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https://www.readbyqxmd.com/read/29470839/embryonic-neurogenesis-in-echinoderms
#1
REVIEW
Veronica F Hinman, Robert D Burke
The phylogenetic position of echinoderms is well suited to revealing shared features of deuterostomes that distinguish them from other bilaterians. Although echinoderm neurobiology remains understudied, genomic resources, molecular methods, and systems approaches have enabled progress in understanding mechanisms of embryonic neurogenesis. Even though the morphology of echinoderm larvae is diverse, larval nervous systems, which arise during gastrulation, have numerous similarities in their organization. Diverse neural subtypes and specialized sensory neurons have been identified and details of neuroanatomy using neuron-specific labels provide hypotheses for neural function...
February 22, 2018: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29467866/notch-signaling-and-non-small-cell-lung-cancer
#2
Bin Zou, Xue-Liang Zhou, Song-Qing Lai, Ji-Chun Liu
Lung cancer is the leading cause of cancer-associated mortality worldwide. Elucidation of the pathogenesis and biology of lung cancer is critical for the design of an effective treatment for patients. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. The abnormal expression of Notch signaling pathway members is a relatively frequent event in NSCLC. The Notch signaling pathway serves important roles in cell fate determination, proliferation, differentiation and apoptosis. Increasing evidence supports the association of Notch signaling dysregulation with various types of malignant tumor, including NSCLC...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467848/differential-microrna-expression-in-the-prefrontal-cortex-of-mouse-offspring-induced-by-glyphosate-exposure-during-pregnancy-and-lactation
#3
Hua Ji, Linhao Xu, Zheng Wang, Xinli Fan, Lihui Wu
Glyphosate is the active ingredient in numerous herbicide formulations. The role of glyphosate in neurotoxicity has been reported in human and animal models. However, the detailed mechanism of the role of glyphosate in neuronal development remains unknown. Recently, several studies have reported evidence linking neurodevelopmental disorders (NDDs) with gestational glyphosate exposure. The current group previously identified microRNAs (miRNAs) that are associated with the etiology of NDDs, but their expression levels in the developing brain following glyphosate exposure have not been characterized...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467556/predictors-of-post-treatment-stenosis-in-cervical-esophageal-cancer-undergoing-high-dose-radiotherapy
#4
Jun Won Kim, Tae Hyung Kim, Jie-Hyun Kim, Ik Jae Lee
AIM: To evaluate toxicity and treatment outcome of high-dose radiotherapy (RT) for cervical esophageal cancer (CEC). METHODS: We reviewed a total of 62 consecutive patients who received definitive RT for stage I to III cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29467447/notch-signaling-represents-an-important-checkpoint-between-follicular-t-helper-and-canonical-t-helper-2-cell-fate
#5
Mark Dell'Aringa, R Lee Reinhardt
Type-2 immunity is regulated by two distinct CD4+ T-cell subsets. T follicular helper (Tfh) cells are required for humoral hallmarks of type-2 inflammation. T-helper type-2 (Th2) cells orchestrate type-2 inflammation in peripheral tissues, such as the lung and intestine. Given the importance of Notch signaling in the establishment of other CD4+ T-helper cell subsets, we investigated whether canonical Notch activation could differentially impact Tfh and Th2 cell fate during the induction of type-2 immunity...
February 21, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29467404/basal-condensation-of-numb-and-pon-complex-via-phase-transition-during-drosophila-neuroblast-asymmetric-division
#6
Zelin Shan, Yuting Tu, Ying Yang, Ziheng Liu, Menglong Zeng, Huisha Xu, Jiafu Long, Mingjie Zhang, Yu Cai, Wenyu Wen
Uneven distribution and local concentration of protein complexes on distinct membrane cortices is a fundamental property in numerous biological processes, including Drosophila neuroblast (NB) asymmetric cell divisions and cell polarity in general. In NBs, the cell fate determinant Numb forms a basal crescent together with Pon and is segregated into the basal daughter cell to initiate its differentiation. Here we discover that Numb PTB domain, using two distinct binding surfaces, recognizes repeating motifs within Pon in a previously unrecognized mode...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29467323/von-hippel-lindau-mutations-disrupt-vascular-patterning-and-maturation-via-notch
#7
Alexandra Arreola, Laura Beth Payne, Morgan H Julian, Aguirre A de Cubas, Anthony B Daniels, Sarah Taylor, Huaning Zhao, Jordan Darden, Victoria L Bautch, W Kimryn Rathmell, John C Chappell
Von Hippel-Lindau (VHL) gene mutations induce neural tissue hemangioblastomas, as well as highly vascularized clear cell renal cell carcinomas (ccRCCs). Pathological vessel remodeling arises from misregulation of HIFs and VEGF, among other genes. Variation in disease penetrance has long been recognized in relation to genotype. We show Vhl mutations also disrupt Notch signaling, causing mutation-specific vascular abnormalities, e.g., type 1 (null) vs. type 2B (murine G518A representing human R167Q). In conditional mutation retina vasculature, Vhl-null mutation (i...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29467246/the-transcriptome-of-early-chicken-embryo-reveal-signaling-pathways-governing-rapid-asymmetric-cellularization-and-lineage-segregation
#8
Young Sun Hwang, Minseok Seo, Bo Ram Lee, Hong Jo Lee, Young Hyun Park, Sang Kyung Kim, Hyung Chul Lee, Hee Jung Choi, Joon Yoon, Heebal Kim, Jae Yong Han
The phylogenomics and comparative functional genomics of avian species were investigated in the Bird10K project because of the important evolutionary position of birds and their value as a research model. However, the systematic profiling of transcriptional changes prior to oviposition has not been investigated in avian species because of the practical difficulties in obtaining pre-oviposited eggs. In this study, a total of 137 pre-oviposited embryos were collected from hen ovaries and oviducts and subjected to RNA sequencing analyses...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29466872/attenuation-of-egfl7-expression-inhibits-growth-hormone-producing-pituitary-adenomas-growth-and-invasion
#9
Qian Liu, Jianpeng Wang, Hongye Yang, Hua Gao, Chuzhong Li, Xiaolei Lan, Yazhuo Zhang
Invasiveness of growth hormone-producing pituitary adenomas (GHPAs) causes difficulties in safe and complete adenoma removal during surgery and often leads to high recurrence. Epidermal growth factor-like domain 7 (EGFL7) has been shown to be able to promote tumor angiogenesis, growth, invasiveness and metastasis through Notch signaling pathway. We previously demonstrated that EGFL7 was overexpressed in GHPAs. In this study, we report that EGFL7 and Notch2 (positive correlation with EGFL7) are overexpressed in invasive GHPA...
February 21, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29466731/spine-patterning-is-guided-by-segmentation-of-the-notochord-sheath
#10
Susan Wopat, Jennifer Bagwell, Kaelyn D Sumigray, Amy L Dickson, Leonie F A Huitema, Kenneth D Poss, Stefan Schulte-Merker, Michel Bagnat
The spine is a segmented axial structure made of alternating vertebral bodies (centra) and intervertebral discs (IVDs) assembled around the notochord. Here, we show that, prior to centra formation, the outer epithelial cell layer of the zebrafish notochord, the sheath, segments into alternating domains corresponding to the prospective centra and IVD areas. This process occurs sequentially in an anteroposterior direction via the activation of Notch signaling in alternating segments of the sheath, which transition from cartilaginous to mineralizing domains...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29464750/inhibition-of-adam10-in-satellite-cells-accelerates-muscle-regeneration-following-muscle-injury
#11
Sakiko Mizuno, Masaki Yoda, Masayuki Shimoda, Kazuhiro Chiba, Masaya Nakamura, Keisuke Horiuchi
Muscle injury is one of the most common orthopedic and sports disorders. For severe cases, surgical repair may be indicated; however, other than immobilization and the administration of anti-inflammatory drugs there is currently no effective conservative treatment for this condition. Satellite cells (SCs) are muscle-specific stem cells and are indispensable for muscle regeneration after muscle injury. SCs are activated upon muscle injury to proliferate and differentiate into myoblasts, which subsequently fuse into myofibers and regenerate the damaged muscle...
February 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29464702/identifying-differences-between-cut-marks-made-on-bone-by-a-machete-and-katana-a-pilot-study
#12
Penny McCardle, Elizabeth Stojanovski
The aim of this research was to identify characteristics specific to a machete and katana on three different bone types. One machete and two katanas were used to produce cut marks on Sus scrofa rib, flat and long bones. Fifty-nine cuts were produced by the katanas and 38 by the machete. The presence of flaking, feathering, peeling, micropeeling, chattering, microcurvature, scoop defect, and exit notch was noted, and bivariate associations between each characteristic and weapon type were assessed using Pearson's chi-square tests for independence and logistic regression models developed...
February 21, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29464088/deciphering-microrna-targets-in-pancreatic-cancer-using-mircomb-r-package
#13
Maria Vila-Casadesús, Elena Vila-Navarro, Giulia Raimondi, Cristina Fillat, Antoni Castells, Juan José Lozano, Meritxell Gironella
MiRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. They play important roles in cancer but little is known about the specific functions that each miRNA exerts in each type of cancer. More knowledge about their specific targets is needed to better understand the complexity of molecular networks taking part in cancer. In this study we report the miRNA-mRNA interactome occurring in pancreatic cancer by using a bioinformatic approach called miRComb, which combines tissue expression data with miRNA-target prediction databases (TargetScan, miRSVR and miRDB)...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463793/aberrant-regulation-of-notch3-signaling-pathway-in-polycystic-kidney-disease
#14
Jessica Idowu, Trisha Home, Nisha Patel, Brenda Magenheimer, Pamela V Tran, Robin L Maser, Christopher J Ward, James P Calvet, Darren P Wallace, Madhulika Sharma
Polycystic kidney disease (PKD) is a genetic disorder characterized by fluid-filled cysts in the kidney and liver that ultimately leads to end-stage renal disease. Currently there is no globally approved therapy for PKD. The Notch signaling pathway regulates cellular processes such as proliferation and de-differentiation, which are cellular hallmarks of PKD. Thus we hypothesized that the Notch pathway plays a critical role in PKD. Evaluation of protein expression of Notch signaling components in kidneys of Autosomal Recessive PKD (ARPKD) and Autosomal Dominant PKD (ADPKD) mouse models and of ADPKD patients revealed that Notch pathway members, particularly Notch3, were consistently upregulated or activated in cyst-lining epithelial cells...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462871/taming-the-notch-transcriptional-regulator-for-cancer-therapy
#15
REVIEW
Luca Tamagnone, Serena Zacchigna, Michael Rehman
Abstract Notch signaling is a highly conserved pathway in all metazoans, which is deeply involved in the regulation of cell fate and differentiation, proliferation and migration during development. Research in the last decades has shown that the various components of the Notch signaling cascade are either upregulated or activated in human cancers. Therefore, its downregulation stands as a promising and powerful strategy for cancer therapy. Here, we discuss the recent advances in the development of small molecule inhibitors, blocking antibodies and oligonucleotides that hinder Notch activity, and their outcome in clinical trials...
February 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29462049/suprasternal-transcatheter-aortic-valve-replacement-in-patients-with-marginal-femoral-access
#16
Andy C Kiser, Thomas G Caranasos, Mark D Peterson, David M Holzhey, Philipp Kiefer, L Wiley Nifong, Michael A Borger
OBJECTIVE: Recently, the PARTNER 2A trial reported results of transcatheter aortic valve replacement versus surgical aortic valve replacement in 2032 intermediate-risk patients at 2 years. Two hundred thirty-six patients (24%) required an access route other than transfemoral. Compared with transfemoral and surgical aortic valve replacement, nontransfemoral transcatheter aortic valve replacement was associated with a numerically higher rate of death and disabling stroke at 30 days. This underscores the need for a better alternative surgical approach for patients with marginal femoral access...
February 17, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29461492/layup-configuration-effect-on-notch-residual-strength-in-composite-laminates
#17
Venkateswaran Santhanakrishnan Balakrishnan, Holger Seidlitz, Sabine Weiß
The current trend shows an increasing demand for composites due to their high stiffness to weight ratio and the recent progress in manufacturing and cost reduction of composites. To combine high strength and stiffness in a cost-effective way, composites are often joined with steel or aluminum. However, joining of thermoset composite materials is challenging because circular holes are often used to join them with their metal counterparts. These design based circular holes induce high stress concentration around the hole...
February 20, 2018: Materials
https://www.readbyqxmd.com/read/29460660/early-repolarization-pattern-in-the-coronary-slow-flow-phenomenon
#18
Murat Sucu, Berzal Ucaman, Gökhan Altunbas
BACKGROUND: The coronary slow flow phenomenon (CSFP) is well-documented, and the early repolarization pattern (ERP) has recently been shown to be a risk factor for the development of malignant ventricular arrhythmias. METHODS: Those with true CSFP were included as cases and those with normal angiograms were included as controls. We assessed J-point elevation on surface electrocardiograms (ECGs) and defined ERP as notching or slurring of the terminal portion of the QRS takeoff...
February 20, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29459493/diagnostic-strategy-in-segmentation-defect-of-the-vertebrae-a-retrospective-study-of-73-patients
#19
Mathilde Lefebvre, Anne Dieux-Coeslier, Geneviève Baujat, Elise Schaefer, Saint-Onge Judith, Anne Bazin, Lucile Pinson, Tania Attie-Bitach, Clarisse Baumann, Melanie Fradin, Genevieve Pierquin, Sophie Julia, Chloé Quélin, Bérénice Doray, Sylvie Berg, Catherine Vincent-Delorme, Laetitia Lambert, Nadine Bachmann, Didier Lacombe, Bertrand Isidor, Nicole Laurent, Roume Joelle, Patricia Blanchet, Sylvie Odent, Dominique Kervran, Nathalie Leporrier, Carine Abel, Karine Segers, Fabienne Guiliano, Emmanuelle Ginglinger-Fabre, Angelo Selicorni, Alice Goldenberg, Salima El Chehadeh, Christine Francannet, Benedicte Demeer, Yannis Duffourd, Christel Thauvin-Robinet, Alain Verloes, Valerie Cormier-Daire, Jean Baptiste Riviere, Laurence Faivre, Julien Thevenon
BACKGROUND: Segmentation defects of the vertebrae (SDV) are non-specific features found in various syndromes. The molecular bases of SDV are not fully elucidated due to the wide range of phenotypes and classification issues. The genes involved are in the Notch signalling pathway, which is a key system in somitogenesis. Here we report on mutations identified in a diagnosis cohort of SDV. We focused on spondylocostal dysostosis (SCD) and the phenotype of these patients in order to establish a diagnostic strategy when confronted with SDV...
February 19, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29458214/effect-of-tetrahedral-dna-nanostructures-on-proliferation-and-osteo-odontogenic-differentiation-of-dental-pulp-stem-cells-via-activation-of-the-notch-signaling-pathway
#20
Mi Zhou, Nan-Xin Liu, Si-Rong Shi, Yong Li, Qi Zhang, Quan-Quan Ma, Tao-Ran Tian, Wen-Juan Ma, Xiao-Xiao Cai, Yun-Feng Lin
Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
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