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white matter hyperintensity

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https://www.readbyqxmd.com/read/28815362/metric-to-quantify-white-matter-damage-on-brain-magnetic-resonance-images
#1
Maria Del C Valdés Hernández, Francesca M Chappell, Susana Muñoz Maniega, David Alexander Dickie, Natalie A Royle, Zoe Morris, Devasuda Anblagan, Eleni Sakka, Paul A Armitage, Mark E Bastin, Ian J Deary, Joanna M Wardlaw
PURPOSE: Quantitative assessment of white matter hyperintensities (WMH) on structural Magnetic Resonance Imaging (MRI) is challenging. It is important to harmonise results from different software tools considering not only the volume but also the signal intensity. Here we propose and evaluate a metric of white matter (WM) damage that addresses this need. METHODS: We obtained WMH and normal-appearing white matter (NAWM) volumes from brain structural MRI from community dwelling older individuals and stroke patients enrolled in three different studies, using two automatic methods followed by manual editing by two to four observers blind to each other...
August 16, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28814098/quantitative-and-qualitative-mri-evaluation-of-cerebral-small-vessel-disease-in-an-elderly-population-a-longitudinal-study
#2
Ruta Nylander, Markus Fahlström, Egill Rostrup, Joel Kullberg, Soheil Damangir, Håkan Ahlström, Lars Lind, Elna-Marie Larsson
Background Cerebral white matter hyperintensities (WMHs), lacunes, and microbleeds are seen on magnetic resonance imaging (MRI) in small vessel disease (SVD). Purpose To assess SVD on MRI and its evolution over five years in an elderly population and to investigate whether relative cerebral blood flow (rCBF) at baseline was related to the progression of white matter (WM) lesions. Material and Methods In a population-based study, 406 participants aged 75 years underwent morphological MRI of the brain and 252 of them again at age 80 years...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28810563/dystrophia-myotonica-type-1-presenting-with-dysarthria-a-case-report-and-literature-review
#3
Chunrong Li, Xiaoling Zhang, Chunkui Zhou, Lijun Zhu, Kangding Liu, Shaokuan Fang
Dystrophia myotonica (DM) type 1 is an autosomal dominant disorder, caused by a trinucleotide CTG repeat expansion in the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene (chromosome 19q13.3). The disorder affects different organ systems, including the skeletal muscles, ocular lens, lungs, heart and gastrointestinal tract, as well as the endocrine and central nervous systems. The skeletal muscles are most frequently involved, whereby the disorder manifests as myotonia, muscle weakness and amyotrophy...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810247/physical-inactivity-predicts-slow-gait-speed-in-an-elderly-multi-ethnic-cohort-study-the-northern-manhattan-study
#4
Joshua Z Willey, Yeseon P Moon, Erin R Kulick, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind
INTRODUCTION: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. METHODS: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test...
August 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28794252/white-matter-hyperintensity-reduction-and-outcomes-after-minor-stroke
#5
Joanna M Wardlaw, Francesca M Chappell, Maria Del Carmen Valdés Hernández, Stephen D J Makin, Julie Staals, Kirsten Shuler, Michael J Thrippleton, Paul A Armitage, Susana Muñoz-Maniega, Anna K Heye, Eleni Sakka, Martin S Dennis
OBJECTIVE: To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. METHODS: We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI. At 1 year, we assessed recurrent cerebrovascular events and dependency and repeated the MRI. We assessed change in WMH volume from baseline to 1 year (normalized to percent intracranial volume [ICV]) and associations with baseline variables, clinical outcomes, and imaging parameters using multivariable analysis of covariance, model of changes, and multinomial logistic regression...
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28794247/waxing-and-waning-of-white-matter-hyperintensities
#6
EDITORIAL
Frank-Erik de Leeuw, Fenwick Nichols
No abstract text is available yet for this article.
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28776906/association-of-subclinical-carotid-atherosclerosis-with-immediate-memory-and-other-cognitive-functions
#7
Lumine Matsumoto, Kazushi Suzuki, Yoshiko Mizuno, Yumiko Ohike, Atsuko Ozeki, Satoshi Ono, Mikio Takanashi, Daigo Sawaki, Toru Suzuki, Tsutomu Yamazaki, Shoji Tsuji, Atsushi Iwata
AIM: To clarify whether carotid atherosclerosis and its risk factors are associated with cognitive decline. METHODS: We evaluated 206 individuals who visited our center for health screening. We carried out physical examinations, blood tests, intima-media thickness (IMT) measurement by carotid ultrasonography, brain magnetic resonance imaging scanning and cognitive function assessments. A total of 30 individuals, who had significant cerebrovascular lesions detected in magnetic resonance imaging scans, were excluded...
August 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28775055/in-vivo-imaging-of-venous-side-cerebral-small-vessel-disease-in-older-adults-an-mri-method-at-7t
#8
C E Shaaban, H J Aizenstein, D R Jorgensen, R L MacCloud, N A Meckes, K I Erickson, N W Glynn, J Mettenburg, J Guralnik, A B Newman, T S Ibrahim, P J Laurienti, A N Vallejo, C Rosano
BACKGROUND AND PURPOSE: Traditional neuroimaging markers of small-vessel disease focus on late-stage changes. We aimed to adapt a method of venular assessment at 7T for use in older adults. We hypothesized that poorer venular morphologic characteristics would be related to other small-vessel disease neuroimaging markers and a higher prevalence of small-vessel disease-Alzheimer disease risk factors. MATERIALS AND METHODS: Venules were identified in periventricular ROIs on SWI and defined as tortuous or straight...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28769863/application-of-texture-analysis-to-study-small-vessel-disease-and-blood-brain-barrier-integrity
#9
Maria Del C Valdés Hernández, Victor González-Castro, Francesca M Chappell, Eleni Sakka, Stephen Makin, Paul A Armitage, William H Nailon, Joanna M Wardlaw
OBJECTIVES: We evaluate the alternative use of texture analysis for evaluating the role of blood-brain barrier (BBB) in small vessel disease (SVD). METHODS: We used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmented tissues, white matter hyperintensities (WMH) and applied validated visual scores. We measured textural features in all tissues pre- and post-contrast and used ANCOVA to evaluate the effect of SVD indicators on the pre-/post-contrast change, Kruskal-Wallis for significance between patient groups and linear mixed models for pre-/post-contrast variations in cerebrospinal fluid (CSF) with Fazekas scores...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28769784/cortical-surface-thickness-in-the-middle-aged-brain-with-white-matter-hyperintense-lesions
#10
Ying Zhuang, Xianjun Zeng, Bo Wang, Muhua Huang, Honghan Gong, Fuqing Zhou
Background and purpose: Previous voxel-based morphometry (VBM) studies have suggested that cortical atrophy is regionally distributed in middle-aged subjects with white matter hyperintense (WMH) lesions. However, few studies have assessed cortical thickness in middle-aged WMH subjects. In this study, we examined cortical thickness as well as cortical morphometry associated with the presence of WMH lesion load in middle-aged subjects. Participants and methods: Thirty-six middle-aged subjects with WMH lesions (WMH group) and without clinical cognitive impairment, and 34 demographically matched healthy control subjects (HCS group) participated in the study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28768849/brain-imaging-in-myotonic-dystrophy-type-1-a-systematic-review
#11
REVIEW
Kees Okkersen, Darren G Monckton, Nhu Le, Anil M Tuladhar, Joost Raaphorst, Baziel G M van Engelen
OBJECTIVE: To systematically review brain imaging studies in myotonic dystrophy type 1 (DM1). METHODS: We searched Embase (index period 1974-2016) and MEDLINE (index period 1946-2016) for studies in patients with DM1 using MRI, magnetic resonance spectroscopy (MRS), functional MRI (fMRI), CT, ultrasound, PET, or SPECT. From 81 studies, we extracted clinical characteristics, primary outcomes, clinical-genetic correlations, and information on potential risk of bias...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28765289/vascular-risk-factor-profiles-differ-between-magnetic-resonance-imaging-defined-subtypes-of-younger-onset-lacunar-stroke
#12
Loes C A Rutten-Jacobs, Hugh S Markus
BACKGROUND AND PURPOSE: Differing associations of vascular risk factors with lacunar infarct have been reported, which is likely because of diagnostic differences and possible heterogeneity in the pathogenesis underlying lacunar infarction. In a large magnetic resonance imaging-verified cohort of lacunar infarct patients, we investigated the risk factor profile of lacunar infarction and magnetic resonance imaging characteristics. METHODS: One thousand twenty-three patients with lacunar infarction (mean age, 56...
August 1, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28760515/mri-markers-of-neurodegenerative-and-neurovascular-changes-in-relation-to-postoperative-delirium-and-postoperative-cognitive-decline
#13
REVIEW
Ilse M J Kant, Jeroen de Bresser, Simone J T van Montfort, Arjen J C Slooter, Jeroen Hendrikse
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common in elderly patients. The aim of the present review was to explore the association of neurodegenerative and neurovascular changes with the occurrence of POD and POCD. Fifteen MRI studies were identified by combining multiple search terms for POD, POCD, and brain imaging. These studies described a total of 1,422 patients and were all observational in design. Neurodegenerative changes (global and regional brain volumes) did not show a consistent association with the occurrence of POD (four studies) or POCD (two studies)...
June 28, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28757483/association-of-blood-pressure-control-level-with-left-ventricular-morphology-and-function-and-with-subclinical-cerebrovascular-disease
#14
Koki Nakanishi, Zhezhen Jin, Shunichi Homma, Mitchell S V Elkind, Tatjana Rundek, Aylin Tugcu, Ralph L Sacco, Marco R Di Tullio
BACKGROUND: Left ventricular (LV) hypertrophy and subclinical cerebrovascular disease are early manifestations of cardiac and brain target organ damage caused by hypertension. This study aimed to investigate whether intensive office systolic blood pressure (SBP) control has beneficial effects on LV morphology and function and subclinical cerebrovascular disease in elderly patients with hypertension. METHODS AND RESULTS: We examined 420 patients treated for hypertension without history of heart failure and stroke from the CABL (Cardiovascular Abnormalities and Brain Lesions) study...
July 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28756941/peripheral-lipid-oxidative-stress-markers-are-related-to-vascular-risk-factors-and-subcortical-small-vessel-disease
#15
Walter Swardfager, Di Yu, Gustavo Scola, Hugo Cogo-Moreira, Parco Chan, Yi Zou, Nathan Herrmann, Krista L Lanctôt, Joel Ramirez, Fuqiang Gao, Mario Masellis, Richard H Swartz, Demetrios J Sahlas, Pak Cheung Chan, Carmen Ojeda-Lopez, Angela Milan-Tomas, Jacqueline A Pettersen, Ana C Andreazza, Sandra E Black
Subcortical white matter hyperintensities (WMH), presumed to indicate small vessel ischemic vascular disease, are found commonly in elderly individuals with and without Alzheimer's disease (AD). Oxidative stress may instigate or accelerate the development of vascular disease, and oxidative stress markers are elevated in AD. Here, we assess independent relationships between three serum lipid peroxidation markers (lipid hydroperoxides [LPH], 8-isoprostane, and 4-hydroxynonenal) and the presence of extensive subcortical WMH and/or AD...
July 11, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28754833/dolichoectasia-and-small-vessel-disease-in-young-patients-with-transient-ischemic-attack-and-stroke
#16
Vincent Thijs, Ulrike Grittner, Franz Fazekas, Dominick J H McCabe, Anne-Katrin Giese, Christof Kessler, Peter Martus, Bo Norrving, Erich Bernd Ringelstein, Reinhold Schmidt, Christian Tanislav, Jukka Putaala, Turgut Tatlisumak, Bettina von Sarnowski, Arndt Rolfs, Christian Enzinger
BACKGROUND AND PURPOSE: We evaluated whether basilar dolichoectasia is associated with markers of cerebral small vessel disease in younger transient ischemic attack and ischemic stroke patients. METHODS: We used data from the SIFAP1 study (Stroke in Young Fabry Patients), a large prospective, hospital-based, screening study for Fabry disease in young (<55 years) transient ischemic attack/stroke patients in whom detailed clinical data and brain MRI were obtained, and stroke subtyping with TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment) was performed...
July 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28754803/uric-acid-and-incident-dementia-over-12-years-of-follow-up-a-population-based-cohort-study
#17
Augustin Latourte, Aicha Soumaré, Thomas Bardin, Fernando Perez-Ruiz, Stéphanie Debette, Pascal Richette
OBJECTIVES: In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective. However, the relation between SUA and dementia remains debated. This study aimed to investigate the impact of SUA level on the incidence of dementia. METHODS: We assessed the longitudinal association between SUA level and incident dementia (Diagnostic and Statistical Manual of Mental Disorders Version IV (DSM-IV) criteria) in a large cohort of healthy older people from the community (Three-City Dijon cohort)...
July 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28747064/graph-lasso-based-test-for-evaluating-functional-brain-connectivity-in-sickle-cell-disease
#18
Julie Coloigner, Ronald Phlypo, Thomas D Coates, Nastasha Lepore, John C Wood
Sickle cell disease (SCD) is a vascular disorder that is often associated with recurrent ischemia-reperfusion injury, anemia, vasculopathy and strokes. These cerebral injuries are associated with neurological dysfunction, limiting the full developing potential of the patient. However, recent large studies of SCD have demonstrated that cognitive impairment occurs even in the absence of brain abnormalities on conventional magnetic resonance imaging (MRI). These observations support an emerging consensus that brain injury in SCD is diffuse and that conventional neuroimaging often underestimates the extent of injury...
July 26, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#19
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28729834/white-matter-hyperintensity-in-elderly-patients-with-diabetes-mellitus-is-associated-with-cognitive-impairment-functional-disability-and-a-high-glycoalbumin-glycohemoglobin-ratio
#20
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki
Aims: Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment of activities of daily living (ADL), the clinical relevance of WMH in elderly patients with diabetes mellitus (DM) is not still clear. The aim of this study was to examine whether WMH volume is associated with ADL and cognitive function and whether glucose control and glucose variability can affect WMH volume in these patients. Methods: This cross-sectional study investigated the associations of WMH with cognitive function and instrumental ADL (IADL), as well as metabolic and vascular risk factors in a total of 178 elderly patients with diabetes...
2017: Frontiers in Aging Neuroscience
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