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https://www.readbyqxmd.com/read/29455893/cognitive-behavioural-therapy-for-insomnia-cbt-i-to-treat-depression-a-systematic-review
#1
REVIEW
Jasmyn E A Cunningham, Colin M Shapiro
INTRODUCTION: Major depressive disorder is one of the most commonly diagnosed psychiatric illnesses, and it has a profound negative impact on an individual's ability to function. Up to 90% of individuals suffering from depression also report sleep and circadian disruptions. If these disruptions are not effectively resolved over the course of treatment, the likelihood of relapse into depression is greatly increased. Cognitive Behavioural Therapy for Insomnia (CBT-I) has shown promise in treating these sleep and circadian disturbances associated with depression, and may be effective as a stand-alone treatment for depression...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29454494/historical-perspectives-on-tardive-dyskinesia
#2
REVIEW
Stanley N Caroff, Gabor S Ungvari, David G Cunningham Owens
Tardive dyskinesia (TD) is a persistent hyperkinetic movement disorder associated with dopamine receptor blocking agents including antipsychotic medications. Although uncertainty and concern about this drug side effect has vacillated since its initial recognition 60 years ago, recent commercial interest in developing effective treatments has rekindled scientific and clinical interest after a protracted period of neglect. Although substantial research has advanced knowledge of the clinical features and epidemiology of TD, many fundamental questions raised by early investigators remain unresolved...
February 3, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29454151/humoral-response-to-john-cunningham-virus-during-pregnancy-in-multiple-sclerosis
#3
M Saraste, S Atula, K Hedman, S Hurme, A Jalkanen, M Sneck, H-M Surcel, A H Maghzi, L Airas
BACKGROUND: Pregnancy induces an immunosuppressive state in the mother to ensure immunological acceptance of the foetus. Impairment of cell-mediated immune responses may render the mother susceptible to intracellular pathogens. It is not presently known whether pregnancy alters the immunosurveillance for John Cunningham virus (JCV), an opportunistic pathogen associated with natalizumab treatment for multiple sclerosis (MS). OBJECTIVE: To evaluate whether the humoral immune response to JCV is altered during pregnancy among MS patients and healthy controls to get insight to potential pregnancy-induced alterations related to immune response to JCV during pregnancy...
February 9, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29453744/low-serum-ige-is-a-sensitive-and-specific-marker-for-common-variable-immunodeficiency-cvid
#4
Monica G Lawrence, Thamiris V Palacios-Kibler, Lisa J Workman, Alexander J Schuyler, John W Steinke, Spencer C Payne, Emily C McGowan, James Patrie, Ramsay L Fuleihan, Kathleen E Sullivan, Patricia L Lugar, Camellia L Hernandez, Douglas E Beakes, James W Verbsky, Thomas A E Platts-Mills, Charlotte Cunningham-Rundles, John M Routes, Larry Borish
Although small prior studies have suggested that IgE can be low in common variable immunodeficiency (CVID), the workup for patients with recurrent infections and suspected hypogammaglobulinemia does not include the routine measurement of serum IgE. We sought to test the hypothesis that low/undetectable serum IgE is characteristic of CVID by comparing the frequency of low/undetectable serum IgE in healthy controls and patients with CVID. We measured total serum IgE in a large multi-center cohort of patients with CVID (n = 354) and compared this to large population-based cohorts of children and adults...
February 17, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29446117/the-sociology-of-cancer-a-decade-of-research
#5
Anne Kerr, Emily Ross, Gwen Jacques, Sarah Cunningham-Burley
Biomedicine is often presented as the driving force behind improvements in cancer care, with genomics the latest innovation poised to change the meaning, diagnosis, treatment, prevention and lived experience of cancer. Reviewing sociological analyses of a diversity of patient and practitioner experiences and accounts of cancer during the last decade (2007-17), we explore the experiences of, approaches to and understandings of cancer in this period. We identify three key areas of focus: (i) cancer patient experiences and identities; (ii) cancer risk and responsibilities and (iii) bioclinical collectives...
February 15, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29440652/softening-due-to-grain-boundary-cavity-formation-and-its-competition-with-hardening-in-helium-implanted-nanocrystalline-tungsten
#6
W Streit Cunningham, Jonathan M Gentile, Osman El-Atwani, Chase N Taylor, Mert Efe, Stuart A Maloy, Jason R Trelewicz
The unique ability of grain boundaries to act as effective sinks for radiation damage plays a significant role in nanocrystalline materials due to their large interfacial area per unit volume. Leveraging this mechanism in the design of tungsten as a plasma-facing material provides a potential pathway for enhancing its radiation tolerance under fusion-relevant conditions. In this study, we explore the impact of defect microstructures on the mechanical behavior of helium ion implanted nanocrystalline tungsten through nanoindentation...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440071/non-invasive-immuno-metabolic-cardiac-inflammation-imaging-using-hyperpolarized-magnetic-resonance
#7
Andrew J Lewis, Jack J Miller, Angus Z Lau, Mary K Curtis, Oliver J Rider, Robin P Choudhury, Stefan Neubauer, Charles H Cunningham, Carolyn A Carr, Damian J Tyler
<u>Rationale:</u> Current cardiovascular clinical imaging techniques offer only limited assessment of innate immune cell driven inflammation, which is a potential therapeutic target in myocardial infarction (MI) and other diseases. Hyperpolarized magnetic resonance (MR) is an emerging imaging technology that generates contrast agents with 10-20,000 fold improvements in MR signal, enabling cardiac metabolite mapping. <u>Objective:</u> To determine whether hyperpolarized MR using [1- 13 C]pyruvate can assess the local cardiac inflammatory response following MI...
February 12, 2018: Circulation Research
https://www.readbyqxmd.com/read/29438303/cytoskeletons-in-the-closet-subversion-in-alphaherpesvirus-infections
#8
REVIEW
Christopher E Denes, Monica Miranda-Saksena, Anthony L Cunningham, Russell J Diefenbach
Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Human-tropic alphaherpesviruses are prevalent pathogens carried by more than half of the world's population; comprising herpes simplex virus (types 1 and 2) and varicella-zoster virus, these viruses are characterised by their ability to establish latency in sensory neurons...
February 13, 2018: Viruses
https://www.readbyqxmd.com/read/29438196/antiretroviral-drug-concentrations-in-hair-are-associated-with-virologic-outcomes-among-young-people-living-with-hiv-in-tanzania
#9
Zachary J Tabb, Blandina T Mmbaga, Monica Gandhi, Alexander Louie, Karen Kuncze, Hideaki Okochi, Aisa M Shayo, Elizabeth L Turner, Coleen K Cunningham, Dorothy E Dow
OBJECTIVE: We assessed the relationship of self-reported adherence versus antiretroviral therapy (ART) concentrations in hair with virologic outcomes among young people living with HIV. DESIGN: This was a cross-sectional study that enrolled young people living with HIV age 11-24 years, who attended a youth HIV clinic in Moshi, Tanzania. METHODS: ART adherence was assessed by self-report, drug concentration in hair samples, and plasma HIV-1 RNA measurements...
February 12, 2018: AIDS
https://www.readbyqxmd.com/read/29437928/exploring-the-antimicrobial-action-of-quaternary-amines-against-acinetobacter-baumannii
#10
Gregory A Knauf, Ashley L Cunningham, Misha I Kazi, Ian M Riddington, Alexander A Crofts, Vincent Cattoir, M Stephen Trent, Bryan W Davies
Quaternary amine compounds (QAC) are potent antimicrobials used to prevent the spread of pathogenic bacteria. While they are known for their membrane-damaging properties, QAC action has been suggested to extend beyond the surface to intracellular targets. Here we characterize the range of action of the QAC biocide benzalkonium chloride (BZK) against the bacterial pathogen Acinetobacter baumannii At high concentrations, BZK acts through membrane disruption, but at low concentrations we show that wide-spread protein aggregation is associated with BZK-induced cell death...
February 6, 2018: MBio
https://www.readbyqxmd.com/read/29437107/complete-closed-genome-sequence-of-nontoxigenic-invasive-corynebacterium-diphtheriae-bv-mitis-strain-iss-3319
#11
Camila Azevedo Antunes, Emily J Richardson, Joshua Quick, Pablo Fuentes-Utrilla, Georgia L Isom, Emily C Goodall, Jens Möller, Paul A Hoskisson, Ana Luiza Mattos-Guaraldi, Adam F Cunningham, Nicholas J Loman, Vartul Sangal, Andreas Burkovski, Ian R Henderson
The genome sequence of the human pathogen Corynebacterium diphtheriae bv. mitis strain ISS 3319 was determined and closed in this study. The genome is estimated to have 2,404,936 bp encoding 2,257 proteins. This strain also possesses a plasmid of 1,960 bp.
February 1, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29435863/evaluation-of-a-comprehensive-samhsa-service-program-for-individuals-experiencing-chronic-homelessness
#12
Molly Brown, Michael Rowe, Alison Cunningham, Allison N Ponce
No abstract text is available yet for this article.
February 12, 2018: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29435139/quantitative-high-throughput-phenotypic-screening-of-pediatric-cancer-cell-lines-identifies-multiple-opportunities-for-drug-repurposing
#13
Min Shen, Rosita Asawa, Ya-Qin Zhang, Elizabeth Cunningham, Hongmao Sun, Alexander Tropsha, William P Janzen, Eugene N Muratov, Stephen J Capuzzi, Sherif Farag, Ajit Jadhav, Julie Blatt, Anton Simeonov, Natalia J Martinez
Drug repurposing approaches have the potential advantage of facilitating rapid and cost-effective development of new therapies. Particularly, the repurposing of drugs with known safety profiles in children could bypass or streamline toxicity studies. We employed a phenotypic screening paradigm on a panel of well-characterized cell lines derived from pediatric solid tumors against a collection of ∼3,800 compounds spanning approved drugs and investigational agents. Specifically, we employed titration-based screening where compounds were tested at multiple concentrations for their effect on cell viability...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434467/genomic-analysis-using-regularized-regression-in-high-grade-serous-ovarian-cancer
#14
Yanina Natanzon, Madalene Earp, Julie M Cunningham, Kimberly R Kalli, Chen Wang, Sebastian M Armasu, Melissa C Larson, David Dl Bowtell, Dale W Garsed, Brooke L Fridley, Stacey J Winham, Ellen L Goode
High-grade serous ovarian cancer (HGSOC) is a complex disease in which initiation and progression have been associated with copy number alterations, epigenetic processes, and, to a lesser extent, germline variation. We hypothesized that, when summarized at the gene level, tumor methylation and germline genetic variation, alone or in combination, influence tumor gene expression in HGSOC. We used Elastic Net (ENET) penalized regression method to evaluate these associations and adjust for somatic copy number in 3 independent data sets comprising tumors from more than 470 patients...
2018: Cancer Informatics
https://www.readbyqxmd.com/read/29433607/developmental-coordination-disorder-psychopathology-and-iq-in-22q11-2-deletion-syndrome
#15
Adam C Cunningham, Sue Delport, Wendy Cumines, Monica Busse, David E J Linden, Jeremy Hall, Michael J Owen, Marianne B M van den Bree
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology. METHOD: Neurocognitive assessments and psychiatric interviews of 70 children with 22q11...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432338/patient-reported-experience-in-the-pediatric-emergency-department-what-matters-most
#16
Mher Barbarian, Andrea Bishop, Patricia Alfaro, Alain Biron, Daniel Adam Brody, Gabrielle Cunningham-Allard, Alexander Sasha Dubrovsky
INTRODUCTION: Although the Child Hospital Consumer Assessment of Healthcare Providers and Systems is a validated tool for the inpatient experience, it may not address features unique to the pediatric emergency department (PED). There is currently no publicly available validated patient-reported experience survey for the PED, and what matters most in this setting remains unknown. METHODS: Twelve semistructured interviews were conducted with a convenience sample of parents of children younger than 14 years at a Canadian PED...
February 9, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29432154/5-azacytidine-prevents-relapse-and-produces-long-term-complete-remissions-in-leukemia-xenografts-treated-with-moxetumomab-pasudotox
#17
Fabian Müller, Tyler Cunningham, Stephanie Stookey, Chin-Hsien Tai, Sandra Burkett, Parthav Jailwala, Maryalice Stetler Stevenson, Margaret C Cam, Alan S Wayne, Ira Pastan
Moxetumomab pasudotox (Moxe) is a chimeric protein composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A and kills CD22-expressing leukemia cells. It is very active in hairy-cell leukemia, but many children with relapsed/refractory acute lymphoblastic leukemia (ALL) either respond transiently or are initially resistant. Resistance to Moxe in cultured cells is due to low expression of diphthamide genes (DPH), but only two of six ALL blast samples from resistant patients had low DPH expression...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29432043/prehospital-application-of-hemostatic-agents-in-iraq-and-afghanistan
#18
Steven G Schauer, Michael D April, Jason F Naylor, Joseph K Maddry, Allyson A Arana, Michael A Dubick, Andrew D Fisher, Cord W Cunningham, Anthony E Pusateri
INTRODUCTION: Hemorrhage is the leading cause of death on the battlefield. Development of chitosan- and kaolin-based hemostatic agents has improved hemorrhage control options. Sparse data exists on the use of these agents in the prehospital, combat setting. We describe recent use of these agents and compare patients receiving hemostatic to the baseline population. METHODS: We used a series of emergency department (ED) procedure codes to identify patients within the Department of Defense Trauma Registry (DODTR) from January 2007 to August 2016...
February 12, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29430926/development-of-a-thiolysis-hplc-method-for-the-analysis-of-procyanidins-in-cranberry-products
#19
Chi Gao, David Cunningham, Haiyan Liu, Christina Khoo, Liwei Gu
The objective of this study was to develop a thiolysis HPLC method to quantify total procyanidins, ratio of A-type linkages, and A-type procyanidin equivalents in cranberry products. Cysteamine was utilized as a low-odor substitute of toluene-α-thiol for thiolysis depolymerization. Reaction temperature of 70 °C and reaction time of 20 min, in 0.3 M of HCl were determined to be an optimum depolymerization condition. Thiolytic products of cranberry procyanidins were separated on a RP-HPLC and identified using high resolution mass spectrometry...
February 12, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29430638/effect-of-area-level-socioeconomic-deprivation-on-risk-of-cognitive-dysfunction-in-older-adults
#20
Adrian McCann, Helene McNulty, Jan Rigby, Catherine F Hughes, Leane Hoey, Anne M Molloy, Conal J Cunningham, Miriam C Casey, Fergal Tracey, Maurice J O'Kane, Kevin McCarroll, Mary Ward, Katie Moore, J J Strain, Adrian Moore
OBJECTIVES: To investigate the relationship between area-level deprivation and risk of cognitive dysfunction. DESIGN: Cross-sectional analysis. SETTING: The Trinity, Ulster, and Department of Agriculture (TUDA) study from 2008 to 2012. PARTICIPANTS: Community-dwelling adults aged 74.0 ± 8.3 without dementia (N = 5,186; 67% female). MEASUREMENTS: Adopting a cross-jurisdictional approach, geo-referenced address-based information was used to map and link participants to official socioeconomic indicators of deprivation within the United Kingdom and the Republic of Ireland...
February 12, 2018: Journal of the American Geriatrics Society
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