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Vaccination splenectomy

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https://www.readbyqxmd.com/read/28410825/active-offer-of-vaccinations-during-hospitalization-improves-coverage-among-splenectomized-patients-an-italian-experience
#1
Maria Serena Gallone, Carmen Martino, Michele Quarto, Silvio Tafuri
In 2014, an Italian hospital implemented a protocol for pneumococcal, meningococcal, and Haemophilus influenzae type b vaccines offer to splenectomized patients during their hospitalization. After 1 year, coverage for recommended vaccinations increased from 5.7%-66.7% and the average time between splenectomy and vaccines administration decreased from 84.7-7.5 days.
April 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28342711/epidemiological-profile-and-vaccination-coverage-in-splenectomy-patients-in-a-health-area-of-murcia-1993-2012
#2
Yolanda Molina-Salas, Francisco José Romera-Guirado, Jaime Jesús Pérez-Martín, María Nieves Peregrín-González, David Góngora-Soria
OBJECTIVE: Splenectomy patients have a high risk of suffering severe infections, many of them preventable by vaccination. The aim of the study was to analyse the clinical epidemiological characteristics and vaccine coverage of these patients in Health Area III of the Region of Murcia. METHOD: A cross-sectional study was conducted on a population of patients that were splenectomised during the period 1993-2012, according to the Register of the Basic Minimum Data Set...
March 22, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28303214/evidence-based-management-and-controversies-in-blunt-splenic-trauma
#3
REVIEW
D C Olthof, C H van der Vlies, J C Goslings
PURPOSE OF REVIEW: The study aims to describe the evidence-based management and controversies in blunt splenic trauma. RECENT FINDINGS: A shift from operative management to non-operative management (NOM) has occurred over the past decades where NOM has now become the standard of care in haemodynamically stable patients with blunt splenic injury. Splenic artery embolisation (SAE) is generally believed to increase the success rate of NOM. Not all the available evidence is that optimistic about SAE however...
2017: Current Trauma Reports
https://www.readbyqxmd.com/read/28213046/splenectomy-as-a-destination-improving-quality-of-care-among-asplenic-veterans-through-a-travel-clinic
#4
Aaron P Mitchell, Joel C Boggan, Karen Lau, David L Simel
BACKGROUND: Asplenic patients are at risk for severe infections, but adherence to recommended preventive education and vaccination is poor. The goal of this study was to demonstrate that a targeted intervention can improve vaccination rates in a population of asplenic veterans. METHODS: Surgically asplenic patients actively receiving care in our health care system were identified via a database search. Patients were contacted via mailed letters and encouraged to attend an existing travel clinic with a new process designed for asplenic patients...
February 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28190612/-long-term-infectious-risks-after-splenectomy-a-retrospective-cohort-study-with-up-to-10-years-follow-up
#5
E Meriglier, M Puyade, M Carretier, F Roblot, P Roblot
INTRODUCTION: Although most infections occur within the first 2 years after splenectomy, the relatively short follow-up reported in many studies may underestimate the frequency of infections. The objective of the study was to determine the incidence of infective outcomes and factors associated with infection after splenectomy by studying a group of patients who underwent splenectomy over a 10-year period. METHODS: A retrospective and monocentric study of patients who underwent splenectomy between January 1st, 1997 and December 31st, 2004 in a French university hospital...
February 9, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28131440/-epidemiology-and-pharmacoepidemiology-of-immune-thrombocytopenia
#6
G Moulis, M Lapeyre-Mestre, D Adoue, L Sailler
During the last decade, the development of large clinical and population-based cohorts led to new findings in the epidemiology and the pharmacoepidemiology of immune thrombocytopenia (ITP). The incidence is estimated to 3-4 for 10(5) inhabitants/year, with a slight female predominance and peaks in children and patients after 60 years. The incidence rate is 9 for 10(5) inhabitants/year in males after 75 years. Variations across ethnic groups are discussed. In France, there is a North-South gradient and a peak of incidence during winter suggesting the role of viruses in ITP pathophysiology...
January 25, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27975073/postsplenectomy-prophylaxis-a-persistent-failure-to-meet-standard
#7
Alexander David Jones, Mashuk Khan, James Cheshire, Douglas Bowley
A retrospective case review of patients that underwent emergency splenectomy or splenic preservation from May 2003 to April 2014 was undertaken at a single center. The results highlight failures in administration of postsplenectomy vaccination for emergency splenectomy patients. In this study, we highlight methods to improve postsplenectomy care.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27851622/1988-pneumococcal-sepsis-in-itp-post-splenectomy-and-vaccination-due-to-coexisting-cvid
#8
Anusha Shanbhag, Oscar Llanos Ulloa, Nikhil Meena
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27818226/primary-care-of-the-blunt-splenic-injured-adult
#9
REVIEW
Brian K Yorkgitis
The spleen is the most commonly injured abdominal organ in blunt trauma. Immediate treatment is aimed at assessing for bleeding and abating it when it is severe. Methods for the management of blunt splenic injury-associated bleeding include observation, splenectomy, and splenic salvage procedures through splenorrhaphy or embolization. After blunt splenic injury, complications commonly occur, including bleeding, infection, thrombosis, and pneumonia. If a patient undergoes splenectomy, infections can be severe...
March 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/27648207/influenza-and-pneumococcal-vaccination-in-hematological-malignancies-a-systematic-review-of-efficacy-effectiveness-and-safety
#10
REVIEW
Giuseppe La Torre, Alice Mannocci, Vittoria Colamesta, Valeria D'Egidio, Cristina Sestili, Antonietta Spadea
BACKGROUND: The risk of getting influenza and pneumococcal disease is higher in cancer patients, and serum antibody levels tend to be lower in patients with hematological malignancy. OBJECTIVE: To assess flu and pneumococcal vaccinations efficacy, effectiveness, and safety in onco-hematological patients. METHODS: Two systematic reviews and possible meta-analysis were conducted to summarize the results of all primary study in the scientific literature about the flu and pneumococcal vaccine in onco-hematological patients...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27610052/the-sword-of-damocles-for-the-splenectomised-death-by-opsi
#11
Christian Georg Blumentrath, Nils Ewald, Jasmina Petridou, Uwe Werner, Barbara Hogan
The overwhelming post splenectomy infection (OPSI) in splenectomised patients is a rare but severe infection mostly caused by encapsulated bacteria. We analyse the case of a 65-year-old female patient who was presented with clinical and laboratory findings indicating gastroenteritis. Two years years before admission, the patient underwent a splenectomy for a two stage splenic rupture following resuscitation for pulmonary embolism. Immunisation of the patient was complete and timely. As a result of the unspecific clinical presentation, there was a delay in administration of antibiotics...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27590561/asplenic-patients-and-invasive-pneumococcal-disease-how-bad-is-it-these-days
#12
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
OBJECTIVES: Most are aware of pneumococcal infection as a complication of splenectomy and the increased risk of severe invasive pneumococcal disease (IPD) in asplenic patients. However little is known of the current status of this entity in a population with an active pneumococcal conjugate vaccine program for children. METHODS: All IPD cases reported from 2000 to 2014 in Northern Alberta, Canada were collected prospectively. Socio-demographic variables, clinical characteristics, and IPD-related outcomes were compared between patients with and without a spleen using the Student t-test, Chi-square test, or Fisher's exact test, as appropriate...
October 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27583208/fatal-purpura-fulminans-and-waterhouse-friderichsen-syndrome-from-fulminant-streptococcus-pneumoniae-sepsis-in-an-asplenic-young-adult
#13
Andrew J Hale, Mary LaSalvia, James E Kirby, Allison Kimball, Rachel Baden
Asplenic patients are at increased risk for sepsis and fulminant infection. Sepsis in these patients is typically secondary to encapsulated bacteria, with Streptococcus pneumoniae being the most frequent pathogen. Rare complications of severe sepsis include purpura fulminans and bilateral adrenal hemorrhage (Waterhouse-Friderichsen syndrome). We present the case of a 36-year-old woman, healthy except for splenectomy years prior for idiopathic thrombocytopenic purpura treatment, who presented with fever. Upon presentation to our hospital, three hours after symptoms onset, she had purpura fulminans and shock...
2016: IDCases
https://www.readbyqxmd.com/read/27320116/-two-cases-of-overwhelming-post-splenectomy-infection
#14
Yutaro Sasaki, Kazuyoshi Izumi, Yasuo Kawanishi
In this report, we describe two cases of overwhelming post-splenectomy infection (OPSI). The first case was in a 70-year-old man who received a splenectomy in 2012 due to pancytopenia induced by hepatic cirrhosis. He presented with fever and fatigue. A blood test and abdominal ultrasonography were performed. However, these examinations did not indicate any abnormal findings. He unexpectedly suffered from septic shock and acute renal failure the following day. Treatment consisted of mechanical ventilation, broad-spectrum antibiotics and continuous hemodiafiltration...
May 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27276370/common-variable-immunodeficiency-immune-thrombocytopenia-rituximab-and-splenectomy-important-considerations
#15
Ruta Arays, Sahil Goyal, Kim M Jordan
Common variable immunodeficiency (CVID) is readily considered in patients presenting with recurrent sino-pulmonary infections, however this disease has a broad range of clinical manifestations and diagnosis can be delayed by several years. We present the case of a 44-year-old postpartum female who presented with nausea, vomiting and abdominal distension. Four years prior, she was hospitalized for treatment of immune thrombocytopenia (ITP) with splenectomy and rituximab followed by two episodes of bacterial meningitis despite immunizations...
August 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27221131/a-case-report-of-bacteremia-manifesting-as-an-overwhelming-postsplenectomy-infection-due-to-streptococcus-pneumoniae-post-vaccination
#16
Kosuke Hirose, Hirohisa Okabe, Tomoharu Yoshizumi, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Koichi Kimura, Hideo Baba, Yoshihiko Maehara
A 62-year-old woman was admitted for acute epigastralgia and high-grade fever of over 39 °C. The patient had undergone splenectomy for idiopathic portal hypertension 1 year ago and vaccination against Streptococcus pneumoniae immediately post operation. She developed localized peritoneal irritation and abdominal distension. Her serum creatinine had increased to 1.5 mg/dL and procalcitonin was 12.5 ng/ml. Computed tomography of the abdomen revealed edematous large intestine and increased ascites. From these results, the patient was considered to have spontaneous bacterial peritonitis (SBP)...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27182228/surgical-outcome-of-spelenectomy-in-thalassemia-major-in-children
#17
Ikramullah Khan Akhtar, Muhammad Ashraf, Irum Uzma Khalid, Mukhtar Hussain
OBJECTIVE: To determine the surgical outcome of splenectomy in children with thalassemia major. METHODS: It is an observational and descriptive study conducted in Department of Paediatric Surgery in collaboration with hematology, radiology, anesthesia and paediatric intensive care department at The Children's Hospital and the Institute of Child Health, Multan during the period of September 2007 to September 2013. A total of 50 patients suffering from thalassemia major already diagnosed and under management reffered from haematology department for splenectomy were included in this study...
March 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27141317/recurrent-invasive-pneumococcal-disease-serotype-12f-in-a-vaccinated-splenectomized-patient
#18
Anne Katrine Blaabjerg, Anna Holst Schumacher, Bjørn Kantsø, Lena Hagelskjær Kristensen, Helga Schumacher
This is the first case report of recurrent invasive pneumococcal disease (IPD), specifically, due to serotype 12F. The patient described here was vaccinated with the 23-valent pneumococcal polysaccharide vaccine (PPV23) due to previous splenectomy, and an anti-pneumococcal IgG test concluded that she had responded sufficiently to vaccination. Still, she had a fulminate recurrent infection with PPV23 serotype 12F. We investigated the anti-pneumococcal IgG test, and it turned out that it is based on the geometric mean value of only 12 of the serotypes included in PPV23; 12F is none of them...
March 2016: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/27099328/vaccinations-in-asplenic-adults
#19
REVIEW
Rhonda J Hammerquist, Kimberly A Messerschmidt, April A Pottebaum, Thaddaus R Hellwig
PURPOSE: The recommended immunizations for adult asplenic patients are reviewed. SUMMARY: Patients without a spleen are at risk of developing overwhelming postsplenectomy infections due to encapsulated organisms, mainly pneumococcal, meningococcal, and Haemophilus influenzae type b (Hib). Due to the high mortality rates associated with these infections, vaccinations are recommended as a preventive measure. It is challenging to ensure optimal immunizations in these high-risk patients due to the number of recommended vaccines, the availability of multiple formulations, and the inability to administer specific formulations at the same time, as well as differences in subsequent vaccine administration schedules...
May 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/26973649/an-oral-salmonella-based-vaccine-inhibits-liver-metastases-by-promoting-tumor-specific-t-cell-mediated-immunity-in-celiac-and-portal-lymph-nodes-a-preclinical-study
#20
Alejandrina Vendrell, Claudia Mongini, María José Gravisaco, Andrea Canellada, Agustina Inés Tesone, Juan Carlos Goin, Claudia Inés Waldner
Primary tumor excision is one of the most widely used therapies of cancer. However, the risk of metastases development still exists following tumor resection. The liver is a common site of metastatic disease for numerous cancers. Breast cancer is one of the most frequent sources of metastases to the liver. The aim of this work was to evaluate the efficacy of the orally administered Salmonella Typhi vaccine strain CVD 915 on the development of liver metastases in a mouse model of breast cancer. To this end, one group of BALB/c mice was orogastrically immunized with CVD 915, while another received PBS as a control...
2016: Frontiers in Immunology
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