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https://www.readbyqxmd.com/read/27886691/pharmacotherapy-pearls-for-the-geriatrician-focus-on-oral-disease-modifying-antirheumatic-drugs-including-newer-agents
#1
REVIEW
Ann J Biehl, James D Katz
Providing safe and effective pharmacotherapy to the geriatric patients with rheumatological disorders is an ongoing struggle for the rheumatologist and geriatrician alike. Cohesive communication and partnership can improve the care of these patients and subvert adverse outcomes. Disease-modifying antirheumatic drugs, including methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide, and the newest oral agent for treatment of rheumatoid arthritis, tofacitinib, have distinctive monitoring and adverse effect profiles...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27851691/case-of-nod2-associated-autoinflammatory-disease-successfully-treated-with-sulfasalazine
#2
Maya Estephan, Qingping Yao, Jason Springer
No abstract text is available yet for this article.
November 16, 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27847249/a-novel-heterogeneous-system-for-sulfate-radical-generation-through-sulfite-activation-on-a-cofe2o4-nanocatalyst-surface
#3
Zizheng Liu, Shaojie Yang, Yanan Yuan, Jing Xu, Yifan Zhu, Jinjun Li, Feng Wu
Heterogeneous catalytic activation is important for potential application of new sulfate-radical-based advanced oxidation process using sulfite as source of sulfate radical. We report herein a heterogeneous system for sulfite activation by CoFe2O4 nanocatalyst for metoprolol removal. Factors that influence metoprolol removal were investigated, including pH and initial concentrations of components. The CoFe2O4 nanocatalyst was characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM), and the catalytic stability was tested by consecutive runs...
November 10, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27843370/rheumatoid-arthritis-in-patients-with-hiv-management-challenges
#4
REVIEW
Matthew B Carroll, Joshua H Fields, Philip G Clerc
Over the past few decades, HIV has been transformed from a once-uniformly fatal disease to now a manageable but complex multisystem illness. Before highly active antiretroviral therapy (HAART), reports suggested that HIV-infected patients with rheumatoid arthritis (RA) would experience remission of their disease. It has now become clear that RA can develop in HIV-infected patients at any time, independent of HAART. Choosing the right medication to treat symptoms related to RA while avoiding excess weakening of the immune system remains a clinical challenge...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27822501/inhibition-of-ikk%C3%AE-reduces-ethanol-consumption-in-c57bl-6j-mice
#5
Jay M Truitt, Yuri A Blednov, Jillian M Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W Lasek, R Adron Harris, R Dayne Mayfield
Proinflammatory pathways in neuronal and non-neuronal cells are implicated in the acute and chronic effects of alcohol exposure in animal models and humans. The nuclear factor-κB (NF-κB) family of DNA transcription factors plays important roles in inflammatory diseases. The kinase IKKβ mediates the phosphorylation and subsequent proteasomal degradation of cytosolic protein inhibitors of NF-κB, leading to activation of NF-κB. The role of IKKβ as a potential regulator of excessive alcohol drinking had not previously been investigated...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27813290/identifying-clinical-factors-associated-with-low-disease-activity-and-remission-of-rheumatoid-arthritis-during-pregnancy
#6
Hilal Ince-Askan, Johanna M W Hazes, Radboud J E M Dolhain
OBJECTIVES: To identify a combination of clinical factors associated with low disease activity and remission in the third trimester during pregnancy in women with Rheumatoid Arthritis(RA). METHODS: This study is embedded in the Pregnancy induced Amelioration of Rheumatoid Arthritis(PARA)-study, a prospective cohort study. There was data available on 190 pregnancies from first trimester unto delivery. Multivariate regression analyses were performed on the disease activity(DAS28-CRP3) in the third trimester...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27800496/serum-hmgb1-serves-as-a-novel-laboratory-indicator-reflecting-disease-activity-and-treatment-response-in-ankylosing-spondylitis-patients
#7
Chenqiong Wang, Ye Miao, Xuefen Wu, Yishu Huang, Mengchen Sun, Yingzi Zhu, Fang Zheng, Wei Sun, Lingli Dong
Objective. High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and inflammatory diseases. In the current study, we analyzed the association between serum levels of HMGB1 and clinical features of AS patients before and during treatment. Methods. Serum HMGB1 was detected in 147 AS patients and 61 healthy controls using ELISA. We evaluated the association between HMGB1 and extra-articular manifestations as well as disease severity indices. Among these AS patients, 41 patients received close follow-up at 1, 3, and 6 months after treatment...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27783843/azathioprine-or-6-mercaptopurine-for-induction-of-remission-in-crohn-s-disease
#8
REVIEW
Nilesh Chande, Cassandra M Townsend, Claire E Parker, John K MacDonald
BACKGROUND: The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treatment of active Crohn's disease have been conflicting and controversial. An updated meta-analysis was performed to assess the effectiveness of these drugs for the induction of remission in active Crohn's disease. OBJECTIVES: The primary objective was to determine the efficacy and safety of azathioprine and 6-mercaptopurine for induction of remission in active Crohn's disease...
October 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27778097/sulfasalazine-induced-immune-thrombocytopenia-in-a-patient-with-rheumatoid-arthritis
#9
Nehal Narayan, Shirley Rigby, Francesco Carlucci
Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune thrombocytopenia and review the mechanisms behind drug-induced immune thrombocytopenia (DITP) and the approach to its diagnosis and management.
October 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27773320/production-of-pyrite-nanoparticles-using-high-energy-planetary-ball-milling-for-sonocatalytic-degradation-of-sulfasalazine
#10
Alireza Khataee, Siavash Fathinia, Mehrangiz Fathinia
Sonocatalytic performance of pyrite nanoparticles was evaluated by the degradation of sulfasalazine (SSZ). Pyrite nanoparticles were produced via a high energy mechanical ball milling (MBM) in different processing time from 2h to 6h, in the constant milling speed of 320rpm. X-ray diffraction (XRD), scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FT-IR) analysis and Brunauer-Emmett-Teller (BET) confirmed the production of pyrite nanoparticles during 6h of ball milling with the average size distribution of 20-80nm...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27771081/goat-whey-ameliorates-intestinal-inflammation-on-acetic-acid-induced-colitis-in-rats
#11
Daline Fernandes de Souza Araújo, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo Júnior, Aurigena Antunes de Araújo, Paloma Oliveira Antonino de Assis, Ariosvaldo Nunes de Medeiros, Yasmim Regis Formiga de Sousa, Maria Manuela Estevez Pintado, Julio Gálvez, Rita de Cássia Ramos do Egypto Queiroga
Complementary or alternative medicine is of great interest for the treatment of inflammatory bowel disease, with the aim of ameliorating the side effects of the drugs commonly used or improving their efficacy. In this study, we evaluated the ability of goat whey to prevent intestinal inflammation in the experimental model of acetic acid-induced rats and compared it to sulfasalazine. Pretreatment with goat whey (1, 2, and 4 g/kg) and sulfasalazine (250 mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1β and tumor necrosis factor-α...
October 19, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27769943/mucoadhesive-chitosan-hydrogels-as-rectal-drug-delivery-vessels-to-treat-ulcerative-colitis
#12
Jinke Xu, Mifong Tam, Sepideh Samaei, Sophie Lerouge, Jake Barralet, Mary M Stevenson, Marta Cerruti
: Mucoadhesive drug delivery systems stick to mucosal tissues and prolong the local retention time of drugs. Since the colon is covered by a mucosal layer, mucoadhesive rectal formulations may improve treatment of such diseases as hypertension or colon cancer. Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the colonic mucosa. It is commonly treated with sulfasalazine (SSZ), which is metabolized by the intestinal flora into the therapeutic 5-aminosalicylic acid (5-ASA) and a toxic by-product sulfapyridine (SP)...
October 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27749226/update-on-malignancies-in-children-with-juvenile-idiopathic-arthritis-in-the-german-biker-registry
#13
Gerd Horneff, Ariane Klein, Prasad T Oommen, Anton Hospach, Ivan Foeldvari, Isa Feddersen, Kirsten Minden
OBJECTIVES: While tumour necrosis factor (TNF)-α-inhibitor treatment improved outcome of juvenile idiopathic arthritis (JIA) management markedly, concerns have been raised about an association of TNF-α-inhibitor treatment and an increased risk for malignancies especially lymphoma. METHODS: Cases of suspected malignancies documented in the German Biker Registry are reviewed in detail. RESULTS: Until Dec 31, 2015, 3695 JIA patients were prospectively followed with a total of more than 13,198 observation years...
September 8, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27746265/the-comparative-safety-of-multiple-alternative-agents-in-refractory-chronic-urticaria-patients
#14
Sharon Seth, David A Khan
BACKGROUND: Patients who have failed traditional treatment of chronic urticaria may require trials of alternative medications. Safety profiles, continuous laboratory monitoring, and physician comfort are often barriers to treatment. OBJECTIVES: To evaluate the safety of alternative agents used in chronic urticaria. METHODS: A retrospective chart review of electronic medical records from a single-center allergy and immunology clinic in a major academic hospital was conducted...
October 13, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27739352/preterm-birth-in-women-with-inflammatory-bowel-disease-the-association-with-disease-activity-and-drug-treatment
#15
Gabriella Bröms, Fredrik Granath, Olof Stephansson, Helle Kieler
BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) have been associated with an increased risk of preterm birth. MATERIAL AND METHODS: We identified all 246 singleton preterm births among women with IBD between July 2006 and December 2010 as cases and an equal number of controls with IBD from the Swedish national health registers, matched by maternal age, parity and IBD diagnosis (CD/UC). From register data and medical charts, we obtained information on reproductive history, comorbidity, disease activity and drug treatment (corticosteroids, 5-aminosalicylates, sulfasalazine, thiopurines and anti-TNF) as risk factors for preterm birth...
December 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27729929/assessment-of-collagen-antibody-induced-arthritis-in-balb-c-mice-using-bioimaging-analysis-and-histopathological-examination
#16
Joo Hye Sim, Won Kil Lee, Yun Seok Lee, Jin Seok Kang
The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided into five groups: group 1 (G1): control, group 2 (G2): probe control, group 3 (G3): CAIA, group 4 (G4): CAIA+sulfasalazine (10 mg/kg, oral), and group 5 (G5): CAIA+prednisolone (100 mg/kg, oral). Fluorescence bioimaging was performed in vivo 24 and 48 h after treatment with a fluorescence probe (OsteoSense® 680 EX), and all mice were sacrificed...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729768/efficacy-of-an-acquainted-drug-in-the-treatment-of-inflammatory-low-back-pain-sulfasalazine-under-investigation
#17
Jamileh Moghimi, Ali Asghar Rezaei, Raheb Ghorbani, Mohammad Reza Razavi, Daryoush Pahlevan
In the current study, the overall prevalence and the main underlying etiologies of inflammatory low back pain (ILBP) were determined, and the effectiveness of treatment with sulfasalazine was investigated in patients with inflammatory versus mechanical low back pain (LBP). In a prospective study conducted from July 2013 until August 2015, 1,779 consecutive patients within the age range of 18-50 years with a primary complaint of LBP referring to the rheumatology clinics were included. The patients were classified into two distinct groups: those suffering from ILBP (n=118) and those having mechanical LBP (n=1,661)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27725926/management-of-inflammatory-bowel-disease-during-pregnancy-and-breastfeeding-varies-widely-a-need-for-further-education
#18
Vivian Wai-Mei Huang, Hsiu-Ju Chang, Karen Ivy Kroeker, Karen Jean Goodman, Kathleen M Hegadoren, Levinus Albert Dieleman, Richard Neil Fedorak
Background. Inflammatory bowel disease (IBD) affects patients in their young reproductive years. Women with IBD require maintenance therapies during pregnancy and breastfeeding. However, physician management of IBD during pregnancy and breastfeeding has not been well characterized. Objective. To characterize physician perceptions and management of IBD during pregnancy and breastfeeding. Methods. A cross-sectional survey of Canadian physicians who are involved in the care of women with IBD was conducted. The survey included multiple-choice and Likert scale questions about perceptions and practice patterns regarding the management of IBD during pregnancy and breastfeeding...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27718119/successful-colonoscopic-fecal-microbiota-transplantation-for-active-ulcerative-colitis-first-report-from-india
#19
Avnish Kumar Seth, Pawan Rawal, Ruchika Bagga, Priti Jain
Forty-four-year-old male with ulcerative colitis (UC) for 11 years reported frequent relapse despite daily sulfasalazine 4 g, azathioprine 125 mg, and rectal 5-aminosalicylic acid. Repeated use of corticosteroids led to cataract. At enrollment, he was passing eight stools a day with blood with a Mayo score of 9 (3+1+3+2). Stool was negative for ova/cysts/acid fast bacilli and Clostridium difficile toxin assay. Rectal biopsy showed cryptitis, crypt abscess, and crypt distortion with no inclusion bodies, and cytomegalovirus DNA was negative...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27716592/discovery-and-preclinical-development-of-a-novel-prodrug-conjugate-of-mesalamine-with-eicosapentaenoic-acid-and-caprylic-acid-for-the-treatment-of-inflammatory-bowel-diseases
#20
Mahesh Kandula, K B Sunil Kumar, Sivanesan Palanichamy, Ashok Rampal
Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission. Sulfasalazine and formulations of 5-ASA (pH-dependent and controlled release formulations) were developed to minimize the systemic absorption and maximize the delivery of the mesalamine to colon. Although, its efficacy and safety is well documented there are approximately 30% nonresponders to 5-ASA therapy. This necessitates the need for novel therapeutic options to improve the efficacy and safety of the currently available 5-ASA therapy...
October 4, 2016: International Immunopharmacology
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