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https://www.readbyqxmd.com/read/29352519/nafamostat-mesilate-attenuates-inflammation-and-apoptosis-and-promotes-locomotor-recovery-after-spinal-cord-injury
#1
Hui-Quan Duan, Qiu-Li Wu, Xue Yao, Bao-You Fan, Hong-Yu Shi, Chen-Xi Zhao, Yan Zhang, Bo Li, Chao Sun, Xiao-Hong Kong, Xin-Fu Zhou, Shi-Qing Feng
AIM: Spinal cord injury (SCI) leads to severe neural damage for which there is currently no effective treatment. Exploration of the neuroprotective effect among clinically approved drugs will speed up clinical translation of SCI. Nafamostat mesilate (NM) as a synthetic serine protease inhibitor has been used clinically in pancreatitis treatments. However, its effectiveness in SCI is unknown. The aim of this study was to confirm the efficacy of NM in ameliorating SCI. METHODS: Intraperitoneal administration of NM was performed on a contusion SCI model in Wistar rat...
January 19, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29352445/effect-of-sevoflurane-anesthesia-on-brain-is-mediated-by-lncrna-hotair
#2
Jian-Yue Wang, Yong Feng, Yan-Hong Fu, Guang-Li Liu
Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using inhaled anesthetics like sevoflurane, it is important to understand how their usage results in neurotoxicity and subsequently devise ways to circumvent or attenuate the anesthetic-mediated induction in neurotoxicity. Long noncoding RNAs (LncRNAs) are a group of > 200 bp long RNAs and show specific spatiotemporal expression profiles...
January 19, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29350427/role-of-microglia-in-the-spinal-cord-in-colon-to-bladder-neural-crosstalk-in-a-rat-model-of-colitis
#3
Tsuyoshi Majima, Yasuhito Funahashi, Naoki Kawamorita, Shun Takai, Yoshihisa Matsukawa, Tokunori Yamamoto, Naoki Yoshimura, Momokazu Gotoh
AIMS: We investigated whether spinal cord microglia are involved in colon-to-bladder neural crosstalk in a rat model of colitis. METHODS: Adult female SD rats were divided into A) control, B) colitis, and C) colitis + minocycline groups. Experimental colitis was induced by administering 50% trinitrobenzene sulfonic acid into the distal colon in the colitis group and the minocycline group. Minocycline, a microglial inhibitor, was continuously infused into the intrathecal space in the minocycline group...
January 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29350074/serum-concentration-and-clinical-significance-of-brain-derived-neurotrophic-factor-in-patients-with-parkinson-s-disease-or-essential-tremor
#4
Yixian Huang, Wenwei Yun, Min Zhang, Weifeng Luo, Xianju Zhou
Objectives The serum concentration of brain-derived neurotrophic factor (BDNF) was compared among patients with Parkinson's disease (PD), patients with essential tremor (ET), and healthy participants, and its association with clinical features of PD and ET was assessed. Methods Demographic and clinical data were collected from 60 patients with PD at different clinical stages, 60 patients with ET, and 60 controls. All participants' serum BDNF concentrations were measured. Their motor abilities and activity were assessed by the Unified PD Rating Scale and the Hoehn and Yahr (H-Y) staging scale...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29349576/prep1-deficiency-affects-olfactory-perception-and-feeding-behavior-by-impairing-bdnf-trkb-mediated-neurotrophic-signaling
#5
Serena Ricci, Davide Viggiano, Ilaria Cimmino, Giuseppe Perruolo, Serena Cabaro, Antonietta Liotti, Francesca Fiory, Rosa Spinelli, Angelina Di Carlo, Francesco Beguinot, Pietro Formisano, Francesco Oriente
Prep1 is a homeodomain transcription factor which has an important role in hindbrain development. Prep1 expression is also kept in adult mouse brain and in particular within the olfactory bulbs. Moreover, many Prep1 neurons co-localize with Calbindin-positive periglomerular interneurons in olfactory glomerular layer. However, Prep1 function in this brain region is still unknown. In this study, we show that Prep1 hypomorphic heterozygous (Prep1 i/+ ) mice express low levels of protein and feature a 30% reduction of olfactory bulb area, compared to WT mice...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29348904/role-of-tissue-type-plasminogen-activator-and-plasminogen-activator-inhibitor-1-in-psychological-stress-and-depression
#6
REVIEW
Shih-Jen Tsai
Major depressive disorder is a common illness worldwide, but the pathogenesis of the disorder remains incompletely understood. The tissue-type plasminogen activator-plasminogen proteolytic cascade is highly expressed in the brain regions involved in mood regulation and neuroplasticity. Accumulating evidence from animal and human studies suggests that tissue-type plasminogen activator and its chief inhibitor, plasminogen activator inhibitor-1, are related to stress reaction and depression. Furthermore, the neurotrophic hypothesis of depression postulates that compromised neurotrophin brain-derived neurotrophic factor (BDNF) function is directly involved in the pathophysiology of depression...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348190/pronounced-hyperactivity-cognitive-dysfunctions-and-bdnf-dysregulation-in-dopamine-transporter-knockout-rats
#7
Damiana Leo, Ilya Sukhanov, Francesca Zoratto, Placido Illiano, Lucia Caffino, Fabrizio Sanna, Giulia Messa, Marco Emanuele, Alessandro Esposito, Maria Dorofeikova, Evgeny A Budygin, Liudmila Mus, Evgenia E Efimova, Marco Niello, Stefano Espinoza, Tatyana D Sotnikova, Marius C Hoener, Gianni Laviola, Fabio Fumagalli, Walter Adriani, Raul R Gainetdinov
Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder (ADHD). The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats (DAT-knockout, DAT-KO rats) in which the gene encoding the DAT has been disrupted by using zinc finger nuclease technology (ZFN)...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29346609/decreased-serum-levels-of-ghrelin-and-brain-derived-neurotrophic-factor-in-premenopausal-women-with-metabolic-syndrome
#8
Masoumeh Jabbari, Sorayya Kheirouri, Mohammad Alizadeh
Objective: We aimed to investigate the association between serum levels of ghrelin and brain-derived neurotrophic factor (BDNF) with MetS and its components in premenopausal women. Methods: 43 patients with MetS and 43 healthy controls participated in this study. Participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-C and HDL-C), fasting blood sugar (FBS), insulin, BDNF and ghrelin determined...
January 12, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29345295/upregulation-of-the-bdnf-trkb-pathway-promotes-epithelial-mesenchymal-transition-as-well-as-the-migration-and-invasion-of-cervical-cancer
#9
Yuan Yuan, Hai-Qiong Ye, Qian-Chuan Ren
Brain-derived neurotrophic factor (BDNF) has previously been demonstrated to be associated with several types of cancer. In addition, its receptor, tropomyosin related kinase B (TrkB) is involved in tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) is associated with metastasis in cancers. Thus, The aim of the present study was to examine whether BDNF/TrKB expression is linked to a poor survival and the acquisition of the EMT phenotype in cervical cancer. We found that a high positive expression of BDNF/TrKB was associated with poor survival in cervical cancer...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344422/the-effects-of-physical-training-are-varied-and-occur-in-an-exercise-type-dependent-manner-in-elderly-men
#10
Mari L Sbardelotto, Giulia S Pedroso, Fernanda T Pereira, Helen R Soratto, Stella Ms Brescianini, Pauline S Effting, Anand Thirupathi, Renata T Nesi, Paulo Cl Silveira, Ricardo A Pinho
Regular exercise can decrease the deleterious effects of aging and limit the development and progression of chronic disease in elderly people, depending on the type, intensity, frequency, and duration of exercise. This study aimed to investigate the potential protective effects of different physical training programs on oxidative stress parameters and inflammatory and neurotrophic mediators in the serum of elderly men. Healthy male volunteers [60 to 80 years; n=55] were divided into four groups: control [Ctr, n=14], aerobic training on dry land [ATdl, n=12]; and combined training on dry land [CTdl, n=12] or in water [CTw, n=17]...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344238/sophoridine-suppresses-cell-growth-in-human-medulloblastoma-through-foxm1-nf-%C3%AE%C2%BAb-and-ap-1
#11
Zhensong Yue, Tongguo Si, Zhanyu Pan, Wenfeng Cao, Zhuchen Yan, Zhansheng Jiang, Huaqiang Ouyang
Sophoridine is an alkaloid extracted from Sophora alopecuroides that has extensive pharmacological actions. In the present study, the effect of sophoridine on cell growth of human medulloblastoma and its mechanism were investigated. Human medulloblastoma D283-Med cells were incubated with 0, 0.5, 1 or 2 mg/ml sophoridine for 24, 48 or 72 h. Cell proliferation and cytotoxicity were analyzed using MTT and lactate dehydrogenase assays, respectively. Next, analyses of cell apoptosis and caspase-3/8 activity were performed using flow cytometry or spectrophotometry, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343707/sensory-neuronal-p2rx4-receptors-controls-bdnf-signaling-in-inflammatory-pain
#12
Sarah Lalisse, Jennifer Hua, Manon Lenoir, Nathalie Linck, François Rassendren, Lauriane Ulmann
Chronic inflammatory and neuropathic pains are major public health concerns. Potential therapeutic targets include the ATP-gated purinergic receptors (P2RX) that contribute to these pathological types of pain in several different cell types. The purinergic receptors P2RX2 and P2RX3 are expressed by a specific subset of dorsal root ganglion neurons and directly shape pain processing by primary afferents. In contrast the P2RX4 and P2RX7 are mostly expressed in myeloid cells, where activation of these receptors triggers the release of various pro-inflammatory molecules...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342845/anesthetic-preconditioning-as-endogenous-neuroprotection-in-glaucoma
#13
Tsung-Han Chou, Ganeswara Rao Musada, Giovanni Luca Romano, Elizabeth Bolton, Vittorio Porciatti
Blindness in glaucoma is the result of death of Retinal Ganglion Cells (RGCs) and their axons. RGC death is generally preceded by a stage of reversible dysfunction and structural remodeling. Current treatments aimed at reducing intraocular pressure (IOP) are ineffective or incompletely effective in management of the disease. IOP-independent neuroprotection or neuroprotection as adjuvant to IOP lowering in glaucoma remains a challenge as effective agents without side effects have not been identified yet. We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342042/long-term-administration-of-salicylate-induced-changes-in-bdnf-expression-and-creb-phosphorylation-in-the-auditory-cortex-of-rats
#14
Bin Yi, Cong Wu, Runjie Shi, Kun Han, Haibin Sheng, Bei Li, Ling Mei, Xueling Wang, Zhiwu Huang, Hao Wu
HYPOTHESIS: We investigated whether salicylate induces tinnitus through alteration of the expression levels of brain-derived neurotrophic factor (BDNF), proBDNF, tyrosine kinase receptor B (TrkB), cAMP-responsive element-binding protein (CREB), and phosphorylated CREB (p-CREB) in the auditory cortex (AC). BACKGROUND: Salicylate medication is frequently used for long-term treatment in clinical settings, but it may cause reversible tinnitus. Salicylate-induced tinnitus is associated with changes related to central auditory neuroplasticity...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29341893/targeting-bdnf-modulation-by-plant-glycosides-as-a-novel-therapeutic-strategy-in-the-treatment-of-depression
#15
REVIEW
Haroon Khan, Surriya Amin, Seema Patel
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of this review is to focus on the antidepressant effects of glycosides in preclinical studies, with an emphasis on the possible mechanisms. The literature search revealed that only a few phytoglycosides have been evaluated for their relevance in depression alleviation...
January 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29341465/p2y12-deficiency-in-mouse-impairs-noradrenergic-system-in-brain-and-alters-anxiety-like-neurobehavior-and-memory
#16
Fang Zheng, Qiang Zhou, Yin Cao, Hailian Shi, Hui Wu, Beibei Zhang, Fei Huang, Xiaojun Wu
Purinergic receptor P2Y12 (P2Y12 ), a G protein-coupled (GPCR) purinergic receptor, is widely distributed in nervous system and involved in the progression of neurological diseases such as multiple sclerosis and neuropathic pain. The central noradrenergic system actively participates in a number of neurophysiological processes. Nevertheless, whether there is any direct relevance between P2Y12 and noradrenergic signal transduction remains unknown. In the present study, we tested the hypothesis that lack of P2Y12 impaired noradrenergic signal transduction in mouse brain...
January 17, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29340106/a-maternal-high-fat-diet-during-pregnancy-and-lactation-in-addition-to-a-postnatal-high-fat-diet-leads-to-metabolic-syndrome-with-spatial-learning-and-memory-deficits-beneficial-effects-of-resveratrol
#17
Shih-Wen Li, Hong-Ren Yu, Jiunn-Ming Sheen, Mao-Meng Tiao, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Kow-Aung Chang, Ching-Chou Tsai, Li-Tung Huang
We tested the hypothesis that high-fat diet consumption during pregnancy, lactation, and/or post weaning, altered the expression of molecular mediators involved in hippocampal synaptic efficacy and impaired spatial learning and memory in adulthood. The beneficial effect of resveratrol was assessed. Dams were fed a rat chow diet or a high-fat diet before mating, during pregnancy, and throughout lactation. Offspring were weaned onto either a rat chow or a high-fat diet. Four experimental groups were generated, namely CC, HC, CH, and HH (maternal chow diet or high-fat diet; postnatal chow diet or high-fat diet)...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339786/integrated-mirna-mrna-spatial-signature-for-oral-squamous-cell-carcinoma-a-prospective-profiling-study-of-narrow-band-imaging-guided-resection
#18
Camile S Farah, Simon A Fox, Andrew J Dalley
Oral squamous cell carcinoma (OSCC) is a common malignancy for which there is poor prognosis and limited therapeutic options. The objective was to identify mRNA targets of dysregulated miRNAs in OSCC using integrated analysis and understand molecular abnormality in surgical margins. We used biopsies along the spatial axis from normal tissue defined by narrow band imaging (NBI) through conventional white light (WL) margins to tumour from 18 patients undergoing surgical resection for OSCC. Overall 119 miRNA and 4794 mRNA were differentially expressed along the adjacent normal tissue to tumour axis...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339649/cardiovascular-risk-factors-and-insulin-resistance-after-two-hypocaloric-diets-with-different-fat-distribution-in-obese-subjects-effect-of-the-rs10767664-gene-variant-in-brain-derived-neurotrophic-factor
#19
Daniel Antonio de Luis, Enrique Romero, Olatz Izaola, David Primo, Rocío Aller
BACKGROUND: The role of brain-derived neurotrophic factor (BDNF) variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients. OBJECTIVE: Our aim was to analyze the effects of the rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels after a high monounsaturated fatty acids (MUFAs) hypocaloric diet (diet M) versus a high polyunsaturated fatty acids (PUFAs) hypocaloric diet (diet P)...
January 17, 2018: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29339100/genetic-variation-in-the-dopamine-system-influences-intervention-outcome-in-children-with-cerebral-palsy
#20
Rochellys Diaz Heijtz, Rita Almeida, Ann Christin Eliasson, Hans Forssberg
BACKGROUND: There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation success. We examined whether naturally occurring variations in dopamine and BDNF genes influenced the treatment outcomes. METHODS: Thirty-three children (18-60months of age) with spastic unilateral cerebral palsy were enrolled in the study...
January 9, 2018: EBioMedicine
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