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https://www.readbyqxmd.com/read/29050631/drug-coated-balloon-treatment-for-femoropopliteal-artery-disease-the-in-pact-global-study-de-novo-in-stent-restenosis-imaging%C3%A2-cohort
#1
Marianne Brodmann, Koen Keirse, Dierk Scheinert, Lubomir Spak, Michael R Jaff, Randy Schmahl, Pei Li, Thomas Zeller
OBJECTIVES: This study sought to evaluate the safety and effectiveness of a paclitaxel-coated drug-coated balloon (DCB) for the treatment of patients with de novo in-stent restenosis (ISR). BACKGROUND: Treatment of patients with ISR remains a challenge. Current strategies are plagued by high rates of recurrent restenosis and need for reintervention. The best intervention for ISR remains to be elucidated. METHODS: The IN.PACT Global study is an independently adjudicated multicenter, prospective, single-arm study that enrolled 1,535 subjects with symptomatic atherosclerotic disease of the superficial femoral and/or popliteal arteries, including de novo ISR lesions...
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29045279/leaflet-kinematics-of-mechanical-and-bioprosthetic-aortic-valve-prostheses
#2
Bernhard Vennemann, Thomas Rösgen, Paul Philipp Heinisch, Dominik Obrist
The hemodynamic performance of artificial aortic valves (AVs) and the probability for structural valve deterioration can be linked to the valve kinematics. Comparability among different studies is limited because of variations in the experimental setups and physiologic boundary conditions. This study presents results of kinematic measurements of bioprosthetic and mechanical AVs that were tested in an identical experimental setting such that they can be directly compared with each other. The kinematics of AVs is typically presented in the form of the geometric orifice area and its temporal evolution...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29042091/effects-of-renal-denervation-on-coronary-flow-reserve-and-forearm-dilation-capacity-in-patients-with-treatment-resistant-hypertension-a-randomized-double-blinded-sham-controlled-clinical-trial
#3
Morten Engholm, Jannik B Bertelsen, Ole N Mathiassen, Hans E Bøtker, Henrik Vase, Christian D Peters, Jesper N Bech, Niels H Buus, Anne P Schroeder, Hans Rickers, Klavs W Hansen, Per L Poulsen, Anne Kaltoft, Kent L Christensen
BACKGROUND: Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH). METHODS: A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized to RDN or SHAM. RDN was performed with the unipolar Medtronic Flex catheter...
October 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29033504/procedural-characteristics-and-outcomes-of-transcatheter-aortic-valve-implantation-a-single-center-experience-of-the-first-100-inoperable-or-high-surgical-risk-patients-with-severe-aortic-stenosis
#4
Ying-Hwa Chen, Hsiao-Huang Chang, Po-Lin Chen, Zen-Chung Weng, I-Ming Chen, Hsin-Bang Leu, Chun-Yang Huang, Su-Man Lin, Mei-Han Wu
BACKGROUND: This is the first study of a Taiwanese population reporting transcatheter aortic valve implantation (TAVI) outcomes of the first 100 cases from a single center offering two different transcatheter heart valve technologies via six types of approaches. We herein report the 30-day and one-year outcomes in our first 100 TAVI patients at Taipei Veterans General Hospital. METHODS: From May 2010 to April 2016, 100 consecutive patients with severe aortic stenosis (AS) who were considered unsuitable or at high risk for surgical aortic valve replacement underwent TAVI...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29031219/long-term-correlation-of-subthalamic-beta-band-activity-with-motor-impairment-in-patients-with-parkinson-s-disease
#5
Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider, Peter Brown, Andrea A Kühn
OBJECTIVES: To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS: We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest...
September 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29029949/mitral-valve-replacement-using-carpentier-edwards-pericardial-bioprosthesis-in-patients-with-rheumatic-heart-disease-aged-below-40-years-17-year-results
#6
Ujjwal Kumar Chowdhury, Adil Rizvi, Rajeev Narang, Sandeep Seth, Mani Kalaivani, Suruchi Hasija, Lakshmi Kumari
BACKGROUND: This study was designed to evaluate patients aged less than 40 years implanted with tissue heart valves with respect to survival, thromboembolism, structural degeneration and quality of life. METHODS: Between January, 2000 and December, 2016, 132 patients (51 males) with rheumatic heart disease underwent mitral valve replacement using Carpentier-Edwards, perimount, pericardial bioprostheses. The patients' ages ranged between 12 and 39 years (mean±SD 30...
August 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29024404/removal-of-sacral-nerve-stimulation-devices-for-magnetic-resonance-imaging-what-happens-next
#7
Jessica C Lloyd, Bradley C Gill, Javier Pizarro-Berdichevsky, Howard B Goldman
INTRODUCTION: Sacral neuromodulation (SNM) devices (Medtronic, Minneapolis, MN, USA) are not approved to undergo magnetic resonance imaging (MRI) of sites other than the head. When MRIs are required, devices are often removed prior to imaging. We reviewed the prevalence of device removal for MRI at a large academic institution and the subsequent clinical course of these patients. METHODS: A retrospective review of all SNM explants from 2009-2015 was performed. Cases explanted for MRI were analyzed to collect demographics, clinical characteristics, and postremoval management...
October 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29021928/bravo%C3%A2-capsule-aspiration-a-rare-case-report
#8
Abdul Haseeb, Noman Lateef, Muhammad Bilal, Kumar Gaurav, Jason Prudom, Ali Musani
Bravo® capsule (BC) (Medtronic, Minneapolis, MN) endoscopy is a reliable, viable, and well-tolerated diagnostic modality for resistant gastroesophageal reflux disease (GERD). Common complications of the procedure include early dislodgment, poor transmission, and premature removal due to intractable pain, while aspiration of the capsule is exceedingly rare. This paper reports a case of BC aspiration in a 52-year-old female who presented after being ventilated when her oxygen saturation dropped. The initial chest radiograph revealed that the BC was in the right main bronchus; the site was further elaborated by flexible endoscopy and the capsule was found to be in the right lower lobe bronchus distal to the bronchus intermedius...
August 9, 2017: Curēus
https://www.readbyqxmd.com/read/29017465/frequency-of-arrhythmia-symptoms-and-acceptability-of-implantable-cardiac-monitors-in-hemodialysis-patients
#9
Naya El Hage, Bernard G Jaar, Alan Cheng, Chloe Knight, Elena Blasco-Colmenares, Luis Gimenez, Eliseo Guallar, Tariq Shafi
BACKGROUND: Arrhythmia-related complications and sudden death are common in dialysis patients. However, routine cardiac monitoring has so far not been feasible. Miniaturization of implantable cardiac monitors offers a new paradigm for detection and management of arrhythmias in dialysis patients. The goal of our study was to determine the frequency of arrhythmia-related symptoms in hemodialysis patients and to assess their willingness to undergo implantation of a cardiac monitor. METHODS: We conducted a survey of in-center hemodialysis patients at a hemodialysis clinic in Baltimore, Maryland...
October 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29016777/long-term-impact-of-intrathoracic-impedance-findings-on-survival-and-heart-failure-hospitalizations-after-cardiac-resynchronization-therapy-in-icd-registry-patients
#10
Jason R Brown, Alvaro Alonso, Eduardo N Warman, Kenneth C Bilchick
Aims: To determine adjusted associations among OptiVol® threshold crossings, long-term survival, and hospitalizations among heart failure (HF) patients with Medicare coverage in the United States. Methods and results: A cohort with OptiVol®-enabled cardiac resynchronization therapy defibrillators (CRT-D) devices from the Implantable Cardioverter Defibrillator Registry was linked to both Medicare claims/summary data and Medtronic's CareLink® Network data. An extended multivariable Cox model was used to analyse associations among OptiVol® threshold crossings (treated as time-dependent covariates), mortality, and HF-related hospitalizations (HFH)...
August 25, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016753/clinical-impact-safety-and-accuracy-of-the-remotely-monitored-implantable-loop-recorder-medtronic-reveal-linqtm
#11
Massimiliano Maines, Alessandro Zorzi, Giancarlo Tomasi, Carlo Angheben, Domenico Catanzariti, Lucio Piffer, Maurizio Del Greco
Aims: Implantable loop recorders (ILR) are indicated in a variety of clinical situations when extended cardiac rhythm monitoring is needed. We aimed to assess the clinical impact, safety, and accuracy of the new Medtronic Reveal LINQTM ILR that can be inserted outside the electrophysiology (EP) laboratory and remotely monitored. Methods and results: All 154 consecutive patients (100 males, 63 ± 15 year-old) who received the Reveal LINQTM ILR during the period July 2014-June 2016 were enrolled...
July 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28992720/accuracy-and-time-delay-of-glucose-measurements-of-continuous-glucose-monitoring-and-bedside-artificial-pancreas-during-hyperglycemic-and-euglycemic-hyperinsulinemic-glucose-clamp-study
#12
Akio Kuroda, Satoshi Taniguchi, Yuko Akehi, Hiroyasu Mori, Motoyuki Tamaki, Reiko Suzuki, Yinhua Otsuka, Munehide Matsuhisa
BACKGROUND: Glucose values of continuous glucose monitoring (CGM) have time delays compared with plasma glucose (PG) values. The artificial pancreas (STG-55, Nikkiso, Japan) (AP), which measures venous blood glucose directly, also has a time delay because of the long tubing lines from sampling vessel to the glucose sensor. We investigate accuracy and time delay of CGM and AP in comparison with PG values during 2-step glucose clamp study. METHODS: Seven patients with type 2 diabetes and 2 healthy volunteers were included in this study...
October 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28988450/feasibility-of-coronary-angiography-and-percutaneous-coronary-intervention-after-transcatheter-aortic-valve-replacement-using-a-medtronic%C3%A2-self-expandable-bioprosthetic-valve
#13
Wah Wah Htun, Cindy Grines, Theodore Schreiber
BACKGROUND AND OBJECTIVE: With aging, the progression of atherosclerosis in the coronary arteries is expected. The Medtronic™ self-expandable aortic bioprosthetic valve is deployed in the supra-annular position, and it has been challenging to selectively engage coronary arteries post-transcatheter aortic valve replacement (TAVR) even though there are diamond-shaped spaces in the mesh frame within the valve. Given the scarcity of data, we analyzed angiographic and clinical data from all patients requiring coronary angiography (CA) or intervention post-TAVR...
October 8, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28987854/contact-aspiration-with-the-new-arc%C3%A2-catheter-for-thrombectomy-of-acute-ischemic-stroke-a-single-center-results
#14
Benjamin Gory, Francis Turjman
BACKGROUND/OBJECTIVE: Contact aspiration has gained growing acceptance in the endovascular stroke therapy. The safety and efficacy data of the novel ARC™ catheter (Medtronic, Irvine, CA) used for intracranial thrombectomy was poorly evaluated. We reported our preliminary results with the ARC™ with regard to angiographic reperfusion, duration of thrombectomy, safety, and clinical outcome at 90 days. METHODS: In a single center series including 20 large-vessel occlusion stroke patients prospectively collected, we retrospectively evaluated the safety and efficacy profiles of the ARC™ intracranial catheter for first-line contact aspiration...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28982836/randomised-clinical-trial-of-cryoballoon-versus-irrigated-radio-frequency-catheter-ablation-for-atrial-fibrillation-the-effect-of-double-short-versus-standard-exposure-cryoablation-duration-during-pulmonary-vein-isolation-circa-dose-methods-and-rationale
#15
Jason G Andrade, Marc W Deyell, Mariano Badra, Jean Champagne, Marc Dubuc, Peter Leong-Sit, Laurent Macle, Paul Novak, Jean-Francois Roux, John Sapp, Anthony Tang, Atul Verma, George A Wells, Paul Khairy
INTRODUCTION: Pulmonary vein isolation (PVI) is an effective therapy for paroxysmal atrial fibrillation (AF), but it has limitations. The two most significant recent advances have centred on the integration of real-time quantitative assessment of catheter contact force into focal radio frequency (RF) ablation catheters and the development of dedicated ablation tools capable of achieving PVI with a single ablation lesion (Arctic Front cryoballoon, Medtronic, Minneapolis, MN, USA). Although each of these holds promise for improving the clinical success of catheter ablation of AF, there has not been a rigorous comparison of these advanced ablation technologies...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28982135/changes-in-aortic-pulse-wave-velocity-of-four-thoracic-aortic-stent-grafts-in-an-ex-vivo-porcine-model
#16
Hector W L de Beaufort, Margherita Coda, Michele Conti, Theodorus M J van Bakel, Foeke J H Nauta, Ettore Lanzarone, Frans L Moll, Joost A van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
OBJECTIVES: Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. METHODS: Twenty porcine thoracic aortas were connected to a pulsatile mock loop system. Intraluminal pressure was recorded at two sites in order to measure pulse wave velocity (PWV) for each aorta: before stent graft deployment (t1); after deployment of a 100-mm long stent graft (t2); and after distal extension through deployment of a second 100-mm long stent graft (t3)...
2017: PloS One
https://www.readbyqxmd.com/read/28976785/type-1-diabetes-and-long-term-continuous-subcutaneous-insulin-infusion-therapy-a-10-year-experience-from-macedonia
#17
Goran Petrovski, Marija Zivkovic, Slavica Subeska Stratrova, Biljana Jovanovska Todorova
BACKGROUND: Subcutaneous insulin infusion (CSII) therapy is a challenge for both patients and healthcare providers. The long-term CSII use is scarce. The aim of this study is to describe the impact of CSII therapy for 10 years of use at our center. METHODS: This single-center retrospective study includes 162 type 1 diabetes patients using CSII for >3 years during October 2004 until October 2014. Data were collected through the electronic medical record system, cross-sectional analysis (telephone, e-mail, or social media), and CSII reports generated by Carelink Therapy Management Software (Medtronic, Northridge, CA)...
October 4, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28975677/sacral-neuromodulation-standardized-electrode-placement-technique
#18
Klaus E Matzel, Emmanuel Chartier-Kastler, Charles H Knowles, Paul A Lehur, Arantxa Muñoz-Duyos, Carlo Ratto, Mona B Rydningen, Michael Sørensen, Philip van Kerrebroeck, Stefan de Wachter
INTRODUCTION: Sacral neuromodulation (SNM) (sacral nerve stimulation SNS) has become an established therapy for functional disorders of the pelvic organs. Despite its overall success, the therapy fails in a proportion of patients. This may be partially due to inadequate electrode placement with suboptimal coupling of the electrode and nerve. Based on these assumptions the technique of sacral spinal neuromodulation has been redefined. All descriptions relate to the only currently available system licensed for all pelvic indications (Medtronic Interstim(®) )...
October 4, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28974132/comparison-of-activated-clotting-times-measured-using-the-hemochron-jr-signature-and-medtronic-act-plus-during-cardiopulmonary-bypass-with-acute-normovolemic-haemodilution
#19
Jung Min Lee, Eun Young Park, Kyung Mi Kim, Jong Chan Won, Tack Koon Jung, Soo Kyung Lee
Objective This study compared the activated clotting time (ACT) measured using the Hemochron Jr. Signature (HACT) with the ACT measured using the Medtronic ACT Plus (MACT) during cardiopulmonary bypass (CPB) with acute normovolemic haemodilution (ANH) in patients undergoing cardiac surgery. Methods The ACT was checked at baseline with both devices after inducing anaesthesia, and 400 to 800 mL of whole blood was withdrawn to induce moderate ANH. Before initiating CPB, a 300-IU/kg bolus dose of heparin was administered to maintain the HACT at >400 s; protamine was later given to reverse the anticoagulation...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28969313/randomized-trial-of-near-infrared-spectroscopy-for-personalized-optimization-of-cerebral-tissue-oxygenation-during-cardiac-surgery
#20
C A Rogers, S Stoica, L Ellis, E A Stokes, S Wordsworth, L Dabner, G Clayton, R Downes, E Nicholson, S Bennett, G D Angelini, B C Reeves, G J Murphy
Background: We assessed whether a near-infrared spectroscopy (NIRS)-based algorithm for the personalized optimization of cerebral oxygenation during cardiopulmonary bypass combined with a restrictive red cell transfusion threshold would reduce perioperative injury to the brain, heart, and kidneys. Methods: In a randomized controlled trial, participants in three UK centres were randomized with concealed allocation to a NIRS (INVOS 5100; Medtronic Inc., Minneapolis, MN, USA)-based 'patient-specific' algorithm that included a restrictive red cell transfusion threshold (haematocrit 18%) or to a 'generic' non-NIRS-based algorithm (standard care)...
September 1, 2017: British Journal of Anaesthesia
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