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https://www.readbyqxmd.com/read/28208146/serum-lipid-fractions-and-cerebral-microbleeds-in-a-healthy-japanese-population
#1
Shingo Mitaki, Atsushi Nagai, Hiroaki Oguro, Shuhei Yamaguchi
BACKGROUND: Cerebral microbleeds (CMBs) are associated with focal hemosiderin deposits and represent a form of cerebral small vessel disease. To date, indefinite and inconsistent reports are available regarding the association between serum lipid fractions and CMBs. In addition, these previous studies did not include Asian populations, who may have a higher risk of cerebral hemorrhage. The purpose of this study was to examine the associations between serum lipid fractions and CMBs in healthy Japanese subjects...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28208139/mri-based-neuroanatomical-predictors-of-dysphagia-dysarthria-and-aphasia-in-patients-with-first-acute-ischemic-stroke%C3%A2
#2
Heather L Flowers, Mohammed A AlHarbi, David Mikulis, Frank L Silver, Elizabeth Rochon, David Streiner, Rosemary Martino
BACKGROUND: Due to the high post-stroke frequency of dysphagia, dysarthria, and aphasia, we developed comprehensive neuroanatomical, clinical, and demographic models to predict their presence after acute ischemic stroke. METHODS: The sample included 160 randomly selected first-ever stroke patients with confirmed infarction on magnetic resonance imaging from 1 tertiary stroke center. We documented acute lesions within 12 neuroanatomical regions and their associated volumes...
February 16, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/28202818/-hypoglycemic-hemiplegia
#3
Eriko Sugawara, Yosuke Kudo, Ken Johkura
Hypoglycemia may cause acute hemiplegia. The most common diffusion-weighted MR imaging finding in patients with hypoglycemic hemiplegia is the hyperintense lesion involving the internal capsule, mimicking acute ischemic stroke. Thus, in patients with acute onset hemiplegia, it is important to differentiate hypoglycemia on arrival by immediate blood glucose measurement. It has recently been shown that hypoglycemic brain injury start in large white matter tracts such as internal capsule and spread throughout the whole brain, including the gray matter...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28196940/intravoxel-incoherent-motion-imaging-in-small-vessel-disease-microstructural-integrity-and-microvascular-perfusion-related-to-cognition
#4
C Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H Backes, Erik I Hoff, Tobien Schreuder, Cécile R L P N Jeukens, Jacobus F A Jansen, Robert J van Oostenbrugge
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously...
February 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28188307/early-life-risk-factors-for-cerebrovascular-disease-a-systematic-review-and-meta-analysis
#5
Ellen V Backhouse, Caroline A McHutchison, Vera Cvoro, Susan D Shenkin, Joanna M Wardlaw
OBJECTIVE: Cerebrovascular disease (CVD) causes subclinical brain vascular lesions detected using neuroimaging and childhood factors may increase later CVD risk. METHODS: We searched MEDLINE, PsycINFO, and EMBASE, and meta-analyzed all available evidence on childhood (premorbid) IQ, socioeconomic status (SES), education, and subclinical CVD in later life. Overall odds ratios (OR), mean difference or correlation, and 95% confidence intervals (CIs) were calculated using random effects methods...
February 10, 2017: Neurology
https://www.readbyqxmd.com/read/28180080/simultaneous-investigation-of-microvasculature-and-parenchyma-in-cerebral-small-vessel-disease-using-intravoxel-incoherent-motion-imaging
#6
Sau May Wong, C Eleana Zhang, Frank C G van Bussel, Julie Staals, Cécile R L P N Jeukens, Paul A M Hofman, Robert J van Oostenbrugge, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 ± 11 y) and thirty-nine controls (age 69 ± 12 y) underwent IVIM imaging (3T)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28174033/acute-hypotonia-in-an-infant
#7
Jimme Sierakowski, Jason Arthur, Todd Wylie
BACKGROUND: Acute flaccid myelitis (AFM) is increasing in incidence in the United States and presenting to emergency departments (EDs) across the country. This clinical entity presents as acute paralysis, with magnetic resonance imaging changes in the gray matter only in children younger than 21 years of age. The etiology is unknown, although preceding viral illnesses are common. There are no consensus guidelines regarding treatment. CASE REPORT: A 4-month-old girl presented with decreased bilateral arm movement...
February 4, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28169884/mri-progression-of-cerebral-small-vessel-disease-and-cognitive-decline-in-patients-with-hypertension
#8
Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W de Leeuw, Abraham A Kroon, Robert J van Oostenbrugge
OBJECTIVE: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, which are MRI markers of cerebral small vessel disease. Studies into associations between presence or progression of these MRI markers and cognitive decline in hypertensive patients are rare. We investigated the association of baseline presence and progression of MRI markers of cerebral small vessel disease with cognitive decline over 4 years in patients with hypertension...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28168372/high-b-value-diffusion-weighted-imaging-in-progressive-multifocal-leukoencephalopathy-in-hiv-patients
#9
Claudia Godi, Enrico De Vita, Enrico Tombetti, Indran Davagnanam, Lewis Haddow, Hans Rolf Jäger
OBJECTIVES: An ill-defined hyperintense edge and hypointense core on diffusion-weighted imaging (DWI) is typical of progressive multifocal leukoencephalopathy (PML). We aimed to investigate whether a b-value of 3,000 s/mm(2) (b3000) can improve visualisation of PML, or provide different structural information compared to 1,000 s/mm(2) (b1000). METHODS: We retrospectively identified HIV-positive patients with confirmed PML studied under a clinical protocol including both b1000 and b3000 DWI...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28166312/association-between-subclinical-cardiac-biomarkers-and-clinically-manifest-cardiac-diseases-with-cortical-cerebral-microinfarcts
#10
Saima Hilal, Yuek Ling Chai, Susanne van Veluw, Muhammad Amin Shaik, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Arthur Mark Richards, Geert Jan Biessels, Christopher Chen
Importance: Subclinical and clinical cardiac diseases have been previously linked to magnetic resonance imaging (MRI) manifestations of cerebrovascular disease, such as lacunes and white matter hyperintensities, as well as dementia. Cortical cerebral microinfarcts (CMIs), a novel MRI marker of cerebral vascular disease, have not been studied, to date, in relation to subclinical and clinical cardiac diseases. Objective: To examine the association of blood biomarkers of subclinical cardiac disease and clinically manifest cardiac diseases with CMIs graded on 3-T MRI in a memory clinic population...
February 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28157096/only-white-matter-hyperintensities-predicts-post-stroke-cognitive-performances-among-cerebral-small-vessel-disease-markers-results-from-the-tabasco-study
#11
Jeremy Molad, Efrat Kliper, Amos D Korczyn, Einor Ben Assayag, Dafna Ben Bashat, Shani Shenhar-Tsarfaty, Orna Aizenstein, Ludmila Shopin, Natan M Bornstein, Eitan Auriel
BACKGROUND: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). OBJECTIVE: The aim of this study was to determine whether adding other SVD markers to WMH improves prediction of post-stroke cognitive performances. METHODS: Consecutive first-ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28156249/utility-of-mri-based-disproportionately-enlarged-subarachnoid-space-hydrocephalus-scoring-for-predicting-prognosis-after-surgery-for-idiopathic-normal-pressure-hydrocephalus-clinical-research
#12
Narihide Shinoda, Osamu Hirai, Shinya Hori, Kazuyuki Mikami, Toshiaki Bando, Daisuke Shimo, Takahiro Kuroyama, Yoji Kuramoto, Masato Matsumoto, Yasushi Ueno
OBJECTIVE The presence of disproportionately enlarged subarachnoid space hydrocephalus (DESH) on brain imaging is a recognized finding of idiopathic normal pressure hydrocephalus (iNPH), but the features of DESH can vary across patients. The aim of this study was to evaluate the utility of MRI-based DESH scoring for predicting prognosis after surgery. METHODS In this single-center, retrospective cohort study, the DESH score was determined by consensus between a group of neurosurgeons, neurologists, and a neuroradiologist based on the preoperative MRI findings of the patients with suspected iNPH...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28154284/chronic-graft-versus-host-disease-presenting-with-multiple-punctate-intracranial-lesions-on-contrast-enhanced-magnetic-resonance-imaging
#13
Makoto Terada, Kiyotaka Nakamagoe, Naoshi Obara, Shinichi Ogawa, Noriaki Sakamoto, Taiki Sato, Seitaro Nohara, Shigeru Chiba, Akira Tamaoka
Central nervous system graft-versus-host disease can present quite a diagnostic challenge. We herein present a case of histologically-confirmed chronic graft versus host disease (GVHD) involving the central nervous system that occurred at 19 months after peripheral blood stem cell transplantation. Cranial magnetic resonance imaging showed areas of confluent hyperintensity in the deep/subcortical white matter with multiple punctate and curvilinear gadolinium enhancements, suggesting the disruption of the blood-brain barrier...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28143497/gait-disorders-in-the-elderly-and-dual-task-gait-analysis-a-new-approach-for-identifying-motor-phenotypes
#14
Bernard Auvinet, Claude Touzard, François Montestruc, Arnaud Delafond, Vincent Goeb
BACKGROUND: Gait disorders and gait analysis under single and dual-task conditions are topics of great interest, but very few studies have looked for the relevance of gait analysis under dual-task conditions in elderly people on the basis of a clinical approach. METHODS: An observational study including 103 patients (mean age 76.3 ± 7.2, women 56%) suffering from gait disorders or memory impairment was conducted. Gait analysis under dual-task conditions was carried out for all patients...
January 31, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28142144/do-lacunar-infarcts-have-different-aetiologies-risk-factor-profiles-of-lacunar-infarcts-in-deep-white-matter-and-basal-ganglia-the-second-manifestations-of-arterial-disease-magnetic-resonance-study
#15
Raoul P Kloppenborg, Paul J Nederkoorn, Anne M Grool, Laurens J L De Cocker, Willem P T M Mali, Yolanda van der Graaf, Mirjam I Geerlings
BACKGROUND: Evidence suggests that lacunar infarcts have different etiologies, possibly related to their anatomical location and vascular territory. We investigated the risk factor profiles of patients with new lacunar infarcts in the basal ganglia and deep white matter. METHODS: Within the Second Manifestations of ARTerial disease-Magnetic Resonance study, a prospective cohort on brain changes on MRI in patients with symptomatic atherosclerotic disease, 679 patients (57 ± 9 years) had vascular screening and MRI at baseline and after a mean follow-up of 3...
January 31, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28134332/impact-of-small-vessel-disease-in-the-brain-on-gait-and-balance
#16
Daniela Pinter, Stuart J Ritchie, Fergus Doubal, Thomas Gattringer, Zoe Morris, Mark E Bastin, Maria Del C Valdés Hernández, Natalie A Royle, Janie Corley, Susana Muñoz Maniega, Alison Pattie, David A Dickie, Julie Staals, Alan J Gow, John M Starr, Ian J Deary, Christian Enzinger, Franz Fazekas, Joanna Wardlaw
Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subjects from the Lothian Birth Cohort 1936 at the age of 71-74 years who had undergone comprehensive risk factor assessment, gait and balance assessment as well as brain MRI. We investigated the impact of individual SVD markers (white matter hyperintensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structural brain MRI and of a global SVD score on the patients' performance...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28131561/-fragile-x-syndrome-and-white-matter-abnormalities-case-study-of-two-brothers
#17
E Wallach, E Bieth, A Sevely, C Cances
Fragile X syndrome is the most usual cause of hereditary intellectual deficiency. Typical symptoms combine intellectual deficiency, social anxiety, intense emotional vigilance, and a characteristic facial dysmorphy. This is subsequent to a complete mutation of the FMR1 gene, considering a semidominant transmission linked to the unstable X. The expansion of the CGG triplet greater than 200 units combined with a high methylation pattern lead to a transcriptional silence of the FMR1 gene, and the protein product, the FMRP, is not synthesized...
January 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28131162/resting-state-fmri-regional-homogeneity-correlates-with-cognition-measures-in-subcortical-vascular-cognitive-impairment
#18
Stefano Diciotti, Stefano Orsolini, Emilia Salvadori, Antonio Giorgio, Nicola Toschi, Stefano Ciulli, Andrea Ginestroni, Anna Poggesi, Nicola De Stefano, Leonardo Pantoni, Domenico Inzitari, Mario Mascalchi
BACKGROUND: The hyperintensity of cerebral white matter (WM) in T2-weighted MR images of elderly subjects due to small vessel disease (SVD) is associated with variable clinical features including mild cognitive impairment (MCI), also termed subcortical vascular cognitive impairment (SVCI). The latter is typically characterized by psychomotor slowing, attention deficits, and executive dysfunctions. We hypothesized that functional brain changes might be associated with these distinctive cognitive deficits in patients with SVCI...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130469/small-vessel-disease-burden-in-cerebral-amyloid-angiopathy-without-symptomatic-hemorrhage
#19
Gregoire Boulouis, Andreas Charidimou, Michael J Jessel, Li Xiong, Duangnapa Roongpiboonsopit, Panagiotis Fotiadis, Marco Pasi, Alison Ayres, M Emily Merrill, Kristin M Schwab, Jonathan Rosand, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
OBJECTIVE: Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease (SVD). Patients without intracerebral hemorrhage (ICH) typically present with transient focal neurologic episodes (TFNEs) or cognitive symptoms. We sought to determine if SVD lesion burden differed between patients with CAA first presenting with TFNEs vs cognitive symptoms. METHODS: A total of 647 patients presenting either to a stroke department (n = 205) or an outpatient memory clinic (n = 442) were screened for eligibility...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28128022/different-types-of-white-matter-hyperintensities-in-cadasil-insights-from-7-tesla-mri
#20
François De Guio, Alexandre Vignaud, Hugues Chabriat, Eric Jouvent
In Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), by contrast to sporadic cerebral small vessel disease related to age and hypertension, white matter hyperintensities (WMH) are frequently observed in the white matter of anterior temporal poles, external capsules, and superior frontal regions. Whether these WMH (specific WMH) differ from those observed in other white matter areas (nonspecific WMH) remains unknown. Twenty patients were scanned to compare specific and nonspecific WMH using high-resolution images and analyses of relaxation times (T1R: longitudinal relaxation time and T2*R: effective transversal relaxation time)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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