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https://www.readbyqxmd.com/read/29773792/mxb-is-an-interferon-induced-restriction-factor-of-human-herpesviruses
#1
Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F Greber, Jovan Pavlovic
The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV)...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29771791/a-successful-model-of-expedited-antiretroviral-therapy-for-clinically-stable-patients-living-with-hiv-in-haiti
#2
Colette Guiteau Moise, Vanessa R Rivera, Kelly A Hennessey, Clovy Bellot, Chris Nicholas, Anna P Fang, Rose Irène Verdier, Patrice Severe, Alix Sainvil, Benedict Charles, Derothy Dorval, Juseline St Amour, Jean W Pape, Serena P Koenig
BACKGROUND: Recommendations for universal antiretroviral therapy (ART) have greatly increased the number of HIV-infected patients who qualify for treatment, particularly with early clinical disease. Less intensive models of care are needed for clinically stable patients. SETTING: A Rapid Pathway (RP) model of expedited outpatient care for clinically stable patients was implemented at the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO) Center, Port-au-Prince, Haiti...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29767490/kaposi-s-sarcoma-associated-with-localized-bullous-pemphigoid-two-conflicting-diseases
#3
Lucia Brambilla, Athanasia Tourlaki, Simona Tavecchio
No abstract text is available yet for this article.
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29762709/determinants-of-%C3%AE-herpesvirus-shedding-in-saliva-among-ugandan-children-and-their-mothers
#4
Robert Newton, Nazzarena Labo, Katie Wakeham, Vickie Marshall, Romin Roshan, Angela Nalwoga, Ismail Sebina, Lawrence Muhangi, Emily L Webb, Wendell Miley, Rosemary Rochford, Alison M Elliott, Denise Whitby
Introduction: Epstein Barr Virus (EBV) and Kaposi's sarcoma associated herpesvirus (KSHV) are transmitted via saliva but factors associated with salivary shedding are unknown. Methods: We measured the shedding of both viruses in the saliva of ~500 Ugandan mothers and their six-year old children, testing all participants for EBV and KSHV seropositive individuals for KSHV. Results: EBV and KSHV were shed by 72% and 22% of the mothers, and by 85% and 40% of children, respectively; boys were more likely than girls to shed KSHV (48% versus 30%), but not EBV...
May 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29748909/the-effect-of-storage-temperature-on-the-biological-activity-of-extracellular-vesicles-for-the-complement-system
#5
Sang June Park, Hyungtaek Jeon, Seung-Min Yoo, Myung-Shin Lee
Extracellular vesicles (EVs) are mediators of intercellular communication by transporting cargo containing proteins, lipids, mRNA, and miRNA. There is increasing evidence that EVs have various roles in regulating migration, invasion, stemness, survival, and immune functions. Previously, we have found that EVs from Kaposi's sarcoma-associated herpesvirus (KSHV)-infected human endothelial cells have the potential to activate the complement system. Although many studies have shown that the physical properties of EVs can be changed by their storage condition, there have been few studies for the stability of biological activity of EVs in various storage conditions...
May 10, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29746587/metabolic-reprogramming-of-kaposi-s-sarcoma-associated-herpes-virus-infected-b-cells-in-hypoxia
#6
Rajnish Kumar Singh, Fengchao Lang, Yonggang Pei, Hem Chandra Jha, Erle S Robertson
Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotypes. Besides modulation of large-scale signaling, KSHV infection also reprograms the metabolic activity of infected cells. However, the mechanism and cellular pathways modulated during these changes are poorly understood. We performed comparative RNA sequencing analysis on cells with stabilized hypoxia inducible factor 1 alpha (HIF1α) of KSHV negative or positive background to identify changes in global and metabolic gene expression...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29746555/human-herpes-virus-8-in-hiv-1-infected-individuals-receiving-cancer-chemotherapy-and-stem-cell-transplantation
#7
Louise E Hogan, Emily Hanhauser, Kristen S Hobbs, Christine D Palmer, Yvonne Robles, Stephanie Jost, Anne S LaCasce, Jeremy Abramson, Ayad Hamdan, Francisco M Marty, Daniel R Kuritzkes, Timothy J Henrich
BACKGROUND: Human Herpes Virus 8 (HHV8) can cause Kaposi's Sarcoma (KS) in immunosuppressed individuals. However, little is known about the association between chemotherapy or hematopoietic stem cell transplantation (HSCT), circulating HHV8 DNA levels, and clinical KS in HIV-1-infected individuals with various malignancies. Therefore, we examined the associations between various malignancies, systemic cancer chemotherapy, T cell phenotypes, and circulating HHV8 DNA in 29 HIV-1-infected participants with concomitant KS or other cancer diagnoses...
2018: PloS One
https://www.readbyqxmd.com/read/29744029/treatment-patterns-and-survival-among-older-adults-in-the-united-states-with-advanced-soft-tissue-sarcomas
#8
Rohan C Parikh, Maria Lorenzo, Lisa M Hess, Sean D Candrilli, Steven Nicol, James A Kaye
Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes. Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29743595/transactivation-of-human-endogenous-retrovirus-k-herv-k-by-kshv-promotes-kaposi-s-sarcoma-development
#9
Lu Dai, Luis Del Valle, Wendell Miley, Denise Whitby, Augusto C Ochoa, Erik K Flemington, Zhiqiang Qin
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of several human cancers such as Kaposi's sarcoma (KS), which represents the most common AIDS-associated malignancy that lacks effective treatment options. Despite its clear role in AIDS malignancies, the fact that only a small set of KSHV-infected patients will eventually develop these tumors implies that additional co-factors are required for the development of KSHV-related cancers. In the current study, we demonstrate for the first time that KSHV de novo infection or viral latent proteins are able to transactivate human endogenous retrovirus K (HERV-K) through a variety of cellular signaling pathways and transcriptional factors...
May 10, 2018: Oncogene
https://www.readbyqxmd.com/read/29743366/regulation-of-virus-associated-lymphoma-growth-and-gene-expression-by-bacterial-quorum-sensing-molecules
#10
Jing Qiao, Yueyu Cao, Jovanny Zabaleta, Liang Yang, Lu Dai, Zhiqiang Qin
Kaposi sarcoma-associated herpesvirus (KSHV) can cause several human cancers including primary effusion lymphoma (PEL), which frequently occur in immunocompromised patients. KSHV infected patients often suffer from polymicrobial infections caused by opportunistic bacterial pathogens. Therefore, it is crucial to understand how these co-infected microorganisms or their secreted metabolites may affect KSHV infection and virus-associated malignancies pathogenesis. Quorum sensing (QS), a cell density-based intercellular communication system, employs extracellular diffusible signaling molecules to regulate bacterial virulence mechanisms in a wide range of bacterial pathogens, such as Pseudomonas aeruginosa , which is one of mostly common opportunistic microorganisms found in immunocompromised individuals...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29741631/relationship-between-anaemia-malaria-co-infection-and-kaposi-sarcoma-associated-herpesvirus-kshv-seropositivity-in-a-population-based-study-in-rural-uganda
#11
Angela Nalwoga, Stephen Cose, Stephen Nash, Wendell Miley, Gershim Asiki, Sylvia Kusemererwa, Robert Yarchoan, Nazzarena Labo, Denise Whitby, Robert Newton
We examined anaemia and malaria as risk factors for KSHV seropositivity and antibody levels in a long-standing rural Ugandan cohort, in which KSHV is prevalent. Samples from 4134 children, aged 1-17 years, with a sex ratio of 1:1 and 3149 adults aged 18-103 years, 41% of whom were males, were analysed. Among children, malaria infection was associated with higher KSHV prevalence (61% versus 41% prevalence among malaria infected and uninfected respectively); malaria was not assessed in adults. Additionally, lower haemoglobin level was associated with an increased prevalence of KSHV seropositivity, both in children and in adults...
May 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29740418/inhibition-of-tip60-reduces-lytic-and-latent-gene-expression-of-kaposi-s-sarcoma-associated-herpes-virus-kshv-and-proliferation-of-kshv-infected-tumor-cells
#12
Sydney Simpson, Guillaume Fiches, Maxime J Jean, Michael Dieringer, James McGuinness, Sinu P John, Meir Shamay, Prashant Desai, Jian Zhu, Netty G Santoso
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus responsible for the development of Kaposi's sarcoma, primary effusion lymphoma (PEL), and Multicentric Castleman's disease in immunocompromised individuals. Despite the burden of these diseases there are few treatment options for afflicted individuals, due in part to our limited understanding of virus-host interactions. Tip60, a histone aceytltransferase (HAT) has been previously shown to interact with both the KSHV latency associated nuclear antigen protein (LANA), which is the main factor in maintaining the viral latent state, and ORF36, a viral kinase expressed in the lytic phase...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29739902/repurposing-cytarabine-for-treating-primary-effusion-lymphoma-by-targeting-kaposi-s-sarcoma-associated-herpesvirus-latent-and-lytic-replications
#13
Marion Gruffaz, Shenghua Zhou, Karthik Vasan, Teresa Rushing, Qing Liu Michael, Chu Lu, Jae U Jung, Shou-Jiang Gao
Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically linked to primary effusion lymphoma (PEL), an aggressive and nontreatable malignancy commonly found in AIDS patients. In this study, we performed a high-throughput screening of 3,731 characterized compounds and identified cytarabine, approved by the FDA for treating numerous types of cancer, as a potent inhibitor of KSHV-induced PEL. We showed the high efficacy of cytarabine in the growth inhibition of various PEL cells by inducing cell cycle arrest and apoptosis...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29736315/kshv-co-infection-regulates-hpv16-cervical-cancer-cells-pathogenesis-in-vitro-and-in-vivo
#14
Lu Dai, Jing Qiao, Luis Del Valle, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of cervical, oral and oropharyngeal cancers. Another oncogenic virus, Kaposi sarcoma-associated herpesvirus (KSHV) can cause several human cancers arising in those immunocompromised patients. KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is relatively low. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasia...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29733294/human-herpesvirus-encoded-kinase-induces-b-cell-lymphomas-in-vivo
#15
Penny M Anders, Nathan D Montgomery, Stephanie A Montgomery, Aadra P Bhatt, Dirk P Dittmer, Blossom Damania
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that is the etiological agent of the endothelial cell cancer Kaposi's sarcoma (KS) and 2 B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV ORF36, also known as viral protein kinase (vPK), is a viral serine/threonine kinase. We previously reported that KSHV vPK enhances cell proliferation and mimics cellular S6 kinase to phosphorylate ribosomal protein S6, a protein involved in protein synthesis...
May 7, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29733293/a-viral-protein-kinase-drug-target-for-tumors
#16
Richard F Ambinder
The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies...
May 7, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29729120/autoimmune-bullous-diseases-in-non-hiv-kaposi-s-sarcoma-a-retrospective-study-in-a-large-cohort-of-patients
#17
A Tourlaki, G Genovese, E Guanziroli, B M Scoppio, E Berti, L Brambilla
BACKGROUND: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpes virus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both KS and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29729117/pseudo-kaposi-sarcoma-report-of-a-case-investigated-by-dermoscopy-reflectance-confocal-microscopy-and-optical-coherence-tomography
#18
A Paganelli, S Bassoli, L Roncati, L Bigi, S Ciardo, G Pellacani
First described in 1965 by Mali et al., pseudo-Kaposi sarcoma (PKS), also known as acroangiodermatitis, is a rare disease inscribed in the setting of cutaneous reactive angiomatoses (CRAs). CRA are all characterized by occlusion and/or inflammation of cutaneous vessels, followed by histiocyte recruitment and endotheliocyte and pericyte hyperplasia. As the name suggests, PKS nearly resembles Kaposi sarcoma, but is benign in its nature. PKS typically presents with violaceous papules and plaques, usually located on the inferior limbs...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29727806/neoplasms-associated-deaths-in-hiv-1-infected-and-non-infected-patients-in-bahia-brazil
#19
Marinho Marques, Estela Luz, Mateus Leal, João Vitor Oliveira, Rejane Patrício, Eduardo Martins Netto, Carlos Brites
BACKGROUND: HIV-infected patients are at a higher risk to develop malignancies than general population. Although AIDS-related malignancies are a common feature of late-stage disease, patients under successful antiretroviral therapy also have an increased risk for development of non-AIDS malignancies. OBJECTIVE: To compare the frequency and characteristics of adults HIV-infected patients and general population who died of malignancies in Bahia, Brazil from January 2000 to December 2010...
May 1, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29722363/pediatric-kaposi-sarcoma-in-context-of-the-hiv-epidemic-in-sub-saharan-africa-current-perspectives
#20
REVIEW
Nader Kim El-Mallawany, Casey L McAtee, Liane R Campbell, Peter N Kazembe
The global experience with pediatric Kaposi sarcoma (KS) has evolved immensely since the onset of HIV (human immunodeficiency virus). In this review, current perspectives on childhood KS are discussed in the context of the HIV epidemic in sub-Saharan Africa. Endemic (HIV-unrelated) KS was first described over 50 years ago in central and eastern Africa, regions where human herpesvirus-8, the causative agent of KS, is endemic. With the alarming rise in HIV prevalence over the past few decades, KS has become not only the most common HIV-related malignancy in Africa, but also one of the most common overall childhood cancers throughout the central, eastern, and southern regions of the continent...
2018: Pediatric Health, Medicine and Therapeutics
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