurochemical-and-behavior-deficits-in-rats-with-iron-and-rotenone-co-treatment-role-of-redox-imbalance-and-neuroprotection-by-biochanin-a
#18
Lijia Yu, Xijin Wang, Hanqing Chen, Zhiqiang Yan, Meihua Wang, Yunhong Li
Increasing evidences show that the etiology of Parkinson's disease (PD) is multifactorial. Studying the combined effect of several factors is becoming a hot topic in PD research. On one hand, iron is one of the essential trace metals for human body; on the other hand, iron may be involved in the etiopathogenesis of PD. In our present study, the rats with increased neonatal iron (120 μg/g bodyweight) supplementation were treated with rotenone (0.5 mg/kg) when they were aged to 14 weeks. We observed that iron and rotenone co-treatment induced significant behavior deficits (time-dependent) and striatal dopamine depletion in the male and female rats, while they did not do so when they were used alone...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29217457/focusing-on-claudin-5-a-promising-candidate-in-the-regulation-of-bbb-to-treat-ischemic-stroke
#19
REVIEW
Jianjun Lv, Wei Hu, Zhi Yang, Tian Li, Shuai Jiang, Zhiqiang Ma, Fulin Chen, Yang Yang
Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates the integrity and permeability of the BBB. Increased claudin-5 expression plays a neuroprotective role in neurological diseases, particularly in cerebral ischemic stroke. Moreover, claudin-5 might be a potential marker for early hemorrhagic transformation detection in ischemic stroke. In light of the distinctive effects of claudin-5 on the nervous system, we present the elaborate network of roles that claudin-5 plays in ischemic stroke...
December 4, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29217406/lncrna-snhg1-promotes-%C3%AE-synuclein-aggregation-and-toxicity-by-targeting-mir-15b-5p-to-activate-siah1-in-human-neuroblastoma-sh-sy5y-cells
#20
Yuan Chen, Ya-Jun Lian, Yun-Qing Ma, Chuan-Jie Wu, Ya-Ke Zheng, Nan-Chang Xie
Numerous long non-coding RNAs (lncRNAs) have been identified as aberrantly expressed in Parkinson's disease (PD). However, limited knowledge is available concerning the roles of dysregulated lncRNAs and the underlying molecular regulatory mechanism in the pathological process of PD. In this study, we found that lncRNA small nucleolar RNA host gene 1 (SNHG1) and seven in absentia homolog 1 (SIAH1) were upregulated, but microRNA-15b-5p (miR-15b-5p) was downregulated in SH-SY5Y cells pretreated with MPP+, as well as in MPTP-induced mouse model of PD...
December 4, 2017: Neurotoxicology
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