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Proliferative vitreoretinopathy

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https://www.readbyqxmd.com/read/28342867/gsk3%C3%AE-attenuates-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-and-metabolic-alterations-in-arpe-19-cells
#1
Li Huang, Cheng Zhang, Li Su, Zhengyu Song
While TGF-β1 is known to induce epithelial-mesenchymal transition (EMT), a major factor in the pathogenesis of proliferative vitreoretinopathy (PVR), in ARPE-19 cells. The molecular pathways involved in EMT formation have not yet to be fully characterized. In this study, we have found that TGF-β1-mediated induction of EMT in ARPE-19 cells varied in a dose- and time-dependent manner. Specifically, TGF-β1 inhibited GSK-3β by accelerating phosphorylation at ser9. GSK-3β inhibitor or knockdown of GSK-3β resulted in enhanced TGF-β1-mediated EMT, migration and collagen contraction in ARPE-19 cells, which were then abrogated by GSK-3β overexpression and PI3K/AKT inhibitor...
March 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28334846/dapl1-a-susceptibility-locus-for-age-related-macular-degeneration-acts-as-a-novel-suppressor-of-cell-proliferation-in-the-retinal-pigment-epithelium
#2
Xiaoyin Ma, Huirong Li, Yipin Wang, Jing Wang, Qinxiang Zheng, Jiajia Hua, Juan Yang, Li Pan, Fan Lu, Jia Qu, Ling Hou
The retinal pigment epithelium (RPE) forms a monolayer at the back of the vertebrate eye and is fundamental to retinal function and homoeostasis. During early development, RPE cells undergo rapid proliferation, but in the adult, they remain normally nonproliferative throughout life. Nevertheless, under pathological conditions such as in proliferative vitreoretinopathy or after retinal ablation, mature RPE cells can re-enter the cell cycle and form nodules or multiple cell layers. Here we show that Dapl1, whose human homolog represents a susceptibility locus for age-related macular degeneration (AMD), is highly up-regulated in quiescent but not proliferating RPE cells and that experimental overexpression of DAPL1 in proliferating RPE cells inhibits their proliferation...
February 22, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333880/twenty-five-gauge-pars-plana-vitrectomy-in-complex-retinal-detachments-associated-with-giant-retinal-tear
#3
Vinod Kumar, Devesh Kumawat, Anju Bhari, Parijat Chandra
PURPOSE: To study the structural and functional outcomes of 25-gauge pars plana vitrectomy in giant retinal tear-associated retinal detachments. METHODS: Seventeen eyes of 17 patients with giant retinal tear, who underwent 25-gauge pars plana vitrectomy over a period of 15 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. RESULTS: Giant retinal tears were mostly traumatic (35...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28304388/pirfenidone-inhibits-post-traumatic-proliferative-vitreoretinopathy
#4
B N M K Khanum, R Guha, V P Sur, S Nandi, S K Basak, A Konar, S Hazra
PurposeThe purpose of the study was to evaluate the efficacy and safety of intravitreal pirfenidone for inhibition of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.Patients and methodsPenetrating trauma was induced on the retina of rabbit and treated either with 0.1 ml of phosphate-buffered saline (PBS) or 0.1 ml of 0.5% pirfenidone, and development of PVR was evaluated clinically and graded after 1 month. Histopathology and immunohistochemistry with transforming growth factor beta (TGFβ), alpha smooth muscle actin (αSMA), and collagen-1 were performed to assess the fibrotic changes...
March 17, 2017: Eye
https://www.readbyqxmd.com/read/28298707/outcome-of-primary-rhegmatogenous-retinal-detachment-surgery-in-a-tertiary-referral-centre-in-northern-ireland-a-regional-study
#5
Michael A Mikhail, George Mangioris, Giuseepe Casalino, Stuart McGimpsey, James Sharkey, Richard Best, Wing C Chan
PURPOSE: To report the primary and final success, functional outcome and complication rates of patients with primary rhegmatogenous retinal detachment (RRD) who underwent retinal detachment surgery in a tertiary referral centre in Northern Ireland. VENUE: Vitreoretinal service, Royal Victoria Hospital, Belfast, Northern Ireland. METHODS: This is a retrospective case series of all patients who underwent primary RRD repair between 1st of January 2013 and 31st of December 2013...
January 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/28289950/heavy-and-standard-silicone-oil-intraocular-inflammation
#6
REVIEW
Andrea Russo, Francesco Morescalchi, Simone Donati, Elena Gambicorti, Claudio Azzolini, Ciro Costagliola, Francesco Semeraro
PURPOSE: Proliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier-than-water intraocular tamponades have been developed to improve inferior tamponading properties, and their chemical compositions have been substantially improved over the years, in parallel with developments in vitrectomy instrumentation and surgical techniques. Herein we present an updated review of the clinical use of standard formulations and HSO, focusing on analysis of the intraocular inflammation associated with endotamponade agents, and comparison of the adverse effects of these agents on the physical and biological properties of the eye...
March 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28275595/reactive-retinal-astrocytic-tumor-focal-nodular-gliosis-a-case-report
#7
Lauren E Hudson, Pia R Mendoza, Jiong Yan, Hans E Grossniklaus
PURPOSE: To report the clinical and histopathological findings of a reactive retinal astrocytic tumor (RRAT) that progressed to massive retinal gliosis. OBSERVATIONS: The patient presented with an elevated, white-yellow retinal mass and extensive retinal exudation in the left eye. Progressive enlargement of the mass and proliferative vitreoretinopathy eventually led to phthisis bulbi and enucleation. Histologically, the mass showed a predominant astrocytic component with intense glial fibrillary acidic protein staining, hyperplasia, fibrous metaplasia, and osseous metaplasia of the retinal pigment epithelium...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28272285/efficacy-of-intravitreal-injection-of-bevacizumab-in-vitrectomy-for-patients-with-proliferative-vitreoretinopathy-retinal-detachment-a-meta-analysis-of-prospective-studies
#8
Xin-Yu Zhao, Song Xia, Er-Qian Wang, You-Xin Chen
PURPOSE: To evaluate the effect of intravitreal injection of bevacizumab in vitrectomy for patients with proliferative vitreoretinopathy (PVR)-related retinal detachment. METHODS: The PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from their earliest entries through October, 2016, to identify the studies that had evaluated the effects of intravitreal injection of bevacizumab in vitrectomy for eyes with PVR-related retinal detachment...
March 7, 2017: Retina
https://www.readbyqxmd.com/read/28264049/vitreous-advanced-glycation-endproducts-and-%C3%AE-dicarbonyls-in-retinal-detachment-patients-with-type-2-diabetes-mellitus-and-non-diabetic-controls
#9
Bernardina T Fokkens, Douwe J Mulder, Casper G Schalkwijk, Jean L Scheijen, Andries J Smit, Leonoor I Los
PURPOSE: Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy. METHODS: We examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy...
2017: PloS One
https://www.readbyqxmd.com/read/28259964/effect-of-chloride-channel-activity-on-retinal-pigment-cell-proliferation-and-migration
#10
Jing Zhao, Wei Zhong, Lixia Sun, Yuan Yin, Yajuan Zheng
The present study aimed to investigate the effects of chloride channels (ClC) on the proliferation and migration of retinal pigment epithelial (RPE) cells, a primary component of proliferative vitreoretinopathy (PVR) membranes. An RPE cell model of phagocytosis was established using fibronectin‑coated latex beads. Cell proliferation was measured by live cell counting. The cell cycle and phagocytosis index was assessed by flow cytometry. Intracellular calcium concentration was quantified using Fura‑2‑acetoxymethyl ester...
February 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28252047/inhibition-of-proliferation-and-epithelial-mesenchymal-transition-in-retinal-pigment-epithelial-cells-by-heavy-chain-hyaluronan-pentraxin-3
#11
Hua He, Ajay E Kuriyan, Chen-Wei Su, Megha Mahabole, Yuan Zhang, Ying-Ting Zhu, Harry W Flynn, Jean-Marie Parel, Scheffer C G Tseng
Proliferative vitreoretinopathy (PVR) is mediated by proliferation and epithelial mesenchymal transition (EMT) of retinal pigment epithelium (RPE). Because heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) purified from human amniotic membrane exerts anti-inflammatory and anti-scarring actions, we hypothesized that HC-HA/PTX3 could inhibit these PVR-related processes in vitro. In this study, we first optimized an ARPE-19 cell culture model to mimic PVR by defining cell density, growth factors, and cultivation time...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28248989/efficacy-of-two-different-thiol-modified-crosslinked-hyaluronate-formulations-as-vitreous-replacement-compared-to-silicone-oil-in-a-model-of-retinal-detachment
#12
Sven Schnichels, Nele Schneider, Christine Hohenadl, José Hurst, Andreas Schatz, Kai Januschowski, Martin S Spitzer
The efficacy of two novel artificial vitreous body substitutes (VBS) consisting of highly biocompatible thiolated cross-linked hyaluronic acid (HA)-based hydrogels in comparison to silicone oil in a model of retinal detachment was investigated. Pars plana vitrectomy (23G) was performed in the right eye of 24 pigmented rabbits. Retinal detachment of two quadrants was induced by creating a small retinotomy near the vascular arcade and injecting balanced salt solution (BSS) subretinally. The retina was reattached by injecting air, which was followed by increasing the infusion pressure, and the retinal tear was treated by endolaser photocoagulation...
2017: PloS One
https://www.readbyqxmd.com/read/28237428/slow-release-dexamethasone-in-proliferative-vitreoretinopathy-a-prospective-randomized-controlled-clinical-trial
#13
Philip J Banerjee, Ana Quartilho, Catey Bunce, Wen Xing, Tapiwa M Zvobgo, Nicola Harris, David G Charteris
PURPOSE: To test the hypothesis that adjunctive slow-release dexamethasone implant (Ozurdex; Allergan Inc, Irvine, CA) can improve the outcomes of vitreoretinal surgery for established proliferative vitreoretinopathy (PVR). DESIGN: A 2-year, single-center, prospective, participant- and surgeon-masked randomized controlled clinical trial (EudraCT No. 2011-004498-96). PARTICIPANTS: A total of 140 patients requiring vitrectomy surgery with silicone oil for retinal detachment with established PVR (Grade C) were randomized to standard (control) or study treatment (adjunct) in a 1:1 allocation ratio...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28225198/adjunctive-steroid-therapy-versus-antibiotics-alone-for-acute-endophthalmitis-after-intraocular-procedure
#14
REVIEW
Carole H Kim, Monica F Chen, Anne L Coleman
BACKGROUND: Endophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and threatens vision. Most cases of endophthalmitis are exogenous (i.e. due to inoculation of organisms from an outside source), and most exogenous endophthalmitis is acute and occurs after an intraocular procedure. The mainstay of treatment is emergent administration of broad-spectrum intravitreous antibiotics. Due to their anti-inflammatory effects, steroids in conjunction with antibiotics have been proposed to be beneficial in endophthalmitis management...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28196061/therapeutic-outcomes-after-endoresection-of-complex-retinal-capillary-hemangioblastoma
#15
Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas, Mehmet Giray Ersoz, Serra Arf
PURPOSE: To evaluate the anatomical and functional outcomes after endoresection of complex retinal capillary hemangioblastoma (RCH). METHODS: Retrospective case series of 12 patients (13 eyes), all treated with pars plana vitrectomy, endodiathermy of feeding and draining vessels, endoresection of RCH and silicone oil injection. RESULTS: The mean age at the time of surgery was 32.5 ± 15.9 years. The mean follow-up duration after initial surgery was 50...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195617/pediatric-traumatic-retinal-detachments-clinical-characteristics-and-outcomes
#16
Sabahattin Sul, Gökhan Gurelik, Safak Korkmaz, Sengül Ozdek, Berati Hasanreisoglu
BACKGROUND AND OBJECTIVE: To compare clinical characteristics and surgical outcomes of retinal detachment (RD) after open globe injuries (OGIs) and closed globe injuries (CGIs). PATIENTS AND METHODS: One hundred ten eyes of 110 patients aged 17 years or younger who underwent primary RD repair after OGI and CGI between 2010 and 2013 were reviewed retrospectively. RESULTS: Cataract (59.8% vs. 21.7%; P = .002) and vitreous hemorrhage (54% vs...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28163930/surgical-management-of-traumatic-retinal-detachment-with-primary-vitrectomy-in-adult-patients
#17
Katarzyna Nowomiejska, Tomasz Choragiewicz, Dorota Borowicz, Agnieszka Brzozowska, Joanna Moneta-Wielgos, Ryszard Maciejewski, Anselm G Jünemann, Robert Rejdak
Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acuity, and presence of intraocular foreign body (IOFB) and proliferative vitreoretinopathy (PVR) were included in the analysis. Results. Mean age of patients was 47 years; the majority of patients were men (88%)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28160248/gas-tamponade-for-retinectomy-in-pvr-related-retinal-detachments-a-retrospective-study
#18
Vasileios T Papastavrou, Irini Chatziralli, Dominic McHugh
INTRODUCTION: The purpose of the study was to evaluate the anatomical and functional results in patients with proliferative vitreoretinopathy (PVR) treated with retinectomy and perfluoro-octane gas (C3F8) as a tamponade agent. METHODS: 12 patients with inferior and anterior complicated PVR-related retinal detachment, who were treated with retinectomy, where C3F8 was used as the tamponade agent were examined. Primary outcome was the anatomical success, while visual acuity, existence of an epiretinal membrane (ERM) and intraocular pressure (IOP) postoperatively were secondary outcomes...
February 3, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28157410/short-term-vitreoretinal-tamponade-with-heavy-liquid-following-surgery-for-giant-retinal-tear
#19
Maya Eiger-Moscovich, Assaf Gershoni, Ruth Axer-Siegel, Dov Weinberger, Rita Ehrlich
PURPOSE: To study the efficacy and outcomes of short-term postoperative vitreoretinal tamponade with perfluorocarbon heavy liquid in patients with giant retinal tear. MATERIALS AND METHODS: The study group consisted of 13 consecutive patients (13 eyes) who presented with giant retinal tear at a tertiary medical center in 2011-2015 and were treated with vitrectomy followed by short-term tamponade with perfluorocarbon heavy liquid. A minimum of 3 months' follow-up was required for inclusion...
February 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28147403/intraocular-dexamethasone-implant-as-adjunct-to-silicone-oil-tamponade-for-proliferative-vitreoretinopathy
#20
M Sherif, T J Wolfensberger
Background Proliferative vitreoretinopathy (PVR) occurs in 10 % of patients with retinal detachment and is characterized by excessive epi-, sub- or intraretinal contraction. Corticosteroids have been shown to counter this contraction. Patients and Methods Retrospective review of 5 patients (3 females, 2 males) with recurrent retinal detachment with stage C PVR. The mean age was 61.2 ± 20.5 years and myopia > - 5.0 dioptres was present in 3 eyes. Patients were treated with 23 g vitrectomy, retinectomy and endolaser, dexamethasone (Ozurdex®) injection under perfluorocarbone and 5500 cs silicone oil tamponade...
February 1, 2017: Klinische Monatsblätter Für Augenheilkunde
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