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Invasive Lobular Breast Cancer

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https://www.readbyqxmd.com/read/28775079/invasive-lobular-breast-carcinoma-metastasising-to-the-rectum
#1
Nishant Cherian, Nafees Ahmad Qureshi, Callum Cairncross, Mamoon Solkar
Gastrointestinal (GI) metastasis from a primary breast carcinoma is uncommon, with the rectum being one of the least reported sites in the literature. We report a case of a 79-year-old woman who underwent treatment for an infiltrative lobular carcinoma of the right breast with nodal involvement, and 10 years later developed recurrence in the form of rectal metastasis. Spread to the GI tract is most commonly seen with lobular breast carcinomas. Any patient with a history of breast cancer presenting typically or atypically with abdominal symptoms or altered bowel habit should raise a high index of suspicion for recurrent or metastatic disease...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28770103/subclonal-analysis-in-a-lobular-breast-cancer-with-classical-and-solid-growth-pattern-mimicking-a-solid-papillary-carcinoma
#2
Matthias Christgen, Stephan Bartels, Jana Lisa van Luttikhuizen, Maximilian Schieck, Stefanie Pertschy, Sudip Kundu, Ulrich Lehmann, Bjoern Sander, Enrico Pelz, Florian Länger, Brigitte Schlegelberger, Doris Steinemann, Hans Kreipe
Recently, a new variant of invasive lobular breast cancer (ILBC) with solid-papillary-like growth pattern has been described. We present a case of ILBC with solid-papillary-like growth pattern in the main tumour mass and classical invasive lobular growth pattern in adjacent satellite foci. The two tumour components were subjected to comprehensive molecular analyses. Both components were ER/PR-positive, HER2-negative, and showed a complete loss of E-cadherin and beta-catenin protein expression, as determined by immunohistochemistry...
July 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28767397/clinicopathological-characteristics-and-survival-outcomes-of-invasive-lobular-carcinoma-in-different-races
#3
Li-Yuan Yang, Li-Peng Yang, Biao Zhu
To investigate the clinicopathological characteristics and to determine whether there is a differential effect of race and examine survival outcomes according to race, 18,295 breast invasive lobular carcinoma (ILC) patients were identified in the Surveillance, Epidemiology, and End Result (SEER) database, which includes White patients (n=15,936), Black patients (n=1,451) and patients of other races (including American Indians/Alaskan Natives and Asian/Pacific Islanders) (n=908). The Black ILC patients presented a higher rate of advanced histological grades and American Joint Committee on Cancer (AJCC) stages, a higher rate of lymph node (LN) involvement and a lower rate of progesterone receptors (PR)-positivity than the White patients and other races...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28764784/e-cadherin-expression-phenotypes-associated-with-molecular-subtypes-in-invasive-non-lobular-breast-cancer-evidence-from-a-retrospective-study-and-meta-analysis
#4
Jiang-Bo Liu, Chen-Yi Feng, Miao Deng, Dong-Feng Ge, De-Chun Liu, Jian-Qiang Mi, Xiao-Shan Feng
BACKGROUND: This retrospective study and meta-analysis was designed to explore the relationship between E-cadherin (E-cad) expression and the molecular subtypes of invasive non-lobular breast cancer, especially in early-stage invasive ductal carcinoma (IDC). METHODS: A total of 156 post-operative cases of early-stage IDCs were retrospectively collected for the immunohistochemistry (IHC) detection of E-cad expression. The association of E-cad expression with molecular subtypes of early-stage IDCs was analyzed...
August 1, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28757653/distinct-pattern-of-metastases-in-patients-with-invasive-lobular-carcinoma-of-the-breast
#5
Aju Mathew, Padma S Rajagopal, Vipin Villgran, Gurprataap S Sandhu, Rachel C Jankowitz, Mini Jacob, Margaret Rosenzweig, Steffi Oesterreich, Adam Brufsky
BACKGROUND: Invasive lobular carcinoma (ILC) comprises around 10 - 15% of invasive breast cancers. Few prior studies have demonstrated a unique pattern of metastases between ILC and the more common invasive ductal carcinoma (IDC). To our knowledge, such data is limited to first sites of distant recurrence. We aimed to perform a comparison of the metastatic pattern of ILC and IDC at first distant recurrence as well as over the entire course of metastatic disease. METHODS: We used a prospectively collated database of patients with metastatic breast cancer...
June 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28746732/short-term-and-long-term-clinical-outcomes-of-uncommon-types-of-invasive-breast-cancers
#6
Mu Yang, Wei Bao, Xinmin Zhang, Yibin Kang, Bruce Haffty, Lanjing Zhang
BACKGROUND: Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are predominant and well-documented types of invasive breast cancers (IBC). However, clinical outcomes of other types of IBC (i.e., uncommon IBC), which collectively account for about 20% of all IBC cases, are largely unknown. METHODS: We identified all IBC cases diagnosed in 2004-2006 (n=159,293) and 2010-2011 (n=118,822) from the Surveillance, Epidemiology and End Results (SEER) database...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28742702/trends-on-axillary-surgery-in-nondistant-metastatic-breast-cancer-patients-treated-between-2011-and-2015-a-dutch-population-based-study-in-the-acosog-z0011-and-amaros-era
#7
Ingrid G M Poodt, Pauline E R Spronk, Guusje Vugts, Thijs van Dalen, M T F D Vrancken Peeters, Marjolijn L Rots, Anne Kuijer, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
OBJECTIVES: To evaluate patterns of care in axillary surgery for Dutch clinical T1-4N0M0 (cT1-4N0M0) breast cancer patients and to assess the effect of the American College for Surgeons Oncology Group (ACOSOG)-Z0011 and After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) trial on axillary surgery patterns in Dutch cT1-2N0M0 sentinel node positive breast cancer patients. BACKGROUND: Since publication of the ACOSOG-Z0011 and AMAROS trial, omitting a completion axillary lymph node dissection (cALND) in sentinel node positive breast cancer patients is proposed in selected patients...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28739585/the-burdens-and-uncertainties-of-doing-what-one-should-do
#8
EDITORIAL
Victor G Vogel
Despite FDA approval of drugs to reduce the risk of breast cancer in women at increased risk, uptake of these drugs has been poor despite the publication of numerous studies that demonstrate both their effectives and safety. National organizations have made recommendations for their use, but both physicians and their patients do not fully understand either breast cancer risk factors or risk assessment or the indications for using risk-reducing agents. Histologically predisposing conditions, such as ductal or lobular atypia and lobular carcinoma in situ, impart particularly high risks of developing subsequent invasive breast cancer...
July 24, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28731046/pd-l1-expression-and-the-immune-microenvironment-in-primary-invasive-lobular-carcinomas-of-the-breast
#9
Elizabeth D Thompson, Janis M Taube, Rebecca J Asch-Kendrick, Aleksandra Ogurtsova, Haiying Xu, Rajni Sharma, Alan Meeker, Pedram Argani, Leisha A Emens, Ashley Cimino-Mathews
Tumor-infiltrating lymphocytes and immune checkpoint proteins such as PD-L1 are potential prognostic factors and therapeutic targets in breast cancer. Most studies characterizing the breast tumor immune microenvironment have focused on ductal carcinomas. Here we investigate the tumor microenvironment of primary invasive lobular carcinomas. Previously constructed tissue microarrays of 47 lobular carcinomas were labeled by immunohistochemistry for PD-L1, CD8, CD20, and FoxP3. The stromal immune infiltrate density was qualitatively scored as a percentage of tumor area: 1+ (<5%); 2+ (5-10%); 3+ (10-15%); or 4+ (>50%)...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28720418/invasive-lobular-breast-carcinoma-pleomorphic-versus-classical-subtype-associations-and%C3%A2-prognosis
#10
Ying L Liu, Christine Choi, Shing M Lee, Xiaobo Zhong, Hanina Hibshoosh, Kevin Kalinsky, Eileen P Connolly
BACKGROUND: Invasive pleomorphic lobular carcinoma (IPLC) has been associated with a worse prognosis compared with classic invasive lobular carcinoma (cILC); however, studies are small and conflicting. We seek to examine the prognosis of women with IPLC compared with cILC. METHODS: A retrospective review of women with breast cancer at a single institution from 2003 to 2012 identified 193 women with invasive lobular carcinoma (ILC). IPLC was defined as ILC with a pathological description of primarily pleomorphic features and Nottingham histological grade score of 7, 8, or 9 or overall grade of 3 or mixed classic/pleomorphic features and overall grade of 3...
June 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28705168/relevance-of-breast-mri-in-determining-the-size-and-focality-of-invasive-breast-cancer-treated-by-mastectomy-a-prospective-study
#11
Anne-Julie Carin, Sébastien Molière, Victor Gabriele, Massimo Lodi, Nicolas Thiébaut, Karl Neuberger, Carole Mathelin
BACKGROUND: The aim of this study was the evaluation of breast MRI in determining the size and focality of invasive non-metastatic breast cancers. METHODS: The prospective, single-centre study conducted in 2015 compared preoperative MRI with histological analysis of mastectomy. RESULTS: One hundred one mastectomies from 98 patients were extensively analysed. The rates of false-positive and false-negative MRI were 2 and 4% respectively. The sensitivity of breast MRI was 84...
July 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28691862/simplifying-breast-imaging-reporting-and-data-system-classification-of-mammograms-with-pure-suspicious-calcifications
#12
Gisela Lg Menezes, Gonneke Ao Winter-Warnars, Eva L Koekenbier, Emma J Groen, Helena M Verkooijen, Ruud M Pijnappel
Objectives To investigate the risk of malignancy following stereotactic breast biopsy of calcifications classified as Breast Imaging Reporting and Data System (BI-RADS) 3, 4, and 5. Methods The study included women with pure calcifications (not associated with masses or architectural distortions) who underwent stereotactic breast biopsy at the Dutch Cancer Institute between January 2011 and October 2013. Suspicious calcifications (Breast Imaging Reporting and Data System 3, 4, or 5) detected on mammography were biopsied...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28690654/the-usefulness-of-intraoperative-circumferential-frozen-section-analysis-of-lumpectomy-margins-in-breast-conserving-surgery
#13
SeungSang Ko, Yi Kyeong Chun, Sung Soo Kang, Min Hee Hur
PURPOSE: Intraoperative frozen-section analysis of the lumpect-omy margin during breast-conserving surgery (BCS) is an excellent method in obtaining a clear resection margin. This study aimed to investigate the usefulness of intraoperative circumferential frozen-section analysis (IOCFS) of lumpectomy margin during BCS for breast cancer, and to find factors that increase the conversion into mastectomy. METHODS: From 2007 to 2011, 509 patients with breast cancer underwent IOCFS during BCS...
June 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28688723/focally-positive-margins-in-breast-conserving-surgery-predictors-residual-disease-and-local-recurrence
#14
E L Vos, J Gaal, C Verhoef, K Brouwer, C H M van Deurzen, L B Koppert
BACKGROUND: Re-excision after breast conserving surgery (BCS) for invasive breast cancer (IBC) can be omitted for focally positive margins in the Netherlands, but this guideline is not routinely followed. Focally positive and extensively positive margins have rarely been studied separately and compared to negative margins regarding clinicopathological predictors, residual disease incidence, and local recurrence. METHODS: All females with BCS for Tis-T3, without neo-adjuvant chemotherapy between 2005 and 2014 at one university hospital were included...
June 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28687693/adrenal-crisis-in-metastatic-breast-cancer
#15
Bernhard Doleschal, Andreas Petzer, Karl J Aichberger
A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28679771/neratinib-efficacy-and-circulating-tumor-dna-detection-of-her2-mutations-in-her2-non-amplified-metastatic-breast-cancer
#16
Cynthia X Ma, Ron Bose, Feng Gao, Rachel A Freedman, Melinda L Telli, Gretchen Kimmick, Eric P Winer, Michael J Naughton, Matthew P Goetz, Christy Russell, Debu Tripathy, Melody Cobleigh, Andres Forero, Timothy J Pluard, Carey K Anders, Polly Niravath, Shana Thomas, Jill Anderson, Caroline Bumb, Kimberly C Banks, Richard B Lanman, Richard Bryce, Alshad S Lalani, John D Pfeifer, Daniel F Hayes, Mark D Pegram, Kimberly Blackwell, Phillipe L Bedard, Hussam Al-Kateb, Matthew J Ellis
Based on promising preclinical data, we conducted a single arm phase II trial to assess the clinical benefit rate (CBR) of neratinib, defined  as complete/partial response (CR/PR) or stable disease (SD) ≥24 weeks, in HER2(mut) non-amplified metastatic breast cancer (MBC).  Secondary endpoints included progression-free survival (PFS), toxicity, and circulating tumor DNA (ctDNA) HER2(mut) detection.  <p>Experimental Methods:  Tumor tissue positive for HER2(mut) was required for eligibility.  Neratinib was administered 240mg daily with prophylactic loperamide...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28679405/colonic-metastasis-from-breast-carcinoma-a-case-report
#17
Kazuma Tsujimura, Tsuyoshi Teruya, Masaya Kiyuna, Kuniki Higa, Junko Higa, Kouji Iha, Kiyoshi Chinen, Masaya Asato, Yasukatsu Takushi, Morihito Ota, Eijirou Dakeshita, Atsushi Nakachi, Akira Gakiya, Hiroshi Shiroma
BACKGROUND: Colonic metastasis from breast carcinoma is very rare. Here, we report a case of colonic metastasis from breast carcinoma. CASE PRESENTATION: The patient was a 51-year-old woman. She had upper abdominal pain, vomiting, and diarrhea, repeatedly. We performed abdominal contrast-enhanced computed tomography (CT) to investigate these symptoms. The CT scan revealed a tumor in the ascending colon with contrast enhancement and showed an expanded small intestine...
July 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28670070/two-cancers-in-one-breast-carcinoma-with-underlying-melanoma
#18
Nicholas A Douville, Elizabeth A Sakach, Elizabeth A Wiewiorowski, William Herlihy, John E Pippen
A 61-year-old woman presented with a diagnosis of metastatic invasive lobular carcinoma of the right breast, and after treatment it had regressed or was stable except for a scalp nodule. When biopsied, the outer edges of the scalp lesion had findings consistent with breast carcinoma; however, the bulk of the tumor's pathology was consistent with melanoma. It appeared that most of the tumor was a highly vascularized melanoma with lobular breast carcinoma noted at its edges.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28661577/atypical-uterine-cervix-metastases-from-invasive-lobular-carcinoma-of-the-breast
#19
Carmen Parrilla, Israel Barco, Ares Pedrerol, Antoni Pessarrodona, Nuria Giménez, Antonio García-Fernández
No abstract text is available yet for this article.
June 29, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28659177/a-bayesian-network-and-heuristic-approach-for-systematic-characterization-of-radiotherapy-receipt-after-breast-conservation-surgery
#20
Milton Soto-Ferrari, Diana Prieto, Gitonga Munene
BACKGROUND: Breast-conservation surgery with radiotherapy is a treatment highly recommended by the guidelines from the National Comprehensive Cancer Network. However, several variables influence the final receipt of radiotherapy and it might not be administered to breast cancer patients. Our objective is to propose a systematic framework to identify the clinical and non-clinical variables that influence the receipt of unexpected radiotherapy treatment by means of Bayesian networks and a proposed heuristic approach...
June 28, 2017: BMC Medical Informatics and Decision Making
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