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Proliferative vitreoretinopathy

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https://www.readbyqxmd.com/read/29282030/ratios-for-double-silicone-oil-endotamponade-in-vitro-observations-may-assist-with-ratio-selection
#1
Cheryl MacGregor, Abigail Jonas, Abdul Hanifudin, Jonathan Lochhead
BACKGROUND: Silicone oil tamponade is more frequently reserved for cases of complex retinal detachment. We describe the effects of different variations in oil ratios with the relatively unknown technique of double oil tamponade. METHODS: Retrospective case note review of nine patients with complex rhegmatogenous retinal detachment (RD). All cases had both superior and inferior breaks, mostly with associated proliferative vitreoretinopathy (PVR). All cases were treated with pars plana vitrectomy (PPV) and a double silicone oil endotamponade (DSOE) of both heavy silicone oil and conventional 'light' silicone oil...
December 28, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29280939/outcomes-of-vitrectomy-with-silicone-oil-tamponade-for-management-of-retinal-detachment-in-eyes-with-chorioretinal-coloboma
#2
Mumin Hocaoglu, Murat Karacorlu, Mehmet G Ersoz, Isil Sayman Muslubas, Serra Arf
PURPOSE: To estimate the outcomes of retinal detachment in eyes with chorioretinal coloboma managed by pars plana vitrectomy and silicone oil tamponade. METHODS: A retrospective chart review of 10 eyes (10 patients) who underwent pars plana vitrectomy for retinal detachment with chorioretinal coloboma. RESULTS: The average age at the time of the surgery was 29.8 ± 19.7 years. The mean follow-up period was 28.8 ± 28.4 months. The mean silicone oil tamponade duration was 9...
December 26, 2017: Retina
https://www.readbyqxmd.com/read/29246578/personalized-proteomics-in-proliferative-vitreoretinopathy-implicate-hematopoietic-cell-recruitment-and-mtor-as-a-therapeutic-target
#3
C Nathaniel Roybal, Gabriel Velez, Marcus Toral, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
PURPOSE: To profile vitreous cytokine expression of proliferative vitreoretinopathy (PVR) patients DESIGN: Case-control study. METHODS: Liquid biopsies were collected from two groups: control subjects (n=3) undergoing pars plana vitrectomy to remove an epiretinal membrane (ERM), and test subjects (n=7) with varying degrees of PVR. A high-throughput cytokine screen measured expression of 200 cytokines. Cytokine expression patterns were prospectively validated in separate cohorts of control patients and those with PVR-A, PVR-B, and PVR-C (n=10 for each group)...
December 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29234222/anatomical-and-functional-outcomes-of-retinectomies-in-retinal-detachments-complicated-by-proliferative-vitreoretinopathy
#4
Mohammad Idrees Adhi, Nisar Siyal, Sumbul Aziz
Purpose: To study anatomical and functional outcomes of retinectomies in rhegmatogenous retinal detachments complicated by proliferative vitreoretinopathy. Methods: This is a retrospective interventional consecutive case series of eyes with rhegmatogenous retinal detachments complicated by advanced proliferative vitreoretinopathy and managed by relaxing retinectomy over a period of seventeen years. Three-port pars plana vitrectomy included core vitrectomy and removal of all epi-retinal membranes...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29232332/outcomes-of-repeat-pars-plana-vitrectomy-after-failed-surgery-for-proliferative-vitreoretinopathy
#5
Ramsudha Narala, Nariman Nassiri, Chaesik Kim, Christian Mehregan, Sneha Padidam, Gary W Abrams
PURPOSE: To evaluate outcomes of repeat pars plana vitrectomy for proliferative vitreoretinopathy after previous failed pars plana vitrectomy. METHODS: This is a retrospective case series including 51 eyes of 50 patients who underwent repeat surgery after failed previous pars plana vitrectomy for proliferative vitreoretinopathy from 2000 to 2015 at the Kresge Eye Institute, Detroit, MI. Patients were classified into successful and unsuccessful groups. Success was defined as retinal reattachment, silicone oil removed, and best-corrected visual acuity (BCVA) ≥5/200 at the final follow-up visit...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29230977/scleral-buckling-using-a-non-contact-wide-angle-viewing-system-with-a-25-gauge-chandelier-endoilluminator
#6
Jaehyuck Jo, Byung Gil Moon, Joo Yong Lee
PURPOSE: To report the outcome of scleral buckling using a non-contact wide-angle viewing system with a 25-gauge chandelier endoilluminator. METHODS: Retrospective analyses of medical records were performed for 17 eyes of 16 patients with primary rhegmatogenous retinal detachment (RRD) without proliferative vitreoretinopathy who had undergone conventional scleral buckling with cryoretinopexy using the combination of a non-contact wide-angle viewing system and chandelier endoillumination...
December 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29223489/platelet-mass-index-can-be-a-reliable-marker-in-predicting-the-prognosis-of-retinopathy-of-prematurity-in-very-preterm-infants
#7
Levent Korkmaz, Osman Baştuğ, Ahmet Özdemir, Sabriye Korkut, Çağatay Karaca, Mustafa Ali Akın, Mehmet Adnan Öztürk
BACKGROUND: Retinopathy of prematurity (ROP) is a proliferative vitreoretinopathy resulting from vascular defect of the retina. The present study evaluates platelets, which are involved in VEGF storage, transport and release, and their functions with regard to the prognosis of the disease. The objective was to suggest a simple minimal invasive method that will facilitate the management of the disease and help clinicians in predicting the prognosis. METHODS: In this single center, retrospective, case-control study, we included a control group consisting of very preterm newborns (n = 83) at risk of ROP and a laser photocoagulation group including infants (n = 63) who received laser therapy during their follow-up examinations...
November 13, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29201199/lytak1-attenuates-proliferation-of-retinal-pigment-epithelial-cells-through-tgf-%C3%AE-mediated-epithelial-mesenchymal-transition-via-the-erk-akt-signaling-pathway
#8
Zhen Chen, Ninghua Ni, Yan Mei, Zhengrong Yang
Retinal pigment epithelial (RPE) cells have crucial roles in the initiation and development of human ophthalmic diseases. Our previous study suggested that transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a potential target in the progression and pathogenesis of human proliferative vitreoretinopathy disease. The present study further analyzed the role of TAK1 inhibitor, LYTAK1, in human RPE cells and explored the potential molecular mechanism of LYTAK1-mediated proliferation of human RPE cells...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29193875/dabigatran-inhibits-intravitreal-thrombin-activity
#9
Jeroen Bastiaans, Verena C Mulder, Jan C van Meurs, Marja Smits-Te Nijenhuis, Conny van Holten-Neelen, P Martin van Hagen, Willem A Dik
PURPOSE: Proliferative vitreoretinopathy (PVR) is a vitreoretinal disorder in which retinal pigment epithelial (RPE) cell activation contributes to both formation of fibrotic retinal membranes and inflammation. Vitreous of patients with PVR contains increased thrombin activity which induces profibrotic and proinflammatory programs in RPE cells. Inhibition of intravitreal thrombin activity may thus represent a therapeutic option for PVR. In this study, we examined the capacity of the clinically available direct thrombin inhibitor dabigatran to inhibit thrombin activity in vitreous fluids...
November 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29185844/postoperative-complications-of-scleral-buckling
#10
Thanos D Papakostas, Demetrios Vavvas
Scleral buckling has an important role in the repair of certain categories of rhegmatogenous retinal detachments. These include detachments in young phakic patients, detachments associated with dialysis, and also in conjuction with vitrectomy in patients who have sustained trauma or have developed proliferative vitreoretinopathy. However, it can be associated with significant postoperative complications. The most important ones are refractive change, intrusion or extrusion, infection, globe ischemia, and choroidal detachments, amongst others...
November 29, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29182404/evaluation-of-the-effect-of-everolimus-on-retinal-pigment-epithelial-cells-and-experimental-proliferative-vitreoretinopathy
#11
Hsi-Kung Kuo, Yi-Hao Chen, Yu-Hsia Kuo, Mu-Chan Ke, Ya-Chi Tseng, Pei-Chang Wu
PURPOSE: Failure of retinal detachment surgery is most commonly due to the development of proliferative vitreoretinopathy (PVR). Everolimus is an inhibitor of mammalian target of rapamycin (mTOR), and is available as oral tablets. In this study, we investigated the effect of everolimus on retinal pigment epithelial cells and modification of the severity of experimental PVR. METHODS: In our in vitro studies, primary culture of retinal pigment epithelium (RPE) cells was obtained from pigmented Rex rabbits...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29180845/clinical-outcomes-of-endoscope-assisted-vitrectomy-for-treatment-of-rhegmatogenous-retinal-detachment
#12
Sho Yokoyama, Takashi Kojima, Toshio Mori, Taisuke Matsuda, Hiroyuki Sato, Norihiko Yoshida, Tatsushi Kaga, R Theodore Smith, Kazuo Ichikawa
Summary: We evaluated the clinical outcomes for ophthalmic endoscope-assisted vitrectomy in consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD). The primary success rate was 98.4% (125/127) without performing a posterior drainage retinotomy or using perfluorocarbon liquids (PFCL) for subretinal fluid drainage. Purpose: To investigate the clinical outcomes of endoscope-assisted vitrectomy in patients with uncomplicated RRD. Methods: We examined 127 eyes from consecutive patients who underwent repair of RRD by 23- or 25-gauge endoscope-assisted vitrectomy, with a minimum follow-up of 3 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29165406/-the-significance-of-fibroblasts-in-experimental-modeling-of-proliferative-vitreoretinopathy
#13
I P Khoroshilova-Maslova, N L Leparskaya, E A Vorotelyak, A V Vasiliev
AIM: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy. MATERIAL AND METHODS: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0.1 ml) were injected into the vitreous cavity via the pars plana. The animals were followed up for 1 month and then made out of the experiment. The eyes were enucleated and fixed in 10% neutral buffered formalin for routine histological examination...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29164419/rhegmatogenous-retinal-detachment-in-uveitis
#14
Joeri De Hoog, Josianne C Ten Berge, Fahriye Groen, Aniki Rothova
BACKGROUND: Retinal detachment is more common among uveitis patients than in the general population. Here, we aimed to assess the prevalence of rhegmatogenous retinal detachment (RRD) in a uveitis population. METHODS: We retrospectively studied 851 uveitis patients, recording characteristics such as uveitis duration, anatomical location, and cause; RRD occurrence; proliferative vitreoretinopathy (PVR) at presentation; surgical approach; reattachment rate; and initial and final visual acuity (VA)...
November 21, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29160784/retinal-pigment-epithelium-choroid-graft-with-a-peripheral-retinotomy-for-exudative-age-related-macular-degeneration-long-term-outcome
#15
Saskia H M van Romunde, Antonio Polito, Antonio Peroglio Deiro, Massimo Guerriero, Grazia Pertile
PURPOSE: To investigate the long-term outcome of autologous retinal pigment epithelium -choroid transplantation with a peripheral retinotomy for exudative age-related macular degeneration. METHODS: In a retrospective study, we selected all patients who underwent a retinal pigment epithelium-choroid transplantation from 2007 through 2013. Exclusion criteria were age <60 years, <12 months of follow-up, and retinal pigment epithelium-choroid graft for other diseases than age-related macular degeneration...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29155697/acute-intraoperative-suprachoroidal-hemorrhage-during-small-gauge-pars-plana-vitrectomy
#16
Intira Sukpen, Jay M Stewart
PURPOSE: To report the intraoperative occurrence of acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy. METHOD: A review of a surgical patient who developed acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia. RESULTS: A 32-year-old obese woman with proliferative diabetic retinopathy and traction retinal detachment in the left eye who developed intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia while doing endolaser under air infusion...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29146307/long-term-visual-outcomes-and-safety-profile-of-27-gauge-pars-plana-vitrectomy-for-posterior-segment-disease
#17
M Ali Khan, Alexander Kuley, Christopher D Riemann, Maria H Berrocal, Rohit R Lakhanpal, Jason Hsu, Arunan Sivalingam, Allen C Ho, Carl D Regillo
PURPOSE: To report longer-term outcomes of 27-gauge pars plana vitrectomy (PPV) in eyes with posterior segment disease. DESIGN: Multicenter, retrospective, interventional case series. PARTICIPANTS: A total of 390 eyes of 360 patients undergoing 27-gauge PPV for a vitreoretinal surgery indication. INTERVENTION: Three-port, transconjunctival, 27-gauge PPV. MAIN OUTCOME MEASURES: Change in visual acuity (VA) and occurrence of intraoperative and postoperative complications with a minimum follow-up of 365 days...
November 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29133645/retinal-shortening-ultrasonic-evaluation-of-proliferative-vitreoretinopathy
#18
RANDOMIZED CONTROLLED TRIAL
Brijesh Takkar, Shreyas Temkar, Nripen Gaur, Pradeep Venkatesh, Rohan Chawla, Atul Kumar
PURPOSE: To evaluate the effect of extraretinal proliferative vitreoretinopathy (PVR) on retinal shortening in eyes with rhegmatogenous retinal detachment (RD) using ultrasound (USG) and objectively prove the presence of intraretinal PVR (iPVR). METHODS: This is a double-masked pilot prospective controlled case series. Patients with total RD planned for vitreoretinal surgery were included in the study. USG was used to determine retinal-to-choroidal length ratios (RCRs) in all the quadrants...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29125779/outcomes-of-recurrent-retinal-detachment-surgery-following-pars-plana-vitrectomy-for-rhegmatogenous-retinal-detachment
#19
Vikas Ambiya, Padmaja Kumari Rani, Raja Narayanan, Divya Balakrishnan, Jay Chhablani, Subhadra Jalali, Mudit Tyagi, Rajeev Reddy Pappuru
AIM: To study the anatomical and functional outcomes of recurrent retinal detachment (RD) surgery following pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment. METHODS: Retrospective analysis of 133 consecutive cases of recurrent RD. INCLUSION CRITERIA: age ≥18 years, recurrent RD following PPV ± encircling band for rhegmatogenous RD. EXCLUSION CRITERIA: age <18 years, post-endophthalmitis/tractional/exudative/combined RD, post-scleral buckle, primary surgery done at another institute...
November 10, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29115885/a-novel-lipid-prodrug-strategy-for-sustained-delivery-of-hexadecyloxypropyl-9-2-phosphonomethoxy-ethyl-guanine-hdp-pmeg-on-unwanted-ocular-proliferation
#20
Mei Chen, Jiangping Hou, Guilin Tan, Peng Xie, William R Freeman, James R Beadle, Karl Y Hostetler, Lingyun Cheng
Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high-risk time window for PVR to develop. Lipid prodrug of PMEG, hexadecyloxypropyl 9-[(2-phosphonomethoxy)ethyl]guanine (HDP-PMEG), was prepared and was evaluated as a pharmacological adjuvant to surgical management of PVR. A dose-escalation study determined that the highest nontoxic dose for intravitreal use in pigmented rabbits was 3 µg per eye...
November 2017: Drug Delivery
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