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Hui Wang, Qianwang Chen, Shuiqin Zhou
Nanosized crosslinked polymer networks, named as nanogels, are playing an increasingly important role in a diverse range of applications by virtue of their porous structures, large surface area, good biocompatibility and responsiveness to internal and/or external chemico-physical stimuli. Recently, a variety of carbon nanomaterials, such as carbon quantum dots, graphene/graphene oxide nanosheets, fullerenes, carbon nanotubes, and nanodiamonds, have been embedded into responsive polymer nanogels, in order to integrate the unique electro-optical properties of carbon nanomaterials with the merits of nanogels into a single hybrid nanogel system for improvement of their applications in nanomedicine...
April 18, 2018: Chemical Society Reviews
Yan-Mei Lei, Rui-Xin Wen, Jia Zhou, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
In this work, with the use of Ag (I) ion as a robust coreaction accelerator toward enhancement of 3,4,9,10-perylenetetracarboxylic acid/peroxydisulfate (PTCA/S2O82-) system, a highly sensitive solid-state electrochemiluminescence (ECL) biosensing platform was successfully designed for mercury ion (Hg2+) detection. Specifically, a long guanine-rich (C-rich) double-stranded DNA (dsDNA) was generated by the target Hg2+-controlled DNA machine, which could embed the Ag (I) ion for ECL signal amplification of PTCA/S2O82- system...
April 18, 2018: Analytical Chemistry
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
Yanpeng Li, Hui Ma, Lin Gan, Andong Gong, Haibin Zhang, Deming Liu, Qizhen Sun
Escherichia coli (E.coli) bacteria have been found to be responsible for various health outbreaks caused by contaminated food and water. Accurate and rapid test of E.coli is thus crucial for protecting the public health. A fast-response, label-free bacteriophage-based detection of E.coli using multimode microfiber probe is proposed and demonstrated in this paper. Due to the abrupt taper and subwavelength diameter, different modes are excited and guided in the microfiber as evanescent field that can interact with surrounding E...
April 17, 2018: Journal of Biophotonics
Yanxia Chen, Xuehong Min, Xiqi Zhang, Feilong Zhang, Simeng Lu, Li-Ping Xu, Xiaoding Lou, Fan Xia, Xueji Zhang, Shutao Wang
Superwettable microchips with superhydrophilic microwells on superhydrophobic substrate have attracted increasing attention in fluorescence-based biological and medical diagnostics. However, traditional fluorophores often suffer from the aggregation-caused quenching (ACQ) problem at high concentration or in aggregated state. Here, we developed an AIE-based superwettable microchip by combining the evaporation-induced enrichment of superwettable microchips and the aggregation-induced emission of AIEgens together into one chip...
April 7, 2018: Biosensors & Bioelectronics
Dong Wang, Qian Liu, Di Wu, Binfeng He, Jin Li, Chengde Mao, Guansong Wang, Hang Qian
Programmable DNA nanostructure self-assembly offer great potentials in nanomedicine, drug delivery, biosensing and bioimaging. However, the intrinsically negative-charged DNA backbones, the instability of DNA nanostructures in physiological settings pose serious challenges to their practical applications. To overcome this challenge, a strategy that combines the magnesium-free DNA self-assembly and functionalization is proposed in this study. We hypothesize that naturally abundant spermidine may not only mediate the self-assembly of DNA nanostructures, but also shield them from harsh physiological environments...
April 13, 2018: ACS Applied Materials & Interfaces
Y Rong, A V Padron, K J Hagerty, N Nelson, S Chi, N O Keyhani, J Katz, S P A Datta, C Gomes, E S McLamore
Impedimetric biosensors for measuring small molecules based on weak/transient interactions between bioreceptors and target analytes are a challenge for detection electronics, particularly in field studies or in the analysis of complex matrices. Protein-ligand binding sensors have enormous potential for biosensing, but achieving accuracy in complex solutions is a major challenge. There is a need for simple post hoc analytical tools that are not computationally expensive, yet provide near real time feedback on data derived from impedance spectra...
April 9, 2018: Analyst
Xiaoxia Mao, Guifang Chen, Zihan Wang, Yuanguang Zhang, Xiaoli Zhu, Genxi Li
Hydrogels are of great interest in the field of biosensing for their good biocompatibility, plasticity, and capability of providing 3D scaffolds. Nevertheless, the application of hydrogels has not been linked with broad surface biosensing systems yet. To overcome the limitations, here for the first time, surface-immobilized pure DNA hydrogels were synthesized using a surficial primer-induced strategy and adopted for biosensing applications. The DNA hydrogel 3D scaffold is successfully constructed on a transparent ITO electrode, which facilitates both colourimetric and electrochemical measurements...
January 28, 2018: Chemical Science
Pascal Röthlisberger, Marcel Hollenstein
Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution method coined SELEX (Systematic Evolution of Ligands by EXponential enrichment). Compared to their proteinaceous counterparts, aptamers offer a number of advantages including a low immunogenicity, a relative ease of large-scale synthesis at affordable costs with little or no batch-to-batch variation, physical stability, and facile chemical modification...
April 4, 2018: Advanced Drug Delivery Reviews
Sergey A Pidenko, Natalia A Burmistrova, Andrey A Shuvalov, Anastasiya A Chibrova, Yulia S Skibina, Irina Y Goryacheva
This review covers the current state of the art of luminescent biosensors based on various types of microstructured optical fiber. The unique optical and structural properties of this type of optical fiber make them one of the most promising integrated platforms for bioassays. The individual sections of this review are devoted to a) classification of microstructured optical fibers, b) microstructured optical fiber materials, c) aspects of biosensing based on the biomolecules incorporated into the microstructured optical fibers, and d) development of models for prediction of the efficiency of luminescent signal processing...
August 17, 2018: Analytica Chimica Acta
Samiul Alim, A K M Kafi, Rajan Jose, Mashitah M Yusoff, Jaya Vejayan
A novel third generation H2 O2 biosensor is fabricated using multiporous SnO2 nanofiber/carbon nanotubes (CNTs) composite as a matrix for the immobilization of redox protein onto glassy carbon electrode. The multiporous nanofiber (MPNFs) of SnO2 is synthesized by electrospinning technique from the tin precursor. This nanofiber shows high surface area and good electrical conductivity. The SnO2 nanofiber/CNT composite increases the efficiency of biomolecule loading due to its high surface area. The morphology of the nanofiber has been evaluated by scanning electron microscopy (SEM)...
April 3, 2018: International Journal of Biological Macromolecules
Haley Shelley, R Jayachandra Babu
Cyclodextrins (CDs) are cyclic oligosaccharides with unique hydrophobic interior surface. Three parent CDs, α-CD, β-CD, and γ-CD, are further chemically modified primarily to make them suited for parenteral administration and these are used for many pharmaceutical applications. CDs offer distinctive advantages due to their unique ability to form inclusion complexes with a variety of organic and inorganic lipophilic molecules. This attribute is promising for a wide range of fields such as drug delivery, cancer therapy, gene delivery, and biosensing...
April 3, 2018: Journal of Pharmaceutical Sciences
Haneul Yoo, Dong Jun Lee, Daesan Kim, Junun Park, Xing Chen, Seunghun Hong
We report a magnetically-focusing biochip structure enabling a single layered magnetic trap-and-release cycle for biosensors with an improved detection speed and selectivity. Here, magnetic beads functionalized with specific receptor molecules were utilized to trap target molecules in a solution and transport actively to and away from the sensor surfaces to enhance the detection speed and reduce the non-specific bindings, respectively. Using our method, we demonstrated the high speed detection of IL-13 antigens with the improved detection speed by more than an order of magnitude...
April 6, 2018: Nanotechnology
Yonggang Ke, Carlos Castro, Jong Hyun Choi
Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson-Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and programmability. The nanostructures could be either static, with well-controlled physicochemical properties, or dynamic, with the ability to reconfigure upon external stimuli...
April 4, 2018: Annual Review of Biomedical Engineering
Lidia Nazaret Gómez-Arribas, Elena Benito-Peña, María Del Carmen Hurtado-Sánchez, María Cruz Moreno-Bondi
Food allergy is one of the major health threats for sensitized individuals all over the world and, over the years, the food industry has made significant efforts and investments to offer safe foods for allergic consumers. The analysis of the concentration of food allergen residues in processing equipment, in raw materials or in the final product, provides analytical information that can be used for risk assessment as well as to ensure that food-allergic consumers get accurate and useful information to make their food choices and purchasing decisions...
April 4, 2018: Sensors
In Soo Ryu, Jieun Kim, Su Yeon Seo, Ju Hwan Yang, Jeong Hwan Oh, Dong Kun Lee, Hyun-Wook Cho, Kyuhong Lee, Seong Shoon Yoon, Joung-Wook Seo, Insop Shim, Eun Sang Choe
Nicotine, a nicotinic acetylcholine receptor agonist, produces the reinforcing effects of tobacco dependence by potentiating dopaminergic and glutamatergic neurotransmission. Non-nicotine alkaloids in tobacco also contribute to dependence by activating the cholinergic system. However, glutamatergic neurotransmission in the dorsal striatum associated with behavioral changes in response to cigarette smoking has not been investigated. In this study, the authors investigated alterations in glutamate levels in the rat dorsal striatum related to behavioral alterations after repeated administration of cigarette smoke condensate (CSC) using the real-time glutamate biosensing and an open-field behavioral assessment...
2018: Frontiers in Behavioral Neuroscience
Abhijit Saha, Trevor G Johnston, Ryan T Shafranek, Cassandra J Goodman, Jesse G Zalatan, Duane W Storti, Mark A Ganter, Alshakim Nelson
Living materials, which are composites of living cells residing in a polymeric matrix, are designed to utilize the innate functionalities of the cells to address a broad range of applications such as fermentation and biosensing. Herein, we demonstrate the additive manufacturing of catalytically active living materials (AMCALM) for continuous fermentation. A multi-stimuli-responsive yeast-laden hydrogel ink-based on F127-dimethacrylate-was developed and printed using a direct-write 3D printer. The reversible stimuli-responsive behaviors of the polymer hydrogel inks to temperature and pressure are critical, as they enabled the facile incorporation of yeast cells and subsequent fabrication of 3D lattice constructs...
April 2, 2018: ACS Applied Materials & Interfaces
Dong-Fang Liao, Chan Cao, Yi-Lun Ying, Yi-Tao Long
An aerolysin nanopore is employed as a sensitive tool for single-molecule analysis of short oligonucleotides (≤10 nucleotides), poly(ethylene glycol) (PEGs), peptides, and proteins. However, the direct analysis of long oligonucleotides with the secondary structure (e.g., G-quadruplex topology) remains a challenge, which impedes the further practical applications of the aerolysin nanopore. Here, a simple and applicable method of aerolysin nanopore is presented to achieve a direct analysis of structured oligonucleotides that are extended to 30 nucleotides long by a cation-regulation mechanism...
March 30, 2018: Small
Qi Liu, Zhilei Ge, Xiuhai Mao, Guobao Zhou, Xiaolei Zuo, Juwen Shen, Jiye Shi, Jiang Li, Lihua Wang, Xiaoqing Chen, Chunhai Fan
Weak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in in-vitro biomimetic systems generally lack the spatiotemporal regulation in vivo. Here we report a framework nucleic acids (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins and inorganic nanoparticles in a stoichiometric manner...
March 30, 2018: Angewandte Chemie
Harshvardhan Modh, Thomas Scheper, Johanna-Gabriela Walter
Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes...
March 30, 2018: Sensors
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