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https://www.readbyqxmd.com/read/29215644/response-to-newman-et-al
#1
Sumit Parikh, Amy Goldstein, Amel Karaa, Mary Kay Koenig, Irina Anselm, Catherine Brunel-Guitton, John Christodoulou, Bruce H Cohen, David Dimmock, Gregory M Enns, Marni J Falk, Annette Feigenbaum, Richard E Frye, Jaya Ganesh, David Griesemer, Richard Haas, Rita Horvath, Mark Korson, Michael C Kruer, Michelangelo Mancuso, Shana McCormack, Marie Josee Raboisson, Tyler Reimschisel, Ramona Salvarinova, Russell P Saneto, Fernando Scaglia, John Shoffner, Peter W Stacpoole, Carolyn M Sue, Mark Tarnopolsky, Clara Van Karnebeek, Lynne A Wolfe, Zarazuela Zolkipli Cunningham, Shamima Rahman, Patrick F Chinnery
No abstract text is available yet for this article.
December 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29215422/maternity-nurses-perceptions-of-implementation-of-the-ten-steps-to-successful-breastfeeding
#2
Emilie M Cunningham, Eva I Doyle, Rodney G Bowden
OBJECTIVE: The purpose of this study was to determine maternity nurses' perceptions of implementing the Ten Steps to Successful Breastfeeding. METHODS: An online survey and a focus group were used to evaluate perceptions of maternity nurses of implementing the Ten Steps to Successful Breastfeeding in an urban Texas hospital at the onset of the project initiation. Responses were transcribed and coded using Nvivo software. Thematic analysis was conducted and consensus was reached among the research team to validate themes...
January 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29214626/a-descriptive-analysis-of-data-from-the-department-of-defense-joint-trauma-system-prehospital-trauma-registry
#3
Stephen G Schauer, Michael D April, Jason F Naylor, Joshua J Oliver, Cord W Cunningham, Andrew D Fisher, Russ S Kotwal
The active battlefield is an environment of chaos and confusion. Depending on the scale of combat, the chaos and confusion often extend into the prehospital combat setting with multiple personnel and units involved in the chain of care of casualties. The chaos of the prehospital combat setting has led to limitations in the availability of data for performance improvement and research. The Department of Defense (DoD) Joint Trauma System (JTS) Prehospital Trauma Registry (PHTR) was developed in conjunction with the updated Tactical Combat Casualty Care (TCCC) card and a TCCC after action report (AAR), and currently serves as the prehospital repository and module of the DoD Trauma Registry (DoDTR)...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29212866/acquired-haemophilia-a-complicating-alemtuzumab-therapy-for-multiple-sclerosis
#4
Georgia McCaughan, Jennifer Massey, Ian Sutton, Jennifer Curnow
Alemtuzumab is a highly efficacious therapy used in the treatment of multiple sclerosis (MS), but uncoupling of T and B cell repopulation during immune reconstitution associates with an increasing range of secondary B cell-mediated autoimmune complications. A 34-year-old woman developed Graves' disease 11 months following an initial course of alemtuzumab treatment for MS. Nine months following the second treatment with alemtuzumab, the patient presented with spontaneous intramuscular and subcutaneous haemorrhage due to development of an inhibitory autoantibody to coagulation factor VIII...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29212532/delivery-of-screening-and-brief-intervention-for-unhealthy-alcohol-use-in-an-urban-academic-federally-qualified-health-center
#5
Marcus A Bachhuber, Megan A O'Grady, Henry Chung, Charles J Neighbors, Joseph DeLuca, Elenita M D'Aloia, Arelis Diaz, Chinazo O Cunningham
BACKGROUND: Screening and brief intervention (SBI) for unhealthy drinking has not been widely implemented in primary care partly due to reliance on physicians to perform it. METHODS: We implemented a model of nursing staff-delivered SBI for unhealthy drinking for adult patients receiving primary care at an academically-affiliated Federally Qualified Health Center in the Bronx, NY. Our model consisted of nursing staff screening all patients with the alcohol use disorders identification test consumption questions (AUDIT-C) and, if screening positive, providing BI or referral to specialty services...
December 7, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29211721/galaxy-growth-in-a-massive-halo-in-the-first-billion-years-of-cosmic-history
#6
D P Marrone, J S Spilker, C C Hayward, J D Vieira, M Aravena, M L N Ashby, M B Bayliss, M Béthermin, M Brodwin, M S Bothwell, J E Carlstrom, S C Chapman, Chian-Chou Chen, T M Crawford, D J M Cunningham, C De Breuck, C D Fassnacht, A H Gonzalez, T R Greve, Y D Hezaveh, K Lacaille, K C Litke, S Lower, J Ma, M Malkan, T B Miller, W R Morningstar, E J Murphy, D Narayanan, K A Phadke, K M Rotermund, J Sreevani, B Stalder, A A Stark, M L Strandet, M Tang, A Weiß
According to the current understanding of cosmic structure formation, the precursors of the most massive structures in the Universe began to form shortly after the Big Bang, in regions corresponding to the largest fluctuations in the cosmic density field. Observing these structures during their period of active growth and assembly-the first few hundred million years of the Universe-is challenging because it requires surveys that are sensitive enough to detect the distant galaxies that act as signposts for these structures and wide enough to capture the rarest objects...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29210313/pain-predicts-poorer-health-related-quality-of-life-in-childhood-onset-systemic-lupus-erythematosus-a-cohort-study
#7
Ji Li, Jordan T Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I Brunner
Objectives To investigate the predictive value of pain on health-related quality of life (HRQoL) among patients with childhood-onset systemic lupus erythematous (cSLE), as increased adverse psychosocial events are reported in patients with cSLE, but the predictive impact of psychological events on HRQoL remains unclear. Methods This cohort study recruited patients with cSLE from the Cincinnati Children's Hospital Medical Centre rheumatology clinic. Data regarding pain due to lupus in past week, and HRQoL, were collected during a baseline and 6-month follow-up visit...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29208933/the-anthelmintic-praziquantel-is-a-human-serotoninergic-g-protein-coupled-receptor-ligand
#8
John D Chan, Pauline M Cupit, Gihan S Gunaratne, John D McCorvy, Yang Yang, Kristen Stoltz, Thomas R Webb, Peter I Dosa, Bryan L Roth, Ruben Abagyan, Charles Cunningham, Jonathan S Marchant
Schistosomiasis is a debilitating tropical disease caused by infection with parasitic blood flukes. Approximately 260 million people are infected worldwide, underscoring the clinical and socioeconomic impact of this chronic infection. Schistosomiasis is treated with the drug praziquantel (PZQ), which has proved the therapeutic mainstay for over three decades of clinical use. However, the molecular target(s) of PZQ remain undefined. Here we identify a molecular target for the antischistosomal eutomer - (R)-PZQ - which functions as a partial agonist of the human serotoninergic 5HT2B receptor...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29208619/encouraging-translation-and-assessing-impact-of-the-centre-for-research-excellence-in-integrated-quality-improvement-rationale-and-protocol-for-a-research-impact-assessment
#9
Shanthi Ramanathan, Penny Reeves, Simon Deeming, Ross Stewart Bailie, Jodie Bailie, Roxanne Bainbridge, Frances Cunningham, Christopher Doran, Karen McPhail Bell, Andrew Searles
INTRODUCTION: There is growing recognition among health researchers and funders that the wider benefits of research such as economic, social and health impacts ought to be assessed and valued alongside academic outputs such as peer-reviewed papers. Research translation needs to increase and the pathways to impact ought to be more transparent. These processes are particularly pertinent to the Indigenous health sector given continued concerns that Indigenous communities are over-researched with little corresponding improvement in health outcomes...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29207444/abnormal-b-cell-development-in-systemic-lupus-erythematosus-what-the-genetics-tell-us
#10
REVIEW
Sarah Karrar, Deborah S Cunninghame Graham
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterised by B-cell dysfunction, production of autoantibodies directed towards cellular and nuclear components and tissue damage caused by immune complex deposition and inflammation. It largely affects women in the 3rd and 4th decades of life and is associated with significant morbidity and mortality. In healthy individuals, B-cells with auto-reactive receptors are selected out during B-cell maturation, starting at the initial stages of B-cell receptor development in the bone marrow, through to the fine tuning that occurs in activated mature B-cells in secondary lymphoid tissue...
December 5, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29205924/genomic-epidemiology-of-the-emerging-pathogen-batrachochytrium-dendrobatidis-from-native-and-invasive-amphibian-species-in-chile
#11
A Valenzuela-Sánchez, S J O'Hanlon, M Alvarado-Rybak, D E Uribe-Rivera, A A Cunningham, M C Fisher, C Soto-Azat
Emerging fungal diseases represent a threat to food security, animal and human health worldwide. Amphibian chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has been associated with catastrophic and well-documented amphibian population declines and extinctions. For the first time, Bd was cultured from native and non-native wild amphibians in Chile. Phylogenomic analyses revealed that Chilean isolates AVS2, AVS4 and AVS7 group within the global panzootic lineage of Bd (BdGPL) in a single highly supported clade that includes a genotype previously isolated from the United Kingdom...
December 5, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29204475/microarray-analysis-of-subcutaneous-adipose-tissue-from-mature-cows-with-divergent-body-weight-gain-after-feed-restriction-and-realimentation
#12
H C Cunningham, K M Cammack, K E Hales, H C Freetly, A K Lindholm-Perry
Body weight response to periods of feed restriction and realimentation is critical and relevant to the agricultural industry. The purpose of this study was to evaluate differentially expressed genes identified in subcutaneous adipose tissue collected from cows divergent in body weight (BW) gain after feed restriction and realimentation. We compared adipose samples from cows with greater gain based on average daily gain (ADG) during realimentation with samples from cows with lesser gain. Specifically, there were four comparisons including two comparing the high and low gain animals across each feeding period (feed restriction and realimentation) and two that compared differences in feed restriction and realimentation across high or low gain classifications...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29204066/alcohol-use-and-sexual-risk-behaviors-among-adolescents-with-psychiatric-disorders-a-systematic-review-and-meta-analysis
#13
Karlene Cunningham, David A Martinez, Lori A J Scott-Sheldon, Kate B Carey, Michael P Carey
Adolescents with psychiatric disorders appear to be at increased risk for acquiring HIV and other sexually transmitted infections; however, little is known about the prevalence of behavioral risk factors in this population. This meta-analysis aimed to assess the prevalence of alcohol use and sexual risk behaviors among adolescents with psychiatric disorders. Electronic database searches identified studies sampling adolescents diagnosed with psychiatric disorders and assessing both alcohol and sexual risk behaviors...
2017: Journal of Child & Adolescent Substance Abuse
https://www.readbyqxmd.com/read/29199476/sexual-violence-victimization-among-youth-presenting-to-an-urban-emergency-department-the-role-of-violence-exposure-in-predicting-risk
#14
Andria B Eisman, Quyen M Ngo, Yasamin Y Kusunoki, Erin E Bonar, Marc A Zimmerman PhD, Rebecca M Cunningham Md, Maureen A Walton PhD Mph
Sexual violence (SV) is a widespread public health problem among adolescents and emerging adults with significant short- and long-term consequences. Young people living in urban, disadvantaged communities with high rates of violence may be especially at risk for SV victimization. Understanding interconnections between different forms of violence is critical to reducing SV risk among youth. Participants were youth ( N = 599) ages 14 to 24 years ( M = 20.05, SD = 2.42) presenting to an urban emergency department with a Level 1 trauma designation as part of a prospective cohort study and followed-up for 24 months...
December 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29198490/overdose-and-adverse-drug-event-experiences-among-adult-patients-in-the-emergency-department
#15
Amy S B Bohnert, Maureen A Walton, Rebecca M Cunningham, Mark A Ilgen, Kristen Barry, Stephen T Chermack, Frederic C Blow
INTRODUCTION: Overdose is a leading cause of injury and death in the United States. Emergency Department (ED) patients have an elevated prevalence of substance use. This study describes overdose/adverse drug event experiences among adult ED patients to inform strategies to address overdose risk. METHODS: Patients seeking care at a large ED in the city of Flint, Michigan participated in a computerized self-assessment during 2011-2013 (n=4571). Overdose was assessed with a broad definition and included occurrences that could be considered adverse drug events...
November 16, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29197329/what-does-it-mean-when-people-say-that-they-have-received-expressions-of-concern-about-their-drinking-or-advice-to-cut-down-on-the-audit-scale
#16
John A Cunningham, Alexandra Godinho, Vladyslav Kushnir, Nicolas Bertholet
BACKGROUND: The Alcohol Use Disorders Identification Test (AUDIT) is a commonly used scale to measure severity of alcohol consumption that contains an item asking if anyone has expressed concern about your drinking or suggested you cut down. What does it mean when a participant says yes to this question? METHODS: Participants who were 18 or older and who drank at least weekly were recruited to complete a survey about their drinking from the Mechanical Turk platform...
December 2, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29196508/an-integrated-computational-and-experimental-study-uncovers-fut9-as-a-metabolic-driver-of-colorectal-cancer
#17
Noam Auslander, Chelsea E Cunningham, Behzad M Toosi, Emily J McEwen, Keren Yizhak, Frederick S Vizeacoumar, Sreejit Parameswaran, Nir Gonen, Tanya Freywald, Kalpana K Bhanumathy, Andrew Freywald, Franco J Vizeacoumar, Eytan Ruppin
Metabolic alterations play an important role in cancer and yet, few metabolic cancer driver genes are known. Here we perform a combined genomic and metabolic modeling analysis searching for metabolic drivers of colorectal cancer. Our analysis predicts FUT9, which catalyzes the biosynthesis of Ley glycolipids, as a driver of advanced-stage colon cancer. Experimental testing reveals FUT9's complex dual role; while its knockdown enhances proliferation and migration in monolayers, it suppresses colon cancer cells expansion in tumorspheres and inhibits tumor development in a mouse xenograft models...
December 1, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/29196074/acute-kidney-injury-in-pediatric-patients-receiving-allogeneic-hematopoietic-cell-transplantation-incidence-risk-factors-and-outcomes
#18
Kyung-Nam Koh, Anusha Sunkara, Guolian Kang, Amanda Sooter, Daniel A Mulrooney, Brandon Triplett, Ali Mirza Onder, John Bissler, Lea C Cunningham
Acute kidney injury (AKI) is a common adverse event following hematopoietic cell transplantation (HCT). AKI is associated with early death or chronic kidney disease among transplant survivors. However, large-scale pediatric studies based on standardized criteria are lacking. We performed a retrospective analysis of 1057 pediatric patients who received allogeneic HCT to evaluate the incidence and risk factors of AKI according to AKI Network criteria within the first 100 days of HCT. We also determined the effect of AKI on patient survival...
November 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29195483/temporal-characteristics-of-contextual-effects-in-sound-localization
#19
Ľuboš Hládek, Beáta Tomoriová, Norbert Kopčo
Two experiments examined plasticity induced by context in a simple target localization task. The context was represented by interleaved localization trials with the target preceded by a distractor. In a previous study, the context induced large response shifts when the target and distractor stimuli were identical 2-ms-noise clicks [Kopčo, Best, and Shinn-Cunningham (2007). J. Acoust. Soc. Am. 121, 420-432]. Here, the temporal characteristics of the contextual effect were examined for the same stimuli. Experiment 1 manipulated the context presentation rate and the distractor-target inter-stimulus interval (ISI)...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29195081/corrigendum-to-klinefelter-s-syndrome-47-xxy-is-in-excess-among-men-with-sj%C3%A3-gren-s-syndrome-clin-immunol-168-2016-25-29
#20
Valerie M Harris, Rohan Sharma, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Marta E Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Katherine A Siminovitch, Wan-Fai Ng, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, TorstenWitte, Xavier Mariette, Christopher J Lessard, John B Harley, Kathy L Sivils, R Hal Scofield
No abstract text is available yet for this article.
November 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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