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Keloid

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https://www.readbyqxmd.com/read/29029852/human-adipose-tissue-derived-stem-cells-inhibit-the-activity-of-keloid-fibroblasts-and-fibrosis-in-a-keloid-model-by-paracrine-signaling
#1
Jianlan Liu, Jie Ren, Lina Su, Shimeng Cheng, Jing Zhou, Xiaolu Ye, Yabin Dong, Silei Sun, Fazhi Qi, Zhifei Liu, Jonathon Pleat, Hongjun Zhai, Ningwen Zhu
BACKGROUND: Human adipose tissue-derived mesenchymal stem cells (ASCs) have potential utility as modulators of the regeneration of tissue that is inflamed or scarred secondary to injuries such as burns or trauma. However, the effect of ASCs on one particular type of scarring, keloidal disease, remains unknown. The absence of an optimal model for investigation has hindered the development of an effective therapy using ASCs for keloids. OBJECTIVE: To investigate the influence of ASCs on angiogenesis, extracellular matrix deposition, and inflammatory cell influx in keloids...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29023993/pediatric-keloids-a-6-year-retrospective-review
#2
Afieharo I Michael, Samuel A Ademola, Olayinka A Olawoye, Ayodele O Iyun, Wasiu Adebayo, Odunayo M Oluwatosin
BACKGROUND/OBJECTIVES: Keloids are reportedly rare at the extremes of life. We sought to describe the epidemiology of pediatric keloids seen at the plastic surgery outpatient department of the University College Hospital, Ibadan. METHODS: We retrospectively reviewed all children younger than 19 years who presented with nonburn keloids between 2008 and 2014. Data were obtained on age; duration, size, and location of the keloid; family history; mode of treatment; and outcome...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29022793/intralesional-excision-with-topical-intralesional-cryotherapy-improves-the-treatment-of-keloid-scarring-in-a-paediatric-patient
#3
D Reissis, T Tickunas, R A Agha, Avh Greig
Recurrent keloid scarring has a significant impact on quality of life. Management is complex, particularly for scars resistant to conventional treatments and in paediatric cases where radiotherapy is not a suitable adjunct to surgical excision. We present the case of a nine-year-old African Caribbean girl with multiple large and recurrent keloid scars on both ears and bilateral sensorineural deafness. Following repeated intralesional excisions, corticosteroid and botulinum toxin injections, she continued to experience rapid recurrence of her keloids, worsening pain and pruritus...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29021584/mortalin-deficiency-suppresses-fibrosis-and-induces-apoptosis-in-keloid-spheroids
#4
Won Jai Lee, Hyo Min Ahn, Youjin Na, Renu Wadhwa, JinWoo Hong, Chae-Ok Yun
Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it's pro-proliferative and anti-apoptosis functions could be associated with keloid pathogenesis, and blocking of mortalin and its interaction with p53 might be a potential novel target for the treatment of keloid. Therefore, we generated mortalin-specific small hairpin (sh) RNAs (dE1-RGD/GFP/shMot) and introduced into keloid spheroids for examination of its apoptotic and anti-fibrotic effect. On keloid tissues, mortalin expression was higher than adjacent normal tissues and it's protein expressions were activated keloid fibroblasts (KFs)...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016541/a-novel-treatment-of-acne-keloidalis-nuchae-by-long-pulsed-alexandrite-laser
#5
Abeer Tawfik, Mai Abdelraouf Osman, Iman Rashwan
BACKGROUND: Acne keloidalis nuchae (AKN) is a dermatological condition characterized by follicular-based papules and pustules that later form hypertrophic or keloid-like scars. Laser-assisted hair reduction such as 810-nm diode laser and 1,064-nm Nd:YAG laser have been used for treating AKN with promising results. OBJECTIVE: To evaluate the therapeutic effect and safety of alexandrite laser in the treatment of different lesions of AKN. METHODS: Seventeen male patients with AKN received 6 sessions of 755-nm alexandrite laser...
October 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29016315/case-report-molecular-confirmation-of-lobomycosis-in-an-italian-traveler-acquired-in-the-amazon-region-of-venezuela
#6
Anna Beltrame, Patrizia Danesi, Claudio Farina, Pierantonio Orza, Francesca Perandin, Claudia Zanardello, Paola Rodari, Silvia Staffolani, Zeno Bisoffi
Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by Lacazia loboi, an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28988454/awake-serial-intralesional-steroid-injections-without-surgery-as-a-novel-targeted-treatment-for-idiopathic-subglottic-stenosis
#7
Ramon A Franco, Inna Husain, Lindsay Reder, Paul Paddle
OBJECTIVES/HYPOTHESIS: The fibrotic/erythematous appearance of the subglottis in idiopathic subglottic stenosis (iSGS) hints that it might respond to repeated intralesional steroid treatment similar to keloids. STUDY DESIGN: Retrospective cohort study. METHODS: Thirteen iSGS subjects (six treated in-office with serial intralesional steroid injections [SILSI] versus seven treated endoscopically in the operating room [OR] followed by awake SILSI) between October 2011 and April 2017...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28979658/radiation-therapy-for-the-adjunctive-treatment-of-surgically-excised-keloids-a-review
#8
REVIEW
Nikoo Cheraghi, Armand Cognetta, David Goldberg
BACKGROUND: Radiotherapy has been used historically to treat a wide variety of dermatologie conditions, including nonmelanoma skin cancers, lymphomas, and inflammatory skin conditions. Recently, radiotherapy has been used increasingly as a valuable tool in the postsurgical treatment of large or recalcitrant keloids. OBJECTIVE: The objective of this review was to explore the use of radiation therapy as an adjuvant to surgically excised keloids. DESIGN: A PubMed search of all published English literature regarding the applications of radiotherapy for the treatment of keloids was performed using a combination of keywords including radiation, radiotherapy, brachytherapy, electron beam, superficial radiation, orthovoltage radiation, and keloid...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28972447/target-specific-delivery-of-an-antibody-that-blocks-the-formation-of-collagen-deposits-in-skin-and-lung
#9
Jolanta Fertala, Freddy Romero, Ross Summer, Andrzej Fertala
Regardless of the cause of organ fibrosis, its main unwanted consequence is the formation of collagen fibril-rich deposits that hamper the structure and function of affected tissues. Although many strategies have been proposed for the treatment of fibrotic diseases, no therapy has been developed, which can effectively block the formation of collagen fibril deposits. With this in mind, we recently developed an antibody-based therapy to block key interactions that drive collagen molecules into fibrils. In this study, we analyzed target specificity, which is a main parameter that defines the safe use of all antibody-based therapies in humans...
October 3, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28966521/primary-cutaneous-endometriosis-of-umbilicus
#10
Seung-Hee Loh, Bark-Lynn Lew, Woo-Young Sim
Cutaneous endometriosis is defined by the presence of endometrial glands and/or stroma in skin and represents less than 1% of all ectopic endometrium. Cutaneous endometriosis is classified as primary and secondary. Primary cutaneous endometriosis appears without a prior surgical history and secondary cutaneous endometriosis mostly occurs at surgical scar tissue after abdominal operations. The most widely accepted pathogenesis of secondary endometriosis is the iatrogenic implantation of endometrial cells after surgery, such as laparoscopic procedures...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28954083/wade-s-histoid-leprosy-in-a-14-year-old-teenage-boy
#11
Renata Borges Fortes da Costa Figueira, Karen Fernandes de Oliveira, Luciana Borges de Souza, Gustavo Henrique Soares Takano, Jorgeth de Oliveira Carneiro da Motta, Izelda Maria Carvalho Costa
Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Furthermore, HL is rare in children and is difficult to diagnose even by experts. This report describes a case of HL in a 14-year-old Brazilian boy, who presented with multiple nodular and tumor-like lesions, simulating keloids...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28946730/the-rolling-earlobe-flap-for-dilated-ear-holes-following-ear-gauging-a-novel-approach-to-aesthetically-preserving-earlobe-soft-tissue-volume
#12
Wan-Sze Pek, Lin Hon Terence Goh, Chong Han Pek
Patients are increasingly seeking repair of their earlobes following ear gauging. Research has shown that current repair techniques either excessively reduce the lobular volume or leave an obvious scar along the free edge of the earlobe. In our case series, we describe the use of a novel technique for repairing earlobes following ear gauging using a rolling earlobe flap that preserves the lobular volume and avoids leaving a scar on the free edge of the lobule. The procedure was performed on 3 patients (6 earlobes) who had defects from ear gauging that ranged from 3...
September 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28946718/effects-of-topical-tamoxifen-on-wound-healing-of-burned-skin-in-rats
#13
Shaban Mehrvarz, Ali Ebrahimi, Hedayat Sahraei, Mohammad Hasan Bagheri, Sima Fazili, Shahram Manoochehry, Hamid Reza Rasouli
BACKGROUND: This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue. METHODS: Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring 2×2×2 cm. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks...
September 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28946191/tmem88-inhibits-extracellular-matrix-expression-in-keloid-fibroblasts
#14
Huafei Zhao, Fei Lu, Shuo Cui, Xinying Zhang, Weixin Wang, Enze Si, Zhengjiang Yuan
Keloid is characterized by hyper-proliferation of fibroblasts and excess extracellular matrix (ECM) deposition. Transmembrane protein 88 (TMEM88), belonging to the TMEM family, was involved in the regulation of tumorigenesis and fibrogenesis. However, the role of TMEM88 in keloid formation remains unclear. This study aimed to investigate the effects of TMEM88 on keloid-derived fibroblasts (KFs) proliferation and ECM expression, and explore the underlying mechanism. Our results demonstrated that TMEM88 was lowly expressed in human keloid tissues and TGF-β1-stimulated KFs...
September 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28941494/current-understanding-of-the-genetic-causes-of-keloid-formation
#15
REVIEW
Donald A Glass
Keloids are an exuberant response to cutaneous wound healing. Several lines of evidence suggest that keloid scarring is influenced by genetic factors. This review will discuss our current understanding of genetic influences on keloidal scarring via familial inheritance patterns; ethnic differences in prevalence; syndromes with keloid occurrence; linkage analysis, genome-wide association studies, and admixture mapping studies; transforming growth factor beta and p53 variant studies; and human leukocyte antigen polymorphisms...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941489/from-bench-to-bedside-the-hampton-university-skin-of-color-research-institute-2015-skin-of-color-symposium
#16
EDITORIAL
Clinton W Enos, Valerie M Harvey
The Hampton University Skin of Color Research Institute Skin of Color Symposium 2015: From Bench to Bedside was held in Williamsburg, Virginia at the Williamsburg Lodge, November 13-15, 2015. The conference was designed to promote, develop, and advance the education, knowledge, and research of cutaneous disorders disproportionately affecting people of racial and ethnic minority groups. Centered on the theme of "From Bench to Bedside", the symposium provided a program featuring a diverse panel of nationally recognized physician-scientists, basic scientists, and clinicians who updated attendees on the latest research advances across multiple relevant disciplines, including public health, basic science, and the clinical diagnosis and management of select complex and rare dermatologic conditions...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28932067/extensive-donor-site-keloids-in-follicular-unit-extraction-hair-transplantation
#17
Shimona Garg, Anand Kumar, Ankita Tuknayat, Gurvinder Pal Thami
Hair transplantation, a generally regarded as a safe surgical modality for the treatment of androgenetic alopecia, is not without its potential risks and complications. A case of an extensive keloid formation at donor site following follicular unit extraction is discussed. Hair transplant surgeons should be aware of this significant potential complication, especially in patients having previous keloidal tendencies to avoid such disastrous outcomes.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932061/epidermal-cysts-a-clinicopathological-analysis-with-emphasis-on-unusual-findings
#18
Jitendra Singh Nigam, Jyotsna Naresh Bharti, Vivek Nair, Chitrawati Bal Gargade, Archana Hemant Deshpande, Biswajit Dey, Ashok Singh
BACKGROUND: Epidermoid cysts, one of the common benign intradermal or subcutaneous tumors commonly result from the trauma to the pilosebaceous unit in the hair bearing area. In areas without hair, these cysts are considered implantation and proliferation of squamous epithelium into the dermis due to injury. AIMS: The aim is to evaluate the clinicopathological details with emphasis on unusual findings related to epidermoid cysts. STUDY DESIGN: This is a retrospective cross-sectional study carried out over 2 years...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28920474/the-state-of-ethnic-dermatology-in-canada
#19
Boluwaji Ogunyemi, Yvette Miller-Monthrope
Approximately 30% of Canadians will be members of a visible minority by 2031. When dermatology became an independent medical discipline in the late 18th and early 19th centuries, most residents of Canada and the United States were of Northern European descent. Morphology and descriptions of dermatoses are based on patients with light skin. Skin of colour dermatology refers to a unique field in dermatology dedicated to the diagnosis and management of disorders that are more prevalent in patients with moderately to richly pigmented skin...
September 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28915288/successful-treatment-of-keloid-with-fractionated-carbon-dioxide-co2-laser-and-laser-assisted-drug-delivery-of-triamcinolone-acetonide-ointment-in-an-african-american-man
#20
Ekaterina Kraeva, Derek Ho, Jared Jagdeo
Keloids are fibrous growths that occur as a result of abnormal response to dermal injury. Keloids are cosmetically disfiguring and may impair function, often resulting in decreased patient quality-of-life. Treatment of keloids remains challenging, and rate of recurrence is high. We present a case of a 39-year-old African-American man (Fitzpatrick VI) with a 10-year history of keloid, who was successfully treated with eight sessions of fractionated carbon dioxide (CO2) laser immediately followed by laser-assisted drug delivery (LADD) of topical triamcinolone acetonide (TAC) ointment and review the medical literature on fractionated CO2 laser treatment of keloids...
September 1, 2017: Journal of Drugs in Dermatology: JDD
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