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https://www.readbyqxmd.com/read/29150768/toe-web-intertrigo-in-kaposi-s-sarcoma-patients-a-microbiological-study-in-a-large-cohort-of-patients
#1
G Nazzaro, A Tourlaki, B Scoppio, A Restelli, A Grancini, L Brambilla
Kaposi 's sarcoma (KS) is a rare multifocal angioproliferative disease associated with human herpes virus 8 (HHV-8) infection, characterized by cutaneous nodules or plaques especially on the lower limbs. Some skin modifications, such as chronic lymphedema, plantar hyperkeratosis and interdigital desquamation, may be associated with consequent impairment of the local immunosurveillance and increased risk of some bacterial or mycotic infections. With the objective of evaluating if bacterial or mycotic infections in KS patients are supported by different microorganisms compared to control patients, we performed an observational retrospective study, comparing positive cultural swabs of interdigital intertrigo of KS patients with positive cultural swabs of interdigital intertrigo of patients admitted to our dermatologic unit during the last 10 years...
November 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29142137/the-epstein-barr-virus-episome-maneuvers-between-nuclear-chromatin-compartments-during-reactivation
#2
Stephanie A Moquin, Sean Thomas, Sean Whalen, Alix Warburton, Samantha G Fernandez, Alison A McBride, Katherine S Pollard, J J L Miranda
The human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. We learned that the latent episome of the human Epstein-Barr virus (EBV) preferentially associates with gene-poor chromosomes and avoids gene-rich chromosomes. Kaposi's sarcoma-associated herpesvirus behaves similarly, but human papillomavirus does not. Contacts localize on the EBV side to OriP, the latent origin of replication. This genetic element, and the EBNA1 protein that binds there, are sufficient to reconstitute chromosome association preferences of the entire episome...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29138338/correction-for-gjyshi-et-al-activated-nrf2-interacts-with-kaposi-s-sarcoma-associated-herpesvirus-latency-protein-lana-1-and-host-protein-kap1-to-mediate-global-lytic-gene-repression
#3
Olsi Gjyshi, Arunava Roy, Sujoy Dutta, Mohanan Valiya Veettil, Dipanjan Dutta, Bala Chandran
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29138337/correction-for-gutierrez-et-al-ets-1-is-required-for-the-activation-of-vegfr3-during-latent-kaposi-s-sarcoma-associated-herpesvirus-infection-of-endothelial-cells
#4
Kimberley D Gutierrez, Valerie A Morris, David Wu, Serge Barcy, Michael Lagunoff
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29138329/correction-for-avey-et-al-discovery-of-a-coregulatory-interaction-between-kaposi-s-sarcoma-associated-herpesvirus-orf45-and-the-viral-protein-kinase-orf36
#5
Denis Avey, Sarah Tepper, Benjamin Pifer, Amritpal Bahga, Hunter Williams, Joseph Gillen, Wenwei Li, Sarah Ogden, Fanxiu Zhu
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29136688/-characteristics-of-erg-fli-1-cd34-cd31-and-f%C3%A2-rag-expression-in-hepatic-malignant-vascular-tumors
#6
Z B Wang, X J An, J F Deng, J H Liu, H Y Shi
Objective: To investigate the expression of ERG, Fli-1, CD34, CD31 and factor Ⅷ-related antigen(FⅧRAg) in hepatic malignant vascular tumors. Methods: A retrospective analysis was conducted on 63 cases of primary hepatic malignant vascular tumors and 31 cases of hepatic other malignant spindle cell tumors collected during January 1986 to January 2014. EnVision method was used to detect the expression of ERG, Fli-1, CD34, CD31, FⅧRAg. Results: Sixty-three cases of malignant vascular tumors, including 24 cases of angiosarcoma, 38 cases of epithelioid hemangioendothelioma and 1 case of hepatic Kaposi's sarcoma...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29116591/prevalence-of-kaposi-s-sarcoma-associated-herpesvirus-in-uygur-and-han-populations-from-the-urumqi-and-kashgar-regions-of-xinjiang-china
#7
Jun Zheng, Yang Yang, Meng Cui, Zhan-Jun Shu, Li-Li Han, Zhen-Qiu Liu, Charles Wood, Tiejun Zhang, Yan Zeng
Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China...
October 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29116588/the-regulatory-role-of-protein-phosphorylation-in-human-gammaherpesvirus-associated-cancers
#8
REVIEW
Yuyan Wang, Shuvomoy Banerjee, Ling Ding, Cankun Cai, Fang Wei, Qiliang Cai
Activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. Phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. Moreovers, the reversible modification of phosphorylation and dephosphorylation can result in different features of the target substrate molecules including DNA binding, protein-protein interaction, subcellular location and enzymatic activity, and is often hijacked by viral infection...
October 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29113328/diabetes-and-risk-of-kaposi-s-sarcoma-effects-of-high-glucose-on-reactivation-and-infection-of-kaposi-s-sarcoma-associated-herpesvirus
#9
Pey-Jium Chang, Yao-Hsu Yang, Pau-Chung Chen, Lee-Wen Chen, Shie-Shan Wang, Ying-Ju Shih, Li-Yu Chen, Chi-Jen Chen, Chien-Hui Hung, Chun-Liang Lin
Patients with diabetes are generally prone to pathogen infection and tumor progression. Here, we investigated the potential association between diabetes and Kaposi's sarcoma (KS), a tumor linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). By using Taiwan's National Health Insurance Research Database, we found that diabetes is statistically associated with increased risk of KS in a case-control study. Since a high level of blood sugar is the hallmark of diabetes, we determined whether high glucose promotes both KSHV reactivation and infection, which are crucial for KS pathogenesis...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109479/viral-and-cellular-n-6-methyladenosine-and-n-6-2-o-dimethyladenosine-epitranscriptomes-in-the-kshv-life-cycle
#10
Brandon Tan, Hui Liu, Songyao Zhang, Suzane Ramos da Silva, Lin Zhang, Jia Meng, Xiaodong Cui, Hongfeng Yuan, Océane Sorel, Shao-Wu Zhang, Yufei Huang, Shou-Jiang Gao
N(6)-methyladenosine (m(6)A) and N(6),2'-O-dimethyladenosine (m(6)Am) modifications (m(6)A/m) of messenger RNA mediate diverse cellular functions. Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) has latent and lytic replication phases that are essential for the development of KSHV-associated cancers. To date, the role of m(6)A/m in KSHV replication and tumorigenesis is unclear. Here, we provide mechanistic insights by examining the viral and cellular m(6)A/m epitranscriptomes during KSHV latent and lytic infection...
November 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29104587/notch-and-its-oncogenic-activity-in-human-malignancies
#11
REVIEW
Marlena Brzozowa-Zasada, Adam Piecuch, Marek Michalski, Oliwia Segiet, Józef Kurek, Marzena Harabin-Słowińska, Romuald Wojnicz
Background: Increasing evidence has demonstrated that Notch signaling is deregulated in human hematological malignancies and solid tumors. This signaling has a protumorigenic effect but may also act as a tumor suppressor. How induction of a single pathway gives rise to the opposite effects in different cell types is still unknown. Methods: This review article includes available data from peer-reviewed publications associated with the role of Notch signaling during cancer pathogenesis...
2017: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29101417/-profile-of-kaposi-sarcoma-patients-in-the-competence-network-hiv-aids
#12
R-E Klingenberg, S Esser, N H Brockmeyer, C Michalik, A Skaletz-Rorowski, A Potthoff
BACKGROUND: Kaposi's sarcoma (KS) represents the most common AIDS-defining neoplasm. Only very few studies regarding the course and treatment of human immunodeficiency virus (HIV)-associated KS have been carried out in Germany. OBJECTIVE: In this study the course of HIV-associated KS was observed in patients from the cohort database of the competence network for HIV/AIDS. MATERIAL AND METHODS: Data from HIV-associated KS patients from 9 German core centers from 1987 to 2011 were retrospectively collected...
November 3, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29099933/kaposi-s-sarcoma-associated-herpesvirus-in-a-rural-ugandan-cohort-1992-2008
#13
Robert Newton, Nazzarena Labo, Katie Wakeham, Wendell Miley, Gershim Asiki, W Thomas Johnston, Denise Whitby
Background: The prevalence and titres of antibodies against Kaposi's sarcoma associated herpesvirus (KSHV) in rural Africa are not completely understood, nor are their trends over time in populations in which HIV is also endemic. We examined prevalence, titres, temporal trends and determinants of anti KSHV antibodies in each of three time periods (1990-91, 1999-2000 and 2007-2008) within a long-standing, rural population-based cohort in southwestern Uganda. Methods: For each period, we measured antibodies to the K8...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29099331/the-topological-train-ride-of-a-viral-long-non-coding-rna
#14
Joanna Sztuba-Solinska, Stuart F J Le Grice
As the notion of small molecule targeting of regulatory viral and cellular RNAs gathers momentum, understanding their structure, and variations thereof, in the appropriate biological context will play a critical role. This is especially true of the ∼1100-nt polyadenylated nuclear (PAN) long non-coding (lnc) RNA of Kaposi's sarcoma herpesvirus (KSHV), whose interaction with viral and cellular proteins is central to lytic infection. Nuclear accumulation of PAN RNA is mediated via a unique triple helical structure at its 3' terminus (within the expression and nuclear retention element, or ENE) which protects it from deadenylation-dependent decay...
November 3, 2017: RNA Biology
https://www.readbyqxmd.com/read/29094771/indolent-waxing-and-waning-cutaneous-presentation-of-htlv-1-associated-adult-t-cell-leukemia-lymphoma-in-an-hiv-1-positive-patient
#15
Justin D Richey, Benjamin J Chen, April C Deng
It is well known that patients infected with human immunodeficiency virus type I (HIV-1) are more likely to develop malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma, and anal and cervical carcinomas.
November 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29084250/kshv-inhibits-stress-granule-formation-by-viral-orf57-blocking-pkr-activation
#16
Nishi R Sharma, Vladimir Majerciak, Michael J Kruhlak, Zhi-Ming Zheng
TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host antiviral response by inhibition of SG formation via a viral lytic protein ORF57. By immunofluorescence analysis, we found that B lymphocytes with KSHV lytic infection are refractory to SG induction. KSHV ORF57, an essential post-transcriptional regulator of viral gene expression and the production of new viral progeny, inhibits SG formation induced experimentally by arsenite and poly I:C, but not by heat stress...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29082271/rna-n-6-adenosine-methylation-m-6-a-steers-epitranscriptomic-control-of-herpesvirus-replication
#17
Fengchun Ye
Latency is a hallmark of all herpesviruses, during which the viral genomes are silenced through DNA methylation and suppressive histone modifications. When latent herpesviruses reactivate to undergo productive lytic replication, the suppressive epigenetic marks are replaced with active ones to allow for transcription of viral genes. Interestingly, by using Kaposi's sarcoma-associated herpesvirus (KSHV) as a model, we recently demonstrated that the newly transcribed viral RNAs are also subjected to post-transcriptional N(6)-adenosine methylation (m(6)A)...
2017: Inflammation and Cell Signaling
https://www.readbyqxmd.com/read/29081916/prospective-study-of-human-herpesvirus-8-oral-shedding-viremia-and-serological-status-among-human-immunodeficiency-virus-seropositive-and-seronegative-individuals-in-sao-paulo-brazil
#18
Paulo H Braz-Silva, Tania R Tozetto-Mendoza, Laura M Sumita, Wilton Freire, Michelle Palmieri, Alan M do Canto, Vivian I Avelino-Silva, Marina Gallottini, Philippe Mayaud, Claudio S Pannuti
Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS). Saliva may play an important role in HHV-8 transmission in specific populations. Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia. A prospective study was conducted of HHV-8 salivary excretion among human immunodeficiency virus HIV-seronegative (n = 47) and -seropositive (n = 44) homosexual men and HIV-seropositive women (n = 32) over a 6-month period with monthly HHV-8 serologies (immunofluorescence assays to identify antibodies to latent and lytic HHV-8 viral proteins, and a whole-virus HHV-8 enzyme-linked immunosorbent assay [ELISA]), monthly HHV-8 DNA serum/plasma detection, and daily self-collected oral rinses for HHV-8-DNA detection using real-time polymerase chain reaction...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29079718/correction-for-chakraborty-et-al-c-cbl-mediated-selective-virus-receptor-translocations-into-lipid-rafts-regulate-productive-kaposi-s-sarcoma-associated-herpesvirus-infection-in-endothelial-cells
#19
Sayan Chakraborty, Mohanan ValiyaVeettil, Sathish Sadagopan, Nitika Paudel, Bala Chandran
No abstract text is available yet for this article.
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29077499/human-immunodeficiency-virus-negative-associated-lymphangioma-like-kaposi-s-sarcoma-with-variable-clinical-presentationsa-case-report
#20
Georgios Kotzias, Modupe Agunbiade, Leon Isaac, Morteza Khaladj
Lymphangioma-like Kaposi's sarcoma (LLKS) is a rare histologic variant of KS. Kaposi's sarcoma is also known as human herpesvirus type 8. The clinical presentation of the LLKS lesion is highly unusual and similar to that of classic KS but with multinodular vascular tumors and lymphedema. We present a 63-year-old native Haitian man with multiple slowly progressive exophytic ulcerated lesions covering more than 60% of his left lower extremity with no systemic involvement. Much confusion surrounded the clinical presentation of these wounds, and we postulated several differential diagnoses...
September 2017: Journal of the American Podiatric Medical Association
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