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Keloid

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https://www.readbyqxmd.com/read/28219131/-recombinant-human-bone-morphogenetic-protein-7-inhibits-the-proliferation-and-extracellular-matrix-secretion-of-fibroblast-of-urethral-scars
#1
Y Wu, L M Ma, B Cai, H L Li, Q W Xing
Objective: To study the effect and its mechanism of recombinant human bone morphogenetic protein 7 (rhBMP-7) on urethral keloid fibroblast. Methods: Urethral fibroblasts were extracted and cultured, and the fourth-generation fibroblasts were used for experiment. Urethral fibroblasts were treated with rhBMP-7. Proliferation rate was detected by CCK-8 method. RT-PCR was applied to test changes of mRNA in α smooth muscle actin (α-SMA) and type Ⅰ collagen protein (COL-1) of each group. Western blot was used to measure α-SMA protein expression and the effect of rhBMP-7 on signaling pathway of urethral keloid fibroblasts...
February 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28216825/surgical-excision-and-contoured-custom-made-splint-to-treat-helical-keloid
#2
Ankita Chamaria, Reuben Fernando De Sousa, Meena Ajay Aras, Kennedy Mascarenhas
Helical keloids are difficult to treat as surgical excision requires effective compression of the operative scar to prevent recurrence while retaining the contour and elasticity of the helix. The authors fabricated a conforming custom made post-operative splint from a commonly used dental material. Splints could be fabricated in both pre-operative and post-operative stage.
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28195846/color-doppler-ultrasound-assessment-of-activity-in-keloids
#3
Nelson Lobos, Ximena Wortsman, Fernando Valenzuela, Faustino Alonso
BACKGROUND: The assessment of activity in keloids may be critical for defining their management. There is a lack of clinical scorings designed for the evaluation of keloids and biopsies may be contraindicated. OBJECTIVE: To assess the sonographic activity of keloids in comparison with clinical scoring. MATERIALS AND METHODS: A retrospective study of the clinical and color Doppler ultrasound (CDU) images of patients medically derived to CDU with the diagnosis of keloid was performed...
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28192879/knockdown-of-irf3-inhibits-extracellular-matrix-expression-in-keloid-fibroblasts
#4
Yi Zhang, Li Zhang, Xiao-Hua Lin, Zhi-Ming Li, Qi-Yu Zhang
Keloid is a pathologic fibro-proliferative disorder and is characterized by hyper-proliferation of fibroblasts and excess extracellular matrix (ECM) deposition. Interferon regulatory factor 3 (IRF3) is a member of the interferon-regulatory factor (IRF) family and has been shown to play a critical modulator in the progression of fibrosis. However, the function of IRF3 in dermal fibrosis remains unclear. Thus, in this study, we investigated the effects of IRF3 on keloid-derived fibroblasts (KFs) proliferation and ECM expression, and explored the underlying mechanism...
February 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28190657/cross-sectional-analysis-of-biobank-japan-clinical-data-a-large-cohort-of-200-000-patients-with-47-common-diseases
#5
Makoto Hirata, Yoichiro Kamatani, Akiko Nagai, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda
BACKGROUND: To implement personalized medicine, we established a large-scale patient cohort, BioBank Japan, in 2003. BioBank Japan contains DNA, serum, and clinical information derived from approximately 200,000 patients with 47 diseases. Serum and clinical information were collected annually until 2012. METHODS: We analyzed clinical information of participants at enrollment, including age, sex, body mass index, hypertension, and smoking and drinking status, across 47 diseases, and compared the results with the Japanese database on Patient Survey and National Health and Nutrition Survey...
February 9, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28177974/optimizing-radiotherapy-for-keloids-a-meta-analysis-systematic-review-comparing-recurrence-rates-between-different-radiation-modalities
#6
Peter Mankowski, Jonathan Kanevsky, Jared Tomlinson, Alina Dyachenko, Mario Luc
BACKGROUND: The high recurrence rate of keloids has lead to the use of multiple treatment adjuncts to improve cosmetic outcomes after surgery. To date, there has been no single, standardized modality agreed upon to produce the best results. The purpose of this study was to review the radiation-based treatments (brachytherapy, electron beam and X-ray) used for keloid management and compare their outcomes. METHODS: A literature review was performed from 1942 to October 2014 using the databases: PubMed database of the National Center of Biotechnology Information, MEDLINE, Biosis, Embase, Google scholar, and Cochrane database...
February 8, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28163460/diode-laser-ear-piercing-a-novel-technique
#7
Bibilash Babu Suseela, Preethitha Babu, Ravi Kumar Chittoria, Devi Prasad Mohapatra
Earlobe piercing is a common office room procedure done by a plastic surgeon. Various methods of ear piercing have been described. In this article, we describe a novel method of laser ear piercing using the diode laser. An 18-year-old female patient underwent an ear piercing using a diode laser with a power of 2.0 W in continuous mode after topical local anaesthetic and pre-cooling. The diode laser was fast, safe, easy to use and highly effective way of ear piercing. The advantages we noticed while using the diode laser over conventional methods were more precision, minimal trauma with less chances of hypertrophy and keloids, no bleeding with coagulation effect of laser, less time taken compared to conventional method and less chance of infection due to thermal heat effect of laser...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28149806/robotic-retroauricular-thyroid-surgery
#8
REVIEW
Haytham Alabbas, Daniah Bu Ali, Emad Kandil
Surgery is the gold standard treatment for patients with thyroid cancer or nodules suspicious for cancer. Open conventional approach is the standard surgical approach. However, a visible neck incision could be a concern for most young female patients, especially for patients with a history of healing with keloid or hypertrophic scars. Robotic remote access approaches have evolved into a safe and feasible approach in selected patients, providing a hidden scar with good patient satisfaction. This review will focus on the performance and safety of robotic retroauricular thyroid surgery...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28139418/postoperative-single-dose-interstitial-high-dose-rate-brachytherapy-in-therapy-resistant-keloids
#9
C J H Hafkamp, O Lapid, R Dávila Fajardo, A L van de Kar, C Koedooder, L J Stalpers, B R Pieters
PURPOSE: Patients with keloids complain of the cosmetic aspect, pain, and pruritus. Many different therapies are being used for keloids. The aim of this study was to evaluate the recurrence rate and outcome after resection followed by a single-dose brachytherapy. METHODS AND MATERIALS: Patients treated by resection of the keloid plus a single dose of 13 Gy high-dose-rate brachytherapy were evaluated at least 1 year after treatment. Clinical response and cosmesis were assessed by a plastic surgeon and by the patients using the Patient and Observer Scar Assessment Scale...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28138959/growing-trend-of-tattooing-and-its-complications-in-nigeria
#10
REVIEW
Olusola O Ayanlowo, Shakirat A Gold-Olufadi, Ayesha O Akinkugbe, Erere Otrofanowei, Charles N Nga, Yetunde M Olumide
Tattoo, a Polynesian word meaning 'to mark', is a form of body modification done by inserting indelible ink into the dermis to change its pigmentation. Tattoos are done for social, cultural, and religious purposes. It has been in existence since the 18th century and was associated with sailors, lower class individuals, and criminals. However, since the late 20th century, tattooing has undergone a redefinition and shifted to an acceptable form of expression all over the world, including Nigeria, cutting across almost all age groups and socioeconomic class...
January 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28130757/microrna-29-a-crucial-player-in-fibrotic-disease
#11
REVIEW
Zhenjun Deng, Yongjing He, Xujuan Yang, Hang Shi, Ao Shi, Lechun Lu, Li He
Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases...
January 28, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28129011/intratracheal-keloid
#12
Randall Craver
BACKGROUND: Keloidal scarring can complicate surgical procedures. CASE REPORT: This 21-month-old African-American child developed a keloid around his tracheostomy that extended into the trachea. CONCLUSION: Keloidal formation from a tracheostomy site can extend into the trachea.
January 27, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28124198/laser-assisted-topical-corticosteroid-delivery-for-the-treatment-of-keloids
#13
Ji Hye Park, Ji Young Chun, Jong Hee Lee
Laser-assisted drug delivery has generated intense interest. The objectives of this study are to evaluate the clinical benefit of laser-assisted corticosteroid delivery and to compare this technique to corticosteroid intralesional injection, a standard treatment for keloids. Patients with keloids on the left shoulder after BCG vaccination were enrolled in this study. The entire lesion was first treated with an ablative fractional erbium-YAG laser. After this treatment, the lesion was divided into two halves...
January 26, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28121872/discussion-identification-of-key-modules-and-hub-genes-of-keloids-with-weighted-gene-coexpression-network-analysis
#14
Rei Ogawa
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28121871/identification-of-key-modules-and-hub-genes-of-keloids-with-weighted-gene-coexpression-network-analysis
#15
Wenhui Liu, Xiaolu Huang, Xiao Liang, Yiwen Zhou, Haizhou Li, Qingxiong Yu, Qingfeng Li
BACKGROUND: Keloid scarring impairs patients' quality of life, and although many therapeutic strategies have been developed, most remain unsatisfactory because of limited understanding of the mechanisms underlying keloid development. METHODS: A microarray gene expression data set from keloid tissue was acquired from the Gene Expression Omnibus. Differentially expressed genes in fibroblasts and keratinocytes underwent functional annotation and pathway analysis. Weighted gene coexpression network analysis was applied to identify the gene targets of keloid scars within differentially expressed genes...
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28120534/sulforaphane-suppresses-cell-growth-and-collagen-expression-of-keloid-fibroblasts
#16
Ayako Kawarazaki, Mano Horinaka, Shusuke Yasuda, Toshiaki Numajiri, Kenichi Nishino, Toshiyuki Sakai
Keloids are fibroproliferative diseases characterized by the accumulation of an extracellular matrix including collagen. Various growth factors, or cytokines, and their receptors are overexpressed in keloids, and they are expected to be therapy targets. Sulforaphane, a dietary isothiocyanate, has recently shown anti-tumor, anti-inflammatory, and anti-fibrotic properties. In this study, we found that sulforaphane inhibited cell growth and reduced collagen at the mRNA and protein levels in keloid fibroblasts...
January 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28109484/pediatric-trans-oral-submandibular-gland-excision-a-safe-and-effective-technique
#17
C A Hughes, J Brown
INTRODUCTION: In the pediatric population the submandibular gland requires removal in a number of conditions including, refractory recurrent sialoadenitis, sialolithiasis, salivary gland neoplasms and debilitating sialorrhea. In comparison to the traditional trans-cervical approach, the trans-oral route avoids a cervical scar, potential keloid formation and decreased risk of injury to the marginal mandibular branch of the facial nerve. This approach also eliminates the potentiality of remnant duct disease since the entire duct and papillae are removed...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28108300/transforming-growth-factor-beta-inducible-early-gene-1-tieg1-represses-smad7-mediated-activation-of-tgf-%C3%AE-1-smad-signaling-in-keloid-pathogenesis
#18
Zhi-Cheng Hu, Fen Shi, Peng Liu, Jian Zhang, Dong Guo, Xiao-Ling Cao, Chu-Fen Chen, Shanqiang Qu, Jia-Yuan Zhu, Bing Tang
Transforming growth factor β (TGF-β)/Smad signaling plays a key role in excessive fibrosis and keloid formations. Smad7 is a negative feedback regulator that prevents activation of TGF-β/Smad signaling. However, the regulatory mechanism for Smad7 in the keloid pathogenic process remains elusive. Here, we show that expression of TGF-β inducible early gene-1 (TIEG1) is markedly higher in keloid fibroblasts (KFs), while protein, mRNA, and promoter activity levels of Smad7 are decreased. When TIEG1 was knocked down with small interfering RNA (siRNA), both the promoter activity and protein expression of Smad7 were increased, while collagen production and the proliferation, migration, and invasion of KFs were decreased...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28101157/functional-analysis-of-keratinocyte-and-fibroblast-gene-expression-in-skin-and-keloid-scar-tissue-based-on-deviation-analysis-of-dynamic-capabilities
#19
Mingming Li, Lei Wu
The aim of the present study was to select key genes that are associated with fibroblasts and keratinocytes during keloid scar progression and development. The gene expression profile of GSE44270, which includes 32 samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in case samples compared with control samples were screened using the Limma R package followed by hierarchical clustering analysis. Protein-protein interaction (PPI) networks of the total selected DEGs were constructed using Cytoscape...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28095559/comparative-results-in-treatment-of-keloids-with-intralesional-5-fu-kenalog-5-fu-verapamil-enalapril-alone-verapamil-alone-and-laser-a-case-report-and-review-of-the-literature
#20
Doru Alexandrescu, Sabrina Fabi, Lindsey C Yeh, Richard E Fitzpatrick, Mitchel P Goldman
BACKGROUND: The pathogenesis of keloids involves a hyperproliferative state due to molecular abnormalities, cellular driving pathways, such as TGF, VEGF, and the inactivation of proapoptotic genes. We reviewed the literature and compared various treatment combina- tions in the treatment of keloids in a one patient observation. METHODS AND MATERIALS: Treatment modalities consisted of: intralesional 5- uorouracil (5-FU)/triamcinolone (TMC), 5-FU/verapamil, enal- april alone, verapamil alone, and fractional carbon dioxide laser...
November 1, 2016: Journal of Drugs in Dermatology: JDD
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