keyword
https://read.qxmd.com/read/38530230/group-based-exercise-training-programs-for-military-members-presenting-musculoskeletal-disorders-a-pragmatic-randomized-controlled-trial
#21
JOURNAL ARTICLE
Frédérique Dupuis, Kadija Perreault, Luc J Hébert, Marc Perron, Anny Fredette, François Desmeules, Jean-Sébastien Roy
OBJECTIVE: To compare the effects of personalized supervised group-based programs (group physical therapy programs) to usual one-on-one physical therapy care (usual physical therapy care) on disability for military personnel suffering from low back pain, rotator cuff-related shoulder pain, patellofemoral pain syndrome or lateral ankle sprain. Secondary outcomes were pain severity, pain-related fear, health-related quality of life and patients' satisfaction with their condition and care. DESIGN: Non-inferiority pragmatic randomized clinical trial...
March 26, 2024: Journal of Orthopaedic and Sports Physical Therapy
https://read.qxmd.com/read/38529608/liposomal-nano-based-drug-delivery-systems-for-breast-cancer-therapy-recent-advances-and-progresses
#22
JOURNAL ARTICLE
Mostafa Yazdan, Seyed Morteza Naghib, M R Mozafari
Breast cancer is a highly prevalent disease on a global scale, with a 30% incidence rate among women and a 14% mortality rate. Developing countries bear a disproportionate share of the disease burden, while countries with greater technological advancements exhibit a higher incidence. A mere 7% of women under the age of 40 are diagnosed with breast cancer, and the prevalence of this ailment is significantly diminished among those aged 35 and younger. Chemotherapy, radiation therapy, and surgical intervention comprise the treatment protocol...
March 25, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38529411/novel-molecular-targets-in-endometrial-cancer-mechanisms-and-perspectives-for-therapy
#23
REVIEW
Pamela Soberanis Pina, Stephanie Lheureux
Endometrial cancer (EC) has a high epidemiological impact with incidence and mortality rising worldwide. In recent years, the integration of the pathologic and molecular classification has provided relevant information to understand the heterogeneity in the biology of EC, which led to the evolution in the management of patients. Currently, therapeutic breakthroughs have been made in advanced EC to improve oncologic outcomes, with efforts to include patient reported outcomes. Precision and personalized medicine are under way in EC exploring different combination approaches to target cross-talk pathways, cancer cell microenvironment, and metabolic vulnerabilities and improve drug delivery...
2024: Biologics: Targets & Therapy
https://read.qxmd.com/read/38529322/impact-of-hyperuricemia-and-urate-lowering-agents-on-cardiovascular-diseases
#24
REVIEW
Franklin Sosa, Mohammed Shaban, Jose Lopez, Gustavo J Duarte, Swati Jain, Asma Khizar, Timothy Vittorio, Rishabh Mishra, Miguel Rodriguez Guerra
The association between hyperuricemia and cardiovascular diseases has been studied for many years. Research has shown a link between high uric acid levels and increased risk of including coronary artery disease hypertension and other cardiovascular conditions. Urate-lowering therapy, particularly with xanthine oxidase inhibitors like allopurinol, has shown promising results in reducing blood pressure in individuals with hyperuricemia and hypertension. Clinical trials and studies have demonstrated significant reductions in both systolic and diastolic blood pressure with urate-lowering treatment...
2024: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/38529258/knowledge-and-awareness-of-osteoporosis-a-survey-of-physical-therapy-providers-in-saudi-arabia
#25
JOURNAL ARTICLE
Muataz Almaddah, Fahad Alzahrani, RiziqAllah Gaowgzeh, Abdullah Alqarni, Rani Othman, Afnan Gmmash
BACKGROUND: Osteoporosis "OP" is classified as one of the most serious health conditions worldwide. OP increases the skeletal fracture risk by 35%, particularly at hip, spine, and wrist joints. Healthcare professionals should be aware of OP clinical signs and have good knowledge while managing all patients. OBJECTIVES: This study aims to investigate the current level of osteoporosis knowledge and awareness among physical therapy providers in Saudi Arabia. METHODS: One hundred and sixty-eight physical therapy providers participated in this cross-sectional electronic survey from February to July of 2021...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38529115/recent-advances-in-the-therapeutic-management-of-calcium-pyrophosphate-deposition-disease
#26
REVIEW
Paraskevi V Voulgari, Aliki I Venetsanopoulou, Alexandros A Drosos
Calcium pyrophosphate deposition (CPPD) disease is a form of crystal-induced arthropathy that arises from the accumulation of calcium pyrophosphate crystals within joints and soft tissues. This process leads to inflammation and damage to the affected joints. It can present asymptomatically or as acute or chronic inflammatory arthritis. Risk factors and comorbidities, including prior joint injury, osteoarthritis, hereditary or familial predisposition, and metabolic diseases, should be evaluated in CPPD cases...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38528307/pathophysiology-diagnosis-and-herbal-medicine-based-therapeutic-implication-of-rheumatoid-arthritis-an-overview
#27
REVIEW
Charanjit Kaur, Yachana Mishra, Rajesh Kumar, Gurvinder Singh, Sukhraj Singh, Vijay Mishra, Murtaza M Tambuwala
Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4-1.3% of the global population, this condition poses significant challenges as current therapeutic approaches primarily offer symptomatic relief, with the prospect of complete recovery remaining elusive. This review delves into the contemporary advancements in understanding the pathophysiology, diagnosis, and the therapeutic potential of herbal medicine in managing RA...
March 25, 2024: Inflammopharmacology
https://read.qxmd.com/read/38526997/global-prevalence-mortality-and-main-characteristics-of-hiv-associated-pneumocystosis-a-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Ehsan Ahmadpour, Sevda Valilou, Mohammad Ali Ghanizadegan, Rouhollah Seyfi, Seyed Abdollah Hosseini, Kareem Hatam-Nahavandi, Hanieh Hosseini, Mahsa Behravan, Aleksandra Barac, Hamid Morovati
The epidemiology of Human Immunodeficiency Virus (HIV)-associated pneumocystosis (HAP) is poorly described on a worldwide scale. We searched related databases between January 2000 and December 2022 for studies reporting HAP. Meta-analysis was performed using StatsDirect (version 2.7.9) and STATA (version 17) according to the random-effects model for DerSimonian and Laird method and metan and metaprop commands, respectively. Twenty-nine studies with 38554 HIV-positive, 79893 HIV-negative, and 4044 HAP populations were included...
2024: PloS One
https://read.qxmd.com/read/38526855/genetic-determinants-of-taxane-induced-peripheral-neuropathy
#29
JOURNAL ARTICLE
Beata Mladosievicova, Magdalena Nemcokova Jablonicka, Lucia Tatayova, Michal Bernadic
The efficacy of taxane‑containing regimens has been demonstrated for various cancers, particularly ovarian, endometrial, breast, lung, and prostate cancers. However, extensive taxane-induced toxicities limit their use. Prediction and management of many toxic complications in cancer patients have evolved significantly over the last decade. Peripheral neuropathy is the most typical non-hematological taxane-related complication, and it has a multifactorial pathogenesis. It is often dose-dependent and progressive during therapy and sometimes even after treatment...
2024: Bratislavské Lekárske Listy
https://read.qxmd.com/read/38526818/therapeutic-effects-of-orally-administration-of-viable-and-inactivated-probiotic-strains-against-murine-urinary-tract-infection
#30
REVIEW
Vo Thi Hong Van, Zhen-Shu Liu, Yueh-Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen
Urinary tract infections (UTIs) are highly prevalent bacterial infections that pose significant health risks. Specific probiotic strains have been recommended for UTI control and management of antibiotic resistance. Otherwise, para-probiotics, defined as inactivated probiotic cells, offer potential advantages by minimizing risks associated with live microorganisms. However, the effectiveness of heat-killed probiotic strains against UTIs remains uncertain. Additionally, lactoferrin (LF), an iron-binding glycoprotein, exhibits immunomodulatory, antimicrobial, and anti-inflammatory properties...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526540/metastatic-colorectal-cancer-third-line-therapy-and-beyond
#31
REVIEW
Tiffany Foo, Amitesh Roy, Christos Karapetis, Amanda Townsend, Timothy Price
INTRODUCTION: The outcome of patients with metastatic colorectal cancer (mCRC) has improved significantly in the last few decades. Metastatic colorectal cancer is a highly heterogenous cancer. Beyond second line chemotherapy, treatment decisions are often based on molecular testing. METHOD: In this narrative review, we provide a comprehensive summary of data from key clinical trials and discuss how to integrate these agents into the current treatment landscape of metastatic colorectal cancer...
March 25, 2024: Expert Review of Anticancer Therapy
https://read.qxmd.com/read/38526024/home-participation-and-personal-and-environmental-factors-in-children-and-adolescents-with-down-syndrome
#32
JOURNAL ARTICLE
Beatriz Helena Brugnaro, Gesica Fernandes, Ana Carolina De Campos, Silvia Letícia Pavão, Luzia Iara Pfeifer, Olaf Kraus de Camargo, Oksana Hlyva, Nelci Adriana Cicuto Ferreira Rocha
AIM: To describe current home participation (frequency, involvement) and caregiver's desire for change in home participation of children and adolescents with Down syndrome, as well as home environmental factors, and to explore the associations of personal and environmental factors with current participation and caregiver's desire for change. METHOD: Eighty-two caregivers (mean age = 45 years 10 months) of children and adolescents with Down syndrome (mean age = 10 years 7 months) were surveyed about the child's home participation and environmental factors using the Participation and Environment Measure-Children and Youth...
March 25, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38525773/advancing-care-in-severe-asthma-the-art-of-switching-biologics
#33
REVIEW
Silvano Dragonieri, Andrea Portacci, Vitaliano Nicola Quaranta, Giovanna Elisiana Carpagnano
Biologics targeting IgE, IL-5, IL-4/IL-13, and TSLP are crucial in severe asthma treatment. Research, including randomized controlled trials and real-world studies, has been conducted to assess their efficacy and identify patient characteristics that may predict positive responses. The effectiveness of switching biologics, especially given overlaps in treatment eligibility, and the clinical outcomes post-cessation are critical areas of investigation. This work reviews the effects of switching between these biologics and the indicators of treatment success or failure...
February 21, 2024: Advances in Respiratory Medicine
https://read.qxmd.com/read/38525771/exploring-brain-and-heart-interactions-during-electroconvulsive-therapy-with-point-of-care-ultrasound
#34
JOURNAL ARTICLE
Marvin G Chang, Tracy A Barbour, Edward A Bittner
BACKGROUND: Electroconvulsive therapy (ECT) is a procedure commonly used to treat a number of severe psychiatric disorders, including pharmacologic refractory depression, mania, and catatonia by purposefully inducing a generalized seizure that results in significant hemodynamic changes as a result of an initial transient parasympathetic response that is followed by a marked sympathetic response from a surge in catecholamine release. While the physiologic response of ECT on classic hemodynamic parameters such as heart rate and blood pressure has been described in the literature, real-time visualization of cardiac function using point-of-care ultrasound (POCUS) during ECT has never been reported...
March 22, 2024: Medical Sciences: Open Access Journal
https://read.qxmd.com/read/38525751/pulmonary-diseases-in-older-patients-understanding-and-addressing-the-challenges
#35
JOURNAL ARTICLE
Pushpa Raj Joshi
As the global population ages, pulmonary diseases among older people have emerged as a significant and growing public health concern. The increasing incidence of these conditions has led to higher rates of morbidity and mortality among older adults. This perspective study offers a thorough overview of the prevalent pulmonary diseases affecting the elderly demographic. It delves into the challenges encountered during the diagnosis and management of these conditions in older individuals, considering factors such as comorbidities, functional limitations, and medication complexities...
March 7, 2024: Geriatrics
https://read.qxmd.com/read/38525718/tissue-based-genomic-testing-in-prostate-cancer-10-year-analysis-of-national-trends-on-the-use-of-prolaris-decipher-promark-and-oncotype-dx
#36
JOURNAL ARTICLE
Eugenio Bologna, Francesco Ditonno, Leslie Claire Licari, Antonio Franco, Celeste Manfredi, Spencer Mossack, Savio Domenico Pandolfo, Cosimo De Nunzio, Giuseppe Simone, Costantino Leonardo, Giorgio Franco
BACKGROUND: Prostate cancer (PCa) management is moving towards patient-tailored strategies. Advances in molecular and genetic profiling of tumor tissues, integrated with clinical risk assessments, provide deeper insights into disease aggressiveness. This study aims to offer a comprehensive overview of the pivotal genomic tests supporting PCa treatment decisions, analyzing-through real-world data-trends in their use and the growth of supporting literature evidence. METHODS: A retrospective analysis was conducted using the extensive PearlDiver™ Mariner database, which contains de-identified patient records, in compliance with the Health Insurance Portability and Accountability Act (HIPAA)...
March 19, 2024: Clinics and Practice
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#37
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38524770/impact-of-goal-directed-hemodynamic-therapy-on-perioperative-outcomes-in-head-and-neck-free-flap-surgery-a-before-and-after-pilot-study
#38
JOURNAL ARTICLE
Justine Philteos, Stuart A McCluskey, Sophia Emerson, George Djaiani, David Goldstein, Sabri Soussi
BACKGROUND: Free flap reconstruction for head and neck cancer is associated with a high risk of perioperative complications. One of the modifiable risk factors associated with perioperative morbidity is intraoperative hypotension (IOH). The main aim of this pilot study is to determine if the intraoperative use of goal-directed hemodynamic therapy (GDHT) is associated with a reduction in the number of IOH events in this population. METHODS: A before-and-after study design...
March 2024: Health Science Reports
https://read.qxmd.com/read/38524665/low-dose-pregabalin-improves-gastrointestinal-symptoms-of-crohn-s-disease
#39
Antonio Maria D'Onofrio, Federica Di Vincenzo, Gaspare Filippo Ferrajoli, Franco Scaldaferri, Giovanni Camardese
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are lifelong conditions with no definite cure. Several studies demonstrated that patients with IBD more frequently experience symptoms of common mental disorders, such as anxiety and depression, because of bidirectional communication through the gut-brain axis and the chronicity of symptoms, as well as because of impaired quality of life and reduced social functioning. However, psychological conditions of affected patients are often underestimated and not fully considered...
2024: Case Reports in Gastrointestinal Medicine
https://read.qxmd.com/read/38524518/efficacy-of-borneol-gypsum-in-skin-regeneration-and-pain-control-in-toxic-epidermal-necrolysis-a-case-report
#40
Lu-Wei Yang, Li-Juan Zhang, Bin-Bin Zhou, Xin-Yu Lin, Yu-Ting Chen, Xiao-Yu Qin, Hui-Ying Tian, Li-Li Ma, Ying Sun, Lin-Di Jiang
BACKGROUND: Toxic epidermal necrolysis (TEN) is a life-threatening dermatological emergency mainly induced by drug hypersensitivity reactions. Standard management includes discontinuation of culprit drug and application of immunomodulatory therapy. However, mortality remains high due to complications like septic shock and multiorgan failures. Innovative approaches for skin care are crucial. This report introduces borneol-gypsum, a traditional Chinese drug but a novel dressing serving as an adjuvant of TEN therapy, might significantly improve skin conditions and patient outcomes in TEN...
March 6, 2024: World Journal of Clinical Cases
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