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https://www.readbyqxmd.com/read/28427847/tetanus-vaccines-who-position-paper-february-2017-recommendations
#1
(no author information available yet)
This article presents the World Health Organization's (WHO) recommendations on the use of tetanus toxoid (TT) vaccines excerpted from the WHO position paper on tetanus vaccines - February 2017, published in the Weekly Epidemiological Record [1]. This position paper replaces the May 2006 WHO position paper on tetanus vaccines (Tetanus vaccines: WHO position paper, 2006). The position paper summarizes the recent developments in the field of tetanus prevention and provides revised guidance on the optimal timing of recommended tetanus vaccine booster doses...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28414328/marginal-zone-b-cells-control-the-response-of-follicular-helper-t-cells-to-a-high-cholesterol-diet
#2
Meritxell Nus, Andrew P Sage, Yuning Lu, Leanne Masters, Brian Y H Lam, Stephen Newland, Sandra Weller, Dimitrios Tsiantoulas, Juliette Raffort, Damiënne Marcus, Alison Finigan, Lauren Kitt, Nichola Figg, Reinhold Schirmbeck, Manfred Kneilling, Giles S H Yeo, Christoph J Binder, José Luis de la Pompa, Ziad Mallat
Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol diet (HCD) and regulate both the differentiation and accumulation of T follicular helper (TFH) cells. Feeding mice an HCD resulted in upregulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner and increased the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and suppression of the proatherogenic TFH response...
April 17, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28401429/learning-at-large-conferences-from-the-sage-on-the-stage-to-contemporary-models-of-learning
#3
Dario Torre, Annalisa Manca, Steven Durning, Janusz Janczukowicz, David Taylor, Jennifer Cleland
AIM: To explore and evaluate the affordances of a flipped classroom model applied to a research paper session within the professional development opportunity of a large conference setting. METHOD: Authors were invited to present their research papers in a flipped classroom presentation format at two large, multi-national conferences. Before the session, authors and moderators met online to clarify features of the session, and preparation of the material. The research material was then posted online before the conference, to allow access by meeting attendees...
April 11, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28400797/targeting-amyloid-precursor-protein-shuttling-and-processing-long-before-amyloid-beta-formation
#4
Sage Arbor
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28399566/chronic-noncommunicable-diseases-in-6-low-and-middle-income-countries-findings-from-wave-1-of-the-world-health-organization-s-study-on-global-ageing-and-adult-health-sage
#5
Perianayagam Arokiasamy, Uttamacharya, Paul Kowal, Benjamin D Capistrant, Theresa E Gildner, Elizabeth Thiele, Richard B Biritwum, Alfred E Yawson, George Mensah, Tamara Maximova, Fan Wu, Yanfei Guo, Yang Zheng, Sebastiana Zimba Kalula, Aarón Salinas Rodríguez, Betty Manrique Espinoza, Melissa A Liebert, Geeta Eick, Kirstin N Sterner, Tyler M Barrett, Kwabena Duedu, Ernest Gonzales, Nawi Ng, Joel Negin, Yong Jiang, Julie Byles, Savathree Lorna Madurai, Nadia Minicuci, J Josh Snodgrass, Nirmala Naidoo, Somnath Chatterji
In this paper, we examine patterns of self-reported diagnosis of noncommunicable diseases (NCDs) and prevalences of algorithm/measured test-based, undiagnosed, and untreated NCDs in China, Ghana, India, Mexico, Russia, and South Africa. Nationally representative samples of older adults aged ≥50 years were analyzed from wave 1 of the World Health Organization's Study on Global Ageing and Adult Health (2007-2010; n = 34,149). Analyses focused on 6 conditions: angina, arthritis, asthma, chronic lung disease, depression, and hypertension...
March 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28399471/cigarette-smoke-extract-cse-induces-rage-mediated-inflammation-in-the-ca9-22-gingival-carcinoma-epithelial-cell-line
#6
Nolan T Sanders, Derek J Dutson, Justin W Durrant, Joshua B Lewis, Shalene H Wilcox, Duane R Winden, Juan A Arroyo, Benjamin T Bikman, Paul R Reynolds
OBJECTIVE: The oral environment is anatomically positioned as a significant gateway for exposure to environmental toxicants. Cigarette smoke exposure compromises oral health by orchestrating inflammation. The receptor for advanced glycation end-products (RAGE) has been implicated in smoke-induced inflammatory effects; however, its role in the oral cavity is unknown. The purpose of this study was to determine RAGE expression by immortalized gingival carcinoma cells and the degree to which RAGE-mediated signaling influences inflammation...
March 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28396704/emergency-department-stay-associated-delirium-in-older-patients
#7
Marcel Émond, David Grenier, Jacques Morin, Debra Eagles, Valérie Boucher, Natalie Le Sage, Éric Mercier, Philippe Voyer, Jacques S Lee
BACKGROUND: Caring for older patients can be challenging in the Emergency Department (ED). A > 12 hr ED stay could lead to incident episodes of delirium in those patients. The aim of this study was to assess the incidence and impacts of ED-stay associated delirium. METHODS: A historical cohort of patients who presented to a Canadian ED in 2009 and 2011 was randomly constituted. Included patients were aged ≥ 65 years old, admitted to any hospital ward, non-delirious upon arrival and had at least a 12-hour ED stay...
March 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28393274/chronic-n-enrichment-and-drought-alter-plant-cover-and-community-composition-in-a-mediterranean-type-semi-arid-shrubland
#8
George L Vourlitis
Anthropogenic nitrogen (N) deposition has caused a decline in native plant species and an increase in exotic plant species in many terrestrial ecosystems; however, vegetation change depends on the rate and/or duration of N input, individual species responses, interactions with other resources, and ecosystem properties such as species richness and canopy cover, soil texture, pH, and/or disturbance regime. Native shrub and exotic forb responses to N enrichment were evaluated over a 13-year field experiment in a mature coastal sage scrub (CSS) shrubland of southern California to test the hypothesis that dry-season N input will cause a decline in native shrubs and an increase in exotic annuals...
April 9, 2017: Oecologia
https://www.readbyqxmd.com/read/28389196/improving-guideline-compliance-in-australia-with-a-national-percutaneous-coronary-intervention-outcomes-registry
#9
David Eccleston, Mark Horrigan, Tony Rafter, Geoffrey Holt, Stephen G Worthley, Peter Sage, Alan Whelan, Christopher Reid, Peter L Thompson
BACKGROUND: Secondary prevention strategies after percutaneous coronary intervention (PCI) include statins and dual anti-platelet therapy, however there are significant gaps between guidelines and practice. Contemporary PCI practice requires comprehensive data collection to allow dynamic auditing and benchmarking of key performance and safety indices. Genesis HeartCare is Australia's largest collaborative venture of cardiologists, practising at over 40 public and private hospitals. We hypothesised that measurement and local reporting of data would improve patient outcomes through improving compliance with guideline therapies...
February 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28385607/malaria-vaccine-who-position-paper-january-2016-recommendations
#10
(no author information available yet)
This article presents the World Health Organization's (WHO) recommendations on the use of malaria vaccine excerpted from the WHO position paper on malaria vaccine published in the Weekly epidemiological Record in January 2016 [1]. The current document is the first WHO position paper on malaria vaccination and focuses primarily on the available evidence concerning the only malaria vaccine having received a positive regulation assessment from the European Medicines Agency (EMA) [2]. The position paper gives consideration to the epidemiological features of the disease and assesses the potential use of the vaccine for public health benefits...
April 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28370307/open-label-proof-of-concept-study-of-brexanolone-in-the-treatment-of-severe-postpartum-depression
#11
Stephen J Kanes, Helen Colquhoun, James Doherty, Shane Raines, Ethan Hoffmann, David R Rubinow, Samantha Meltzer-Brody
OBJECTIVE: Preclinical evidence indicates that rapid changes in levels of allopregnanolone, the predominant metabolite of progesterone, confer dramatic behavioral changes and may trigger postpartum depression (PPD) in some women. Considering the pathophysiology of PPD (i.e., triggered by reproductive steroids), the need for fast-acting, efficacious treatments and the negative consequences of untreated PPD, there is an increasing focus on developing PPD therapies. Brexanolone (USAN; formerly SAGE-547 Injection), a proprietary injectable allopregnanolone formulation, was evaluated as a treatment for severe PPD in a proof-of-concept, open-label study...
March 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28365727/curated-protein-information-in-the-saccharomyces-genome-database
#12
Sage T Hellerstedt, Robert S Nash, Shuai Weng, Kelley M Paskov, Edith D Wong, Kalpana Karra, Stacia R Engel, J Michael Cherry
Due to recent advancements in the production of experimental proteomic data, the Saccharomyces genome database (SGD; www.yeastgenome.org ) has been expanding our protein curation activities to make new data types available to our users. Because of broad interest in post-translational modifications (PTM) and their importance to protein function and regulation, we have recently started incorporating expertly curated PTM information on individual protein pages. Here we also present the inclusion of new abundance and protein half-life data obtained from high-throughput proteome studies...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28365719/outreach-and-online-training-services-at-the-saccharomyces-genome-database
#13
Kevin A MacPherson, Barry Starr, Edith D Wong, Kyla S Dalusag, Sage T Hellerstedt, Olivia W Lang, Robert S Nash, Marek S Skrzypek, Stacia R Engel, J Michael Cherry
The Saccharomyces Genome Database (SGD; www.yeastgenome.org ), the primary genetics and genomics resource for the budding yeast S. cerevisiae , provides free public access to expertly curated information about the yeast genome and its gene products. As the central hub for the yeast research community, SGD engages in a variety of social outreach efforts to inform our users about new developments, promote collaboration, increase public awareness of the importance of yeast to biomedical research, and facilitate scientific discovery...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28364147/sages-clinical-spotlight-review-intraoperative-cholangiography
#14
William W Hope, Robert Fanelli, Danielle S Walsh, Vimal K Narula, Ray Price, Dimitrios Stefanidis, William S Richardson
No abstract text is available yet for this article.
March 31, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28361450/the-sage-of-canberra-tony-mcmichael-on-climate-history-and-health
#15
Howard Frumkin
No abstract text is available yet for this article.
March 30, 2017: EcoHealth
https://www.readbyqxmd.com/read/28357958/the-essentials-of-nursing-leadership-taylor-ruth-and-webster-henderson-brian-the-essentials-of-nursing-leadership-216pp-%C3%A2-22-99-sage-publishing-9781412962025-1412962021-formula-see-text
#16
Joanna Copeman
All aspects of leadership are covered in this excellent book. The first part focuses on theory of leadership, and the second on the necessary skills, approaches and styles.
March 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28351259/law-and-ethics-in-nursing-and-healthcare-an-introduction-second-edition-avery-graham-law-and-ethics-in-nursing-and-healthcare-an-introduction-second-edition-392pp-%C3%A2-26-99-sage-9781412961745-1412961742-formula-see-text
#17
(no author information available yet)
This book aims to deliver key concepts of law and ethics in an easy-to-read style. In an area of healthcare that is fraught with rapid changes, challenges and misunderstandings, the author achieves this.
March 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28350723/reasons-for-interfacility-emergency-department-transfer-and-care-at-the-receiving-facility
#18
Joyce Li, Stephanie Pryor, Ben Choi, Chris A Rees, Mamata V Senthil, Nicholas Tsarouhas, Sage R Myers, Michael C Monuteaux, Richard G Bachur
OBJECTIVES: The aims of this study were to (1) assess the reasons for pediatric interfacility transfers as identified by transferring providers and review the emergency medical care delivered at the receiving facilities and (2) investigate the emergency department (ED) care among the subpopulation of patients discharged from the receiving facility. METHODS: We performed a multicenter, cross-sectional survey of ED medical providers transferring patients younger than 18 years to 1 of 4 US tertiary care pediatric hospitals with a subsequent medical record review at the receiving facility...
March 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28341256/the-ability-of-selected-plant-essential-oils-to-enhance-the-action-of-recommended-antibiotics-against-pathogenic-wound-bacteria
#19
Monika Sienkiewicz, Monika Łysakowska, Edward Kowalczyk, Grażyna Szymańska, Ewa Kochan, Jolanta Krukowska, Jurek Olszewski, Hanna Zielińska-Bliźniewska
The aim of this work was to characterize the ability of essential oils to support antibiotics against pathogenic bacteria in wounds. Gram-positive and Gram-negative bacteria obtained from wound infections were identified according to standard microbiological methods. Essential oils were analysed by GC-FID-MS. The susceptibility of bacteria to antibiotics, essential oils and their combination was assessed using the disc-diffusion method. The Minimal Inhibitory Concentration and Minimum Bactericidal Concentration of the essential oils were established by the micro-dilution broth method...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28333995/better-living-through-conifer-removal-a-demographic-analysis-of-sage-grouse-vital-rates
#20
John P Severson, Christian A Hagen, Jason D Tack, Jeremy D Maestas, David E Naugle, James T Forbes, Kerry P Reese
Sagebrush (Artemisia spp.) obligate wildlife species such as the imperiled greater sage-grouse (Centrocercus urophasianus) face numerous threats including altered ecosystem processes that have led to conifer expansion into shrub-steppe. Conifer removal is accelerating despite a lack of empirical evidence on grouse population response. Using a before-after-control-impact design at the landscape scale, we evaluated effects of conifer removal on two important demographic parameters, annual survival of females and nest survival, by monitoring 219 female sage-grouse and 225 nests in the northern Great Basin from 2010 to 2014...
2017: PloS One
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