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https://www.readbyqxmd.com/read/28540896/postrenal-transplant-malignancy-incidence-risk-factors-and-prognosis
#1
Nabil Abdelfadil Elserwy, Esam Elden Lotfy, Mohamad Ashraf Fouda, Medhat Ibrahim Mahmoud, Ahmed Farouk Donia, Mohamed Elsayed Mashaly, Mohamed Hamed Abbas, Mohamed Megahed Abuelmagd, Rasha Kamal Abouelenein, Mabrouk Ibrahim Ismail, Mohamed Adel Bakr
The newer and potent immunosuppressive agents have successfully reduced the risk of rejection after kidney transplantation, but the development of cardiovascular diseases, infections, and malignancy is major factors limiting their success. Posttransplantation malignancy is the second most common cause of death in renal transplant recipients after cardiovascular disease; it is expected that mortality due to malignancy may become the most common cause of death within the next two decades. This study is designed to evaluate the incidence, risk factors, and types of malignancies occurring after renal transplantation and their impact on patient and graft survival...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28538874/clinical-and-laboratory-characteristics-staging-and-outcomes-of-individuals-with-aids-associated-kaposi-s-sarcoma-at-an-university-hospital
#2
Catarina Tenório de Lima, Paulo Sérgio Ramos de Araújo, Heberton Medeiros de Teixeira, Josemir Belo Dos Santos, Vera Magalhães da Silveira
Background: Kaposi's sarcoma continues to be the most common human immunodeficiency virus - associated neoplasm with considerable morbidity and mortality. Objective: To describe the clinical and laboratory characteristics, initial staging, and outcomes of aids patients with Kaposi's sarcoma at an university hospital of Recife, Pernambuco. Methods: This is a descriptive study with analytic character, retrospective, of a case series between 2004 and 2014...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28535490/moderate-ocean-warming-mitigates-but-more-extreme-warming-exacerbates-the-impacts-of-zinc-from-engineered-nanoparticles-on%C3%A2-a%C3%A2-marine-larva
#3
Benjamin Mos, Katrina L Kaposi, Andrew L Rose, Brendan Kelaher, Symon A Dworjanyn
There is growing concern about the combined effects of multiple human-induced stressors on biodiversity. In particular, there are substantial knowledge gaps about the combined effects of existing stressors (e.g. pollution) and predicted environmental stress from climate change (e.g. ocean warming). We investigated the impacts of ocean warming and engineered nanoparticles (nano-zinc oxide, nZnO) on larvae of a cosmopolitan tropical sea urchin, Tripneustes gratilla. Larval T. gratilla were exposed to all combinations of three temperatures, 25, 27 and 29 °C (current SST and near-future predicted warming of +2 and + 4 °C) and six concentrations of nZnO (0, 0...
May 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28534512/a-viral-microrna-downregulates-metastasis-suppressor-cd82-and-induces-cell-invasion-and-angiogenesis-by-activating-the-c-met-signaling
#4
W Li, M Hu, C Wang, H Lu, F Chen, J Xu, Y Shang, F Wang, J Qin, Q Yan, B J Krueger, R Renne, S-J Gao, C Lu
Kaposi's sarcoma (KS) as the most common AIDS-associated malignancy is etiologically caused by KS-associated herpesvirus (KSHV). KS is a highly disseminated and vascularized tumor. KSHV encodes 12 pre-microRNAs that yield 25 mature microRNAs (miRNAs), but their roles in KSHV-induced tumor metastasis and angiogenesis remain largely unclear. KSHV-encoded miR-K12-6 (miR-K6) can generate two mature miRNAs, miR-K6-5p and miR-K6-3p. Recently, we have shown that miR-K6-3p induced cell migration and angiogenesis via directly targeting SH3 domain binding glutamate-rich protein (SH3BGR)...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28531260/comparison-of-kaposi-sarcoma-risk-in-hiv-positive-adults-across-five-continents-a-multiregional-multicohort-study
#5
Julia Bohlius
Background: We compared Kaposi sarcoma (KS) risk in adults who initiated antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods: We included cohort data of HIV-positive adults who initiated ART after 1995 within the framework of two large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). Results: We included 208,140 patients from 57 countries...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28530457/-patient-turnover-in-a-multidisciplinary-emergency-department
#6
Csaba Varga, Zsuzsanna Lelovics, Viktor Soós, Tibor Oláh
INTRODUCTION: More than twenty emergency departments were opened across Hungary in the past years. Data deficiency on patient flow, trends and lack of knowledge of indicators could raise numerous logistical and organisational problems. AIM: Collection, analysis and provision of data to facilitate successful operations of emergency medical care services. METHOD: During a three-year period investigated, at the multidisciplinary Emergency Department of "Moritz Kaposi" Teaching Hospital, data on patient flow (n = 106,203), epidemiology, triage and international classification of diseases were analysed...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28524061/immediate-hypersensitivity-reaction-to-pegylated-liposomal-doxorubicin-management-and-outcome-in-four-patients
#7
Saskia Ingen-Housz-Oro, Anne Pham-Ledard, Pauline Brice, Bénédicte Lebrun-Vignes, Ouidad Zehou, Delphine Reitter, Caroline Ram-Wolff, Nicolas Dupin, Martine Bagot, Olivier Chosidow, Marie Beylot-Barry
Hypersensitivity reactions (HSR) to pegylated liposomal doxorubicin (PLD; Caelyx(®)) have been reported, and symptoms usually resolve with drug withdrawal. However, the risk of relapse of severe HSR and prevention remain poorly described. To report the management and outcome in four patients with HSR due to PLD. Patient characteristics, premedication regimen, rate of infusion, time between onset and HSR, clinical manifestations, and management were documented. A first cycle of PLD was received for cutaneous T-cell lymphoma (n = 3) and Kaposi sarcoma (n = 1)...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28522794/casual-or-causal-two-unique-cases-of-hodgkin-s-lymphoma-a-case-report-and-literature-review
#8
Faizan Malik, Naveed Ali, Syed Imran Mustafa Jafri, Christian Fidler
BACKGROUND Immunosuppressive diseases and therapies have long been connected to risk of malignancies, especially lymphoma. With some diseases and drugs, the association is well established but the data is mostly anecdotal because of the rarity of the situation. CASE REPORT We present 2 rare cases. The first patient had psoriasis, was on etanercept, and developed Hodgkin's lymphoma. This case is rare because psoriasis and etanercept do not usually cause lymphoma, and if they do, it is predominantly Epstein-Barr virus-positive non-Hodgkin's lymphoma...
May 19, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28520616/pediatric-cancer-burden-and-treatment-resources-within-the-pediatric-iedea-consortium
#9
Steven A Brown, Salma Abbas, Mary-Ann Davies, Torsak Bunupuradah, Annette H Sohn, Karl-Günter Technau, Lorna Renner, Valériane Leroy, Andrew Edmonds, Marcel Yotebieng, Catherine C McGowan, Stephany N Duda, Lynne Mofenson, Beverly Musick, Kara Wools-Kaloustian
INTRODUCTION: The incidence and treatment of cancer in HIV-infected children from resource-limited settings has not been extensively studied. OBJECTIVES: Develop and implement a cross-sectional survey to evaluate pediatric cancer burden, diagnostic modalities in use, and treatment availability as perceived by HIV clinic staff at regional International Epidemiology Databases to Evaluate AIDS (IeDEA) sites. METHODS: IeDEA regional investigators developed a cross-sectional clinical site survey which included questions on the numbers and types of pediatric cancers observed, modalities used to treat identified cancers and treatment options available at individual sites in the Asia-Pacific, Latin America, Central Africa, East Africa, West Africa, and Southern Africa regions...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28515293/virus-like-vesicles-of-kaposi-s-sarcoma-associated-herpesvirus-activate-lytic-replication-through-triggering-differentiation-signaling
#10
Danyang Gong, Xinghong Dai, Yuchen Xiao, Yushen Du, Travis J Chapa, Jeffrey R Johnson, Xinmin Li, Nevan J Krogan, Hongyu Deng, Ting-Ting Wu, Ren Sun
Virus-like vesicles (VLVs) are membrane enclosed vesicles that resemble native enveloped viruses in organization, but lack viral capsid and genome. During the productive infection of tumor associated gamma-herpesviruses, both virions and VLVs are produced and released into the extracellular space. However, studies of gamma-herpesvirus associated VLVs have been largely restricted by the technical difficulty of separating VLVs from mature virions. Here, we report a strategy of using a Kaposi's sarcoma-associated herpesvirus (KSHV) mutant defective in small capsid protein, unable to produce mature virions, to selectively isolate VLVs...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514666/a-temporal-proteomic-map-of-epstein-barr-virus-lytic-replication-in-b-cells
#11
Ina Ersing, Luis Nobre, Liang Wei Wang, Lior Soday, Yijie Ma, Joao A Paulo, Yohei Narita, Camille W Ashbaugh, Chang Jiang, Nicholas E Grayson, Elliott Kieff, Steven P Gygi, Michael P Weekes, Benjamin E Gewurz
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28507493/comparison-of-the-incidence-of-skin-cancers-in-patients-on-dialysis-and-after-kidney-transplantation
#12
Joanna Sułowicz, Anna Wojas-Pelc, Ewa Ignacak, Katarzyna Krzanowska, Marek Kuźniewski, Władysław Sułowicz
INTRODUCTION: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers. AIM: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening. MATERIAL AND METHODS: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. All the patients underwent dermatological examination...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28506734/mtor-vegf-pdgfr-and-c-kit-signaling-pathway-activation-in-kaposi-sarcoma
#13
Darcy A Kerr, Satya Vara Prasad Busarla, Devon C Gimbel, Aliyah R Sohani, Rosalynn M Nazarian
Kaposi sarcoma (KS) is a locally progressive, intermediate-grade vascular neoplasm with no known cure, high recurrence rates and potential for wide dissemination. Low efficacy and high toxicity limit current therapeutic options for advanced disease. Activation of mammalian target of rapamycin (mTOR), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and c-kit signaling pathways has been implicated in KS pathogenesis and may suggest a role for targeted inhibitors. KS cases were retrospectively retrieved (n=274), most (90%) associated with human immunodeficiency virus (HIV)...
May 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28506687/human-immunodeficiency-virus-hiv-and-epstein-barr-virus-ebv-related-lymphomas-pathology-view-point
#14
REVIEW
Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
The contribution of Epstein Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV) to the development of specific types of malignant lymphomas occurring in the human immunodeficiency virus (HIV) setting has been extensively studied since the beginning of the HIV epidemic 35 years ago. The introduction of highly active antiretroviral therapies (HAART) in 1996 has changed dramatically the incidence of HIV-related malignancies. Nevertheless, malignant lymphomas continue to be the major group of malignances observed in HIV infected individuals, and the most common cause of cancer related-deaths...
April 7, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28502522/human-herpesvirus-8-related-diseases-histopathologic-diagnosis-and-disease-mechanisms
#15
REVIEW
Matthew Auten, Annette S Kim, Kyle T Bradley, Flavia G Rosado
The emergence of HIV/AIDS more than three decades ago led to an increased incidence of diseases caused by HHV8 co-infection, particularly Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Over time, the development of highly effective AIDS therapies has resulted in a decreased incidence of HHV8-associated entities, which are now more commonly found in patients with undiagnosed and/or untreated AIDS. Due to their rarity, some of these diseases may be difficult to recognize without appropriate clinical information...
April 6, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28501344/kaposi-sarcoma-and-lung-transplant-two-case-reports
#16
Leonor Meira, Carla Damas
No abstract text is available yet for this article.
May 10, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28501028/multicentric-castleman-disease-of-hyaline-vascular-variant-presenting-with-unusual-systemic-manifestations-a-case-report
#17
B M D B Basnayake, A W M Wazil, T Kannangara, N V I Ratnatunga, S Hewamana, A M Ameer
BACKGROUND: Castleman disease is a rare lymphoproliferative disorder presenting with localized or disseminated lymphadenopathy and systemic manifestations. It can be categorized in numerous ways, such as unicentric versus multicentric, histopathological variants (hyaline-vascular, plasma cell, and mixed), or subtypes based on causative viral infections (human immunodeficiency virus, human herpesvirus-8, or Kaposi sarcoma herpesvirus). Presentation ranges from asymptomatic to symptoms involving multiple organs...
May 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28493322/three-year-cancer-incidence-in-blantyre-malawi-2008-2010
#18
Steady J D Chasimpha, D Maxwell Parkin, Leo Masamba, Charles P Dzamalala
In this paper, we present incidence rates of different cancers calculated for the population of Blantyre, Malawi for the period 2008-2010, using data from the Malawi Cancer Registry. Active methods were used for case finding, with standard checks for accuracy and validity performed in CanReg 4. During this 3-year period, a total of 3,711 cases were registered comprising 1,643 men (an estimated age-standardized incidence rate (ASR) of 169.8 per 100,000) and 2,068 women (ASR 238.7 per 10(5) ). Kaposi sarcoma (KS) was the most common cancer in men (40...
May 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28492779/prevalence-of-kaposi-s-sarcoma-in-patients-with-aids-and-associated-factors-s%C3%A3-o-paulo-sp-brazil-2003-2010
#19
Mariza Vono Tancredi, Valdir Monteiro Pinto, Mariliza Henrique da Silva, Sidnei Rana Pimentel, Tatiana Santana Bueno da Silva, Sandra Mitie Akamatsu Ito, Jonathan E Golub, Ana Luiza de Castro Conde Toscano
OBJECTIVE: to estimate the prevalence of Kaposi's sarcoma (KS) in patients with AIDS and identify the associated factors to the occurrence of this neoplasm. METHODS: this is a cross-sectional study with notification data from two AIDS reference centers in São Paulo-SP, Brazil, from January, 2003 to March, 2010; probabilistic linkage and multiple logistic regression methods were applied. RESULTS: among 3,557 AIDS cases, 213 (6%) presented KS; 95...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28490592/epstein-barr-virus-rta-mediated-accumulation-of-dna-methylation-interferes-with-ctcf-binding-in-both-host-and-viral-genomes
#20
Yen-Ju Chen, Yu-Lian Chen, Yao Chang, Chung-Chun Wu, Ying-Chieh Ko, Sai Wah Tsao, Jen-Yang Chen, Su-Fang Lin
Rta, an Epstein-Barr virus (EBV) immediate-early protein, reactivates viral lytic replication that is closely associated with tumorigenesis. In previous studies, we demonstrated that in epithelial cells Rta efficiently induced cellular senescence, which is an irreversible G1 arrest likely to provide a favorable environment for productive replications of EBV and Kaposi's sarcoma-associated herpesvirus (KSHV). To restrict progression of the cell cycle, Rta simultaneously upregulates CDK inhibitors and downregulates MYC, CCND1 and JUN, among others...
May 10, 2017: Journal of Virology
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