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https://www.readbyqxmd.com/read/28092339/beta-adrenergic-receptor-blockers-reduce-the-occurrence-of-keloids-and-hypertrophic-scars-after-cardiac-device-implantation-a-single-institution-case-control-study
#1
Tatsuki Enoshiri, Motoko Naitoh, Satoko Yamawaki, Atsushi Kawaguchi, Rino Aya, Kazuo Noda, Yasuhiro Katayama, Takahiro Doi, Tetsuma Kawaji, Shigehiko Suzuki
No abstract text is available yet for this article.
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28088270/association-of-plasminogen-activator-inhibitor-1-and-vitamin-d-receptor-expression-with-the-risk-of-keloid-disease-in-a-chinese-population
#2
Zhen-Hua Gong, Jian-Feng Ji, Jun Yang, Tie Xiang, Chang-Kai Zhou, Xuan-Liang Pan, Jian Yao
Keloid disease (KD) is a benign fibroproliferative scarring condition of unknown etiopathogenesis. Plasminogen activator inhibitor-1 (PAI-1) and vitamin D receptor (VDR) have been shown to play important roles in the progression of tissue fibrosis; therefore, both these genes are potential susceptibility genes for KD. We aimed to determine whether the gene expression levels of PAI-1 and VDR are altered in Chinese KD patients. We measured the expression of PAI and VDR in human peripheral blood lymphocytes in 236 patients with keloid and 219 age- and sex-matched healthy controls by quantitative real-time polymerase chain reaction...
January 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28077400/differential-expression-of-hedgehog-and-snail-in-cutaneous-fibrosing-disorders-implications-for-targeted-inhibition
#3
Amrita Goyal, Katy R Linskey, Jonathan Kay, Lyn M Duncan, Rosalynn M Nazarian
OBJECTIVES: To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition. METHODS: Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (Ihh), Patched (Ptch), glycogen synthase kinase 3 β (GSK3-β), β-catenin, and Snail were evaluated in human skin biopsy specimens of keloid, hypertrophic scar (Hscar), scleroderma, nephrogenic systemic fibrosis (NSF), scar, and normal skin using a tissue microarray...
December 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28065541/nodular-fasciitis-sonographic-pathologic-correlation
#4
Ho-Hsian Yen, Hong-Jen Chiou, Yi-Hong Chou, Chih-Hsueh Chen, Wan-Yuo Guo
We evaluated nodular fasciitis (NF) in 19 patients, focusing on the correlation between its sonographic and histopathologic features. Sonograms were retrospectively reviewed, and the location, shape, margin, echogenicity, echogenic rim, peripheral hyper-echoic nodules, posterior enhancement and vascularity of the lesions were recorded. In the histopathologic analysis, three patterns-infiltrating, pushing border and well circumscribed-were identified, and culture-like tissue centers were classified according to the distribution of focal keloid-like collagen bundles: uneven or even...
January 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28059714/regeneration-of-fat-cells-from-myofibroblasts-during-wound-healing
#5
Maksim V Plikus, Christian F Guerrero-Juarez, Mayumi Ito, Yun Rose Li, Priya H Dedhia, Ying Zheng, Mengle Shao, Denise L Gay, Raul Ramos, Tsai-Ching His, Ji Won Oh, Xiaojie Wang, Amanda Ramirez, Sara E Konopelski, Arijh Elzein, Anne Wang, Rarinthip June Supapannachart, Hye-Lim Lee, Chae Ho Lim, Arben Nace, Amy Guo, Elsa Treffeisen, Thomas Andl, Ricardo N Ramirez, Rabi Murad, Stefan Offermanns, Daniel Metzger, Pierre Chambon, Alan D Widgerow, Tai-Lan Tuan, Ali Mortazavi, Rana K Gupta, Bruce A Hamilton, Sarah E Millar, Patrick Seale, Warren S Pear, Mitchell A Lazar, George Cotsarelis
Although regeneration via the reprogramming of one cell lineage to another occurs in fish and amphibians, it is not observed in mammals. We discovered in mouse that during wound healing adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and non-adipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered BMP signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist, noggin, in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation...
January 5, 2017: Science
https://www.readbyqxmd.com/read/28056485/evidence-of-invasive-and-non-invasive-treatment-modalities-for-hypertrophic-scars-a-systematic-review
#6
Mona Kafka, Vanessa Collins, Lars-Peter Kamolz, Thomas Rappl, Ludwik K Branski, Paul Wurzer
Currently, there are various therapeutic approaches to reduce hypertrophic scarring, however, there is no standard evidence-based treatment protocol. Hence, we performed a systematic review to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars...
January 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28054407/from-genetics-to-epigenetics-new-insights-into-keloid-scarring
#7
REVIEW
Yongjing He, Zhenjun Deng, Mansour Alghamdi, Lechun Lu, Mark W Fear, Li He
Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars...
January 5, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28044352/delayed-allergic-dermatitis-presenting-as-a-keloid-like-reaction-caused-by-sting-from-an-indo-pacific-portuguese-man-o-war-physalia-utriculus
#8
B E K Guevara, J F Dayrit, V Haddad
Cnidarian envenomations are common occurrences in the tropics that can affect holidaymakers. The cutaneous reactions are classified as immediate or delayed types. Delayed allergic reactions are persistently recurring dermatitis, which can occur within 1-4 weeks from the initial sting, and may last for several months. Hypertrophic scar-like or keloid-like reactions are rare, and are believed to be a type IV hypersensitivity reaction to sequestered antigens from stinging filaments. We report an unusual case of delayed allergic dermatitis with keloid-like presentation caused by Physalia utriculus...
January 2, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28033625/-analysis-of-critically-perfused-tissues-by-laser-speckle-contrast-analysis-lasca-perfusion-imaging
#9
A Limbourg, C Radtke, R Ipaktchi, P M Vogt
Background: The success of tissue transplantation and long-term tissue stability after wound healing depends on sufficient tissue perfusion. Laser Doppler-supported procedures allow for an objective measurement of relative tissue perfusion. The development of Speckle-based Laser Doppler imaging now enables a real-time representation of tissue perfusion. The perfusion of tissues relevant in plastic surgery such as scars, phalangeal replantations and burn wounds were systematically analysed by Laser Speckle Contrast Analysis (LASCA) imaging...
December 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28027270/a-novel-approach-to-keloid-reconstruction-with-bilaminar-dermal-substitute-and-epidermal-skin-grafting
#10
Christian Pascone, Juri Tassinari, Tommaso Agostini, Davide Lazzeri, Francesco Figliuolo, Andrea Sisti
No abstract text is available yet for this article.
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027198/a-topical-anesthetic-and-lidocaine-mixture-for-pain-relief-during-keloid-treatment-a-double-blind-randomized-controlled-trial
#11
Arnik Usanakornkul, Chairat Burusapat
BACKGROUND: Keloids are abnormal overgrowth of collagen fibers, and the first-line treatment includes intralesional injection of triamcinolone acetonide (TA), which is associated with pain. OBJECTIVE: To study the benefit of applying topical anesthetics or a 1:1 mixture of 1% lidocaine and TA at the TA injection site to alleviate pain during keloid treatment. METHODS AND MATERIALS: A double-blind, randomized controlled trial was conducted...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28009689/a-comparison-of-gene-expression-of-decorin-and-mmp13-in-hypertrophic-scars-treated-with-calcium-channel-blocker-steroid-and-interferon-a-human-scar-carrying-animal-model-study
#12
Shih-Yi Yang, Jui-Yung Yang, Yen-Chang Hsiao, Shiow-Shuh Chuang
BACKGROUND: The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response. In a previous study, an animal model with human scar tissue implanted into nude mice (BALB/c) has been successfully established. The effects of verapamil as well as combination therapy with verapamil and kenacort have been studied and compared. OBJECTIVE: To treat persistent hypertrophic scars, local injection of drugs composed of steroids, calcium channel blockers (CCBs), and interferon might be a good method...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28009688/introduction-to-special-issue-on-hypertrophic-scars-and-keloids
#13
Thomas E Rohrer, Michael Gold
No abstract text is available yet for this article.
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28008278/acne-keloidalis-nuchae-prevalence-impact-and-management-challenges
#14
REVIEW
Adebola Ogunbiyi
Acne keloidalis nuchae (AKN) also known as folliculitis keloidalis nuchae (FKN) is a chronic form of scarring folliculitis seen mostly in men of African descent. The term AKN is commonly used even though the condition is not a keloid, and the affected individuals do not have a tendency to develop keloids in other areas of the body. It is seen in post pubertal men and is rare after the age of 55 years. A few cases have been reported in females. which has been classified as a primary cicatricial alopecia since the exact cause of acne keloidalis (AK) remains unknown...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28005821/strategy-for-successful-management-of-facial-keloid-using-triamcinolone-injection-as-adjunct-to-surgery
#15
Bayo Aluko-Olokun, Ademola Abayomi Olaitan
The literature on keloids is replete with authors expressing frustration with treatment results. Triamcinolone is effective in shrinking keloids and preventing their recurrence following excision, if delivered successfully. Strategies for effective delivery of drug are presented: recommended needle size, use of metal syringe, slow injection to avoid skin rupture, and delayed withdrawal of needle after injection. The futility of expecting pedunculated keloids to be completely flattened by steroid injection alone is mentioned...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28002104/laser-treatment-of-keloid-scars
#16
Faisal R Ali, Emily Forbat, Firas Al-Niaimi
No abstract text is available yet for this article.
December 19, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28001261/evidences-of-autologous-fat-grafting-for-the-treatment-of-keloids-and-hypertrophic-scars
#17
Vinícius Zolezi DA Silva, Antonio Albacete, Grazielle DE Souza Horácio, Guilherme Augusto Magalhães DE Andrade, Leandro Debs Procópio, Pedro Soler Coltro, Jayme Adriano Farina
Introduction: Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature...
December 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27995750/keloid-progression-a-stiffness-gap-hypothesis
#18
Chenyu Huang, Longwei Liu, Zhifeng You, Bingjie Wang, Yanan Du, Rei Ogawa
Keloids are fibroproliferative skin disorders characterised clinically by continuous horizontal progression and post-surgical recurrence and histologically by the accumulation of collagen and fibroblast ingredients. Till now, their aetiology remains clear, which may cover genetic, environmental and metabolic factors. Evidence in the involvement of local mechanics (e.g. predilection site and typical shape) and the progress in mechanobiology have incubated our stiffness gap hypotheses in illustrating the chronic but constant development in keloid...
December 19, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27994646/postoperative-radiotherapy-in-the-management-of-keloids
#19
Claudia C Carvajal, Carla M Ibarra, Douglas L Arbulo, Moisés N Russo, Claudio P Solé
BACKGROUND: The high recurrence rate following keloid resection has generated interest in adjuvant treatments for this disease. OBJECTIVE: This study assesses keloid recurrence when treated with surgery and adjuvant radiotherapy. METHODS: Retrospective analysis of resected keloids in patients referred to a Chilean radiation oncology centre between 2006 and 2013. Local recurrence was defined as new tissue growth on the surgical scar margin...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27992948/pinnaplasty-improved-access-to-the-anti-helical-fold
#20
J Tahery, G H Jones, S Shah
Prominent ears affect a significant proportion of the population with some studies quoting rates of 5%. (1) Many techniques have been described over the years including, cartilage sparing, cartilage cutting, cartilage scoring and suturing.(2) Some of the more recent techniques describe the efficacy of incisionless pinnaplasty in selected cases. (2) Each technique has advantages and disadvantages with no overall consensus on the optimal technique. Pinnaplasty has several recognised complications including haematoma, infection, skin or cartilage necrosis, re-protrusion, asymmetry, suture expulsion and keloid scarring...
December 19, 2016: Clinical Otolaryngology
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