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https://www.readbyqxmd.com/read/28212842/pathophysiological-consequences-of-receptor-mistraffic-tales-from-the-platelet-p2y12-receptor
#1
Margaret R Cunningham, Riyaad Aungraheeta, Stuart J Mundell
Genetic variations in G protein-coupled receptor (GPCR) genes can disrupt receptor function in a wide variety of human genetic diseases, including platelet bleeding disorders. Platelets are critical for haemostasis with inappropriate platelet activation leading to the development of arterial thrombosis, which can result in heart attack and stroke whilst decreased platelet activity is associated with an increased risk of bleeding. GPCRs expressed on the surface of platelets play key roles in regulating platelet activity and therefore function...
February 14, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28209745/platinum-fluoropyrimidine-and-paclitaxel-based-chemotherapy-in-the-treatment-of-advanced-anal-cancer-patients
#2
Francesco Sclafani, Federica Morano, David Cunningham, Chiara Baratelli, Eleftheria Kalaitzaki, David Watkins, Naureen Starling, Ian Chau, Sheela Rao
BACKGROUND: Although treatment of localized anal cancer (AC) is well established, very little evidence is available to inform the management of advanced tumors, and the prognosis of these patients remains poor. We have analyzed treatment pathways and outcomes of a single-institution series of advanced AC patients in order to provide insight into the management of this rare condition. MATERIALS AND METHODS: Inclusion criteria included epidermoid histology, inoperable locally recurrent or metastatic disease, and availability of full medical records...
February 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28209296/best-time-to-assess-complete-clinical-response-after-chemoradiotherapy-in-squamous-cell-carcinoma-of-the-anus-act-ii-a-post-hoc-analysis-of-randomised-controlled-phase-3-trial
#3
Robert Glynne-Jones, David Sebag-Montefiore, Helen M Meadows, David Cunningham, Rubina Begum, Fawzi Adab, Kim Benstead, Robert J Harte, Jill Stewart, Sandy Beare, Allan Hackshaw, Latha Kadalayil
BACKGROUND: Guidelines for anal cancer recommend assessment of response at 6-12 weeks after starting treatment. Using data from the ACT II trial, we determined the optimum timepoint to assess clinical tumour response after chemoradiotherapy. METHODS: The previously reported ACT II trial was a phase 3 randomised trial of patients of any age with newly diagnosed, histologically confirmed, squamous cell carcinoma of the anus without metastatic disease from 59 centres in the UK...
February 10, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28204548/in-vivo-modification-of-trna-with-an-artificial-nucleobase-leads-to-full-disease-remission-in-an-animal-model-of-multiple-sclerosis
#4
Sreeja Varghese, Michelle Cotter, Franciane Chevot, Claire Fergus, Colm Cunningham, Kingston H Mills, Stephen J Connon, John M Southern, Vincent P Kelly
No abstract text is available yet for this article.
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28203387/an-overview-of-available-drugs-for-management-of-opioid-abuse-during-pregnancy
#5
REVIEW
Jillian Laslo, Jon-Michael Brunner, Daniel Burns, Emily Butler, Autumn Cunningham, Ryan Killpack, Courtney Pyeritz, Kimberly Rinard, Jennifer Childers, Joseph Horzempa
The prevalence of opioid abuse in the United States has been steadily increasing over the last several years among many major demographics, including pregnant women. Rise in prenatal opioid abuse has resulted in subsequent escalation of neonatal abstinence syndrome incidence, prompting the US Congress to pass the Protecting Our Infants Act of 2015. This act specifically calls for a critical review of current treatment options for prenatal opioid abuse which may ultimately lead to the development of better therapies and a decreased incidence of neonatal abstinence syndrome...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28202587/it-s-cool-to-be-dominant-social-status-alters-short-term-risks-of-heat-stress
#6
Susan J Cunningham, Michelle L Thompson, Andrew E McKechnie
Climate change has potential to trigger social change. As a first step towards understanding mechanisms determining the vulnerability of animal societies to rising temperatures, we investigated interactions between social rank and thermoregulation in three arid-zone bird species: fawn-coloured lark (Mirafra africanoides, territorial); African red-eyed bulbul (Pycnonotus nigricans, loosely social) and sociable weaver (Philetairus socius, complex cooperative societies). We assessed relationships between body temperature (Tb), air temperature (Ta) and social rank in captive groups in the Kalahari Desert...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28202470/the-effect-of-foot-posture-on-capacity-to-apply-free-moments-to-the-ground-implications-for-fighting-performance-in-great-apes
#7
David R Carrier, Christopher Cunningham
In contrast to most other primates, great apes have feet in which the heel supports body weight during standing, walking and running. One possible advantage of this plantigrade foot posture is that it may enhance fighting performance by increasing the ability to apply free moments (i.e. force couples) to the ground. We tested this possibility by measuring performance of human subjects when performing from plantigrade and digitigrade (standing on the ball of the foot and toes) postures. We found that plantigrade posture substantially increased the capacity to apply free moments to the ground and to perform a variety of behaviors that are likely to be important to fighting performance in great apes...
February 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28196328/adherence-to-a-nurse-driven-feeding-protocol-in-a-pediatric-intensive-care-unit
#8
Carmen A Cunningham, Lindsay B Gervais, Vera C Mazurak, Vijay Anand, Daniel Garros, Katelynn Crick, Bodil M K Larsen
BACKGROUND: Patients admitted to pediatric intensive care units (PICUs) often experience prolonged periods without nutrition support, which may result in hospital-induced malnutrition and longer length of stay. Nurse-driven feeding protocols have been developed to prevent unnecessary interruptions or delays to nutrition support. The primary objective of this study was to identify compliance and reasons for noncompliance to a feeding protocol at a tertiary care hospital PICU in Canada...
February 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28196063/long-term-results-and-recurrence-patterns-from-scope-1-a-phase-ii-iii-randomised-trial-of-definitive-chemoradiotherapy-cetuximab-in-oesophageal-cancer
#9
T Crosby, C N Hurt, S Falk, S Gollins, J Staffurth, R Ray, J A Bridgewater, J I Geh, D Cunningham, J Blazeby, R Roy, T Maughan, G Griffiths, S Mukherjee
BACKGROUND: The SCOPE-1 study tested the role of adding cetuximab to conventional definitive chemoradiotherapy (dCRT), and demonstrated greater toxicity and worse survival outcomes. We present the long-term outcomes and patterns of recurrence. METHODS: SCOPE-1 was a phase II/III trial in which patients were randomised to cisplatin 60 mg m(-2) (day 1) and capecitabine 625 mg m(-2) bd (days 1-21) for four cycles +/- cetuximab 400 mg m(-2) day 1 then by 250 mg m(-2) weekly...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28195819/beh%C3%A3-et-uveitis
#10
Emmett T Cunningham, Ilknur Tugal-Tutkun, Moncef Khairallah, Annabelle A Okada, Bahram Bodaghi, Manfred Zierhut
No abstract text is available yet for this article.
February 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28193535/the-utility-of-nurse-managed-extracorporeal-life-support-in-an-adult%C3%A2-cardiac-intensive-care-unit
#11
Amy E Hackmann, Luke M Wiggins, Glenn P Grimes, Richard M Fogel, Felicia A Schenkel, Mark L Barr, Michael E Bowdish, Mark J Cunningham, Vaughn A Starnes
BACKGROUND: The use of extracorporeal life support (ECLS) worldwide has increased exponentially since 2009. The patient requiring ECLS demands an investment of hospital resources, including personnel. Educating bedside nurses to manage ECLS circuits broadens the availability of trained providers. METHODS: Experienced cardiothoracic intensive care unit (CTICU) nurses underwent training to manage ECLS circuits, including volume assessment, treatment of arterial blood gas values, the physiology of ECLS, and recognition of common emergencies...
February 10, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28188460/gender-differences-in-hiv-risk-behaviors-among-persons-involved-in-the-u-s-criminal-justice-system-and-living-with-hiv-or-at-risk-for-hiv-a-seek-test-treat-and-retain-harmonization-consortium
#12
Kelsey B Loeliger, Mary L Biggs, Rebekah Young, David W Seal, Curt G Beckwith, Irene Kuo, Michael S Gordon, Frederick L Altice, Lawrence J Ouellet, William E Cunningham, Jeremy D Young, Sandra A Springer
The U.S. female criminal justice (CJ) population is rapidly growing, yet large-scale studies exploring gender-specific HIV risk behaviors in the CJ population are lacking. This analysis uses baseline data on adults with a CJ history from eight U.S. studies in an NIH-funded "Seek, Test, Treat, Retain" harmonization consortium. Data were collected using a standardized HIV risk behavior assessment tool and pooled across studies to describe participants' characteristics and risk behaviors. Multilevel mixed-effects logistic regression models were used to test for gender-based behavior differences...
February 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28184880/alcohol-consumption-and-incident-stroke-among-older-adults
#13
Solveig A Cunningham, Aleena Mosher, Suzanne E Judd, Lisa M Matz, Edmond K Kabagambe, Claudia S Moy, Virginia J Howard
No abstract text is available yet for this article.
February 10, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28180043/preoperative-protective-endovascular-covered-stent-placement-followed-by-surgery-for-management-of-the-cervical-common-and-internal-carotid-arteries-with-tumor-encasement
#14
Michael R Markiewicz, Phillip Pirgousis, Curtis Bryant, James C Cunningham, Roi Dagan, Sukhwinder J Sandhu, Daniel A Siragusa, Arun Gopinath, Rui Fernandes
Objective The objective of this study was to report the outcomes on a preliminary cohort of patients with tumor encasement of either, or both, the cervical internal carotid artery (ICA) and common carotid artery (CCA) following preoperative covered stent placement and surgical resection. Setting This study was set at the University of Florida College of Medicine, Jacksonville, FL. Participants Subjects who received preoperative stenting of the cervical ICA/CCA before surgical resection of head and neck tumors between April 1, 2015, and July 31, 2015 were participated...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28176946/lower-education-among-low-income-brazilian-adolescent-females-is-associated-with-planned-pregnancies
#15
Alexandre Faisal-Cury, Karen M Tabb, Guilherme Niciunovas, Carrie Cunningham, Paulo R Menezes, Hsiang Huang
Adolescent pregnancy has social, economic, and educational consequences and is also linked to adverse perinatal outcomes. However, studies show a positive relationship between pregnancy and increased social status among low-income adolescents. This study aims to assess the association between planned pregnancy and years of schooling among low-income Brazilian adolescents. This is a secondary analysis of a cohort study conducted from May 2005 to March 2007 in public primary care clinics in São Paulo, Brazil...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28176877/structural-white-matter-and-functional-connectivity-alterations-in-patients-with-shoulder-apprehension
#16
Davide Zanchi, Gregory Cunningham, Alexandre Lädermann, Mehmet Ozturk, Pierre Hoffmeyer, Sven Haller
Previous functional magnetic resonance imaging (fMRI) findings indicate that shoulder apprehension is more complex than a pure mechanical problem of the shoulder, showing a direct modification in functional brain networks associated with motor inhibition and emotional regulation. The current study extends these findings by investigating further structural alterations in patients with shoulder apprehension compared to controls. 14 aged patients with shoulder apprehension (27.3 ± 2.0 years) and 10 matched healthy controls (29...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28176617/progressive-multifocal-leukoencephalopathy-in-a-kidney-transplant-recipient
#17
Federico Cicora, Javier Roberti
Progressive multifocal leukoencephalopathy (PML) is a debilitating and often fatal viral disease of the central nervous system. A 39-year-old male kidney transplant recipient presented to our hospital with weakness of the left arm and leg, his immunosuppressive regimen consisted of tacrolimus, mycophenolate sodium, and meprednisone. Magnetic resonance imaging of the brain revealed hypercellularity in neural tissue and a lesion affecting the right ventral and lateral areas of the thalamus and the posterior limb of the internal capsule...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28173838/osteoarthritis-associated-basic-calcium-phosphate-crystals-activate-membrane-proximal-kinases-in-human-innate-immune-cells
#18
Emma M Corr, Clare C Cunningham, Laura Helbert, Geraldine M McCarthy, Aisling Dunne
BACKGROUND: Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA joints and are associated with severe degeneration. They are known to activate macrophages, synovial fibroblasts, and articular chondrocytes, resulting in increased cell proliferation and the production of pro-inflammatory cytokines and matrix metalloproteases (MMPs)...
February 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28169872/project-engage-snowball-sampling-and-direct-recruitment-to-identify-and-link-hard-to-reach-hiv-infected-persons-who-are-out-of-care
#19
Amy Rock Wohl, Natasha Ludwig-Barron, Rhodri Dierst-Davies, Sonali Kulkarni, Jesse Bendetson, Wilbert Jordan, Robert Bolan, Terry Smith, William Cunningham, Mario J Pérez
INTRODUCTION: Innovative strategies are needed to identify and link hard-to-find persons living with HIV (PLWH) who are out of care(OOC). Project Engage, a health department-based project in Los Angeles County(LAC), used a mixed methods approach to locate and provide linkage for PLWH who have limited contact with HIV medical and non-medical services. METHODS: Incentivized social network referrals(SNR) and direct recruitment(DR) was used to identify eligible OOC alters for a linkage intervention that included HIV clinic selection, appointment and transportation support, reminder calls/texts and clinic navigation...
February 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28167563/phenotypic-and-molecular-antimicrobial-susceptibility-of-helicobacter-pylori
#20
Derrick Chen, Scott A Cunningham, Nicolynn C Cole, Peggy C Kohner, Jayawant N Mandrekar, Robin Patel
BACKGROUND: Failure to eradicate Helicobacter pylori infection is often a result of antimicrobial resistance, which for clarithromycin, is typically mediated by specific point mutations in the 23S rRNA gene. The purpose of this study was to define current patterns of antimicrobial susceptibility in H. pylori isolates derived primarily from the United States, and to survey for the presence of point mutations in the 23S rRNA gene and assess the ability of these mutations to predict phenotypic clarithromycin susceptibility...
February 6, 2017: Antimicrobial Agents and Chemotherapy
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