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Invasive Lobular Breast Cancer

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https://www.readbyqxmd.com/read/29323551/gamma-imaging-guided-minimally-invasive-breast-biopsy-initial-clinical-experience
#1
Rachel F Brem, Anita K Mehta, Jocelyn A Rapelyea, Esma A Akin, Adriana M Bazoberry, Christel D Velasco
OBJECTIVE: The purpose of this study was to evaluate our initial experience with gamma imaging-guided vacuum-assisted breast biopsy in women with abnormal findings. MATERIALS AND METHODS: A retrospective review of patients undergoing breast-specific gamma imaging (BSGI), also known as molecular breast imaging (MBI), between April 2011 and October 2015 found 117 nonpalpable mammographically and sonographically occult lesions for which gamma imaging-guided biopsies were recommended...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#2
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29310602/clinical-and-pathological-factors-influencing-survival-in-a-large-cohort-of-triple-negative-breast-cancer-patients
#3
Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D'Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù
BACKGROUND: To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available. METHODS: Pathological characteristics and clinical records of 841 TNBCs diagnosed between 1994 and 2015 in four major oncologic centers from Sardinia, Italy, were reviewed. Multivariate hazard ratios (HRs) for mortality and recurrence according to various clinicopathological factors were estimated using Cox proportional hazards models...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29306176/incidence-and-tumour-characteristics-of-bilateral-and-unilateral-interval-breast-cancers-at-screening-mammography
#4
Rob M G van Bommel, Adri C Voogd, Joost Nederend, Wikke Setz-Pels, Marieke W J Louwman, Luc J Strobbe, Dick Venderink, Vivianne C G Tjan-Heijnen, Lucien E M Duijm
BACKGROUND: Detected by screening mammography, bilateral breast cancer has a different pathological profile compared to unilateral breast cancer. We investigated the incidence of bilateral interval breast cancers and compared their characteristics with those of unilateral interval breast cancers. METHODS: We included all 468,720 screening mammograms of women who underwent biennial screening mammography in the South of the Netherlands between January 2005 and January 2015...
January 3, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29299726/observation-versus-excision-of-lobular-neoplasia-on-core-needle-biopsy-of-the-breast
#5
Hank Schmidt, Brittany Arditi, Margaux Wooster, Christina Weltz, Laurie Margolies, Ira Bleiweiss, Elisa Port, Shabnam Jaffer
PURPOSE: Controversy surrounds management of lobular neoplasia (LN), [atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS)], diagnosed on core needle biopsy (CNB). Retrospective series of pure ALH and LCIS reported "upgrade" rate to DCIS or invasive cancer in 0-40%. Few reports document radiologic/pathologic correlation to exclude cases of discordance that are the likely source of most upgrades, and there is minimal data on outcomes with follow-up imaging and clinical surveillance...
January 3, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29286226/almost-complete-lack-of-human-cytomegalovirus-and-human-papillomaviruses-genome-in-benign-and-malignant-breast-lesions-in-shiraz-southwest-of-iran
#6
Sahar Bakhtiyrizadeh, Seyed Younes Hosseini, Ramin Yaghobi, Aliakbar Safaei, Jamal Sarvari
Breast cancer ranks as the most common cancer among women worldwide. There have been controversial reports regarding contributions of human papillomaviruses (HPVs) and human cytomegalovirus (HCMV) to its development. The aim of this study was to determine the frequency of HPV and HCMV positivity in benign and malignant breast tumors. Materials and Methods: Formalin fixed paraffin-embedded tissue specimens of 150 breast cancers (invasive ductal and lobular carcinomas) and 150 non-malignant breast lesions (fibroadenomas, fibrocystic disease and adenosis) were examined...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29281999/invasive-micropapillary-carcinoma-of-the-breast-overexpresses-muc4-and-is-associated-with-poor-outcome-to-adjuvant-trastuzumab-in-her2-positive-breast-cancer
#7
María F Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A Rivas, Rosalía Cordo-Russo, Cecilia J Proietti, Elmer A Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G Gercovich, Eduardo Cortese, Matías Amasino, Pablo Guzmán, Juan C Roa, Patricia V Elizalde, Roxana Schillaci
BACKGROUND: Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29274617/outcomes-in-women-with-invasive-ductal-or-invasive-lobular-early-stage-breast-cancer-treated-with-anastrozole-or-exemestane-in-cctg-ncic-ctg-ma-27
#8
K Strasser-Weippl, G Sudan, R Ramjeesingh, L E Shepherd, J O'Shaughnessy, W R Parulekar, P E R Liedke, B E Chen, P E Goss
BACKGROUND: Histological subtype, (invasive ductal breast cancer (IDBC)/invasive lobular breast cancer (ILBC)), might be a marker for differential response to endocrine therapy in breast cancer. METHODS: Clinical trial MA.27 compared 5 years of adjuvant anastrozole or exemestane in postmenopausal patients with hormone receptor positive early breast cancer. We evaluated IDBC versus ILBC (based on original pathology reports) as predictor for event-free survival (EFS) and overall survival (OS)...
December 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29230662/relationship-of-histologic-grade-and-histologic-subtype-with-oncotype-dx-recurrence-score-retrospective-review-of-863-breast-cancer-oncotype-dx-results
#9
Kamaljeet Singh, Xin He, Elizabeth T Kalife, Shahrzad Ehdaivand, Yihong Wang, C James Sung
PURPOSE: Oncotype Dx (ODx) is a multigene assay that is prognostic and predictive in estrogen receptor (ER) positive early breast cancer. ODx recurrence score (RS) is reported to be histologic grade dependent. Relationship of RS with breast cancer histologic subtypes is unknown. This study was designed to assess the relationship of histologic subtype with RS. Histologic grade dependence of RS was also investigated. METHODS: Results of consecutive ODx tests (1/2007-7/2016) from two institutions were reviewed...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29197477/neoadjuvant-systemic-therapy-in-invasive-lobular-breast-cancer-is-it-indicated
#10
Karen Tsung, Stephen R Grobmyer, Chao Tu, Jame Abraham, G Thomas Budd, Stephanie A Valente
BACKGROUND: This study investigated patients with invasive lobular breast carcinoma (ILC) to determine the benefit of neoadjuvant systemic therapy (NAST). METHODS: Patients with ILC treated from 2006 to 2015 were identified. Tumor characteristics and treatment data were analyzed. RESULTS: Of the 560 patients with ILC, 77 patients received NAST. Patients who received NAST presented with larger clinical T stages compared to patients who received surgery first (p < 0...
November 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29178691/-analysis-of-positive-margins-risk-factors-and-long-term-recurrence-in-the-conservative-treatment-of-breast-cancer
#11
S Barant, J C Noël, P Simon
INTRODUCTION: breast conserving therapy remains the first choice in breast cancer care for the early stages. Adequate surgical margins are essential to reduce the risk of locoregional recurrence. This study aims to identify risk factors of positive margins and locoregional recurrence. MATERIALS AND METHODS: 437 patients who underwent a lumpectomy for invasive breast carcinoma or ductal carcinoma in situ have been included. Age, surgical margins, size, type, grade and number of tumor foci, the presence of ductal carcinoma in situ, lymph node status, expression of hormone receptors and HER-2 gene were assessed as risk factors for positive margins and locoregional recurrence...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29176653/estrogen-induces-c-kit-and-an-aggressive-phenotype-in-a-model-of-invasive-lobular-breast-cancer
#12
J Chuck Harrell, Thomas M Shroka, Britta M Jacobsen
Among the molecular subtypes of breast cancer are luminal (A or B) estrogen receptor positive (ER+), HER2+, and triple negative (basal-like). In addition to the molecular subtypes, there are 18 histologic breast cancer subtypes classified on appearance, including invasive lobular breast carcinoma (ILC), which are 8-15% of all breast cancers and are largely ER+ tumors. We used a new model of ER+ ILC, called BCK4. To determine the estrogen regulated genes in our ILC model, we examined BCK4 xenograft tumors from mice supplemented with or without estrogen using gene expression arrays...
November 27, 2017: Oncogenesis
https://www.readbyqxmd.com/read/29160721/isolated-atypical-lobular-hyperplasia-diagnosed-on-breast-biopsy-low-upgrade-rate-on-subsequent-excision-with-long-term-follow-up
#13
Kristen E Muller, Emily Roberts, Lili Zhao, Julie M Jorns
CONTEXT: - The upgrade rate to carcinoma on excision for atypical lobular hyperplasia diagnosed on breast biopsy is controversial. OBJECTIVE: - To review cases with isolated atypical lobular hyperplasia on biopsy to establish the rate of upgrade on excision and correlate with long-term follow-up. DESIGN: - A database search was performed for 191 months to identify breast core biopsies with isolated atypical lobular hyperplasia. Cases with other atypical lesions in the biopsy or discordant radiologic-pathologic findings were excluded...
November 21, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29132567/lobular-breast-cancer-different-disease-different-algorithms
#14
REVIEW
Anita Mamtani, Tari A King
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer, with a unique pathogenesis and distinct clinical biology. ILCs display a characteristic loss of E-cadherin, are largely estrogen receptor positive, HER2 negative, and low to intermediate grade. These features portend a favorable prognosis, but there is a tendency for late recurrences and atypical metastases. ILCs tend to be insidious and infiltrative, which can pose a challenge for diagnosis, and emerging data suggest they may have a propensity for a differing response to standard therapies...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29131161/rapid-virtual-hematoxylin-and-eosin-histology-of-breast-tissue-specimens-using-a-compact-fluorescence-nonlinear-microscope
#15
Lucas C Cahill, Michael G Giacomelli, Tadayuki Yoshitake, Hilde Vardeh, Beverly E Faulkner-Jones, James L Connolly, Chi-Kuang Sun, James G Fujimoto
Up to 40% of patients undergoing breast conserving surgery for breast cancer require repeat surgeries due to close to or positive margins. The lengthy processing required for evaluating surgical margins by standard paraffin-embedded histology precludes its use during surgery and therefore, technologies for rapid evaluation of surgical pathology could improve the treatment of breast cancer by reducing the number of surgeries required. We demonstrate real-time histological evaluation of breast cancer surgical specimens by staining specimens with acridine orange (AO) and sulforhodamine 101 (SR101) analogously to hematoxylin and eosin (H&E) and then imaging the specimens with fluorescence nonlinear microscopy (NLM) using a compact femtosecond fiber laser...
November 13, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29127760/preoperative-breast-mri-examination-for-all-patients-with-histologically-proven-breast-cancer-a-concept-for-a-prospective-multicenter-trial
#16
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29124544/reproductive-risk-factor-associations-with-lobular-and-ductal-carcinoma-in-the-carolina-breast-cancer-study
#17
Lindsay A Williams, Hazel B Nichols, Katherine A Hoadley, Chiu Kit Tse, Joseph Geradts, Mary Elizabeth Bell, Charles M Perou, Michael I Love, Andrew F Olshan, Melissa A Troester
BACKGROUND: Invasive lobular breast tumors display unique reproductive risk factor profiles. Lobular tumors are predominantly Luminal A subtype, and it is unclear whether reported risk factor associations are independent of molecular subtype. METHODS: Polytomous logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between risk factors and histologic subtype [ductal (n = 2,856), lobular (n = 326), and mixed ductal-lobular (n = 473)] in the Carolina Breast Cancer Study (1993-2013)...
November 9, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29119353/impact-of-microinvasion-on-breast-cancer-mortality-in-women-with-ductal-carcinoma-in-situ
#18
Victoria Sopik, Ping Sun, Steven A Narod
BACKGROUND: Ductal carcinoma in situ (DCIS) is a neoplastic proliferation of epithelial cells which is confined within the basement membrane of the mammary ductal-lobular system. It is of interest to determine to what extent the potential to metastasize increases for DCIS patients when the basement membrane is breached (i.e. microinvasion is present). METHODS: We retrieved the records of 525,395 women who had either first primary DCIS or small (≤ 2.0 cm) node-negative invasive breast cancer in the Surveillance, Epidemiology and End Results (SEER) registries database (1990-2013)...
November 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29105963/does-the-use-of-pretreatment-mri-change-the-management-of-patients-with-newly-diagnosed-breast-cancer
#19
James Hlubocky, Sharukh Bhavnagri, Ann Swinford, Carol Mitri, Murray Rebner, Vidya Pai
Breast MRI plays a critical role in the diagnosis and management of breast cancer. The purpose of this study is to evaluate the effect of preoperative breast MRI on the management of a large cohort of breast cancer patients at our institution. This study is a retrospective chart review of all newly diagnosed breast cancer patients who underwent preoperative breast MRI at our institution between January 1, 2004 and December 31, 2009. 1352 patients comprised the study population. 241 (17.8%) patients underwent a change in surgical management as a result of preoperative MRI...
November 5, 2017: Breast Journal
https://www.readbyqxmd.com/read/29102711/pleomorphic-lobular-carcinoma-in-situ-diagnosed-by-breast-core-biopsy-clinicopathologic-features-and-correlation-with-subsequent-excision
#20
Tianhua Guo, Yihong Wang, Nella Shapiro, Susan Fineberg
INTRODUCTION: Pleomorphic lobular carcinoma in situ (PLCIS) is a variant of LCIS with high-grade morphologic features. The number of case series studying PLCIS is limited, and clinical management of patients with PLCIS is controversial. We report a breast core biopsy (BCBx) series of PLCIS. MATERIALS AND METHODS: We reviewed 37 cases of PLCIS with or without microinvasion diagnosed by BCBx. PLCIS was defined as dyscohesive cells showing acinar expansion and loss of immunohistochemical membranous expression of e-cadherin or beta-catenin with nuclear pleomorphism with at least 2- to 3-fold variation in nuclear size, membrane irregularities, and variably prominent nucleoli...
October 7, 2017: Clinical Breast Cancer
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