keyword
MENU ▼
Read by QxMD icon Read
search

HIV Integration

keyword
https://www.readbyqxmd.com/read/28235021/plasma-nevirapine-concentrations-predict-virological-and-adherence-failure-in-kenyan-hiv-1-infected-patients-with-extensive-antiretroviral-treatment-exposure
#1
Maureen J Kimulwo, Javan Okendo, Rashid A Aman, Bernhards R Ogutu, Gilbert O Kokwaro, Dorothy J Ochieng, Anne W T Muigai, Florence A Oloo, Washingtone Ochieng
Treatment failure is a key challenge in the management of HIV-1 infection. We conducted a mixed-model survey of plasma nevirapine (NVP) concentrations (cNVP) and viral load in order to examine associations with treatment and adherence outcomes among Kenyan patients on prolonged antiretroviral therapy (ART). Blood plasma was collected at 1, 4 and 24 hours post-ART dosing from 58 subjects receiving NVP-containing ART and used to determine cNVP and viral load (VL). Median duration of treatment was 42 (range, 12-156) months, and 25 (43...
2017: PloS One
https://www.readbyqxmd.com/read/28231670/-factors-associated-with-marital-status-among-spouse-after-diagnosed-in-newly-reported-hiv-cases-in-china-2014
#2
J Li, J Xu, H L Tang, J Han, Y R Mao
Objective: To analyze the factors associated with divorce or separation when one of the spouse diagnosed and newly reported as HIV positive, in China. Methods: Data from the Chinese HIV/AIDS Comprehensive Response Information Management System, by December 31, 2015 were used for collection on newly reported HIV cases regarding their baseline information in 2014 and follow-up within one year, among couples and above 18 year olds. HIV cases were divided into divorce/separation group and married group according to their marriage dynamics in one year after being diagnosed as HIV positive...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231258/depressive-symptoms-in-hiv-infected-and-seronegative-control-subjects-in-cameroon-effect-of-age-education-and-gender
#3
Georgette D Kanmogne, Fang Qiu, Félicien E Ntone, Julius Y Fonsah, Dora M Njamnshi, Callixte T Kuate, Roland F Doh, Anne M Kengne, Claude T Tagny, Emilienne Nchindap, Léopoldine Kenmogne, Dora Mbanya, Mariana Cherner, Robert K Heaton, Alfred K Njamnshi
Depression is a leading cause of HIV/AIDS disease burden; it worsens health outcomes and quality of life. Addressing this problem requires accurate quantification of the extra burden of depression to HIV/AIDS in a given population, and knowledge of the baseline depression prevalence in the general population. There has been no previous study of depression in the general Cameroonian population. The current study attempts to address that important need. We used the Beck Depression Inventory-II to assess the prevalence and severity of depressive symptoms in 270 HIV-infected and seronegative Cameroonians...
2017: PloS One
https://www.readbyqxmd.com/read/28229244/prevalence-and-correlates-of-use-of-safer-conception-methods-in-a-prospective-cohort-of-ugandan-hiv-affected-couples-with-fertility-intentions
#4
Glenn J Wagner, Sebastian Linnemayr, Kathy Goggin, Deborah Mindry, Jolly Beyeza-Kashesya, Sarah Finocchario-Kessler, Eric Robinson, Josephine Birungi, Rhoda K Wanyenze
We examined the prevalence and correlates of safer conception methods (SCM) use in HIV-affected couples with fertility intentions. A prospective cohort of 400 HIV clients in Uganda who had fertility intentions with their partner was surveyed every 6 months for 24 months. Logistic regression analysis was used to determine individual, relationship and provider level predictors of SCM use. Over one-third (35%) reported any use of timed unprotected intercourse (TUI) during the study; use of other SCM was rare...
February 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28226058/health-literacy-for-people-living-with-hiv-aids-an-integrative-review
#5
Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão, Patrícia Neyva da Costa Pinheiro, Neiva Francenely Cunha Vieira
Objective: to analyze knowledge produced by research about health literacy for adult with HIV/Aids. Method: an integrative literature review, using six databases, was conducted between January and April of 2014. The descriptors aids and Health Literacy were used, in Portuguese, English and Spanish. A total of 130 articles were found and 14 were selected. Three categories were identified: educational technologies and health literacy for HIV/Aids; assessment of health literacy of patients with HIV/Aids; and health literacy and adherence to antiretroviral therapy...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28225803/bacterial-expression-correct-membrane-targeting-and-functional-folding-of-the-hiv-1-membrane-protein-vpu-using-a-periplasmic-signal-peptide
#6
Arpan Deb, William A Johnson, Alexander P Kline, Boston J Scott, Lydia R Meador, Dustin Srinivas, Jose M Martin-Garcia, Katerina Dörner, Chad R Borges, Rajeev Misra, Brenda G Hogue, Petra Fromme, Tsafrir S Mor
Viral protein U (Vpu) is a type-III integral membrane protein encoded by Human Immunodeficiency Virus-1 (HIV- 1). It is expressed in infected host cells and plays several roles in viral progeny escape from infected cells, including down-regulation of CD4 receptors. But key structure/function questions remain regarding the mechanisms by which the Vpu protein contributes to HIV-1 pathogenesis. Here we describe expression of Vpu in bacteria, its purification and characterization. We report the successful expression of PelB-Vpu in Escherichia coli using the leader peptide pectate lyase B (PelB) from Erwinia carotovora...
2017: PloS One
https://www.readbyqxmd.com/read/28225344/tuberculosis-among-the-homeless-should-we-change-the-strategy
#7
M Dias, R Gaio, P Sousa, M Abranches, M Gomes, O Oliveira, M Correia-Neves, E Ferreira, R Duarte
BACKGROUND: Tuberculosis (TB) is a major concern among high-risk populations such as the homeless. OBJECTIVES: To evaluate TB incidence and treatment outcomes among homeless patients in Portugal and to identify predictors of unsuccessful TB treatment outcomes among the homeless. DESIGN: This was a retrospective cohort study of all TB patients notified in Portugal from 2008 to 2014. Characteristics of homeless TB patients were assessed and predictors of unsuccessful TB treatment were determined using logistic regression...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225335/integrating-tuberculosis-screening-in-kenyan-prevention-of-mother-to-child-transmission-programs
#8
L M Cranmer, A Langat, K Ronen, C J McGrath, S LaCourse, J Pintye, B Odeny, B Singa, A Katana, L Nganga, J Kinuthia, G John-Stewart
BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS: As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-to-size sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224134/cervical-cancer-screening-in-rural-south-africa-among-hiv-infected-migrant-farm-workers-and-sex-workers
#9
Omara Afzal, Molly Lieber, Peter Dottino, Ann Marie Beddoe
At an HIV clinic in the Limpopo province of South Africa, chart reviews revealed long delays in addressing abnormal Pap smears, difficulty in referrals, poor quality and lost results, and increasing cases of cervical cancer. To address these barriers, a "see and treat" approach to screening was proposed. The objective was to integrate this method into current HIV care offered by local providers and to obtain demographic and risk factor data for use in future educational and intervention programs in the region...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28222782/identification-of-mirna-mrna-crosstalk-in-cd4-t-cells-during-hiv-1-infection-by-integrating-transcriptome-analyses
#10
Qibin Liao, Jin Wang, Zenglin Pei, Jianqing Xu, Xiaoyan Zhang
BACKGROUND: HIV-1-infected long-term nonprogressors (LTNPs) are characterized by infection with HIV-1 more than 7-10 years, but keeping high CD4(+) T cell counts and low viral load in the absence of antiretroviral treatment, while loss of CD4(+) T cells and high viral load were observed in the most of HIV-1-infected individuals with chronic progressors (CPs) However, the mechanisms of different clinical outcomes in HIV-1 infection needs to be further resolved. METHODS: To identify microRNAs (miRNAs) and their target genes related to distinct clinical outcomes in HIV-1 infection, we performed the integrative transcriptome analyses in two series GSE24022 and GSE6740 by GEO2R, R, TargetScan, miRDB, and Cytoscape softwares...
February 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28212984/hiv-1-vpr-disrupts-mitochondria-axonal-transport-and-accelerates-neuronal-aging
#11
Ying Wang, Maryline Santerre, Italo Tempera, Kayla Martin, Ruma Mukerjee, Bassel E Sawaya
Disruption of mitochondria axonal transport, essential for the maintenance of synaptic and neuronal integrity and function, has been identified in neurodegenerative diseases. Whether HIV-1 viral proteins affect mitochondria axonal transport is unknown, albeit HIV-associated neurocognitive disorders occur in around half of the patients living with HIV. Therefore, we sought to examine the effect of HIV-1 viral protein R (Vpr) on mitochondria axonal transport. Using mice primary neuronal cultures, we demonstrated that 4-day Vpr treatment reduced the ratio of moving mitochondria associated with (i) less energy (ATP) supply, (ii) reduction in Miro-1 and (iii) increase of α-synuclein which led to loss of microtubule stability as demonstrated by inconsecutive distribution of acetylated α-tubulin along the axons...
February 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28212645/retrospective-analysis-of-antiretroviral-therapy-uptake-and-retention-of-male-clients-receiving-methadone-maintenance-therapy-in-two-provinces-in-vietnam-potential-synergy-of-the-two-therapies
#12
Linh Thi Thuy Pham, Akiko Kitamura, Hoa Mai Do, Kim Anh Lai, Nhan Tuan Le, Van Thi Thuy Nguyen, Masaya Kato
BACKGROUND: Vietnam has a concentrated HIV epidemic with injection drug use being the dominant mode of HIV transmission. Vietnam has rapidly expanded antiretroviral therapy (ART) and methadone maintenance therapy (MMT). This study aims to analyze ART uptake and retention among male clients receiving MMT in Vietnam in the early phase of the MMT program. METHODS: The male clients (age ≥18) who were newly enrolled in care or started ART at two HIV clinics in Hanoi (2009 to 2011) and three HIV clinics in Can Tho (2010 to 2012) were included for the analysis...
February 17, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28210784/novel-aids-therapies-based-on-gene-editing
#13
REVIEW
Kamel Khalili, Martyn K White, Jeffrey M Jacobson
HIV/AIDS remains a major public health issue. In 2014, it was estimated that 36.9 million people are living with HIV worldwide, including 2.6 million children. Since the advent of combination antiretroviral therapy (cART), in the 1990s, treatment has been so successful that in many parts of the world, HIV has become a chronic condition in which progression to AIDS has become increasingly rare. However, while people with HIV can expect to live a normal life span with cART, lifelong medication is required and cardiovascular, renal, liver, and neurologic diseases are still possible, which continues to prompt research for a cure for HIV...
February 16, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28209198/distribution-and-fate-of-hiv-1-unintegrated-dna-species-a-comprehensive-update
#14
REVIEW
Faysal Bin Hamid, Jinsun Kim, Cha-Gyun Shin
Reverse transcription of viral RNA and the subsequent integration of reverse transcripts are the classical early events of the HIV-1 life-cycle. Simultaneously, abundant unintegrated DNAs (uDNAs), are formed in cells ubiquitously. The uDNAs either undergo recombination or degradation or persist inactively for long periods in the nucleus as future resources. Among them, 2-LTR circles are considered a dead-end for viral spread. Their contribution to the HIV-1 infection is still poorly understood. Nevertheless, the preintegration transcription of the aberrant DNAs and the consequent alterations of cellular factors have already been reported...
February 16, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28207844/population-attributable-fraction-of-incident-hiv-infections-associated-with-alcohol-consumption-in-fishing-communities-around-lake-victoria-uganda
#15
Noah Kiwanuka, Ali Ssetaala, Ismail Ssekandi, Annet Nalutaaya, Paul Kato Kitandwe, Julius Ssempiira, Bernard Ssentalo Bagaya, Apolo Balyegisawa, Pontiano Kaleebu, Judith Hahn, Christina Lindan, Nelson Kaulukusi Sewankambo
BACKGROUND: Although the association between alcohol consumption and HIV risk is well documented, few studies have examined the magnitude of new HIV infections that could be prevented by controlling alcohol use. We report the population attributable fraction (PAF) of incident HIV infections due to alcohol consumption among the HIV high-risk population of fishing communities along Lake Victoria, Uganda. METHODS: In a community-based cohort study, 1607 HIV sero-negative participants aged 18-49 years were enrolled from eight fishing communities along Lake Victoria, Uganda...
2017: PloS One
https://www.readbyqxmd.com/read/28203108/a-review-of-screening-strategies-for-cervical-cancer-in-human-immunodeficiency-virus-positive-women-in-sub-saharan-africa
#16
REVIEW
Manuela Viviano, Pierre DeBeaudrap, Pierre-Marie Tebeu, Jovanny T Fouogue, Pierre Vassilakos, Patrick Petignat
Cervical cancer (CC) is a leading cause of cancer-related death and a major public health issue in sub-Saharan Africa. This heavy burden parallels that of the human immunodeficiency virus (HIV) infection, which increases the risk of developing CC. Despite the progressive reduction of HIV prevalence in the past decade, the CC incidence and mortality rates in sub-Saharan Africa remain high. The heterogeneity of the distribution of the two diseases in the African continent, together with the different availability of human and material resources, stands in the way of finding an appropriate screening strategy...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28196085/what-device-would-be-best-for-early-infant-male-circumcision-in-east-and-southern-africa-provider-experiences-and-opinions-with-three-different-devices-in-kenya
#17
Robert C Bailey, Irene Nyaboke, Fredrick O Otieno
Voluntary medical male circumcision (VMMC) reduces risk of HIV acquisition in heterosexual men by approximately 60%. As some countries approach targets for proportions of adolescents and adults circumcised, some are considering early infant male circumcision (EIMC) as a means to achieve sustainability of VMMC for long term reduction of HIV incidence. Evaluations of specialized devices for EIMC are important to provide programs with information required to make informed decisions about how to design safe, effective EIMC programs...
2017: PloS One
https://www.readbyqxmd.com/read/28195779/ehealth-literacy-and-intervention-tailoring-impacts-the-acceptability-of-a-hiv-sti-testing-intervention-and-sexual-decision-making-among-young-gay-and-bisexual-men
#18
Keith J Horvath, José A Bauermeister
We assessed whether young men who have sex with men's acceptability with the online Get Connected! intervention and subsequent sexual health decision making were influenced by their baseline eHealth literacy (high vs. low competency) and intervention tailoring (tailored or nontailored intervention condition). Compared to the high eHealth literacy/tailored intervention group: (1) those in the low eHealth literacy/tailored intervention condition and participants in the nontailored intervention condition (regardless of eHealth literacy score) reported lower intervention information quality scores; and (2) those in the low eHealth literacy/nontailored intervention group reported lower intervention system quality scores and that the intervention had less influence on their sexual health decision making...
February 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28194585/prevalence-and-associations-of-psychological-distress-hiv-infection-and-hiv-care-service-utilization-in-east-zimbabwe
#19
Malebogo Tlhajoane, Jeffrey W Eaton, Albert Takaruza, Rebecca Rhead, Rufurwokuda Maswera, Nadine Schur, Lorraine Sherr, Constance Nyamukapa, Simon Gregson
The correlation between mental health and sexual risk behaviours for HIV infection remains largely unknown in low and middle income settings. The present study determined the prevalence of psychological distress (PD) in a sub-Saharan African population with a generalized HIV epidemic, and investigated associations with HIV acquisition risk and uptake of HIV services using data from a cross-sectional survey of 13,252 adults. PD was measured using the Shona Symptom Questionnaire. Logistic regression was used to measure associations between PD and hypothesized covariates...
February 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28193290/transitional-care-for-formerly-incarcerated-persons-with-hiv-protocol-for-a-realist-review
#20
Jenkin Tsang, Sharmistha Mishra, Janet Rowe, Patricia O'Campo, Carolyn Ziegler, Fiona G Kouyoumdjian, Flora I Matheson, Ahmed M Bayoumi, Shatabdy Zahid, Tony Antoniou
BACKGROUND: Little is known about the mechanisms that influence the success or failure of programs to facilitate re-engagement with health and social services for formerly incarcerated persons with HIV. This review aims to identify how interventions to address such transitions work, for whom and under what circumstances. METHODS: We will use realist review methodology to conduct our analysis. We will systematically search electronic databases and grey literature for English language qualitative and quantitative studies of interventions...
February 13, 2017: Systematic Reviews
keyword
keyword
2399
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"