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https://www.readbyqxmd.com/read/28091795/mood-spectrum-disorders-and-perception-of-pain
#1
Antonella Ciaramella
: Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
January 14, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28080969/an-active-inference-theory-of-allostasis-and-interoception-in-depression
#2
Lisa Feldman Barrett, Karen S Quigley, Paul Hamilton
In this paper, we integrate recent theoretical and empirical developments in predictive coding and active inference accounts of interoception (including the Embodied Predictive Interoception Coding model) with working hypotheses from the theory of constructed emotion to propose a biologically plausible unified theory of the mind that places metabolism and energy regulation (i.e. allostasis), as well as the sensory consequences of that regulation (i.e. interoception), at its core. We then consider the implications of this approach for understanding depression...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28078966/visual-and-cross-modal-cues-increase-the-identification-of-overlapping-visual-stimuli-in-balint-s-syndrome
#3
Daniela D'Imperio, Michele Scandola, Valeria Gobbetto, Cristina Bulgarelli, Matteo Salgarello, Renato Avesani, Valentina Moro
INTRODUCTION: Cross-modal interactions improve the processing of external stimuli, particularly when an isolated sensory modality is impaired. When information from different modalities is integrated, object recognition is facilitated probably as a result of bottom-up and top-down processes. The aim of this study was to investigate the potential effects of cross-modal stimulation in a case of simultanagnosia. METHOD: We report a detailed analysis of clinical symptoms and an (18)F-fluorodeoxyglucose (FDG) brain positron emission tomography/computed tomography (PET/CT) study of a patient affected by Balint's syndrome, a rare and invasive visual-spatial disorder following bilateral parieto-occipital lesions...
January 12, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28074464/investigation-of-hand-function-among-children-diagnosed-with-autism-spectrum-disorder-with-upper-extremity-trauma-history
#4
Meral Huri, Sedef Şahin, Hülya Kayıhan
BACKGROUND: The present study was designed to compare hand function in autistic children with history of upper extremity trauma with that of autistic children those who do not have history of trauma. METHODS: The study group included total of 65 children diagnosed with autism spectrum disorder (ASD) and was divided into 2 groups: children with trauma history (Group I) and control group (Group II) (Group I: n=28; Group II: n=37). Hand function was evaluated with 9-Hole Peg Test and Jebsen Hand Function Test...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28045463/neurogenetics-of-developmental-dyslexia-from-genes-to-behavior-through-brain-neuroimaging-and-cognitive-and-sensorial-mechanisms
#5
REVIEW
S Mascheretti, A De Luca, V Trezzi, D Peruzzo, A Nordio, C Marino, F Arrigoni
Developmental dyslexia (DD) is a complex neurodevelopmental deficit characterized by impaired reading acquisition, in spite of adequate neurological and sensorial conditions, educational opportunities and normal intelligence. Despite the successful characterization of DD-susceptibility genes, we are far from understanding the molecular etiological pathways underlying the development of reading (dis)ability. By focusing mainly on clinical phenotypes, the molecular genetics approach has yielded mixed results...
January 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28039782/reduced-sensitivity-to-social-priors-during-action-prediction-in-adults-with-autism-spectrum-disorders
#6
Valerian Chambon, Chlöé Farrer, Elisabeth Pacherie, Pierre O Jacquet, Marion Leboyer, Tiziana Zalla
An extensive amount of evidence has documented a diminished ability to predict and understand other people's action in individuals with autism spectrum disorders (ASD). Recently, two theoretical accounts, the "Hypo-priors" and the "Aberrant precision" hypotheses, have suggested that attenuated Bayesian priors or an imbalance of the precision ascribed to sensory evidence relative to prior expectations may be responsible for the atypical perceptual experience and difficulties with action understanding in ASD...
December 28, 2016: Cognition
https://www.readbyqxmd.com/read/28028198/sex-dependent-regulation-of-aromatase-mediated-synaptic-plasticity-in-the-basolateral-amygdala
#7
Roland A Bender, Lepu Zhou, Ricardo Vierk, Nicola Brandt, Alexander Keller, Christine E Gee, Michael K E Schäfer, Gabriele M Rune
: The basolateral amygdala (BLA) integrates sensory input from cortical and subcortical regions, a function that requires marked synaptic plasticity. Here we provide evidence that cytochrome P450 aromatase (AROM), the enzyme converting testosterone to 17β-estradiol (E2), contributes to the regulation of this plasticity in a sex-specific manner. We show that AROM is expressed in the BLA, particularly in the basolateral nucleus (BL), in male and female rodents. Systemic administration of the AROM-inhibitor letrozole reduced spine synapse density in the BL of adult female mice, but not in the BL of male mice...
December 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28018906/chaperonopathies-spotlight-on-hereditary-motor-neuropathies
#8
REVIEW
Vincenzo Lupo, Carmen Aguado, Erwin Knecht, Carmen Espinós
Distal hereditary motor neuropathies (dHMN) are a group of rare hereditary neuromuscular disorders characterized by an atrophy that affects peroneal muscles in the absence of sensory symptoms. To date, 23 genes are thought to be responsible for dHMN, four of which encode chaperones: DNAJB2, which encodes a member of the HSP40/DNAJ co-chaperone family; and HSPB1, HSPB3, and HSPB8, encoding three members of the small heat shock protein family. While around 30 different mutations in HSPB1 have been identified, the remaining three genes are altered in many fewer cases...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28011743/5-ht2c-receptor-knockdown-in-the-amygdala-inhibits-neuropathic-pain-related-plasticity-and-behaviors
#9
Guangchen Ji, Wei Zhang, Lenin Mahimainathan, Madhusudhanan Narasimhan, Takaki Kiritoshi, Xiuzhen Fan, Jigong Wang, Thomas A Green, Volker Neugebauer
: Neuroplasticity in the amygdala drives pain-related behaviors. The central nucleus (CeA) serves major amygdala output functions and can generate emotional-affective behaviors and modulate nocifensive responses. The CeA receives excitatory and inhibitory inputs from the basolateral nucleus (BLA), and serotonin receptor subtype 5-HT2CR in the BLA, but not CeA, has been implicated anxiogenic behaviors and anxiety disorders. Here we tested the hypothesis that 5-HT2CR in the BLA plays a critical role in CeA plasticity and neuropathic pain behaviors in the rat spinal nerve ligation (SNL) model...
December 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27992839/psychosis-prediction-in-secondary-mental-health-services-a-broad-comprehensive-approach-to-the-at-risk-mental-state-syndrome
#10
M Francesconi, A Minichino, R E Carrión, R Delle Chiaie, A Bevilacqua, M Parisi, S Rullo, F Saverio Bersani, M Biondi, K Cadenhead
BACKGROUND: Accuracy of risk algorithms for psychosis prediction in "at risk mental state" (ARMS) samples may differ according to the recruitment setting. Standardized criteria used to detect ARMS individuals may lack specificity if the recruitment setting is a secondary mental health service. The authors tested a modified strategy to predict psychosis conversion in this setting by using a systematic selection of trait-markers of the psychosis prodrome in a sample with a heterogeneous ARMS status...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27988382/the-vagus-nerve-in-appetite-regulation-mood-and-intestinal-inflammation
#11
REVIEW
Kirsteen N Browning, Simon Verheijden, Guy E Boeckxstaens
Although the gastrointestinal (GI) tract contains intrinsic neural plexuses that allow a significant degree of independent control over GI functions, the central nervous system provides extrinsic neural inputs that modulate, regulate and integrate these functions. In particular, the vagus nerve (VN) provides the parasympathetic innervation to the GI tract, co-ordinates the complex interactions between central and peripheral neural control mechanisms. This review will discuss the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood and the immune system, as well as the pathophysiological outcomes of VN dysfunction resulting in obesity, mood disorders and inflammation...
December 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27918366/oculographic-clinical-test-of-sensory-integration-and-balance-and-computerized-dynamic-posturography-findings-in-patients-with-psoriatic-arthritis
#12
Juan Carlos Amor-Dorado, Maria P Barreira-Fernandez, Javier Llorca, Miguel A Gonzalez-Gay
OBJECTIVE: To assess the frequency and characteristics of the oculographic findings and the usefulness of the clinical test of sensory integration and balance (CTSIB) for the evaluation of balance in patients with psoriatic arthritis (PsA) by comparing this test with the computerized dynamic posturography (CDP). STUDY DESIGN: A series of consecutive patients that fulfilled the Moll and Wright criteria for PsA and matched controls were studied. SETTING: The study was performed at the Otolaryngology Division of a tertiary reference center...
December 1, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27909646/the-neural-mechanisms-of-meditative-practices-novel-approaches-for-healthy-aging
#13
REVIEW
Bianca P Acevedo, Sarah Pospos, Helen Lavretsky
OBJECTIVES: Meditation has been shown to have physical, cognitive, and psychological health benefits that can be used to promote healthy aging. However, the common and specific mechanisms of response remain elusive due to the diverse nature of mind-body practices. METHODS: In this review, we aim to compare the neural circuits implicated in focused-attention meditative practices that focus on present-moment awareness to those involved in active-type meditative practices (e...
2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27908847/homeostasis-of-the-gut-barrier-and-potential-biomarkers
#14
Jerry M Wells, Robert J Brummer, Muriel Derrien, Thomas T MacDonald, Freddy Troost, Patrice D Cani, Vassilia Theodorou, Jan Dekker, Agnes Méheust, Willem M de Vos, Annick Mercenier, Arjen Nauta, Clara L Garcia-Rodenas
The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of sIgA and antimicrobial peptides and proteins. With exception of sIgA the expression of these protective barrier factors is largely controlled by innate immune recognition of microbial molecular ligands. Several specialized adaptations and checkpoints are operating in the mucosa to scale the immune response according to the threat and prevent overreaction to the trillions of symbionts inhabiting the human intestine...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27896947/reduced-modulation-of-thalamocortical-connectivity-during-exposure-to-sensory-stimuli-in-asd
#15
Shulamite A Green, Leanna Hernandez, Susan Y Bookheimer, Mirella Dapretto
Recent evidence for abnormal thalamic connectivity in autism spectrum disorders (ASD) and sensory processing disorders suggests the thalamus may play a role in sensory over-responsivity (SOR), an extreme negative response to sensory stimuli, which is common in ASD. However, there is yet little understanding of changes in thalamic connectivity during exposure to aversive sensory inputs in individuals with ASD. In particular, the pulvinar nucleus of the thalamus is implicated in atypical sensory processing given its role in selective attention, regulation, and sensory integration...
November 29, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27876453/-i-can-t-tell-whether-it-s-my-hand-a-pilot-study-of-the-neurophenomenology-of-body-representation-during-the-rubber-hand-illusion-in-trauma-related-disorders
#16
Daniela Rabellino, Sherain Harricharan, Paul A Frewen, Dalila Burin, Margaret C McKinnon, Ruth A Lanius
BACKGROUND: Early traumatic experiences are thought to be causal factors in the development of trauma-related dissociative experiences, including depersonalization and derealization. The rubber hand illusion (RHI), a well-known paradigm that measures multi-sensorial integration of a rubber hand into one's own body representation, has been used to investigate alterations in the experience of body ownership and of body representation. Critically, however, it has never been studied in individuals with trauma-related disorders...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27875927/what-is-being-trained-how-divergent-forms-of-plasticity-compete-to-shape-locomotor-recovery-after-spinal-cord-injury
#17
J Russell Huie, Kazuhito Morioka, Jenny Haefeli, Adam R Ferguson
Spinal cord injury (SCI) is a devastating syndrome that produces dysfunction in motor and sensory systems, manifesting as chronic paralysis, sensory changes, and pain disorders. The multi-faceted and heterogeneous nature of SCI has made effective rehabilitative strategies challenging. Work over the last 40 years has aimed to overcome these obstacles by harnessing the intrinsic plasticity of the spinal cord to improve functional locomotor recovery. Intensive training after SCI facilitates lower extremity function and has shown promise as a tool for retraining the spinal cord by engaging innate locomotor circuitry in the lumbar cord...
January 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27871729/an-integrative-tinnitus-model-based-on-sensory-precision
#18
REVIEW
William Sedley, Karl J Friston, Phillip E Gander, Sukhbinder Kumar, Timothy D Griffiths
Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'...
December 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27867664/the-case-for-musical-instrument-training-in-cerebral-palsy-for-neurorehabilitation
#19
REVIEW
Ana Alves-Pinto, Varvara Turova, Tobias Blumenstein, Renée Lampe
Recent imaging studies in cerebral palsy (CP) have described several brain structural changes, functional alterations, and neuroplastic processes that take place after brain injury during early development. These changes affect motor pathways as well as sensorimotor networks. Several of these changes correlate with behavioral measures of motor and sensory disability. It is now widely acknowledged that management of sensory deficits is relevant for rehabilitation in CP. Playing a musical instrument demands the coordination of hand movements with integrated auditory, visual, and tactile feedback, in a process that recruits multiple brain regions...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27866043/sensory-processing-disorders-in-children-with-cerebral-palsy
#20
Sílvia Leticia Pavão, Nelci Adriana Cicuto Ferreira Rocha
OBJECTIVE: To evaluate sensory processing in children with CP using the Sensory Profile questionnaire and to compare results with the ones of children with typical development (TD). METHODS: We assessed sensory processing of 59 TD children and 43 CP children using the Sensory Profile, a standardized parent reporting measure that records children's responses to sensory events in daily life. Mann-Whitney test was used to compare the results of sensory processing evaluation among the groups...
November 17, 2016: Infant Behavior & Development
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