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https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#1
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29146094/is-balloon-kyphoplasty-a-better-treatment-than-percutaneous-vertebroplasty-for-chronic-obstructive-pulmonary-disease-copd-patients-with-osteoporotic-vertebral-compression-fractures-ovcfs
#2
Xinjie Wu, Xiangsheng Tang, Mingsheng Tan, Ping Yi, Feng Yang
BACKGROUND: Although several studies reported that Balloon kyphoplasty (BK) or percutaneous vertebroplasty (PVP) could improve pulmonary functions, there is no study to compare the efficacy and safety of 2 procedures in COPD patients with osteoporotic vertebral compression fractures (OVCFs) and investigate the reason why they could improve pulmonary functions. METHOD: Two procedures, including BK and PVP were performed in 61 COPD patients with single-level OVCFS...
November 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29116357/injectable-biomechanically-robust-biodegradable-and-osseointegrative-bone-cement-for-percutaneous-kyphoplasty-and-vertebroplasty
#3
Huiling Liu, Bin Liu, Chunxia Gao, Bin Meng, Huilin Yang, Haiyang Yu, Lei Yang
PURPOSE: Poly(methyl methacrylate) (PMMA) cement is widely used for percutaneous kyphoplasty and vertebroplasty (PKP and PVP) but possesses formidable shortcomings due to non-degradability. Here, a biodegradable replacement is developed. METHODS: Calcium phosphate cement (CPC) was redesigned by incorporating starch and BaSO4 (new cement named as CPB). The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo by the models of osteoporotic sheep vertebra, rat subcutaneous implantation and rat femoral defect...
November 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29114290/open-c2-vertebroplasty-case-report-technique-and-review-of-literature
#4
Sathwik Raviraj Shetty, Praveen Mahadev Ganigi, Bopanna Kanjithanda Mandanna
Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invasive technique has been widely used in lytic lesions of thoracic and lumbar spine. However, there has been limited experience with percutaneous vertebroplasty at C2, and the procedure is technically difficult. We describe a safer alternative technique of open vertebroplasty for lytic lesions involving the axis. METHODS: The procedure was performed in a 49-year-old male with a metastatic lytic lesion involving the body and dens of C2 using an anterior cervical approach...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29103064/risk-factors-associated-with-adjacent-vertebral-compression-fracture-following-percutaneous-vertebroplasty-after-menopause-a-retrospective-study
#5
Hua Li, Da-Long Yang, Lei Ma, Hui Wang, Wen-Yuan Ding, Si-Dong Yang
BACKGROUND Clinically, percutaneous vertebroplasty (PVP) is frequently applied to treat osteoporotic vertebral compression fracture (OVCF). It is believed that new compression fractures are more likely to occur adjacent to the PVP-treated segment, typically within 1 month after PVP. The purpose of this study was to investigate risk factors for adjacent vertebral compression fractures (AVCF) after PVP in patients with OVCF after menopause. MATERIAL AND METHODS Between Jun 2012 and Dec 2016, 412 patients were initially identified...
November 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29100666/use-of-corticosteroids-is-not-associated-with-repeated-vertebroplasty-or-kyphoplasty-within-one-year-after-the-surgery-in-patient-older-than-50-years
#6
Feng-Chen Kao, Yao-Chun Hsu, Chin-Hsien Wu, Chang-Bi Wang, Yuan-Kun Tu, Pao-Hsin Liu
OBJECTIVE: The aim of this study was to investigate whether corticosteroid use increases the incidence of repeated PVP or kyphoplasty patients older than 50 years. METHODS: This study enrolled the data of 2,753 eligible patients from the Taiwan National Health Insurance Research Database who were exposed to systemic corticosteroids for at least 3 months during the first year preceding the first PVP or kyphoplasty. These steroid users were matched 1:1 in age, sex, and the index date of surgery with non-user controls during the enrollment period...
October 31, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29099164/synthesis-and-characterization-of-an-injectable-and-hydrophilous-expandable-bone-cement-based-on-poly-methyl-methacrylate
#7
Zhao Yang, Lei Chen, Yuxin Hao, Yuan Zang, Xiong Zhao, Lei Shi, Yang Zhang, Yafei Feng, Chao Xu, Faqi Wang, Xinli Wang, Bowen Wang, Chenxin Liu, Yufei Tang, Zixiang Wu, Wei Lei
Poly(methyl methacrylate) (PMMA), the most common bone cement, has been used as a graft substitute in orthopedic surgeries such as vertebroplasty. However, an undesirable minor crack in the bone-cement interface provoked by shrinkage during polymerization and high elastic modulus of conventional PMMA bone cement dramatically increases the risk of vertebral body refracture postsurgery. Thus, herein, a hydrophilous expandable bone cement was synthesized based on a PMMA commercial cement (Mendec Spine Resin), acrylic acid (AA), and styrene (St)...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29096745/application-of-unilateral-multiple-channels-approach-in-percutaneous-vertebroplasty-for-osteoporotic-vertebral-fractures
#8
H Wei, X Ma
This study aimed to investigate the application valuable of percutaneous vertebroplasty (PVP) with unilateral multiple channels approach in osteoporotic vertebral fractures patients. A retrospective review was conducted on 685 consecutive patients with osteoporotic vertebral fracture from March 2003 to October 2012. Among them, 82 cases were given PVP procedure by unilateral multiple channels approach. The timing of surgery, bone cements injection, and complications were analyzed. By using the X-ray film, the distribution of cement was detected and scored...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29093786/perioperative-medical-complications-after-posterior-approach-spinal-instrumentation-surgery-for-osteoporotic-vertebral-collapse-a-comparative-study-in-patients-with-primary-osteoporosis-and-those-with-secondary-osteoporosis
#9
Naohisa Miyakoshi, Takashi Kobayashi, Tetsuya Suzuki, Kazuma Kikuchi, Yuji Kasukawa, Yoichi Shimada
Study Design: A retrospective comparative study. Purpose: To compare perioperative medical complications after posterior approach spinal instrumentation surgery for osteoporotic vertebral collapse (OVC) between patients with primary osteoporosis and those with secondary osteoporosis. Overview of Literature: With increased aging of society, the demand for instrumentation surgery for an osteoporotic spine has been increasing. However, no studies have compared the rates or severities of perioperative complications after spinal instrumentation surgery between patients with primary osteoporosis and those with secondary osteoporosis...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29087367/which-combination-treatment-is-better-for-spinal-metastasis-percutaneous-vertebroplasty-with-radiofrequency-ablation-125i-seed-zoledronic-acid-or-radiotherapy
#10
Chun-Wen Lu, Jie Shao, Yu-Gang Wu, Chao Wang, Jin-Hui Wu, Run-Xiao Lv, Mu-Chen Ding, Zhi-Cai Shi, Ning-Fang Mao
BACKGROUND: Percutaneous vertebroplasty (PVP) can not only alleviate pain but also restore mechanical stability with injection of bone cement, whereas it exhibits a poor effect on antitumor activity. But through combinations with other therapies, it may be possible to achieve the maximum effect in clinical treatment. Thus, this study is designed to assess the clinical efficacy of PVP separately combined with 4 ways for spinal metastasis (SM) treatment. STUDY QUESTION: Which combination treatment is better for spinal metastasis, percutaneous vertebroplasty with radiofrequency ablation, I seed, zoledronic acid or radiotherapy? STUDY DESIGN: A total of 169 patients with SM were retrospectively recruited and randomly assigned to 4 groups to receive 4 different ways separately: 49 patients (group A) received PVP plus I seed, 51 (group B) received PVP plus radiofrequency ablation (RFA), 38 (group C) underwent PVP plus zoledronic acid (ZA), and 31 (group D) underwent PVP plus radiotherapy (RT)...
April 26, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29086094/influence-of-blood-supply-on-fracture-healing-of-vertebral-bodies
#11
L Hajnovic, V Sefranek, L Schütz
INTRODUCTION: The relevance of blood supply for bone fracture healing has been discussed throughout the literature, using scaphoids as the most referred to. But, there is virtually nothing known about the relevance of blood supply for the vertebral fracture healing and even the guidelines of AO do not deal with this issue. MATERIALS AND METHODS: A prospective cohort study of 107 patients was run from January 2016 to December 2016, with 54 male and 53 female patients, who were treated for traumatic vertebral fractures of thoracolumbar spine using posterior stabilization only...
October 30, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29069831/stereotactic-ablative-body-radiotherapy-for-spinal-metastasis-from-hepatocellular-carcinoma-its-oncologic-outcomes-and-risk-of-vertebral-compression-fracture
#12
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Won Kyung Cho, Eonju Lee, Sang Hoon Jung, Youngyih Han, Eun-Sang Kim, Sun-Ho Lee, Whan Eoh, Se-Jun Park, Sung-Soo Chung, Chong-Suh Lee, Joon Hyuk Lee
Spinal metastases from hepatocellular carcinoma (HCC) require high-dose irradiation for durable pain and tumor control. Stereotactic ablative body radiotherapy (SABR) enables the delivery of high-dose radiation. However, but vertebral compression fracture (VCF) can be problematic. The aim of his study is to evaluate the outcome and risk of VCF after SABR for spinal metastasis from HCC. We retrospectively reviewed 33 lesions in 42 spinal segments from 29 patients who received SABR with 1 fraction (16-20 Gy), or 3 fractions (18-45 Gy) from September 2009 to January 2015...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29063215/were-vcf-patients-at-higher-risk-of-mortality-following-the-2009-publication-of-the-vertebroplasty-sham-trials
#13
K L Ong, D P Beall, M Frohbergh, E Lau, J A Hirsch
The 5-year period following 2009 saw a steep reduction in vertebral augmentation volume and was associated with elevated mortality risk in vertebral compression fracture (VCF) patients. The risk of mortality following a VCF diagnosis was 85.1% at 10 years and was found to be lower for balloon kyphoplasty (BKP) and vertebroplasty (VP) patients. INTRODUCTION: BKP and VP are associated with lower mortality risks than non-surgical management (NSM) of VCF. VP versus sham trials published in 2009 sparked controversy over its effectiveness, leading to diminished referral volumes...
October 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29057344/utilization-of-vertebroplasty-and-kyphoplasty-procedures-throughout-the-united-states-over-a-recent-decade-an-analysis-of-the-nationwide-inpatient-sample
#14
Joseph L Laratta, Jamal N Shillingford, Joseph M Lombardi, John D Mueller, Hemant Reddy, Comron Saifi, Charla R Fischer, Steven C Ludwig, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Given the increasing societal focus on health care utilization and value-based care, it is essential to understand the demographic and economic data surrounding percutaneous vertebral augmentation procedures performed in the United States. Double-blinded prospective randomized controlled trials have shown no benefit to the use of vertebroplasty over a sham procedure in the treatment of vertebral fractures. Contrastingly, kyphoplasty may be beneficial when appropriately indicated...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29054227/life-threatening-cardiac-perforation-after-posterior-spondylodesis
#15
Michaela Andrä, Harald Baumer, Florian Mittergradnegger, Michael Laschitz, Tadej Petek, Wolfgang Wandschneider
This reports presents a case of a 62-year-old woman with hemorrhagic hypovolemic shock, respiratory distress, and pericardial effusion secondary to right atrial perforation caused by a cement embolus after dorsal spondylodesis. Despite optimal intensive care support for a supposed pulmonary embolism, the patient's condition markedly deteriorated. On delayed embolus recognition by contrast-enhanced computed tomography and transesophageal echocardiography, she had to undergo cardiac surgery. Cardiac involvement is a rare but important complication, with few cases described after vertebroplasty and none after spondylodesis...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29031993/the-gdf5-mutant-bb-1-enhances-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#16
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (BMPs; e.g., GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose BB-1 in a sheep lumbar osteopenia model...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29021684/use-of-c2-vertebroplasty-and-stereotactic-radiosurgery-for-treatment-of-lytic-metastasis-of-the-odontoid-process
#17
Casey Alicen Hribar, Deb A Bhowmick
Improvements in cancer therapy have led to increased patient survival times in spite of metastatic spinal disease in many forms of cancer. Conventional treatment methods often employ radiotherapy with or without surgery depending on the neurological status, mechanical instability, and the extent of tumor. Percutaneous vertebroplasty as well as stereotactic radiosurgery (SRS) have arisen as common modalities of treatment of spinal metastasis in which neurological compromise or spinal instability and deformity is not of significant concern...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28988630/differences-in-short-term-clinical-and-radiological-outcomes-depending-on-timing-of-balloon-kyphoplasty-for-painful-osteoporotic-vertebral-fracture
#18
Shinji Takahashi, Masatoshi Hoshino, Hidetomi Terai, Hiromitsu Toyoda, Akinobu Suzuki, Koji Tamai, Kyoei Watanabe, Tadao Tsujio, Hiroyuki Yasuda, Hiroshi Kono, Ryuichi Sasaoka, Sho Dohzono, Kazunori Hayashi, Shoichiro Ohyama, Yusuke Hori, Hiroaki Nakamura
BACKGROUND: Balloon kyphoplasty or vertebroplasty is widely performed as a surgical intervention for osteoporotic vertebral fracture (OVF) and the effects have been investigated in many previous studies. However, the influence of the timing of the procedure on patient outcomes has not been studied formally. The purpose of this study was to investigate differences in the surgical outcomes of OVFs according to the timing of balloon kyphoplasty. METHODS: This was a multicenter cohort study...
October 4, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28979679/dynamic-characteristics-of-osteoporotic-lumbar-spine-under-vertical-vibration-after-cement-augmentation
#19
Xinlin Su, Hao Shen, Weidong Shi, Huilin Yang, Feng Lv, Jun Lin
Being beneficial in restoring stability and stiffness of osteoporotic vertebraes, cement augmentation techniques including vertebroplasty (VP) and kyphoplasty (KP) have been demonstrated to be effective for the treatment of patients with osteoporotic vertebral compressive fractures (OVCFs). However, it is unclear the influence of cement augmentation on the dynamics of pathologic and adjacent vertebraes under vibration condition. In this study, we developed a three-dimensional (3D) finite-element (FE) model of the spinal T12-Pelvis segment by using CT scan data of lumbar spine of an adult woman with no physical abnormalities...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28969223/evaluation-of-percutaneous-vertebroplasty-for-management-of-symptomatic-osteoporotic-compression-fracture
#20
Arnab Karmakar, Suchi Acharya, Dibyendu Biswas, Arkaprabha Sau
INTRODUCTION: Osteoporotic vertebral compression fractures are a leading cause of disability and associated morbidities among Indian population. Worldwide, approximately 20% of elderly population above 70 years and 16% of postmenopausal women are suffering from it. Vertebral compression fractures should be aggressively treated with minimally invasive techniques such as Percutaneous Vertebroplasty (PVP) or Percutaneous Kyphoplasty (PKP) to minimize pain and disability associated with it...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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