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Aspirin exacerbated respiratory disease

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https://www.readbyqxmd.com/read/29040053/periostin-as-a-biomarker-for-nasal-polyps-in-chronic-rhinosinusitis
#1
Alice Z Maxfield, Lukas D Landegger, Christopher D Brook, Ashton E Lehmann, Adam P Campbell, Regan W Bergmark, Konstantina M Stankovic, Ralph Metson
Objective Periostin is an extracellular matrix protein that is elevated in the sinonasal tissues of patients with chronic rhinosinusitis (CRS). The purpose of this study was to determine whether serum periostin could serve as a molecular biomarker of nasal polyp burden in sinonasal disease. Study Design Prospective cohort study. Setting Academic medical center. Subjects and Methods Serum periostin levels were measured by ELISA on blood samples collected from patients undergoing sinus surgery for CRS (n = 71), further stratified by phenotype as defined by nasal polyps and asthma...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29035123/physiopathology-and-genetics-in-aspirin-exacerbated-respiratory-disease
#2
Gandhi F Pavón-Romero, Fernando Ramírez-Jiménez, Marco Alejandro Roldán-Alvarez, Luis M Terán, Ramcés Falfán-Valencia
INTRODUCTION: Aspirin-exacerbated respiratory disease (AERD) is a clinical entity characterized by hypersensitivity to aspirin leading to asthma and chronic rhinosinusitis with nasosinusal polyposis. The pathophysiology of the disease involves disruption at the level of arachidonic acid metabolism. Therefore, genetic association studies have been focused on the genes coding this pathway. As other mechanisms involved in the genesis of the disease were elucidated, the corresponding genes were also explored...
October 16, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28888846/diagnostic-accuracy-of-urinary-lte4-measurement-to-predict-aspirin-exacerbated-respiratory-disease-in-patients-with-asthma
#3
Grazyna Bochenek, Tomasz Stachura, Krystyna Szafraniec, Hanna Plutecka, Marek Sanak, Ewa Nizankowska-Mogilnicka, Krzysztof Sladek
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) are distinguished from patients with aspirin-tolerant asthma (ATA) by significantly higher baseline concentrations of urinary leukotriene E4 (uLTE4). However, an overlap between the individual values of the groups exists. OBJECTIVE: The objective of this study was to estimate the discriminative value of uLTE4 concentration in differentiating between patients with AERD and patients with ATA and evaluate the diagnostic accuracy of uLTE4 measurement alone and added to clinical parameters to predict AERD diagnosis in patients with asthma...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28863237/a-prospective-analysis-evaluating-tissue-biopsy-location-and-its-clinical-relevance-in-chronic-rhinosinusitis-with-nasal-polyps
#4
Ava R Weibman, Julia He Huang, Whitney W Stevens, Lydia A Suh, Caroline P E Price, Alcina K Lidder, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Atsushi Kato, Robert C Kern, Robert P Schleimer, Bruce K Tan
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high propensity for recurrence. Studies suggest that eosinophilia influences disease severity and surgical outcomes, but the selection of sinonasal site for measuring eosinophilia has not been examined. The aim of this study was to investigate how region-specific tissue eosinophilia affects radiographic severity, comorbidity prevalence, and polyp recurrence risk following sinus surgery. METHODS: Eosinophil cationic protein (ECP) levels in uncinate tissue (UT) and nasal polyp (NP) homogenates from 116 CRSwNP patients were measured using enzyme-linked immunosorbent assay (ELISA)...
September 1, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28859705/immunoglobulin-g4-sinusitis-in-association-with-aspirin-exacerbated-respiratory-disease
#5
Kirti Johal, Kevin Welch, Anju Peters
BACKGROUND: Immunoglobulin G4 (IgG4) related disease is a systemic inflammatory disease characterized by tumor-like tissue infiltration with IgG4 positive (IgG4+) plasma cells. Aspirin-exacerbated respiratory disease (AERD) is defined as asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to cyclooxygenase-1 inhibitors. OBJECTIVE: We described a case of a non-smoking 61-year-old male with prior NSAID sensitivity who presented with a 1-year history of left eye proptosis associated with chronic nasal symptoms, ultimately identified as concurrent AERD and IgG4 sinusitis...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28859704/an-update-on-the-epidemiology-of-aspirin-exacerbated-respiratory-disease
#6
Andrew A White
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade. METHODS: AERD warrants specific evaluation as an endotype of asthma and chronic sinus disease due to unique therapeutic opportunities. Currently, aspirin therapy is uniquely beneficial as an anti-inflammatory therapy in AERD, with multiple additional therapies currently in early to late clinical studies, which might also show exceptional benefit in AERD...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28852271/potential-biomarkers-for-nsaid-exacerbated-respiratory-disease
#7
REVIEW
Hanki Park, Youngwoo Choi, Chang-Gyu Jung, Hae-Sim Park
Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28743424/blood-eosinophil-to-basophil-ratio-in-patients-with-sinonasal-polyps-does-it-have-a-clinical-role
#8
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Francesco Cinetto, Luciano Giacomelli, Alessandro Martini, Gino Marioni
BACKGROUND: In a recent preliminary study, eosinophil and basophil counts were calculated in chronic rhinosinusitis with nasal polyps (CRSwNP) using conventional histologic and immunohistochemical methods. The tissue eosinophil-to-basophil ratio differed in the CRSwNP endotypes considered. OBJECTIVE: To compare the blood eosinophil-to-basophil ratio (bEBR) in a large series of patients with CRSwNP with that in a control group of consecutive rhinological patients with no evidence of nasal, paranasal, or systemic inflammatory disorders...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28737507/leukotrienes-and-sex-strange-bedfellows
#9
Lewis J Smith
Leukotrienes are proinflammatory lipid mediators that have been shown to be upregulated in several diseases, including asthma, aspirin-exacerbated respiratory disease (AERD), inflammatory bowel disease, and acute respiratory distress syndrome. Leukotrienes have been explored as therapeutic targets for these diseases and others; however, leukotriene inhibitors have had limited success in the clinic. There are noted differences in the incidence of leukotriene-mediated diseases in males and females, but sex as a factor in the response to leukotriene inhibitors has not been fully explored...
August 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28668243/effect-of-misoprostol-on-patients-with-aspirin-exacerbated-respiratory-disease-undergoing-aspirin-challenge-and-desensitization
#10
Kristen M Walters, Ronald A Simon, Katharine M Woessner, Nathan E Wineinger, Andrew A White
BACKGROUND: Prostaglandin E2 (PGE2) is an anti-inflammatory compound that inhibits 5-lipoxygenase activity. Diminished PGE2 regulation in aspirin-exacerbated respiratory disease (AERD) leads to respiratory reactions on cyclooxygenase 1 inhibition. In vitro studies have found that exogenous PGE2 stabilizes inflammatory mediator release. OBJECTIVE: To examine whether misoprostol (oral prostaglandin E1 analogue) use during aspirin challenge and desensitization might decrease the severity of aspirin-induced symptoms and make desensitization safer for patients with AERD...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28590311/aspirin-challenge-and-desensitization-how-when-and-why
#11
Gabriele Cortellini, Cristiano Caruso, Antonino Romano
PURPOSE OF REVIEW: To investigate the current approach to aspirin challenge (drug provocation) and/or desensitization in patients with histories of hypersensitivity reactions to it, particularly in those with cardiovascular diseases. RECENT FINDINGS: The literature indicates that patients with coronary artery disease (CAD), including those with an acute coronary syndrome, may safely undergo low-dose aspirin challenge and/or desensitization. Recently, flowcharts regarding challenge/desensitization procedures with aspirin in patients with CAD and histories of aspirin hypersensitivity reactions have become available...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28589859/integrative-information-theoretic-network-analysis-for-genome-wide-association-study-of-aspirin-exacerbated-respiratory-disease-in-korean-population
#12
Sehee Wang, Hyun-Hwan Jeong, Dokyoon Kim, Kyubum Wee, Hae-Sim Park, Seung-Hyun Kim, Kyung-Ah Sohn
BACKGROUND: Aspirin Exacerbated Respiratory Disease (AERD) is a chronic medical condition that encompasses asthma, nasal polyposis, and hypersensitivity to aspirin and other non-steroidal anti-inflammatory drugs. Several previous studies have shown that part of the genetic effects of the disease may be induced by the interaction of multiple genetic variants. However, heavy computational cost as well as the complexity of the underlying biological mechanism has prevented a thorough investigation of epistatic interactions and thus most previous studies have typically considered only a small number of genetic variants at a time...
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28583479/smoking-cessation-as-a-possible-risk-factor-for-the-development-of-aspirin-exacerbated-respiratory-disease-in-smokers
#13
Hiroaki Hayashi, Yuma Fukutomi, Chihiro Mitsui, Eiji Nakatani, Kentaro Watai, Yosuke Kamide, Kiyoshi Sekiya, Takahiro Tsuburai, Satoru Ito, Yoshinori Hasegawa, Masami Taniguchi
BACKGROUND: The pathogenesis of aspirin-exacerbated respiratory disease (AERD) is characterized by the low expression of cyclooxygenase-2 (COX-2) in airway epithelia, which decreases the production of prostaglandin E2 (PGE2). Conversely, cigarette smoke stimulates COX-2 expression in airway epithelia. Therefore, it was hypothesized that the development of AERD would be suppressed by elevated PGE2 levels in smokers, and smoking cessation might increase susceptibility to AERD. OBJECTIVE: The objective of this study was to evaluate the relationship between smoking and the risk of AERD development...
June 2, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28570221/nasal-ketorolac-challenge-using-acoustic-rhinometry-in-patients-with-aspirin-exacerbated-respiratory-disease
#14
J Quiralte-Castillo, M R Ávila-Castellano, S Cimbollek, P Benaixa, S Leguisamo, K Baynova, M Labella, J Quiralte
BACKGROUND AND OBJECTIVE: Safer and less time-consuming alternatives to single-blind placebo-controlled oral challenge (SBPCOC) have been sought for the diagnosis of aspirin-exacerbated respiratory disease (AERD). Nasal challenges with various nonsteroidal anti-inflammatory drugs and assessment methods have been developed. Objective: Our objective was to evaluate the utility and safety of nasal ketorolac challenge (NKC) using acoustic rhinometry in patients with suspected AERD. METHODS: The study population comprised 36 patients with suspected AERD...
June 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28550988/safety-and-outcomes-of-aspirin-desensitization-for-aspirin-exacerbated-respiratory-disease-a%C3%A2-single-center-study
#15
Jeremy Waldram, Kristen Walters, Ronald Simon, Katherine Woessner, Jill Waalen, Andrew White
BACKGROUND: Aspirin desensitization is an effective treatment option for aspirin-exacerbated respiratory disease. Aspirin desensitization protocol modifications have improved the safety and efficiency of this procedure, yet some providers remain reluctant to perform it. OBJECTIVE: The primary objective of this study was to evaluate the safety and outcomes of outpatient aspirin desensitization procedures. A secondary objective was to assess clinical characteristics that might predict reaction severity during aspirin desensitization...
May 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28516039/a-plane-screw-fixation-is-a-nidus-for-paecilomyces-sinusitis-in-a-patient-with-aspirin-exacerbated-respiratory-disease
#16
Anthony M Szema, Cyrus Jo
Titanium plane screw fixation of the frontal sinus is an approach used by otolaryngologists to obliterate this space in an attempt to reduce sinus infections. In this case, however, the titanium used became a nidus of infection which cultured the fungus Paecilomyces. The patient also had a hypersensitivity reaction to mold with positive skin tests and IgE, as well as eosinophilic esophagitis. Treatment entailed anti-fungals, anti-IgE, and fungal immunotherapy to multiple fungal antigens prevalent to the geographic region...
2017: IDCases
https://www.readbyqxmd.com/read/28499777/lack-of-efficacy-of-symptoms-and-medical-history-in-distinguishing-the-degree-of-eosinophilia-in-nasal-polyps
#17
John W Steinke, Anna R Smith, Delaney J Carpenter, James T Patrie, Spencer C Payne, Larry Borish
BACKGROUND: Distinguishing eosinophilic nasal polyps (NP) from noneosinophilic NP will impact prognosis and therapeutic responsiveness. OBJECTIVE: To investigate the ability of clinical history and biomarkers to distinguish these conditions. METHODS: A total of 74 consecutive patients undergoing surgery for NP were enrolled. Clinical presentations were evaluated using the 22-item sinonasal outcome test (SNOT-22). Biomarkers included absolute eosinophil count, IgE, and extent of tissue hyperplasia on sinus computed tomography scan...
May 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28489959/mood-disorders-in-adult-asthma-phenotypes
#18
Marina Labor, Slavica Labor, Iva Jurić, Vladimir Fijačko, Sanja Popović Grle, Davor Plavec
OBJECTIVE: Studies show high comorbidity of mood disorders in asthma. As asthma is a highly heterogeneous disease with different phenotypes it can be expected that there is a difference in this association with different asthma phenotypes. The aim of our cross-sectional study was to assess the association of specific asthma phenotypes with anxiety and/or depression and their impact on asthma control. METHODS: A cross-sectional study in 201 consecutive adult outpatients with asthma (≥18 years of age) was conducted...
May 10, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28457643/risk-of-obstructive-sleep-apnea-in-african-american-patients-with-chronic-rhinosinusitis
#19
Jessica W Hui, Jason Ong, James J Herdegen, Hajwa Kim, Christopher D Codispoti, Vahid Kalantari, Mary C Tobin, Robert P Schleimer, Pete S Batra, Phillip S LoSavio, Mahboobeh Mahdavinia
BACKGROUND: It is widely known that patients with chronic rhinosinusitis (CRS) commonly experience sleep disruption. Many of these patients have the associated diagnosis of obstructive sleep apnea (OSA). However, little is known about the risk factors for developing OSA in the CRS population. OBJECTIVE: To identify the risk factors for OSA in CRS to determine who should be screened for OSA among patients with CRS. METHODS: We evaluated a large cohort of patients with confirmed diagnostic criteria for CRS...
June 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28457528/disease-associations-with-isolated-elevations-of-each-of-the-four-igg-subclasses
#20
Sarah Engelhart, Robert J Glynn, Peter H Schur
PURPOSE: Immunoglobulin G4-related disease (IgG4-RD) is a relatively newly defined disease entity that refers to a group of immune-mediated disorders that have certain histopathologic, serologic, and clinical features in common. IgG4-RD is often associated with elevated serum IgG4. The discovery of IgG4-RD highlights the scarcity of literature examining elevations in other IgG subclasses and their potential associations to disease. In this retrospective chart review study, we aim to address that gap, by exploring disease associations in patients with isolated IgG subclass elevations...
March 30, 2017: Seminars in Arthritis and Rheumatism
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