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Pediatric cancer survivors

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https://www.readbyqxmd.com/read/29740904/falling-through-the-cracks-a-thematic-evaluation-of-unmet-needs-of-adult-survivors-of-childhood-cancers
#1
Jennifer White, Joanne Park, K Brooke Russell, K A Reynolds, A Madani, Linda E Carlson, Janine Giese-Davis
BACKGROUND: The population of adult survivors of childhood cancers (ASCCs) is growing, resulting in unique long-term challenges. This study explored experiences of perceived unmet ASCC survivorship needs. METHODS: We invited ASCCs to complete surveys sent through the cancer registry. Four open-ended questions allowed participants to write in comments. We analyzed responses to these open-ended questions thematically, employing a process of constant comparison. RESULTS: Our sample included 94 ASCCs who completed open-ended questions (61 female; aged 20-78 years, mean age=34...
May 8, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29734385/growth-patterns-of-survivors-of-retinoblastoma-treated-with-ophthalmic-artery-chemosurgery
#2
Sruti S Akella, Jasmine H Francis, Andrea Knezevic, Irina Ostrovnaya, Y Pierre Gobin, Danielle Friedman, Edith Guarini, Lindsey Eibeler, Federica Catalanotti, David H Abramson
Although studies from pediatric cancers (largely acute lymphoblastic leukemia) have shown that patients undergoing systemic chemotherapy may experience decreased growth velocity during the treatment phase, no such data exist for retinoblastoma patients treated with systemic chemotherapy or ophthalmic artery chemosurgery (OAC). The purpose of this study is to report growth patterns of our retinoblastoma (Rb) population who were treated with OAC in a retrospective, single center (Memorial Sloan Kettering Cancer Center) review of 341 patients treated between 2006 and 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29730064/risk-of-radiation-vasculopathy-and-stroke-in-pediatric-patients-treated-with-proton-therapy-for-brain-and-skull-base-tumors
#3
Matthew D Hall, Julie A Bradley, Ronny L Rotondo, Ricardo Hanel, Chetan Shah, Christopher G Morris, Philipp R Aldana, Daniel J Indelicato
PURPOSE: To estimate the rate of and identify risk factors for vasculopathy after proton therapy in pediatric patients with central nervous system and skull base tumors. METHODS AND MATERIALS: Between 2006 and 2015, 644 pediatric patients with central nervous system and skull base tumors were treated with proton therapy at a single institution. The 3 most common histologies were craniopharyngioma (n = 135), ependymoma (n = 135), and low-grade glioma (n = 131)...
March 29, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29713910/employment-status-and-termination-among-survivors-of-pediatric-brain-tumors-a-cross-sectional-survey
#4
Iori Sato, Akiko Higuchi, Takaaki Yanagisawa, Shiho Murayama, Toshihiro Kumabe, Kazuhiko Sugiyama, Akitake Mukasa, Nobuhito Saito, Yutaka Sawamura, Mizuhiko Terasaki, Soichiro Shibui, Jun Takahashi, Ryo Nishikawa, Yasushi Ishida, Kiyoko Kamibeppu
BACKGROUND: Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS: A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) and their attending physicians from nine institutions in Japan. We compared category and time-series histories for participants' first-time employment using national census information...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29700907/psychosexual-development-and-satisfaction-with-timing-of-developmental-milestones-among-adult-survivors-of-childhood-cancer
#5
Vicky Lehmann, Madelaine C Keim, Amanda C Ferrante, Randal S Olshefski, Cynthia A Gerhardt
OBJECTIVE: To extend the limited research on psychosexual development among childhood cancer survivors, by not only focusing on the prevalence and age of milestone attainment, but also survivors- attitudes toward the timing of reaching such milestones. METHODS: Adult survivors of childhood cancer (N=90; Mage =29.8, SD=5.2), recruited from a U.S. pediatric institution, completed online surveys indicating whether they had reached five milestones of psychosexual development (i...
April 27, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#6
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29672608/psychosocial-interventions-for-rehabilitation-and-reintegration-into-daily-life-of-pediatric-cancer-survivors-and-their-families-a-systematic-review
#7
Mona Leandra Peikert, Laura Inhestern, Corinna Bergelt
BACKGROUND: The survival rate of childhood cancer patients increased over the past decades. However, even after successful treatment the transition back to normalcy is often a major challenge for the whole family. Therefore, this study aims to provide an overview of psychosocial interventions for childhood cancer survivors and their families in the first years after the end of cancer treatment. METHODS: We conducted a systematic review following the PRISMA Checklist (Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PROSPERO registration number: CRD42017059782)...
2018: PloS One
https://www.readbyqxmd.com/read/29672191/knowledge-and-beliefs-about-oncofertility-and-associations-with-quality-of-life-among-adolescent-and-young-adult-survivors-of-pediatric-cancer
#8
Andrea C Johnson, Darren Mays, Kathryn Rehberg, Aziza Shad, Kenneth P Tercyak
PURPOSE: Adolescent and young adult (AYA) cancer survivors experience fertility and childrearing challenges in adulthood, but there is limited evidence on awareness, beliefs, and concerns about oncofertility in this population, needs for supportive resources, and associations with quality of life (QoL). METHODS: Participants were 69 AYAs aged 12-25 who were diagnosed with cancer at age 18 years or younger and ≥1 year cancer free, recruited from childhood cancer clinical records and support organizations...
April 19, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29671249/importance-ratings-on-patient-reported-outcome-items-for-survivorship-care-comparison-between-pediatric-cancer-survivors-parents-and-clinicians
#9
Conor M Jones, Justin N Baker, Rachel M Keesey, Ruth J Eliason, Jennifer Q Lanctot, Jennifer L Clegg, Belinda N Mandrell, Kirsten K Ness, Kevin R Krull, Deokumar Srivastava, Christopher B Forrest, Melissa M Hudson, Leslie L Robison, I-Chan Huang
PURPOSE: To compare importance ratings of patient-reported outcomes (PROs) items from the viewpoints of childhood cancer survivors, parents, and clinicians for further developing short-forms to use in survivorship care. METHODS: 101 cancer survivors, 101 their parents, and 36 clinicians were recruited from St. Jude Children's Research Hospital. Participants were asked to select eight items that they deemed useful for clinical decision making from each of the four Patient-Reported Outcomes Measurement Information System Pediatric item banks...
April 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29667769/targeting-the-phosphatidylinositol-3-kinase-akt-mechanistic-target-of-rapamycin-signaling-pathway-in-b-lineage-acute-lymphoblastic-leukemia-an-update
#10
REVIEW
Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri
Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15-20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo- and radiation therapy, including secondary malignancies, are a growing problem for leukemia survivors. Targeted therapy holds promising perspectives for cancer treatment as it may be more effective and have fewer side effects than conventional therapies. The phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway is a key regulatory cascade which controls proliferation, survival and drug-resistance of cancer cells, and it is frequently upregulated in the different subtypes of B-ALL, where it plays important roles in the pathophysiology, maintenance and progression of the disease...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29660436/in-vitro-study-of-doxorubicin-induced-oxidative-stress-in-spermatogonia-and-immature-sertoli-cells
#11
Amélie R Tremblay, Geraldine Delbes
Pediatric chemotherapy treatments can impair long-term male fertility. Unfortunately, no fertility preservation solution is available for pre-pubertal boys. Studies suggest that doxorubicin, used against pediatric cancers, induces oxidative stress in the testis. However, the targeted testicular cell types remain unknown. The goal of this study was to determine whether doxorubicin can induce oxidative stress in rat spermatogonia (GC-6Spg) and immature Sertoli (Ser-W3) cell lines, and to assess their protection by antioxidants...
April 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29658062/mental-health-insurance-access-and-utilization-among-childhood-cancer-survivors-a-report-from-the-childhood-cancer-survivor-study
#12
Giselle K Perez, Anne C Kirchhoff, Christopher Recklitis, Kevin R Krull, Karen A Kuhlthau, Paul C Nathan, Julia Rabin, Gregory T Armstrong, Wendy Leisenring, Leslie L Robison, Elyse R Park
PURPOSE: To describe and compare the prevalence of mental health access, preference, and use among pediatric cancer survivors and their siblings. To identify factors associated with mental health access and use among survivors. METHODS: Six hundred ninety-eight survivors in the Childhood Cancer Survivor Study (median age = 39.4; median years from diagnosis = 30.8) and 210 siblings (median age = 40.4) were surveyed. Outcomes included having mental health insurance coverage, delaying care due to cost, perceived value of mental health benefits, and visiting a mental health provider in the past year...
April 15, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29652554/impact-of-attention-on-social-functioning-in-pediatric-medulloblastoma-survivors
#13
Alice Ann Holland, Beth Colaluca, Laurie Bailey, Peter L Stavinoha
BACKGROUND: Parent-reported attention problems have been associated with social functioning in a broad sample of pediatric cancer survivors. OBJECTIVE: The present study focused on a more homogeneous sample (pediatric medulloblastoma survivors), with the novel inclusion of self-reported attention ratings. PARTICIPANTS/METHODS: Thirty-three pediatric medulloblastoma survivors, ages 7-18 years, completed a brief IQ measure and self-report of attentional and social functioning...
April 13, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29629696/non-pharmacological-interventions-for-pediatric-cancer-patients-a-comparative-review-and-emerging-needs-in-india
#14
Sujata Satapathy, Tanuja Kaushal, Sameer Bakhshi, Rakesh Kumar Chadda
CONTEXT: Evidence-based research on psycho-oncology in last three decades lays emphasis upon the critical role of psychological services for better illness adjustment, improved quality of life, reduced distress and cognitive problems among the rapidly increasing pediatric cancer population. JUSTIFICATION: This review aims to summarize the evidence-based psychological interventions in childhood cancer over the two decades and addresses the wide gap that existed between intervention studies worldwide and India, thus highlighting the need for research and appropriate services...
March 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29607375/new-trends-and-recent-care-approaches-in-pediatric-oncology-nursing
#15
REVIEW
Ebru Kilicarslan Toruner, Naime Altay
Increased incidence of children diagnosed with cancer and survivors was an impact on changes in pediatric hemato-oncology nursing care. In this review article, it is aimed to investigate the new trends and recent care approaches in pediatric oncology nursing. The recent care topics were common in the literature as family-centered care, technology-based care, program development, primary care of child, health-care provider, survivors and home care, and nonpharmacological care. All of the topics contribute to perform evidence-based care for health promotion and well-being in pediatric hemato-oncology nursing...
April 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29600747/the-effectiveness-of-a-hospital-based-school-liaison-program-a-comparative-study-of-parental-perception-of-school-supports-for-children-with-pediatric-cancer-and-neurofibromatosis-type-1
#16
Lisa Northman, Marybeth Morris, Caitlyn Loucas, Sarah Ross, Anna C Muriel, Dongjing Guo, Wendy B London, Peter Manley, Nicole J Ullrich
Childhood survivors of central nervous system (CNS) cancers (defined as cancers whose diagnosis or treatment affect the CNS) are at increased risk for educational related difficulties, as are children affected by neurofibromatosis type 1. This study evaluated the effectiveness of and satisfaction with a model of psychoeducation, consultation, and advocacy provided by a School Liaison Program (SLP) for families and schools of children with CNS-involved cancers compared with a control group of parents of children with a diagnosis of neurofibromatosis type 1 who did not receive school-based services...
March 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29587881/teddi-radiotherapy-delivery-in-deep-inspiration-for-pediatric-patients-a-nopho-feasibility-study
#17
Anni Young Lundgaard, Lisa Lyngsie Hjalgrim, Laura Ann Rechner, Mirjana Josipovic, Morten Joergensen, Marianne Camille Aznar, Anne Kill Berthelsen, Lise Borgwardt, Christoffer Johansen, Annika Loft, Akmal Safwat, Leila Vaalavirta, Lena Specht, Maja Vestmoe Maraldo
BACKGROUND: Radiotherapy (RT) delivered in deep inspiration breath-hold (DIBH) is a simple technique, in which changes in patient anatomy can significantly reduce the irradiation of the organs at risk (OARs) surrounding the treatment target. DIBH is routinely used in the treatment of some adult patients to diminish the risk of late effects; however, no formalized studies have addressed the potential benefit of DIBH in children. METHODS/DESIGN: TEDDI is a multicenter, non-randomized, feasibility study...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29575995/large-vessel-arteriopathy-after-cranial-radiation-therapy-in-pediatric-brain-tumor-survivors
#18
Matthew Nordstrom, Erin Felton, Katherine Sear, Benita Tamrazi, Joseph Torkildson, Karen Gauvain, Daphne A Haas-Kogan, Josephine Chen, Benedict Del Buono, Anuradha Banerjee, David Samuel, David Saloner, Bing Tian, Erika Roddy, Christopher Hess, Heather Fullerton, Sabine Mueller
Among childhood cancer survivors, increased stroke risk after cranial radiation therapy may be caused by radiation-induced arteriopathy, but limited data exist to support this hypothesis. Herein, we assess the timing and presence of cerebral arteriopathy identified by magnetic resonance angiography (MRA) after cranial radiation therapy in childhood brain tumor survivors. In a cohort of 115 pediatric brain tumor survivors, we performed chart abstraction and prospective annual follow-up to assess the presence of large vessel cerebral arteriopathy by MRA...
April 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29575028/ultrasound-and-the-evaluation-of-pediatric-thyroid-malignancy-current-recommendations-for-diagnosis-and-follow-up
#19
REVIEW
Sarah Ogle, Alexa Merz, Ralitza Parina, Mahmoud Alsayed, Mira Milas
Ultrasound (US) plays a critical role in the evaluation, treatment, screening, and surveillance of thyroid malignancy in pediatric patients. This review aims to summarize recent advances in this topic. Improvements in imaging technology have amplified the advantage of US and US-guided fine-needle aspiration biopsy for thyroid nodule evaluation, cancer diagnosis, and surgical planning. Ultrasound has a definitive screening role for early cancer detection in high-risk patients, including those with a history of radiation exposure from childhood treatments, environmental radiation disasters, or hereditary/familial cancer syndromes...
March 25, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29574250/a-pre-clinical-assessment-of-the-pan-erbb-inhibitor-dacomitinib-in-pediatric-and-adult-brain-tumors
#20
Raelene Endersby, Jacqueline Whitehouse, Hilary Hii, Sameer A Greenall, Terrance G Johns, Nicholas G Gottardo
Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. The survival for patients with glioblastoma remains dismal. While the cure rate for medulloblastoma exceeds 70%, this figure has stagnated over the past few decades and survivors still contend with significant long-term debilitating side effects. The prognosis for pineoblastoma is age-dependent, with little chance of a cure for children younger than three years. More effective molecularly targeted strategies are urgently required to treat these cancers...
March 22, 2018: Neoplasia: An International Journal for Oncology Research
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