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https://www.readbyqxmd.com/read/28210090/efficacy-and-safety-of-stellate-ganglion-block-in-chronic-ulcerative-colitis
#1
Hong-Ying Zhao, Guo-Tao Yang, Ning-Ning Sun, Yu Kong, Yun-Feng Liu
AIM: To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis. METHODS: A total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group (n = 30), patients received oral sulfasalazine treatment; experimental group (n = 90), patients received stellate ganglion block treatment...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28179619/rituximab-can-induce-remission-in-a-patient-with-ankylosing-spondylitis-who-failed-anti-tnf-%C3%AE-agent
#2
Fahmi AlDhaheri, Talal Almteri, Naji Dwid, Ahd Majdali, Nahed Janoudi, Hani Almoallim
BACKGROUND Ankylosing spondylitis (AS) is a chronic inflammatory disease that predominantly affects the axial skeleton. The ability of anti-TNF-α agents to reduce disease activity in patients with axial spondyloarthritis (axSpA), including AS, has been demonstrated in multiple randomized trials and several meta-analyses. Reports on the efficacy of rituximab in treatment of AS have described good results. We report on a patient with AS who failed anti-TNF-α therapy but showed good clinical improvement with rituximab therapy...
February 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28167131/erythropoietin-induced-cytoprotection-in-intestinal-epithelial-cells-is-linked-to-system-xc
#3
Colin Martin, Mikita Patel, Miguel Melendez-Ferro, Brian Sims
Necrotizing enterocolitis is a common but serious complication among premature babies. Currently, there are limited treatment options. These include intensive supportive care and surgical intervention. In this study, we hypothesize that erythropoietin (Epo) could be protective against cell necrosis by increasing the levels of glutathione. This can be regulated by increasing the activity of system xC(-). This was demonstrated using intestinal epithelial cells (IEC-6) as a model system. S4-CPG and sulfasalazine pharmacologically inhibit xCT, which induced cell death...
February 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28166785/a-comparison-of-three-treatment-strategies-in-recent-onset-non-systemic-juvenile-idiopathic-arthritis-initial-3-months-results-of-the-best-for-kids-study
#4
P C E Hissink Muller, D M C Brinkman, D Schonenberg, Y Koopman-Keemink, I C J Brederije, W P Bekkering, T W Kuijpers, M A J van Rossum, L W A van Suijlekom-Smit, J M van den Berg, C F Allaart, R Ten Cate
BACKGROUND: Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthritis (JIA) patients. Here we present three months clinical outcome of initial treatments of the BeSt-for-Kids study. METHODS: Included patients were randomized to either: 1. initial DMARD-monotherapy (sulfasalazine (SSZ) or methotrexate (MTX)), 2...
February 6, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28146003/comparative-effectiveness-of-mesalamine-sulfasalazine-corticosteroids-and-budesonide-for-the-induction-of-remission-in-crohn-s-disease-a-bayesian-network-meta-analysis
#5
Stephanie Coward, M Ellen Kuenzig, Glen Hazlewood, Fiona Clement, Kerry McBrien, Rebecca Holmes, Remo Panaccione, Subrata Ghosh, Cynthia H Seow, Ali Rezaie, Gilaad G Kaplan
BACKGROUND: Induction treatment of mild-to-moderate Crohn's disease is controversial. PURPOSE: To compare the induction of remission between different doses of mesalamine, sulfasalazine, corticosteroids, and budesonide for active Crohn's disease. DATA SOURCES: We identified randomized controlled trials from existing Cochrane reviews and an updated literature search in Medline, EMBASE, and CENTRAL to November 2015. STUDY SELECTION: We included randomized controlled trials (n = 22) in adult patients with Crohn's disease that compared budesonide, sulfasalazine, mesalamine, or corticosteroids with placebo or each other, for the induction of remission (8-17 wks)...
January 31, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28138822/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-and-the-rheumatologist
#6
REVIEW
Marwan H Adwan
PURPOSE OF THE REVIEW: The purpose of the review is to summarise the various drugs used in rheumatology practice implicated in the causation of DRESS syndrome. RECENT FINDINGS: The most commonly reported drugs are allopurinol, sulfasalazine and minocycline, which pose a very high risk for DRESS syndrome development, followed by strontium ranelate and dapsone. Other, less commonly reported, drugs include leflunomide, hydroxychloroquine, non-steroidal anti-inflammatory drugs, febuxostat, bosentan and solcitinib...
January 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#7
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28123782/systematic-review-and-network-meta-analysis-of-the-efficacy-and-safety-of-tumour-necrosis-factor-inhibitor-methotrexate-combination-therapy-versus-triple-therapy-in-rheumatoid-arthritis
#8
Roy Fleischmann, Vanita Tongbram, Ronald van Vollenhoven, Derek H Tang, James Chung, David Collier, Shilpa Urs, Kerigo Ndirangu, George Wells, Janet Pope
OBJECTIVE: Clinical trials have not consistently demonstrated differences between tumour necrosis factor inhibitor (TNFi) plus methotrexate and triple therapy (methotrexate plus hydroxychloroquine plus sulfasalazine) in rheumatoid arthritis (RA). The study objective was to estimate the efficacy, radiographic benefits, safety and patient-reported outcomes of TNFi-methotrexate versus triple therapy in patients with RA. METHODS: A systematic review and network meta-analysis (NMA) of randomised controlled trials of TNFi-methotrexate or triple therapy as one of the treatment arms in patients with an inadequate response to or who were naive to methotrexate was conducted...
2017: RMD Open
https://www.readbyqxmd.com/read/28121807/sulfasalazine-related-hypersensitivity-reactions-in-patients-with-rheumatic-diseases
#9
Songul Cildag, Taskin Senturk
BACKGROUND: Sulfasalazine (SSZ), which has an arylamine sulfonamide structure, is an anti-inflammatory drug used in the treatment of many rheumatic diseases. Various adverse effects have been reported related to SSZ. In the present study, we aimed to define the frequency of SSZ-related hypersensitivity reaction in patients with rheumatoid arthritis and ankylosing spondylitis. METHODS: A total of 136 patients were included in this study. During follow-ups, reaction type, reaction duration, and drug doses were recorded in patients who developed hypersensitivity reactions...
January 24, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28120908/behavioural-effects-of-using-sulfasalazine-to-inhibit-glutamate-released-by-cancer-cells-a-novel-target-for-cancer-induced-depression
#10
Mina G Nashed, Robert G Ungard, Kimberly Young, Natalie J Zacal, Eric P Seidlitz, Jennifer Fazzari, Benicio N Frey, Gurmit Singh
Despite the lack of robust evidence of effectiveness, current treatment options for cancer-induced depression (CID) are limited to those developed for non-cancer related depression. Here, anhedonia-like and coping behaviours were assessed in female BALB/c mice inoculated with 4T1 mammary carcinoma cells. The behavioural effects of orally administered sulfasalazine (SSZ), a system xc(-) inhibitor, were compared with fluoxetine (FLX). FLX and SSZ prevented the development of anhedonia-like behaviour on the sucrose preference test (SPT) and passive coping behaviour on the forced swim test (FST)...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28119098/anti-inflammatory-effects-of-brucea-javanica-oil-emulsion-by-suppressing-nf-%C3%AE%C2%BAb-activation-on-dextran-sulfate-sodium-induced-ulcerative-colitis-in-mice
#11
Yan-Feng Huang, Jiang-Tao Zhou, Chang Qu, Yao-Xing Dou, Qiong-Hui Huang, Zhi-Xiu Lin, Yan-Fang Xian, Jian-Hui Xie, You-Liang Xie, Xiao-Ping Lai, Zi-Ren Su
ETHNOPHARMACOLOGICAL RELEVANCE: Brucea javanica is an important traditional medicinal herb used for the treatment of dysentery, malaria, inflammation and cancer in southeast Asia for many years. However, the anti-inflammatory mechanism of Brucea javanica in the treatment of dysentery (also known as ulcerative colitis, UC) has not been fully illuminated. Brucea javanica oil emulsion (BJOE) is the major active and most common application form of Brucea javanica oil (BJO), which has a variety of pharmacological activities...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28110377/sulfasalazine-in-prevention-of-pouchitis-after-proctocolectomy-with-ileal-pouch-anal-anastomosis-for-ulcerative-colitis
#12
Eleonora Scaioli, Alessandro Sartini, Elisa Liverani, Richard John Digby, Giampaolo Ugolini, Giancarlo Rosati, Gilberto Poggioli, Davide Festi, Franco Bazzoli, Andrea Belluzzi
BACKGROUND: Pouchitis is the most frequent complication after ileal pouch-anal anastomosis for refractory ulcerative colitis. A non-standardized preventative treatment exists. Sulfasalazine has proved effective in acute pouchitis therapy. AIMS: The aim of this study was to retrospectively evaluate the effect of sulfasalazine in primary prophylaxis of pouchitis after proctocolectomy with ileal pouch-anal anastomosis. METHODS: Data files of patients who underwent total proctocolectomy with ileal pouch-anal anastomosis for refractory ulcerative colitis and/or dysplasia from January 2007 to December 2014, with a follow-up until August 2015, were analyzed...
January 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28107918/bismuth-nanoparticles-carbon-nanotubes-modified-sensor-for-sulfasalazine-analysis
#13
Biljana Nigović, Sandra Jurić, Iva Mitrović
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti-inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28104973/unusual-case-of-an-alcoholic-with-liver-injury-from-sulfasalazine-use
#14
Umair Masood, Anuj Sharma, Sonny Nijjar, Barbara Krenzer
A 57-year-old male with a history of alcoholism presented to the emergency room with abdominal pain, jaundice, transaminitis, and hyperbilirubinemia. Due to the history of alcoholism, it was initially presumed that the patient had alcoholic hepatitis but further investigation revealed that he was recently started on sulfasalazine for the treatment of rheumatoid arthritis. Upon cessation of the drug, the patient's liver function tests significantly improved over a few days and eventually normalized within weeks...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28089501/effectiveness-of-conventional-disease-modifying-antirheumatic-drugs-in-psoriatic-arthritis-a-systematic-review
#15
Jesús Maese, Petra Díaz Del Campo, Daniel Seoane-Mato, Mercedes Guerra, Juan D Cañete
BACKGROUND: Due to the clinical heterogeneity of psoriatic arthritis (PsA), recommendations have been developed by international groups to guide therapeutic decisions of the rheumatologist. The objective of the current systematic review (RS) was to evaluate the evidence of efficacy of disease-modifying antirheumatic drugs (DMARDs) in PsA. METHODS: Literature search in Medline, EMBASE, Cochrane Library, from 2008 to 2014. We included RS, randomized clinical trials and observational studies, in patients with PsA and an evaluation of efficiency of conventional DMARDs (methotrexate, sulfasalazine, leflunomide), according to the following outcomes: peripheral and axial symptoms; peripheral radiological damage; enthesitis according to power Doppler ultrasound or magnetic resonance imaging (enthesitis count before and after therapy); dactylitis; uveitis...
January 13, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28054726/sustainable-synthesis-of-balsalazide-and-sulfasalazine-based-on-diazotization-with-low-concentrated-nitrogen-dioxide-in-air
#16
Markus Rolf Heinrich, Dagmar Hofmann, Eva Gans, Jasmin Krüll
Low concentrated nitrogen dioxide, which arises as side product from a range of industrial processes, can effectively be recycled through the diazotization of anilines. The studies reported herein now demonstrate that the removal of nitrogen dioxide from gas streams is even more effective when hydrophilic anilines are used as starting materials. The diazonium salts, which are obtained in this way in up to quantitative yields, can directly be employed in azo coupling reactions, thus opening an attractive access to the industrially important group of azo compounds...
January 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28007652/characteristics-of-sulfasalazine-induced-cytotoxicity-in-c6-rat-glioma-cells
#17
Raffaela Silvestre Ignarro, Gustavo Facchini, Daniela Rodrigues de Melo, Karin Juliane Pelizzaro-Rocha, Carmen Veríssima Ferreira, Roger Frigério Castilho, Fabio Rogerio
Glioblastoma is the most aggressive primary brain tumor. Surgical resection, radiotherapy and temozolomide (TMZ), an alkylating agent, is the standard of care. Glioma cells may synthetize the antioxidant glutathione by importing cystine through a cystine/glutamate antiporter, which is inhibited by sulfasalazine (SAS). C6 rat glioma cells are largely used in in vitro and in vivo models for developing new glioblastoma treatment strategies. We treated C6 cells with 25μM TMZ and/or 0.25mM or 0.5mM SAS for 1, 3 or 5days and evaluated viability, apoptosis, total glutathione levels and metalloproteinase MMP2 and MMP9 activities...
December 19, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28001233/candida-arthritis-in-a-patient-diagnosed-with-spondyloarthritis
#18
Remzi Çevik, Recep Tekin, Mehmet Gem
Candida arthritis is an unusual manifestation that usually affects the knees. A 35-year-old man presented with a 2-month history of pain and swelling in the right knee. Swelling persisted after anti-inflammatory treatment. Peripheric spondyloarthritis was considered, but methotrexate, sulfasalazine, and methylprednisolone did not reduce the swelling. Direct examination of synovial fluid and a culture were positive for Candida albicans. Intravenous and intra-articular amphotericin-B were administered. The arthritis regressed and a culture and direct staining showed negative results...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27992691/a-multi-biomarker-disease-activity-score-and-the-choice-of-second-line-therapy-in-early-rheumatoid-arthritis-after-methotrexate-failure
#19
Karen Hambardzumyan, Saedis Saevarsdottir, Kristina Forslind, Ingemar F Petersson, Johan K Wallman, Sofia Ernestam, Rebecca J Bolce, Ronald F van Vollenhoven
OBJECTIVE: We investigated whether the multi-biomarker disease activity (MBDA) score predicts optimal add-on treatment in methotrexate-inadequate-responders (MTX-IR) in early rheumatoid arthritis (RA). METHODS: We analysed 157 MTX-IRs (28-joint disease activity score based on erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Farmacotherapy (SWEFOT) trial who were randomized to triple therapy (TT [MTX+sulfasalazine+hydroxychloroquine]) versus MTX+infliximab...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27989589/efficacy-of-triple-association-methotrexate-sulfasalazine-and-hydroxychloroquine-in-early-treatment-of-rheumatoid-arthritis-with-insufficient-response-to-methotrexate-meta-analysis-of-randomized-controlled-trials
#20
Arnaud Mazouyès, Marine Clay, Anne-Catherine Bernard, Philippe Gaudin, Athan Baillet
OBJECTIVES: To evaluate the efficacy of the triple synthetic Disease Modifying Anti-Rheumatic Drugs (sDMARD) combination methotrexate, sulfasalazine and hydroxychloroquine versus a biologic DMARD (bDMARD) in the treatment of early rheumatoid arthritis. METHODS: A systematic literature search was performed using the PubMed and Cochrane databases, and abstracts presented at rheumatology scientific meetings until December 2013. Randomized controlled trials comparing the efficacy and the safety of biologic DMARD with the triple combination were included...
December 15, 2016: Joint, Bone, Spine: Revue du Rhumatisme
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