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https://www.readbyqxmd.com/read/29917276/curcumin-in-epilepsy-disorders
#1
REVIEW
Ashish Dhir
Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29917258/curcumin-ameliorates-cisplatin-induced-cystopathy-via-activating-nrf2-pathway
#2
Yun Peng Shao, Qiao Zhou, Yun Peng Li, Si Cong Zhang, He Wei Xu, Shuo Wu, Bai Xin Shen, Liu Cheng Ding, Jun Xue, Zheng Sen Chen, Zhong Qing Wei
OBJECTIVES: The present work evaluated preventive effect of curcumin on cisplatin-induced bladder cystopathy. METHODS: Fifteen female rats were divided into (i) Control group administered with physiological saline solution for 5 days; (ii) Cis-P group injected with cisplatin (6 mg/kg); and (iii) Cis-Cur group given cisplatin (6 mg/kg) with curcumin for 5 consecutive days. The function of bladder was measured by means of urodynamic analysis. Furthermore, hematoxylin-eosin staining and Masson trichrome staining were performed for morphological analysis...
June 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29916549/the-nrf2%C3%A2-pgc%C3%A2-1%C3%AE-pathway-activates-kynurenine-aminotransferase-4-via-attenuation-of-an-e3-ubiquitin-ligase-synoviolin-in-a-cecal-ligation-perforation%C3%A2-induced-septic-mouse-model
#3
Yusuke Ishida, Hidetoshi Fujita, Satoko Aratani, Miyuki Chijiiwa, Noboru Taniguchi, Maho Yokota, Yukihiko Ogihara, Naomi Uoshima, Fumiaki Nagashima, Hiroyuki Uchino, Toshihiro Nakajima
Sepsis‑associated encephalopathy (SAE) is a systemic inflammatory response syndrome of which the precise associated mechanisms remain unclear. Synoviolin (Syvn1) is an E3 ubiquitin ligase involved in conditions associated with chronic inflammation, including rheumatoid arthritis, obesity, fibrosis and liver cirrhosis. However, the role of Syvn1 in acute inflammation is not clear. The aim of the present study was to investigate the role of Syvn1 in a septic mouse model induced by cecal ligation/perforation (CLP)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#4
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916537/liraglutide-improves-cognitive-impairment-via-the-ampk-and-pi3k-akt-signaling-pathways-in-type-2-diabetic-rats
#5
Ying Yang, Hui Fang, Gang Xu, Yanfeng Zhen, Yazhong Zhang, Jinli Tian, Dandan Zhang, Guyue Zhang, Jing Xu
Liraglutide is a type of glucagon‑like‑peptide 1 receptor agonist, which has been reported as a novel type of antidiabetic agent with numerous benefits, including cardiovascular and neuroprotective effects. To the best of our knowledge, few studies to date have reported the potential mechanism underlying the neuroprotective effects of liraglutide on rats with type 2 diabetes mellitus (T2DM). The present study aimed to investigate the neuroprotective actions of liraglutide in diabetic rats and to determine the mechanisms underlying these effects...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29915164/linalool-ameliorates-memory-loss-and-behavioral-impairment-induced-by-rem-sleep-deprivation-through-the-serotonergic-pathway
#6
Bo Kyung Lee, An Na Jung, Yi-Sook Jung
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia , has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations...
June 19, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29914875/neuroprotective-effects-of-nicotine-on-hippocampal-long-term-potentiation-in-brain-disorders
#7
Karim A Alkadhi
Long-term potentiation (LTP) is commonly considered as the cellular correlate of learning and memory. In learning and memory impairments, LTP is invariably markedly diminished in the hippocampus, the brain region responsible for memory formation. LTP is measured electrophysiologically in various areas of the hippocampus. Two mechanistically distinct phases of LTP have been identified: early-phase LTP (E-LTP; related to short-term memory) and late-phase LTP (L-LTP; related to long-term memory). These two forms can be severely reduced in a variety of conditions and have been shown to be rescued by treatment with nicotine...
June 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29914798/neuregulin-1-regulates-amyloid-precursor-protein-cell-surface-expression-and-non-amyloidogenic-processing
#8
Young-Jung Kim, Ji-Young Yoo, Ok-Soon Kim, Han-Byeol Kim, Junghwa Ryu, Hye-Sun Kim, Jun-Ho Lee, Hong-Il Yoo, Dae-Yong Song, Tai-Kyoung Baik, Ran-Sook Woo
The amyloid precursor protein (APP) is a key molecule in Alzheimer's disease. The prevailing view is that APP is initially transported to the plasma membrane as a full-length protein. Its localization at the cell surface can trigger downstream signaling and APP cleavage. Our previous work has shown that Neuregulin 1 (NRG1) has neuroprotective effects in an Alzheimer's disease model. In the present study, we examine whether NRG1 signaling is involved in APP expression and non-amyloidogenic processing in neuronal cells...
May 29, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29913427/formononetin-inhibits-neuroinflammation-and-increases-estrogen-receptor-beta-er%C3%AE-protein-expression-in-bv2-microglia
#9
Abdelmeniem El-Bakoush, Olumayokun A Olajide
Formononetin is a bioactive non-steroidal polyphenol found in a variety of plants. In this study we evaluated the effects of formononetin on neuroinflammation in LPS-stimulated BV2 microglia. Results showed that formononetin significantly reduced the production of TNF-α, IL-6 and IL-1β, nitrite and PGE2 , as well as protein levels of iNOS and COX-2. Reporter gene assays showed that formononetin produced inhibition of NF-κB luciferase activity in HEK293 cells stimulated with TNF-α. Immunoblotting experiments revealed an inhibition of IKKα phosphorylation, with the resultant attenuation of phosphorylation and degradation of IκBα following LPS stimulation...
June 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29913410/incensole-acetate-prevents-beta-amyloid-induced-neurotoxicity-in-human-olfactory-bulb-neural-stem-cells
#10
Mohammed A El-Magd, Sara F Khalifa, Faisal Abdulrahman A Alzahrani, Abdelnaser A Badawy, Eman S El-Shetry, Lamess M Dawood, Mohammed M Alruwaili, Hedib A Alrawaili, Engi F Risha, Fathy M El-Taweel, Hany E Marei
β-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer's disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a large verity of neural subtypes. However, this neuroprotective effect was not studied on human olfactory bulb neural stem cells (hOBNSCs). Herein, we evaluated this effect and studied the underlying mechanisms. Exposure to Aβ25-35 (5 and 10 μM for 24 h) inhibited proliferation (revealed by downregulation of Nestin and Sox2 gene expression), and induced differentiation (marked by increased expression of the immature neuronal marker Map2 and the astrocyte marker Gfap) of hOBNSCs...
June 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29913163/loss-of-function-mutation-of-serine-racemase-attenuates-retinal-ganglion-cell-loss-in-diabetic-mice
#11
Haiyan Jiang, Jinlin Du, Juan Song, Yanqi Li, Mengjuan Wu, Jing Zhou, Shengzhou Wu
Consistent results suggest the promoting roles of serine racemase (SR)/D-serine in retinal neurodegeneration in diabetic retinopathy (DR). However, the direct evidence connecting SR deficiency with retinal neuroprotection in genetic model of diabetes mellitus has not been reported. In this investigation, we explore the effect of absence of functional SR on the degeneration of retinal ganglion cells (RGCs) with a diabetic murine model, Ins2Akita mice. We established a murine strain with double mutation, termed Ins2Akita -Srr, by mating heterozygous Ins2Akita mice with homozygous Srrochre269 mice...
June 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29912966/adenosine-a1-receptor-a-neuroprotective-target-in-light-induced-retinal-degeneration
#12
Manuel Soliño, Ester María López, Manuel Rey-Funes, César Fabián Loidl, Ignacio M Larrayoz, Alfredo Martínez, Elena Girardi, Juan José López-Costa
Light induced retinal degeneration (LIRD) is a useful model that resembles human retinal degenerative diseases. The modulation of adenosine A1 receptor is neuroprotective in different models of retinal injury. The aim of this work was to evaluate the potential neuroprotective effect of the modulation of A1 receptor in LIRD. The eyes of rats intravitreally injected with N6-cyclopentyladenosine (CPA), an A1 agonist, which were later subjected to continuous illumination (CI) for 24 h, showed retinas with a lower number of apoptotic nuclei and a decrease of Glial Fibrillary Acidic Protein (GFAP) immunoreactive area than controls...
2018: PloS One
https://www.readbyqxmd.com/read/29911915/targeting-glucose-dependent-insulinotropic-polypeptide-receptor-for-neurodegenerative-disorders
#13
Mahip K Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V S Nemmani
Incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide (GLP-1) exert pleiotropic effects on the endocrine pancreas and nervous system. Expression of GIP and GIP receptor (GIPR) in neurons, their roles in neurogenesis, synaptic plasticity, neurotransmission and neuromodulation, uniquely positions GIPR for therapeutic applications in neurodegenerative disorders. GIP analogues acting as GIPR agonists attenuate neurobehavioral and neuropathological sequelae of neurodegenerative disorders in preclinical models, e...
June 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29909247/protective-and-therapeutic-activity-of-honokiol-in-reversing-motor-deficits-and-neuronal-degeneration-in-the-mouse-model-of-parkinson-s-disease
#14
Hwei-Hsien Chen, Pei-Chi Chang, Chinpiao Chen, Ming-Huan Chan
BACKGROUND: Parkinson's disease (PD) is a progressive and profound movement disorder resulting from neurodegeneration in the nigrostriatal dopaminergic system, but current treatment neither cures nor stops PD from advancing. Based on the ability to suppress oxidative stress, excitotoxicity, and neuroinflammation, the potential of honokiol as a novel neuroprotective agent for PD treatment was determined. METHODS: The hemi-parkinsonian model was used to investigate the protective and therapeutic effects of honokiol on motor dysfunctions and dopaminergic neurodegeneration in mice, with a single unilateral striatal injection of 6-hydroxydopamine (6-OHDA)...
January 12, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29908256/the-protective-effect-of-%C3%AE-lipoic-acid-against-bisphenol-a-induced-neurobehavioral-toxicity
#15
Jasim Khan, Shikha Salhotra, Shahzad Ahmad, Shikha Sharma, Sayed Aliul Hasan Abdi, Basu Dev Banerjee, Suhel Parvez, Sarika Gupta, Sheikh Raisuddin
Bisphenol A (BPA), a well-known xenoestrogen, is ubiquitously utilized in manufacturing of polycarbonated plastics. Convincing evidence suggests that BPA induces neurotoxicity and certain behavioral deficits. α-Lipoic acid (ALA) supplementation has shown protective effect against heart and liver diseases, diabetes, and neurological debility associated with aging. We studied the neuromodulatory effect of ALA against neurotoxicity of BPA in vitro in C8-D1A mouse astrocyte cell line and in vivo in C57BL/6J male mice...
June 13, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29907804/administration-of-molecular-hydrogen-during-pregnancy-improves-behavioral-abnormalities-of-offspring-in-a-maternal-immune-activation-model
#16
Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Takafumi Ushida, Akira Iwase, Taku Nagai, Shinya Toyokuni, Akio Suzumura, Fumitaka Kikkawa
The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2 ) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Short-term memory, sociability and social novelty, and sensorimotor gating were evaluated using the Y-maze, three-chamber, and prepulse inhibition (PPI) tests, respectively, at postnatal 3 or 4 weeks...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907758/mechanism-of-neuroprotection-by-trehalose-controversy-surrounding-autophagy-induction
#17
He-Jin Lee, Ye-Seul Yoon, Seung-Jae Lee
Trehalose is a non-reducing disaccharide with two glucose molecules linked through an α, α-1,1-glucosidic bond. Trehalose has received attention for the past few decades for its role in neuroprotection especially in animal models of various neurodegenerative diseases, such as Parkinson and Huntington diseases. The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose protects neurons by inducing autophagy, thereby clearing protein aggregates...
June 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29907438/effects-of-valproate-on-brain-volumes-in-pediatric-bipolar-disorder-a-preliminary-study
#18
Fadwa Cazala, Robert Suchting, Cristian P Zeni, Isabelle E Bauer, Benson Mwangi, Mon-Ju Wu, Ives Cavalcante Passos, Danielle E Spiker, Giovanna B Zunta-Soares, Jair C Soares
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time...
June 6, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29907217/hydrogen-rich-water-attenuates-oxidative-stress-in-rats-with-traumatic-brain-injury-via-nrf2-pathway
#19
Jia Yuan, Difen Wang, Ying Liu, Xianjun Chen, Hailing Zhang, Feng Shen, Xu Liu, Jiangquan Fu
BACKGROUND: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906751/resveratrol-promotes-neuroprotection-and-attenuates-oxidative-and-nitrosative-stress-in-the-small-intestine-in-diabetic-rats
#20
Paulo Emilio Botura Ferreira, Evandro José Beraldi, Stephanie Carvalho Borges, Maria Raquel Marçal Natali, Nilza Cristina Buttow
Damages to the enteric nervous system caused by diabetes mellitus (DM) are frequently attributed to oxidative and nitrosative stress. We aimed to investigate the effect of Resveratrol (RSV) (10 mg/kg) on oxidative and nitrosative stress in the intestinal wall and morphoquantitative aspects of the myenteric plexus of the duodenum, jejunum and ileum in diabetic rats. Twenty-four rats were distributed into four groups (n = 6/group): control (C group), control treated with RSV (CR group), diabetic (D group), and diabetic treated with RSV (DR group) for 120 days...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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