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https://www.readbyqxmd.com/read/28103516/molecularly-imprinted-polymers-for-sample-preparation-and-biosensing-in-food-analysis-progress-and-perspectives
#1
REVIEW
Jon Ashley, Mohammad-Ali Shahbazi, Krishna Kant, Vinayaka Aaydha Chidambara, Anders Wolff, Dang Duong Bang, Yi Sun
Molecularly imprinted polymers (MIPs) are biomimetics which can selectively bind to analytes of interest. One of the most interesting areas where MIPs have shown the biggest potential is food analysis. MIPs have found use as sorbents in sample preparation attributed to the high selectivity and high loading capacity. MIPs have been intensively employed in classical solid-phase extraction and solid-phase microextraction. More recently, MIPs have been combined with magnetic bead extraction, which greatly simplifies sample handling procedures...
January 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28103450/paper-based-analytical-devices-for-clinical-diagnosis-recent-advances-in-the-fabrication-techniques-and-sensing-mechanisms
#2
Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians...
January 19, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28096941/transport-of-biomolecules-to-binding-partners-displayed-on-the-surface-of-microbeads-arrayed-in-traps-in-a-microfluidic-cell
#3
Xiaoxiao Chen, Thomas F Leary, Charles Maldarelli
Arrays of probe molecules integrated into a microfluidic cell are utilized as analytical tools to screen the binding interactions of the displayed probes against a target molecule. These assay platforms are useful in enzyme or antibody discovery, clinical diagnostics, and biosensing, as their ultraminiaturized design allows for high sensitivity and reduced consumption of reagents and target. We study here a platform in which the probes are first grafted to microbeads which are then arrayed in the microfluidic cell by capture in a trapping course...
January 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28095700/nanohybrids-consisting-of-magnetic-nanoparticles-and-gold-nanoclusters-as-effective-peroxidase-mimics-and-their-application-for-colorimetric-detection-of-glucose
#4
Seongyeon Cho, Ho Yun Shin, Moon Il Kim
Although protein-stabilized gold nanoclusters (AuNCs) have gathered recent attention as biocompatible peroxidase mimics, their practical utility has been critically limited by the low catalytic activity. Here, the authors have developed a nanohybrid material to significantly enhance the catalytic activity of AuNCs by combining them with other inorganic enzyme mimetics, Fe3O4 magnetic nanoparticles (MNPs), through electrostatic attraction. Owing to the synergistic effect by incorporating AuNCs and MNPs, the constructed nanohybrids yielded highly enhanced catalytic activity and enabled rapid catalytic oxidation of 3,3',5,5'-tetramethylbenzidine substrate to produce a blue-colored solution in proportional to the amount of H2O2...
January 17, 2017: Biointerphases
https://www.readbyqxmd.com/read/28089700/new-synthetic-route-to-ethynyl-dutp-a-means-to-avoid-formation-of-acetyl-and-chloro-vinyl-base-modified-triphosphates-that-could-poison-selex-experiments
#5
Pascal Röthlisberger, Fabienne Levi-Acobas, Marcel Hollenstein
5-Ethynyl-2'-deoxyuridine is a common base-modified nucleoside analogue that has served in various applications including selection experiments for potent aptamers and in biosensing. The synthesis of the corresponding triphosphates involves a mild acidic deprotection step. Herein, we show that this deprotection leads to the formation of other nucleoside analogs which are easily converted to triphosphates. The modified nucleoside triphosphates are excellent substrates for numerous DNA polymerases under both primer extension and PCR conditions and could thus poison selection experiments by blocking sites that need to be further modified...
January 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28088448/fast-formation-of-low-defect-density-tethered-bilayers-by-fusion-of-multilamellar-vesicles
#6
Tadas Ragaliauskas, Mindaugas Mickevicius, Bozena Rakovska, Tadas Penkauskas, David J Vanderah, Frank Heinrich, Gintaras Valincius
A facile and reproducible preparation of surface-supported lipid bilayers is essential for fundamental membrane research and biotechnological applications. We demonstrate that multilamellar vesicles fuse to molecular-anchor-grafted surfaces yielding low-defect-density, tethered bilayer membranes. Continuous bilayers are formed within 10min, while the electrically insulating bilayers with <0.1μm(-2) defect density can be accomplished within 60min. Surface plasmon resonance spectroscopy indicates that an amount of lipid material transferred from vesicles to a surface is inversely proportional to the density of an anchor, while the total amount of lipid that includes tethered and transferred lipid remains constant within 5% standard error...
January 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28078419/nanostructured-nio-based-reagentless-biosensor-for-total-cholesterol-and-low-density-lipoprotein-detection
#7
Gurpreet Kaur, Monika Tomar, Vinay Gupta
Nanostructured nickel oxide (NiO) thin film has been explored as a matrix to develop a reagentless biosensor for free and total cholesterol as well as low density lipoprotein (LDL) detection. The redox property of the matrix has been exploited to enhance the electron transfer between the enzyme and the electrode as well as to eliminate the toxic mediator in solution. X-ray diffraction, scanning electron microscopy, atomic force microscopy, and Fourier transform infrared spectroscopy were carried out to characterize the NiO thin film...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28075594/high-curvature-nanostructuring-enhances-probe-display-for-biomolecular-detection
#8
Phil De Luna, Sahar Mahshid, Jagotamoy Das, Binquan Luan, Edward H Sargent, Shana O Kelley, Ruhong Zhou
High-curvature electrodes facilitate rapid and sensitive detection of a broad class of molecular analytes. These sensors have reached detection limits not attained using bulk macroscale materials. It has been proposed that immobilized DNA probes are displayed at a high deflection angle on the sensor surface, allowing greater accessibility and more efficient hybridization. Here we report the first use of all-atom molecular dynamics simulations coupled with electrochemical experiments to explore the dynamics of ssDNA immobilized on high-curvature vs...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28074385/use-of-a-cd-laser-pickup-head-to-fabricate-microelectrodes-in-polymethylmethacrylate-substrates-for-biosensing-applications
#9
Jehú López-Aparicio, Mathieu Hautefeuille, Sara Herrera-Domínguez, Adriana Razo-de-León, Mariel Cano-Jorge, Ixchetl Rojas-Benito, Mariana Centeno-Sierra, Tatiana Fiordelisio-Coll, Catalina Elizabeth Stern-Forgach
In this work, we report a simple fabrication method for microelectrodes on a polymethylmethacrylate substrate, using a low-cost laser platform based on a CD-DVD unit for direct rapid-prototyping. We used this laser microfabrication technique to etch any desired design on polymethylmethacrylate substrates to produce microchannels with controlled geometry, with a highly repeatable micron-scale resolution. Those shallow microchannels were then filled with a conductive paste of material of our choice that was converted into microelectrodes of desired shapes and geometries after drying...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28072546/three-dimensional-integration-of-black-phosphorus-photodetector-with-silicon-photonics-and-nanoplasmonics
#10
Che Chen, Nathan Youngblood, Ruoming Peng, Daehan Yoo, Daniel A Mohr, Timothy W Johnson, Sang-Hyun Oh, Mo Li
We demonstrate the integration of a black phosphorus photodetector in a hybrid, three-dimensional architecture of silicon photonics and metallic nanoplasmonics structures. This integration approach combines the advantages of the low propagation loss of silicon waveguides, high-field confinement of a plasmonic nanogap, and the narrow bandgap of black phosphorus to achieve high responsivity for detection of telecom-band, near-infrared light. Benefiting from an ultrashort channel (∼60 nm) and near-field enhancement enabled by the nanogap structure, the photodetector shows an intrinsic responsivity as high as 10 A/W afforded by internal gain mechanisms, and a 3 dB roll-off frequency of 150 MHz...
January 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28069507/a-highly-versatile-adaptor-protein-for-the-tethering-of-growth-factors-to-gelatin-based-biomaterials
#11
Cyril Addi, Frédéric Murschel, Benoît Liberelle, Nesrine Riahi, Gregory De Crescenzo
: In the field of tissue engineering, the tethering of growth factors to tissue scaffolds in an oriented manner can enhance their activity and increase their half-life. We chose to investigate the capture of the basic Fibroblast Growth Factor (bFGF) and the Epidermal Growth Factor (EGF) on a gelatin layer, as a model for the functionalization of collagen-based biomaterials. Our strategy relies on the use of two high affinity interactions, that is, the one between two distinct coil peptides as well as the one occurring between a collagen-binding domain (CBD) and gelatin...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28068766/membrane-adhesion-through-bridging-by-multimeric-ligands
#12
Omar Alexander Amjad, Bortolo Matteo Mognetti, Pietro Cicuta, Lorenzo Di Michele
Ligand/receptor multivalent interactions have been exploited to drive the self-assembly of nanoparticles, hard colloids, and more recently compliant units including emulsion droplets and lipid vesicles. In deformable liposomes, the formation of links between two membranes produces morphological changes depending on the amount of ligands in the environment. Here we study a proof-of-concept biosensing system in which single lipid vesicles adhere to a flat supported lipid bilayer, both decorated with membrane-anchored biotinylated receptors...
January 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28068104/unraveling-interactions-between-ionic-liquids-and-phospholipid-vesicles-using-nanoplasmonic-sensing
#13
Joanna Witos, Giacomo Russo, Suvi-Katriina Ruokonen, Susanne K Wiedmer
Owing to their unique properties and unlimited structural combinations, the ubiquitous use of ionic liquids (ILs) is steadily increasing. The objective of the present work is to shed light onto the effects of amidinium- and phosphonium-based ILs on phospholipid vesicles using a nanoplasmonic sensing measurement technique. A new and relatively simple method was developed for the immobilization of large unilamellar vesicles on two different hydrophilic surfaces composed of titanium dioxide and silicon nitride nanolayers...
January 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28067433/plasmonic-imaging-of-the-interfacial-potential-distribution-on-bipolar-electrodes
#14
Meisam Hasheminejad, Yimin Fang, Meng Li, Yingyan Jiang, Wei Wang, Hong-Yuan Chen
Bipolar electrochemistry is based on the gradient distribution of free-electron density along an electrically isolated electrode, which causes a positive electrode potential at one end and a negative potential at the other, allowing for wide applications in analytical chemistry and materials science. To take full advantage of its wireless and high-throughput features, various types of optical probes, such as pH indicators and fluorescence and electrochemiluminescence reagents, have often been used to indirectly monitor the interfacial electron transfer through chromogenic or fluorogenic reactions...
January 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28062235/new-approach-to-biosensing-of-co-enzyme-nicotinamide-adenine-dinucleotide-nadh-by-incorporation-of-neutral-red-in-aluminum-doped-nanostructured-zno-thin-films
#15
V T Fidal, T S Chandra
Biosensing of NADH on bare electrodes has drawbacks such as high over-potential and poisoning during the oxidation reaction. To overcome this challenge a different approach has been undertaken by incorporating neutral red (NR) in Al doped ZnO (AZO) thin films using one-pot chemical bath deposition (CBD). The surface morphology of the films was hexagonal nanorods along the c-axis, perpendicular to the substrate. The thickness of the thin films were ranging from 400 to 3000nm varying dependent on time of deposition (30 to 150min)...
January 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28055826/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#16
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
December 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28054656/fabrication-of-enzyme-based-coatings-on-intact-multi-walled-carbon-nanotubes-as-highly-effective-electrodes-in-biofuel-cells
#17
Byoung Chan Kim, Inseon Lee, Seok-Joon Kwon, Youngho Wee, Ki Young Kwon, Chulmin Jeon, Hyo Jin An, Hee-Tae Jung, Su Ha, Jonathan S Dordick, Jungbae Kim
CNTs need to be dispersed in aqueous solution for their successful use, and most methods to disperse CNTs rely on tedious and time-consuming acid-based oxidation. Here, we report the simple dispersion of intact multi-walled carbon nanotubes (CNTs) by adding them directly into an aqueous solution of glucose oxidase (GOx), resulting in simultaneous CNT dispersion and facile enzyme immobilization through sequential enzyme adsorption, precipitation, and crosslinking (EAPC). The EAPC achieved high enzyme loading and stability because of crosslinked enzyme coatings on intact CNTs, while obviating the chemical pretreatment that can seriously damage the electron conductivity of CNTs...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050875/infrared-plasmonic-refractive-index-sensor-with-ultra-high-figure-of-merit-based-on-the-optimized-all-metal-grating
#18
Ruifang Li, Dong Wu, Yumin Liu, Li Yu, Zhongyuan Yu, Han Ye
A perfect ultra-narrow band infrared metamaterial absorber based on the all-metal-grating structure is proposed. The absorber presents a perfect absorption efficiency of over 98% with an ultra-narrow bandwidth of 0.66 nm at normal incidence. This high efficient absorption is contributed to the surface plasmon resonance. Moreover, the surface plasmon resonance-induced strong surface electric field enhancement is favorable for application in biosensing system. When operated as a plasmonic refractive index sensor, the ultra-narrow band absorber has a wavelength sensitivity 2400 nm/RIU and an ultra-high figure of merit 3640, which are much better than those of most reported similar plasmonic sensors...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28045501/the-advancement-of-the-emerging-field-of-rna-nanotechnology
#19
Daniel Jasinski, Farzin Haque, Daniel W Binzel, Peixuan Guo
The field of RNA nanotechnology has advanced rapidly during the last decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popularity of RNA nanoparticles is due to a number of factors: (1) Removing the concern of RNA degradation in vitro and in vivo by introducing chemical modification into nucleotides without significant alteration of the RNA property in folding and self-assembly; (2) Confirming the concept that RNA displays very high thermodynamic stability and is suitable for in vivo trafficking and other applications; (3) Obtaining the knowledge to tune the immunogenic properties of synthetic RNA constructs for in vivo applications; (4) Increased understanding of the 4D structure and intermolecular interaction of RNA molecules; (5) Developing methods to control shape, size and stoichiometry of RNA nanoparticles; (6) Increasing knowledge of unique regulation and processing functions of RNA in cells; (7) Decreasing cost of RNA production by biological and chemical synthesis; and (8) Proving the concept that RNA is a safe and specific therapeutic modality for cancer and other diseases with little or no accumulation in vital organs...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28044400/co2-assisted-fabrication-of-two-dimensional-amorphous-molybdenum-oxide-nanosheets-for-enhanced-plasmon-resonances
#20
Wei Liu, Qun Xu, Weili Cui, Chuanhui Zhu, Yuhang Qi
As a remarkable class of plasmonic materials, two dimensional (2D) semiconductor compounds have attracted attention owing to their controlled manipulation of plasmon resonances in the visible light spectrum, which outperforms conventional noble metals. However, tuning of plasmonic resonances for 2D semiconductors remains challenging. Herein, we design a novel method to obtain amorphous molybdenum oxide (MoO3 ) nanosheets, in which it combines the oxidation of MoS2 and subsequent supercritical CO2 -treatment, which is a crucial step for the achievement of amorphous structure of MoO3 ...
January 3, 2017: Angewandte Chemie
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