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Early mobilisation

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https://www.readbyqxmd.com/read/27909582/ebola-research-funding-a-systematic-analysis-1997-2015
#1
Joseph Ra Fitchett, Amos Lichtman, Damilola T Soyode, Ariel Low, Jimena Villar de Onis, Michael G Head, Rifat Atun
BACKGROUND: The latest outbreak of Ebola in West Africa overwhelmed the affected countries, with the impact on health extending far beyond Ebola-related deaths that have exceeded 11 000. The need to promptly mobilise resources to control emerging infections is widely recognized. Yet, data on research funding for emerging infections remains inadequately documented. METHODS: We defined research investment as all funding flows for Ebola and/or Marburg virus from 1997 to April 2015 whose primary purpose was to advance knowledge and new technologies to prevent or cure disease...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27890045/protein-in-culture-and-endogenous-lipid-interact-with-embryonic-stages-in-vitro-to-alter-calf-birthweight-after-embryo-vitrification-and-warming
#2
E Gómez, S Carrocera, S Uzbekova, D Martín, A Murillo, M Alonso-Guervós, F Goyache, M Muñoz
Short-term protein removal in vitro improves long-term blastocyst competence to survive vitrification. We investigated the mechanisms and effects underlying protein removal. Day-6 morulae and early blastocysts were cultured individually with and without protein for 24h. Development and lipid content were analysed in expanded blastocysts derived from morulae (M-XB) and from early blastocysts (EB-XB). Expression of genes involved in lipid metabolism, stress responses and apoptosis was analysed in fresh and vitrified-warmed M-XB produced with and without protein...
November 28, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27871284/radiographic-results-after-plaster-cast-fixation-for-10%C3%A2-days-versus-1%C3%A2-month-in-reduced-distal-radius-fractures-a-prospective-randomised-study
#3
Albert Christersson, Sune Larsson, Bengt Östlund, Bengt Sandén
BACKGROUND: The aim of this study was to examine whether reduced distal radius fractures can be treated with early mobilisation without affecting the radiographic results. METHODS: In a prospective randomised study, 109 patients (mean age 65.8 (range 50-92)) with moderately displaced distal radius fractures were treated with closed reduction and plaster cast fixation for about 10 days (range 8-13 days) followed by randomisation to one of two groups: early mobilisation (n = 54, active group) or continued plaster cast fixation for another 3 weeks (n = 55, control group)...
November 21, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27867509/comparison-of-fentanyl-iontophoretic-transdermal-system-and-routine-care-with-morphine-intravenous-patient-controlled-analgesia-in-the-management-of-early-postoperative-mobilisation-results-from-a-randomised-study
#4
Richard M Langford, Kuang-Yi Chang, Li Ding, Jeffrey Abraham
INTRODUCTION: Fentanyl iontophoretic transdermal system (ITS) (IONSYS(®), The Medicines Company, Parsippany, NJ, USA) and morphine intravenous (IV) patient-controlled analgesia (PCA) have demonstrated equivalent pain control in several published studies. The primary objective of the current study was to compare fentanyl ITS with morphine IV PCA with regard to the patient's ability to mobilise with acute postoperative pain. METHODS: In this multicentre, open-label, randomised, active-controlled, prospective phase IV study, postoperative patients initially received IV morphine and were titrated to pain score ⩽ 4out of 10 on a Numeric Rating Scale (NRS) and then received fentanyl ITS (up to 240 µg (6 doses)/hour; up to a maximum of 3...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27864615/the-effects-of-active-mobilisation-and-rehabilitation-in-icu-on-mortality-and-function-a-systematic-review
#5
REVIEW
Claire J Tipping, Meg Harrold, Anne Holland, Lorena Romero, Travis Nisbet, Carol L Hodgson
PURPOSE: Early active mobilisation and rehabilitation in the intensive care unit (ICU) is being used to prevent the long-term functional consequences of critical illness. This review aimed to determine the effect of active mobilisation and rehabilitation in the ICU on mortality, function, mobility, muscle strength, quality of life, days alive and out of hospital to 180 days, ICU and hospital lengths of stay, duration of mechanical ventilation and discharge destination, linking outcomes with the World Health Organization International Classification of Function Framework...
November 18, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27826018/analysis-of-pcerc7-a-small-antibiotic-resistance-plasmid-from-a-commensal-st131-escherichia-coli-defines-a-diverse-group-of-plasmids-that-include-various-segments-adjacent-to-a-multimer-resolution-site-and-encode-the-same-nika-relaxase-accessory-protein-enabling
#6
Robert A Moran, Ruth M Hall
The ampicillin resistance plasmid pCERC7, carrying transposon Tn2 with an IS4 insertion, was detected in the draft genome of a commensal Escherichia coli isolate. The genome data also revealed that this isolate belongs to ST131, clade B. pCERC7 is 9712bp comprised of a 3319bp backbone, Tn2::IS4 (6388bp) and 5bp of target site duplication, and was present at a copy number of 40. pCERC7 is related to several plasmids composed of only the backbone, or the backbone with the Tn2 insertion in the same position. These plasmids have been found previously in Escherichia coli or Salmonella enterica recovered in several different countries from as early as the 1970s...
November 4, 2016: Plasmid
https://www.readbyqxmd.com/read/27821999/early-results-of-the-lps%C3%A2-limb-preservation-system-in-the-management-of-periprosthetic-femoral-fractures
#7
M Curtin, C Bryan, E Murphy, C G Murphy, W Curtin
INTRODUCTION: Achieving skeletal fixation in the presence of progressive bone loss is a surgical challenge, especially in cases of periprosthetic fracture (PPF). Unpredictable fracture patterns and preexisting bone loss frequently combine in this patient group. Megaprosthetic arthroplasty allows for immediate mobilisation and shorter periods of rehabilitation. We describe the clinical outcomes of a cohort of LPS™ megaprostheses performed for PPF by a single surgeon at our institution...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27813702/early-diagnosis-and-effective-treatment-regimens-are-the-keys-to-tackle-antimicrobial-resistance-in-tuberculosis-tb-a-report-from-euroscicon-s-international-tb-summit-2016
#8
Arundhati Maitra, Tengku Karmila Kamil, Monisha Shaik, Cynthia Amaning Danquah, Alina Chrzastek, Sanjib Bhakta
To say that tuberculosis (TB) has regained a strong foothold in the global human health and wellbeing scenario would be an understatement. Ranking alongside HIV/AIDS as the top reason for mortality due to a single infectious disease, the impact of TB extends far into socio-economic context worldwide. As global efforts led by experts and political bodies converge to mitigate the predicted outcome of growing antimicrobial resistance, the academic community of students, practitioners and researchers have mobilised to develop integrated, inter-disciplinary programmes to bring the plans of the former to fruition...
November 4, 2016: Virulence
https://www.readbyqxmd.com/read/27791240/feasibility-of-day-case-total-hip-arthroplasty-a-single-centre-observational-study
#9
Jens Rolighed Larsen, Birgitte Skovgaard, Thomas Prynø, Laimonas Bendikas, Lone R Mikkelsen, Malene Laursen, Mette T Høybye, Søren Mikkelsen, Lene Bastrup Jørgensen
INTRODUCTION: Recent reports indicate that total hip arthroplasty (THA) can be further accelerated and might be managed as day-case. This could provide benefits to health care expenditure, lower patient risks and change patient satisfaction. We evaluated the feasibility, efficacy, safety and patient satisfaction of same-day (<12 hours) THA operation and discharge. METHODS: Consecutive patients were screened for eligibility (primary THA, ASA 1 or 2 physical status) and the presence of a support person to follow the patient for 48 hours postoperatively in an observational study...
October 24, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27763657/renal-recruitment-of-b-lymphocytes-exacerbates-tubulointerstitial-fibrosis-by-promoting-monocyte-mobilisation-and-infiltration-after-unilateral-ureteral-obstruction
#10
Hui Han, Jinzhou Zhu, Yaqiong Wang, Zhengbin Zhu, Yanjia Chen, Lin Lu, Wei Jin, Xiaoxiang Yan, Ruiyan Zhang
Renal fibrosis is a significant threat to public health globally. Diverse primary aetiologies eventually result in chronic kidney disease (CKD) and immune cells influence this process. The roles of monocytes/macrophages, T cells and mast cells have been carefully examined, whilst only a few studies have focused on the effect of B cells. We investigated B cell function in tubulointerstitial fibrosis induced by unilateral ureteral obstruction (UUO), using genetic B cell-deficient μMT mice or CD20 antibody-mediated B cell depleted mice...
October 20, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27745753/the-sara-combilizer-%C3%A2-as-an-early-mobilisation-aid-for-critically-ill-patients-a-prospective-before-and-after-study
#11
David McWilliams, Gemma Atkins, James Hodson, Catherine Snelson
BACKGROUND: Early mobility within the ICU is associated with a number of positive outcomes including reductions in ICU and hospital length of stay and better functional recovery. The exact definition of 'early' mobility is still not defined, with the actual ability to mobilise limited by a number of perceived factors. The Sara Combilizer is a combined tilt table and stretcher chair, which allows passive transfer of patients out of bed. This study aimed to assess whether the introduction of the Sara Combilizer reduced time taken to first mobilise for patients mechanically ventilated for at least five days and at risk of ICU acquired weakness...
October 10, 2016: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/27724871/nitrogen-remobilisation-facilitates-adventitious-root-formation-on-reversible-dark-induced-carbohydrate-depletion-in-petunia-hybrida
#12
Siegfried Zerche, Klaus-Thomas Haensch, Uwe Druege, Mohammad-Reza Hajirezaei
BACKGROUND: Adventitious root (AR) formation in axillary shoot tip cuttings is a crucial physiological process for ornamental propagation that is utilised in global production chains for young plants. In this process, the nitrogen and carbohydrate metabolisms of a cutting are regulated by its total nitrogen content (Nt), dark exposure during transport and irradiance levels at distinct production sites and phases through a specific plasticity to readjust metabolite pools. Here, we examined how elevated Nt contents with a combined dark exposure of cuttings influence their internal N-pools including free amino acids and considered early anatomic events of AR formation as well as further root development in Petunia hybrida cuttings...
October 10, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27707496/early-goal-directed-mobilisation-in-the-surgical-intensive-care-unit-a-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Stefan J Schaller, Matthew Anstey, Manfred Blobner, Thomas Edrich, Stephanie D Grabitz, Ilse Gradwohl-Matis, Markus Heim, Timothy Houle, Tobias Kurth, Nicola Latronico, Jarone Lee, Matthew J Meyer, Thomas Peponis, Daniel Talmor, George C Velmahos, Karen Waak, J Matthias Walz, Ross Zafonte, Matthias Eikermann
BACKGROUND: Immobilisation predicts adverse outcomes in patients in the surgical intensive care unit (SICU). Attempts to mobilise critically ill patients early after surgery are frequently restricted, but we tested whether early mobilisation leads to improved mobility, decreased SICU length of stay, and increased functional independence of patients at hospital discharge. METHODS: We did a multicentre, international, parallel-group, assessor-blinded, randomised controlled trial in SICUs of five university hospitals in Austria (n=1), Germany (n=1), and the USA (n=3)...
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27707476/early-mobilisation-in-icu-is-far-more-than-just-exercise
#14
COMMENT
Theodore J Iwashyna, Carol L Hodgson
No abstract text is available yet for this article.
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27676977/active-mobility-early-after-stroke-a-randomised-controled-trial-amobes
#15
Alain Yelnik, Cedric Andriantsifanetra, Peggy Reinert, Mathilde Evrard, Hélène Marneff, Marie Wanepain, Margaux Barbie, Johann Beaudreuil, Jean Pascal Devailly, Eric Vicaut
OBJECTIVE: Active and intensive physical therapy (PT) facilitates motor recovery when provided at a subacute stage after stroke. The efficiency of very early intensive PT (within the 2 first weeks) has been much less investigated. Early intensive rehabilitation might be beneficial for neural plasticity but also detrimental by worsening the cerebral ischemia. The AVERT study (Bernhardt 2015) showed negative effect of high dose of very early mobilisation. MATERIAL/PATIENTS AND METHODS: Patients have been recruited in this multicentre randomized controlled trial (9 stroke units with PRM teams) to compare "soft" (20 min/day apart from respiratory needs) versus "intensive" PT (idem+45 minutes of intensive exercises/day), initiated within the 72 first hours after a first hemispheric stroke...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27634169/early-goal-directed-mobilisation-in-the-intensive-care-unit-is-feasible-and-safe-and-increases-both-the-level-and-duration-of-activity-synopsis
#16
Kylie Hill
No abstract text is available yet for this article.
October 2016: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27634164/early-goal-directed-mobilisation-in-the-intensive-care-unit-is-feasible-and-safe-and-increases-both-the-level-and-duration-of-activity-commentary
#17
Kelly Butler, William D Schweickert
No abstract text is available yet for this article.
October 2016: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27623094/clinical-trial-design-for-stem-cell-therapies-in-stroke-what-have-we-learned
#18
Keith W Muir
Stem cells of various sources have been investigated in a series of small, safety and feasibility-focused studies over the past 15 years. Understanding of mechanisms of action has evolved and the trial paradigms have become focused on two different approaches - one being an early subacute delivery of cells to reduce acute tissue injury and modify the tissue environment in a direction favourable to reparative processes (for example by being anti-inflammatory, anti-apoptotic, and encouraging endogenous stem cell mobilisation); the other exploring later delivery of cells during the recovery phase after stroke to modulate the local environment in favour of angiogenesis and neurogenesis...
September 10, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27622597/cell-wall-degradation-is-required-for-normal-starch-mobilisation-in-barley-endosperm
#19
Vasilios M E Andriotis, Martin Rejzek, Elaine Barclay, Michael D Rugen, Robert A Field, Alison M Smith
Starch degradation in barley endosperm provides carbon for early seedling growth, but the control of this process is poorly understood. We investigated whether endosperm cell wall degradation is an important determinant of the rate of starch degradation. We identified iminosugar inhibitors of enzymes that degrade the cell wall component arabinoxylan. The iminosugar 1,4-dideoxy-1, 4-imino-l-arabinitol (LAB) inhibits arabinoxylan arabinofuranohydrolase (AXAH) but does not inhibit the main starch-degrading enzymes α- and β-amylase and limit dextrinase...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27587519/the-technique-of-delivery-of-peri-operative-analgesia-does-not-affect-the-rehabilitation-or-outcomes-following-total-knee-arthroplasty
#20
D A McDonald, A H Deakin, B M Ellis, Y Robb, T E Howe, A W G Kinninmonth, N B Scott
AIMS: This non-blinded randomised controlled trial compared the effect of patient-controlled epidural analgesia (PCEA) versus local infiltration analgesia (LIA) within an established enhanced recovery programme on the attainment of discharge criteria and recovery one year after total knee arthroplasty (TKA). The hypothesis was that LIA would increase the proportion of patients discharged from rehabilitation by the fourth post-operative day but would not affect outcomes at one year. PATIENTS AND METHODS: A total of 242 patients were randomised; 20 were excluded due to failure of spinal anaesthesia leaving 109 patients in the PCEA group and 113 in the LIA group...
September 2016: Bone & Joint Journal
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