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https://www.readbyqxmd.com/read/28930556/osteoimmunology-the-nexus-between-bone-and-immune-system
#1
Hamid Y Dar, Zaffar Azam, Rajaneesh Anupam, Rajesh K Mondal, Rupesh K Srivastava
Osteoimmunology is an interdisciplinary research field which combines the existing fields of osteology (bone biology) and immunology under one umbrella. The observation that contributed enormously to the emergence of osteoimmunology as an independent field of investigation was the enhanced bone loss in various inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and periodontitis. T helper cells (Th1, Th2, Treg and Th17) along with various other immune cells (B cells, DC, macrophages etc.) are actively involved in bone homeostasis...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929053/thermoreversible-in-situ-gel-for-subgingival-delivery-of-simvastatin-for-treatment-of-periodontal-disease
#2
Swaminathan Rajendran, K Sathesh Kumar, S Ramesh, Suresh Ranga Rao
OBJECTIVE: The aim of this in vitro study was to formulate an in situ thermoreversible injectable gel with poloxamer (PM) and methylcellulose (MC) to deliver simvastatin (SMV) in a controlled manner. SUBJECTS AND METHODS: Preformulation studies (Fourier transform infrared and differential scanning calorimetry) to assess the interaction between SMV and MC and PM were performed before gel formulation. Keeping the concentration of SMV at 2.2%, the concentration of PM and MC was altered to formulate in situ thermosensitive gel at 37°C...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28928887/association-between-periodontal-disease-and-prostate-cancer-results-of-a-12-year-longitudinal-cohort-study-in-south-korea
#3
Jae-Hong Lee, Helen Hye-In Kweon, Jung-Kyu Choi, Young-Taek Kim, Seong-Ho Choi
The incidence of prostate cancer (PC) accompanying periodontal disease (PD) is anticipated to increase due to population aging. The aim of this study was to determine the association between PD and PC using data in the National Health Insurance Service-Health Examinee Cohort (NHIS-HEC). A random stratified sample of 187,934 South Koreans was collected from the NHIS database from 2002 to 2013. We assessed the relationship between PD and PC while adjusting for potential confounding factors (sex, age, household income, insurance status, residence area, hypertension, diabetes mellitus, cerebral infarction, angina pectoris, myocardial infarction, smoking status, alcohol intake, and regular exercise)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928784/association-of-stress-salivary-cortisol-level-and-periodontitis-among-the-inmates-of-a-central-prison-in-kerala
#4
Angel Fenol, Susan Jebi, Sajitha Krishnan, Jayachandran Perayil, Rajesh Vyloppillil, Anuradha Bhaskar, Sai Megha Menon, Ashitha Mohandas
BACKGROUND: The aim of this cross-sectional study was to evaluate the association between stress, salivary cortisol, and periodontitis among the inmates of the central prison. MATERIALS AND METHODS: Seventy inmates were grouped depending on their pocket depth into Group A (pocket depth >4 mm and <6 mm), Group B (at least four sites with pocket depth ≥6 mm), and Group C (pocket depth ≤3 mm). The clinical parameters such as the oral hygiene index-simplified, gingival index, pocket depth, and the clinical attachment levels (CALs) were recorded...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28927956/the-correlation-between-periodontal-health-status-and-suspectibility-to-infections-associated-with-craniomaxillofacial-osteosynthesis-plates
#5
Yahya Açil, Marie-Annett Heitzer, Aydin Gülses, Hendrik Naujokat, Rainer Podschun, Jörg Wiltfang, Christian Flörke
AIM: The aim of the present study was to demonstrate the possible relation between periodontal health status and infections associated with osteosynthesis materials (OMs) used in the oral and maxillofacial reconstruction. MATERIAL AND METHODS: The study group consisted of 32 individuals which were subdivided into two groups regarding their PSI scores. After the removal of the osteosynthesis plates, microbial colonization was assessed via microbiological cultivation, fluorescence microscopy and scanning electron microscopy...
August 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28925508/the-cost-effectiveness-of-oral-health-interventions-a-systematic-review-of-cost-utility-analyses
#6
Ruvini M Hettiarachchi, Sanjeewa Kularatna, Martin J Downes, Joshua Byrnes, Jeroen Kroon, Ratilal Lalloo, Newell W Johnson, Paul A Scuffham
OBJECTIVES: To assess the usage of cost-utility analysis (CUA) in oral health interventions and to evaluate the methods used and the reporting quality of CUA in publications on oral health interventions. METHODS: A systematic review was performed on literature published between 2000 and 2016 where cost-utility analyses of oral health interventions were included. The reporting quality of these oral health CUAs was assessed against the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist...
September 19, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28924232/infection-of-microglia-with-porphyromonas-gingivalis-promotes-cell-migration-and-an-inflammatory-response-through-the-gingipain-mediated-activation-of-protease-activated-receptor-2-in-mice
#7
Yicong Liu, Zhou Wu, Yurika Nakanishi, Junjun Ni, Yoshinori Hayashi, Fumiko Takayama, Yanmin Zhou, Tomoko Kadawaki, Hiroshi Nakanishi
Despite a clear correlation between periodontitis and cognitive decline in Alzheimer's disease, the precise mechanism underlying the relationship remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteinases termed gingipains that comprises Arg-gingipain (Rgp) and Lys-gingipain (Kgp). Rgp and Kgp are important in the bacterial mediated host cell responses and the subsequent intracellular signaling in infected cells. In the present study, we attempted to clarify the potential effects of Rgp and Kgp on the cellular activation of brain-resident microglia...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924229/variations-in-oral-microbiota-associated-with-oral-cancer
#8
Hongsen Zhao, Min Chu, Zhengwei Huang, Xi Yang, Shujun Ran, Bin Hu, Chenping Zhang, Jingping Liang
Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924191/metabolic-crosstalk-regulates-porphyromonas-gingivalis-colonization-and-virulence-during-oral-polymicrobial-infection
#9
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential (1) . Periodontitis, which is the sixth most prevalent infectious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo (3,4) . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
September 18, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28923364/tissue-specific-immunity-at-the-oral-mucosal-barrier
#10
REVIEW
Niki M Moutsopoulos, Joanne E Konkel
The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune control, including a diverse commensal microbiome, ongoing damage from mastication, and dietary and airborne antigens. However, how these tissue-specific cues participate in the training of immune responsiveness at this site is minimally understood. Moreover, the mechanisms mediating homeostatic immunity at this interface are not yet fully defined. Here we present basic aspects of the oral mucosal barrier and discuss local cues that may modulate and train local immune responsiveness...
September 8, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28921548/smoking-cessation-and-response-to-periodontal-treatment
#11
REVIEW
Foteini Alexandridi, Sotiria Tsantila, Eudoxie Pepelassi
Smoking has detrimental oral effects. The aim of this study was to review the literature related to the impact of smoking cessation on periodontal health, periodontal disease and periodontal treatment outcome as well as to review the smoking cessation strategies and the dentist's role in the smoking cessation effort. Smoking cessation seems to have a positive effect on the periodontium, to decrease the risk for incidence and progression of periodontitis and to lead to a non-significant trend for greater mean probing depth reductions after non-surgical treatment over a 12-month period...
September 16, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28920109/papillon-lef%C3%A3-vre-syndrome-a-series-of-three-cases-in-the-same-family-and-a-literature-review
#12
Jasbir D Upadhyaya, Dustin Pfundheller, Mohammed N Islam, Indraneel Bhattacharyya
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder that exhibits palmoplantar keratosis and early severe periodontitis. The oral disease affects both the primary and permanent dentitions leading to premature exfoliation of teeth. Various etiologic factors, such as genetic mutations, immunologic alterations, and bacteria have been implicated in PLS. Genetic mutations leading to the loss of function of cathepsin C (CTSC) gene, located on chromosome 11q14, is considered pivotal in this condition...
2017: Quintessence International
https://www.readbyqxmd.com/read/28919284/mmp-8-and-timp-1-are-associated-to-periodontal-inflammation-in-patients-with-rheumatoid-arthritis-under-methotrexate-immunosuppression-first-results-of-a-cross-sectional-study
#13
G Schmalz, I Davarpanah, J Jäger, R F Mausberg, B Krohn-Grimberghe, J Schmidt, R Haak, U Sack, Dirk Ziebolz
BACKGROUND: Aim of this cross-sectional study was the investigation of associations between different rheumatoid arthritis (RA)-related blood parameters and periodontal condition as well as selected periodontal pathogenic bacteria in RA patients under methotrexate (MTX) immunosuppression. METHODS: Periodontal probing depth (PPD), bleeding on probing (BOP) and clinical attachment loss (CAL) were assessed. Periodontal condition was classified into: no/mild and moderate or severe periodontitis (P)...
September 4, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28918172/melatonin-and-periodontal-tissues-molecular-and-clinical-perspectives
#14
REVIEW
Agata Rita Carpentieri, María Elena Peralta Lopez, Javier Aguilar, Verónica Mariana Solá
Periodontal disease is a frequent chronic inflammatory pathology that implies the destruction of the tissues supporting the teeth, which represents a high sanitary cost. It usually appears associated with other systemic conditions such as diabetes, metabolic syndrome, depression and Alzheimer disease among others. The presence of melatonin and its receptors in the oral cavity supports the hypothesis that this hormone could play a role in homeostasis of periodontal tissues. In the present review we will discuss the potential role of melatonin, a circadian synchronizing hormone, with proved antiinflammatory and antioxidant profile, in the pathogenesis and treatment of periodontitis...
September 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28915872/risk-factors-of-chronic-periodontitis-on-healing-response-a-multilevel-modelling-analysis
#15
J Song, H Zhao, C Pan, C Li, J Liu, Y Pan
BACKGROUND: Chronic periodontitis is a multifactorial polygenetic disease with an increasing number of associated factors that have been identified over recent decades. Longitudinal epidemiologic studies have demonstrated that the risk factors were related to the progression of the disease. A traditional multivariate regression model was used to find risk factors associated with chronic periodontitis. However, the approach requirement of standard statistical procedures demands individual independence...
September 15, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28914594/salivary-neuropeptides-stress-and-periodontitis
#16
Hady Haririan, Oleh Andrukhov, Michael Böttcher, Eleonore Pablik, Gernot Wimmer, Andreas Moritz, Xiaohui Rausch-Fan
BACKGROUND: Scientific evidence for psychological stress as a risk factor for periodontitis is fragmentary relying mostly on either questionnaire-based or biomarker studies. The aim of this study was to investigate Brain Derived Neurotrophic Factor, Substance P, Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), Calcitonin Gene Related Peptide and Adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28914249/visual-pedagogy-and-probiotics-for-hearing-impaired-children-a-pilot-study
#17
Amrita Sujlana, Ruchika Goyal, Parampreet Pannu, Shireen Opal, Palki Bansal
CONTEXT: Oral health care for children with special needs remains largely unmet. It is important that we should focus on preventive strategies for special children to help curtail and prevent oral diseases. AIM: This study aimed to assess the effect of visual pedagogy and probiotic mouth rinse on the periodontal health of hearing impaired children. MATERIALS AND METHODOLOGY: The study cohort consisted of twenty children with hearing impairment (HI) and 20 age-matched healthy children...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28914238/assessment-of-dental-caries-oral-hygiene-status-traumatic-dental-injuries-and-provision-of-basic-oral-health-care-among-visually-impaired-children-of-eastern-odisha
#18
Vinay Suresan, Diptajit Das, Avinash Jnaneswar, Kunal Jha, Gunjan Kumar, Goutham Bala Subramaniam
CONTEXT: The magnitude and severity of oral health problems in visually impaired population are worse than in general population, and they tend to have more untreated dental diseases and more problems accessing dental care. AIMS: The aim of this study is to assess dentition status and treatment needs, oral hygiene status, and traumatic dental injuries among institutionalized children attending special schools for the visually impaired in eastern Odisha. SETTINGS AND DESIGN: A descriptive, cross-sectional study was conducted using a universal sampling protocol...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28912945/comparison-of-er-yag-laser-and-ultrasonic-scaler-in-the-treatment-of-moderate-chronic-periodontitis-a-randomized-clinical-trial
#19
Reza Birang, Jaber Yaghini, Naeimeh Nasri, Nasim Noordeh, Pedram Iranmanesh, Alireza Saeidi, Narges Naghsh
Introduction: Periodontitis is an inflammatory periodontal disease that leads to tooth loss. Recently laser has been introduced as an alternative treatment for periodontitis. The aim of the present study was to compare the effect of Erbium-doped Yttrium Aluminum Garnet (Er:YAG) laser with ultrasonic scaler in patients with moderate chronic periodontitis. Methods: In this randomized single-blind clinical trial, 27 patients with moderate chronic periodontitis were selected. One quadrant of the patients was treated by Er:YAG laser and the other one by ultrasonic scaler...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#20
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
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