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Anticoagulation and metabolic syndrome

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https://www.readbyqxmd.com/read/28714498/chondrodysplasia-punctata-a-case-report-of-fetal-warfarin-syndrome
#1
S Songmen, O B Panta, S S Paudel, R K Ghimire
Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism. Warfarin, an oral anticoagulant acting on vitamin K dependent clotting factors is known to cause chondrodysplasia punctata. Despite the knowledge of the condition the management of patients with prosthetic heart valves might require use of the drug for anticoagulation. Here, we present a case of a fetal warfarin syndrome in a second born child of a 27 year lady under warfarin for prosthetic heart valve...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28651914/phenylsulfonylfuroxan-no-donor-phenols-synthesis-and-multifunctional-activities-evaluation
#2
Yundong Xie, Yaping Yang, Sen Li, Yanhong Xu, Wenfang Lu, Zizhang Chen, Guangde Yang, Yiping Li, Yongxiao Cao, Xiaoli Bian
Phenylsulfonyfuroxan nitric oxide (NO)-donor phenols were designed, synthesized and evaluated. The compounds were designed through a symbiotic approach using selected phenols and phenylsulfonylfuroxan NO-donor. The antioxidant activities of the hybrid compounds T2-T6 showed to be good in vivo. Compounds T4 and T6 revealed excellent yeast α-glucosidase inhibitory activity and anti-glycosylation activity. All of the compounds exhibited strong NO releasing activity and significant anti-platelet aggregation activity...
August 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28574383/-cardioreabilitation-peculiarities%C3%A2-and-correction-of-violations-of-sistolic-diasolic-function-and-heart-rate-variability-in-patients-with-acute-coronary-syndrome-and-coronary-artery-revascularization
#3
M Shved, L Tsuglevych, I Kyrychok, L Levytska, T Boiko, Ya Kitsak
In patients with acute coronary syndrome (ACS) who underwent coronary arteries revascularization, violations of hemodynamics, metabolism and heart rate variability often develop in the postoperative period, therefore, the goal of the study was to establish the features of disturbances and the effectiveness of correction of left ventricular systolic and diastolic dysfunction and heart rate variability in stages of cardiorehabilitation in patients with acute coronary syndrome who underwent coronary arteries revascularization...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28553146/recurrent-pregnancy-loss-current-perspectives
#4
REVIEW
Hady El Hachem, Vincent Crepaux, Pascale May-Panloup, Philippe Descamps, Guillaume Legendre, Pierre-Emmanuel Bouet
Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28263045/interrelationship-between-venous-and-arterial-thrombosis
#5
Pavel Poredos
In the past, arterial and venous thrombosis have been accepted as two completely different diseases. Recently, the thesis of two separate pathogenetic mechanisms of venous and arterial thrombosis has been challenged by accumulation of evidence which suggest that patients with atherothrombosis are at increased risk for venous thrombosis. Pathophysiological studies indicated that etiopathogenetic mechanisms of both diseases are similar and that coagulation and platelet activation participate in both venous and arterial thrombogenesis...
March 6, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28222379/increased-static-and-decreased-capacity-oxidation-reduction-potentials-in-plasma-are-predictive-of-metabolic-syndrome
#6
Gerd Bobe, Tora J Cobb, Scott W Leonard, Savinda Aponso, Christopher B Bahro, Dipankar Koley, Eunice Mah, Richard S Bruno, Maret G Traber
Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28100362/-severe-obstructive-sleep-apnea-hypopnea-syndrome-with-dilated-cardiomyopathy-leading-to-pulmonary-hypertension-case-report-and-literature-review
#7
R K Chen, C Hong, Y M Zhou, A L Kuang, Y T Zhang, S M Qing, C L Liu, N F Zhang
Objective: To study the relationship between dilated cardiomyopathy and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate the curative effects of continuous positive airway pressure (CPAP) in OSAHS complicated with dilated cardiomyopathy. Methods: We reported one case with the symptom of exertional dyspnea for 1 year and aggravating for 1 month. The patient finally was diagnosed with severe OSAHS complicated with dilated cardiomyopathy leading to pulmonary hypertension. A systematic literature review was performed for similar published cases in Pubmed, Wanfang and CNKI database, using the keywords (obstructive sleep apnea) OR(OSA) OR(OSAHS) AND(dilated cardiomyopathy OR DCM)from January 1990 to May 2016...
January 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27748329/effect-of-metabolic-syndrome-on-risk-stratification-for-left-atrial-or-left-atrial-appendage-thrombus-formation-in-patients-with-nonvalvular-atrial-fibrillation
#8
Yu-Yang Chen, Qi Liu, Li Liu, Xiao-Rong Shu, Zi-Zhuo Su, Hai-Feng Zhang, Ru-Qiong Nie, Jing-Feng Wang, Shuang-Lun Xie
BACKGROUND: Metabolic syndrome (MS) is a risk factor for stroke and thromboembolism event. Left atrial or LA appendage (LA/LAA) thrombus is a surrogate of potential stroke. The relationship between MS and atrial thrombus remains unclear. In this study, we sought to investigate the effect of MS on risk stratification of LA/LAA thrombus formation in patients with nonvalvular atrial fibrillation (NVAF). METHODS: This cross-sectional study enrolled 294 consecutive NVAF patients without prior anticoagulant and lipid-lowering therapies...
October 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27319232/-clinical-implications-of-polycystic-ovary-syndrome
#9
Ingrid Dravecká
UNLABELLED: Polycystic ovary syndrome (PCOS) is a heterogeneous and complex endocrine disease which among the female population belongs to the most widespread endocrinopathies and it is the most frequent cause of hyperthyroidism, anticoagulation and infertility. Insulin resistance is one of the important diabetology factors impacting hyperglycaemia in a majority of women with PCOS (60-80 %). Clinical expressions of PCOS include reproduction disorders, metabolic characteristics and psychological implications...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26927210/intra-uterine-growth-retardation-as-a-risk-factor-of-postnatal-metabolic-disorders
#10
REVIEW
Radzislaw Mierzynski, Dominik Dluski, Dorota Darmochwal-Kolarz, Elzbieta Poniedziałek-Czajkowska, Bozena Leszczynska-Gorzelak, Zaneta Kimber-Trojnar, Agnieszka-Wankowicz, Jan Oleszczuk
Intra-uterine growth retardation (IUGR) represents one of the major problems in perinatal medicine. IUGR is one of main causes of perinatal mortality and morbidity. A huge number and variety of established and possible causes of IUGR have been described. There are currently no data about effective treatment of this fetal condition. IUGR has been described to be strictly involved in fetal programming. Fetal programming is the general idea, which tells us how during development of the embryo and fetus significant physiological parameters can be shaped by environmental events...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/26857880/adverse-drug-reactions-in-elderly-patients-with-cognitive-disorders-a-systematic-review
#11
REVIEW
Lukshe Kanagaratnam, Moustapha Dramé, Thierry Trenque, Nadia Oubaya, Pierre Nazeyrollas, Jean-Luc Novella, Damien Jolly, Rachid Mahmoudi
Elderly subjects with cognitive disorders are at particularly high risk of adverse drug reactions (ADRs). The objectives of our systematic review were to describe the prevalence of ADRs in elderly patients with cognitive disorders, the different types of ADRs and the medications suspected of involvement; to describe whether the ADRs were preventable or not, and to identify risk factors for occurrence of ADRs in this population. A bibliographic search was performed in the following databases: PubMed, Embase, Google Scholar, Opengrey and Scopus...
March 2016: Maturitas
https://www.readbyqxmd.com/read/26471883/cardiovascular-risk-stratification-in-patients-with-non-valvular-atrial-fibrillation-the-2mace-score
#12
Daniele Pastori, Alessio Farcomeni, Daniela Poli, Emilia Antonucci, Francesco Angelico, Maria Del Ben, Roberto Cangemi, Gaetano Tanzilli, Gregory Yoke Hong Lip, Pasquale Pignatelli, Francesco Violi
Recent findings suggest that patients with non-valvular atrial fibrillation (AF), in addition to having a high risk for ischemic stroke, are also at risk for myocardial infarction (MI). The aim of the study was to combine factors predicting Major Adverse Cardiovascular Events (MACE) in AF patients, including fatal/nonfatal MI, cardiac revascularization, and cardiovascular death, into a simple risk score. Predictors of MACE were obtained from a prospective observational cohort study, including 1019 AF patients taking vitamin K antagonists from the Atherothrombosis Center, of Sapienza University of Rome...
March 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26465220/hepatic-compartment-syndrome-following-percutaneous-cholecystostomy-a-case-report
#13
Fanny Marcaire, François Malavieille, Virginie Pichot-Delahaye, Bernard Floccard, Thomas Rimmelé
OBJECTIVE: To describe a case of hepatic subcapsular hematoma causing an acute Budd-Chiari-like syndrome, leading to hepatic compartment syndrome, which combines compression of intrahepatic vessels on CT, acute liver failure, and refractory shock. DESIGN: Case report. SETTING: Surgical ICU of a university teaching hospital. PATIENT: Single case: A 64-year-old man hospitalized for 1 month in the ICU after multiple complications following bypass surgery, under anticoagulation after a recent aortic valve replacement and without a medical history of hepatic disease, underwent a percutaneous cholecystostomy for acute calculous cholecystitis...
March 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26207980/fetal-growth-restriction-and-intra-uterine-growth-restriction-guidelines-for-clinical-practice-from-the-french-college-of-gynaecologists-and-obstetricians
#14
C Vayssière, L Sentilhes, A Ego, C Bernard, D Cambourieu, C Flamant, G Gascoin, A Gaudineau, G Grangé, V Houfflin-Debarge, B Langer, V Malan, P Marcorelles, J Nizard, F Perrotin, L Salomon, M-V Senat, A Serry, V Tessier, P Truffert, V Tsatsaris, C Arnaud, B Carbonne
Small for gestational age (SGA) is defined by weight (in utero estimated fetal weight or birth weight) below the 10th percentile (professional consensus). Severe SGA is SGA below the third percentile (professional consensus). Fetal growth restriction (FGR) or intra-uterine growth restriction (IUGR) usually correspond with SGA associated with evidence indicating abnormal growth (with or without abnormal uterine and/or umbilical Doppler): arrest of growth or a shift in its rate measured longitudinally (at least two measurements, 3 weeks apart) (professional consensus)...
October 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26142297/metabolic-syndrome-atrial-fibrillation-and-stroke-tackling-an-emerging-epidemic
#15
REVIEW
Reza Hajhosseiny, Gareth K Matthews, Gregory Y H Lip
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle...
November 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25838591/anaesthetic-concerns-during-adrenalectomy-for-cushing-s-syndrome-with-known-hyperhomocysteinemia
#16
Nirmala Jonnavithula, Praveen Reddy Elmati, Kiran Kumar Duddu, Pvln Murthy, Gopinath Ramachandran
Maintenance of homeostasis during anaesthesia in the patient with two major metabolic disorders whose systemic effects either compliment or contradict each other is a challenge to the anaesthesiologist. A 25-year-old male patient with Cushing's syndrome and known hyperhomocysteinemia was scheduled for open adrenalectomy. Both these disorders compound the hypercoagulable state and differ in glucose metabolism. In addition, obesity, difficult airway, electrolyte and metabolic derangements that accompany Cushing's syndrome warrant special attention...
March 2015: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/25794247/treatment-of-severe-metabolic-alkalosis-with-continuous-renal-replacement-therapy-bicarbonate-kinetic-equations-of-clinical-value
#17
Lenar Yessayan, Jerry Yee, Stan Frinak, David Kwon, Balazs Szamosfalvi
Concomitant severe metabolic alkalosis, hypernatremia, and kidney failure pose a therapeutic challenge. Hemodialysis to correct azotemia and abnormal electrolytes results in rapid correction of serum sodium, bicarbonate, and urea but presents a risk for dialysis disequilibrium and brain edema. We describe a patient with Zollinger-Ellison syndrome with persistent encephalopathy, severe metabolic alkalosis (highest bicarbonate 81 mEq/L), hypernatremia (sodium 157 mEq/L), and kidney failure despite 30 hours of intravenous crystalloids and proton pump inhibitor...
July 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/25774325/chorea-associated-with-high-titers-of-antiphospholipid-antibodies-in-the-absence-of-antiphospholipid-antibody-syndrome
#18
Damoun Safarpour, Sarah Buckingham, Bahman Jabbari
BACKGROUND: Chorea associated with high titers of antiphospholipid antibodies in the absence of antiphospholipid antibody syndrome has been seldom reported. CASE REPORT: An 89-year-old female developed persistent right side chorea associated with high titers of anticardiolipin antibody (antiphospholipid antibosies immunoglobulin (Ig)M, 45 MPL and 112 IgM aCL (MPL) after 3 months) but normal lupus anticoagulants. Her magnetic resonance imaging (MRI) showed no abnormality, but positron emission tomography (PET) demonstrated increased bilateral striatal metabolic activity, more on the left side...
2015: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/25429521/incidence-of-myocardial-infarction-and-vascular-death-in-elderly-patients-with-atrial-fibrillation-taking-anticoagulants-relation-to-atherosclerotic-risk-factors
#19
Daniele Pastori, Pasquale Pignatelli, Francesco Angelico, Alessio Farcomeni, Maria Del Ben, Tommasa Vicario, Tommaso Bucci, Valeria Raparelli, Roberto Cangemi, Gaetano Tanzilli, Gregory Y H Lip, Francesco Violi
BACKGROUND: Recent findings suggest that patients with atrial fibrillation (AF), in addition being at thromboembolic risk, are at risk of myocardial infarction (MI). Our aim was to investigate predictors of MI and cardiovascular death in a cohort of patients with AF who were taking anticoagulants. METHODS: We prospectively followed up 1,019 patients with AF for a median of 33.7 months (3,223 person-years). All patients were treated with oral vitamin K antagonists...
June 2015: Chest
https://www.readbyqxmd.com/read/25289044/azurocidin-induced-inhibition-of-oxygen-metabolism-in-mitochondria-is-antagonized-by-heparin
#20
Liang Wang, Zhiyong Liu, Zhe Dong, Jieyi Pan, Xiaochun Ma
Heparin is a potent blood anticoagulant that has been demonstrated to attenuate inflammatory responses in sepsis. Sepsis is considered to be a microcirculation-mitochondrial distress syndrome. Azurocidin (AZU), a protein with strong heparin-binding potential that induces inflammatory responses and apoptosis, has been shown to increase the permeability of endothelial cells and induce the prognosis of sepsis. However, the function of AZU in mitochondrial oxygen metabolism has yet to be reported. The aim of the present study was to investigate whether heparin exhibits an antagonistic effect on AZU-induced mitochondrial dysfunction in human umbilical vein endothelial cells (HUVECs) and to further investigate the possible underlying mechanisms...
November 2014: Experimental and Therapeutic Medicine
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