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Nasal polyps associated conditions

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https://www.readbyqxmd.com/read/27879191/replacement-of-sfc-dpi-with-sfc-mdi-exhaled-through-the-nose-improved-eosinophilic-chronic-rhinosinusitis-with-bronchial-asthma%C3%A2
#1
Yoshiki Kobayashi, Mikiya Asako, Takahisa Yamamoto, Hirotaka Yasuba, Koichi Tomoda, Akira Kanda
OBJECTIVE: Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is a refractory disease closely associated with bronchial asthma. We recently reported on the efficacy of ultra-fine particle inhaled corticosteroids (ICS) (hydrofluoroalkane-134a-beclomethasone dipropionate: HFA-BDP) exhalation through the nose (ETN) treatment for mild-to-moderate asthmatics with ECRS. However, the effect of HFA-BDP ETN was found to be transient in some cases with severe ECRS and asthma, requiring treatment with higher-dose ICS and long-acting β2-agonists (LABA)...
November 23, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27466854/topical-steroids
#2
Gretchen M Oakley, Richard J Harvey
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition with heterogeneous pathophysiology. A cornerstone of the management of this condition is the use of anti-inflammatory agents. Corticosteroids are very effective and the most commonly used, but other drugs with immunodulatory activity such as anti-IL5, doxycycline (Th2), and macrolides (anti-neutrophilic/IL8) have been shown to have efficacy. Although systemic corticosteroids have shown benefit in managing this condition, the frequency of use often required in this condition is associated with significant adverse effects...
2016: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27268094/role-of-atopy-in-chronic-rhinosinusitis-with-nasal-polyps-does-an-atopic-condition-affect-the-severity-and-recurrence-of-disease
#3
Q C Li, K J Cheng, F Wang, S H Zhou
BACKGROUND: The role of atopy in chronic rhinosinusitis is unclear: it is particularly controversial in chronic rhinosinusitis with nasal polyps. METHODS: A prospective study of 210 patients with chronic rhinosinusitis with nasal polyps was performed. Patient demographics, visual analogue scale scores, Lund-Kennedy endoscopy scores, Lund-Mackay computed tomography scores, serum total immunoglobulin E levels, serum eosinophil cationic protein (ECP) levels and Phadiatop test findings were analysed...
July 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27213662/-polypous-rhinosinusitis-in-the-children
#4
REVIEW
E P Karpova, M P Emel'yanova, D A Tulupov
We present an overview of the modern literature concerningpolypous rhinosinusitis (PRS) in the children. The information thus derived is compared with the available results of the clinical investigations involving the adults patients with this pathology. Allergic diseases and mucoviscidosis appear to be the pathological conditions most likely leading to the development of polyps in the nasal cavity. The patients suffering from rhinosinusitis associated with the disorders of arachidonic acid metabolismare very rarely encountered in the pediatric practice unlike those among the adult population...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27184027/occupational-and-environmental-risk-factors-for-chronic-rhinosinusitis-in-china-a-multicentre-cross-sectional-study
#5
Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P Z Li, Geng Xu, Jianbo Shi, Qing-Ling Fu
BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS. METHODS: Data were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP(3)OS) document...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27143164/cytokine-profile-of-nasal-and-middle-ear-polyps-in-a-patient-with-woakes-syndrome-and-eosinophilic-otitis-media
#6
Marie De Loof, Els De Leenheer, Gabriële Holtappels, Claus Bachert
Woakes' syndrome is characterised by severe recurrent nasal polyps in early childhood with broadening of the nose, nasal dyscrinia, frontal sinus aplasia and bronchiectasis. Eosinophilic otitis media (EOM) is an intractable condition that can cause gradual or sudden deterioration of hearing and is associated with comorbid asthma. For these reasons, both diseases must be recognised and treated appropriately. We present a case of a 20-year-old man with Woakes' syndrome complicated by EOM, with polyps in both middle ears; this condition has so far not been described as an entity of eosinophilic disease in the literature...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27115214/short-course-oral-steroids-as-an-adjunct-therapy-for-chronic-rhinosinusitis
#7
REVIEW
Karen Head, Lee Yee Chong, Claire Hopkins, Carl Philpott, Anne G M Schilder, Martin J Burton
BACKGROUND: This review is one of a suite of six Cochrane reviews looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is a common condition involving inflammation of the lining of the nose and paranasal sinuses. It is characterised by nasal blockage and nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Oral corticosteroids are used to control the inflammatory response and improve symptoms...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27113482/systemic-and-topical-antibiotics-for-chronic-rhinosinusitis
#8
REVIEW
Karen Head, Lee Yee Chong, Patorn Piromchai, Claire Hopkins, Carl Philpott, Anne G M Schilder, Martin J Burton
BACKGROUND: This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Systemic and topical antibiotics are used with the aim of eliminating infection in the short term (and some to reduce inflammation in the long term), in order to normalise nasal mucus and improve symptoms...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27113367/short-course-oral-steroids-alone-for-chronic-rhinosinusitis
#9
REVIEW
Karen Head, Lee Yee Chong, Claire Hopkins, Carl Philpott, Martin J Burton, Anne G M Schilder
BACKGROUND: This review is one of a suite of six Cochrane reviews looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is a common condition involving inflammation of the lining of the nose and paranasal sinuses. It is characterised by nasal blockage and nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Oral corticosteroids are used to control the inflammatory response and improve symptoms...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27080204/diagnostic-utility-of-urinary-lte4-in-asthma-allergic-rhinitis-chronic-rhinosinusitis-nasal-polyps-and-aspirin-sensitivity
#10
Rohit Divekar, John Hagan, Matthew Rank, Miguel Park, Gerald Volcheck, Erin O'Brien, Jeffrey Meeusen, Hirohito Kita, Joseph Butterfield
BACKGROUND: Urinary leukotriene E4 (LTE4) is a well-validated marker of the cysteinyl leukotriene pathway, and LTE4 elevation has been described in conditions such as asthma, aspirin sensitivity, and chronic rhinosinusitis (CRS). There have been a number of reports investigating the role of spot urine LTE4 to predict aspirin sensitivity; however, variability in urinary LTE4 may affect the accuracy of this approach. OBJECTIVE: Here, we explored the utility of 24-hour urinary LTE4 in 5 clinical diagnoses of allergic rhinitis, asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), CRS without nasal polyps, and aspirin sensitivity...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26987817/prognostic-factors-for-recurrence-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-with-nasal-polyps
#11
Tsuguhisa Nakayama, Daiya Asaka, Hiroaki Kanaya, Akihito Kuboki, Shin-Ichi Haruna
OBJECTIVE: In this study, we aimed to clarify the prognostic factors affecting the ethmoid condition during a long-term follow-up after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: Thirty-six patients with CRSwNP underwent surgery from December 2008 to February 2012. All surgeries were performed by one surgeon, and all patients were followed up for at least 2 years postoperatively. We investigated the association of postoperative endoscopic findings with clinical parameters, mucosal eosinophil count and mRNA expression of CCL11, IL-5, and IFN-gamma in nasal polyps...
December 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/26926305/impact-of-1607-1g-2g-mmp1-gene-polymorphism-on-the-morbidity-and-clinical-course-of-chronic-rhinosinusitis-with-nasal-polyps
#12
Paweł Molga, Wojciech Fendler, Maciej Borowiec, Wioletta Pietruszewska
UNLABELLED: Polyps within the nose and nasal sinuses are symptoms of both local conditions such as chronic bacterial or fungal rhinosinusitis, and systemic diseases such as cystic fibrosis, hypogammaglobulinemia, NSAID hypersensitivity syndrome, bronchial asthma as well as Kartagener's syndrome, Young's syndrome, Churg-Strauss' syndrome and Woakes' syndrome. The pathomechanism responsible for formation of nasal polyps remains a matter of dispute as well as the subject of numerous studies...
February 29, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/26746618/adenoid-hypertrophy-and-chronic-rhinosinusitis-helicobacter-pylori-on-antral-lavages-adenoid-tissue-and-salival-inmunoglobuline-a-on-paediatric-patients
#13
Eleazar E Graterón Cedeño, Diana Ortiz-Princz, Sinay A Ceballos Figueredo, María Eugenia Cavazza Porro
OBJECTIVE: To determine Helicobacter pylori presence on antral lavages, adenoids and salival inmunoglobuline A on paediatric patients with chronic rhinosinusitis without nasal polyps (CRSsNP) and adenoid hypertrophy. METHODS: Adenoid tissue, liquid obtained from antral lavages and saliva from 28 children diagnosed with CRSsNP, from the paediatric otorhinolaryngology practice of "Dr. Domingo Luciani" Hospital was taken and processed by means of polymerase chain reaction (PCR) using cagA, vacA and babA primers, also anatomopathological examination using Giemsa stain of the adenoids, determination of salivary specific secretory inmunoglobuline A (sIgA), socio-economic condition using the Graffar scale and associated gastrointestinal symptoms were assessed...
January 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/26654193/chronic-rhinosinusitis-pathogenesis
#14
REVIEW
Whitney W Stevens, Robert J Lee, Robert P Schleimer, Noam A Cohen
There are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided into 2 major subgroups based on whether nasal polyps are present or absent. Unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS...
December 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26370180/fibroblast-levels-are-increased-in-chronic-rhinosinusitis-with-nasal-polyps-and-are-associated-with-worse-subjective-disease-severity
#15
William W Carroll, Brendan P O'Connell, Rodney J Schlosser, David A Gudis, Tom T Karnezis, Lauren A Lawrence, Zachary M Soler, Jennifer K Mulligan
BACKGROUND: Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association between fibroblasts and disease severity. METHODS: Patients undergoing endoscopic sinus surgery (ESS) for CRS were prospectively enrolled from January 2011 to December 2014...
February 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/26332371/five-year-risk-of-incident-disease-following-a-diagnosis-of-chronic-rhinosinusitis
#16
A G Hirsch, X S Yan, A S Sundaresan, B K Tan, R P Schleimer, R C Kern, T L Kennedy, J S Greene, B S Schwartz
BACKGROUND: Chronic rhinosinusitis (CRS) has a broad range of comorbidities. Due to a lack of longitudinal studies, it is not known whether these comorbidities cause CRS, are promoted by CRS, or share a systemic disease process with CRS. OBJECTIVE: The objective of this study was to determine the risk of incident disease within 5 years after a new diagnosis of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). METHODS: We conducted a case-control study nested within the longitudinal cohort of primary care patients in the Geisinger Clinic using electronic health record data...
December 2015: Allergy
https://www.readbyqxmd.com/read/26325561/medical-therapies-for-adult-chronic-sinusitis-a-systematic-review
#17
REVIEW
Luke Rudmik, Zachary M Soler
IMPORTANCE: Chronic sinusitis is a common inflammatory condition defined by persistent symptomatic inflammation of the sinonasal cavities lasting longer than 3 months. It accounts for 1% to 2% of total physician encounters and is associated with large health care expenditures. Appropriate use of medical therapies for chronic sinusitis is necessary to optimize patient quality of life (QOL) and daily functioning and minimize the risk of acute inflammatory exacerbations. OBJECTIVE: To summarize the highest-quality evidence on medical therapies for adult chronic sinusitis and provide an evidence-based approach to assist in optimizing patient care...
September 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26314815/chronic-rhinosinusitis-management-beyond-intranasal-steroids-and-saline-solution-irrigations
#18
REVIEW
Newton Li, Anju T Peters
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease with clinical manifestations that are influenced by the presence or absence of nasal polyposis. Understanding of the current and future treatment modalities for CRS is essential in preventing exacerbation and morbidity associated with this chronic condition. OBJECTIVE: The aim of this article is to review the evidence behind current medical therapies and potential new treatments for CRS. METHODS: Scientific literature regarding intranasal and systemic antibiotics, intranasal systemic corticosteroids, and monoclonal antibodies as interventions for CRS with and without nasal polyps was reviewed...
September 2015: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/26122502/chronic-rhinosinusitis-and-the-coagulation-system
#19
REVIEW
Dong Young Kim, Seong H Cho, Tetsuji Takabayashi, Robert P Schleimer
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an etiologic role in many diseases, such as asthma and other inflammatory conditions. While studies on the relationship between asthma and dysregulated coagulation have been reported, the role of the coagulation system in the pathogenesis of CRS has only been considered following recent reports...
September 2015: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/26075169/allergic-rhinitis-an-overview
#20
Jitendra Varshney, Himanshu Varshney
Allergic rhinitis is an inflammatory disorder of the nasal mucosa induced by allergen exposure triggering IgE-mediated inflammation. Clinically, it is characterized by four major symptoms-rhinorrhea, sneezing, nasal itching, and nasal congestion. It can also be associated with co-morbid conditions as Asthma, Atopic Dermatitis & Nasal polyps. Around 20-30 % of the Indian population suffers from allergic rhinitis and that 15 % develop asthma. The diagnosis & treatment of allergic rhinitis should follow ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines while of asthma should follow the GINA (Global Initiative for Asthma) guidelines...
June 2015: Indian Journal of Otolaryngology and Head and Neck Surgery
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