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https://www.readbyqxmd.com/read/29909931/interventional-radiology-management-of-nonresectable-neoplasia
#1
REVIEW
William T N Culp
Whenever possible, surgical removal of tumors should be pursued because this likely allows for the best possible outcome for a particular patient; however, this may not be pursued for various reasons. In those situations, interventional radiology (IR) options can be considered as definitive therapy or palliation. Locoregional therapies such as intra-arterial chemotherapy and embolization/chemoembolization, while rarely reported in veterinary medicine, offer an alternative minimally invasive treatment option...
June 14, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29907175/-hypnoanalgesia-a-complementary-therapy-for-painful-care-procedures
#2
Jean-Guy Martinez, Marie-Pierre Delaunay, Nathalie Tomasso, Alexandre Guy, Thierry Joffre
In the framework of the management of patients receiving hyperbaric oxygen therapy, hypnoanalgesia is a complementary pain management tool, notably during the changing of dressings. Trained in this management of care-related pain, the teams of the hypebaric medicine centre in Lyon share their experience.
June 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29905060/therapeutic-options-to-manage-bleeding-in-a-dentist%C3%A2-s-office
#3
Claudio Rostetter, Tim Finkenstädt, Martin Rücker, Heinz-Theo Lübbers
This manuscript provides an overview of therapeutic options for the problem of bleeding in a dentist’s office. Bleeding after tooth extraction is a very common finding in dental medicine and persistent blood in the mouth is obviously uncomfortable and sometimes terrifying for the patient. Most bleedings can be stopped simply with compression, in some cases a homeostatic therapy is necessary. For local compression, a swab with tranexamic acid is useful. If local compression is not sufficient, sutures are often an option...
June 18, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29903477/model-selection-for-clustering-of-pharmacokinetic-responses
#4
Rui P Guerra, Alexandra M Carvalho, Paulo Mateus
BACKGROUND AND OBJECTIVE: Pharmacokinetics comprises the study of drug absorption, distribution, metabolism and excretion over time. Clinical pharmacokinetics, focusing on therapeutic management, offers important insights towards personalised medicine through the study of efficacy and toxicity of drug therapies. This study is hampered by subject's high variability in drug blood concentration, when starting a therapy with the same drug dosage. Clustering of pharmacokinetics responses has been addressed recently as a way to stratify subjects and provide different drug doses for each stratum...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29902906/-meta-analysis-of-traditional-chinese-medicine-jianpi-therapy-in-treatment-of-atopic-dermatitis
#5
Yong Liu, Yi-Ding Zhao, Xiao-Ning Yan
To evaluate the clinical efficacy of traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), PubMed, the Cochrane Library and EMbase database from inception to December 2017 were searched for the randomized controlled trials (RCTs) on traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager 5...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902481/precision-medicine-and-drug-development-in-alzheimer-s-disease-the-importance-of-sexual-dimorphism-and-patient-stratification
#6
REVIEW
Harald Hampel, Andrea Vergallo, Filippo Sean Giorgi, Seung Hyun Kim, Herman Depypere, Manuela Graziani, Amira Saidi, Robert Nisticò, Simone Lista
Neurodegenerative diseases (ND) are among the leading causes of disability and mortality. Considerable sex differences exist in the occurrence of the various manifestations leading to cognitive decline. Alzheimer's disease (AD) exhibits substantial sexual dimorphisms and disproportionately affects women.Women have a higher life expectancy compared to men and, consequently, have more lifespan to develop AD. The emerging precision medicine and pharmacology concepts - taking into account the individual genetic and biological variability relevant for disease risk, prevention, detection, diagnosis, and treatment - are expected to substantially enhance our knowledge and management of AD...
June 11, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29902041/it-hurts-to-move-on-a-family-s-experience-with-chronic-pain-grief-and-healing
#7
Grace S Kao
This article describes a family that had to deal with grief from losing a family member. They sought help for 13-yr-old Katie's prolonged pain following a sprain. The family's unresolved grief over their second child's passing continued to emerge, peeping through the small talk, the wry smiles, the daily efforts to move and do, despite physical pain. As the demands of Katie's rehabilitation stripped away reserves of politeness and energy, the family's emotional pain became more fully uncovered.The author describes the 6-week course of physical and occupational therapies, pain medicine management, and individual and family behavioral health support...
June 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29899281/integrative-approaches-in-pediatric-palliative-care
#8
Kate Shafto, Suzanne Gouda, Kris Catrine, Melanie L Brown
Pediatric palliative care is a field which focuses on caring for and treating the symptoms and distress typically associated with life-limiting illness. Integrative medicine is supported by evidence and aims to heal the whole person, including all aspects of one’s lifestyle. Therapies offered by integrative medicine often empower patients and families, allowing for a sense of control. This review addresses the merging of integrative medicine philosophy and modalities with the care given to children with life-limiting illness...
June 13, 2018: Children
https://www.readbyqxmd.com/read/29896468/protocol-for-an-hiv-pre-exposure-prophylaxis-prep-population-level-intervention-study-in-victoria-australia-the-prepx-study
#9
Kathleen E Ryan, Anne Mak, Mark Stoove, Brian Price, Christopher K Fairley, Simon Ruth, Luxshimi Lal, Jason Asselin, Carol El-Hayek, Long Nguyen, Colin Batrouney, David Wilson, John Lockwood, Dean Murphy, Vincent J Cornelisse, Norman Roth, Jeff Willcox, Christina C Chang, Judy Armishaw, Ban K Tee, Matthew Penn, George Forgan-Smith, Christopher Williams, Jeff Montgomery, Kat Byron, Alison Coelho, Brent Allen, Jeremy Wiggins, Jenny Kelsall, Olga Vujovic, Michael West, Anna B Pierce, Daniel Gallant, Charlotte Bell, John B F de Wit, Jennifer F Hoy, Steve L Wesselingh, Robert M Grant, Edwina J Wright
Background: Pre-exposure prophylaxis (PrEP) is the use of HIV anti-retroviral therapy to prevent HIV transmission in people at high risk of HIV acquisition. PrEP is highly efficacious when taken either daily, or in an on-demand schedule. In Australia co-formulated tenofovir-emtricitabine is registered for daily use for PrEP, however, this co-formulation is not listed yet on the national subsidized medicines list. We describe a study protocol that aims to demonstrate if the provision of PrEP to up to 3800 individuals at risk of HIV in Victoria, Australia reduces HIV incidence locally by 25% generally and 30% among GBM...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29896314/mental-stress-as-consequence-and-cause-of-vision-loss-the-dawn-of-psychosomatic-ophthalmology-for-preventive-and-personalized-medicine
#10
REVIEW
Bernhard A Sabel, Jiaqi Wang, Lizbeth Cárdenas-Morales, Muneeb Faiq, Christine Heim
The loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly a consequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nervous system (sympathetic) imbalance and vascular dysregulation; hence stress may also be one of the major causes of visual system diseases such as glaucoma and optic neuropathy...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29895725/pediatric-headache-clinic-model-implementation-of-integrative-therapies-in-practice
#11
REVIEW
Anna Esparham, Anne Herbert, Emily Pierzchalski, Catherine Tran, Jennifer Dilts, Madeline Boorigie, Tammie Wingert, Mark Connelly, Jennifer Bickel
The demand for integrative medicine has risen in recent years as research has demonstrated the efficacy of such treatments. The public has also become more conscientious of the potential limitations of conventional treatment alone. Because primary headache syndromes are often the culmination of genetics, lifestyle, stress, trauma, and environmental factors, they are best treated with therapies that are equally multifaceted. The Children’s Mercy Hospital, Kansas City, Missouri Headache Clinic has successfully incorporated integrative therapies including nutraceuticals, acupuncture, aromatherapy, biofeedback, relaxation training, hypnosis, psychology services, and lifestyle recommendations for headache management...
June 12, 2018: Children
https://www.readbyqxmd.com/read/29893975/clinical-genomics-in-physical-therapy-where-to-from-here
#12
Jon Cornwall, James M Elliott, David M Walton, Peter G Osmotherly
Clinical genomics, involving the examination of an individual's genetic material, is becoming more frequently used in healthcare. Increasingly, genomic testing is providing information that is relevant to clinical management and decision-making. Some healthcare professions, such as medicine and nursing, are integrating clinical genomics competencies into their educational frameworks to enable practitioners to work safely with patients and families who have had or require genomic testing. The uptake of clinical genomics within healthcare is of interest to physical therapist practice worldwide because of a growing direct-to-consumer accessibility to testing and the potential for such information to influence patient care as some genetic variants have been linked to many common conditions...
June 8, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29893609/racial-disparities-in-the-treatment-of-acute-overdose-in-the-emergency-department
#13
Marcee E Wilder, Lynne D Richardson, Robert S Hoffman, Gary Winkel, Alex F Manini
OBJECTIVES: Racial and ethnic disparities in the United States continue to exist in many disciplines of medicine, extending to care in the Emergency Department (ED). We sought to examine the relationship between patient race/ethnicity and use of either antidotal therapy or gastrointestinal decontamination for individuals presenting to the ED for acute drug overdose. METHODS: We completed a secondary analysis of a prospective cohort of patients with suspected acute overdose presenting to two urban tertiary care hospitals between 2009 and 2014...
June 12, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29890556/-management-of-clostridium-difficile-infections-at-german-intensive-care-units-results-from-a-survey-among-intensivists
#14
Jan Bruensing, Lukas Buendgens, Christoph Jochum, Ulf Herbers, Ali Canbay, Georg Braun, Christian Trautwein, Wolfgang Huber, Alexander Koch, Frank Tacke
BACKGROUND:  Clostridium difficile associated colitis is a frequent cause of nosocomial diarrhea at the intensive care unit (ICU) and is associated with poor prognosis in critically ill patients. Few studies have evaluated the efficacy of treatment options or adherence to guideline recommendations of Clostridium difficile infections at the ICU. METHODS:  Therefore, on behalf of the Gastroenterology Intensive Care Medicine working group of the DGVS, we have conducted an online-based survey among leading intensivists in Germany...
June 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29889537/the-development-of-18f-alf-nota-nt-as-pet-agents-of-neurotensin-receptor-1-positive-pancreatic-cancer
#15
Mengzhe Wang, He Zhang, Hui Wang, Huijuan Feng, Huaifu Deng, Zhanhong Wu, Hongjian Lu, Zi-Bo Li
Several studies have suggested that neurotensin receptors (NTRs) and neurotensin (NT) greatly affect the growth and survival of pancreatic ductal adenocarcinoma (PDAC). Developing NTR targeted PET probes could therefore be important for the management of pancreatic cancer patient by providing key information on NTR expression profile non-invasively. Despite the initial success on the synthesis of 18F labeled NT PET probes, the labeling procedure generally requires lengthy steps include azeotropic drying of 18F...
June 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29889304/dual-antibiotics-for-bronchiectasis
#16
REVIEW
Lambert M Felix, Seamus Grundy, Stephen J Milan, Ross Armstrong, Haley Harrison, Dave Lynes, Sally Spencer
BACKGROUND: Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation of the smaller airways and associated with a mortality rate greater than twice that of the general population. Antibiotics serve as front-line therapy for managing bacterial load, but their use is weighed against the development of antibiotic resistance. Dual antibiotic therapy has the potential to suppress infection from multiple strains of bacteria, leading to more successful treatment of exacerbations, reduced symptoms, and improved quality of life...
June 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29884918/the-use-of-precision-medicine-to-manage-obstructive-sleep-apnea-treatment-in-patients-with-resistant-hypertension-current-evidence-and-future-directions
#17
REVIEW
Esther Sapiña, Gerard Torres, Ferran Barbé, Manuel Sánchez-de-la-Torre
PURPOSE OF REVIEW: The significant prevalence of resistant hypertension (RH) and the high cardiovascular risk of the population of patients with RH have indicated the necessity to identify its main causes. Among these, obstructive sleep apnea (OSA) is considered the most well-established cause. RECENT FINDINGS: In recent years, several studies have shown a beneficial effect of continuous positive airway pressure (CPAP) treatment on blood pressure (BP), but this effect exhibits great variability...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29884533/copd-patient-education-and-support-achieving-patient-centredness
#18
Ana Stoilkova-Hartmann, Frits M E Franssen, Ingrid M L Augustin, Emiel F M Wouters, Katharine D Barnard
BACKGROUND: The art of medicine is undergoing a dramatic shift in focus, evolving to focus on patient involvement as partners in care, transforming the traditional, prescriptive, reactive practice of healthcare into a proactive discipline. The personal and societal burden of chronic diseases is burgeoning and unsustainable in current systems, novel approaches are required to address this. DISCUSSION: Although considerable progress has been made in the development of diagnostics, therapeutics and care guidelines for patients with chronic obstructive pulmonary disease (COPD), questions remain surrounding the implementation of best practice education and support...
June 1, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29880438/identification-management-and-transition-of-care-for-patients-with-opioid-use-disorder-in-the-emergency-department
#19
REVIEW
Herbert C Duber, Isabel A Barata, Eric Cioè-Peña, Stephen Y Liang, Eric Ketcham, Wendy Macias-Konstantopoulos, Shawn A Ryan, Mark Stavros, Lauren K Whiteside
Because of a soaring number of opioid-related deaths during the past decade, opioid use disorder has become a prominent issue in both the scientific literature and lay press. Although most of the focus within the emergency medicine community has been on opioid prescribing-specifically, on reducing the incidence of opioid prescribing and examining alternative pain treatment-interest is heightening in identifying and managing patients with opioid use disorder in an effective and evidence-based manner. In this clinical review article, we examine current strategies for identifying patients with opioid use disorder, the treatment of patients with acute opioid withdrawal syndrome, approaches to medication-assisted therapy, and the transition of patients with opioid use disorder from the emergency department to outpatient services...
June 4, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29880089/assessment-of-oral-anticoagulation-control-at-pharmacist-managed-clinics-a-retrospective-cohort-study
#20
E Kose, T An, A Kikkawa
In chronic kidney disease (CKD) patients, the ratio of warfarin enantiomers is changed and becomes unstable due to a reduction of cytochrome P450 (CYP) 2C9 activity of, which contributes to the development of hemorrhagic complications. The aim of this study was to investigate the influence of interventions by clinical pharmacists in addition to guidance by physicians on time in therapeutic range (TTR) control of warfarin therapy for CKD patients with non-valvular atrial fibrillation (NVAF). This retrospective cohort study included NVAF patients with CKD admitted and discharged from a cardiovascular internal medicine ward between March 2011 and July 2013 in Yokosuka Kyousai Hospital...
June 1, 2018: Die Pharmazie
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