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Proliferative vitreoretinopathy

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https://www.readbyqxmd.com/read/28815590/juxtanodin-in-retinal-pigment-epithelial-cells-expression-and-biological-activities-in-regulating-cell-morphology-and-actin-cytoskeleton-organization
#1
Fengyi Liang, Ji Hyun Hwang, Nicholas Weiwei Tang, Walter Hunziker
Juxtanodin (also known as ermin) was initially identified as an actin cytoskeleton-related oligodendroglial protein in the rat central nervous system. It was subsequently also found in the rat olfactory neuroepithelium, especially at the apical junctional belt of the sustentacular cells. We further examined juxtanodin expression and functional roles in the retina using fluorescence histochemistry, confocal microscopy, immuno-electron microscopy, molecular biology and cell culture. Prominent juxtanodin expression was found in the photoreceptor-supporting retinal pigment epithelium (RPE), especially in a zone corresponding to the apices of RPE cells, at the roots of the RPE microvilli, and at the base of RPE cells next to the Bruch's membrane...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28807798/clinically-undetected-retinal-breaks-causing-retinal-detachment-options-for-management
#2
REVIEW
Deepak Gupta, Jared Ching, Paul E Tornambe
The successful detection of retinal breaks is a critical step in rhegmatogenous retinal detachment (RRD) surgery in order to prevent persistent/recurrent RRDs. Not all retinal breaks causing retinal detachments are obvious. Retinal breaks may be obscured due to opacities that are either anterior-segment related, lens related or posterior-segment related. Rules to identify breaks based on sub-retinal fluid (SRF) configuration are more difficult to apply in pseudophakic, aphakic, encircled eyes, and eyes with repeat detachments and those with proliferative vitreoretinopathy (PVR)...
August 11, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28807717/myofibroblast-transdifferentiation-the-dark-force-in-ocular-wound-healing-and-fibrosis
#3
REVIEW
Daisy Y Shu, Frank J Lovicu
Wound healing is one of the most complex biological processes to occur in life. Repair of tissue following injury involves dynamic interactions between multiple cell types, growth factors, inflammatory mediators and components of the extracellular matrix (ECM). Aberrant and uncontrolled wound healing leads to a non-functional mass of fibrotic tissue. In the eye, fibrotic disease disrupts the normally transparent ocular tissues resulting in irreversible loss of vision. A common feature in fibrotic eye disease is the transdifferentiation of cells into myofibroblasts that can occur through a process known as epithelial-mesenchymal transition (EMT)...
August 12, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28796867/subretinal-proliferative-vitreoretinopathy-band-with-apparent-splitting-of-the-photoreceptor-segments
#4
Ismini Koulouri, Patrick Oellers, Demetrios G Vavvas
No abstract text is available yet for this article.
August 10, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28781956/the-proteomic-profile-of-a-mouse-model-of-proliferative-vitreoretinopathy
#5
Bernadett Márkus, Zsuzsanna Pató, Zsolt Sarang, Réka Albert, József Tőzsér, Goran Petrovski, Éva Csősz
Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for PVR. A previously established mouse model, using dispase injection, was analyzed from the proteomic point of view, examining global protein profile changes by 2D electrophoresis, image analysis and HPLC-tandem mass spectrometry-based protein identification...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28777835/effect-of-methotrexate-on-an-in-vitro-patient-derived-model-of-proliferative-vitreoretinopathy
#6
Dhanesh Amarnani, Arturo Israel Machuca-Parra, Lindsay L Wong, Christina K Marko, James A Stefater, Tomasz P Stryjewski, Dean Eliott, Joseph F Arboleda-Velasquez, Leo A Kim
Purpose: The purpose of this study was to develop a method for isolating, culturing, and characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) to be used for drug testing. Methods: PVR membranes were obtained from six patients with grade C PVR. Membrane fragments were analyzed by gross evaluation, fixed for immunohistologic studies to establish cell identity, or digested with collagenase II to obtain single cell suspensions for culture...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28776588/outcome-of-surgery-in-patients-with-giant-retinal-tear-10-years-experience
#7
K Ghasemi Falavarjani, S A Alemzadeh, M Modarres, S A Alemzadeh, M M Parvarash, M Naseripour, M Hashemi, M Robatmeili
PurposeTo present our experience with the surgery in retinal detachment (RD) associated with giant retinal tear (GRT) over 10 years in a tertiary referral hospital.Patients and MethodsIn this retrospective study, the charts of all patients with the diagnosis of RD associated with GRT who underwent surgery from 2005 to 2015 at Rassoul Akram Hospital were reviewed. Exclusion criteria were concomitant presence of diabetic retinopathy, and uveitis. All patients had to have at least 3 months of follow up. The success rate and factors associated with repeated surgery were determined...
August 4, 2017: Eye
https://www.readbyqxmd.com/read/28770107/key-factors-to-improve-the-outcome-of-retinal-reattachment-surgery-in-proliferative-vitreoretinopathy-and-proliferative-diabetic-retinopathy
#8
Svenja Deuchler, Hanns Ackermann, Pankaj Singh, Thomas Kohnen, Clemens Wagner, Frank Koch
INTRODUCTION: For management of complicated retinal detachments, a pars plana vitrectomy with temporary silicone oil (SO) fill is the method of choice. According to literature, the retinal redetachment rate varies between <10% and >70% with around 36% in our own group (retrospective data analysis, n = 119 eyes). METHODS: The main goal was to reduce the retinal redetachment rate. Standard operating procedures (SOPs) and evaluation protocols (EVALPs) were developed to prospectively analyse risk factors...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28752694/impact-of-age-on-scleral-buckling-surgery-for-rhegmatogenous-retinal-detachment
#9
Sung Who Park, Han Jo Kwon, Ik Soo Byon, Ji Eun Lee, Boo Sup Oum
PURPOSE: The purpose of this study is to investigate new prognostic factors in associated with primary anatomical failure after scleral buckling (SB) for uncomplicated rhegmatogenous retinal detachment (RRD). METHODS: The medical records of patients with uncomplicated RRD treated with SB were retrospectively reviewed. Eyes with known prognostic factors for RRD, such as fovea-on, proliferative vitreoretinopathy, pseudophakia, aphakia, multiple breaks, or media opacity, were excluded...
August 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28745657/-surgical-treatment-of-rhegmatogenous-retinal-detachments-with-high-risk-of-proliferative-vitreoretinopathy
#10
L A Akhundova, E M Kasimov
AIM: to analyze the effect of internal limiting membrane (ILM) peeling in patients undergoing 23-gauge pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD) with a high risk of proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS: This was a prospective consecutive study of 231 eyes of 227 patients. All eyes underwent vitrectomy with silicone oil/gas tamponade for RRD with a high risk of PVR: in 42 eyes the ILM was peeled (group 1) and in the remaining 189 eyes - was not (group 2)...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28731053/oct-angiography-documented-reperfusion-of-translocated-autologous-full-thickness-rpe-choroid-graft-for-complicated-neovascular-age-related-macular-degeneration
#11
M Veckeneer, C Augustinus, E Feron, P-P Schauwvlieghe, J Ruys, I Cosemans, J Van Meurs
PurposeThe purpose of this study is to investigate the reperfusion of translocated retinal pigment epithelium (RPE)-choroid graft in the treatment of patients with neovascular age-related macular degeneration (nAMD), using OCT angiography (OCTA), a novel non-invasive, high-resolution imaging modality.Patients and methodsEighteen eyes of 18 consecutive patients suffering from complicated nAMD underwent RPE-choroid patch graft translocation surgery using a peripheral retinotomy and flap-over technique. We analyzed functional and anatomical outcome using visual acuity, Spectral Domain OCT and OCTA...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28723847/blindness-related-to-presumed-retinal-toxicity-after-using-perfluorocarbon-liquid-during-vitreoretinal-surgery
#12
Silvia Méndez-Martínez, Pilar Calvo, Nelson Arturo Rodriguez-Marco, Fernando Faus, Emilio Abecia, Luis Pablo
PURPOSE: To describe the presumed retinal toxicity after using specific batches of perfluorocarbon liquid ALA OCTA (Alamedics, Dornstadt, Germany) in pars plana vitrectomy. METHODS: This is an observational retrospective consecutive case series analyses of patients operated on pars plana vitrectomy for retinal detachment or intraocular lens subluxation, using the 150141 or 200114 batches of perfluorocarbon liquid ALA OCTA as assistance during the surgery in a single center...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28719670/suppressive-effect-of-amp-activated-protein-kinase-on-the-epithelial-mesenchymal-transition-in-retinal-pigment-epithelial-cells
#13
Ryo Matoba, Yuki Morizane, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Ryoichi Araki, Mika Hosogi, Tomoko Yonezawa, Fumio Shiraga
The epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a central role in the development of proliferative vitreoretinopathy (PVR). The purpose of this study was to investigate the effect of AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis, on the EMT in RPE cells. In this study, EMT-associated formation of cellular aggregates was induced by co-stimulation of cultured ARPE-19 cells with tumor necrosis factor (TNF)-α (10 ng/ml) and transforming growth factor (TGF)-β2 (5 ng/ml)...
2017: PloS One
https://www.readbyqxmd.com/read/28715581/incidence-and-factors-influencing-retinal-displacement-in-eyes-treated-for-rhegmatogenous-retinal-detachment-with-vitrectomy-and-gas-or-silicone-oil
#14
MULTICENTER STUDY
Roberto dell'Omo, Andrea Scupola, Davide Viggiano, Maria Grazia Sammarco, Serena De Turris, Mario R Romano, Gabriela Grimaldi, Ermanno dell'Omo, Ciro Costagliola
Purpose: The purpose of this study was to study the incidence and factors influencing retinal displacement in eyes treated for rhegmatogenous retinal detachment (RRD) with pars plana vitrectomy (PPV) and gas or silicone oil. Methods: This was a prospective observational case series. One hundred twenty-five eyes with macula-off RRD from 125 patients underwent 25-gauge PPV at two vitreoretinal institutional practices. Eyes without proliferative vitreoretinopathy (PVR) or PVR grade A were tamponated with sulfur hexafluoride (SF6) gas, whereas eyes with PVR grade B received 1000 centistokes silicone oil (SO)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28706757/biological-involvement-of-micrornas-in-proliferative-vitreoretinopathy
#15
REVIEW
Hiroki Kaneko, Hiroko Terasaki
Even with a high surgical success rate for retinal detachment and proliferative vitreoretinopathy (PVR) supported by the robust improvement in vitrectomy surgery and its related devices, certain questions still remain for the pathogenesis and treatment of PVR. One of the important biological events in PVR is epithelial-mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells. MicroRNAs are noncoding, small, single-strand RNAs that posttranscriptionally regulate gene expression and have essential roles in homeostasis and pathogenesis in many diseases...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28674834/intraocular-silicone-implant-to-treat-chronic-ocular-hypotony-an-in-vivo-trial
#16
Wesal Bayoudh, Dörthe Carstesen, Peter Walter, Andreas W A Weinberger
PURPOSE: The management of chronic ocular hypotony and complicated proliferative vitreoretinopathy-related retinal detachment represents a challenge. Being non-absorbable and non-biodegradable, a silicone oil implant is expected to restore the volume and the intraocular pressure of the globe, as well as to approximate the detached retina. Further advantages could be a long-term tamponade potential, absence of toxicity, and prevention of silicone oil emulsification or anterior chamber oil-prolapse...
July 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28645275/rapid-monocyte-infiltration-following-retinal-detachment-is-dependent-on-non-canonical-il6-signaling-through-gp130
#17
Xinlei Wang, Eric B Miller, Mayank Goswami, Pengfei Zhang, Kaitryn E Ronning, Sarah J Karlen, Robert J Zawadzki, Edward N Pugh, Marie E Burns
BACKGROUND: Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL6, but little is known about the source and downstream signaling of IL6 and the consequences for the retina. Here, we investigated the early immune response and resultant cytokine signaling following RD in mice. METHODS: RD was induced in C57BL/6 J and IL6 knockout mice, and the resulting inflammatory response was examined using immunohistochemistry and flow cytometry...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28639085/nonsteroid-anti-inflammatory-therapy-suppresses-the-development-of-proliferative-vitreoretinopathy-more-effectively-than-a-steroid-one
#18
Marina V Tikhonovich, Aleksei K Erdiakov, Svetlana A Gavrilova
PURPOSE: This study proves the possibility of targeted use of the nonsteroidal anti-inflammatory drug lornoxicam to prevent the development of proliferative vitreoretinopathy (PVR). Triamcinolone acetonide (TA) was selected as a reference substance. METHODS: Wistar rats (N = 400) were used. PVR was modeled by intravitreal injection of dispase or concanavalin A. Lornoxicam or TA intravitreal administration was performed 20 min later. On the second and the third day, drugs were administrated systemic...
June 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28635048/prophylactic-chorioretinectomy-for-eye-injuries-with-high-proliferative-vitreoretinopathy-risk
#19
Ferenc Kuhn, Wolfgang Schrader
With its incidence exceeding 60%, proliferative vitreoretinopathy (PVR) remains the most important pathology responsible for loss of vision, even the eyeball, after certain types of severe trauma. In this article, we present results obtained using our novel surgical technique, prophylactic chorioretinectomy (PCR), to prevent the development of PVR. Data on severely injured eyes at high risk for PVR [rupture, posterior laceration, deep-impact intraocular foreign body (IOFB) trauma, perforating injury] were collected prospectively...
June 21, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28634054/effect-of-endothelin-1-on-proliferation-migration-and-fibrogenic-gene-expression-in-human-rpe-cells
#20
Dong Qin, Li Zhang, Xuemin Jin, Zhaoxia Zhao, Yanrong Jiang, Zijun Meng
The pathology of the fibrotic proliferative vitreoretinopathy (PVR) membrane represents an excessive wound healing response characterised by cells' proliferation, migration and secretion of extracellular matrix molecules (ECMs). Retinal pigment epithelial (RPE) cells are a major cellular component of the fibrotic membrane. Endothelin-1 (ET-1) has been reported to be involved in the development of PVR in vivo research. However, little is known about the role of ET-1 in RPE cells in vitro. In the present study, we investigated the role of ET-1 in the proliferation, migration and secretion of ECMs (such as type I collagen and fibronectin) in RPE cells in vitro...
June 17, 2017: Peptides
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