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Emergency medicine administration

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https://www.readbyqxmd.com/read/28511730/simulation-in-canadian-postgraduate-emergency-medicine-training-a-national-survey
#1
Evan Russell, Andrew Koch Hall, Carly Hagel, Andrew Petrosoniak, Jeffrey Damon Dagnone, Daniel Howes
OBJECTIVES: Simulation-based education (SBE) is an important training strategy in emergency medicine (EM) postgraduate programs. This study sought to characterize the use of simulation in FRCPC-EM residency programs across Canada. METHODS: A national survey was administered to residents and knowledgeable program representatives (PRs) at all Canadian FRCPC-EM programs. Survey question themes included simulation program characteristics, the frequency of resident participation, the location and administration of SBE, institutional barriers, interprofessional involvement, content, assessment strategies, and attitudes about SBE...
May 17, 2017: CJEM
https://www.readbyqxmd.com/read/28509871/nutraceutical-value-of-citrus-flavanones-and-their-implications-in-cardiovascular-disease
#2
REVIEW
Lara Testai, Vincenzo Calderone
Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value...
May 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28497661/medication-related-osteonecrosis-of-the-jaw-risk-factors-in-patients-under-biphosphonate-versus-patients-under-antiresorptive-antiangiogenic-drugs
#3
Giulia Ghidini, Maddalena Manfredi, Ilaria Giovannacci, Giovanni Mergoni, Amin Sarraj, Maura Mureddu, Giovanna Giunta, Mauro Bonanini, Marco Meleti, Paolo Vescovi
BACKGROUND: Biphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is a potential side effect associated with the administration of bisphosphonates; the aim of this work is to highlight the possible epidemiological differences between two groups of patients affected by MRONJ treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, Italy, between January 2004 and June 2016. METHODS: Medical charts of 303 patients (214 Females and 89 Males, mean age 67y) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, between January 2004 and June 2016, were retrospectively analyzed...
May 10, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28494418/zingiber-officinale-and-6-gingerol-alleviate-liver-and-kidney-dysfunctions-and-oxidative-stress-induced-by-mercuric-chloride-in-male-rats-a-protective-approach
#4
Deepmala Joshi, Sunil Kumar Srivastav, Sateesh Belemkar, Vaibhav A Dixit
Mercury toxicity is an emerging problem in the world as its concentration is rising continuously due to increased industrial, medicinal and domestic uses. Exposure to mercury represents a serious challenge to humans and other living biomes. The aim of the present study was to assess the protective effect of natural products as Zingiber officinale extract and its active compound (6-gingerol) against mercuric chloride-induced hepatorenal toxicity and oxidative stress in male rats. Male Sprague-Dawley rats (150±10g, n=6 per group) were administered HgCl2 (12μmol/kg, ip; once only) the treatment of Zingiber officinale Rosc...
May 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28488967/purinergic-control-of-red-blood-cell-metabolism-novel-strategies-to-improve-red-cell-storage-quality
#5
REVIEW
Kaiqi Sun, Angelo D'alessandro, Yang Xia
Transfusion of stored blood is regarded as one of the great advances in modern medicine. However, during storage in the blood bank, red blood cells (RBCs) undergo a series of biochemical and biomechanical changes that affect cell morphology and physiology and potentially impair transfusion safety and efficacy. Despite reassuring evidence from clinical trials, it is universally accepted that the storage lesion(s) results in the altered physiology of long-stored RBCs and helps explain the rapid clearance of up to one-fourth of long-stored RBCs from the recipient's bloodstream at 24 hours after administration...
April 12, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28480761/topical-treatment-of-glaucoma-established-and-emerging-pharmacology
#6
Mark S Dikopf, Thasarat S Vajaranant, Deepak P Edward
Glaucoma is a collection of optic neuropathies consisting of retinal ganglion cell death and corresponding visual field loss. Glaucoma is the leading cause of irreversible vision loss worldwide and is forecasted to precipitously increase in prevalence in the coming decades. Current treatment options aim to lower intraocular pressure (IOP) via topical or oral therapy, laser treatment to the trabecular meshwork or ciliary body, and incisional surgery. Despite increasing use of trabecular laser therapy, topical therapy remains first-line in the treatment of most forms of glaucoma...
May 6, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28471351/repurposing-niclosamide-as-a-versatile-antimicrobial-surface-coating-against-device-associated-hospital-acquired-bacterial-infections
#7
Tinotenda Gwisai, Nisha Hollingsworth, Sarah Cowles, Nagendran Tharmalingam, Eleftherios Mylonakis, Beth Fuchs, Anita Shukla
Device-associated and hospital-acquired infections remain amongst the greatest challenges in regenerative medicine. Furthermore, the rapid emergence of antibiotic resistance and lack of new classes of antibiotics has made the treatment of these bacterial infections increasingly difficult. The repurposing of Food and Drug Administration (FDA) approved drugs for antimicrobial therapies is a powerful means of reducing the time and cost associated with drug discovery and development. In this work, niclosamide, a commercially available anthelmintic drug with recently identified antimicrobial properties, was found to prevent and combat existing biofilms of several relevant gram-positive bacteria, namely strains of Staphylococcus aureus, including methicillin resistant S...
May 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28465155/effect-of-liver-disease-on-hepatic-transporter-expression-and-function
#8
REVIEW
Nilay Thakkar, Jason R Slizgi, Kim L R Brouwer
Liver disease can alter the disposition of xenobiotics and endogenous substances. Regulatory agencies such as the Food and Drug Administration (FDA) and the European Medicines Evaluation Agency (EMEA) recommend, if possible, studying the effect of liver disease on drugs under development to guide specific dose recommendations in these patients. While extensive research has been conducted to characterize the effect of liver disease on drug-metabolizing enzymes, emerging data have implicated that the expression and/or function of hepatobiliary transport proteins also are altered in liver disease...
April 29, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28464937/seasonal-vaccination-against-malaria-a-potential-use-for-an-imperfect-malaria-vaccine
#9
REVIEW
Brian Greenwood, Alassane Dicko, Issaka Sagara, Issaka Zongo, Halidou Tinto, Matthew Cairns, Irene Kuepfer, Paul Milligan, Jean-Bosco Ouedraogo, Ogobara Doumbo, Daniel Chandramohan
In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria chemoprevention (SMC), which involves administration of a full course of malaria treatment to young children at monthly intervals during the high transmission season, is proving to be an effective malaria control measure in these areas. However, SMC does not provide complete protection and it is demanding to deliver for both families and healthcare givers...
May 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28462768/emergency-physician-disaster-deployment-issues-to-consider-and-a-model-policy
#10
Christopher A Kahn, Kristi L Koenig, Carl H Schultz
Disaster responders are frequently emergency physicians (EPs). Effective response is enhanced by the strong support of home institutions and clear policies for backfill of regular duties. A group of disaster medicine responders and researchers worked with an academic department of emergency medicine to create a policy that addresses concerns of deploying physicians, colleagues remaining at the home institution, and administrators. This article describes the process and content of this policy development work...
May 2, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28457072/the-dedicated-enough-doctor-the-limits-of-medical-altruism-in-the-21st-century
#11
Peter Gilbey, Mary C J Rudolf, Sivan Spitzer-Shohat, Anthony Luder
The unique characteristics of the next generation of medical professionals in Israel and the current model of physician employment in the country may pose a real threat to the high quality of both public clinical care and medical education in the near future, and to the continued flourishing of clinical research. According to the Israel Medical Association's general obligations for Israeli physicians, the doctor should place the patient's interests foremost in his or her mind, before any other issue. This has led many to believe that selflessness or altruism should be among a physician's core values...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28455163/sex-differences-in-outcomes-after-discharge-from-the-emergency-department-for-atrial-fibrillation-flutter
#12
Rhonda J Rosychuk, Brian R Holroyd, Xuechen Zhang, Brian H Rowe, Michelle M Graham
BACKGROUND: Atrial fibrillation and flutter (AFF) are the most common arrhythmias presenting to emergency departments (EDs). We examined sex differences in outcomes for patients with AFF discharged from the ED in Alberta, Canada. METHODS: ED presentations for AFF during 1999-2011 that ended in discharge were extracted from administrative databases for all Alberta residents (age ≥ 35 years). Multivariable models determined the effect of sex on the time to ED return for AFF, the first follow-up visit with a physician, the first follow-up visit with a specialist (cardiologist or internal medicine physician), and death...
April 17, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449321/a-review-of-associated-controversies-surrounding-glucocorticoid-use-in-veterinary-emergency-and-critical-care
#13
Maya A Aharon, Jennifer E Prittie, Kate Buriko
OBJECTIVE: To review the literature in human and veterinary medicine regarding the indications for, efficacy of, and controversies surrounding glucocorticoid (GC) administration in the emergency and critical care (ECC) setting, and to provide an overview of the most commonly used synthetic GC formulations. MEDICATIONS: Synthetic GCs vary in GC and mineralocorticoid potency, hypothalamic pituitary axis suppression, duration of action, route of administration, and clinical indication for use...
May 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28404519/proteasome-inhibitors-to-alleviate-aberrant-ikbkap-mrna-splicing-and-low-ikap-help1-synthesis-in-familial-dysautonomia
#14
Mylène Hervé, El Chérif Ibrahim
FD is a rare neurodegenerative disorder caused by a mutation of the IKBKAP gene, which induces low expression levels of the Elongator subunit IKAP/hELP1 protein. A rational strategy for FD treatment could be to identify drugs increasing IKAP/hELP1 expression levels by blocking protein degradation pathways such as the 26S proteasome. Proteasome inhibitors are promising molecules emerging in cancer treatment and could thus constitute an enticing pharmaceutical strategy for FD treatment. Therefore, we tested three proteasome inhibitors on FD human olfactory ecto-mesenchymal stem cells (hOE-MSCs): two approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), bortezomib and carfilzomib, as well as epoxomicin...
April 9, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28400291/unmet-clinical-needs-in-the-treatment-of-systemic-fungal-infections-the-role-of-amphotericin-b-and-drug-targeting
#15
Raquel Fernández-García, Esther de Pablo, María Paloma Ballesteros, Dolores R Serrano
Recently an increase in both the prevalence and incidence of invasive fungal infections have been reported. The number of fungal species that can cause systemic mycoses are higher and current antifungal therapies are still far from ideal. The emergence of antifungal resistances has a major clinical impact when using azoles and echinocandins leading to possible treatment failure and ultimately putting the patient's life at risk. Amphotericin B can play a key role in treating severe invasive mycoses as the incidence of antifungal resistance is very low combined with a high efficacy against a wide range of fungi...
April 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28398544/beliefs-about-a-complementary-and-alternative-therapy-based-chronic-pain-management-program-for-a-medicaid-population
#16
Elizabeth Donovan, Megan L Ranney, Emily J Patry, Michelle McKenzie, Janette Baird, Traci C Green
Objective.:  Rhode Island Medicaid offers high emergency department utilizers the opportunity to take part in the Chronic Pain Program, an integrated treatment approach that includes free complementary therapies (massage, chiropractic, and acupuncture). The aim of the current analysis was to understand beliefs about the Rhode Island Chronic Pain Program from the perspective of the patient receiving services, the provider delivering services, and the administrator implementing the program...
April 8, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28398072/the-reactive-species-interactome-evolutionary-emergence-biological-significance-and-opportunities-for-redox-metabolomics-and-personalized-medicine
#17
Miriam Margherita Cortese-Krott, Anne Koning, Gunter Georg Kuhnle, Peter Nagy, Christopher Bianco, Andreas Pasch, David A Wink, Jon Fukuto, Alan A Jackson, Harry van Goor, Kenneth R Olson, Martin Feelisch
SIGNIFICANCE: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not administration of antioxidants is ineffective, suggesting our current understanding of the underlying regulatory processes is incomplete. Recent Advances. Similar to reactive oxygen and nitrogen species (ROS, RNS), reactive sulfur species (RSS) are now emerging as important signaling molecules, targeting regulatory cysteine redox switches in proteins, affecting gene regulation, ion transport, intermediary metabolism and mitochondrial function...
April 11, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28394736/what-do-providers-want-to-know-about-opioid-prescribing-a-qualitative-analysis-of-their-questions
#18
Phoebe A Cushman, Jane M Liebschutz, Joseph G Hodgkin, Christopher W Shanahan, Julie L White, Ilana Hardesty, Daniel P Alford
BACKGROUND: In 2012, the US Food and Drug Administration (FDA) responded to the opioid crisis with a Risk Evaluation and Mitigation Strategy, requiring manufacturers of extended-release/long-acting opioids to fund continuing medical education based on the "FDA Blueprint for Prescriber Education." Topics in the Blueprint are "Assessing Patients for Treatment," "Initiating Therapy, Modifying Dosing, and Discontinuing Use," "Managing Therapy," "Counseling Patients and Caregivers about Safe Use," "General Drug Information," and "Specific Drug Information...
April 2017: Substance Abuse
https://www.readbyqxmd.com/read/28362380/production-and-administration-of-therapeutic-mesenchymal-stem-stromal-cell-msc-spheroids-primed-in-3-d-cultures-under-xeno-free-conditions
#19
Joni H Ylostalo, Nikolay Bazhanov, Arezoo Mohammadipoor, Thomas J Bartosh
Mesenchymal stem/stromal cells (MSCs) hold great promise in bioengineering and regenerative medicine. MSCs can be isolated from multiple adult tissues via their strong adherence to tissue culture plastic and then further expanded in vitro, most commonly using fetal bovine serum (FBS). Since FBS can cause MSCs to become immunogenic, its presence in MSC cultures limits both clinical and experimental applications of the cells. Therefore, studies employing chemically defined xeno-free (XF) media for MSC cultures are extremely valuable...
March 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28359835/reasons-for-non-initiation-and-non-completion-of-hpv-vaccine-among-english-and-spanish-speaking-parents-of-adolescent-girls-a-qualitative-study
#20
Karen Albright, Juliana Barnard, Sean O'Leary, Steven Lockhart, Andrea Jimenez-Zambrano, Shannon Stokley, Amanda Dempsey, Allison Kempe
OBJECTIVE: The Advisory Committee on Immunization Practices recommends routine human papillomavirus (HPV) vaccination for females aged 11-12 years, yet vaccination rates remain low. We conducted a qualitative study to understand English- and Spanish-speaking parents' reasons for non-initiation or non-completion of the HPV vaccine series for their daughters. METHODS: Parents of females aged 12-15 years who had not initiated or not completed the HPV vaccine series were identified through administrative data in two large urban safety net health care systems in Colorado...
March 27, 2017: Academic Pediatrics
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