Runzhu Shi, Marius Reichardt, Dominik J Fiegle, Linda K Küpfer, Titus Czajka, Zhengwu Sun, Tim Salditt, Andreas Dendorfer, Thomas Seidel, Tobias Bruegmann
AIMS: Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches are required to predict cardiotoxicity with high specificity and sensitivity. Ideally, such methods should be performed within intact cardiac tissue with high relevance for humans and detect acute and chronic side effects on electrophysiological behaviour, contractility, and tissue structure in an unbiased manner. Herein, we evaluate healthy pig myocardial slices and biomimetic cultivation setups (BMCS) as a new cardiotoxicity screening approach...
November 2, 2023: Cardiovascular Research