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CyberKnife

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https://www.readbyqxmd.com/read/27920555/effect-of-cyberknife-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-on-hepatic-toxicity
#1
Ping Liang, Cheng Huang, Shi-Xiong Liang, Ye-Fei Li, Shang-Xiao Huang, Zu-Ping Lian, Jian-Min Liu, Yang Tang, Hai-Jie Lu
OBJECTIVE: To evaluate the safety of CyberKnife stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and identify the treatment-related risk factors of hepatic toxicity. MATERIALS AND METHODS: One hundred and four HCC patients treated with CyberKnife SBRT were included in this study between August 2009 and December 2012. The average dose of prescribed radiation was 42.81±4.78 Gy (28-55 Gy) with the average fraction size of 8-16 Gy to the planning target volume...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27914096/successful-treatment-of-multiple-in-transit-melanomas-on-the-leg-with-intensity-modulated-radiotherapy-and-immune-checkpoint-inhibitors-report-of-two-cases
#2
Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Takanori Hidaka, Yota Sato, Kayo Tanita, Hisayuki Tono, Akira Tsukada, Akira Hashimoto, Setsuya Aiba
Because the efficacy rates of monotherapy with immune checkpoint inhibitors such as nivolumab or ipilimumab are not sufficient, to enhance the antitumor effects of these reagents is of great interest among dermato-oncologists. In this report, we describe two cases of multiple in-transit metastatic melanomas on the leg successfully treated with intensity-modulated radiotherapy (IMRT) using a CyberKnife in combination with ipilimumab or nivolumab. Our cases suggested that IMRT could enhance the antitumor effects of immune checkpoint inhibitors in patients with multiple in-transit melanomas...
December 3, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27909037/safety-and-efficacy-of-stereotactic-body-radiation-therapy-combined-with-s-1-simultaneously-followed-by-sequential-s-1-as-an-initial-treatment-for-locally-advanced-pancreatic-cancer-silapanc-trial-study-design-and-rationale-of-a-phase-ii-clinical-trial
#3
Xiaofei Zhu, Xiaoping Ju, Fei Cao, Fang Fang, Shuiwang Qing, Yuxin Shen, Zhen Jia, Yangsen Cao, Huojun Zhang
INTRODUCTION: Upfront surgeries are not beneficial to most patients with pancreatic cancer. Therefore, more emphasis has been placed chemoradiotherapy in locally advanced pancreatic cancer recently. Gemcitabine-based regimens or FOLFIRINOX (a chemotherapy regimen including leucovorin, 5-FU, irinotecan, oxaliplatin) has been proven as a standard chemotherapy in pancreatic cancer. However, severe toxicities may prevent the completion of chemotherapy. S-1 has showed better objective response rates, similar overall survival rates and progression-free survival rates compared with gemcitabine, revealing that S-1 may be a potential candidate in treating pancreatic cancer, especially for patients refractory to gemcitabine...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27903198/dosimetric-characterization-of-hypofractionated-gamma-knife-radiosurgery-of-large-or-complex-brain-tumors-versus-linear-accelerator-based-treatments
#4
Peng Dong, Angélica Pérez-Andújar, Dilini Pinnaduwage, Steve Braunstein, Philip Theodosopoulos, Michael McDermott, Penny Sneed, Lijun Ma
OBJECTIVE Noninvasive Gamma Knife (GK) platforms, such as the relocatable frame and on-board imaging, have enabled hypofractionated GK radiosurgery of large or complex brain lesions. This study aimed to characterize the dosimetric quality of such treatments against linear accelerator-based delivery systems that include the CyberKnife (CK) and volumetric modulated arc therapy (VMAT). METHODS Ten patients treated with VMAT at the authors' institution for large brain tumors (> 3 cm in maximum diameter) were selected for the study...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27897235/stereotactic-body-radiation-therapy-induces-fast-tumor-control-and-symptom-relief-in-patients-with-iliac-lymph-node-metastasis
#5
Zhongqiu Wang, Jing Wang, Hongqing Zhuang, Ping Wang, Zhiyong Yuan
The CyberKnife is a robotic stereotactic body radiotherapy (SBRT) system which has shown promising results for many malignances with good efficacy and low toxicity. This study aims to evaluate the response and local control (LC) obtained with CyberKnife in the management of iliac lymph node metastases (ILNM). Twenty-two patients with 27 ILNM were treated by CyberKnife from May 2010 to May 2016. Median follow-up time was 33 months (8-97). The complete response, partial response, stable disease and progression disease rates were 37...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27875568/gated-volumetric-modulated-arc-therapy-vs-tumor-tracking-cyberknife-radiotherapy-as-stereotactic-body-radiotherapy-for-hepatocellular-carcinoma-a-dosimetric-comparison-study-focused-on-the-impact-of-respiratory-motion-managements
#6
KyoungJun Yoon, Jungwon Kwak, Byungchul Cho, Jin-Hong Park, Sang Min Yoon, Sang-Wook Lee, Jong Hoon Kim
PURPOSE: To assess the potential dosimetric benefits associated with the CyberKnife (CK) tumor tracking capability, wherein an extra margin for respiratory tumor motion is not required, when compared to respiratory-gated volumetric-modulated arc therapy (VMAT) for hepatocellular carcinoma (HCC). METHODS: Twenty-nine HCC patients previously treated with double-arc VMAT were enrolled. In each VMAT plan, the individual internal target volume (ITV) margin around the tumor was determined by measuring its motion over 30-70% of respiratory phases using four-dimensional computed tomography, followed by a 5-mm isotropic margin for the planning target volume (PTV)...
2016: PloS One
https://www.readbyqxmd.com/read/27811201/a-robust-measurement-point-for-dose-verification-in-delivery-quality-assurance-for-a-robotic-radiosurgery-system
#7
Keita Kurosu, Iori Sumida, Hiroya Shiomi, Hirokazu Mizuno, Hiroko Yamaguchi, Hirofumi Okubo, Keisuke Tamari, Yuji Seo, Osamu Suzuki, Seiichi Ota, Shinichi Inoue, Kazuhiko Ogawa
In this CyberKnife® dose verification study, we investigated the effectiveness of the novel potential error (PE) concept when applied to the determination of a robust measurement point for targeting errors. PE was calculated by dividing the differences between the maximum increases and decreases in dose distributions by the original distribution after obtaining the former by shifting the source-to-axis and off-axis distances of each beam by ±1.0 mm. Thus, PE values and measurement point dose heterogeneity were analyzed in 48 patients who underwent CyberKnife radiotherapy...
November 3, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27805837/dosimetric-factors-predicting-radiation-pneumonitis-after-cyberknife-stereotactic-body-radiotherapy-for-peripheral-lung-cancer
#8
Masaki Nakamura, Hideki Nishimura, Masao Nakayama, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryohei Sasaki
OBJECTIVE: The aims of this study were to investigate the frequency of symptomatic radiation pneumonitis (RP) after CyberKnife lung stereotactic body radiotherapy (SBRT) and to evaluate predictive factors of symptomatic RP. METHODS: 56 patients with peripheral non-small-cell lung cancer were treated using the CyberKnife(®) VSI(™) System (Accuracy Inc., Sunnyvale, CA) between May 2013 and September 2015. Total radiation doses ranged from 48 to 56 Gy, as delivered in four equal fractions...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27798922/comparison-of-re-irradiation-outcomes-for-charged-particle-radiotherapy-and-robotic-stereotactic-radiotherapy-using-cyberknife-for-recurrent-head-and-neck-cancers-a-multi-institutional-matched-cohort-analysis
#9
Hideya Yamazaki, Yusuke Demizu, Tomoaki Okimoto, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Ken Yoshida, Tadayuki Kotsuma, Yasuo Yoshioka
AIM: To compare survival outcomes for charged particle radiotherapy (CP) and stereotactic body radiotherapy using CyberKnife (CK) in patients who had undergone re-irradiation for head and neck cancers. PATIENTS AND METHODS: We conducted a retrospective multi-institutional matched-cohort analysis on 25 patients treated with CP and 25 matched patients treated with CK according to three prognostic factors (nasopharyngeal cancer or not, interval between initial radiotherapy and re-irradiation, and planning target volume)...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27793529/-intraprostatic-fiducials-in-stereotactic-radiotherapy-for-prostate-cancer
#10
A Cordoba, D Pasquier, P Nickers, T Lacornerie, É Lartigau
PURPOSE: Image-guided radiotherapy for prostate cancer is widely used in radiotherapy departments. Intraprostatic gold fiducial markers are used to visualize prostate position and motion before and during treatment. The aim of this report is to describe our experience of implanting intraprostatic fiducial markers under local anesthesia before hypofractionated stereotactic radiotherapy for prostate cancer and to assess its tolerance and reproducibility. PATIENTS AND METHODS: Over a 6 and a half year period, 226 patients with prostate cancer received a stereotactic radiotherapy using the CyberKnife(®) system (Accuray) in our institution...
December 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27782698/a-pencil-beam-dose-calculation-model-for-cyberknife-system
#11
Bin Liang, Yongbao Li, Bo Liu, Fugen Zhou, Shouping Xu, Qiuwen Wu
PURPOSE: CyberKnife system is initially equipped with fixed circular cones for stereotactic radiosurgery. Two dose calculation algorithms, Ray-Tracing and Monte Carlo, are available in the supplied treatment planning system. A multileaf collimator system was recently introduced in the latest generation of system, capable of arbitrarily shaped treatment field. The purpose of this study is to develop a model based dose calculation algorithm to better handle the lateral scatter in an irregularly shaped small field for the CyberKnife system...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27774363/extracranial-facial-nerve-schwannoma-treated-by-hypo-fractionated-cyberknife-radiosurgery
#12
Ayaka Sasaki, Shinichiro Miyazaki, Tomokatsu Hori
Facial nerve schwannoma is a rare intracranial tumor. Treatment for this benign tumor has been controversial. Here, we report a case of extracranial facial nerve schwannoma treated successfully by hypo-fractionated CyberKnife (Accuray, Sunnyvale, CA) radiosurgery and discuss the efficacy of this treatment. A 34-year-old female noticed a swelling in her right mastoid process. The lesion enlarged over a seven-month period, and she experienced facial spasm on the right side. She was diagnosed with a facial schwannoma via a magnetic resonance imaging (MRI) scan of the head and neck and was told to wait until the facial nerve palsy subsides...
September 21, 2016: Curēus
https://www.readbyqxmd.com/read/27729088/target-delineation-and-optimal-radiosurgical-dose-for-pituitary-tumors
#13
Giuseppe Minniti, Mattia Falchetto Osti, Maximillian Niyazi
Stereotactic radiosurgery (SRS) delivered as either single-fraction or multi-fraction SRS (2-5 fractions) is frequently employed in patients with residual or recurrent pituitary adenoma. The most common delivery systems used for SRS include the cobalt-60 system Gamma Knife, the CyberKnife (CK) robotic radiosurgery system, or a modified conventional radiotherapy machine (linear accelerator, LINAC). Tumor control and normalization of hormone hypersecretion have been reported in 75-100 % and 25-80 % of patients, respectively...
October 11, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27716876/vestibular-schwannomas-treated-with-cyberknife%C3%A2-clinical-outcomes
#14
Raphaël Jumeau, Pierre-Yves Bondiau, Cécile Parietti-Winkler, Julia Salleron, Thierry Civit, Didier Peiffert, Valérie Bernier-Chastagner
PURPOSE: Fractionated stereotactic radiotherapy (FSR) is a recognized treatment for vestibular schwannomas (VS). This study's aim is to present clinical outcomes and local control (LC) results for patients with VS treated with FSR using the Cyberknife® (CK) in 2 French cancer centers. METHODS: Patients treated with FSR for VS between 2007 and 2012 were retrospectively analyzed. Local control was determined using follow-up MRI. The hearing preservation (HP) rate was determined by analyzing pretreatment and posttreatment audiograms...
September 22, 2016: Tumori
https://www.readbyqxmd.com/read/27690660/stereotactic-robot-assisted-mri-guided-laser-thermal-ablation-of-radiation-necrosis-in-the-posterior-cranial-fossa-technical-note
#15
Alvin Y Chan, Diem Kieu T Tran, Amandip S Gill, Frank P K Hsu, Sumeet Vadera
Laser interstitial thermal therapy (LITT) is a minimally invasive procedure used to treat a variety of intracranial lesions. Utilization of robotic assistance with stereotactic procedures has gained attention due to potential for advantages over conventional techniques. The authors report the first case in which robot-assisted MRI-guided LITT was used to treat radiation necrosis in the posterior fossa, specifically within the cerebellar peduncle. The use of a stereotactic robot allowed the surgeon to perform LITT using a trajectory that would be extremely difficult with conventional arc-based techniques...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27685124/dosimetric-comparison-between-cone-iris-based-and-incise-mlc-based-cyberknife-plans-for-single-and-multiple-brain-metastases
#16
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27660737/late-gadolinium-enhancement-cardiac-magnetic-resonance-imaging-post-robotic-radiosurgical-pulmonary-vein-isolation-rrpvi-first-case-in-the-world
#17
Edgar Monroy, Jose Azpiri, Cuauhtémoc De La Peña, Carlos Cardona, Miguel Hinojosa, Rafael Zamarripa, Jose Assad
Pulmonary vein isolation using robotic radiosurgery system CyberKnife is a new non-invasive treatment of atrial fibrillation, currently in clinical phase. Robotic radiosurgical pulmonary vein isolation (RRPVI) uses stereotactic, non-invasive (painless) pinpoint radiation energy delivery to a small, precise area to accomplish ablation. The purpose of this report is to describe the finding of an increase in the enhancement of the left atrium demonstrated with the use of cardiac magnetic resonance imaging using late gadolinium enhancement (LGE-CMR) as a result of RRPVI in the first case in the world in humans using CyberKnife as a treatment for paroxysmal atrial fibrillation (PAF)...
2016: Curēus
https://www.readbyqxmd.com/read/27659008/clinical-implementation-of-a-monte-carlo-based-treatment-plan-qa-platform-for-validation-of-cyberknife-and-tomotherapy-treatments
#18
N Reynaert, B Demol, M Charoy, S Bouchoucha, F Crop, A Wagner, T Lacornerie, F Dubus, E Rault, P Comte, R Cayez, C Boydev, D Pasquier, X Mirabel, E Lartigau, T Sarrazin
PURPOSE: The main focus of the current paper is the clinical implementation of a Monte Carlo based platform for treatment plan validation for Tomotherapy and Cyberknife, without adding additional tasks to the dosimetry department. METHODS: The Monte Carlo platform consists of C++ classes for the actual functionality and a web based GUI that allows accessing the system using a web browser. Calculations are based on BEAMnrc/DOSXYZnrc and/or GATE and are performed automatically after exporting the dicom data from the treatment planning system...
September 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27631875/extreme-hypofractionation-for-early-prostate-cancer-biology-meets-technology
#19
Berardino De Bari, Stefano Arcangeli, Delia Ciardo, Rosario Mazzola, Filippo Alongi, Elvio G Russi, Riccardo Santoni, Stefano M Magrini, Barbara A Jereczek-Fossa
The aim of this review is to present the available radiobiological, technical and clinical data about extreme hypofractionation in primary prostate cancer radiotherapy. The interest in this technique is based on the favourable radiobiological characteristics of prostate cancer and supported by advantageous logistic aspects deriving from short overall treatment time. The clinical validity of short-term treatment schedule is proven by a body of non-randomised studies, using both isocentric (LINAC-based) or non-isocentric (CyberKnife(®)-based) stereotactic body irradiation techniques...
August 29, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27570715/stereotactic-arrhythmia-radioablation-star-of-ventricular-tachycardia-a-treatment-planning-study
#20
Lei Wang, Benjamin Fahimian, Scott G Soltys, Paul Zei, Anthony Lo, Edward A Gardner, Patrick J Maguire, Billy W Loo
PURPOSE: The first stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia (VT) was delivered at Stanford on a robotic radiosurgery system (CyberKnife® G4) in 2012. The results warranted further investigation of this treatment. Here we compare dosimetrically three possible treatment delivery platforms for STAR. METHODS: The anatomy and target volume of the first treated patient were used for this study. A dose of 25 Gy in one fraction was prescribed to the planning target volume (PTV)...
2016: Curēus
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