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https://www.readbyqxmd.com/read/29016141/x-ray-and-neutron-reflectivity-study-shows-that-clic1-undergoes-cholesterol-dependent-structural-reorganization-in-lipid-monolayers
#1
Khondker R Hossain, Stephen A Holt, Anton P Le Brun, Heba Al Khamici, Stella M Valenzuela
CLIC1 belongs to the ubiquitous family of chloride intracellular ion channel proteins that are evolutionarily conserved across species. The CLICs are unusual in that they exist mainly as soluble proteins but possess the intriguing property of spontaneous conversion from the soluble to an integral membrane-bound form. This conversion is regulated by the membrane lipid composition, especially by cholesterol, together with external factors such as oxidation and pH. However, the precise physiological mechanism regulating CLIC1 membrane insertion is currently unknown...
October 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28961843/global-patterns-of-care-in-advanced-stage-mycosis-fungoides-sezary-syndrome-a-multicenter-retrospective-follow-up-study-from-the-cutaneous-lymphoma-international-consortium
#2
P Quaglino, M Maule, H M Prince, P Porcu, S Horwitz, M Duvic, R Talpur, M Vermeer, M Bagot, J Guitart, E Papadavid, J A Sanches, E Hodak, M Sugaya, E Berti, P Ortiz-Romero, N Pimpinelli, O Servitje, A Pileri, P L Zinzani, T Estrach, R Knobler, R Stadler, M T Fierro, S Alberti Violetti, I Amitay-Laish, C Antoniou, C Astrua, S Chaganti, F Child, A Combalia, S Fabbro, P Fava, V Grandi, C Jonak, E Martinez-Escala, M Kheterpal, E J Kim, C McCormack, T Miyagaki, D Miyashiro, S Morris, C Muniesa, V Nikolaou, G Ognibene, F Onida, S Osella-Abate, S Porkert, C Postigo-Llorente, C Ram-Wolff, S Ribero, K Rogers, M Sanlorenzo, R Stranzenbach, N Spaccarelli, A Stevens, D Zugna, A H Rook, L J Geskin, R Willemze, S Whittaker, R Hoppe, J Scarisbrick, Y Kim
Background: Advanced-stage mycosis fungoides (MF)/Sézary syndrome (SS) patients are weighted by an unfavorable prognosis and share an unmet clinical need of effective treatments. International guidelines are available detailing treatment options for the different stages but without recommending treatments in any particular order due to lack of comparative trials. The aims of this second CLIC study were to retrospectively analyze the pattern of care worldwide for advanced-stage MF/SS patients, the distribution of treatments according to geographical areas (USA versus non-USA), and whether the heterogeneity of approaches has potential impact on survival...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28943795/higgs-physics-at-the-clic-electron-positron-linear-collider
#3
H Abramowicz, A Abusleme, K Afanaciev, N Alipour Tehrani, C Balázs, Y Benhammou, M Benoit, B Bilki, J-J Blaising, M J Boland, M Boronat, O Borysov, I Božović-Jelisavčić, M Buckland, S Bugiel, P N Burrows, T K Charles, W Daniluk, D Dannheim, R Dasgupta, M Demarteau, M A Díaz Gutierrez, G Eigen, K Elsener, U Felzmann, M Firlej, E Firu, T Fiutowski, J Fuster, M Gabriel, F Gaede, I García, V Ghenescu, J Goldstein, S Green, C Grefe, M Hauschild, C Hawkes, D Hynds, M Idzik, G Kačarević, J Kalinowski, S Kananov, W Klempt, M Kopec, M Krawczyk, B Krupa, M Kucharczyk, S Kulis, T Laštovička, T Lesiak, A Levy, I Levy, L Linssen, S Lukić, A A Maier, V Makarenko, J S Marshall, V J Martin, K Mei, G Milutinović-Dumbelović, J Moroń, A Moszczyński, D Moya, R M Münker, A Münnich, A T Neagu, N Nikiforou, K Nikolopoulos, A Nürnberg, M Pandurović, B Pawlik, E Perez Codina, I Peric, M Petric, F Pitters, S G Poss, T Preda, D Protopopescu, R Rassool, S Redford, J Repond, A Robson, P Roloff, E Ros, O Rosenblat, A Ruiz-Jimeno, A Sailer, D Schlatter, D Schulte, N Shumeiko, E Sicking, F Simon, R Simoniello, P Sopicki, S Stapnes, R Ström, J Strube, K P Świentek, M Szalay, M Tesař, M A Thomson, J Trenado, U I Uggerhøj, N van der Kolk, E van der Kraaij, M Vicente Barreto Pinto, I Vila, M Vogel Gonzalez, M Vos, J Vossebeld, M Watson, N Watson, M A Weber, H Weerts, J D Wells, L Weuste, A Winter, T Wojtoń, L Xia, B Xu, A F Żarnecki, L Zawiejski, I-S Zgura
The Compact Linear Collider (CLIC) is an option for a future [Formula: see text] collider operating at centre-of-mass energies up to [Formula: see text], providing sensitivity to a wide range of new physics phenomena and precision physics measurements at the energy frontier. This paper is the first comprehensive presentation of the Higgs physics reach of CLIC operating at three energy stages: [Formula: see text], 1.4 and [Formula: see text]. The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung ([Formula: see text]) and [Formula: see text]-fusion ([Formula: see text]), resulting in precise measurements of the production cross sections, the Higgs total decay width [Formula: see text], and model-independent determinations of the Higgs couplings...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28886120/chloride-intracellular-channel-proteins-respond-to-heat-stress-in-caenorhabditis-elegans
#4
Jun Liang, Yakov Shaulov, Cathy Savage-Dunn, Stephane Boissinot, Tasmia Hoque
Chloride intracellular channel proteins (CLICs) are multi-functional proteins that are expressed in various cell types and differ in their subcellular location. Two CLIC homologs, EXL-1 (excretory canal abnormal like-1) and EXC-4 (excretory canal abnormal- 4), are encoded in the Caenorhabditis elegans genome, providing an excellent model to study the functional diversification of CLIC proteins. EXC-4 functions in excretory canal formation during normal animal development. However, to date, the physiological function of EXL-1 remains largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28860555/chloride-channels-are-involved-in-the-development-of-atrial-fibrillation-a-transcriptomic-and-proteomic-study
#5
Yi-Yao Jiang, Hai-Tao Hou, Qin Yang, Xiao-Cheng Liu, Guo-Wei He
Electrical and structural remodeling processes are contributors to the self-perpetuating nature of atrial fibrillation (AF). However, their correlation has not been clarified. In this study, human atrial tissues from the patients with rheumatic mitral valve disease in either sinus rhythm or persistent AF were analyzed using a combined transcriptomic and proteomic approach. An up-regulation in chloride intracellular channel (CLIC) 1, 4, 5 and a rise in type IV collagen were revealed. Combined with the results from immunohistochemistry and electron microscope analysis, the distribution of type IV collagen and effects of fibrosis on myocyte membrane indicated the possible interaction between CLIC and type IV collagen, confirmed by protein structure prediction and co-immunoprecipitation...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819106/identification-and-characterization-of-a-bacterial-homolog-of-chloride-intracellular-channel-clic-protein
#6
Shubha Gururaja Rao, Devasena Ponnalagu, Sowmya Sukur, Harkewal Singh, Shridhar Sanghvi, Yixiao Mei, Ding J Jin, Harpreet Singh
Chloride intracellular channels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targeting. In eukaryotes, they are implicated in cell volume regulation, acidification, and cell cycle. CLICs resemble the omega class of Glutathione S-transferases (GST), yet differ from them in their ability to form ion channels. They are ubiquitously found in eukaryotes but no prokaryotic homolog has been characterized. We found that indanyloxyacetic acid-94 (IAA-94), a blocker of CLICs, delays the growth of Escherichia coli...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719601/clic-a-tool-for-expanding-biological-pathways-based-on-co-expression-across-thousands-of-datasets
#7
Yang Li, Alexis A Jourdain, Sarah E Calvo, Jun S Liu, Vamsi K Mootha
In recent years, there has been a huge rise in the number of publicly available transcriptional profiling datasets. These massive compendia comprise billions of measurements and provide a special opportunity to predict the function of unstudied genes based on co-expression to well-studied pathways. Such analyses can be very challenging, however, since biological pathways are modular and may exhibit co-expression only in specific contexts. To overcome these challenges we introduce CLIC, CLustering by Inferred Co-expression...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28466637/on-chip-evaluation-of-dna-methylation-with-electrochemical-combined-bisulfite-restriction-analysis-utilizing-a-carbon-film-containing-a-nanocrystalline-structure
#8
Ryoji Kurita, Hiroyuki Yanagisawa, Tomoyuki Kamata, Dai Kato, Osamu Niwa
This paper reports an on-chip electrochemical assessment of the DNA methylation status in genomic DNA on a conductive nanocarbon film electrode realized with combined bisulfite restriction analysis (COBRA). The film electrode consists of sp(2) and sp(3) hybrid bonds and is fabricated with an unbalanced magnetron (UBM) sputtering method. First, we studied the effect of the sp(2)/sp(3) ratio of the UBM nanocarbon film electrode with p-aminophenol, which is a major electro-active product of the labeling enzyme from p-aminophenol phosphate...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/27980069/multiple-routes-of-endocytic-internalization-of-pdgfr%C3%AE-contribute-to-pdgf-induced-stat3-signaling
#9
Kamil Jastrzębski, Daria Zdżalik-Bielecka, Agnieszka Mamińska, Yannis Kalaidzidis, Carina Hellberg, Marta Miaczynska
Platelet-derived growth factor receptor β (PDGFRβ) is a receptor tyrosine kinase which upon activation by PDGF-BB stimulates cell proliferation, migration and angiogenesis. Ligand binding induces intracellular signaling cascades but also internalization of the receptor, eventually resulting in its lysosomal degradation. However, endocytic trafficking of receptors often modulates their downstream signaling. We previously reported that internalization of PDGFRβ occurs via dynamin-dependent and -independent pathways but their further molecular determinants remained unknown...
February 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/27941637/investigating-sterol-and-redox-regulation-of-the-ion-channel-activity-of-clic1-using-tethered-bilayer-membranes
#10
Heba Al Khamici, Khondher R Hossain, Bruce A Cornell, Stella M Valenzuela
The Chloride Intracellular Ion Channel (CLIC) family consists of six conserved proteins in humans. These are a group of enigmatic proteins, which adopt both a soluble and membrane bound form. CLIC1 was found to be a metamorphic protein, where under specific environmental triggers it adopts more than one stable reversible soluble structural conformation. CLIC1 was found to spontaneously insert into cell membranes and form chloride ion channels. However, factors that control the structural transition of CLIC1 from being an aqueous soluble protein into a membrane bound protein have yet to be adequately described...
December 8, 2016: Membranes
https://www.readbyqxmd.com/read/27852828/emerging-biological-roles-of-cl-intracellular-channel-proteins
#11
REVIEW
Elisabetta Argenzio, Wouter H Moolenaar
Cl(-) intracellular channels (CLICs) are a family of six evolutionary conserved cytosolic proteins that exist in both soluble and membrane-associated forms; however, their functions have long been elusive. Soluble CLICs adopt a glutathione S-transferase (GST)-fold, can induce ion currents in artificial membranes and show oxidoreductase activity in vitro, but there is no convincing evidence of CLICs having such activities in vivo. Recent studies have revealed a role for CLIC proteins in Rho-regulated cortical actin dynamics as well as vesicular trafficking and integrin recycling, the latter of which are under the control of Rab GTPases...
November 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27791132/endocytosis-of-wingless-via-a-dynamin-independent-pathway-is-necessary-for-signaling-in-drosophila-wing-discs
#12
Anupama Hemalatha, Chaitra Prabhakara, Satyajit Mayor
Endocytosis of ligand-receptor complexes regulates signal transduction during development. In particular, clathrin and dynamin-dependent endocytosis has been well studied in the context of patterning of the Drosophila wing disc, wherein apically secreted Wingless (Wg) encounters its receptor, DFrizzled2 (DFz2), resulting in a distinctive dorso-ventral pattern of signaling outputs. Here, we directly track the endocytosis of Wg and DFz2 in the wing disc and demonstrate that Wg is endocytosed from the apical surface devoid of DFz2 via a dynamin-independent CLIC/GEEC pathway, regulated by Arf1, Garz, and class I PI3K...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27783269/anion-channels-of-mitochondria
#13
Devasena Ponnalagu, Harpreet Singh
Mitochondria are the "power house" of a cell continuously generating ATP to ensure its proper functioning. The constant production of ATP via oxidative phosphorylation demands a large electrochemical force that drives protons across the highly selective and low-permeable mitochondrial inner membrane. Besides the conventional role of generating ATP, mitochondria also play an active role in calcium signaling, generation of reactive oxygen species (ROS), stress responses, and regulation of cell-death pathways...
2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27767294/manipulating-and-visualizing-molecular-interactions-in-customized-nanoscale-spaces
#14
Gil Henkin, Daniel Berard, Francis Stabile, Marjan Shayegan, Jason S Leith, Sabrina R Leslie
We present a dynamically adjustable nanofluidic platform for formatting the conformations of and visualizing the interaction kinetics between biomolecules in solution, offering new time resolution and control of the reaction processes. This platform extends convex lens-induced confinement (CLiC), a technique for imaging molecules under confinement, by introducing a system for in situ modification of the chemical environment; this system uses a deep microchannel to diffusively exchange reagents within the nanoscale imaging region, whose height is fixed by a nanopost array...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27765637/the-wing-venation-patterns-to-identify-single-tsetse-flies
#15
D Kaba, D Berté, B T D Ta, J Tellería, P Solano, J-P Dujardin
This is the first study to explore the potential of various geometric morphometrics methods to help the morphological diagnostic of tsetse species, vectors of human and animal trypanosomiases in sub-Saharan Africa. We compared landmarks, semilandmarks and outlines techniques on male and female samples of species, and suggested adapted strategies according to the countries and their own Glossina fauna. We could compare up to 7 taxa belonging to the three main subgenera of the Glossina genus: Nemorhina (5 species), Glossina (1 species) and Austenina (1 species)...
January 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27582103/both-clic4-and-clic5a-activate-erm-proteins-in-glomerular-endothelium
#16
Mahtab Tavasoli, Abass Al-Momany, Xin Wang, Laiji Li, John C Edwards, Barbara J Ballermann
The chloride intracellular channel (CLIC) 5A is expressed at very high levels in renal glomeruli, in both endothelial cells (EC) and podocytes. CLIC5A stimulates Rac1- and phosphatidylinositol (4,5)-bisphosphate-dependent ERM (ezrin, radixin, moesin) activation. ERM proteins, in turn, function in lumen formation and in the development of actin-based cellular projections. In mice lacking CLIC5A, ERM phosphorylation is profoundly reduced in podocytes, but preserved in glomerular EC. Since glomerular EC also express CLIC4, we reasoned that, if CLIC4 activates ERM proteins like CLIC5A, then CLIC4 could compensate for the CLIC5A loss in glomerular EC...
November 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27562892/a-typology-of-longitudinal-integrated-clerkships
#17
Paul Worley, Ian Couper, Roger Strasser, Lisa Graves, Beth-Ann Cummings, Richard Woodman, Pamela Stagg, David Hirsh
CONTEXT: Longitudinal integrated clerkships (LICs) represent a model of the structural redesign of clinical education that is growing in the USA, Canada, Australia and South Africa. By contrast with time-limited traditional block rotations, medical students in LICs provide comprehensive care of patients and populations in continuing learning relationships over time and across disciplines and venues. The evidence base for LICs reveals transformational professional and workforce outcomes derived from a number of small institution-specific studies...
September 2016: Medical Education
https://www.readbyqxmd.com/read/27552962/prognostic-indicators-for-mycosis-fungoides-in-a-greek-population
#18
V Nikolaou, E Papadavid, A Patsatsi, M Siakantaris, A Economidi, L Marinos, T Koletsa, E Georgiou, V Pappa, A Stratigos, C Antoniou
BACKGROUND: Mycosis fungoides (MF) is an indolent cutaneous lymphoma with excellent prognosis at early stages and much poorer outcome during disease progression. Old age, male sex and folliculotropism have been proposed as relevant prognostic factors; however, their exact effect remains debatable. OBJECTIVES: To evaluate MF prognostic indicators and survival rates in a Greek population. METHODS: Prognostic variables affecting survival rates were studied in 473 patients with MF diagnosed and treated by two academic referral centres in Greece...
May 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/27528072/parallelized-cytoindentation-using-convex-micropatterned-surfaces
#19
Bojing Jia, Tse-Luen Wee, Colton G Boudreau, Daniel J Berard, Adiel Mallik, David Juncker, Claire M Brown, Sabrina R Leslie
Here we present a high-throughput, parallelized cytoindentor for local compression of live cells. The cytoindentor uses convex lens-induced confinement (CLiC) to indent micrometer-sized areas in single cells and/or populations of cells with submicron precision. This is accomplished using micropatterned poly(dimethylsiloxane) (PDMS) films that are adhered to a convex lens to create arrays of extrusions referred to here as "posts." These posts caused local deformation of subcellular regions without any evidence of cell lysis upon CLiC indentation...
2016: BioTechniques
https://www.readbyqxmd.com/read/27492895/parental-tobacco-smoking-and-acute-myeloid-leukemia-the-childhood-leukemia-international-consortium
#20
Catherine Metayer, Eleni Petridou, Juan Manuel Mejía Aranguré, Eve Roman, Joachim Schüz, Corrado Magnani, Ana Maria Mora, Beth A Mueller, Maria S Pombo de Oliveira, John D Dockerty, Kathryn McCauley, Tracy Lightfoot, Emmanouel Hatzipantelis, Jérémie Rudant, Janet Flores-Lujano, Peter Kaatsch, Lucia Miligi, Catharina Wesseling, David R Doody, Maria Moschovi, Laurent Orsi, Stefano Mattioli, Steve Selvin, Alice Y Kang, Jacqueline Clavel
The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2...
August 15, 2016: American Journal of Epidemiology
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