keyword
https://read.qxmd.com/read/38030212/histological-assessment-of-synovial-sarcoma-before-and-after-tcr-t-cell-therapy-and-cryoablation-a-case-report
#21
JOURNAL ARTICLE
Kunihiro Asanuma, Mikiya Ishihara, Tomoki Nakamura, Katsunori Uchida, Tomohito Hagi, Shinichi Kageyama, Hiroshi Shiku, Akihiro Sudo
BACKGROUND/AIM: Cancer/testis antigens (CTAs) are well-known molecular targets with expression restricted to testicular germ cells and malignant tumors. T-cell receptor (TCR)-engineered T-cell (TCR-T) therapy against CTAs in patients with sarcoma has shown substantial progress, but resistance to TCR-T therapy remains a critical problem. In this report, we present a case of synovial sarcoma treated with TCR-T therapy targeting the New York-esophageal squamous cell carcinoma (NY-ESO)-1 protein...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030190/indolent-multinodular-synovial-sarcoma-of-peripheral-nerves-mimicking-schwannoma-a-case-report-and-literature-review
#22
REVIEW
Tomonori Kawasaki, Jiro Ichikawa, Hiroki Imada, Satoshi Kanno, Kojiro Onohara, Yasuo Yazawa, Rikito Tatsuno, Takahiro Jyubashi, Tomoaki Torigoe
BACKGROUND/AIM: Most cases of synovial sarcoma (SS) are aggressive and large-sized; only few show indolent behavior, having a small size. Nerves are rare sites of SS occurrence. An atypical case of SS can lead to its misdiagnosis as a benign tumor and delay its treatment. CASE REPORT: Here, we report a case of primary SS of indolent multinodular synovial sarcoma of peripheral nerves. Considering the clinical and imaging findings at the first visit, we suspected a benign tumor and continued careful follow-up...
December 2023: Anticancer Research
https://read.qxmd.com/read/38028103/synovial-sarcoma-of-the-maxilla-a-challenging-diagnostic-case-report-and-literature-review
#23
Nasrollah Saghravanian, Amin Rahpeyma, Mahsa Ghorbani, Pooya Saeedi
Synovial sarcoma, a malignant mesenchymal tumor, is primarily associated with the extremities. Nevertheless, its appearance within the head and neck region, particularly in the maxillary area, is remarkably rare. This rarity underscores the significance of each case in unraveling the complexities of its behavior and management strategies. The core focus of this research is a detailed case report involving a 6-year-old female patient who presented with a conspicuous swelling in the left posterior maxilla. Subsequent incisional biopsy led to microscopic identification of malignant spindle cell proliferation, marked by dysplastic changes, and abundant mitoses...
November 2023: Clinical Case Reports
https://read.qxmd.com/read/37966703/small-gastric-synovial-sarcoma-diagnosed-and-treatment-by-laparoscopic-endoscopic-cooperative-surgery-a-case-report
#24
JOURNAL ARTICLE
Yuya Sato, Shinji Morita, Akihiko Yoshida, Shigetaka Yoshinaga, Toshiro Nishida
We report a case of small gastric synovial sarcoma (SS) finally diagnosed after laparoscopic-endoscopic cooperative surgery (LECS). A 50 year-old male underwent medical examination for a chief complaint of epigastric pain. Endoscopic examination showed a 20 mm submucosal tumor (SMT) located in the anterior wall which extended to the lesser curvature of the middle stomach. The biopsy tissue did not yield a definitive diagnosis. During 6 months of follow-up for this lesion suspected to be an inflammatory tumor, neither the shape nor the size of the tumor changed...
November 15, 2023: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/37958467/the-role-of-macrophages-in-sarcoma-tumor-microenvironment-and-treatment
#25
REVIEW
Agnieszka E Zając, Anna M Czarnecka, Piotr Rutkowski
Sarcomas are a heterogeneous group of malignant mesenchymal tumors, including soft tissue and bone sarcomas. Macrophages in the tumor microenvironment, involved in immunosuppression and leading to tumor development, are called tumor-associated macrophages (TAMs). TAMs are very important in modulating the microenvironment of sarcomas by expressing specific markers and secreting factors that influence immune and tumor cells. They are involved in many signaling pathways, such as p-STAT3/p-Erk1/2, PI3K/Akt, JAK/MAPK, and JAK/STAT3...
November 5, 2023: Cancers
https://read.qxmd.com/read/37920695/treatment-at-relapse-for-synovial-sarcoma-of-children-adolescents-and-young-adults-from-the-state-of-art-to-future-clinical-perspectives
#26
REVIEW
Andrea Ferrari, Pablo Berlanga, Susanne Andrea Gatz, Reineke A Schoot, Max M van Noesel, Shushan Hovsepyan, Stefano Chiaravalli, Luca Bergamaschi, Veronique Minard-Colin, Nadege Corradini, Rita Alaggio, Patrizia Gasparini, Bernadette Brennan, Michela Casanova, Sandro Pasquali, Daniel Orbach
While the overall prognosis is generally quite satisfactory in children, adolescents and young adults with localised synovial sarcoma at first diagnosis, the outcome remains poor for patients after relapse. Conversely to the front-line standardised treatment options, patients with relapse generally have an individualised approach and to date, there is still a lack of consensus regarding standard treatment approaches. Studies on relapsed synovial sarcoma were able to identify some prognostic variables that influence post-relapse survival, in order to plan risk-adapted salvage protocols...
2023: Cancer Management and Research
https://read.qxmd.com/read/37900845/epstein-barr-virus-positive-lymphoproliferative-disorder-following-lymphodepletion-for-mage-a4-adoptive-cellular-therapy-in-a-patient-with-synovial-sarcoma-a-case-report
#27
Maggie Zhou, Ghazal Jawed, Kristen N Ganjoo
Lymphoproliferative disorder (LPD) associated with viral reactivation is a known risk of immunocompromised patients. With development of novel cellular therapies utilizing lymphodepletion regimens in advanced cancer, the risk of LPDs should be a consideration. Here, we report a case of a 61-year-old treated male with history of metastatic synovial sarcoma and multiple treatment lines treated with cell therapy (lymphodepleting chemotherapy and afami-cel, formerly ADP-A2M4, T-cell treatment) on clinical study that developed Epstein Barr virus-positive LPD...
2023: Case Reports in Oncology
https://read.qxmd.com/read/37900632/primary-gastric-synovial-sarcoma-in-a-young-male-a-rare-case-report-and-review-of-literature
#28
Sachin S Kadam, Tejaswini Kadam
We are reporting a rare case of primary gastric synovial sarcoma in a young male. Synovial sarcoma of the stomach is a very rare tumor. The common involved sites of occurrence of synovial sarcomas are upper and lower extremities. In the English literature, only 47 cases of primary synovial sarcoma of stomach have been reported. Spindle-shaped tumor cells are the basic content of synovial sarcomas with varying degrees of epithelial differentiation. The basic classification of synovial sarcoma depends on the histological pattern and the degree of differentiation and it is classified as monophasic, biphasic, and poorly differentiated...
September 2023: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/37899499/utility-of-immunohistochemistry-with-antibodies-to-ss18-ssx-chimeric-proteins-and-c-terminus-of-ssx-protein-for-synovial-sarcoma-differential-diagnosis
#29
JOURNAL ARTICLE
Jerzy Lasota, Małgorzata Chłopek, Maciej Kaczorowski, Klubíčková Natálie, Janusz Ryś, Janusz Kopczyński, Oksana Sulaieva, Michael Michal, Anna Kruczak, Agnieszka Harazin-Lechowska, Magdalena Szczepaniak, Olena Koshyk, Agnieszka Hałoń, Piotr Czapiewski, Zied Abdullaev, Artur Kowalik, Kenneth D Aldape, Michal Michal, Markku Miettinen
Synovial sarcoma is a relatively common soft tissue tumor characterized by highly specific t(X;18)(p11;q11) translocation resulting in the fusion of SS18 with members of SSX gene family. Typically, detection of SS18 locus rearrangement by fluorescence in situ hybridization or SS18 :: SSX fusion transcripts confirms the diagnosis. More recently, immunohistochemistry (IHC) for SS18-SSX chimeric protein (E9X9V) and C-terminus of SSX (E5A2C) showed high specificity and sensitivity for synovial sarcoma. This study screened a cohort of >1000 soft tissue and melanocytic tumors using IHC and E9X9V and E5A2C antibodies...
January 1, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/37899317/-primary-synovial-sarcoma-of-lung-a-clinicopathological-analysis-of-12-cases
#30
JOURNAL ARTICLE
X W Zhang, J G Wei, J P Sun, Z G Xu, Q Cheng, L Zhang, L F Kong
Objective: To investigate the clinicopathological features, immunophenotype, molecular features and differential diagnosis of primary synovial sarcoma of the lung (PSSL). Methods: Twelve cases of PSSL were collected at Henan Provincial People's Hospital, during May 2010 and April 2021, and their clinicopathological parameters were summarized. SS18-SSX, H3K27Me3, and SOX2 were added to the original immunomarkers to evaluate their diagnostic value for PSSL. Results: The age of 12 patients when diagnosed ranged from 32 to 75 years (mean of 50 years)...
November 8, 2023: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/37879825/synovial-sarcoma-with-ossification-and-calcification-with-ss18-immunochemical-expression-and-rearrangement-by-fluorescent-in-situ-hybridization
#31
Luis A Acosta-Calderón, César Lara-Torres, Leonardo S Lino-Silva, Claudia H Caro-Sánchez, Mayra E Jiménez-De Los Santos, Hugo R Domínguez-Malagón
Synovial sarcoma is a soft tissue tumor of uncertain origin. Generally, it is a monophasic spindle cell neoplasm that can have glandular-like structures. Ossification and presence of calcification is a rare phenomenon with only a few reported cases. We present the case of a young male with a synovial sarcoma of the right foot. Histology revealed prominent deposits of tumoral osteoid and coarse calcifications. The diagnosis was confirmed by the expression of SS18 by immunohistochemistry and the demonstration of the rearrangement of the SS18 gene by fluorescent in situ hybridization...
2023: Revista Española de Patología
https://read.qxmd.com/read/37864652/biphasic-synovial-sarcoma-with-myoepithelial-features-a-distinctive-variant-with-a-predilection-for-the-foot
#32
JOURNAL ARTICLE
Shahd S Almohsen, Anthony M Griffin, Brendan C Dickson, Elizabeth G Demicco
Synovial sarcoma (SS) is a tumor known for its classic monophasic spindle cell or biphasic morphology. However, it exhibits a wide range of histologic variations, leading to diagnostic challenges. Here, we present four cases of molecularly confirmed, biphasic SS originating in the feet and displaying myoepithelial differentiation. The patients were two men and two women with an age range from 19 to 71 years (mean, 45 years). Each tumor showed foci with conventional spindle cell morphology. The epithelial components included areas with nests and cords of epithelioid cells set within a hyalinized and sclerotic stroma...
October 21, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37809216/unveiling-the-mystery-a-case-report-on-oropharyngeal-synovial-sarcoma
#33
Soraia Gonçalves, Catarina Soares, Rita Ribeiro, Sílvia Sousa
Synovial sarcoma, originating from mesenchymal cells, represents a rare and aggressive sarcoma subtype. This case report describes a rare occurrence of synovial sarcoma in the soft palate, with only a few cases described in the literature. A 38-year-old male presented with a painless mass on the soft palate, which raised suspicion of an abscess and emphasized the importance of considering malignancy in persistent or progressive soft tissue masses, even in atypical anatomical locations. The diagnostic workup, including imaging modalities such as maxillofacial computed tomography (CT) scan, magnetic resonance imaging (MRI), and positron emission tomography-fluorodeoxyglucose (PET-FDG) scan, played a crucial role in confirming the diagnosis and assessing disease extension...
September 2023: Curēus
https://read.qxmd.com/read/37792433/safety-and-efficacy-of-ny-eso-1-antigen-specific-t-cell-receptor-gene-transduced-t-lymphocytes-in-patients-with-synovial-sarcoma-a-phase-i-ii-clinical-trial
#34
JOURNAL ARTICLE
Akira Kawai, Mikiya Ishihara, Tomoki Nakamura, Shigehisa Kitano, Shintaro Iwata, Kohichi Takada, Makoto Emori, Koji Kato, Makoto Endo, Yoshihiro Matsumoto, Shigeki Kakunaga, Eiichi Sato, Yoshihiro Miyahara, Kunihiko Morino, Shinya Tanaka, Shuichi Takahashi, Fujio Matsuo, Akihiko Matsumine, Shinichi Kageyama, Takafumi Ueda
PURPOSE: To determine, for patients with advanced or recurrent synovial sarcoma (SS) not suitable for surgical resection and resistant to anthracycline, the safety and efficacy of the infusion of autologous T lymphocytes expressing NY-ESO-1 antigen-specific T-cell receptor (TCR) gene and siRNA to inhibit the expression of endogenous TCR (product code: TBI-1301). PATIENTS AND METHODS: Eligible Japanese patients (HLA-A*02:01 or *02:06, NY-ESO-1-positive tumor expression) received cyclophosphamide 750 mg/m2 on days -3 and -2 (induction period) followed by a single dose of 5×109 (±30%) TBI-1301 cells as a divided infusion on days 0 and 1 (treatment period)...
December 15, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37783308/reconstruction-of-the-proximal-radius-with-3d-printed-personalized-prosthesis-after-tumor-resection-case-series
#35
JOURNAL ARTICLE
Zhuangzhuang Li, Minxun Lu, Yuqi Zhang, Taojun Gong, Jie Wang, Yi Luo, Yong Zhou, Qing Chang, Jingqi Lin, Li Min, Chongqi Tu
BACKGROUND: Giant cell tumor of bone (GCTB) (Campanacci III) or malignant tumors extend to the epiphyseal region, and intra-articular resection of the proximal radius is often needed. In the present study, we present the patients who underwent reconstruction of the proximal radius with 3D-printed personalized prosthesis after tumor resection, aiming to describe the prosthesis design and surgical technique and evaluate the clinical outcomes of this method. METHODS: Between November 2018 and January 2021, nine patients received radial hemiarthroplasty with 3D-printed personalized prostheses after tumor resection...
September 30, 2023: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/37752544/long-intergenic-non-coding-rna-dio3os-promotes-osteosarcoma-metastasis-via-activation-of-the-tgf-%C3%AE-signaling-pathway-a-potential-diagnostic-and-immunotherapeutic-target-for-osteosarcoma
#36
JOURNAL ARTICLE
Jinghong Yuan, Jingyu Jia, Tianlong Wu, Zhi Du, Qi Chen, Jian Zhang, Zhiwen Wu, Zhao Yuan, Xiaokun Zhao, Jiahao Liu, Jia Guo, Xigao Cheng
BACKGROUND: The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify that DIO3OS can be used as a potential diagnostic biomarker and immunotherapeutic target. METHODS: The expression matrix data and clinical information were obtained from XENA platform of UCSC and GEO database as the test cohorts. The external validation cohort was collected from our hospital. Bioinformatics analysis was used to annotate the biological function of DIO3OS...
September 26, 2023: Cancer Cell International
https://read.qxmd.com/read/37742928/ewsr1-pou2af3-colca2-sarcoma-an-aggressive-polyphenotypic-sarcoma-with-a-head-and-neck-predilection
#37
JOURNAL ARTICLE
Olena Koshyk, Carina A Dehner, Mari F C M van den Hout, Isabelle Vanden Bempt, Raf Sciot, Hsuan-Ying Huang, Abbas Agaimy, Nasir Ud Din, Natálie Klubíčková, Elaheh Mosaieby, Alena Skálová, Květoslava Michalová, Patrick Schöffski, Andre M Oliveira, Kevin C Halling, Sounak Gupta, John M Gross, Johanna W M Nin, Michal Michal, Andrew L Folpe, Kemal Kosemehmetoglu, Jorge Torres-Mora, Michael Michal
EWSR1::POU2AF3 (COLCA2) sarcomas are a recently identified group of undifferentiated round/spindle cell neoplasms with a predilection for the head and neck region. Herein, we report our experience with 8 cases, occurring in 5 men and 3 women (age range, 37-74 years; median, 60 years). Tumors involved the head/neck (4 cases), and one each the thigh, thoracic wall, fibula, and lung. Seven patients received multimodal therapy; 1 patient was treated only with surgery. Clinical follow-up (8 patients; range, 4-122 months; median, 32 months) showed 5 patients with metastases (often multifocal, with a latency ranging from 7 to 119 months), and 3 of them also with local recurrence...
December 2023: Modern Pathology
https://read.qxmd.com/read/37735617/aberrant-gene-activation-in-synovial-sarcoma-relies-on-ssx-specificity-and-increased-prc1-1-stability
#38
JOURNAL ARTICLE
Nezha S Benabdallah, Vineet Dalal, R Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K F Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O Nielsen, T Michael Underhill, Ana Banito
The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C terminus, which can be exploited by fusion to transcriptional regulators beyond SS18. Accordingly, SS18-SSX recruitment occurs in a manner that is independent of the core components and catalytic activity of BAF. Alternative SSX fusions are also recruited to H2AK119ub1-rich chromatin and reproduce the expression signatures of SS18-SSX by engaging with transcriptional activators...
September 21, 2023: Nature Structural & Molecular Biology
https://read.qxmd.com/read/37701646/spindle-cell-thymoma-and-its-histological-mimickers
#39
REVIEW
Annikka Weissferdt
Spindle cell thymomas are the most common spindle cell neoplasms of the anterior mediastinum. These tumors belong to the group of thymic epithelial neoplasms and are known for their wide histomorphologic spectrum. This histological heterogeneity is the reason why unequivocal diagnosis can be challenging, especially when dealing with small biopsy material. Conversely, less conventional patterns of the tumor may also pose significant diagnostic problems in resected material and the differential diagnosis often includes other spindle cell neoplasms that are known to arise in the mediastinal cavity...
2023: Mediastinum
https://read.qxmd.com/read/37701639/giant-middle-mediastinal-lesions-when-tumor-size-correlates-with-mesenchymal-origin-a-retrospective-single-center-analysis
#40
JOURNAL ARTICLE
Stéphane Collaud, Theresa Stork, Hafsa Kaman, Sebastian Bauer, Christoph Pöttgen, Hans-Ulrich Schildhaus, Bastian Schmack, Clemens Aigner
BACKGROUND: The International Thymic Malignancy Interest Group (ITMIG) proposed an internationally accepted division of the mediastinum into three compartments based on computed tomography (CT): anterior (prevascular), middle (visceral) and posterior (paravertebral) compartment. There is no generally accepted definition for the term "giant" when applied to middle mediastinal lesions. We defined the term "giant" and described our surgical experience in treating patients with giant lesions of the middle mediastinum...
2023: Mediastinum
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