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https://www.readbyqxmd.com/read/28801130/prospective-implementation-of-enhanced-recovery-after-surgery-protocols-to-radical-cystectomy
#1
Karl H Pang, Ruth Groves, Suresh Venugopal, Aidan P Noon, James W F Catto
BACKGROUND: Multimodal enhanced recovery after surgery (ERAS) regimens have improved outcomes from colorectal surgery. OBJECTIVE: We report the application of ERAS to patients undergoing radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS: Prospective collection of outcomes from consecutive patients undergoing RC at a single institution. INTERVENTION: Twenty-six components including prehabilitation exercise, same day admission, carbohydrate fluid loading, targeted intraoperative fluid resuscitation, regional local anaesthesia, cessation of nasogastric tubes, omitting oral bowel preparation, avoiding drain use, early mobilisation, chewing gum use, and audit...
August 8, 2017: European Urology
https://www.readbyqxmd.com/read/28768427/enhanced-recovery-programmes-for-lower-limb-arthroplasty-in-the-uk
#2
N S Nagra, T W Hamilton, L Strickland, D W Murray, H Pandit
Introduction Enhanced recovery programmes (ERPs) reduce patient morbidity and mortality, and provide significant cost savings by reducing length of stay. Currently, no uniform ERP guidelines exist for lower limb arthroplasty in the UK. The aim of this study was to identify variations in ERPs and determine adherence to local policy. Methods Hospitals offering elective total knee arthroplasty (TKA) and total hip arthroplasty (THA) (23 and 22 centres respectively) contributed details of their ERPs, and performed an audit (15 patients per centre) to assess compliance...
August 3, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28750286/short-term-forecasting-of-turbidity-in-trunk-main-networks
#3
Gregory Meyers, Zoran Kapelan, Edward Keedwell
Water discolouration is an increasingly important and expensive issue due to rising customer expectations, tighter regulatory demands and ageing Water Distribution Systems (WDSs) in the UK and abroad. This paper presents a new turbidity forecasting methodology capable of aiding operational staff and enabling proactive management strategies. The turbidity forecasting methodology developed here is completely data-driven and does not require hydraulic or water quality network model that is expensive to build and maintain...
July 17, 2017: Water Research
https://www.readbyqxmd.com/read/28743548/identifying-barriers-to-early-mobilisation-among-mechanically-ventilated-patients-in-a-trauma-intensive-care-unit
#4
Kari Johnson, Jamie Petti, Amy Olson, Tina Custer
Mechanically ventilated patients can be at risk for functional decline (Cameron et al., 2015). Early mobilisation of mechanically ventilated patients can improve outcomes after critical illness to prevent this decline. Although registered nurses understand the importance of early mobilisation there are nurses who are unwilling to mobilise patients. AIM: The aim of this study is to examine whether nurses' attitudes and beliefs are barriers for early mobilisation and evaluate whether an education intervention can improve early mobilisation...
July 22, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28741202/a-user-centred-approach-to-developing-bwell-a-mobile-app-for-arm-and-shoulder-exercises-after-breast-cancer-treatment
#5
Helena Harder, Patrick Holroyd, Lynn Burkinshaw, Phil Watten, Charles Zammit, Peter R Harris, Anna Good, Val Jenkins
PURPOSE: The study aim was to develop a mobile application (app) supported by user preferences to optimise self-management of arm and shoulder exercises for upper-limb dysfunction (ULD) after breast cancer treatment. METHODS: Focus groups with breast cancer patients were held to identify user needs and requirements. Behaviour change techniques were explored by researchers and discussed during the focus groups. Concepts for content were identified by thematic analysis...
July 24, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28724755/trim33-tif1-%C3%AE-is-essential-for-macrophage-and-neutrophil-mobilisation-to-developmental-or-inflammatory-cues
#6
Doris Lou Demy, Muriel Tauzin, Mylène Lancino, Véronique le Cabec, Michael Redd, Emi Murayama, Isabelle Maridonneau-Parini, Nikolaus Trede, Philippe Herbomel
Macrophages infiltrate and establish in developing organs from an early stage, often before these have become vascularised. Similarly, leukocytes in general can quickly migrate through tissues to any site of wounding. This unique capacity is rooted in their characteristic amoeboid motility, the genetic basis of which is poorly known. Trim33 (Tif1-γ), a nuclear protein that associates with specific DNA binding transcription factors to modulate gene expression, has been found mainly involved in hematopoiesis and gene regulation by TGF-ß...
July 19, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28716351/effect-of-provision-of-home-based-curative-health-services-by-public-sector-health-care-providers-on-neonatal-survival-a-community-based-cluster-randomised-trial-in-rural-pakistan
#7
Sajid Soofi, Simon Cousens, Ali Turab, Yaqub Wasan, Shah Mohammed, Shabina Ariff, Zaid Bhatti, Imran Ahmed, Steve Wall, Zulfiqar A Bhutta
BACKGROUND: Although the effectiveness of community mobilisation and promotive care delivered by community health workers in reducing perinatal and neonatal mortality is well established, evidence in support of home-based neonatal resuscitation and infection management is mixed. We assessed the effectiveness of adding training in neonatal bag and mask resuscitation and oral antibiotic therapy for suspected neonatal infections to a basic preventive and promotive interventions package delivered by public sector community-based lady health workers (LHWs) in rural Pakistan...
August 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28704008/-can-mobilization-preserve-the-elderly-hospitalized-from-functional-decline
#8
Marie Méan, Christophe Bula, Gérard Waeber
Up to 65% of older adults who walk independently will lose this capacity during a hospital stay. In older adults, loss of walking independence increases the length of hospital stay, the need for rehabilitation services and for institutionalization, as well as the risk of falls (during hospital stay and after discharge) and the risk of death. Bed rest or limited walking during a hospital stay causes deconditioning and is one of the primary risk factors for loss of independence and adverse outcome in hospitalized older adults...
January 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28699541/randomised-controlled-trials-and-changing-public-health-practice
#9
EDITORIAL
Anne Cockcroft
One reason for doing randomised controlled trials (RCTs) is that experiments can be convincing. Early epidemiological experimenters, such as Jenner and the smallpox vaccine and Snow and his famous Broad Street pump handle, already knew the answer they were demonstrating; they used the experiments as knowledge translation devices to convince others.More sophisticated modern experiments include cluster randomised controlled trials (CRCTs) for experiments in the public health setting. The knowledge translation value remains: RCTs and CRCTs can potentially stimulate changes of practice among stakeholders...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28690031/prevalence-of-pain-in-240-non-ambulatory-children-with-severe-cerebral-palsy
#10
I Poirot, V Laudy, M Rabilloud, S Roche, T Ginhoux, B Kassaï, C Vuillerot
BACKGROUND: Several studies have given frequencies of pain in children with cerebral palsy, but comparing the findings is difficult. We aimed to estimate the prevalence of pain in non-ambulatory children with cerebral palsy and describe their characteristics by presence or absence of pain. METHODS: Data were extracted from an ongoing longitudinal national cohort following non-ambulatory children with severe cerebral palsy aged 3 to 10years over 10years. We described and compared data for the first 240 children at inclusion by presence or absence of pain...
July 6, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28669018/revision-knee-arthroplasty-using-a-distal-femoral-replacement-prosthesis-for-periprosthetic-fractures-in-elderly-patients
#11
Ehab Girgis, Christoph McAllen, Jonathan Keenan
PURPOSE: Distal femoral periprosthetic fractures above a total knee replacement in elderly patients are technically challenging to treat. Bone quality is often poor, the fractures comminuted, and post-operative mobilisation is difficult. This study assesses the clinical, radiological and functional outcome of revision knee distal femoral replacement (DFR) in these fractures. METHODS: We identified 14 patients over 70 years of age (70-94) who underwent DFR for periprosthetic fractures above a knee replacement...
July 1, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28654699/early-mobilisation-after-total-hip-or-knee-arthroplasty-a-multicentre-prospective-observational-study
#12
Matthew J Chua, Andrew J Hart, Rajat Mittal, Ian A Harris, Wei Xuan, Justine M Naylor
OBJECTIVE: Early mobilisation is recommended following total hip arthroplasty (THA) or total knee arthroplasty (TKA) to prevent venous thromboembolism (VTE). We sought to determine the proportions of patients that first mobilised on post-operative day 0 (POD 0) and factors associated with earlier time to mobilisation. METHODS: A prospective cohort study was conducted involving patients with hip or knee osteoarthritis who had undergone primary unilateral THA (n = 818) and TKA (n = 989) at 19 Australian hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/28630761/partial-proximal-tibia-fractures
#13
Michael J Raschke, Christoph Kittl, Christoph Domnick
Partial tibial plateau fractures may occur as a consequence of either valgus or varus trauma combined with a rotational and axial compression component.High-energy trauma may result in a more complex and multi-fragmented fracture pattern, which occurs predominantly in young people. Conversely, a low-energy mechanism may lead to a pure depression fracture in the older population with weaker bone density.Pre-operative classification of these fractures, by Müller AO, Schatzker or novel CT-based methods, helps to understand the fracture pattern and choose the surgical approach and treatment strategy in accordance with estimated bone mineral density and the individual history of each patient...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28588990/cognitive-capital-equity-and-child-sensitive-social-protection-in-asia-and-the-pacific
#14
Michael Samson, Gaspar Fajth, Daphne François
Promoting child development and welfare delivers human rights and builds sustainable economies through investment in 'cognitive capital'. This analysis looks at conditions that support optimal brain development in childhood and highlights how social protection promotes these conditions and strengthens the achievement of the Sustainable Development Goals (SDGs) in Asia and the Pacific. Embracing child-sensitive social protection offers multiple benefits. The region has been a leader in global poverty reduction but the underlying pattern of economic growth exacerbates inequality and is increasingly unsustainable...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28580845/-nobody-teases-good-girls-a-qualitative-study-on-perceptions-of-sexual-harassment-among-young-men-in-a-slum-of-mumbai
#15
Susannah Zietz, Madhumita Das
Young adulthood is a key period in which gender norms are solidified. As a result, young women are particularly vulnerable to gender-based violence. In Delhi, over 90% of women have ever experienced sexual violence in public spaces. Sexual harassment of girls and women in public spaces is commonly named 'eve teasing' in India. Experience of sexual harassment in public spaces has been found to be associated with restricted mobility, interrupted education, and early age at marriage. Little is known about men's perspectives on eve teasing and how they believe it affects women and girls...
June 5, 2017: Global Public Health
https://www.readbyqxmd.com/read/28580817/changes-in-low-molecular-weight-thiol-disulphide-redox-couples-are-part-of-bread-wheat-seed-germination-and-early-seedling-growth
#16
Davide Gerna, Thomas Roach, Wolfgang Stöggl, Johanna Wagner, Patrizia Vaccino, Margherita Limonta, Ilse Kranner
The tripeptide antioxidant glutathione (γ-l-glutamyl-l-cysteinyl-glycine; GSH) essentially contributes to thiol-disulphide conversions, which are involved in the control of seed development, germination, and seedling establishment. However, the relative contribution of GSH metabolism in different seed structures is not fully understood. We studied the GSH/glutathione disulphide (GSSG) redox couple and associated low-molecular-weight (LMW) thiols and disulphides related to GSH metabolism in bread wheat (Triticum aestivum L...
June 26, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28575074/lessons-learnt-from-human-papillomavirus-hpv-vaccination-in-45-low-and-middle-income-countries
#17
Katherine E Gallagher, Natasha Howard, Severin Kabakama, Sandra Mounier-Jack, Ulla K Griffiths, Marta Feletto, Helen E D Burchett, D Scott LaMontagne, Deborah Watson-Jones
OBJECTIVE: To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects and national programmes in low- and middle-income countries (LAMICs). METHODS: Interviews were conducted with 56 key informants. A systematic literature review identified 2936 abstracts from five databases; after screening 61 full texts were included. Unpublished literature, including evaluation reports, was solicited from country representatives; 188 documents were received...
2017: PloS One
https://www.readbyqxmd.com/read/28549273/body-weight-supported-bedside-treadmill-training-facilitates-ambulation-in-icu-patients-an-interventional-proof-of-concept-study
#18
Juultje Sommers, Denise C Wieferink, Dave A Dongelmans, Frans Nollet, Raoul H H Engelbert, Marike van der Schaaf
PURPOSE: Early mobilisation is advocated to improve recovery of intensive care unit (ICU) survivors. However, severe weakness in combination with tubes, lines and machinery are practical barriers for the implementation of ambulation with critically ill patients. The aim of this study was to explore the feasibility of Body Weight-Supported Treadmill Training (BWSTT) in critically ill patients in the ICU. METHODS: A custom build bedside Body Weight-Supported Treadmill was used and evaluated in medical and surgical patients in the ICU...
May 13, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28540806/laparoscopic-hyperthermic-isolated-limb-perfusion-a-new-minimally-invasive-approach-for-hilp
#19
N Solari, F Sucameli, M Gipponi, F De Cian, F Cafiero
BACKGROUND: Hyperthermic isolated limb perfusion (HILP) represents a limb-sparing treatment for unresectable soft tissue sarcoma (STS) of the extremities with substantial complete response rates. HILP often provides good functional limb preservation, hence a significant improvement also in terms of quality of life of the patient. Notwithstanding these clear advantages, the traditional technique is still hindered by relatively high post-operative morbidity. METHOD: We treated a 78-year-old female with unresectable angiosarcoma of the left leg using a new surgical approach: an entirely laparoscopic HILP...
April 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28537541/-earlier-weight-bearing-mobilisation-after-fracture-fixation
#20
P R G Brink, E J M M Verleisdonk, T J Blokhuis
Almost all the literature dictates a period of non-weight-bearing after surgical treatment of articular and peri-articular fractures of the pelvis and lower extremities. This is followed by partial weight-bearing which is based on the number of weeks after surgery. However, none of these recommendations are based on evidence. When taking muscle force and gravity into account, non-weight-bearing is actually impossible. In addition, lack of patient compliance, lack of muscle force in the elderly and four-fold energy expenditure make it almost impossible to ensure that patients will adhere to their surgeon's restrictions...
2017: Nederlands Tijdschrift Voor Geneeskunde
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