Kate Stanley, Joseph Hostyk, Linh Tran, Marta Amengual-Gual, Patricia Dugan, Justice Clark, Hyunmi Choi, Dmitry Tchapyjnikov, Piero Perucca, Cecilia Fernandes, Danielle Andrade, Orrin Devinsky, Gianpiero L Cavalleri, Chantal Depondt, Arjune Sen, Terence O'Brien, Erin Heinzen, Tobias Loddenkemper, David B Goldstein, Mohamed A Mikati, Norman Delanty
Large international consortia examining the genomic architecture of the epilepsies focus on large diagnostic subgroupings such as "all focal epilepsy" and "all genetic generalized epilepsy". In addition, phenotypic data are generally entered into these large discovery databases in a unidirectional manner at one point in time only. However, there are many smaller phenotypic subgroupings in epilepsy, many of which may have unique genomic risk factors. Such a subgrouping or "microphenotype" may be defined as an uncommon or rare phenotype that is well recognized by epileptologists and the epilepsy community, and which may or may not be formally recognized within the International League Against Epilepsy classification system...
September 27, 2021: American Journal of Medical Genetics. Part A