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Peritoneal surface malignancy

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https://www.readbyqxmd.com/read/27916165/effectiveness-and-failures-of-a-fast-track-protocol-after-cytoreduction-and-hyperthermic-intraoperative-intraperitoneal-chemotherapy-in-patients-with-peritoneal-surface-malignancies
#1
REVIEW
P A Cascales-Campos, P A Sánchez-Fuentes, J Gil, E Gil, V López-López, N Rodriguez Gomez-Hidalgo, D Fuentes, P Parrilla
BACKGROUND: The aim of this study was to analyze the results short term perioperative of patients with peritoneal surface malignancies undergoing cytoreduction with peritonectomy and HIPEC under a controlled fast track protocol and evaluate the factors related to the failure of implementation of the protocol. PATIENTS AND METHOD: We prospectively analyzed a consecutive series of patients (N = 156) with peritoneal surface malignancies treated by cytoreductive surgery with peritonectomy procedures and HIPEC from September 2008 until December 2014, in whom a fast track protocol was implemented...
December 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27913947/preclinical-evaluation-of-cathepsin-based-fluorescent-imaging-system-for-cytoreductive-surgery
#2
Carlos H F Chan, Lukas F Liesenfeld, Isabel Ferreiro-Neira, James C Cusack
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal surface malignancies. The ability to detect microscopic foci of peritoneal metastasis intraoperatively may ensure the completeness of cytoreduction. In this study, we evaluated the suitability of a hand-held cathepsin-based fluorescent imaging system for intraoperative detection of appendiceal and colorectal peritoneal metastasis. METHODS: Peritoneal tumors and normal peritoneal tissues were collected from patients with appendiceal and colorectal peritoneal metastasis...
December 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27900630/current-delivery-of-hyperthermic-intraperitoneal-chemotherapy-with-cytoreductive-surgery-cs-hipec-and-perioperative-practices-an-international-survey-of-high-volume-surgeons
#3
Allison H Maciver, Eisar Al-Sukhni, Jesus Esquivel, Joseph J Skitzki, John M Kane, Valerie A Francescutti
BACKGROUND: Cytoreductive surgery and heated intraperitoneal chemotherapy (CS/HIPEC) is performed for selected indications at a limited number of specialized centers worldwide. Currently there is no standardized approach to the perioperative care process. We sought to capture current practices in the perioperative management of patients who undergo CS/HIPEC at high-volume centers. METHODS: Surgeon members of the American Society of Peritoneal Surface Malignancies working at high-volume CS/HIPEC centers (>10 cases/year) were invited to complete an online survey...
November 29, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27889017/staging-procedures-in-patients-with-mucinous-borderline-tumors-of-the-ovary-do-not-reveal-peritoneal-or-omental-disease
#4
Koen De Decker, Stephanie Speth, Henk G Ter Brugge, Joost Bart, Leon F A G Massuger, Marjolein Kleppe, Loes F S Kooreman, Roy F P M Kruitwagen, Arnold-Jan Kruse
OBJECTIVES: Staging in case of a borderline tumor of the ovary (BOT) is a controversial issue. Upstaging is not uncommon, but this occurs especially with presumed stage I serous borderline tumors. There are only a few documented cases of BOTs of non-serous histology that were not confined to the ovary. The aim of this study was to assess the incidence of non-invasive and invasive implants in the omentum and other (extra)pelvic peritoneal surfaces in patients with a mucinous BOT (mBOT)...
November 23, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27872533/role-of-imaging-in-peritoneal-surface-malignancies
#5
Santosh Krishnamurthy, Raghav Balasubramaniam
Imaging plays a vital role in the evaluation of peritoneal malignancies. The presence of peritoneal metastases (PM) alters tumor staging, with direct implications in treatment choice and prognosis. Cytoreductive surgery (CRS) and Hyperthermic intraperitoneal chemotherapy (HIPEC) as a combined modality treatment have led to prolonged survival and even cure in selected patients with PM. Better outcomes are seen in patients with limited disease spread. Therefore, early diagnosis of peritoneal tumor seeding is essential...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27807494/ovarian-carcinosarcoma-and-its-association-with-mature-cystic-teratoma-and-primary-tubal-carcinoma
#6
Sunida Rewsuwan, Nopporn Satabongkoch, Prapaporn Suprasert, Surapan Khunamornpong
Introduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare. Case Report. A 69-year-old woman presented with a pelvic mass. An abdominal computerized tomographic scan detected a 15 cm right pelvic mass which was suggestive of malignant transformation of a dermoid cyst. Intraoperative, bilateral ovarian masses (left 10 cm and right 12 cm) with diffuse peritoneal metastatic nodules were identified...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27792292/the-american-society-of-peritoneal-surface-malignancies-multi-institution-evaluation-of-1-051-advanced-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hipec-an-introduction-of-the-peritoneal-surface-disease-severity-score
#7
Richard Sleightholm, Jason M Foster, Lynette Smith, Wim Ceelen, Marcello Deraco, Yusuf Yildirim, Edward Levine, Cristobal Muñoz-Casares, Olivier Glehen, Asish Patel, Jesus Esquivel
BACKGROUND: Standard treatment for ovarian epithelial cancer (OEC) consists of cytoreductive surgery (CRS) and a platinum-taxane chemotherapy combination. There is increasing interest in evaluating hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with stage IIIC/IV disease. The peritoneal surface disease severity score (PSDSS) was introduced as a basis to improve patient selection for this therapy in OEC. METHODS: The charts of 1,051 patients with advanced OEC who underwent CRS/HIPEC were retrospectively evaluated using the following preoperatively obtained criteria: symptoms, peritoneal dissemination, and tumor histology...
December 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27665187/silk-suture-granuloma-with-false-positive-findings-on-pet-ct-accompanied-by-peritoneal-metastasis-after-colon-cancer-surgery
#8
Sohei Matsuura, Kazuhito Sasaki, Hiroshi Kawasaki, Hideki Abe, Hideo Nagai, Fuyo Yoshimi
INTRODUCTION: Suture granuloma is a rare benign tumor caused by suture material, which usually appears several months or years after surgery. PRESENTATION OF CASE: A 71-year-old man underwent sigmoidectomy and partial hepatectomy (S6) for sigmoid colon cancer and synchronous liver metastasis at a previous hospital. At 4 postoperative months, surveillance computed tomography (CT) revealed a suspicious tumor at the hepatic resection stump. He was referred to our hospital for further examinations and treatments...
September 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27544053/malignant-mesothelioma-effusions-are-infiltrated-by%C3%A2-cd3-t-cells-highly-expressing-pd-l1-and-the-pd-l1-tumor-cells-within-these-effusions-are-susceptible-to-adcc-by-the-anti-pd-l1-antibody-avelumab
#9
Swati Khanna, Anish Thomas, Daniel Abate-Daga, Jingli Zhang, Betsy Morrow, Seth M Steinberg, Augusto Orlandi, Patrizia Ferroni, Jeffrey Schlom, Fiorella Guadagni, Raffit Hassan
INTRODUCTION: The functional aspects of programmed death 1 (PD-1) and PD ligand 1 (PD-L1) immune checkpoints in malignant mesothelioma have not been studied. METHODS: Tumor samples from 65 patients with mesothelioma were evaluated for PD-L1 expression by immunohistochemistry, and its prognostic significance was examined. Malignant effusions from patients with pleural and peritoneal mesothelioma were evaluated for PD-1-positive and PD-L1-positive infiltrating lymphocytes and their role in inducing PD-L1 expression in tumor cells...
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27540559/asbestos-fiber-preparation-methods-affect-fiber-toxicity
#10
Ashkan Salamatipour, Sanjay K Mohanty, Ralph A Pietrofesa, David R Vann, Melpo Christofidou-Solomidou, Jane K Willenbring
To measure the toxic potential of asbestos fibers-a known cause of asbestosis, lung cancer, and malignant mesothelioma-asbestos minerals are generally first ground down to small fibers, but it is unknown whether the grinding condition itself changes the fiber toxicity. To evaluate this, we ground chrysotile ore with or without water for 5-30 min and quantified asbestos-induced reactive oxygen species generation in elicited murine peritoneal macrophages as an indicator of fiber toxicity. The toxicity of dry-ground fibers was higher than the toxicity of wet-ground fibers...
July 12, 2016: Environmental Science & Technology Letters
https://www.readbyqxmd.com/read/27528813/evolution-of-management-in-peritoneal-surface-malignancies
#11
REVIEW
Emel Canbay, Bahar Canbay Torun, Ege Sinan Torun, Yutaka Yonemura
Management of peritoneal surface malignancies has gradually evolved by the introduction of cytoreductive surgery in combination with intraperitoneal chemotherapy applications. Recently, peritoneal metastases of intraabdominal solid organ tumors and primary peritoneal malignancies such as peritoneal mesothelioma are being treated with this new approach. Selection criteria are important to reduce morbidity and mortality rates of patients who will experience minimal or no benefit from these combined treatment modalities...
2016: Ulusal Cerrahi Dergisi
https://www.readbyqxmd.com/read/27438989/a-histomorphologic-grading-system-that-predicts-overall-survival-in-diffuse-malignant-peritoneal-mesothelioma-with-epithelioid-subtype
#12
Kari Valente, Aaron U Blackham, Edward Levine, Greg Russell, Konstantinos I Votanopoulos, John H Stewart, Perry Shen, Kim R Geisinger, Sahussapont J Sirintrapun
Diffuse malignant peritoneal mesothelioma (MPeM) is rare and arises from peritoneal serosal surfaces. Although it shares similar histomorphology with its counterpart, malignant pleural mesothelioma, etiologies, clinical courses, and therapies differ. Nuclear grading and level of mitoses have been correlated with prognosis in malignant pleural mesothelioma with epithelioid subtype. Whether nuclear grading and level of mitoses correlate with prognosis in MPeM is still unknown. Our study utilizes a 2 tier system incorporating nuclear features and level of the mitoses to stratify cases of MPeM with epithelioid subtype...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27409239/ectopic-pregnancy-with-associated-gestational-choriocarcinoma-in-a-california-sea-lion-zalophus-californianus
#13
Vanessa A Fravel, Linda J Lowenstine, Amanda Koehne
A wild-born, captive-reared, 14 yr old, primiparous female California sea lion Zalophus californianus presented for anorexia of 14 d duration and abdominal distention. Routine complete blood cell count revealed leukocytosis with a neutrophilia, and serum chemistry revealed hypoalbumenemia and hyponatremia. Treatment with broad spectrum antibiotics and non-steroidal anti-inflammatories were started, but the animal continued to decline. Abdominal radiographs revealed a mature mineralized fetal skull and spine in the caudal abdomen and abdominal ultrasound revealed ascites but could not confirm the fetus...
July 7, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27385136/evaluation-of-cisplatin-plasma-levels-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Francesco Fleres, Edoardo Saladino, Rosaria Catanoso, Vincenzo Arcoraci, Tommaso Mandolfino, Eugenio Cucinotta, Antonio Macrì
Introduction Peritoneal surface malignancies have long been regarded as incurable, however, they can be treated with cytoreductive surgery in addition to hyperthermic intraperitoneal chemotherapy. This approach is associated with an increase in morbidity and mortality, unless hyperhydration is provided in a timely manner. Methods Cisplatin (CDDP) is the most widely used chemotherapeutic agent. Plasma levels of cisplatin (CDDP), a widely used chemotherapeutic agent, were measured before, during, and after the procedure...
February 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27354626/flow-cytometric-analysis-of-ovarian-cancer-ascites-response-of-mesothelial-cells-and-macrophages-to-cancer
#15
Kazunori Hashimoto, Kazuho Honda, Hideo Matsui, Yoji Nagashima, Hideaki Oda
AIM: To evaluate the response of mesothelial cells and macrophages in the peritoneal fluid of epithelial ovarian malignant tumors using flow cytometry immunophenotyping. MATERIALS AND METHODS: Thirteen peritoneal fluid samples collected from surgery or scentesis of epithelial ovarian malignant tumor patients were assayed using flow cytometry. Cytological and pathological diagnosis was performed on the same ascites and resected tumor specimens. Samples were treated with antibodies against established markers of mesothelial cells (podoplanin), macrophages (CD14) and the hyaluronan receptor (CD44)...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27338636/adenocarcinoma-ex-goblet-cell-carcinoid-appendiceal-type-crypt-cell-adenocarcinoma-is-a-morphologically-distinct-entity-with-highly-aggressive-behavior-and-frequent-association-with-peritoneal-intra-abdominal-dissemination-an-analysis-of-77-cases
#16
Michelle D Reid, Olca Basturk, Walid L Shaib, Yue Xue, Serdar Balci, Hye-Jeong Choi, Gizem Akkas, Bahar Memis, Brian S Robinson, Bassel F El-Rayes, Charles A Staley, Christopher A Staley, Joshua H Winer, Maria C Russell, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
High-grade versions of appendiceal goblet cell carcinoids ('adenocarcinoma ex-goblet cell carcinoids') are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29-84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n=3) and lung (n=1) were uncommon and none arose in adenomatous lesions...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27330364/treatment-of-peritoneal-surface-malignancies-with-hyperthermic-intraperitoneal-chemotherapy-current-perspectives
#17
REVIEW
J Spiliotis, E Halkia, E de Bree
Peritoneal carcinomatosis (ptc) represents advanced malignant disease and has generally been associated with a grim prognosis. Peritoneal surface malignancy is often the major source of morbidity and mortality; it is of major concern in cancer management. Although ptc is categorized as metastatic disease, it represents a special disease pattern considered to be a locoregional disease limited to the abdominal cavity. The combination of cytoreductive surgery (crs) and intraoperative hyperthermic intraperitoneal chemotherapy (hipec) has successfully been used as locoregional treatment for selected patients with ptc from gastric, colorectal, and ovarian cancer; with mesothelioma; and with pseudomyxoma peritonei...
June 2016: Current Oncology
https://www.readbyqxmd.com/read/27284430/leiomyomatosis-peritonealis-disseminata-a-case-report-and-review-of-the-literature
#18
Chaoying Wu, Xuyin Zhang, Xiang Tao, Jingxin Ding, Keqin Hua
Leiomyomatosis peritonealis disseminata (LPD) is a rare smooth muscle tumor, which is characterized by the dissemination of multiple smooth muscle-like nodules throughout the omental and peritoneal surfaces. The present report describes the case of a 33-year-old woman who had previously undergone laparoscopic myomectomy due to a bizarre leiomyoma. Five years after the initial operation, the patient was referred to our hospital with irregular episodes of right abdominal pain. As the presentation was highly suspicious of malignant uterine tumor metastasis or LPD, the patient subsequently underwent laparoscopic total hysterectomy, bilateral salpingo-oopherectomy, omental resection and excision of some of the disseminated nodules...
June 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27221929/5-aminolevulinic-acid-fluorescence-in-detection-of-peritoneal-metastases
#19
Yutaka Yonemura, Emel Canbay, Haruaki Ishibashi, Eisei Nishino, Yoshio Endou, Shouzou Sako, Shun-Ichirou Ogura
BACKGROUND: The value of 5-aminolevulinic acid (ALA) in fluorescence detection of peritoneal metastases and the underlying mechanisms were evaluated in patients with peritoneal surface malignancies. MATERIALS AND METHODS: Oral 5-ALA was administered at a concentration of 20 mg ⁄kg body weight with 50 ml of water 2 hours prior to surgery (n=115). The diagnostic value of 5-ALA based fluorescence production was evaluated following white light inspection during prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27186409/potentiation-of-chemotherapeutics-by-bromelain-and-n-acetylcysteine-sequential-and-combination-therapy-of-gastrointestinal-cancer-cells
#20
Afshin Amini, Samar Masoumi-Moghaddam, Anahid Ehteda, Winston Liauw, David Lawson Morris
Intraperitoneal chemotherapy together with cytoreductive surgery is the standard of care for a number of peritoneal surface malignancies. However, this approach fails to maintain the complete response and disease recurs due to microscopic residual disease. Although safer than systemic chemotherapy regimens, locoregional treatment with chemotherapeutics can induce toxicity which is a major concern affecting the patient's treatment protocol and outcome. For an enhanced treatment efficacy, efforts should be made to maximize cytotoxic effects of chemotherapeutic agents on tumor cells while minimizing their toxic effects on host cells...
2016: American Journal of Cancer Research
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