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https://www.readbyqxmd.com/read/29045920/the-association-of-alcohol-consumption-patterns-with-self-rated-physical-health-and-psychiatric-distress-among-afghanistan-and-iraq-era-u-s-veterans
#1
Patrick S Calhoun, Sarah M Wilson, Eric A Dedert, Katherine C Cunningham, Thomas K Burroughs, Terrell A Hicks, Jean C Beckham, Harold S Kudler, Kristy Straits-Troster
Alcohol misuse is associated with negative mental and physical health outcomes, which presents a public health concern in veterans. However, less is known regarding outcomes among veterans with low to moderate alcohol consumption. This study included veterans with military service in Iraq and/or Afghanistan (N = 1083) who resided in the VA Mid-Atlantic region catchment area (North Carolina, Virginia, and parts of West Virginia). Participants completed a mailed survey that inquired about demographics, past-year alcohol consumption, self-rated physical health, and psychiatric symptoms...
September 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29045546/characterization-of-adipose-tissue-product-quality-using-measurements-of-oxygen-consumption-rate
#2
Thomas M Suszynski, David A Sieber, Kathryn Mueller, Allen L Van Beek, Bruce L Cunningham, Jeffrey M Kenkel
Background: Fat grafting is a common procedure in plastic surgery but associated with unpredictable graft retention. Adipose tissue (AT) "product" quality is affected by the methods used for harvest, processing and transfer, which vary widely amongst surgeons. Currently, there is no method available to accurately assess the quality of AT. Objectives: In this study, we present a novel method for the assessment of AT product quality through direct measurements of oxygen consumption rate (OCR)...
October 13, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29044033/-reduction-of-shoulder-dislocation-with-the-cunningham-method
#3
Thorsteinn H Gudmundsson, Hjalti Mar Bjornsson
INTRODUCTION: The Cunningham technique has been shown to be an effective and simple method to reduce a dislocated shoulder. It is based on the theory that the humeral head remains outside the glenoid fossa due to tension in the long biceps tendon. In the beginning of 2013 doctors at the emergency department in Landspitali University Hospital (LUH) in Reykjavik were instructed in the Cunningham method for reduction of anterior dislocation without sedation. The goal of this retrospective study was to evaluate the impact of its induction with regards to number of attempts, successful relocations, sedation, use of analgesics and length of stay in the ED...
September 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29042488/natural-killer-cells-mediate-pathophysiology-in-response-to-reduced-uterine-perfusion-pressure
#4
Jamil Elfarra, Lorena M Amaral, Maggie McCalmon, Jeremy D Scott, Mark W Cunningham, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C Cornelius
Preeclampsia is associated with hypertension, small-for-gestational-age babies and increased cytolytic natural killer (NK) cells. The specific role of cytolytic NK cells in the pathophysiology of preeclampsia has not been clearly defined. We hypothesized that Reduced Uterine Perfusion Pressure (RUPP) stimulates proliferation and cytolytic activation of NK cells, and that reducing NK cells in RUPP would prevent hypertension, intrauterine growth restriction, and inflammation in response to placental ischemia...
October 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29042410/h-and-pi-byproducts-of-glycosylation-affect-ca-2-%C3%A2-homeostasis-and-are-retrieved-from-the-golgi-complex-by-homologs-of-tmem165-and-xpr1
#5
Nathan A Snyder, Christopher P Stefan, Camille T Soroudi, Adam Kim, Carlos Evangelista, Kyle W Cunningham
Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H(+)) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and Gdt1) recycle luminal Pi and exchange luminal H(+) for cytoplasmic Ca(2+), respectively, thereby promoting growth of yeast cells in low Pi and low Ca2+ environments. As expected for reversible H(+)/Ca(2+) exchangers, Gdt1 also promoted growth in high Ca(2+) environments when the Golgi-localized V-ATPase was operational but had the opposite effect when the V-ATPase was eliminated...
October 17, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29041246/quantum-dot-emission-modulation-using-piezoelectric-photonic-crystal-mems-resonators
#6
Gloria G See, Anming Gao, Lu Xu, Ralph Nuzzo, Songbin Gong, Brian T Cunningham
Quantum dots (QDs) integration into photonic devices requires varied approaches to control and modulate their emission. We demonstrate voltage-tunable PC structures with integrated QDs over suspended piezoelectric aluminum nitride thin film resonators that modulate PC enhancement at MHz frequencies. When the piezoelectric device is actuated at its resonant mechanical frequency, the extracted QD emission direction is likewise modulated via the optical resonant frequency of the PC. Modulation uses nanometer-scale mechanical displacements, offering the potential for greater switching speed and improved mechanical robustness that is not subject to the effects of stiction with a scalable fabrication approach...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040465/the-fut2-secretor-variant-p-trp154ter-influences-serum-vitamin-b12-concentration-via-holo-haptocorrin-but-not-holo-transcobalamin-and-is-associated-with-haptocorrin-glycosylation
#7
Aneliya Velkova, Jennifer E L Diaz, Faith Pangilinan, Anne M Molloy, James L Mills, Barry Shane, Erica Sanchez, Conal Cunningham, Helen McNulty, Cheryl D Cropp, Joan E Bailey-Wilson, Alexander F Wilson, Lawrence C Brody
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency but this test has substantial false positive and false negative rates. We conducted genome-wide association studies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properties. We replicated reported associations between total circulating vitamin B12 concentrations and a common null variant in FUT2...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29038740/reverse-fosbury-flop-tear-of-the-rotator-cuff
#8
Jérôme Tirefort, Gregory Cunningham, Alexandre Lädermann
INTRODUCTION: "Fosbury flop" tear is an avulsion of the posterosuperior rotator cuff from the bone with reversal healing on its medial bursal-side. This case report describes a unique variant of Fosbury flop tear with a lesion of the musculotendinous junction that healed, for its tendon part, on the anterior humerus and coracoid process. CASE PRESENTATION: A 62-year-old man developed a posttraumatic painful shoulder with active loss of range of motion. Magnetic resonance arthrography demonstrated a lesion of the musculotendinous junction of the supraspinatus with healing of the tendon on the above-mentioned structures (reverse Fosbury flop)...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29037193/molecular-surveillance-of-pfhrp2-and-pfhrp3-deletions-in-plasmodium-falciparum-isolates-from-mozambique
#9
Himanshu Gupta, Gloria Matambisso, Beatriz Galatas, Pau Cisteró, Lidia Nhamussua, Wilson Simone, Jane Cunningham, N Regina Rabinovitch, Pedro Alonso, Franciso Saute, Pedro Aide, Alfredo Mayor
BACKGROUND: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnostic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. METHODS: Plasmodium falciparum isolates (n = 1162) collected in Southern Mozambique were assessed by RDTs, microscopy and/or 18SrRNA qPCR. pfhrp2 and pfhrp3 deletions were investigated in isolates from individuals who were negative by RDT but positive by microscopy and/or qPCR (n = 69) using gene-specific PCRs, with kelch13 PCR as the parasite DNA control...
October 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29031996/assessing-the-quality-of-dental-clinical-practice-guidelines
#10
Suhaym Mubeen, Kunal Patel, Ziba Cunningham, Niamh O'Rourke, Nikolaos Pandis, Martyn T Cobourne, Jadbinder Seehra
OBJECTIVES: The primary aim of this study was to evaluate the quality of published dental clinical guidelines using the AGREE II instrument. METHODS: Online searching of a wide range of organisations (national and International) was undertaken to identify dental clinical practice guidelines published between 2000-2014. The quality of each included guideline was assessed in relation to the AGREE II instrument by four assessors independently. Inter-rater agreement was assessed...
October 11, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29031798/viral-diversity-and-abundance-in-polluted-waters-in-kampala-uganda
#11
Evan O'Brien, Joyce Nakyazze, Huiyun Wu, Noah Kiwanuka, William Cunningham, John B Kaneene, Irene Xagoraraki
Waterborne viruses are a significant cause of human disease, especially in developing countries such as Uganda. A total of 15 virus-selective samples were collected at five sites (Bugolobi Wastewater Treatment Plant (WWTP) influent and effluent, Nakivubo Channel upstream and downstream of the WWTP, and Nakivubo Swamp) in July and August 2016. Quantitative PCR and quantitative RT-PCR was performed to determine the concentrations of four human viruses (adenovirus, enterovirus, rotavirus, and hepatitis A virus) in the samples...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29029781/returning-from-the-acidotic-abyss-mortality-in-trauma-patients-with-a-ph%C3%A2-%C3%A2-7-0
#12
Samuel W Ross, Bradley W Thomas, A Britton Christmas, Kyle W Cunningham, Ronald F Sing
No abstract text is available yet for this article.
October 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29029634/is-mmtv-associated-with-human-breast-cancer-maybe-but-probably-not
#13
Raisa Perzova, Lynn Abbott, Patricia Benz, Steve Landas, Seema Khan, Jordan Glaser, Coleen K Cunningham, Bernard Poiesz
BACKGROUND: Conflicting results regarding the association of MMTV with human breast cancer have been reported. Published sequence data have indicated unique MMTV strains in some human samples. However, concerns regarding contamination as a cause of false positive results have persisted. METHODS: We performed PCR assays for MMTV on human breast cancer cell lines and fresh frozen and formalin fixed normal and malignant human breast epithelial samples. Assays were also performed on peripheral blood mononuclear cells from volunteer blood donors and subjects at risk for human retroviral infections...
October 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/29029407/molecular-profiling-of-colorectal-pulmonary-metastases-and-primary-tumours-implications-for-targeted-treatment
#14
Sing Y Moorcraft, Thomas Jones, Brian A Walker, George Ladas, Eleftheria Kalaitzaki, Lina Yuan, Ruwaida Begum, Zakaria Eltahir, Andrew Wotherspoon, Angeles Montero-Fernandez, Larissa S Teixeira Mendes, David Gonzalez de Castro, Sanna Hulkki Wilson, Paula Proszek, Ye M To, Eliza Hawkes, Amitesh Roy, David Cunningham, Sheela Rao, David Watkins, Naureen Starling, Anne M Bowcock, Ian Chau
This study aimed to molecularly characterise colorectal pulmonary metastases (PM) and investigate whether their molecular profiles were concordant with those of the primary tumour. Clinical data and archival formalin fixed paraffin embedded tissue samples were retrospectively collected from patients who underwent ≥ 1 pulmonary metastasectomies for colorectal cancer between 1997-2012. Primary tumour and metastatic samples were analysed using a targeted capture sequencing panel of 46 cancer-associated genes...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029385/analyses-of-germline-variants-associated-with-ovarian-cancer-survival-identify-functional-candidates-at-the-1q22-and-19p12-outcome-loci
#15
Dylan M Glubb, Sharon E Johnatty, Michael C J Quinn, Tracy A O'Mara, Jonathan P Tyrer, Bo Gao, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Digna R Velez Edwards, Alicia Beeghly-Fadiel, Javier Benitez, Maria J Garcia, Marc T Goodman, Pamela J Thompson, Thilo Dörk, Matthias Dürst, Francesmary Modungo, Kirsten Moysich, Florian Heitz, Andreas du Bois, Jacobus Pfisterer, Peter Hillemanns, Beth Y Karlan, Jenny Lester, Ellen L Goode, Julie M Cunningham, Stacey J Winham, Melissa C Larson, Bryan M McCauley, Susanne Krüger Kjær, Allan Jensen, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Helga B Salvesen, Line Bjorge, Penny M Webb, Peter Grant, Tanja Pejovic, Melissa Moffitt, Claus K Hogdall, Estrid Hogdall, James Paul, Rosalind Glasspool, Marcus Bernardini, Alicia Tone, David Huntsman, Michelle Woo, Aocs Group, Anna deFazio, Catherine J Kennedy, Paul D P Pharoah, Stuart MacGregor, Georgia Chenevix-Trench
We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic analyses indicated that MEF2D and ZNF100 are targets of candidate outcome variants at 1q22 and 19p12, respectively. At 19p12, the chromatin interaction of a putative regulatory element with the ZNF100 promoter region correlated with candidate outcome variants...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027508/practice-based-small-group-learning-pbsgl-in-scotland-a-survey-of-registered-pharmacy-staff-and-general-practice-nurses
#16
David E Cunningham, Leon Zlotos
INTRODUCTION: Practice-based small group learning (PBSGL) has grown in primary healthcare in Scotland, and is used regularly by 2244 GPs and GP specialist trainees. The programme has been available to general practice nurses (GPNs) and pharmacy staff since uni-professional and inter-professional pilot studies were considered successful. Growth has been slower compared to GPs uptake but has now reached significant levels. It seemed timely to evaluate the use of the programme by these professions...
October 13, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/29025774/posterior-fossa-progressive-multifocal-leukoencephalopathy-first-presentation-of-an-unknown-autoimmune-disease
#17
Paulette Scholten, Peter Kralt, Bram Jacobs
We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central nervous system, caused by an opportunistic infection with John Cunningham virus. PML has previously been considered a lethal condition, but because of careful monitoring of patients with HIV and of patients using immunosuppressive drugs it is discovered in earlier stages and prognosis can be improved...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29024214/regenerative-medicine-stroke-survivor-and-carer-views-and-motivations-towards-a-proposed-stem-cell-clinical-trial-using-placebo-neurosurgery
#18
Nicola A Cunningham, Purva Abhyankar, Julie Cowie, Jayne Galinsky, Karen Methven
BACKGROUND: Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT). This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial (RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability. OBJECTIVE: To explore views and motivations towards a proposed 2-arm stem cell trial and identify factors that may impede and enhance participation...
October 12, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29024194/disrupted-cortico-limbic-connectivity-during-reward-processing-in-remitted-bipolar-i-disorder
#19
Sunny J Dutra, Vincent Man, Hedy Kober, William A Cunningham, June Gruber
OBJECTIVES: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms. METHODS: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI)...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29021402/hiv-exposed-infants-vaccinated-with-a-mf59-rgp120-vaccine-have-higher-magnitude-anti-v1v2-igg-responses-than-adults-immunized-with-the-same-vaccine
#20
Erin P McGuire, Youyi Fong, Christopher Toote, Coleen K Cunningham, Elizabeth J McFarland, William Borkowsky, Susan Barnett, Hannah L Itell, Amit Kumar, Glenda Gray, M Julianna McElrath, Georgia D Tomaras, Sallie R Permar, Genevieve G Fouda
In the RV144 vaccine trial, IgG responses against the HIV envelope variable loops 1 and 2 (V1V2) were associated with decreased HIV acquisition risk. We previously reported that infants immunized with a MF59 adjuvanted rgp120 vaccine developed higher magnitude anti-V1V2 IgG responses than adult RV144 vaccinees. To determine if the robust antibody response in infants is due to differences in vaccine regimens or to inherent differences between the adult and infant immune systems, we compared Env-specific IgG responses in adults and infants immunized with the same MF59 and Alum adjuvanted HIV envelope vaccines...
October 11, 2017: Journal of Virology
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