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https://www.readbyqxmd.com/read/28453906/oral-treponeme-major-surface-protein-sequence-diversity-and-distributions-within-periodontal-niches
#1
Meng You, Yuki Chan, Donnabella C Lacap-Bugler, Yong-Biao Huo, Wenling Gao, W Keung Leung, Rory M Watt
Treponema denticola and other species (phylotypes) of oral spirochetes are widely-considered to play important etiological roles in periodontitis and other oral infections. The major surface protein (Msp) of T. denticola is directly implicated in several pathological mechanisms. Here, we have analyzed msp sequence diversity across 68 strains of oral phylogroup 1 and 2 treponemes; including reference strains of T. denticola, Treponema putidum, Treponema medium, 'Treponema vincentii', and 'Treponema sinensis'...
April 28, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28453689/periodontal-disease-edentulism-and-pancreatic-cancer-a-meta-analysis
#2
P Maisonneuve, S Amar, A B Lowenfels
Background: Periodontal disease (PD), now our commonest infectious disorder leads to tooth loss, and has been linked to various systemic diseases, including various types of cancer. The aim of this study is to provide a systematic review and a meta-analysis of the relationship between PD, edentulism, and pancreatic cancer (PC). Patients and methods: From an initial review of 327 references we selected eight studies concerning periodontitis or edentulism with sufficient quantitative information to allow us to examine the risk of PC...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453484/can-better-management-of-periodontal-disease-delay-the-onset-and-progression-of-alzheimer-s-disease
#3
Alice Harding, Sarita Robinson, St John Crean, Sim K Singhrao
A risk factor relationship exists between periodontal disease and Alzheimer's disease (AD) via tooth loss, and improved memory following dental intervention. This links the microbial contribution from indigenous oral periodontal pathogens to the manifestation of chronic conditions, such as AD. Here, we use Porphyromonas gingivalis infection to illustrate its effect on mental health. P. gingivalis infection, in its primary sub-gingival niche, can cause polymicrobial synergy and dysbiosis. Dysbiosis describes the residency of select commensals from the oral cavity following co-aggregation around the dominant keystone pathogen, such as P...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28449041/periodontal-disease-tooth-loss-and-cancer-risk
#4
Dominique S Michaud, Zhuxuan Fu, Jian Shi, Mei Chung
Periodontal disease, which includes gingivitis and periodontitis, is highly prevalent in adults and disease severity increases with age. The relationship between periodontal disease and oral cancer has been examined for several decades, but there is increasing interest in the link between periodontal disease and overall cancer risk, with systemic inflammation serving as the main focus for biological plausibility. Numerous case-control studies have addressed the role of oral health in head and neck cancer, and several cohort studies have examined associations with other types of cancers over the past decade...
April 25, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28449029/a-genome-wide-association-study-identifies-nucleotide-variants-at-siglec5-and-defa1a3-as-risk-loci-for-periodontitis
#5
Matthias Munz, Christina Willenborg, Gesa M Richter, Yvonne Jockel-Schneider, Christian Graetz, Ingmar Staufenbiel, Jürgen Wellmann, Klaus Berger, Bastian Krone, Per Hoffmann, Nathalie van der Velde, André G Uitterlinden, Lisette C P G M de Groot, Amr Sawalha, Haner Direskeneli, Güher Saruhan-Direskeneli, Esra Guzeldemir-Akcakanat, Gencay Keceli, Matthias Laudes, Barbara Noack, Alexander Teumer, Birte Holtfreter, Thomas Kocher, Peter Eickholz, Jörg Meyle, Christof Doerfer, Corinna Bruckmann, Wolfgang Lieb, Andre Franke, Stefan Schreiber, Rahime M Nohutcu, Jeanette Erdmann, Bruno G Loos, Soeren Jepsen, Henrik Dommisch, Arne S Schaefer
Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls)...
April 25, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28447734/high-glucose-promotes-the-osteogenic-differentiation-capability-of-human-periodontal-ligament-fibroblasts
#6
Sujiwan Seubbuk, Hathaitip Sritanaudomchai, Julalux Kasetsuwan, Rudee Surarit
Periodontal ligament fibroblasts (PDLFs) are important cells, which are involved in maintaining tooth integrity. Diabetes has been found to be associated with periodontal disease in a bidirectional manner. The aim of the present study was to investigate the stemness properties of human PDLFs (HPDLFs) in high glucose conditions. HPDLFs were analyzed for their osteogenic differentiation capacity by inducing the cells with osteogenic medium in various glucose concentrations. The gene expression was then examined using reverse transcription‑quantitative polymerase chain reaction analysis, and examinations of alkaline phosphatase activity and nodule formation were performed...
March 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28446907/regulation-and-molecular-basis-of-environmental-muropeptide-uptake-and-utilization-in-fastidious-oral-anaerobe-tannerella-forsythia
#7
Angela Ruscitto, Kiyonobu Honma, Vamsee M Veeramachineni, Kiyoshi Nishikawa, Graham P Stafford, Ashu Sharma
Tannerella forsythia is a Gram-negative oral anaerobe associated with periodontitis. This bacterium is auxotrophic for the peptidoglycan amino sugar N-acetylmuramic (MurNAc) and likely relies on scavenging peptidoglycan fragments (muropeptides) released by cohabiting bacteria during their cell wall recycling. Many Gram-negative bacteria utilize an inner membrane permease, AmpG, to transport peptidoglycan fragments into their cytoplasm. In the T. forsythia genome, the Tanf_08365 ORF has been identified as a homolog of AmpG permease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28440743/targeting-underlying-biologic-mechanisms-in-selecting-adjunctive-therapies-to-improve-periodontal-treatment-in-smokers-a-commentary
#8
Maria L Geisinger, Nicolaas C Geurs, Dorothy Ogdon, Michael S Reddy
Despite well-established evidence that cigarette smoking is the largest modifiable risk factor for periodontal disease and has many deleterious health effects, the treatment of periodontal disease in smokers remains a challenge of periodontal therapy. A recent meta-analysis revealed that the adjunctive use of local delivery of antimicrobials, but not systemic antibiotic usage, with nonsurgical periodontal therapy resulted in an improvement in clinical periodontal parameters. Further evaluation of the current literature reveals that host modulation therapy may also result in a clinical benefit in smokers...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28440740/biomarkers-and-bacteria-around-implants-and-natural-teeth-in-the-same-individuals
#9
Önder Gürlek, Pınar Gümüş, Christopher J Nile, David F Lappin, Nurcan Buduneli
AIM: This cross-sectional study assessed cytokine levels in peri-implant crevicular fluid (PICF)/ gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. MATERIAL AND METHODS: Samples from 97 implants/teeth (58 implants: 19 healthy, 20 mucositis, 19 peri-implantitis; 39 natural teeth: 19 healthy, 12 gingivitis, 8 periodontitis) in 15 systemically healthy patients were investigated by immunoassay, real-time PCR...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28439904/adaptation-and-validation-of-the-oral-health-literacy-instrument-for-the-chilean-population
#10
Ricardo A Cartes-Velásquez, Luis Luengo Machuca
OBJECTIVE: To report the adaptation and cultural validation of the Oral Health Literacy Instrument (OHLI) for the adult Chilean population attending public and university health services. STUDY DESIGN: The original OHLI in English was translated to Spanish and back-translated, then a preliminary version was obtained following review by four experts. A pilot study was carried out in 30 patients, who were asked to assess their understanding of the questionnaire. The following variables were included: sociodemographic factors (sex, age, average monthly income, education and marital status); oral health (history of caries, periodontal disease and oral hygiene); oral health-related quality of life; health literacy; oral health literacy; and psychometric properties (internal consistency, temporal stability, convergent validity and predictive validity)...
April 24, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28439581/lower-educational-level-is-a-risk-factor-for-tooth-loss-analysis-of-a-swiss-population-krebs-project
#11
Fabiola-Regina Rodriguez, Nadine Paganoni, Roland Weiger, Clemens Walter
PURPOSE: To analyse risk factors for tooth loss in women and men seeking treatment at the University of Basel, Switzerland. MATERIALS AND METHODS: Records of patients from the pool of patients at the department were consecutively screened between January 2009 and October 2011. Gender, smoking habits, education, profession, general health status and dental variables were recorded. Tooth loss was assessed on full-mouth periapical radiographs. Gender-nested logistic regression models were applied for statistical analysis...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28438978/peptoanaerobacter-stomatis-primes-human-neutrophils-and-induces-granule-exocytosis
#12
E Jimenez Flores, S Tian, M Sizova, S S Epstein, R J Lamont, S M Uriarte
Peptoanaerobacter stomatis is a newly appreciated taxon associated with periodontal diseases; however, little is known about the organism's pathogenic potential or its interaction with the host immune response. Neutrophils are the most abundant innate immune cell present in the gingival tissue and function to constrain the oral microbial challenge. However, some periodontal pathogens have developed strategies to evade phagocytosis and killing by neutrophils. Therefore, to begin to understand the role of P. stomatis in periodontitis, we studied its interactions with human neutrophils...
April 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28438509/effect-of-photodynamic-therapy-based-on-indocyanine-green-on-expression-of-apoptosis-related-genes-in-human-gingival-fibroblast-cells
#13
Samira Gharesi, Maryam Pourhajibagher, Nasim Chiniforush, Reza Raoofian, Mehrdad Hashemi, Sima Shahabi, Abbas Bahador
BACKGROUND: Periodontal diseases refer to inflammation of the gingiva, induction of apoptosis in human gingival fibroblast cells, destruction of the surrounding tissues, and early bone loss resulting in infections due to the pathogenic activity of the microorganisms and the host immune inflammatory responses. Recent investigations have suggested that antimicrobial photodynamic therapy (aPDT) can be an adjunct treatment therapy for periodontal infections. AIM: To prove the lack of side effects of PDT on periodontal tissues, we investigated the expression of BAX and BCL-2 genes that are involved in apoptosis after the PDT on human gingival fibroblast (HGF) cells...
April 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28437366/the-impact-of-residual-subgingival-cement-on-biological-complications-around-dental-implants-a-systematic-review
#14
Alessandro Quaranta, Zhuo Wei Lim, Joyce Tang, Vittoria Perrotti, Jonathan Leichter
OBJECTIVES: To perform a systematic review on the impact of residual subgingival cement on peri-implant diseases and crestal bone loss. MATERIAL AND METHODS: MEDLINE, SCOPUS, ISI Web of Knowledge and Cochrane Central Register of Controlled Trials (CENTRAL) databases were used to identify articles published without time limits. RESULTS: A total of 6 articles were selected for a total of 389 patients (687 implants). The studies were heterogeneous and had a moderate-to-high risk of bias, but met the inclusion criteria...
April 21, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28437035/the-association-between-oral-examination-findings-and-the-computed-tomographic-appearance-of-the-equine-temporomandibular-joint
#15
J L Carmalt, H Simhofer, A Bienert-Zeit, J E Rawlinson, C L Waldner
BACKGROUND: The temporomandibular joint (TMJ) forms the junction between the maxilla and mandible. Movement of the jaw and resulting masticatory forces have been extensively studied in the horse; however, less is known about the inter-relationship between this joint and oral and dental pathology. OBJECTIVES: To determine the association between specific oral and dental pathologies and anatomical variations of the TMJ imaged with computed tomography (CT) in horses with asymptomatic TMJs...
April 24, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28435362/awareness-about-the-effects-of-tobacco-consumption-on-oral-health-and-the-possibility-of-smoking-behavior-among-male-saudi-schoolchildren
#16
Muhammad Ashraf Nazir, Khalid Almas
OBJECTIVE: To investigate an association between the awareness about the effects of tobacco consumption on oral health and the likelihood of smoking among male schoolchildren. MATERIALS AND METHODS: A cross sectional study was conducted using a multistage random sampling technique. The participants (ages 15-19 years) were recruited from male public high schools in Greater Dammam in Saudi Arabia. A pretested questionnaire inquired participants' awareness about the effects of smoking on oral health...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434085/exploring-the-oral-microflora-of-preschool-children
#17
Wen Ren, Qun Zhang, Xuenan Liu, Shuguo Zheng, Lili Ma, Feng Chen, Tao Xu, Baohua Xu
The oral cavity is one of the most important and complicated habitats in our body and supports diverse microbial communities. In this study, we aimed to determine the bacterial diversity and composition of various oral micro-niches. Samples were collected from supragingival plaque, saliva, and tongue coating from 10 preschool children (30 samples total). 16S rRNA gene pyrosequencing dataset generated 314,639 clean reads with an average of 10,488 ± 2,787 reads per sample. The phyla Firmicutes, Proteobacteria, Actinobacteria, Bacteroidetes, and Fusobacteria were predominant, accounting for more than 90% of the total sequences...
April 22, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28433071/association-between-the-eruption-of-the-third-molar-and-caries-and-periodontitis-distal-to-the-second-molars-in-elderly-patients
#18
Yu-Hsiang Chou, Pei-Shan Ho, Kun-Yen Ho, Wen-Chen Wang, Kai-Fang Hu
The objective of this study was to verify whether caries and periodontal diseases, when present on the distal surface of the second molars (M2s), are associated with the eruption of the third molars (M3s). In this split-mouth study, we evaluated 70 elderly patients with unilateral maxillary or mandibular M3s who presented to the outpatient clinics of two hospitals. Patients underwent comprehensive oral examinations and radiographical measurements, and we assessed the outcomes of periodontal disease and caries...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28431542/effects-of-periodontal-treatment-on-the-medical-status-of-patients-with-type-2-diabetes-mellitus-a-pilot-study
#19
Joichiro Hayashi, Akihiko Hasegawa, Kohei Hayashi, Takafumi Suzuki, Makiko Ishii, Hideharu Otsuka, Kazuhiro Yatabe, Seiichi Goto, Junichi Tatsumi, Kitetsu Shin
BACKGROUND: Studies have demonstrated that periodontal disease is associated with the development of systemic complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this pilot study was to investigate which markers among various systemic disease parameters are affected by periodontal treatment in patients with T2DM. METHODS: Twelve patients with T2DM were given oral hygiene instructions and subsequent subgingival scaling and root planing...
April 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28429894/cytokine-and-metalloproteinases-in-gingival-fluid-from-patients-with-chronic-periodontitis
#20
Laura A Escalona, Patrizzia Mastromatteo-Alberga, María Correnti
The purpose of the present research was to determine the levels of IL- 1a, IL- 1 P, TNF-a, IL-6, IL-6sR, IL-8, IL-10, MMP-3 and EMP-8 in gingival crevicular fluid (GCF) of subjects with chronic periodontitis. Clinical measurements were carried out in 20 patients with chronic periodontitis and 11 periodontally healthy controls. The clinical indexes evalua- ted were: gingival index (GI), plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL); the measurements were taken at six sites per tooth in all teeth in each subject...
June 2016: Investigación Clínica
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