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CyberKnife

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https://www.readbyqxmd.com/read/28716071/primary-solitary-plasmacytoma-of-the-liver-successful-treatment-with-fractionated-stereotactic-radiotherapy-cyberknife%C3%A2-a-case-report
#1
Thomas Chalopin, Isabelle Barillot, Jean-Paul Biny, Flavie Arbion, Marie Besson, Maria Santiago-Ribeiro, Eric Piver, Olivier Herault, Emmanuel Gyan, Lotfi Benboubker
BACKGROUND: Solitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia. To the best of our knowledge, very few cases have been reported without systemic disease. We reported a rare case of hepatic solitary plasmacytoma that successfully responded to fractionated stereotactic radiotherapy. CASE PRESENTATION: A 64-year-old white French man had monoclonal gammopathy of the immune globulin G lambda type; he developed a cholestasis and cytolysis with the discovery of a subscapular nodule...
July 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28711413/-hypofractionated-stereotactic-radiotherapy-for-brain-metastasis-benefit-of-additional-whole-brain-radiotherapy
#2
P Royer, J Salleron, G Vogin, L Taillandier, C Clément-Duchêne, O Klein, J-C Faivre, D Peiffert, V Bernier
PURPOSE: To study overall survival, risk of neurological death, local recurrence and development of new brain metastasis in patients treated for brain oligometastases with hypofractionated stereotactic radiotherapy with CyberKnife(®), according to the association or not with an additional whole brain irradiation. PATIENTS AND METHODS: Institutional retrospective study of 102 patients treated for one to three brain metastasis: 76 with exclusive hypofractionated stereotactic radiotherapy and 26 with hypofractionated stereotactic radiotherapy and whole brain irradiation...
July 12, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28711188/plan-delivery-quality-assurance-for-cyberknife-statistical-process-control-analysis-of-350-film-based-patient-specific-qas
#3
J Bellec, N Delaby, F Jouyaux, M Perdrieux, J Bouvier, S Sorel, O Henry, C Lafond
PURPOSE: Robotic radiosurgery requires plan delivery quality assurance (DQA) but there has never been a published comprehensive analysis of a patient-specific DQA process in a clinic. We proposed to evaluate 350 consecutive film-based patient-specific DQAs using statistical process control. We evaluated the performance of the process to propose achievable tolerance criteria for DQA validation and we sought to identify suboptimal DQA using control charts. METHODS AND MATERIAL: DQAs were performed on a CyberKnife-M6 using Gafchromic-EBT3 films...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28699351/ultrahypofractionated-cyberknifetm-based-stereotactic-radiotherapy-versus-conventional-radiotherapy-in-patients-with-prostate-cancer-acute-toxicity-evaluation-in-two-phase-ii-prospective-studies
#4
G Głowacki, W Majewski, P Wojcieszek, K Grabinska, G Wozniak, L Miszczyk
Our purpose was to compare the acute toxicity of ultrahypofractionated CyberKnifeTM based stereotactic radiotherapy (SBRT Arm) and conventional radiotherapy (EBRT Arm) in prostate cancer patients. Two-hundred-sixteen men with prostate cancer were enrolled in our prospective studies. One-hundred and nine were irradiated using CyberKnife to total dose of 36,25 Gy in 5 fractions. One-hundred and seven were irradiated conventionally to total dose of 76 Gy in 38 fractions. Mean age of patients was 69. Acute genitourinary (GU) and gastrointestinal (GI) adverse-events were collected...
2017: Neoplasma
https://www.readbyqxmd.com/read/28681423/multi-stage-stereotactic-radiosurgery-for-large-cerebral-arteriovenous-malformations-using-the-gamma-knife-platform
#5
Chuxiong Ding, Brian Hrycushko, Louis Whitworth, Xiang Li, Lucien Nedzi, Bradley Weprin, Ramzi Abdulrahman, Babu Welch, Steve B Jiang, Zabi Wardak, Robert D Timmerman
PURPOSE: Radiosurgery is an established technique to treat Cerebral Arteriovenous Malformations (AVMs). Obliteration of larger AVMs (>10-15 cm(3) or diameter > 3 cm) in a single session is challenging with current radiosurgery platforms due to toxicity. We present a novel technique of multi-stage stereotactic radiosurgery (SRS) for large intracranial arteriovenous malformations (AVM) using the Gamma Knife system. MATERIALS/METHODS: Eighteen patients with large (>10-15 cm(3) or diameter ⩾3 cm) AVMs, which were previously treated using a staged SRS technique on the Cyberknife platform, were retrospectively selected for this study...
July 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28681125/a-cross-sectional-review-of-patient-information-available-in-the-world-wide-web-on-cyberknife-fallacies-and-pitfalls
#6
Durgapoorna Menon, Prameela G Chelakkot, Devika Sunil, Ashwini Lakshmaiah
PURPOSE: The purpose of this study is to assess the quality of videos available in YouTube on CyberKnife. METHODS: The term "CyberKnife" was input into the search window of www.youtube.com on a specific date and the first 50 videos were assessed for technical and content issues. The data was tabulated and analysed. RESULTS: The search yielded 32,300 videos in 0.33 s. Among the first 50 analysed, most were professional videos, mostly on CyberKnife in general and for brain tumours...
July 5, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28662849/use-of-an-in-house-monte-carlo-platform-to-assess-the-clinical-impact-of-algorithm-related-dose-differences-on-dvh-constraints
#7
A Wagner, F Crop, X Mirabel, C Tailly, N Reynaert
PURPOSE: The aim of the present work is to evaluate a semi-automatic prescription and validation system of treatment plans for complex delivery techniques, integrated in a Monte Carlo platform, and to investigate the clinical impact of dose differences due to the calculation algorithms, by assessing the changes in DVH constraints. METHODS: A new prescription module was implemented into the Moderato system, an in-house Monte Carlo platform, with corresponding dose constraints generated depending on the anatomical region and fractionation scheme considered...
June 26, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28657157/cyberknife-with-integrated-ct-on-rails-system-description-and-first-clinical-application-for-pancreas-sbrt
#8
Chrysi Papalazarou, Gijsbert J Klop, Maaike T W Milder, Johannes P A Marijnissen, Vikas Gupta, Ben J M Heijmen, Joost J M E Nuyttens, Mischa S Hoogeman
PURPOSE: This paper reports on the integration of a sliding-gantry CT-on-rails with a robotic linear accelerator. METHODS: The system consists of a SOMATOM Definition AS CT scanner (Siemens Healthcare, Forchheim, Germany) and a CyberKnife M6 FIM (Accuray, Inc., Sunnyvale, CA, USA). Additional movement programs were implemented in the robotic treatment table (RoboCouch, Accuray Inc.) to move between CT and treatment position. Acceptance testing was performed on the CT scanner according to AAPM83 guidelines, as well as safety tests for collision avoidance and electromagnetic (EM) compatibility...
June 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28649970/cyberarc-a-non-coplanar-arc-optimization-algorithm-for-cyberknife
#9
Vasant Kearney, Joey P Cheung, Christopher McGuinness, Timothy D Solberg
The goal of this study is to demonstrate the feasibility of a novel non-coplanar-arc optimization algorithm (CyberArc). This method aims to reduce the delivery time of conventional CyberKnife treatments by allowing for continuous beam delivery. CyberArc uses a 4 step optimization strategy, in which nodes, beams, and collimator sizes are determined, source trajectories are calculated, intermediate radiation models are generated, and final monitor units are calculated, for the continuous radiation source model...
June 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28643730/an-overview-on-small-field-dosimetry-in-photon-beam-radiotherapy-developments-and-challenges
#10
REVIEW
Hamed Bagheri, Azadeh Soleimani, Nahideh Gharehaghaji, Asghar Mesbahi, Farhad Manouchehri, Babak Shekarchi, Banafsheh Dormanesh, Habib Alah Dadgar
Small fields are more repeatedly used for radiation therapy as small segments in intensity-modulated radiotherapy or as in the form of independent fields in stereotactic radiosurgery and other novel equipment such as cyberknife and tomotherapy. Nevertheless, the application of small fields for radiotherapy of lung makes the dose calculation and planning inaccurate due to the existence of electronic disequilibrium and intrinsic deficiencies within most of the analytical dose calculation algorithms. The current review attempts to gather the information in this regard and focuses on the current progresses and retaining issues associated with this type of photon beams...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28629928/safety-and-efficacy-of-endovascular-fiducial-marker-insertion-for-cyberknife-stereotactic-radiation-therapy-planning-in-early-stage-lung-cancer
#11
Mikael Mongeon, Florence Thibault, Carl Chartrand-Lefebvre, Andrei-Bogdan Gorgos, Gilles Soulez, Edith Filion, Eric Therasse
PURPOSE: To evaluate the safety and efficacy of endovascular fiducial markers (EVFMs) for CyberKnife stereotactic radiation therapy (RT) of malignant lung neoplasms in patients with contraindications to percutaneous fiducial marker (PTFM) placement. MATERIALS AND METHODS: Between January 2011 and December 2013, 15 patients (7 men and 8 women) aged 59-87 years (mean, 73 y) underwent EVFM placement and 109 patients (54 men and 55 women) aged 55-92 years (mean, 73 y) underwent 114 PTFM placements...
June 16, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28586956/stereotactic-radiosurgery-and-fractionated-stereotactic-radiation-therapy-for-the-treatment-of-uveal-melanoma
#12
Gozde Yazici, Hayyam Kiratli, Gokhan Ozyigit, Sezin Yuce Sari, Mustafa Cengiz, Bercin Tarlan, Burce Ozgen Mocan, Faruk Zorlu
PURPOSE: To evaluate treatment results of stereotactic radiosurgery or fractionated stereotactic radiation therapy (SRS/FSRT) for uveal melanoma. METHODS AND MATERIALS: We retrospectively evaluated 181 patients with 182 uveal melanomas receiving SRS/FSRT between 2007 and 2013. Treatment was administered with CyberKnife. RESULTS: According to Collaborative Ocular Melanoma Study criteria, tumor size was small in 1%, medium in 49.5%, and large in 49...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28545199/cyberknife-radioablation-of-prostate-cancer-%C3%A2-preliminary-results-for-400-patients
#13
Leszek Miszczyk, Agnieszka Namysł Kaletka, Aleksandra Napieralska, Grzegorz Woźniak, Małgorzata Stąpór Fudzińska, Grzegorz Głowacki, Andrzej Tukiendorf
Objectives: To evaluate the tolerance and effectiveness of stereotactic ablative radiotherapy (SABR) applied in the treatment of low and intermediate risk (LR & IR) prostate cancer patients (PCP) and provide an evaluation of the level of risk group impact on treatment results. In addition, androgen deprivation therapy (ADT) usage and prostatic specific antigen (PSA) decline after SABR were assessed. Material and Methods: A total of 400 PCP (213 LR and 187 IR, including T2c) were irradiated with a CyberKnife using fd 7...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544809/robotic-radiosurgery-of-head-and-neck-paragangliomas-a-single-institution-experience
#14
İlker Tosun, Banu Atalar, Bilgehan Şahin, Görkem Güngör, Gökhan Aydin, Bülent Yapici, Enis Özyar
AIM: CyberKnife(®) is a robotic stereotactic radiotherapy system. The aim of this study is to evaluate the effectiveness and the safety of CyberKnife(®) on treating head and neck paragangliomas and to report our results. METHODS: Between March 2009 and June 2014, 12 patients with head and neck paragangliomas have been referred to our clinic: in three cases had jugular paragangliomas, five cases had carotid body paragangliomas and three cases had tympanic paragangliomas...
May 24, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28535920/cyberknife%C3%A2-m6%C3%A2-peripheral-dose-evaluation-for-brain-treatments
#15
N Delaby, J Bellec, J Bouvier, F Jouyaux, M Perdrieux, J Castelli, I Lecouillard, J P Manens, C Lafond
PURPOSE: This study evaluates the peripheral dose (PD) delivered to healthy tissues for brain stereotactic radiotherapy treatments (SRT) performed with a CyberKnife M6™ Robotic Radiosurgery System and proposes a model to estimate PD before treatment. METHOD: PD was measured with thermoluminescent dosimeters. Measurements were performed to evaluate the influence of distance, collimator type (fixed or Iris™) and aperture size on PD for typical brain treatment plans simulated on an anthropomorphic phantom...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28514930/hypofractionated-stereotactic-body-radiotherapy-for-localized-prostate-cancer-first-nordic-clinical-experience
#16
Kristiina Koskela, Jan-Erik Palmgren, Janne Heikkilä, Heli Virsunen, Liisa Sailas, Päivi Auvinen, Jan Seppälä, Vesa Kataja
BACKGROUND: The use of hypofractionated stereotactic body radiotherapy (SBRT) as primary treatment modality in clinically localized prostate cancer (PCa) is emerging, because the low α/β-ratio favors the use of high dose per fraction in PCa. There is a need for more data about SBRT, especially in high-risk PCa patients. The purpose of this retrospective study was to evaluate the safety and the short-term efficacy of robotic SBRT in a clinical patient cohort with localized PCa including also high-risk patients (D'Amico risk stratification)...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28512412/sudden-onset-of-brain-metastasis-despite-the-use-of-vemurafenib-for-another-metastatic-lesion-in-malignant-melanoma-patients
#17
Keisuke Imafuku, Koji Yoshino, Kei Yamaguchi, Satoshi Tsuboi, Kuniaki Ohara, Hiroo Hata
Vemurafenib is an inhibitor of the BRAF mutation and has been approved by the Food and Drug Administration as a treatment option for patients with unresectable melanoma without brain metastasis. In the literature, vemurafenib has been reported to be also effective against brain metastasis. We encountered 3 cases with brain metastasis on vemurafenib therapy. In these cases, vemurafenib was clinically effective against metastatic lesions other than those in the brain. The brain lesions developed after the metastatic lesion had occurred...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28486221/evaluation-of-clinical-application-and-dosimetric-comparison-of-treatment-plans-of-gamma-knife-and-cyberknife-in-treating-arteriovenous-malformations
#18
Chun-Yuan Kuo, Yi-Chieh Tsai, An-Cheng Shiau, Hao-Wen Cheng, Hsiao-Wei Yu, Yu-Kai Su, Jo-Ting Tsai
PURPOSE: To analyze and compare the characteristics of dose distributions for Leksell Gamma Knife Perfexion (LGK-PFX) and CyberKnife (CK) in treating arteriovenous malformations (AVMs). SUBJECTS AND METHODS: Twenty-four patients with AVMs who received CK radiosurgery at a prescribed dose (PD) of 16-25 Gy in a single fraction were selected. A LGK-PFX treatment plan with the same PD was designed for each patient. Dosimetric values for both systems were compared with respect to the conformity index (CI); selectivity index (SI); gradient index (GI) of 75, 50, and 25% of the PD; heterogeneity index; volume of the brain tissue covered by doses of 10 and 12 Gy; maximum dose delivered to the brainstem; and beam-on time...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28462852/stereotactic-robotic-body-radiotherapy-for-patients-with-unresectable-hepatic-oligorecurrence
#19
Patrick Berkovic, Akos Gulyban, Paul Viet Nguyen, David Dechambre, Philippe Martinive, Nicolas Jansen, Ferenc Lakosi, Levente Janvary, Philippe A Coucke
BACKGROUND: The purpose of this study was to analyze local control (LC), liver progression-free survival (PFS), and distant PFS (DFS), overall survival (OS), and toxicity in a cohort of patients treated with stereotactic body radiotherapy (SBRT) with fiducial tracking for oligorecurrent liver lesions; and to evaluate the potential influence of lesion size, systemic treatment, physical and biologically effective dose (BED), treatment calculation algorithms and other parameters on the obtained results...
March 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28454993/frameless-stereotactic-radiosurgery-for-treatment-of-multiple-sclerosis-related-trigeminal-neuralgia
#20
Alfredo Conti, Antonio Pontoriero, Giuseppe Iatì, Felice Esposito, Enrico Nastro Siniscalchi, Salvatore Crimi, Sergio Vinci, Anna Brogna, Francesco De Ponte, Antonino Germanò, Stefano Pergolizzi, Francesco Tomasello
BACKGROUND: Trigeminal neuralgia (TN) affects 7% of patients with multiple sclerosis (MS). In such patients, TN is difficult to manage either pharmacologically and surgically. Radiosurgical rhizotomy is an effective treatment option. The nonisocentric geometry of radiation beams of CyberKnife introduces new concepts in the treatment of TN. Its efficacy for MS-related TN has not yet been demonstrated. METHODS: Twenty-seven patients with refractory TN and MS were treated...
July 2017: World Neurosurgery
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