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https://www.readbyqxmd.com/read/29574586/precision-medicine-in-chronic-rhinosinusitis-with-nasal-polyps
#1
REVIEW
Klementina Avdeeva, Wytske Fokkens
PURPOSE OF REVIEW: Chronic rhinosinusitis is a disease with high prevalence, significant impact on health-related quality of life (HRQoL) and it is associated with substantial healthcare and productivity costs. We face an urgent need to improve the level of disease control and achieve higher patient satisfaction and disease prevention. Precision medicine is increasingly recognized as the way forward in optimal patient care. The combination of personalized care, prevention of disease, prediction of success of treatment, and participation of the patient in the elaboration of the treatment plan is expected to guarantee the best possible therapeutic approach for individuals suffering from a chronic disabling condition...
March 24, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29550078/nasal-polyposis-pathophysiology-endotype-and-phenotype-open-issues
#2
REVIEW
Giuseppe Brescia, Claudia Zanotti, Daniela Parrino, Umberto Barion, Gino Marioni
PURPOSE: Endotyping chronic rhinosinusitis with nasal polyps (CRSwNP) poses a challenge for rhinologists nowadays. Phenotyping CRSwNP proved inappropriate as an approach to their classification because of their common clinical features. Endotyping, being based on the pathogenic mechanism, provides a precise picture more appropriate for use in clinical practice. Patients' treatment and follow-up can thus be tailored to cope with the degree of aggressiveness of a specific CRSwNP endotype...
March 7, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29535967/primary-sinonasal-mucosal-melanoma-simulated-as-cystic-lesions-a-case-report
#3
Sung-Ho Shin, Hyun Seok, Seong-Gon Kim, Seong-Doo Hong
Sinonasal mucosal melanoma (SNMM) in the maxillary sinus is a rare disease condition. Compared to oral mucosal melanoma, SNMM has a bulky, exophytic, and polypoid appearance, is weakly pigmented, and associated with unspecific symptoms. Due to these features, SNMM in the maxillary sinus has been misdiagnosed as nasal polyps and chronic sinusitis. In this case report, we described SNMM occurring in the right maxillary sinus simulated as a cystic or benign lesion. Cortical bone thinning and expansion were observed around the mass...
February 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29501242/comorbidity-disease-burden-and-mortality-across-age-groups-in-a-swedish-primary-care-asthma-population-an-epidemiological-register-study-pacehr
#4
Karin Lisspers, Christer Janson, Kjell Larsson, Gunnar Johansson, Gunilla Telg, Marcus Thuresson, Björn Ställberg
BACKGROUND: Asthma is often associated with other diseases. To identify and manage comorbidities is important, as these conditions may increase the disease burden. OBJECTIVE: To describe the prevalence of comorbidities, disease burden and mortality across age groups in a large Swedish primary care real-life asthma population. METHODS: Observational cohort study of asthma patients, all ages, identified from electronic medical records by ICD-10-CM code, data from 36 primary care centers...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29432969/age-related-prevalence-of-chronic-rhinosinusitis-and-nasal-polyps-and-their-relationships-with-asthma-onset
#5
Ha-Kyeong Won, Young-Chan Kim, Min-Gyu Kang, Han-Ki Park, Seung-Eun Lee, Min-Hye Kim, Min-Suk Yang, Yoon-Seok Chang, Sang-Heon Cho, Woo-Jung Song
BACKGROUND: Chronic rhinosinusitis (CRS) is a major disease condition with high morbidity, and may influence lower airway disease status in adults. However, its associations with adult asthma onset and activity have not been examined in detail in a general adult population. OBJECTIVE: To investigate the relationships between CRS with nasal polyps and asthma characteristics. METHODS: A cross-sectional dataset from 17,506 adult participants (age≥18 years) in the Korean National Health and Nutrition Examination Survey 2010-2012 was analyzed...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29395935/factors-reducing-omalizumab-response-in-severe-asthma
#6
B Sposato, M Scalese, M Milanese, S Masieri, C Cavaliere, M Latorre, N Scichilone, A Matucci, A Vultaggio, A Ricci, A Cresti, P Santus, A Perrella, P L Paggiaro
BACKGROUND: Despite adding Omalizumab to conventional therapy, several severe asthmatics still show poor disease control. We investigated the factors that may affect a reduced Omalizumab response in a large population of severe asthmatics. METHODS: 340 patients were retrospectively evaluated. FEV1 %, FVC%, Asthma Control Test (ACT), fractional exhaled nitric oxide (FENO), possible step-downs/step-ups of concomitant therapies, exacerbations, disease control levels, ICS doses and SABA use, observed at the end of treatment, were considered as a response to Omalizumab...
January 29, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29362708/upper-airway-involvement-in-bronchiectasis-is-marked-by-early-onset-and-allergic-features
#7
Michal Shteinberg, Najwan Nassrallah, Jenny Jrbashyan, Nechama Uri, Nili Stein, Yochai Adir
The association of bronchiectasis with chronic rhinosinusitis (CRS) has been reported. However, apart from primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), predisposing conditions have not been established. We aimed to define clinical and laboratory features that differentiate patients with bronchiectasis with upper airway symptoms (UASs) and without PCD from patients without UASs. We reviewed charts of adults with bronchiectasis, excluding CF and PCD. UASs were defined as nasal discharge most days of the year, sinusitis or nasal polyps...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#8
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29279055/chronic-rhinosinusitis-with-nasal-polyps-in-the-elderly-assessing-current-evidence
#9
Gino Marioni, Claudia Zanotti, Giuseppe Brescia
BACKGROUND: The recently reported prevalence of chronic rhinosinusitis (CRS) among people >60 years old was 4.7%, with CRS emerging as the sixth most common chronic condition in the elderly. There is still a dearth of studies that focused on older patients, however, regarding the characteristics of CRS with nasal polyps (CRSwNP). OBJECTIVE: The emerging role of CRSwNP endotyping to enable a tailored medical approach (for elderly patients also) was investigated...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29204922/usefulness-of-our-proposed-olfactory-scoring-system-during-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis
#10
Ken Okazaki, Kenzo Tsuzuki, Kengo Hashimoto, Hiroki Nishikawa, Hironori Takebayashi, Hideki Oka, Yusuke Kojima, Yoriko Yukitatsu, Yasuo Mishiro, Masafumi Sakagami
INTRODUCTION: The primary aim of the current study was to examine the usefulness of our proposed olfactory scoring system in chronic rhinosinusitis (CRS) patients with olfactory disorders (n = 213) receiving endoscopic sinus surgery (ESS). MATERIALS AND METHODS: Analyzed patients were divided into two groups: an eosinophilic CRS (ECRS) group (n = 153); and a non-ECRS group (n = 60). The T&T recognition threshold test was used to evaluate olfaction at baseline and at 3 and 12 months after ESS...
February 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29055085/current-use-of-baseline-medical-treatment-in-chronic-rhinosinusitis-data-from-the-national-chronic-rhinosinusitis-epidemiology-study-cres
#11
C Philpott, S Erskine, R Smith, C Hopkins, N Kara, A Farboud, M Salam, A Robertson, R Almeyda, B N Kumar, S Anari, J Ray, R Cathcart, S Carrie, S Ahmed, H Khalil, A Clark, M Thomas
OBJECTIVES: According to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. DESIGN AND SETTING: Case-control study in a secondary care setting...
April 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28990844/impact-of-nasal-conditions-on-chronic-otitis-media-a-cross-sectional-study-in-koreans
#12
Kyung Wook Heo, Min Jae Kim, Jun Ho Lee
OBJECTIVES: We evaluated the relationship between pathological nasal conditions and pathological middle ear conditions on a large-scale epidemiological basis, conducted as a cross-sectional study at the population level using Korean National Health and Nutrition Examination Survey (KNHANES) data. STUDY DESIGN: A cross-sectional study. METHODS: In a retrospective cohort study, we analyzed data from the KNHANES (2008-2012), which used a stratified, multi-stage, probability-cluster sampling method in a rolling sampling survey of South Korean citizens...
February 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28706720/endotype-driven-treatment-in-chronic-upper-airway-diseases
#13
REVIEW
Glynnis De Greve, Peter W Hellings, Wytske J Fokkens, Benoit Pugin, Brecht Steelant, Sven F Seys
Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS have been described based on symptom severity and duration, atopy status, level of control, comorbidities and presence or absence of nasal polyps in CRS. The underlying pathophysiological mechanisms are diverse, with different, and sometimes overlapping, endotypes being recognized...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28624844/the-effect-of-endoscopic-sinus-surgery-on-quality-of-life-and-absenteeism-in-patients-with-chronic-rhinosinuitis-a-multi-centre-study
#14
P Sahlstrand-Johnson, C Hopkins, B Ohlsson, M Ahlner-Elmqvist
BACKGROUND: Chronic rhinosinusitis with and without nasal polyps (CRSw/sNP) are common conditions decreasing health-related quality of life (HRQOL). Individual symptoms capable of predicting outcome after endoscopic sinus surgery (ESS) are poorly defined, and the indirect costs of CRS is rarely reported in Europe. METHODOLOGY: Patients with CRSw/sNP admitted for ESS were prospectively enrolled. Patients completed the 22 Sinonasal Outcome Test (SNOT-22), the short-form 36-item questionnaire (SF-36), a Visual Analogue Scale (VAS) and reported CRS-related absenteeism pre- and post-operatively...
September 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28499777/lack-of-efficacy-of-symptoms-and-medical-history-in-distinguishing-the-degree-of-eosinophilia-in-nasal-polyps
#15
John W Steinke, Anna R Smith, Delaney J Carpenter, James T Patrie, Spencer C Payne, Larry Borish
BACKGROUND: Distinguishing eosinophilic nasal polyps (NP) from noneosinophilic NP will impact prognosis and therapeutic responsiveness. OBJECTIVE: To investigate the ability of clinical history and biomarkers to distinguish these conditions. METHODS: A total of 74 consecutive patients undergoing surgery for NP were enrolled. Clinical presentations were evaluated using the 22-item sinonasal outcome test (SNOT-22). Biomarkers included absolute eosinophil count, IgE, and extent of tissue hyperplasia on sinus computed tomography scan...
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28498517/health-utility-reporting-in-chronic-rhinosinusitis-patients
#16
J Bewick, S Morris, C Hopkins, S Erskine, C M Philpott
OBJECTIVES: Direct comparison of different diseases allows clinicians and researchers to place the burden of symptoms and impact on quality of life of each condition in context. Generic health-related quality-of-life assessment tools allow such analysis, and limited data are available for British patients with chronic rhinosinusitis. DESIGN: As part of a larger feasibility study, patients underwent baseline assessment using the SNOT-22, SF-12 and EQ-5D-5L tools...
February 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28340867/comparative-prevalence-of-co-morbidities-in-smoking-and-non-smoking-asthma-patients-with-incomplete-reversibility-of-airway-obstruction-non-smoking-asthma-patients-with-complete-reversibility-of-airway-obstruction-and-copd-patients
#17
Myriam Nadeau, Marie-Ève Boulay, Joanne Milot, Johane Lepage, Lara Bilodeau, François Maltais, Louis-Philippe Boulet
BACKGROUND: Asthma with incomplete reversibility of airway obstruction (IRAO) may often be associated to smoking-induced changes. Nevertheless, a high proportion of patients showing IRAO have never smoked. These patients with IRAO often share features of patients with chronic obstructive pulmonary disease (COPD). Although IRAO is still a poorly defined condition, it has been associated with a higher morbidity and mortality than asthma with complete reversibility of airway obstruction (CRAO) or even COPD alone...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28272838/mortality-risk-in-patients-with-chronic-rhinosinusitis-and-its-association-to-asthma
#18
Jeremiah A Alt, Andrew J Thomas, Karen Curtin, Jathine Wong, Luke Rudmik, Richard R Orlandi
BACKGROUND: Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory condition, with significant effects on morbidity and quality of life. Given that other chronic inflammatory conditions have been associated with increased mortality risk, we sought to evaluate the relationship between mortality and CRS including the influence of asthma. Our objective was to determine if CRS, with or without asthma, is associated with altered risk of mortality. METHODS: Using a statewide population database, we retrospectively identified 27,005 patients diagnosed with CRS between 1996 and 2012, and 134,440 unaffected controls matched 5:1 on birth year and sex...
June 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28216437/extracellular-eosinophilic-traps-in-association-with-staphylococcus-aureus-at-the-site-of-epithelial-barrier-defects-in-patients-with-severe-airway-inflammation
#19
Elien Gevaert, Nan Zhang, Olga Krysko, Feng Lan, Gabriële Holtappels, Natalie De Ruyck, Hans Nauwynck, Shida Yousefi, Hans-Uwe Simon, Claus Bachert
BACKGROUND: Chronic rhinosinusitis with nasal polyps is characterized by TH2-biased eosinophilic inflammation. Eosinophils have been shown to generate so-called extracellular eosinophilic traps (EETs) under similar pathologic conditions. OBJECTIVE: Our aim was to investigate a possible link between EET formation and the presence of Staphylococcus aureus, an organism frequently colonizing the upper airways, at the human mucosal site of the disease. METHODS: Tissue slides were investigated for the presence of EETs and S aureus by using immunofluorescent staining and the PNA-Fish assay, respectively...
June 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28050473/evaluation-of-sinonasal-diseases-by-computed-tomography
#20
Rashmi Kandukuri, Suresh Phatak
INTRODUCTION: Computed Tomography (CT) plays an important diagnostic role in patients with sinonasal diseases and determines the treatment. The CT images clearly show fine structural architecture of bony anatomy thereby determining various anatomical variation, extent of disease and characterization of various inflammatory, benign and malignant sinonasal diseases. AIM: To evaluate sensitivity and specificity of CT in diagnosis of sinonasal diseases and to characterise the benign and malignant lesions with the help of various CT parameters...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
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