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Yiqun Sun, Haiyang Jiang, Ming Gu, Xinyu Zheng
Keloid scarring is a type of fibroproliferative disease with a high recurrence rate. However, no effective treatment is currently available. Combined therapy with recombinant lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase (Dm‑dNK) and prodrug has been widely studied and used for cancer treatment. Due to the similarities between keloid scars and tumors, the aim of the present study was to investigate the efficacy of a Dm‑dNK/nucleoside analog system for the treatment of keloid scars...
May 30, 2018: Molecular Medicine Reports
Simona Stolnicu, Alexandra Giurgi, Adrian Naznean, Cristian Podoleanu, Anca Chiriac
We present a very rare case of an adenosquamous infiltrating breast carcinoma with sarcomatous stromal overgrowth of hypocellular collagenised type, which subsequently developed local recurrence, mistaken for a benign skin lesion due to bland keloid-like morphological appearance. All the histological, immunohistochemical, and clinical features must be taken into consideration when distinguishing between a benign skin lesion and a local recurrence of a rare subtype of breast carcinoma.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Robabeh Abedini, Pardis Sasani, Hamid Reza Mahmoudi, Maryam Nasimi, Amir Teymourpour, Zahra Shadlou
BACKGROUND: Keloids and hypertrophic scars are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems. METHODS: In this randomized controlled trial, with a paired design, 50 patients with 2 or more keloids were included. In the control group (50 lesions), intralesional triamcinolone acetonide (40mg/mL) was injected at three-week intervals for a total of 18weeks. In the other group (50 lesions), lesions were treated by verapamil (2...
June 6, 2018: Burns: Journal of the International Society for Burn Injuries
Zhenyu Zhang, Lihui Cheng, Ru Wang, Ying Cen, Zhengyong Li
Background: Triamcinolone acetonide (TAC) is used frequently in the treatment of keloid scars, but has presented controversial results. In this study, we aim to evaluate the effectiveness of TAC compared with other common therapies used in keloid treatment. Methods: MEDLINE, Embase, Web of Science and the Cochrane Library databases were searched until January 2018. Key data were extracted from eligible randomized controlled trials. Both pairwise and network meta-analyses were conducted for synthesizing data from eligible studies...
2018: Therapeutics and Clinical Risk Management
Pirabu Sakthivel, Chirom Amit Singh
No abstract text is available yet for this article.
2018: Pan African Medical Journal
Alexandros Onoufriadis, Chao-Kai Hsu, Chrysanthi Ainali, Chuin Ying Ung, Ellie Rashidghamat, Hsing-San Yang, Hsin-Yu Huang, Umar Niazi, Christos Tziotzios, Jui-Chu Yang, Rosamond Nuamah, Ming-Jer Tang, Alka Saxena, Emanuele de Rinaldis, John A McGrath
No abstract text is available yet for this article.
June 2, 2018: Journal of Investigative Dermatology
Lianbo Zhang, Haiyan Qin, Zhuoxia Wu, Wanying Chen, Guang Zhang
BACKGROUND: We aimed to explore potential molecular basis of keloid formation and response mechanism of keloid to hydrocortisone (HC). METHODS: Transcriptional profile of GSE7890 which contained 5 normal scar with no HC treatment (NNHC), 4 normal scar treated with HC (NHC), 5 keloid with no HC treatment (KNHC) and 5 keloid treated with HC (KHC) samples was downloaded to identify differentially expressed genes (DEGs). Based on DEGs, hierarchical cluster analysis and pathway enrichment analysis were performed...
June 4, 2018: Journal of Dermatological Treatment
Michelangelo Vestita, Angela Filoni, Nicola Arpaia, Grazia Ettorre, Domenico Bonamonte
Proteus syndrome (PS) is a postnatal mosaic overgrowth disorder, progressive and disfiguring. It is clinically diagnosed according to the criteria reported by Biesecker et al . We describe the case of a 49-year-old woman who presented with a 10-year history of pauci-symptomatic infiltrating plaque lesions on the sole and lateral margin of the left foot, which had been diagnosed as a keloid. The patient had a positive history for advanced melanoma and a series of subtle clinical signs, such as asymmetric face, scoliosis, multiple lipomas on the trunk, linear verrucous epidermal nevi, and hyperpigmented macules with a mosaic distribution...
2018: F1000Research
Fawad Aslam, Jonathan A Flug, Yousif Yonan, Shelley S Noland
Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease), penile fibromatosis (Peyronie's disease), knuckle pads, and keloids. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. We report one such case and review the existing literature on this rare syndrome.
2018: Case Reports in Rheumatology
Won Jai Lee, Seung Yong Song, Hyun Roh, Hyo Min Ahn, Youjin Na, Jihee Kim, Ju Hee Lee, Chae Ok Yun
High-mobility group box 1 (HMGB1) protein acts as a DNA chaperone for nuclear homeostasis. It translocates into the cytosol and is secreted into extracellular spaces, triggering proinflammatory cytokines and acting as a mediator in fibrosis. We determined whether HMGB1 plays a role in normal dermal fibrosis and keloid, and is involved with transforming growth factor β. We investigated the translocation and active release of HMGB1 from normal dermal fibroblasts under lipopolysaccharide stimuli, and the redistribution of nuclear HMGB1 into the cytoplasm of keloid fibroblasts...
May 30, 2018: Scientific Reports
Yi-Xuan Zhao, Chia-Kang Ho, Yun Xie, Ya-Hong Chen, Hai-Zhou Li, Guo-You Zhang, Qing-Feng Li
Recent researches have indicated that S100A4 participates in tissue fibrosis, whereas calcimycin inhibits this process as a novel S100A4 transcription inhibitor. However, the relationship and mechanisms between calcimycin and S100A4 in keloid fibroblasts (KFs) remain unknown. The present research was aimed to evaluate the effect of calcimycin on S100A4 expression and pathogenesis in KFs. Keloid fibroblasts were cultured and exposed to different concentrations of calcimycin in the absence or presence of transforming growth factor β1 (TGF-β1)...
May 24, 2018: Annals of Plastic Surgery
Ye Zhang, Bingyu Guo, Qiang Hui, Wei Li, Peng Chang, Kai Tao
Keloids are a type of abnormal scar tissue. MicroRNAs (miRNAs) exhibit a pivotal role in the regulation of cell proliferation and metastasis of keloids. miRNA microarray revealed that miR‑637 was one of the most frequently altered miRNAs in keloids. Furthermore, up-regulation of miR‑637 inhibited cell proliferation and metastasis by targeting mothers against decapentaplegic homolog (Smad)3, one of the important proteins that affects the formation of keloids. Further studies demonstrated that miR‑637 regulated the proliferation and metastasis of human keloid fibroblast (HKF) cells by mediating the Smad3 signaling pathway...
May 29, 2018: Molecular Medicine Reports
Okuno Ryoko, Yuko Ito, Nabil Eid, Yoshinori Otsuki, Yoichi Kondo, Koichi Ueda
Keloid is a fibro-proliferative skin disorder with tumor-like behavior and dependence on anaerobic glycolysis (the Warburg effect), but its exact pathogenesis is unknown. Although autophagy is widely accepted as a lysosomal pathway for cell survival and cellular homeostasis (specifically upon exposure to stressors such as hypoxia), very few studies have investigated the involvement of autophagy and related glycolytic effectors in keloidogenesis. Here the authors examined the expression and cellular localization of autophagy proteins (LC3, pan-cathepsin), glycolytic markers (LDH, MCT1, MCT4) and the transcription factor HIF isoforms in human keloid samples using immunohistochemical analysis and double-labeling immunofluorescence methods...
May 29, 2018: Histology and Histopathology
Giacomo Fiacchini, Niccolò Cerchiai, Domenico Tricò, Stefano Sellari-Franceschini, Augusto Pietro Casani, Iacopo Dallan, Veronica Seccia
PURPOSE: Parotidectomy may be burdened by numerous complications that may worsen subjects' quality of life (QoL). These include paresis or paralysis of the facial nerve, face profile asymmetry, keloids, salivary fistula, Frey Syndrome (FS), First Bite Syndrome (FBS), and hypo-anaesthesia of the skin. This study is an effort to assess the incidence of complications following parotidectomy and their impact on subjects' QoL. METHODS: Subjects undergoing parotidectomy for benign neoplasms from 2012 to 2015 were selected and invited to attend our outpatient clinic...
May 26, 2018: European Archives of Oto-rhino-laryngology
Alexander W Pastuszak, Katherine M Rodriguez, Zachary J Solomon, Taylor P Kohn, Larry I Lipshultz, Michael L Eisenberg
BACKGROUND: The subsequent health risks associated with Peyronie's disease (PD) are unknown. AIM: This cohort study assesses the risk of developing auto-immune conditions and common chronic health conditions after a diagnosis of PD. We hypothesize that an increase in auto-immune disease will be evident in men with PD, as has been suggested in smaller studies. METHODS: We determined the longitudinal incidence of 13 auto-immune diseases and 25 common chronic conditions in a cohort from the Truven Health Analytics (Ann Arbor, Michigan, USA) database from 2007-2013...
June 2018: Journal of Sexual Medicine
Fares Salameh, Amir Koren, Eli Sprecher, Ofir Artzi
BACKGROUND: Current approaches use subjective semiquantitative or cumbersome objective methodologies to assess physical characteristics of hypertrophic and keloid scars. OBJECTIVE: This pilot study aimed to evaluate the accuracy and feasibility of a new stereoscopic optical and high-resolution 3-dimensional imaging system, for objectively measuring changes in above-surface scar volume after various interventions. METHODS: Feasibility and accuracy were assessed by monitoring the above-surface scar volume of 5 scars in 2 patients for 5 successive months...
June 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
X F Qiao, X Li
Objective: To evaluate the clinical effect of auricular keloids resection combined with local injection of glucocorticoid and superficial X-ray treatment in order to identify a surgery-based, personalized, comprehensive treatment system. Method: One hundred and sixty patients with auricular keloids were divided into four groups: surgery group, surgery combined with local injection of glucocorticoid group, surgery combined with superficial X-ray group and surgery combined with glucocorticoid and electron irradiation group (Triple therapy group)...
September 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Dustin Taylor, Natalie Kash, Sirunya Silapunt
Lymphangioma circumscriptum is a superficially localized variant of lymphangioma. The characteristic clinical presentation is a "frogspawn" grouping of vesicles or papulovesicles on the proximal limb or limb girdle areas. Though most lymphangiomas develop congenitally, the lymphangioma circumscriptum subtype is known to present in adults. We report a case of lymphangioma circumscriptum on the left inframammary area of an African American female with an unusual supernumerary nipple-like clinical presentation...
2018: Case Reports in Dermatological Medicine
Geoffroy de Beco, Natasha Mambour, Christophe Vô, Laetitia Vanhoutte, Stéphane Moniotte, Alain Poncelet, Thierry Sluysmans
While percutaneous catheter closure proves an effective treatment for secundum atrial septal defect (ASD2), some child patients require surgical closure. We assessed the risks associated with isolated surgical ASD2 closure by reviewing the outcomes of 120 children operated on between 1999 and 2011 (mean age 4.6 ± 3.9 years, mean weight 17 ± 12 kg). Direct sutures were performed in 4% and patch closures in 96%. The mean cardiopulmonary bypass duration was 38 ± 14 min, aortic cross-clamp time 19 ± 9 min, intensive care unit length of stay 1...
May 22, 2018: Pediatric Cardiology
Anne-Sophie Florczak, Benoit Chaput, Christian Herlin, Pascal Rousseau, Eric Watier, Nicolas Bertheuil
BACKGROUND: In recent years, pedicled perforator flaps have revolutionized plastic surgery by reducing donor site morbidity and ensuring larger and deeper reconstructions with local pedicled cutaneous flaps. The aim of the study was to make a systematic review of perforator pedicled propeller flaps (PPPFs) in chest reconstruction. METHODS: Pubmed and Cochrane databases were searched from 1989 to October 2016 for articles describing the use of PPPFs in chest reconstruction...
May 17, 2018: Annals of Plastic Surgery
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