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Bin Liang, Yongbao Li, Wei Ran, Bin Guo, Xuang Xu, Bo Liu, Jiafeng Li, Qiuwen Wu, Fugen Zhou
With robot-controlled linac positioning, the robotic radiotherapy system such as CyberKnife significantly increases the freedom in radiation beam placement, but also imposes more challenges on treatment plan optimization. The resampling mechanism in vendor supplied treatment planning system (MultiPlan) could not fully explore the increased beam direction search space. Besides, a sparse treatment plan (using fewer beams) is desired to improve the treatment efficiency. This study proposes a singular value decomposition linear programming (SVDLP) optimization technique for circular collimator based robotic radiotherapy...
November 17, 2017: Physics in Medicine and Biology
S Lévy, S Chapet, N Scher, K Debbi, A Ruffier, G Bernadou, Y Pointreau, G Calais
PURPOSE: To search for factors correlated with relapse-free survival following stereotactic reirradiation in patients with recurrent glioma following radiochemotherapy and evaluate tolerance to this treatment. PATIENTS AND METHODS: Initial radiotherapy was given according to the protocol of Stupp and al. Reirradiation was performed using the CyberKnife(®) system. Patients could have had surgical resection initially and at the time of recurrence. We analysed 13 patients treated between July 2010 and September 2014...
November 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Dominik Henzen, Daniel Schmidhalter, Claudia Christina Zanella, Werner Volken, Paul-Henry Mackeprang, Marco Malthaner, Michael Karl Fix, Peter Manser
Compared to a conventional linear accelerator, the Cyberknife (CK) is a unique system with respect to radiation protection shielding and the variety and number of non-coplanar beams are two key components regarding this aspect. In this work, a framework to assess the direction distribution and modulation factor (MF) of clinically applied treatment beams of a CyberKnife M6 is developed. Database filtering options allow studying the influence of different parameters such as collimator types, treatment sites or different bunker sizes...
November 10, 2017: Journal of Applied Clinical Medical Physics
Douglas Blaty, Michael Malos, Thomas Palmrose, Stephen McGirr
BACKGROUND: The purpose of this case report is to present a rare finding of an intradural extramedullary hemangioblastoma of the cauda equina, with literature review. Spinal hemangioblastomas account for 1-5% of all spinal cord tumors. While spinal hemangioblastomas are rare, it is exceedingly rare to have a case of intradural extramedullary hemangioblastoma of the spine, especially in isolation without von-Hippel-Lindau syndrome. Only 20 previous cases have been reported. CASE DESCRIPTION: An 82-year-old male presented with MRI evidence of an intradural mass at the L4 spinal level...
October 28, 2017: World Neurosurgery
Thomas Feutren, Andres Huertas, Julia Salleron, René Anxionnat, Serge Bracard, Olivier Klein, Didier Peiffert, Valérie Bernier-Chastagner
Cerebral arteriovenous malformations (AVMs) are rare vascular lesions potentially responsible for substantial neurological morbidity and mortality. Over the past four decades, radiosurgery has become a valid therapeutic option for many patients with small intracranial AVMs, but reports describing the use of robotic stereotactic radiosurgery (SRS) are rare. The purposes of this study are to describe the efficacy and toxicity of robotic SRS for AVMs and to review the literature. The reports of 48 consecutive patients treated with SRS were reviewed...
November 5, 2017: Neurosurgical Review
Qianyi Xu, Jiajin Fan, Jimm Grimm, Tamara LaCouture, Sucha Asbell, Joo Han Park, Gregory Kubicek
PURPOSE: There is no consensus on the optimal prescription isodose line (IDL) in CyberKnife (CK) SRS. We designed a strategy to search for optimal CK plans at different levels of IDLs and investigated the dosimetric impact on the quality of CK plans. METHODS AND MATERIALS: The retrospective study consisted of 13 CK patients with 16 brain tumors. The mean volume and size of the tumors was 9.7±10.4 cc and 30.3±10.9 mm, respectively. Four shells were created at distances of 2-3 mm to 60 mm from the target...
October 24, 2017: Medical Physics
Yubo Wang, Sivanagaraja Tatinati, Liyu Huang, Kim Jeong Hong, Ghufran Shafiq, Kalyana C Veluvolu, Andy W H Khong
Extracranial robotic radiotherapy employs external markers and a correlation model to trace the tumor motion caused by the respiration. The real-time tracking of tumor motion however requires a prediction model to compensate the latencies induced by the software (image data acquisition and processing) and hardware (mechanical and kinematic) limitations of the treatment system. A new prediction algorithm based on local receptive fields extreme learning machines (pLRF-ELM) is proposed for respiratory motion prediction...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Eric Jessie Christiansen, Bryan Richard Muir, Jason Belec, Eric J Vandervoort
A formalism has been proposed for small and non-standard photon fields in which k<sup>fclin, fmsr</sup> <sub>Qclin, Qmsr</sub> correction factors are used to correct dosimeter response in small fields (static or composite) relative to that in a larger machine-specific reference (MSR) field. For composite fields, a plan-class specific reference (PCSR) field can also be defined, serving as an intermediate calibration field between the MSR and clinical fields within a certain plan-class...
October 23, 2017: Physics in Medicine and Biology
Yoshihiko Manabe, Taro Murai, Hiroyuki Ogino, Takeshi Tamura, Michio Iwabuchi, Yoshimasa Mori, Hiromitsu Iwata, Hirochika Suzuki, Yuta Shibamoto
Definitive radiotherapy is an important alternative treatment for meningioma patients who are inoperable or refuse surgery. We evaluated the efficacy and toxicity of CyberKnife-based stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (hSRT) as first-line treatments for intracranial meningiomas that were diagnosed using magnetic resonance imaging (MRI) and/or computed tomography (CT). Between February 2005 and September 2015, 41 patients with intracranial meningiomas were treated with CyberKnife-based SRS or hSRT...
October 12, 2017: Neurologia Medico-chirurgica
Yangsen Cao, Xiaofei Zhu, Yu Zhang, Chunshan Yu, Yongming Liu, Yongjian Sun, Zhitao Dai, Xueling Guo, Xiaoping Ju, Huojun Zhang
To provide a modified formula consistent with the Monte Carlo (MC) algorithm for dose calculations during stereotactic ablative body radiotherapy for non-small cell lung cancer. Seventy CyberKnife treatment plans were calculated and analyzed by MC and ray-tracing (RT) algorithms, separately. Parameters of treatment plans were compared, and those associated with differences of dose distributions were analyzed to establish a modified formula. Gross tumor volume and tumor tracking volume (TTV) were defined as the evident disease on the sequences of the window width and level of the lung and the mediastinum...
October 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Masaki Nakamura, Hideki Nishimura, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryo Nishikawa, Ryohei Sasaki
The treatment of brainstem metastases remains a challenge as the brainstem itself is considered a neurological organ at risk. We aimed to investigate the efficacy and safety of CyberKnife hypofractionated stereotactic radiotherapy (HFSRT) for brainstem metastases, and to examine the balance between efficacy and safety for the management of neurological symptoms. A total of 26 lesions [pons (n = 18), medulla (n = 4) and midbrain (n = 4)] in 20 patients treated with CyberKnife hypofractionated stereotactic radiotherapy were retrospectively analyzed...
August 10, 2017: Journal of Radiation Research
Nobuyasu Awano, Soichiro Ikushima, Takehiro Izumo, Mari Tone, Kensuke Fukuda, Shingo Miyamoto, Yuan Bae, Toshio Kumasaka, Yuriko Terada, Yoshiaki Furuhata, Ryutaro Nomura, Kengo Sato
Background: CyberKnife® (CK) is a new, advanced radiotherapy technique. This study aimed to evaluate its efficacy and toxicity in Japanese patients with early-stage primary lung tumor who were medically unfit and inoperable. Methods: This retrospective study investigated patients who received CK treatment for medically inoperable Stage І primary lung tumor at the Japanese Red Cross Medical Center between June 2011 and September 2016. Each patient received a total of 36-48 Gy (median, 43 Gy) administered by CK in 4-5 fractions...
October 1, 2017: Japanese Journal of Clinical Oncology
Feng Xu, Hailiang Tang, Ji Xiong, Xiaoxia Liu
BACKGROUND: Primary moyamoya disease associated with skull base tumors has been rarely reported in the literature. Surgical treatment can be complicated due to the compensatory collateral circulation through meningeal and leptomeningeal anastomosis. The standard frontotemporal craniotomy may interrupt critical transdural anastomoses. CASE DESCRIPTION: We reported a case of primary moyamoya disease coexisting with tuberculum sellae meningioma and left cavernous sinus hemangioma...
September 25, 2017: World Neurosurgery
E Cantone, V Borzillo, A M Di Lullo, L Marano, E Guadagno, G Mansueto, R Di Franco, F Cammarota, L Catalano, P Muto, M Iengo
Sino-nasal solitary extramedullary plasmacytoma (EMP) is a rare neoplasm with unpredictable progression to multiple myeloma. To improve the precision of irradiation delivery, preserving the healthy surrounding tissue and critical structures we used a CyberKnife® for the treatment of sinonasal solitary extramedullary plasmacytoma. We present the first case of sinonasal-EMP treated with CyberKnife®-stereotactic radiotherapy (SRT) with a complete remission without adverse events. Based on the post-therapeutic results and healthy tissue preservation, we believe that CyberKnife®-SRT represents a good therapeutic option for the treatment of sinonasal-EMP...
July 2017: Journal of Biological Regulators and Homeostatic Agents
Elena De Martin, Dunja Duran, Francesco Ghielmetti, Elisa Visani, Domenico Aquino, Marcello Marchetti, Davide Rossi Sebastiano, Davide Cusumano, Maria Grazia Bruzzone, Ferruccio Panzica, Laura Fariselli
OBJECTIVE: Magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) provide non-invasive localization of eloquent brain areas for pre-surgical planning. The aim of this study is the integration of MEG and fMRI maps into a CyberKnife (CK) system to optimize dose planning. METHODS: Four patients with brain metastases in the motor area underwent functional imaging study of the hand motor cortex prior radiosurgery. MEG data were acquired during a visually cued hand motor-task...
September 20, 2017: World Neurosurgery
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
Xin Zhen, Bo Zhao, Zhuoyu Wang, Robert Timmerman, Ann Spangler, Nathan Kim, Asal Rahimi, Xuejun Gu
BACKGROUND: Recently developed stereotactic partial breast irradiation (S-PBI) allows delivery of a high biologically potent dose to the target while sparing adjacent critical organs and normal tissue. With S-PBI tumoricidal doses, accurate and precise dose delivery is critical to achieve high treatment quality. This study is to investigate both rigid and non-rigid components of target geometric error and their corresponding margins in S-PBI and identify correlated clinical factors. METHODS: Forty-three early-stage breast cancer patients with implanted gold fiducial markers were enrolled in the study...
September 11, 2017: Radiation Oncology
Cuauhtemoc de la Peña, Jorge H Guajardo, Maria F Gonzalez, Miguel A Hinojosa, Erick Cardona
Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body...
November 2017: Reports of Practical Oncology and Radiotherapy
Zhi-Yong Yang, Yu Chang, Hong-Yuan Liu, Gang Liu, Qin Li
The objective of this study is to quantify the clinical accuracy of the Cyberknife Xsight Lung Tracking System (XLTS) in our center and calculate the PTV margin of XLTS treated lung tumors. Data from the treatment log files of 22 lung cancer patients treated with the CyberKnife XLTS were analyzed and the PTV margin was calculated. Segmentation, deformation, correlation, prediction and targeting errors were calculated from the log files of XLTS treatments. Two different methods were used to calculate anisotropic treatment margin...
September 7, 2017: Scientific Reports
Luca Mattei, Francesco Prada, Marcello Marchetti, Paola Gaviani, Francesco DiMeco
Differentiating radionecrosis from tumour recurrence is a major issue in neuro-oncology. Conventional imaging is far from being validated as an alternative to histological assessment. We report the case of a patient operated on for suspected recurrence of brain metastasis 9 months after cyberknife radiosurgery. While magnetic resonance imaging showed strong enhancement of the lesion, intraoperative contrast-enhanced ultrasonography (CEUS) surprisingly did not-different from what is expected for brain metastases...
September 5, 2017: Acta Neurochirurgica
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