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https://www.readbyqxmd.com/read/27909969/subjective-ulnar-nerve-dysfunction-commonly-following-open-reduction-internal-fixation-orif-of-distal-humeral-fractures-and-in-situ-decompression-of-the-ulnar-nerve
#1
Birgitta Svernlöv, Jens Nestorson, Lars Adolfsson
The aim of this retrospective study was to investigate the frequency of persistent ulnar affection in patients who underwent open reduction and internal fixation (ORIF) of distal humeral fractures without ulnar nerve transposition or mobilisation. Eighty-two patients (53 women), mean age 62 years, were, at a mean of 48 months, reviewed through medical records and a subjective evaluation form concerning ulnar nerve problems. Ulnar nerve affliction, in most cases regarded as mild, was experienced by 22 patients (27%; 14 women) and significantly associated with multiple surgeries...
December 1, 2016: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/27909582/ebola-research-funding-a-systematic-analysis-1997-2015
#2
Joseph Ra Fitchett, Amos Lichtman, Damilola T Soyode, Ariel Low, Jimena Villar de Onis, Michael G Head, Rifat Atun
BACKGROUND: The latest outbreak of Ebola in West Africa overwhelmed the affected countries, with the impact on health extending far beyond Ebola-related deaths that have exceeded 11 000. The need to promptly mobilise resources to control emerging infections is widely recognized. Yet, data on research funding for emerging infections remains inadequately documented. METHODS: We defined research investment as all funding flows for Ebola and/or Marburg virus from 1997 to April 2015 whose primary purpose was to advance knowledge and new technologies to prevent or cure disease...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27908478/-nurses-mobilised-in-screening-for-osteoporosis
#3
REVIEW
Martine Maville, Grégoire Cormier, Stéphanie Rabiller, Jérôme Dimet, Céline Cozic
The consequences of an osteoporotic fracture are often harmful. The teams of La Roche-sur-Yon general hospital have created a primary and secondary screening programme led by a nurse. Hospitalised female patients between the ages of 50 and 80 are screened for osteoporosis risk factors.
December 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/27903633/an-e2-guided-e3-screen-identifies-the-rnf17-ube2u-pair-as-regulator-of-the-riddle-syndrome-protein-rnf168
#4
Yingying Guo, Liwei An, Hoi-Man Ng, Shirley M H Sy, Michael S Y Huen
Protein ubiquitination has emerged as pivotal regulatory reactions that promote cellular responses to DNA damage. With a goal to delineate the DNA damage signal transduction cascade, we systematically analysed the human E2 ubiquitin and ubiquitin-like conjugating enzymes for their ability to mobilise the DNA damage marker 53BP1 onto IR-induced DNA double-strand breaks (DSBs). RNAi-based screen identified UBE2U as a candidate regulator of chromatin responses at DSBs. Further mining of the UBE2U interactome uncovered its cognate E3 RNF17 as a novel factor that, via the Riddle syndrome protein RNF168, enforces DNA damage responses...
November 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27903429/polyhydroxyalkanoate-as-a-slow-release-carbon-source-for-in-situ-bioremediation-of-contaminated-aquifers-from-laboratory-investigation-to-pilot-scale-testing-in-the-field
#5
Lucia Pierro, Bruna Matturro, Simona Rossetti, Marco Sagliaschi, Salvatore Sucato, Eduard Alesi, Ernst Bartsch, Firoozeh Arjmand, Marco Petrangeli Papini
A pilot-scale study aiming to evaluate the potential use of poly-3-hydroxy-butyrate (PHB) as an electron donor source for in situ bioremediation of chlorinated hydrocarbons in groundwater was conducted. Compared with commercially available electron donors, PHB offers a restricted fermentation pathway (i.e., through acetic acid and molecular hydrogen) by avoiding the formation of any residual carbon that could potentially spoil groundwater quality. The pilot study was carried out at an industrial site in Italy, heavily contaminated by different chlorinated aliphatic hydrocarbons (CAHs)...
November 26, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27902415/inversion-of-correia-repeat-enclosed-elements-in-neisseria-gonorrhoeae
#6
Firat Elbeyioglu, Sabrina B Roberts, Russell Spencer-Smith, Madhuri Pulijala, Marta A Zelewska, Jean-Christophe Nebel, Lori As Snyder
Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Within the gonococcal genome are over 100 copies of the IS-like Correia Repeat Enclosed Element, which has been predicted to be mobile within the neisserial genomes. Although there is evidence of ancestral movement of these elements, no previous study has provided evidence for current mobilisation. The Correia Repeat Enclosed Element has the ability to alter gene expression and regulation in many ways: by insertional mutagenesis; by introducing promoter elements; by generating mRNA processing sites, and by association with ncRNAs...
November 16, 2016: Microbiology
https://www.readbyqxmd.com/read/27895835/reflections-on-the-first-twenty-five-years-of-the-university-of-malawi-college-of-medicine
#7
Adamson S Muula, Wakisa Mulwafu, Diston Chiweza, Ronald Mataya
September 2016 marks 25 years since the College of Medicine of the University of Malawi was established. In this article we reflect on its conception, birth, adolescence, and youth. The contributions of multiple stakeholders are celebrated while being mindful of the ongoing efforts to consolidate past and current gains. For instance, the College of Medicine was, until recently, the only medical school in the country, but a new private medical school has just been opened in Lilongwe. International partnerships and wide-ranging resource mobilisation from both internal and international funders has been the hallmark of the growth and expansion of the Malawi College of Medicine...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27890544/persistent-hydrocephalus-due-to-postural-activation-of-a-ventricular-shunt-anti-gravity-device
#8
Claudia L Craven, Ahmed K Toma, Laurence D Watkins
The ever present need to balance over drainage with under drainage in hydrocephalus has required innovations including adjustable valves with antigravity devices. These are activated in the vertical position to prevent siphoning. We describe a group of bedridden patients who presented with unexplained under drainage caused by activation of antigravity shunt components produced by peculiar head/body position. Retrospective single centre case series of hydrocephalus patients, treated with ventriculo-peritoneal (VP) shunt insertion between April 2014 - February 2016...
November 24, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27890045/protein-in-culture-and-endogenous-lipid-interact-with-embryonic-stages-in-vitro-to-alter-calf-birthweight-after-embryo-vitrification-and-warming
#9
E Gómez, S Carrocera, S Uzbekova, D Martín, A Murillo, M Alonso-Guervós, F Goyache, M Muñoz
Short-term protein removal in vitro improves long-term blastocyst competence to survive vitrification. We investigated the mechanisms and effects underlying protein removal. Day-6 morulae and early blastocysts were cultured individually with and without protein for 24h. Development and lipid content were analysed in expanded blastocysts derived from morulae (M-XB) and from early blastocysts (EB-XB). Expression of genes involved in lipid metabolism, stress responses and apoptosis was analysed in fresh and vitrified-warmed M-XB produced with and without protein...
November 28, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27881867/endothelial-cell-colony-forming-units-derived-from-malignant-breast-diseases-are-resistant-to-tumor-necrosis-factor-%C3%AE-induced-apoptosis
#10
Chen-Pin Chou, Shih Sheng Jiang, Huay-Ben Pan, Yi-Chen Yen, Hui-Hwa Tseng, Yu-Ting Hung, Ssu-Han Wang, Yu-Lin Chen, Ya-Wen Chen
Mobilisation of endothelial progenitor cells (EPCs) from the bone marrow is a crucial step in the formation of de novo blood vessels, and levels of peripheral blood EPCs have been shown to be elevated in certain malignant states. Using flow cytometry and a Hill-based colony forming unit (CFU) assay, the present study indicated that higher levels of CD34 and vascular endothelial growth factor receptor 2 (VEGFR2) double-positive EPCs, as well as increased formation of endothelial cell colony-forming units (EC-CFUs) are associated with benign and malignant breast diseases, providing possible indicators for breast disease detection...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881152/fitness-and-mobility-training-in-patients-with-intensive-care-unit-acquired-muscle-weakness-fitonicu-study-protocol-for-a-randomised-controlled-trial
#11
Jan Mehrholz, Simone Thomas, Jane H Burridge, André Schmidt, Bettina Scheffler, Ralph Schellin, Stefan Rückriem, Daniel Meißner, Katja Mehrholz, Wolfgang Sauter, Ulf Bodechtel, Bernhard Elsner
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP) are a common complication of critical illness. Both cause intensive-care-unit-acquired (ICU-acquired) muscle weakness (ICUAW) which increases morbidity and delays rehabilitation and recovery of activities of daily living such as walking ability. Focused physical rehabilitation of people with ICUAW is, therefore, of great importance at both an individual and a societal level. A recent systematic Cochrane review found no randomised controlled trials (RCT), and thus no supporting evidence, for physical rehabilitation interventions for people with defined CIP and CIM to improve activities of daily living...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27878879/classificatory-multiplicity-intimate-partner-violence-diagnosis-in-emergency-department-consultations
#12
Philippa Olive
AIMS AND OBJECTIVES: The aim of this research was to explore the naming, or classification, of physical assaults by a partner as 'intimate partner violence' during emergency department consultations. BACKGROUND: Research continues to evidence instances when intimate partner physical violence is 'missed' or unacknowledged during emergency department consultations. METHODS: Theoretically this research was approached through complexity theory and the sociology of diagnosis...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27871284/radiographic-results-after-plaster-cast-fixation-for-10%C3%A2-days-versus-1%C3%A2-month-in-reduced-distal-radius-fractures-a-prospective-randomised-study
#13
Albert Christersson, Sune Larsson, Bengt Östlund, Bengt Sandén
BACKGROUND: The aim of this study was to examine whether reduced distal radius fractures can be treated with early mobilisation without affecting the radiographic results. METHODS: In a prospective randomised study, 109 patients (mean age 65.8 (range 50-92)) with moderately displaced distal radius fractures were treated with closed reduction and plaster cast fixation for about 10 days (range 8-13 days) followed by randomisation to one of two groups: early mobilisation (n = 54, active group) or continued plaster cast fixation for another 3 weeks (n = 55, control group)...
November 21, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27867509/comparison-of-fentanyl-iontophoretic-transdermal-system-and-routine-care-with-morphine-intravenous-patient-controlled-analgesia-in-the-management-of-early-postoperative-mobilisation-results-from-a-randomised-study
#14
Richard M Langford, Kuang-Yi Chang, Li Ding, Jeffrey Abraham
INTRODUCTION: Fentanyl iontophoretic transdermal system (ITS) (IONSYS(®), The Medicines Company, Parsippany, NJ, USA) and morphine intravenous (IV) patient-controlled analgesia (PCA) have demonstrated equivalent pain control in several published studies. The primary objective of the current study was to compare fentanyl ITS with morphine IV PCA with regard to the patient's ability to mobilise with acute postoperative pain. METHODS: In this multicentre, open-label, randomised, active-controlled, prospective phase IV study, postoperative patients initially received IV morphine and were titrated to pain score ⩽ 4out of 10 on a Numeric Rating Scale (NRS) and then received fentanyl ITS (up to 240 µg (6 doses)/hour; up to a maximum of 3...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27864615/the-effects-of-active-mobilisation-and-rehabilitation-in-icu-on-mortality-and-function-a-systematic-review
#15
REVIEW
Claire J Tipping, Meg Harrold, Anne Holland, Lorena Romero, Travis Nisbet, Carol L Hodgson
PURPOSE: Early active mobilisation and rehabilitation in the intensive care unit (ICU) is being used to prevent the long-term functional consequences of critical illness. This review aimed to determine the effect of active mobilisation and rehabilitation in the ICU on mortality, function, mobility, muscle strength, quality of life, days alive and out of hospital to 180 days, ICU and hospital lengths of stay, duration of mechanical ventilation and discharge destination, linking outcomes with the World Health Organization International Classification of Function Framework...
November 18, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27858140/adipocyte-stat5-deficiency-promotes-adiposity-and-impairs-lipid-mobilisation-in-mice
#16
Doris Kaltenecker, Kristina M Mueller, Pia Benedikt, Ursula Feiler, Madeleine Themanns, Michaela Schlederer, Lukas Kenner, Martina Schweiger, Guenter Haemmerle, Richard Moriggl
AIMS/HYPOTHESIS: Dysfunction of lipid metabolism in white adipose tissue can substantially interfere with health and quality of life, for example in obesity and associated metabolic diseases. Therefore, it is important to characterise pathways that regulate lipid handling in adipocytes and determine how they affect metabolic homeostasis. Components of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway are involved in adipocyte physiology and pathophysiology...
November 17, 2016: Diabetologia
https://www.readbyqxmd.com/read/27844179/-it-s-making-contacts-notions-of-social-capital-and-implications-for-widening-access-to-medical-education
#17
S Nicholson, J A Cleland
In the UK widening access (WA) activities and policies aim to increase the representation from lower socio-economic groups into Higher Education. Whilst linked to a political rhetoric of inclusive education such initiatives have however failed to significantly increase the number of such students entering medicine. This is compounded by a discourse that portrays WA applicants and students as lacking the essential skills or attributes to be successful in medical education. Much of the research in this area to date has been weak and it is critical to better understand how WA applicants and students negotiate medical admissions and education to inform change...
November 14, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27843499/evidence-for-l1-associated-dna-rearrangements-and-negligible-l1-retrotransposition-in-glioblastoma-multiforme
#18
Patricia E Carreira, Adam D Ewing, Guibo Li, Stephanie N Schauer, Kyle R Upton, Allister C Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R Richardson, Bo Li, Daniel J Gerhardt, Jun Wang, Paul M Brennan, Geoffrey J Faulkner
BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours and neural cells but, paradoxically, not in brain cancers. RESULTS: Here, using retrotransposon capture sequencing (RC-seq), we surveyed L1 mutations in 14 tumours classified as glioblastoma multiforme (GBM) or as a lower grade glioma...
2016: Mobile DNA
https://www.readbyqxmd.com/read/27836993/diacylglycerol-acyltransferase-2-dgat2-links-glucose-utilization-to-fatty-acid-oxidation-in-the-brown-adipocytes
#19
Zehra Irshad, Federica Dimitri, Mark Christian, Victor A Zammit
Brown adipose tissue uptake of glucose and fatty acids is very high during non-shivering thermogenesis. Adrenergic stimulation markedly increases glucose uptake, de novo lipogenesis and FA oxidation simultaneously. The mechanism that enables this concerted response has hitherto been unknown. Here we find that in a primary brown adipocytes and brown adipocyte-derived cell line (IMBAT-1) acute inhibition and longer-term knockdown of DGAT2 links the increased de novo synthesis of fatty acids from glucose to a pool of TG which is simultaneously hydrolysed, providing FA for mitochondrial oxidation...
November 11, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27836136/essential-requirements-for-catchment-sediments-to-have-ongoing-impacts-to-water-clarity-in-the-great-barrier-reef
#20
Mark T Gibbs
Increasing concerns over decreasing water quality and the state of coral reefs and seagrass meadows along the inshore and mid-shelf regions of the Great Barrier Reef has led to a large-scale government catchment sediment and nutrient reduction program. However the mechanistic understanding of how fine sediments washed out of catchments and transported within flood plumes leads to ongoing increases in turbidity at locations far downstream from estuaries long after flood plumes have dissipated is poorly understood...
November 8, 2016: Marine Pollution Bulletin
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