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Proliferative vitreoretinopathy

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https://www.readbyqxmd.com/read/29755825/bilateral-asymmetric-rhegmatogenous-retinal-detachment-in-a-patient-with-stickler-syndrome
#1
Caner Öztürk, Almila Sarıgül Sezenöz, Gürsel Yılmaz, İmren Akkoyun
Here we present the long-term anatomical and visual outcomes of bilateral asymmetric rhegmatogenous retinal detachment repair in a patient with Stickler syndrome. A 17-year-old girl presented with decreased visual acuity in both eyes for more than one year. Her best-corrected visual acuity (BCVA) was 0.1 in the right eye and 0.05 in the left eye. Slit-lamp anterior segment examination revealed subcapsular cataract in both eyes. Fundus examination showed bilateral rhegmatogenous retinal detachment, chronic retinal detachment accompanied by multiple retinal holes, tears and membranous fibrillary vitreous in the peripheral retina...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29749240/why-is-it-necessary-to-examine-retina-when-the-patient-suffers-from-aplastic-anemia
#2
D Tomcikova, A Gerinec, B Busanyova, M Gresikova, S Biskup, K Hortnagel
PURPOSES: To inform about a case of Revesz syndrome (RS) with initial ophthalmological symptomatology of severe proliferative vitreoretinopathy of the left eye (LE). After the aplastic anemia had developed, RS was established. The exudative retinopathy was successfully treated with photocoagulation on the right eye (RE). BACKGROUND: RS is characterized by fatal bone marrow failure, exudative retinopathy, neuroradiographic abnormalities, neurodevelopmental delay and skin abnormalities...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29747356/-research-on-the-surgery-treatment-and-etiology-of-fungal-endophthalmitis
#3
H Y Zhou, J J Ye, Y Y Chen, F T Dong
Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. The mean age of the patients was (45...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746442/community-associated-methicillin-resistant-staphylococcus-aureus-subretinal-abscess-in-a-nonbacteremic-patient-treated-with-internal-drainage-and-retinectomy
#4
Jessica F Yang, Kamal Kishore
PURPOSE: To report a case of community-associated methicillin-resistant Staphylococcus aureus subretinal abscess that continued to progress, despite intravitreal and systemic antibiotic therapy. METHODS: Retrospective chart review of a 77-year-old female patient with well-controlled diabetes mellitus who developed a left eye endophthalmitis and subretinal abscess from methicillin-resistant S. aureus colonization in the absence of any systemic focus of infection...
May 9, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29723860/animal-models-of-proliferative-vitreoretinopathy-and-their-use-in-pharmaceutical-investigations
#5
Huiyuan Hou, Eric Nudleman, Robert N Weinreb
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.
May 3, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29698960/protective-effects-of-fucoidan-on-epithelial-mesenchymal-transition-of-retinal-pigment-epithelial-cells-and-progression-of-proliferative-vitreoretinopathy
#6
Yao Zhang, Dongwan Zhao, Shuai Yang, Haipei Yao, Min Li, Chun Zhao, Jingfa Zhang, Guo-Tong Xu, Hui Li, Fang Wang
BACKGROUND/AIMS: Proliferative vitreoretinopathy (PVR) is a severe blinding complication of rhegmatogenous retinal detachment. Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is thought to play a pivotal role in the pathogenesis of PVR. Fucoidan, a marine extract, reportedly has many benefits effects in a variety of tissues and organs such as anti-inflammation, anti-oxidative stress, and anti-carcinogenesis. In this study, we investigated the potential role of fucoidan on EMT in RPE cells and its effect on the development of PVR...
April 23, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29670325/retinal-detachment-in-albinism
#7
Ahmad M Mansour, Jay Chhablani, J Fernando Arevalo, Lihteh Wu, Ravi Sharma, Suthasinee Sinawat, Tharikarn Sujirakul, Alexandre Assi, Wandsy M Vélez-Vázquez, Mohamad A Mansour, Ozcan Kayikcioglu, Cem Kucukerdonmez, Ali Kal
Purpose: To report the visual and anatomic outcomes of albino retinal detachment (ARD) repair. Methods: Collaborative retrospective analysis of ARD. Outcome measures were number of surgical interventions, final retinal reattachment, and best corrected visual acuity (BCVA) at last follow-up. Results: Seventeen eyes of 16 patients (12 males; mean age =37.8 years) had the following complications at presentation: macula off (14), total (7) or inferior detachment (5), proliferative vitreoretinopathy (5), detectable break (16), lattice (5), horseshoe tears (9), and giant tear or dialysis (4)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29621507/internal-limiting-membrane-peeling-in-macula-off-retinal-detachment-complicated-by-grade-b-proliferative-vitreoretinopathy
#8
Pauline Foveau, Bertrand Leroy, Jean-Paul Berrod, Jean-Baptiste Conart
PURPOSE: To investigate the clinical benefit of internal limiting membrane (ILM) peeling as a surgical adjunct in the repair of primary retinal detachment (RD) complicated by grade B proliferative vitreoretinopathy (PVR). DESIGN: Retrospective, interventional, comparative case series. METHODS: SETTING: Institutional. STUDY POPULATION: 75 consecutive patients who underwent vitrectomy for primary macula off RD complicated by grade B PVR...
April 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29620174/novel-nadph-oxidase-inhibitor-vas2870-suppresses-tgf%C3%A2-%C3%AE-%C3%A2-dependent-epithelial%C3%A2-to%C3%A2-mesenchymal-transition-in-retinal-pigment-epithelial-cells
#9
Jing Yang, Jing Li, Qun Wang, Yao Xing, Zizhu Tan, Qianyan Kang
NADPH oxidases (NOXs) are important in the pathophysiology of fibrotic diseases. The expression and activity of NOXs are regulated by growth factors, including transforming growth factor (TGF‑β). The proliferation of retinal pigment epithelial (RPE) cells following epithelial‑ to‑mesenchymal transition (EMT) is a major pathological change involved in proliferative vitreoretinopathy (PVR). The aim of the present study was to determine the effects of the novel NOX inhibitor VAS2870 on the TGF‑β‑dependent expression of NOX4 and associated cellular events in RPE cells...
April 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29618920/vitreous-levels-of-apolipoprotein-a1-and-retinol-binding-protein-4-in-human-rhegmatogenous-retinal-detachment-associated-with-choroidal-detachment
#10
Nannan Ding, Shasha Luo, Jinjin Yu, Ying Zhou, Zhifeng Wu
Purpose: This study aims to quantify the concentration of apolipoprotein A1 (APOA1) and retinol binding protein (RBP4) expressed in the vitreous humors of patients with rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD), rhegmatogenous retinal detachment (RRD), and idiopathic epimacular membrane (IEM). This study also aims to investigate the potential role of APOA1 and RBP4 as biomarkers of RRDCD. Methods: Enzyme-linked immunosorbent assay (ELISA) kits were used to obtain levels of APOA1 and RBP4 from the vitreous humor samples of 76 primary patients...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29617690/thrombin-generation-in-vitreous-and-subretinal-fluid-of-patients-with-retinal-detachment
#11
Verena C Mulder, Jeroen Bastiaans, Cornelis J M van Leuven, Jan C van Meurs, Cornelis Kluft
PURPOSE: To measure prothrombin fragments (F1+2) and thrombin-antithrombin complex (TAT) in vitreous and subretinal fluid (SRF) of rhegmatogenous retinal detachment (RRD) patients and to validate and further specify our earlier finding of increased thrombin activity in patients with proliferative vitreoretinopathy (PVR). METHODS: F1+2 and TAT were measured in 31 vitreous and 16 SRF samples using the Enzygnost® immunoassays. RESULTS: We found significant levels of F1+2 and TAT in the vitreous of all patients with RRD compared to patients with macular hole or macular pucker...
April 4, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29613981/phacomorphic-angle-closure-following-silicone-oil-tamponade-in-a-pediatric-patient
#12
Victoria C Leung, Simon Fung, Rajeev Muni, Asim Ali
PURPOSE: To report a case of phacomorphic glaucoma following retinal detachment repair with silicone oil in a pediatric patient. STUDY DESIGN: Case report. METHODS: A chart review was conducted at St. Michael's Hospital and The Hospital for Sick Children (Toronto, Canada), where the patient received ophthalmic care from July 28, 2015 onwards. RESULTS: A 14 year-old boy with a history of traumatic retinal detachment and proliferative vitreoretinopathy in the left eye, requiring two pars plana vitrectomies, membrane peel, and silicone oil tamponade, presented with one-day history of decreased vision in the left eye, severe headache, nausea, and vomiting...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29610848/photoreceptor-cell-derived-capn5-regulates-retinal-pigment-epithelium-cell-proliferation-through-direct-regulation-of-slit2-cleavage
#13
Yan Wang, Heming Li, Shihu Zang, Fanfan Li, Yingying Chen, Xiao Zhang, Zongming Song, Qing Peng, Feng Gu
Purpose: To identify the causative gene and investigate the corresponding mechanisms for an autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) family. Methods: Clinical examination and genetic analysis were performed in a Chinese ADNIV family. To dissect the molecular consequence, we used gene targeting to knock-in a patient's specific mutation in the mouse genome. Immunostaining and immunoprecipitation were harnessed to analyze the colocalization and interaction of CAPN5 with SLIT2 in photoreceptors...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29578200/epigallocatechin-gallate-curcumin-prevent-transforming-growth-factor-beta-1-induced-epithelial-to-mesenchymal-transition-in-arpe-19-cells
#14
Sivasankar Shanmuganathan, Venil N Sumantran, Narayanasamy Angayarkanni
Background & objectives: Proliferative vitreoretinopathy (PVR) is characterized by the presence of epiretinal membrane (ERM), which exerts traction and detaches the retina. Epithelial to mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells underlies ERM formation. Adjuvant therapies aimed at preventing recurrence of PVR after surgery mostly failed in clinical trials. This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-β1) in cultured ARPE-19 cells...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29569478/evaluation-of-hyaloid-retinal-relationship-during-triamcinolone-assisted-vitrectomy-for-primary-rhegmatogenous-retinal-detachment
#15
Dheepak Sundar, Brijesh Takkar, Pradeep Venkatesh, Rohan Chawla, Shreyas Temkar, Shorya Vardhan Azad, Rajpal Vohra
AIMS: To determine hyaloid-retinal relationship in primary rhegmatogenous retinal detachment during vitreous surgery. METHODS: This is a prospective, interventional study of patients (n = 72) undergoing triamcinolone-assisted 25G vitreous surgery for primary rhegmatogenous retinal detachment. Hyaloid-retinal relationship was noted intraoperatively to identify regions and patterns of firm attachment and was classified into subgroups. Analysis was done to determine association between hyaloid-retinal relationship patterns and preoperative findings: posterior vitreous detachment, proliferative vitreoretinopathy, type of retinal tear, the presence of peripheral degenerations, and postoperative outcomes...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29547015/levels-of-anti-retinal-antibodies-in-retinal-detachment-and-proliferative-vitreoretinopathy
#16
Reo Ichinohasama, Koji M Nishiguchi, Kosuke Fujita, Naoko Aizawa, Takashi Inoue, Erika Sasaki, Hiroshi Kunikata, Toru Nakazawa
PURPOSE: The purpose of the study is to investigate the correlation between intraocular anti-retinal antibodies and clinical measurements in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS: Aqueous humor and vitreous samples were collected from patients with RRD, PVR, and from control subjects with macular hole. The levels of total protein (TP), IgG, and anti-retinal antibodies were determined with a bicinchoninic acid assay, enzyme-linked immunosorbent assay, and dot blot, respectively...
March 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29546473/clinical-characteristics-and-outcomes-of-fall-related-open-globe-injuries-in-japan
#17
Shohei Morikawa, Yoshifumi Okamoto, Fumiki Okamoto, Naoki Inomoto, Hiroto Ishikawa, Kozo Harimoto, Tetsuo Ueda, Taiji Sakamoto, Tetsuro Oshika
PURPOSE: To investigate the clinical characteristics and visual outcomes in patients with fall-related open globe injuries and to evaluate differences between fall-related and non-fall-related open globe injuries in Japan. METHODS: A retrospective review of patients with open globe injury who presented to Japan-Clinical Research of Study (J-CREST) hospitals between 2005 and 2015 was enrolled. Clinical information including age, sex, initial visual acuity, final visual acuity, type of injury, status of the crystalline lens, zone of injury, wound length, presence of retinal detachment, proliferative vitreoretinopathy, expulsive hemorrhage, and endophthalmitis was recorded...
March 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29534723/plumbagin-induces-rpe-cell-cycle-arrest-and-apoptosis-via-p38-mark-and-pi3k-akt-mtor-signaling-pathways-in-pvr
#18
Haiting Chen, Huifang Wang, Jianbin An, Qingli Shang, Jingxue Ma
BACKGROUND: This study aimed to explore the effects of plumbagin (PLB) on ARPE-19 cells and underlying mechanism. METHODS: Cultured ARPE-19 cells were treated with various concentrations (0, 5, 15, and 25 μM) of PLB for 24 h or with 15 μM PLB for 12, 24 and 48 h. Then cell viability was evaluated by MTT assay and DAPI staining, while apoptosis and cell cycle progression of ARPE cells were assessed by flow cytometric analysis. Furthermore, the level of main regulatory proteins was examinated by Western boltting and the expression of relative mRNA was tested by Real-Time PCR...
March 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29532788/inhibitory-effects-of-plumbagin-on-retinal-pigment-epithelial-cell-epithelial-mesenchymal-transition-in-vitro-and-in-vivo
#19
Haiting Chen, Huifang Wang, Jianbin An, Qingli Shang, Jingxue Ma
BACKGROUND This study aimed to explore the effects of plumbagin (PLB) on epithelial-to-mesenchymal transition in retinal pigment epithelial (RPE) cells and in proliferative vitreoretinopathy (PVR) rabbit models. MATERIAL AND METHODS Rabbit RPE cells were exposed to various concentrations (0, 5, 15, and 25 µM) of PLB. Motility, migration, and invasion of PLB-treated cells were determined in vitro using Transwell chamber assays and scratch wound assays. The contractile ability was evaluated by cell contraction assay...
March 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29528982/novel-endoscope-assisted-vitreous-surgery-combined-with-atmospheric-endoscopic-technique-and-or-subretinal-endoscopic-technique-for-rhegmatogenous-retinal-detachment-with-grade-c-proliferative-vitreoretinopathy
#20
Tatsushi Kaga, Sho Yokoyama, Takashi Kojima, Hayato Mitamura, Toshio Mori, Taisuke Matsuda, Hiroyuki Sato, Norihiko Yoshida, Kazuo Ichikawa
PURPOSE: The purpose of this study was to investigate the clinical outcomes of novel endoscope-assisted vitreous surgery techniques in patients with rhegmatogenous retinal detachment complicated by Grade C proliferative vitreoretinopathy. METHODS: Eight consecutive patients who had undergone endoscope-assisted vitreous surgery for rhegmatogenous retinal detachment complicated by Grade C proliferative vitreoretinopathy were investigated. The peripheral vitreous was cut under air with the aid of endoscopic view (atmospheric endoscopic technique), and the subretinal proliferation was removed under subretinal endoscopic observation (subretinal endoscopic technique)...
March 8, 2018: Retina
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