keyword
MENU ▼
Read by QxMD icon Read
search

Keloid

keyword
https://www.readbyqxmd.com/read/29224036/laser-advances-in-the-treatment-of-burn-and-traumatic-scars
#1
Shilpi Khetarpal, Urvashi Kaw, Jeffrey S Dover, Kenneth A Arndt
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can be used to revitalize and restore damaged skin in atrophic and hypertrophic scars. The most commonly used lasers are the pulsed-dye laser (PDL) and fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29218275/outcomes-of-surgical-excision-and-brachytherapy-in-intractable-keloids
#2
Ahmadreza Taheri, Hojjat Molaei, Mehdi Aghili, Naser Rahmanpanah, Atefeh Mirmohseni
BACKGROUND: Keloids as unusual scars are injury remnants characterized by bizarre cosmetics and painful itching. This study assessed outcomes of surgical excision and brachytherapy in intractable keloids. METHODS: Six patients with 10 keloid lesions were followed up. Surgical excision was done with 1-2 mm margin, and then radiotherapy was undertaken in 3 divided fractions on days 0, 1 and 2 after surgery. Scar improvement was evaluated by patients and observer with scar assessment scale (POSAS)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29204684/dna-methylation-of-the-cdc2l1-gene-promoter-region-decreases-the-expression-of-the-cdk11p58-protein-and-reduces-apoptosis-in-keloid-fibroblasts
#3
Gang Zhang, QiaoYu Guan, Guizong Chen, Fang Qian, Jie Liang
The excessive growth of fibroblasts in keloid is closely related to the status of gene methylation. The aim of this project was to study whether keloid development is related to DNA methylation in the CDC2L1 gene promoter region. DNA methylation of the promoter of this gene was analyzed by bisulfite sequencing and verified by DNA methylation-specific polymerase chain reaction. The results showed that the DNA methylation rate of CpG islands in the CDC2L1 gene promoter region was 50.0% (12/24) in patient keloid tissues and 0% (0/24) in normal skin-tissues from healthy controls...
December 4, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29199803/keloid-like-reaction-to-cocaine-use
#4
Raffaele D Caposiena Caro, Mauro Mazzeo, Dario Didona, Ester Del Duca, Ilaria DE Simoni, Luca Bianchi
No abstract text is available yet for this article.
December 1, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29194570/characterization-of-cd45ro-memory-t-lymphocytes-in-keloid-disease
#5
Z Chen, L Zhou, T Won, Z Gao, X Wu, L Lu
BACKGROUND: Memory T cells, a highly effective subset of T lymphocytes, have been reported to be involved in many inflammatory skin disorders. However, the potential role of memory T cells in keloid disease (KD) remains unclear. OBJECTIVES: Due to their important role in regulating inflammation, we investigated the characteristics of CD45RO+ memory T cells (mT) in KD. METHODS: Primary cutaneous cells were isolated from keloid scars and normal skin by enzymic digestion...
December 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29190966/microrna-21-inhibits-mitochondria-mediated-apoptosis-in-keloid
#6
Hao Wu, Jie Wang, Hui Ma, Zhibo Xiao, Xiaoqun Dong
MicroRNA-21 acts as an oncogene by promoting cell proliferation and migration, whereas inhibiting apoptosis in majority of cancers. MicroRNA-21 is upregulated in human keloid fibroblasts. We hypothesized that microRNA-21 may contribute to pathogenesis of keloid fibroblasts. First, enhanced miR-21 but reduced mitochondrial-mediated apoptosis observed in keloid tissues indicated its importance in keloids development. Second, upregulation of microRNA-21 induced a decrease in the ratio of BAX to BCL-2 and suppressed mitochondrial fission in keloid fibroblasts...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29186868/could-79-%C3%A2-c-spray-type-cryotherapy-be-an-effective-monotherapy-for-the-treatment-of-keloid
#7
Tae Hwan Park, Hyeon-Ju Cho, Jang Won Lee, Chan Woo Kim, Yosep Chong, Choong Hyun Chang, Kyung-Soon Park
Cryotherapy has been regarded as an effective modality for the treatment of keloids, and the spray-type device is one of the novel cryotherapeutic units. However, the biological mechanisms and therapeutic effects of this technique are incompletely studied. We evaluated the clinical efficacy of our cryotherapy protocol with molecular and pathologic evidence for the treatment of keloids. We evenly split each of ten keloid lesions into a non-treated (C-) and treated (C+) area; the C+ area was subjected to two freeze-thaw cycles of spray-type cryotherapy using -79 °C spray-type CryoPen™...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29169897/wound-healing
#8
REVIEW
Peng-Hui Wang, Ben-Shian Huang, Huann-Cheng Horng, Chang-Ching Yeh, Yi-Jen Chen
Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or chronic wound (ulcer) impairs the normal physical function. A large number of sophisticated experimental studies have provided insights into wound healing...
November 21, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29163221/the-superficial-dermis-may-initiate-keloid-formation-histological-analysis-of-the-keloid-dermis-at-different-depths
#9
Hu Jiao, Tiran Zhang, Jincai Fan, Ran Xiao
Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29152302/surgical-management-of-extensive-hypertrophic-scarring-of-the-halluces-secondary-to-a-decade-of-untreated-onychocryptosis-an-illustrative-case-report
#10
Dean J Samaras, Andrew C Kingsford
Extensive hypertrophic scarring of the halluces secondary to chronic onychocryptosis is a rare condition, which causes significant physical and psychosocial effects. In this case, a 31-year-old male developed large lesions on both great toes after he delayed treatment of chronic hallucal onychocryptosis for over a decade. Current treatment options for hypertrophic and keloid lesions in the foot and ankle vary considerably and differentiation is critical for appropriate treatment planning. In this case, surgical excision with total matrixectomy (modified Zadik-Syme) was considered optimal management...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29145520/opposite-effects-of-non-thermal-plasma-on-cell-migration-and-collagen-production-in-keloid-and-normal-fibroblasts
#11
Sung Un Kang, Yeon Soo Kim, Yang Eun Kim, Ju-Kyeong Park, Yun Sang Lee, Hee Young Kang, Jae Won Jang, Jeong Beom Ryeo, Yuijina Lee, Yoo Seob Shin, Chul-Ho Kim
Recent progress in the understanding non-thermal plasma (NTP) properties prompted its application in the treatment of various diseases. However, therapeutic effect of NTP on keloid cells has not been reported previously. We sought to investigate the effect of NTP treatment on keloid by comparing cell migration and collagen production of keloid (KFs) and normal fibroblasts (NFs) and determined the regulatory pathways involved. We assessed NTP effects on cell migration in KFs and NFs by the wound healing assay and measured the expression of the epidermal growth factor receptor (EGFR), signal transducer and activator of transcription-3 (STAT3), and collagen by western blot...
2017: PloS One
https://www.readbyqxmd.com/read/29142785/role-of-cord-blood-and-bone-marrow-mesenchymal-stem-cells-in-recent-deep-burn-a-case-control-prospective-study
#12
Wael Abo-Elkheir, Fawzy Hamza, Ahmed M Elmofty, Atef Emam, Magdy Abdl-Moktader, Sameh Elsherefy, Hala Gabr
RATIONALE: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Thus, they are thought to play a key role in wound healing inducing efficient and physiological skin regeneration...
2017: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29139364/advanced-management-of-severe-keloids
#13
REVIEW
Thomas Hagele, Hoka Nyanda, Nishit Patel, Nicole Russell, George Cohen, Christopher Nelson
Keloids negatively impact the health and quality of life of many affected dermatologic patients. Treating keloids is often difficult, and suboptimal responses are frequent. Fortunately, there are many treatment options available to the clinician that may lead to improved clinical outcomes. We present a review of currently available therapeutic options. Intralesional steroid injection remains the first-line treatment for keloids. Imiquimod, direct interferon therapy, or intralesional 5-flurouracil may alleviate the need for excessive corticosteroid therapy...
2017: Skinmed
https://www.readbyqxmd.com/read/29132871/the-role-of-tgf%C3%AE-in-wound-healing-pathologies
#14
REVIEW
Dimitra Kiritsi, Alexander Nyström
Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Chronic wounds are defined as barrier defects that have not proceeded through orderly and timely reparation to regain structural and functional integrity...
November 10, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29122407/three-dimensional-poly-lactic-co-glycolic-acid-scaffold-containing-autologous-platelet-rich-plasma-supports-keloid-fibroblast-growth-and-contributes-to-keloid-formation-in-a-nude-mouse-model
#15
Chunlin Chen, Haibin Wang, Guozhang Zhu, Zhongsheng Sun, Xiang Xu, Fangwei Li, Shengkang Luo
BACKGROUND: There is a lack of proper animal models to study keloid formation. AIM: To create three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds containing autologous platelet-rich plasma (PRP) as an in vitro culture environment for keloid fibroblasts (KL), and to study their implantation into nude mice to mimic the process of keloid formation. METHODS: Normal fibroblasts (FB) and KL cells were isolated from surgical specimens and transduced with lentivirus loaded with green fluorescent protein (GFP) and luciferase genes...
October 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29118355/decoy-wnt-receptor-slrp6e1e2-expressing-adenovirus-induces-anti-fibrotic-effect-via-inhibition-of-wnt-and-tgf-%C3%AE-signaling
#16
Won Jai Lee, Jung-Sun Lee, Hyo Min Ahn, Youjin Na, Chae Eun Yang, Ju Hee Lee, JinWoo Hong, Chae-Ok Yun
Aberrant activation of the canonical Wingless type (Wnt) signaling pathway plays a key role in the development of hypertrophic scars and keloids, and this aberrant activation of Wnt pathway can be a potential target for the development of novel anti-fibrotic agents. In this study, we evaluated the anti-fibrotic potential of a soluble Wnt decoy receptor (sLRP6E1E2)-expressing non-replicating adenovirus (Ad; dE1-k35/sLRP6E1E2) on human dermal fibroblasts (HDFs), keloid fibroblasts (KFs), and keloid tissue explants...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116332/-therapy-of-scars-with-lasers
#17
REVIEW
G G Gauglitz, J Pötschke, M T Clementoni
Scar formation is the consequence of trauma to the skin that affects the deep parts of the dermis. Different scar types like immature, mature, atrophic, hypertrophic, or keloid scars can develop depending on factors like age, anatomic localization, cause of trauma, the course of the healing process, and individual predispositions. Keloids and hypertrophic scars are often associated with itching, pain, tautness of the skin, and functional impairments, thus, leading to significantly reduced quality of life in some patients...
November 7, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29105155/the-tension-biology-of-wound-healing
#18
REVIEW
Hans I-Chen Harn, Rei Ogawa, Chao-Kai Hsu, Michael W Hughes, Ming-Jer Tang, Cheng-Ming Chuong
Following skin wounding, the healing outcome can be; regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue, or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing, and adult scar keloid formation...
November 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29102488/a-simple-device-for-ablation-of-keloidal-tissue-and-serial-deposition-of-intralesional-drugs
#19
Savita Yadav, Somesh Gupta
No abstract text is available yet for this article.
November 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29098727/bilateral-breast-keloids-in-an-elderly-woman-associated-with-bilateral-breast-cancers-and-high-concentration-of-serum-tumor-growth-factor-%C3%AE
#20
Masanobu Sakaguchi, Takeshi Fukumoto, Fumiyoshi Fujishima, Kaori Fukuda, Takeshi Kozaru, Masao Ban, Masahiro Oka
We report a case of bilateral annular breast keloids in a 72-year-old woman who had been suffering from bilateral breast cancers. Histopathologically, the keloids showed unique distribution of α-SMA+, CD34- myofibroblasts and α-SMA-, CD34+ fibroblasts depending on the region. High serum levels of tumor growth factor-β were detected at 6 months after the development of the breast keloids, but not at 10 months. CD163-positive cells were abundantly detected in the skin of the elevated portion of the keloids...
November 2017: Journal of Dermatology
keyword
keyword
24006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"