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Alicja Pacholewska, Núria Mach, Xavier Mata, Anne Vaiman, Laurent Schibler, Eric Barrey, Vincent Gerber
BACKGROUND: MiRNAs regulate multiple genes at the post-transcriptional level and therefore play an important role in many biological processes. It has been suggested that miRNA exported outside the cells contribute to inter-cellular communication. Consequently, circulating miRNAs are of particular interest and are promising biomarkers for many diseases. The number of miRNAs annotated in the horse genome is much lower compared to model organisms like human and mouse. We therefore aimed to identify novel equine miRNAs for tissue types and breed in serum...
October 26, 2016: BMC Genomics
Se Ang Jang, Young Ho Cho, Young Soo Byun, Tae Hoe Gu
Abductor deficiency in native hip joint may cause severe limping and pain. It is more serious situation in case of arthroplasty due to instability and recurrent dislocation. Well-known causes of abductor deficiency are repeated surgery, chronic trochanteric bursitis, superior gluteal nerve injury, failure of repair of abductor tendon insertion to the greater trochanter. Author had experienced primary abductor deficiency during total hip replacement and treated successfully with the transfer of gluteus maximus...
September 2016: Hip Pelvis
Susanne Lütje, Sebastian Blex, Benedikt Gomez, Benedikt M Schaarschmidt, Lale Umutlu, Michael Forsting, Walter Jentzen, Andreas Bockisch, Thorsten D Poeppel, Axel Wetter
OBJECTIVE: The aim of this optimization study was to minimize the acquisition time of 68Ga-HBED-CC-PSMA positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with local and metastatic prostate cancer (PCa) to obtain a sufficient image quality and quantification accuracy without any appreciable loss. METHODS: Twenty patients with PCa were administered intravenously with the 68Ga-HBED-CC-PSMA ligand (mean activity 99 MBq/patient, range 76-148 MBq) and subsequently underwent PET/MRI at, on average, 168 min (range 77-320 min) after injection...
2016: PloS One
Alexandre Terrier, Valérie Parvex, Hannes A Rüdiger
INTRODUCTION: In total hip arthroplasty, cup medialisation with compensatory increase of femoral offset has been proposed to increase the moment arms of abductor muscles. However, this technique is associated with a loss of acetabular bone stock. Previous data indicates that the potential benefit is not constant among patients and is likely related to patient anatomy. METHOD: Therefore, to be able to select patients who would benefit most from this technique, we measured several anatomical parameters of the pelvis and femur in 15 patients; and evaluated correlations between them and the changes of moment arms associated with cup medialisation...
October 8, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Gulcan Harput, Jennifer Sebert Howard, Carl Mattacola
Study Design Cross-sectional, controlled laboratory study. Background Quantification of muscular activation during different phases of functional activities is important to understand activation deficits in individuals who have undergone anterior cruciate ligament reconstruction (ACLR). Objectives To compare activation levels of vastus medialis (VM), medial hamstrings (MH) and gluteus medius (GMed) muscles during the different phases of weight bearing tasks between individuals who had undergone ACLR and healthy controls...
October 12, 2016: Journal of Orthopaedic and Sports Physical Therapy
Hiroshi Nagahisa, Kazutaka Mukai, Hajime Ohmura, Toshiyuki Takahashi, Hirofumi Miyata
Hypoxic training is believed to increase endurance capacity in association with hypoxia inducible factor-1α (HIF-1α), a modulator of vascular endothelial growth factor-A (VEGF-A), and to influence activation of satellite cells (SCs). However, the effect of hypoxic training on SC activation and its relation to angiogenesis has not been thoroughly investigated. Eight Thoroughbred horses were subjected to normoxic (FIO2 = 21%) or hypoxic (FIO2 = 15%) training for 3 days/week (100%  [Formula: see text]) for 4 weeks...
2016: Oxidative Medicine and Cellular Longevity
Daniel J Kaplan, Andrew P Dold, David J Fralinger, Robert J Meislin
Patients with gluteus minimus and medius tears that fail nonoperative management may be indicated for surgical repair; however, structural failure after gluteal tendon repair remains unacceptably high. This is likely related to the limited healing potential of tendinous tissue, which is poorly vascular and heals by formation of fibrocartilaginous scar tissue rather than histologically normal tendon. An emerging option to augment tendon healing is the use of a bioinductive implant that is designed to amplify the host healing response and induce the formation of healthy tendon tissue...
August 2016: Arthroscopy Techniques
Cynthia Gobbi Alves Araújo, Christiane de Souza Guerino Macedo, Daiene Ferreira, Leonardo Shigaki, Rubens A da Silva
: The purpose of this study was to assess the effect of patellar taping on muscle activation of the knee and hip muscles in women with Patellofemoral Pain Syndrome during five proprioceptive exercises. Forty sedentary women with syndrome were randomly allocated in two groups: Patellar Taping (based in McConnell) and Placebo (vertical taping on patella without any stretching of lateral structures of the knee). Volunteers performed five proprioceptive exercises randomly: Swing apparatus, Mini-trampoline, Bosu balance ball, Anteroposterior sway on a rectangular board and Mediolateral sway on a rectangular board...
September 21, 2016: Journal of Electromyography and Kinesiology
Naiane Teixeira Bastos de Oliveira, Sandra Maria Sbeghen Ferreira Freitas, Fernanda Ferreira Fuhro, Maurício Antônio da Luz Júnior, Cesar Ferreira Amorim, Cristina Maria Nunes Cabral
OBJECTIVE: To determine the amplitude of the electromyographic activity of trunk muscles during Pilates exercises in women with and without chronic low back pain (LBP). DESIGN: Case control study. SETTING: Clinic of a school. PARTICIPANTS: Sixty women divided into LBP Group (LBPG) and Control Group (CG). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Amplitude of the electromyographic activity (root mean square values) of the gluteus maximus and external oblique muscles collected during three Pilates exercises: Shoulder bridge performed in the mat, and Hip roll and Breathing performed in equipment...
September 29, 2016: Archives of Physical Medicine and Rehabilitation
Jose Francisco Rodríguez-Vázquez, Yohei Honkura, Yukio Katori, Gen Murakami, Hiroshi Abe
The existence of hard tissue pulleys that act to change the direction of a muscle insertion tendon is well known in the human body. These include (1) the trochlea for the extraocular obliquus superior muscle, (2) the pterygoid hamulus for the tensor veli palatini muscle, (3) the deep sulcus on the plantar aspect of the cuboid bone for the peroneus longus tendon, (4) the lesser sciatic notch for the obturator internus muscle, and (5) the bony trochleariformis process for the tensor tympani muscle tendon. In addition, (6) the stapedius muscle tendon shows a lesser or greater angulation at the pyramidal eminence of the temporal bone...
September 29, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Bruno Dohin, Elie Haddad, Hassan Al Khoury Salem, Mohamed Merhez Kilani
OBJECTIVE: Hip internal rotation (HIR) during gait is one of the main functional disorders related to cerebral palsy (CP) in children. Most of the procedures proposed rotational osteotomy of the femur (FRO), (and/or tibia). However, multilevel surgery (SEMLS) including bone procedure, implicates more difficult and longer rehabilitation. When bone deformity is moderate, the authors hypothesized that FRO could be avoided. They developed a soft tissues procedure to improve HIR. The aim of the study was assessment of the procedure...
September 2016: Annals of Physical and Rehabilitation Medicine
Maud Pradines, Ingrid Masson, Raphaël Portero, Caroline Giroux, Jean-Michel Gracies
OBJECTIVE: To explore changes in muscle architectural parameters of the muscle-tendon unit of soleus and medial gastrocnemius (GM) in patients with chronic hemiparesis, after 1 year of rehabilitation. MATERIAL/PATIENTS AND METHODS: In this prospective study, 20 chronic hemiparetic patients (8W, mean age: 56 [12], time since lesion 9 [8]) were evaluated. Muscle architectural parameters including muscle fascicle length, pennation angle, thickness, tendon and muscle belly lengths were evaluated in vivo using ultrasonography in passive condition (verified by electromyographic recording) in a seated patient with ankle, knee and hip on the paretic side at 90°...
September 2016: Annals of Physical and Rehabilitation Medicine
Pascal Edouard, Pierrick Arnal, Philippe Gimenez, Pierre Samozino, Pedro Jimenez-Reyes, Matt Brughelli, Jurdan Mendiguchia, Jean-Benoit Morin
OBJECTIVE: The hamstring muscles are the most injured muscles in athletes practicing sprints. However, they seem greatly contributing to the production of horizontal force, a key element in the sprint acceleration performance. The aim of our study was to experimentally analyse the link between the production of horizontal force and strength of the hamstrings at maximum sprints on a treadmill and in fatigue conditions. PATIENTS AND METHODS: Fourteen male subjects accustomed to sprint participated in the experiment consisting in 12 6-seconds sprints separated by 44seconds of recovery on an instrumented treadmill sprint for measuring the horizontal force, coupled with the simultaneous recording of the EMG activity of the vastus lateralis, rectus biceps femoris and gluteus muscles...
September 2016: Annals of Physical and Rehabilitation Medicine
Kristof Kipp, Chad Harris
Lifting greater loads during weightlifting exercises may theoretically be achieved through increasing the magnitudes of net joint impulses or manipulating the joints' effective mechanical advantage (EMA). The purpose of this study was to investigate muscle-specific EMA and joint impulse as well as impulse-momentum characteristics of the lifter-barbell system across a range of external loads during the execution of the clean. Collegiate-level weightlifters performed sub-maximal cleans at 65, 75, and 85% of their 1-repetition maximum (1-RM) while data from a motion analysis system and a force plate were used to calculate lifter-barbell system impulse and velocity, as well as net extensor impulse generated at the hip, knee, and ankle joints and the EMA of the gluteus maximus, hamstrings, quadriceps, and triceps surae muscles...
September 21, 2016: Journal of Strength and Conditioning Research
Kiran Polavarapu, Mahadevappa Manjunath, Veeramani Preethish-Kumar, Deepha Sekar, Seena Vengalil, PriyaTreesa Thomas, Talakad N Sathyaprabha, Rose Dawn Bharath, Atchayaram Nalini
The purpose of this study was to describe the pattern of muscle involvement using MRI findings and correlate with functional as well as muscle strength measurements. Fifty genetically confirmed DMD children with a mean age of 7.6 ± 2.8 (4-15 years) underwent muscle MRI and qualitative assessment was done for muscle changes using Mercuri staging for fibro-fatty replacement on T1 sequence and Borsato score for myoedema on STIR sequence. Detailed phenotypic characterisation was done with Manual muscle testing (modified MRC grading) and Muscular Dystrophy Functional Rating Scale (MDFRS)...
September 5, 2016: Neuromuscular Disorders: NMD
P-L Vincent, B Pinatel, R Viard, J-P Comparin, P Gir, D Voulliaume
AIM OF THE STUDY: The coverage of ischiatic pressure ulcers is characterized by a significant recurrence rate (8-64% depending on the series). It therefore seems necessary to introduce the concept of saving in the use of muscle flaps available to avoid being in a situation of therapeutic impasse. The gluteus maximus inferior split-muscle flap allows a tailored coverage to the ischiatic pressure ulcers grade IV with skin defect less than 8cm after surgical debridement. It is associated with an advancement-rotation skin flap removed above the sub-gluteal fold...
September 21, 2016: Annales de Chirurgie Plastique et Esthétique
Jon A Jacobson, Corrie M Yablon, P Troy Henning, Irene S Kazmers, Andrew Urquhart, Brian Hallstrom, Asheesh Bedi, Aishwarya Parameswaran
OBJECTIVES: The purpose of this study was to compare ultrasound-guided percutaneous tendon fenestration to platelet-rich plasma (PRP) injection for treatment of greater trochanteric pain syndrome. METHODS: After Institutional Review Board approval was obtained, patients with symptoms of greater trochanteric pain syndrome and ultrasound findings of gluteal tendinosis or a partial tear (<50% depth) were blinded and treated with ultrasound-guided fenestration or autologous PRP injection of the abnormal tendon...
September 23, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Weijian Chen, Bo Jiang, Jiaju Zhao, Peiji Wang
This report describes our experiences using the superior gluteal artery perforator (SGAP) flaps for reconstruction of 2 sacral sore cases. A 47-year-old female patient and a  38-year-old man with sacral sores were treated in our unit. The size of the defects were approximately 5×6 cm2  and 8×9 cm2, the  defects were repaired by SGAP flaps. The size of designed was  SGAP flaps varied from  7×20 to 9×16 cm2. All flaps survived and healed primary, the texture, functions, and appearance of flaps were satisfactory, and also without region dysfunction of donor and recipient sites...
October 2016: Saudi Medical Journal
Anna L Hatton, François Hug, Sarah H Chen, Christine Reid, Nicole A Sorensen, Kylie Tucker
Middle-aged adults with painful hip conditions show balance impairments that are consistent with an increased risk of falls. Pathological changes at the hip, accompanied by pain, may accelerate pre-existing age-related balance deficits present in midlife. To consider the influence of pain alone, we investigated the effects of acute experimental hip muscle pain on dynamic single-limb balance in middle-aged adults. Thirty-four healthy adults aged 40-60 years formed two groups (Group-1: n=16; Group-2: n=18). Participants performed four tasks: Reactive Sideways Stepping (ReactSide); Star Excursion Balance Test (SEBT); Step Test; Single-Limb Squat; before and after an injection of hypertonic saline into the right gluteus medius muscle (Group-1) or ∼5min rest (Group-2)...
September 13, 2016: Gait & Posture
Timothy Woo, Thuzar Win
INTRODUCTION: Infantile myofibromatosis (IM) is a rare paediatric fibrous tumour also known as a desmoid tumour that occurs in around 1:150000 live births. It manifests as solitary or multicentric fibrous masses in the musculoaponeurotic soft tissues and can affect the visceral organs and bones. CASE DISCUSSION: We report a case of infantile myofibromatosis of the gluteus maximus muscle in an 18-day old neonate presenting atypically as a case of developmental dysplasia of the hip due to local involvement of the sciatic nerve...
September 7, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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