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Proliferative vitreoretinopathy

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https://www.readbyqxmd.com/read/27919568/all-trans-retinoic-acid-suppresses-the-adhering-ability-of-arpe-19-cells-via-mitogen-activated-protein-kinase-and-focal-adhesion-kinase
#1
Yo-Chen Chang, Yuh-Shin Chang, Ming-Chu Hsieh, Horng-Jiun Wu, Meng-Hsien Wu, Chia-Wei Lin, Wen-Chuan Wu, Ying-Hsien Kao
This study investigated the signaling mechanism underlying the anti-adhesive effect of all-trans retinoic acid (ATRA) on retinal pigment epithelial ARPE-19 cells. Adhesion kinetics with or without ATRA treatment were profiled by adhesion assay. Surface coating with type IV collagen, fibronectin, laminin, but not type I collagen, significantly enhanced adhesion and spreading of ARPE-19 cells, while ATRA at subtoxic doses (ranging from 10(-7) to 10(-6) M) profoundly suppressed the extracellular matrix-enhanced adhesion ability...
November 16, 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27849448/myeloid-related-protein-14-mrp-14-s100a9-calgranulin-b-is-associated-with-inflammation-in-proliferative-diabetic-retinopathy
#2
Ahmed M Abu El-Asrar, Kaiser Alam, Mohammad M Siddiquei, Kathleen Van den Eynde, Ghulam Mohammad, Gert De Hertogh, Ghislain Opdenakker
PURPOSE: To investigate the expression of the leukocyte proteins myeloid-related protein (MRP)-8 and MRP-14 in proliferative diabetic retinopathy (PDR) and the effect of MRP-8/MRP-14 (calprotectin) heterodimer on induction of proinflammatory factors in human retinal microvascular endothelial cells (HRMEC). METHODS: Epiretinal membranes from 20 patients with PDR and 10 patients with proliferative vitreoretinopathy (PVR), vitreous fluid samples from PDR and non-diabetic subjects and HRMEC were studied by immunohistochemistry and Western blot analysis...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27846303/auranofin-inhibits-retinal-pigment-epithelium-cell-survival-through-reactive-oxygen-species-dependent-epidermal-growth-factor-receptor-mitogen-activated-protein-kinase-signaling-pathway
#3
Xiaodong Chen, Radouil Tzekov, Mingyang Su, Haiyan Hong, Wang Min, Aidong Han, Wensheng Li
Abnormal survival of retinal pigment epithelium (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR), a sight-threatening disease. In this study, we explored the effect of the anti-rheumatic agent auranofin (AF) on RPE cell survival and studied the underlying signaling mechanisms in vitro. Our results showed that AF inhibited ARPE-19 cell survival in a dose and time-dependent manner. Application of AF induced several effects: a significant decrease in total epidermal growth factor receptor (EGFR) and an increase in phosphorylated EGFR and mitogen-activated protein kinase (MAPK), including extracellular signal-regulated kinase (ERK), P38 mitogen-activated protein kinase (P38MAPK), c-Jun N-terminal kinase (JNK), c-Jun, mitogen activated protein kinase activated protein kinase 2(MAPKAPK2), and heat shock protein 27 (HSP27)...
2016: PloS One
https://www.readbyqxmd.com/read/27845192/controlling-drug-release-from-non-aqueous-environments-moderating-delivery-from-ocular-silicone-oil-drug-reservoirs-to-combat-proliferative-vitreoretinopathy
#4
Helen Cauldbeck, Maude Le Hellaye, Mark Long, Stephnie M Kennedy, Rachel L Williams, Victoria R Kearns, Steve P Rannard
In a number of cases of retinal detachment, treatment may require the removal of the vitreous humour within the eye and replacement with silicone oil to aid healing of the retina. The insertion of silicone oil offers the opportunity to also deliver drugs to the inside of the eye; however, drug solubility in silicone oil is poor and release from this hydrophobic drug reservoir is not readily controlled. Here, we have designed a range of statistical graft copolymers that incorporate dimethylsiloxane and ethylene glycol repeat units within the side chains, allowing short chains of oligo(ethylene glycol) to be solubilised within silicone oil and provide hydrogen bond acceptor sites to interact with acid functional drug molecules...
November 12, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27828913/long-term-results-of-total-retinectomy-in-cases-with-advanced-proliferative-vitreoretinopathy
#5
Murat Karacorlu, Isil Sayman Muslubas, Mumin Hocaoglu, Serra Arf, Mehmet Giray Ersoz
PURPOSE: To evaluate the long-term results of total retinectomy in patients with rhegmatogenous retinal detachment and severe proliferative vitreoretinopathy. METHODS: Seven eyes of 7 patients had pars plana vitrectomy, with or without pars plana lensectomy, and total retinectomy, with or without silicone oil tamponade, for the management of rhegmatogenous retinal detachment and proliferative vitreoretinopathy (Grade D1-3) after previous complex vitreoretinal surgery procedures...
November 8, 2016: Retina
https://www.readbyqxmd.com/read/27798121/minireview-fibronectin-in-retinal-disease
#6
Charles G Miller, Greg Budoff, Jonathan L Prenner, Jean E Schwarzbauer
Retinal fibrosis, characterized by dysregulation of extracellular matrix (ECM) protein deposition by retinal endothelial cells, pigment epithelial cells, and other resident cell-types, is a unifying feature of several common retinal diseases. Fibronectin is an early constituent of newly deposited ECM and serves as a template for assembly of other ECM proteins, including collagens. Under physiologic conditions, fibronectin is found in all layers of Bruch's membrane. Proliferative vitreoretinopathy (PVR), a complication of retinal surgery, is characterized by ECM accumulation...
January 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27787452/rhegmatogenous-retinal-detachment-after-intraarterial-chemotherapy-for-retinoblastoma-the-2016-founders-award-lecture
#7
Carol L Shields, Emil A T Say, Maria Pefkianaki, Carl D Regillo, Emi H Caywood, Pascal M Jabbour, Jerry A Shields
PURPOSE: To evaluate rhegmatogenous retinal detachment (RRD) in eyes with retinoblastoma after intraarterial chemotherapy (IAC). DESIGN: Retrospective case series. METHODS: Chart review. MAIN OUTCOME MEASURE: Development of RRD in the IAC era. RESULTS: Of 167 eyes in 157 consecutive patients, mean patient age at diagnosis of retinoblastoma was 19 months. Intraarterial chemotherapy was primary (75/167, 45%) or secondary (92/167, 55%)...
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27787448/smoking-is-a-risk-factor-for-proliferative-vitreoretinopathy-after-traumatic-retinal-detachment
#8
Dean Eliott, Tomasz P Stryjewski, Michael T Andreoli, Christopher M Andreoli
PURPOSE: To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy after open-globe trauma in smokers and nonsmokers. METHODS: A total of 892 patients comprising 893 open-globe injuries, in whom 255 eyes were diagnosed with a retinal detachment, and 138 underwent surgical repair were analyzed in a retrospective case-control study. Time to redetachment was examined using the Kaplan-Meier method and analysis of risk factors was analyzed using Cox proportional hazards modeling...
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27779559/traumatic-proliferative-vitreoretinopathy-clinical-and-histopathological-observations
#9
Ying Jin, Huijin Chen, Xiaojian Xu, Yuntao Hu, Changguan Wang, Zhizhong Ma
PURPOSE: To determine the phases of traumatic proliferative vitreoretinopathy after open globe injury by assessing cellular components, extracellular matrix constituents of proliferative vitreoretinopathy membranes, and intraretinal changes over time. METHODS: Twenty-one epiretinal and/or subretinal membrane specimens were obtained from 21 patients with open globe injuries. The patients were divided into Groups A (≤28 days), B (29-120 days), and C (>120 days) according to the interval between injury and vitrectomy...
October 21, 2016: Retina
https://www.readbyqxmd.com/read/27769586/clinical-and-ultrastructural-studies-of-epiretinal-pigmentary-deposits-after-retinectomy-with-silicone-oil
#10
Mira M Sachdeva, Frederick A Jakobiec, Anna M Stagner, Athanasios Papakostas, Dean Eliott
PURPOSE: Large relaxing retinectomies have become increasingly used in the repair of retinal detachment related to proliferative vitreoretinopathy (PVR). Retinectomies expose the retinal pigment epithelium (RPE) to the vitreous cavity; the direct effects of silicone oil on the RPE are only beginning to be understood. DESIGN: Retrospective case series. PARTICIPANTS: Twelve patients noted to develop pigmented epiretinal deposits at regularly scheduled follow-up visits after repair of complex retinal detachments using silicone oil tamponade and retinectomy...
October 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27769322/pars-plana-vitrectomy-with-silicone-oil-tamponade-in-failed-scleral-buckle-surgery
#11
Güner Ö Üney, Mehmet A Acar, Nurten Ünlü, Dicle Hazirolan, Zuleyha Yalniz-Akkaya, Firdevs Örnek
OBJECTIVE: This study aimed to evaluate the anatomical and functional outcomes of secondary pars plana vitrectomy (PPV) after failed scleral buckling (SB) surgery and to compare it with primary PPV for rhegmatogenous retinal detachment (RRD), including complicated proliferative vitreoretinopathy cases. DESIGN: Retrospective series in a tertiary care centre. PARTICIPANTS: One hundred and twenty consecutive patients. METHODS: The medical records of patients who underwent PPV with silicone oil tamponade for RRD were reviewed...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27698550/intravitreal-methotrexate-infusion-for-proliferative-vitreoretinopathy
#12
Ama Sadaka, Robert A Sisk, James M Osher, Okan Toygar, Melinda K Duncan, Christopher D Riemann
PURPOSE: The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI) during pars plana vitrectomy (PPV) for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR). METHODS: Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI. Clinical outcomes were determined from a retrospective medical chart review...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27688907/scleral-buckling-for-rhegmatogenous-retinal-detachment-associated-with-pars-planitis
#13
Yong-Kyu Kim, Wontae Yoon, Jae Kyoun Ahn, Sung Pyo Park
Purpose. To evaluate the surgical outcome of scleral buckling (SB) in rhegmatogenous retinal detachment (RRD) patients associated with pars planitis. Methods. Retrospective review of RRD patients (32 eyes of pars planitis RRD and 180 eyes of primary RRD) who underwent SB. We compared primary and final anatomical success rates and visual outcomes between two groups. Results. Primary and final anatomical success were achieved in 25 (78.1%) and 31 (96.8%) eyes in the pars planitis RRD group and in 167 eyes (92...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27682827/validity-of-aqueous-flare-measurement-in-predicting-proliferative-vitreoretinopathy-in-patients-with-rhegmatogenous-retinal-detachment
#14
Jean-Baptiste Conart, Soydan Kurun, François Ameloot, Fanny Tréchot, Bertrand Leroy, Jean-Paul Berrod
PURPOSE: To investigate aqueous flare as a preoperative predictor for later proliferative vitreoretinopathy (PVR) development in patients with rhegmatogenous retinal detachment (RD) and to determine the validity of this measurement in patients at low clinical risk for postoperative PVR. METHODS: This study included 100 eyes of 100 patients who underwent surgery for primary RD. Aqueous flare was determined preoperatively with a laser flare-cell meter (Kowa FM-500, Kowa Company Ltd, Tokyo, Japan)...
September 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27681600/early-surgical-treatment-of-retinal-hemangioblastomas
#15
Koen A van Overdam, Tom Missotten, Emine Kilic, Leigh H Spielberg
PURPOSE: To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. METHODS: Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery. All eyes underwent 23-gauge vitrectomy with lesion excision. One patient underwent ligation of the feeder vessel prior to lesion excision. Best-corrected visual acuity and clinical course were assessed during a follow-up period of at least 4 years...
September 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27640672/turning-the-fate-of-reprogramming-cells-from-retinal-disorder-to-regeneration-by-pax6-in-newts
#16
Martin Miguel Casco-Robles, Md Rafiqul Islam, Wataru Inami, Hibiki Vincent Tanaka, Ailidana Kunahong, Hirofumi Yasumuro, Shiori Hanzawa, Roman Martin Casco-Robles, Fubito Toyama, Fumiaki Maruo, Chikafumi Chiba
The newt, a urodele amphibian, has an outstanding ability- even as an adult -to regenerate a functional retina through reprogramming and proliferation of the retinal pigment epithelium (RPE) cells, even though the neural retina is completely removed from the eye by surgery. It remains unknown how the newt invented such a superior mechanism. Here we show that disability of RPE cells to regenerate the retina brings about a symptom of proliferative vitreoretinopathy (PVR), even in the newt. When Pax6, a transcription factor that is re-expressed in reprogramming RPE cells, is knocked down in transgenic juvenile newts, these cells proliferate but eventually give rise to cell aggregates that uniformly express alpha smooth muscle actin, Vimentin and N-cadherin, the markers of myofibroblasts which are a major component of the sub-/epi-retinal membranes in PVR...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27635776/risk-of-multiple-recurring-retinal-detachment-after-primary-rhegmatogenous-retinal-detachment-repair
#17
Philip Enders, Tina Schick, Friederike Schaub, Carolin Kemper, Sascha Fauser
PURPOSE: To evaluate functional and anatomical outcomes of patients with retinal redetachments (re-RD) after surgery for primary rhegmatogenous retinal detachment. METHODS: Medical records of eyes with re-RD after rhegmatogenous retinal detachment surgery between 1999 and 2014 at the Department of Ophthalmology, University of Cologne, Germany, were retrospectively evaluated. Data included preoperative and postoperative clinical findings, best-corrected visual acuity, presence and grade of proliferative vitreoretinopathy, surgical procedures, and complication rates...
September 15, 2016: Retina
https://www.readbyqxmd.com/read/27621784/intravitreal-injection-of-bevacizumab-in-primary-vitrectomy-to-decrease-the-rate-of-retinal-redetachment-a-randomized-pilot-study
#18
Adib Tousi, Hossein Hasanpour, Masoud Soheilian
PURPOSE: To evaluate the effect of intravitreal bevacizumab (IVB) as a surgical adjunct in prevention of proliferative vitreoretinopathy (PVR) after retinal detachment surgery. METHODS: In this controlled, randomized pilot study, 27 patients with primary retinal detachment undergoing pars plana deep vitrectomy were included. Of these, 12 received IVB at the end of procedure. The anatomic success and best corrected visual acuity (BCVA) were compared to the control group at months 3 and 6 postoperatively...
July 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27617647/-ocular-hypotension-how-the-retina-surgeon-sees-the-causes-and-therapeutic-options
#19
A M Joussen, O Strauß, S Winterhalter, M Klamann, T Dietrich-Ntoukas, B Müller
Ocular hypotension is a result of a lack of production or a loss of intraocular fluid. Intraocular inflammation, drugs, or proliferative vitreoretinopathy (PVR) with overgrowth of the ciliary body can result in reduced secretion of intraocular fluid. Loss of intraocular fluid can result from external loss, such as in fistulating surgery or trauma, or internally, e.g. from cyclodialysis clefts or retinal detachment. In this review, we discuss the causal therapy of ocular hypotension: fixation of the ciliary body, removal of ciliary body membranes, surgery for PVR, choice of tamponade, possibilities and limitations of an iris diaphragm, and pharmacological options...
September 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27600720/notch-signaling-modulates-proliferative-vitreoretinopathy-via-regulating-retinal-pigment-epithelial-to-mesenchymal-transition
#20
Jingjing Zhang, Gongqiang Yuan, Muchen Dong, Ting Zhang, Gao Hua, Qingjun Zhou, Weiyun Shi
Elevated Notch signaling has been verified in a large range of fibrotic diseases developed in the kidney, liver, and lung, inducing the development of the epithelial-mesenchymal transition (EMT). The aim of this study was to observe the involvement of Notch signaling in the EMT of retinal pigment epithelial (RPE) cells and the pathogenesis of proliferative vitreoretinopathy (PVR). In vitro cultivated human RPE cells (ARPE-19) were treated with 10 ng/mL transforming growth factor (TGF)-β1 for 24, 48, and 72 h...
September 7, 2016: Histochemistry and Cell Biology
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