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https://www.readbyqxmd.com/read/29166307/comment-thoracoacromial-vessels-exposure-in-microvascular-breast-reconstruction
#1
Benoit Ayestaray, Theodoros Chrelias
No abstract text is available yet for this article.
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29165935/peripapillary-perfused-capillary-density-in-exfoliation-syndrome-and-exfoliation-glaucoma-versus-poag-and-healthy-controls-an-octa-study
#2
Yanin Suwan, Lawrence S Geyman, Masoud Aghsaei Fard, Apichat Tantraworasin, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. DESIGN: Observational, cross-sectional study. METHODS: Optical coherence tomography angiography (OCTA) images (4.5×4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA)...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165672/trans-sylvian-approach-to-microvascular-decompression-for-trigeminal-neuralgia-in-syndromic-cranial-base-settling
#3
Mrityunjoy Sarkar, Ashok Pillai
BACKGROUND AND IMPORTANCE: The lateral suboccipital approach for microvascular decompression (MVD) of the trigeminal nerve has become a standard-of-care over the past several decades. Syndromic cranial base settling, a rare but known cause for trigeminal neuralgia (TN), poses significant dilemmas in clinical management. In such cases, distorted anatomy may render surgery via the suboccipital approach difficult or even impossible. CLINICAL PRESENTATION: A 34-yr-old male with osteogenesis imperfecta and severe basilar invagination suffered from TN that was refractory to medication and stereotactic radiosurgery...
November 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29165016/the-use-of-osteochondral-flaps-in-the-treatment-of-carpal-disorders
#4
James P Higgins, Heinz K Bürger
Vascularized osteochondral flaps have been described for use in reconstruction of the wrist, providing the benefits of osteochondral grafts in addition to the benefit of osseous and subchondral perfusion via the microvascular pedicle. Various harvest sites have been described including the medial and lateral femoral trochlea and the proximal third metatarsal. The reconstructed surfaces described include the cartilage surfaces of the scaphoid, lunate, capitate and radius. The ability to transfer analogous osteochondral surfaces poses the possibility for new motion-preserving alternatives for difficult articular problems previously treated with salvage procedures...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29164596/regulation-of-t-helper-cell-responses-during-antigen-presentation-by-norepinephrine-exposed-endothelial-cells
#5
Linghui Xu, Wanhong Ding, Lori L Stohl, Xi K Zhou, Shayan Azizi, Ethan Chuang, Jimmy Lam, John A Wagner, Richard D Granstein
Dermal blood vessels and regional lymph nodes are innervated by sympathetic nerves and, under stress, sympathetic nerves release norepinephrine (NE). Exposure of primary murine dermal microvascular endothelial cells (pDMECs) to NE followed by co-culture with Langerhans cells (LCs), responsive CD4(+) T cells and antigen resulted in modulation of CD4(+) T cell responses. NE-treatment of pDMECs induced increased production of interleukin (IL)-6 and IL-17A while downregulating interferon (IFN)-γ and IL-22 release...
November 21, 2017: Immunology
https://www.readbyqxmd.com/read/29164413/comparison-of-recurrence-between-pancreatic-and-duodenal-neuroendocrine-neoplasms%C3%A2-after-curative-resection-a-single-institution-analysis
#6
Toshihiko Masui, Asahi Sato, Kenzo Nakano, Yuichiro Uchida, Akitada Yogo, Takayuki Anazawa, Kazuyuki Nagai, Yoshiya Kawaguchi, Kyoichi Takaori, Shinji Uemoto
BACKGROUND: The primary site of a neuroendocrine neoplasms (NEN) around the head of the pancreas is sometimes difficult to assess before resection, and the characteristics of the primary site around this region have not been elucidated for recurrence after curative resection. In this study, the clinicopathologic characteristics of pancreatic NEN (PanNEN) and duodenal NEN (DuNEN) were evaluated, and the risk factors as well as the recurrence types after resection were investigated. METHODS: Consecutively diagnosed NEN patients at the authors' hospital from January 2000 to July 2016 were evaluated in this study...
November 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29163190/sr-bi-mediated-transcytosis-of-hdl-in-brain-microvascular-endothelial-cells-is-independent-of-caveolin-clathrin-and-pdzk1
#7
Karen Y Fung, Changsen Wang, Steffen Nyegaard, Bryan Heit, Gregory D Fairn, Warren L Lee
The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation. Using a combination of spinning-disc confocal and total internal reflection fluorescence microscopy, we examined the uptake and transcytosis of HDL by human primary brain microvascular endothelial cell monolayers...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162596/lactadherin-promotes-microvesicle-clearance-to-prevent-coagulopathy-and-improves-survival-of-severe-tbi-mice
#8
Yuan Zhou, Wei Cai, Zilong Zhao, Tristan Hilton, Min Wang, Jason Yeon, Wei Liu, Fangyi Zhang, Fu-Dong Shi, Xiaoping Wu, Perumal Thiagarajan, Min Li, Jianning Zhang, Jing-Fei Dong
Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 µg/kg 30 min before (preconditioning) or 30 min after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs...
November 21, 2017: Blood
https://www.readbyqxmd.com/read/29162583/international-consensus-on-use-of-continuous-glucose-monitoring
#9
REVIEW
Thomas Danne, Revital Nimri, Tadej Battelino, Richard M Bergenstal, Kelly L Close, J Hans DeVries, Satish Garg, Lutz Heinemann, Irl Hirsch, Stephanie A Amiel, Roy Beck, Emanuele Bosi, Bruce Buckingham, Claudio Cobelli, Eyal Dassau, Francis J Doyle, Simon Heller, Roman Hovorka, Weiping Jia, Tim Jones, Olga Kordonouri, Boris Kovatchev, Aaron Kowalski, Lori Laffel, David Maahs, Helen R Murphy, Kirsten Nørgaard, Christopher G Parkin, Eric Renard, Banshi Saboo, Mauro Scharf, William V Tamborlane, Stuart A Weinzimer, Moshe Phillip
Measurement of glycated hemoglobin (HbA1c) has been the traditional method for assessing glycemic control. However, it does not reflect intra- and interday glycemic excursions that may lead to acute events (such as hypoglycemia) or postprandial hyperglycemia, which have been linked to both microvascular and macrovascular complications. Continuous glucose monitoring (CGM), either from real-time use (rtCGM) or intermittently viewed (iCGM), addresses many of the limitations inherent in HbA1c testing and self-monitoring of blood glucose...
December 2017: Diabetes Care
https://www.readbyqxmd.com/read/29162432/renal-damage-in-the-metabolic-syndrome-metsx-disorders-implicated
#10
REVIEW
Trujillo Joyce, Chirino Yolanda Irasema, Martínez-Tagüeña Natalia, Pedraza-Chaverri Jose
The prevalence of metabolic syndrome is increasing worldwide and has become a risk factor for the development of chronic kidney disease. The complex linkage between metabolic syndrome and chronic kidney disease is under research and the factors involved beyond the biological pathogenesis include demographic, sociological and psychological factors that are related to the metabolic syndrome prevalence. The social context of disease causation is as relevant to today's clinical scientist and practitioner as biomarker-directed risk stratification and therapy...
November 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29161807/intravenous-dextran-70-infusion-has-protective-effects-on-ischemia-reperfusion-injury-of-kidney-an-experimental-study
#11
Atilla Semercioz, Mustafa Z Temiz, Ipek Erbarut, Ugur Izol, Serdar Aykan, Murat Tuken, Engin Kandirali
BACKGROUND: Renal ischemia-reperfusion (IR) leads to alterations of tubular epithelial cells, interstitial microvasculopathy and endothelial cell dysfunction in peritubular capillaries. Although dextrans have deteriorative effects on healthy kidney, their favorable effects on post-ischemic microvascular disturbances have been demonstrated. Therefore, we aimed to investigate in vivo effects of systemic Dextran 70 administration in kidney tissue with ischemia-reperfusion injury. METHODS: Twenty-one rats were allocated as sham, IR and IR+ Dextran 70 treatment groups...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29161767/effects-of-different-endurance-exercise-modalities-on-migraine-days-and-cerebrovascular-health-in-episodic-migraineurs-a-randomized-controlled-trial
#12
Henner Hanssen, Alice Minghetti, Stefano Magon, Anja Rossmeissl, Maria Rasenack, Athina Papadopoulou, Christopher Klenk, Oliver Faude, Lukas Zahner, Till Sprenger, Lars Donath
BACKGROUND: Aerobic exercise training is a promising complementary treatment option in migraine and can reduce migraine days and improve retinal microvascular function. Our aim was to elucidate whether different aerobic exercise programs at high vs. moderate intensities distinctly affect migraine days as primary outcome and retinal vessel parameters as a secondary. METHODS: In this randomized controlled trial, migraine days were recorded by a validated migraine diary in 45 migraineurs of which 36 (female: 28; age: 36 (SD:10)/ BMI: 23...
November 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29160952/transit-time-mapping-in-the-mouse-brain-using-time-encoded-pcasl
#13
Lydiane Hirschler, Leon P Munting, Artem Khmelinskii, Wouter M Teeuwisse, Ernst Suidgeest, Jan M Warnking, Louise van der Weerd, Emmanuel L Barbier, Matthias J P van Osch
The cerebral blood flow (CBF) is a potential biomarker for neurological disease. However, the arterial transit time (ATT) of the labeled blood is known to potentially affect CBF quantification. Furthermore, ATT could be an interesting biomarker in itself, as it may reflect underlying macro- and microvascular pathologies. Currently, no optimized magnetic resonance imaging (MRI) sequence exists to measure ATT in mice. Recently, time-encoded labeling schemes have been implemented in rats and humans, enabling ATT mapping with higher signal-to-noise ratio (SNR) and shorter scan time than multi-delay arterial spin labeling (ASL)...
November 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29160087/glyoxalase-1-modulation-in-obesity-and-diabetes
#14
Naila Rabbani, Paul J Thornalley
SIGNIFICANCE: Obesity and type 2 diabetes mellitus are increasing globally. There is also increasing associated complications, such as non-alcoholic fatty liver disease (NAFLD) and vascular complications of diabetes. There is currently no licensed treatment for NAFLD and no recent treatments for diabetic complications. New approaches are required, particularly addressing mechanism-based risk factors for health decline and disease progression. Recent advances: Dicarbonyl stress is the abnormal accumulation of reactive dicarbonyl metabolites such as methylglyoxal leading to cell and tissue dysfunction...
November 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29158223/tgf-%C3%AE-induces-oncofetal-fibronectin-which-in-turn-modulates-tgf-%C3%AE-superfamily-signaling-in-endothelial-cells
#15
Elisa Ventura, Michael Weller, Will Macnair, Katja Eschbach, Christian Beisel, Cinzia Cordazzo, Manfred Claassen, Luciano Zardi, Isabel Burghardt
Gene splicing profiles are frequently altered in cancer, and the splice variants of fibronectin (FN) containing the extra-domains A (EDA) and B (EDB) referred to as EDA+FN and EDB+FN are highly up-regulated in tumor vasculature. TGF-β signaling has been attributed a pivotal role in glioblastoma, with TGF-β promoting angiogenesis and vessel remodeling. By immunohistochemical staining, we observed that the oncofetal FN isoforms EDA+FN and EDB+FN are expressed in glioblastoma vasculature. Ex vivo single cell gene expression profiling of patients' tumors using the markers CD31 and alpha-smooth muscle actin (αSMA) respectively confirmed the predominant expression of FN, EDA+FN, and EDB+FN in the vascular compartment of glioblastoma...
November 20, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29158153/m3-receptor-is-involved-in-the-effect-of-penehyclidine-hydrochloride-reduced-endothelial-injury-in-lps-stimulated-human-pulmonary-microvascular-endothelial-cell
#16
Qinghong Yuan, Fei Xiao, Qiangsheng Liu, Fei Zheng, Shiwen Shen, Qianwen He, Kai Chen, Yanlin Wang, Zongze Zhang, Jia Zhan
LPS has been recently shown to induce muscarinic acetylcholine 3 receptor (M3 receptor) expression and penehyclidine hydrochloride (PHC) is an anticholinergic drug which could block the expression of M3 receptor. PHC has been demonstrated to perform protective effect on cell injury. This study is to investigate whether the effect of PHC on microvascular endothelial injury is related to its inhibition of M3 receptor or not. HPMVECs were treated with specific M3 receptor shRNA or PBS, and randomly divided into LPS group (A group), LPS+PHC group (B group), LPS + M3 shRNA group (C group) and LPS + PHC + M3 shRNA group (D group)...
November 17, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29158091/observation-of-the-effects-of-different-surgical-treatments-on-unilateral-masticatory-muscle-spasm
#17
Guangyong Wu, Jia Ouyang, Zhiyu Zhang, Ruen Liu
BACKGROUND: Unilateral masticatory muscle spasm is a rare disease without a generally accepted and efficacious treatment plan. OBJECTIVE: To compare the effects of different surgical treatments on unilateral masticatory muscle spasm. METHODS: Retrospective analysis of the surgical treatment and effects of 10 cases of unilateral masticatory muscle spasm between February 2010 and September 2016. Three cases underwent complete amputation of the trigeminal motor branch, 3 cases underwent partial amputation of the trigeminal motor branch, and 4 cases received only vascular decompression...
November 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29157813/anti-inflammatory-and-antiviral-activities-of-cynanversicoside-a-and-cynanversicoside-c-isolated-from-cynanchun-paniculatum-in-influenza-a-virus-infected-mice-pulmonary-microvascular-endothelial-cells
#18
Panying Wei, Tao Zhang, Hong Dong, Qiaohong Chen, Xiang Mu, Ge Hu
BACKGROUND: Outbreaks of the influenza A virus (IAV) often occur in various avian and mammalian species, including humans, causing serious respiratory injury worldwide. Therapeutic actions are limited to vaccines and a few antiviral drugs. Combination antiviral compounds and anti-inflammatory modulators to control the propagation of viruses would be more efficient therapeutic strategies for infectious diseases. PURPOSE: This study was designed to isolate anti-inflammatory and antiviral compounds from Cynanchun paniculatum and elucidate their potential molecular mechanisms...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157809/the-regulatory-effect-of-oxymatrine-on-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-in-lipopolysaccharide-induced-ms1-cells
#19
Meili Lu, Qing Zhang, Kai Chen, Wei Xu, Xiaohui Xiang, Shihai Xia
BACKGROUND: Oxymatrine (OM), a major quinolizidine alkaloid extracted from the roots of Sophora flavescens, has been proved to regulate a variety of signaling pathways to produce a wide range of pharmacological effects. OBJECTIVES: The regulatory effects of OM on the TLR4/MyD88/NF-κB signaling pathway under the stimulation of lipopolysaccharide (LPS) in MS1 cells were explored to illuminate the potential anti-inflammatory mechanism of OM for pancreatitis treatment...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156770/sco-spondin-oligopeptide-inhibits-angiogenesis-in-glioblastoma
#20
Romain Bibes, Stéphane Gobron, François Vincent, Carole Mélin, Nicolas Vedrenne, Aurélie Perraud, Francois Labrousse, Marie-Odile Jauberteau, Fabrice Lalloué
Angiogenesis plays a critical role in glioblastoma growth and progression. We therefore aimed at evaluating the anti-angiogenic properties of an oligopeptide originating from SCO-spondin (NX) on a model of human glioblastoma. To this end, we studied the impact of NX treatment on human brain endothelial cells (HBMECs) alone or co-cultured with glioblastoma cells (U87-MG) on apoptosis, proliferation, migration and release of angiogenic factors. We further investigated the anti-angiogenic potential of NX on human glioblastoma cells grown on chorio-allantoic membrane (CAM) or in glioblastoma xenografts...
October 17, 2017: Oncotarget
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