Olena Koshyk, Carina A Dehner, Mari F C M van den Hout, Isabelle Vanden Bempt, Raf Sciot, Hsuan-Ying Huang, Abbas Agaimy, Nasir Ud Din, Natálie Klubíčková, Elaheh Mosaieby, Alena Skálová, Květoslava Michalová, Patrick Schöffski, Andre M Oliveira, Kevin C Halling, Sounak Gupta, John M Gross, Johanna W M Nin, Michal Michal, Andrew L Folpe, Kemal Kosemehmetoglu, Jorge Torres-Mora, Michael Michal
EWSR1::POU2AF3 (COLCA2) sarcomas are a recently identified group of undifferentiated round/spindle cell neoplasms with a predilection for the head and neck region. Herein, we report our experience with 8 cases, occurring in 5 men and 3 women (age range, 37-74 years; median, 60 years). Tumors involved the head/neck (4 cases), and one each the thigh, thoracic wall, fibula, and lung. Seven patients received multimodal therapy; 1 patient was treated only with surgery. Clinical follow-up (8 patients; range, 4-122 months; median, 32 months) showed 5 patients with metastases (often multifocal, with a latency ranging from 7 to 119 months), and 3 of them also with local recurrence...
December 2023: Modern Pathology