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Invasive Lobular Breast Cancer

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https://www.readbyqxmd.com/read/28097781/an-analysis-of-oncotype-dx-recurrence-scores-and-clinicopathologic-characteristics-in-invasive-lobular-breast-cancer
#1
Jesse L Felts, Junjia Zhu, Bing Han, Stanley J Smith, Cristina I Truica
The Oncotype DX breast cancer assay (Genomic Health, Redwood City, CA) is increasingly being used to guide treatment decisions for patients with early stage, hormone-positive, Her-2-negative breast cancer. The utility of the Oncotype DX in decision making for treatment of invasive lobular carcinoma (ILC) has not been investigated as the results reported by Genomic Health are largely in a population with invasive ductal carcinoma (IDC). The authors hypothesized that the Oncotype DX recurrence score (RS) distribution for ILC is different than that for IDC...
January 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/28096693/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of-the-literature-and-possible-underlying-mechanisms
#2
J Carlos Villa Guzmán, J Espinosa, R Cervera, M Delgado, R Patón, J M Cordero García
Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28095868/pik3ca-mutations-are-common-in-lobular-carcinoma-in-situ-but-are-not-a-biomarker-of-progression
#3
Vandna Shah, Salpie Nowinski, Dina Levi, Irek Shinomiya, Narda Kebaier Ep Chaabouni, Cheryl Gillett, Anita Grigoriadis, Trevor A Graham, Rebecca Roylance, Michael A Simpson, Sarah E Pinder, Elinor J Sawyer
BACKGROUND: Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a risk factor for future breast cancer rather than a true precursor lesion. The aim of this study was to identify genetic changes that could be used as biomarkers of progression of LCIS to invasive disease using cases of pure LCIS and comparing their genetic profiles to LCIS which presented contemporaneously with associated ILC, on the hypothesis that the latter represents LCIS that has already progressed...
January 17, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#4
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28068979/first-report-on-molecular-breast-cancer-subtypes-and-their-clinico-pathological-characteristics-in-eastern-morocco-series-of-2260-cases
#5
Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Meryem Ouarzane, Tijani El Harroudi, Said Afqir, Mohammed Bellaoui
BACKGROUND: Breast cancer is the most frequent malignancy among women in Eastern Morocco. In this paper, we provide the first report on molecular breast cancer subtypes in this region. This is the largest population-based study on breast cancer among Moroccan women. METHODS: We analyzed 2260 breast cancer cases diagnosed at the Hassan II Regional Oncology Center between October 2005 and December 2012. Clinico-pathological and therapeutic features were studied. Molecular subtypes were determined and their associations with the clinico-pathological characteristics of the tumors were examined...
January 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28062979/contemporary-indications-for-diagnostic-open-biopsy-in-women-assessed-for-screen-detected-breast-lesions-a-ten-year-single-institution-series-of-814-consecutive-cases
#6
Gelareh Farshid, P Grantley Gill
PURPOSE: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives. METHODS: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28057031/-18-fdg-pet-ct-for-predicting-the-outcome-in-er-her2-breast-cancer-patients-comparison-of-clinicopathological-parameters-and-pet-image-derived-indices-including-tumor-texture-analysis
#7
David Groheux, Antoine Martineau, Luis Teixeira, Marc Espié, Patricia de Cremoux, Philippe Bertheau, Pascal Merlet, Charles Lemarignier
BACKGROUND: This study investigated the value of some clinicopathological parameters and 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)FDG-PET/CT) indices, including textural features, to predict event-free survival (EFS) in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) locally advanced breast cancer (BC) patients. METHODS: FDG-PET/CT indices and clinicopathological parameters were assessed before neoadjuvant chemotherapy (NAC)...
January 5, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28048315/su-f-t-650-the-comparison-of-robotic-partial-breast-stereotactic-irradiation-using-mlc-vs-iris-cone
#8
C Ding, R Timmerman, S Jiang, A Rahimi
PURPOSE: To evaluate the dosimetric impact on treatment planning for partial breast stereotactic irradiation using Cyberknife with MLC versus Iris Cone. METHODS: Ten patients whom underwent lumpectomy for DCIS or stage I invasive non-lobular epithelial breast cancer were included in this study. All patients were previously treated on the Cyberknife using Iris cone with the prescription dose of 37.5Gy in 5 fractions covering at least 95% of PTV on our phase I SBRT 5 fraction partial breast irradiation trial...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039597/vinorelbine-induced-perforation-of-a-metastatic-gastric-lesion
#9
REVIEW
W J Mullally, C B O'Súilleabháin, C Brady, S O'Reilly
BACKGROUND: Breast carcinoma metastasis to the gastrointestinal tract is rare and more frequently associated with lobular than ductal carcinoma (Borst and Ingold, Surg 114(4):637-641 [1]). The purpose of this article is to present a case based review of a unique gastrointestinal metastasis and literature review. METHODS: A 46 year old lady with metastatic invasive ductal breast cancer was admitted to A&E with sudden onset of epigastric and left shoulder pain. She completed the first cycle of capecitabine/vinorelbine 1 week previously...
December 30, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28032917/well-differentiated-invasive-breast-cancers-with-equivocal-her2-immunohistochemistry-what-is-the-yield-of-routine-reflex-in-situ-hybridization-testing
#10
Gillian Charlotte Bethune, Alexandra Sophie Louise Pettit, Daniel Veldhuijzen van Zanten, Penelope Jane Barnes
AIMS: The 2013 ASCO/CAP HER2 guidelines recommend testing all invasive breast cancers for HER2, typically with IHC followed by ISH when IHC is equivocal. As well-differentiated breast cancers are rarely HER2 positive, we assessed the value of routine reflex HER2 ISH testing for this subset of breast cancers. METHODS AND RESULTS: We collected HER2 IHC 2+ cases and FISH data from primary breast cancers with well-differentiated tumor types (grade 1 ductal carcinomas, classic lobular carcinomas, tubular, cribriform and pure mucinous carcinomas) at our centre from 2010-2015...
December 29, 2016: Histopathology
https://www.readbyqxmd.com/read/28026205/preoperative-breast-mri-surgeons-patient-selection-patterns-and-potential-bias-in-outcomes-analyses
#11
Jiyon Lee, Elaine Tanaka, Peter R Eby, Shouhao Zhou, Wei Wei, Christine Eppelheimer, Vilert A Loving
OBJECTIVE: The purpose of this study is to determine which patient- and tumor-related and clinical variables influence dedicated breast surgeons' and general surgeons' referrals for preoperative breast MRI for patients with newly diagnosed breast cancer. MATERIALS AND METHODS: Surgeons who perform breast surgery responded to a survey from June 16, 2014, through August 11, 2014. Participants self-identified as breast or general surgeons and provided professional practice details...
December 27, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28024847/dark-field-imaging-recent-developments-and-potential-clinical-applications
#12
Masami Ando, Naoki Sunaguchi, Daisuke Shimao, Adam Pan, Tetsuya Yuasa, Kensaku Mori, Yoshifumi Suzuki, Ge Jin, Jong-Ki Kim, Jae-Hong Lim, Seung-Jun Seo, Shu Ichihara, Norihiko Ohura, Rajiv Gupta
This paper describes an X-ray phase contrast imaging technique using analyzer-based optics called X-ray Dark-Field Imaging that has been under development for the past 10years. We describe the theory behind XDFI, the X-ray optics required for implementing it in practice, and algorithms used for 2D, 2.5D, and 3D image reconstruction. The XDFI optical chain consists of an asymmetrically cut, Bragg-type monochromator-collimator that provides a planar monochromatic X-ray beam, a positioning stage for the specimens, a Laue-case angle analyzer, and one or two cameras to capture the dark and bright field images...
December 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28002557/reoperation-rates-in-ductal-carcinoma-in-situ-vs-invasive-breast-cancer-after-wire-guided-breast-conserving-surgery
#13
Linnea Langhans, Maj-Britt Jensen, Maj-Lis M Talman, Ilse Vejborg, Niels Kroman, Tove F Tvedskov
Importance: New techniques for preoperative localization of nonpalpable breast lesions may decrease the reoperation rate in breast-conserving surgery (BCS) compared with rates after surgery with the standard wire-guided localization. However, a valid reoperation rate for this procedure needs to be established for comparison, as previous studies on this procedure include a variety of malignant and benign breast lesions. Objectives: To determine the reoperation rate after wire-guided BCS in patients with histologically verified nonpalpable invasive breast cancer (IBC) or ductal carcinoma in situ (DCIS) and to examine whether the risk of reoperation is associated with DCIS or histologic type of the IBC...
December 21, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27995453/laparoscopic-glissonean-pedicle-transection-takasaki-for-negative-fluorescent-counterstaining-of-segment-6
#14
Takashi Mizuno, Rahul Sheth, Masakazu Yamamoto, Hyun Seon C Kang, Suguru Yamashita, Thomas A Aloia, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, C Conrad
BACKGROUND: The portal pedicles are wrapped in connective tissue known as the Walaeus sheath, which abut Laennec's capsule covering the liver parenchyma. Precise knowledge of this anatomic relationship allows for dissection of this interspace and early control of the segmental portal pedicle (Glissonean pedicle transection method [GPTM], Takasaki approach). (1,2) Subsequent systemic administration of indocyanine green (ICG) leads to negative counterstaining of the segment to be resected...
December 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27994939/pointwise-mutual-information-quantifies-intratumor-heterogeneity-in-tissue-sections-labeled-with-multiple-fluorescent-biomarkers
#15
Daniel M Spagnolo, Rekha Gyanchandani, Yousef Al-Kofahi, Andrew M Stern, Timothy R Lezon, Albert Gough, Dan E Meyer, Fiona Ginty, Brion Sarachan, Jeffrey Fine, Adrian V Lee, D Lansing Taylor, S Chakra Chennubhotla
BACKGROUND: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity. METHODS: We demonstrate how to quantify spatial heterogeneity from immunofluorescence pathology samples, using a set of 3 basic breast cancer biomarkers as a test case...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27988977/prognostic-factors-for-metachronous-contralateral-breast-cancer-implications-for-management-of-the-contralateral-breast
#16
Schelomo Marmor, Pamela R Portschy, Erin E Burke, Beth A Virnig, Todd M Tuttle
The absolute number of breast cancer survivors who are at risk for metachronous contralateral breast cancer (mCBC) has dramatically increased. The objectives of this study were to identify factors predictive of survival for patients with mCBC and to determine clinicopathological factors predictive of advanced mCBC. Using the Surveillance, Epidemiology, and End Results data base, we identified women, ages 18-80, diagnosed with invasive breast cancer from 1992 to 2010. We excluded patients with bilateral and stage IV primary breast cancer...
December 18, 2016: Breast Journal
https://www.readbyqxmd.com/read/27986508/screening-breast-mri-outcomes-in-routine-clinical-practice-comparison-to-bi-rads-benchmarks
#17
Roberta M Strigel, Jennifer Rollenhagen, Elizabeth S Burnside, Mai Elezaby, Amy M Fowler, Frederick Kelcz, Lonie Salkowski, Wendy B DeMartini
RATIONALE AND OBJECTIVES: The BI-RADS Atlas 5th Edition includes screening breast magnetic resonance imaging (MRI) outcome benchmarks. However, the metrics are from expert practices and clinical trials of women with hereditary breast cancer predispositions, and it is unknown if they are appropriate for routine practice. We evaluated screening breast MRI audit outcomes in routine practice across a spectrum of elevated risk patients. MATERIALS AND METHODS: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included all consecutive screening breast MRI examinations from July 1, 2010 to June 30, 2013...
December 13, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27925203/the-genetic-landscape-of-breast-carcinomas-with-neuroendocrine-differentiation
#18
Caterina Marchiò, Felipe C Geyer, Charlotte Ky Ng, Salvatore Piscuoglio, Maria R De Filippo, Marco Cupo, Anne M Schultheis, Raymond S Lim, Kathleen A Burke, Elena Guerini-Rocco, Mauro Papotti, Larry Norton, Anna Sapino, Britta Weigelt, Jorge S Reis-Filho
Neuroendocrine breast carcinomas (NBCs) account for 2-5% of all invasive breast cancers, and are histologically similar to neuroendocrine tumours from other sites. They typically express oestrogen receptor (ER), and are HER2-negative and of luminal 'intrinsic' subtype. Here, we sought to define the mutational profile of NBCs, and to investigate whether NBCs and common forms of luminal (ER(+) /HER2(-) ) breast carcinoma show distinct repertoires of somatic mutations. Eighteen ER(+) /HER2(-) NBCs, defined as harbouring >50% of tumour cells expressing chromogranin A and/or synaptophysin, and matched normal tissues were microdissected and subjected to massively parallel sequencing targeting all exons of 254 genes most frequently mutated in breast carcinomas and/or related to DNA repair...
December 7, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27856630/a-prospective-clinical-trial-of-18f-fluciclovine-pet-ct-neoadjuvant-therapy-response-in-invasive-ductal-and-invasive-lobular-breast-cancers
#19
Gary A Ulaner, Debra Goldman, Adriana Corben, Serge Lyashchenko, Mithat Gonen, Jason Lewis, Maura Dickler
: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid ((18)F-Fluciclovine) is a leucine analog radiotracer that depicts amino acid transport into cells. (18)F-Fluciclovine PET/CT visualizes malignancy including prostate cancer, invasive ductal breast cancer (IDC) and invasive lobular breast cancers (ILC). It has not been shown whether changes in (18)F-Fluciclovine avidity reflect changes in tumor burden resulting from treatment. This prospective clinical trial evaluates changes in (18)F-Fluciclovine-avidity compared to breast cancer therapy response, as determined by residual tumor burden on pathology...
November 17, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27846863/prognostic-significance-of-mucin-expression-profiles-in-breast-carcinoma-with-signet-ring-cells-a-clinicopathological-study
#20
Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei, Zenya Naito
BACKGROUND: Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance of SRCs undetermined. We have described clinicopathological characteristics of patients with breast cancer containing SRCs in relation to the expression levels of MUC1, MUC2, MUC4, MUC5AC, and MUC6. METHODS: Twenty-two breast cancer cases with variable degrees of SRC population were retrospectively studied...
November 15, 2016: Diagnostic Pathology
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