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CyberKnife

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https://www.readbyqxmd.com/read/29760591/cyberknife-stereotactic-radiosurgery-in-brain-metastases-a-report-from-latin-america-with-literature-review
#1
Cuauhtémoc de la Peña, Jorge H Guajardo, María F Gonzalez, César González, Benjamín Cruz
Background and aim: Stereotactic radiosurgery is increasingly being employed for the treatment of brain metastases, both as an adjuvant to surgical resection, and also as a primary treatment modality. The aim of this study is to evaluate overall survival and local control in patients with brain metastases treated with CyberKnife Stereotactic Radiosurgery (CKRS), due to the lack of evidence reported in Latin America. Materials and methods: We performed a retrospective chart review from October 2011 to January 2017 of 49 patients with 152 brain metastases...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29752992/radiosurgery-reduces-plasma-levels-of-angiogenic-factors-in-brain-arteriovenous-malformation-patients
#2
Ming Xu, Xiaoxia Liu, Guanghai Mei, Junjie Zhang, Weixing Wang, Hongzhi Xu
PURPOSE: Aberrant expression of angiogenic factors has been anecdotally documented in brain arteriovenous malformation (AVM) nidus vessels; however, no data is available on the effect of radiosurgery on the levels of angiogenic factors in AVM patients. We sought to determine the plasma contents of VEGF, TGF-β, Ang-2 and bFGF in 28 brain AVM patients at baseline and post radiosurgery and further analyzed the relationship between plasma contents of these angiogenic factors with clinicopathologic variables of these patients...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29714660/second-pelvic-recurrence-of-rectal-cancer-successfully-treated-with-a-re-reirradiation-3rd-radiation-course
#3
Veronica Dell'Acqua, Annamaria Ferrari, Delia Ciardo, Gaia Piperno, Sabrina Vigorito, Mariacristina Leonardi, Samantha Dicuonzo, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
In case of pelvic recurrence of colorectal cancer, reirradiation of previously irradiated patients may increase the rate of salvage radical resection. Due to the high cumulative dose, one of the main concerns is radiation-induced lumbosacral plexopathy. This report describes multiple irradiations of a lesion adjacent to the lumbosacral plexus, using a highly selective technique, which allows optimal sparing of such a critical structure. Case description A 53-year-old woman treated in 2008 for a locally advanced rectal adenocarcinoma with preoperative pelvic irradiation and concomitant chemotherapy followed by surgery had disease recurrence in 2011 and underwent a second course of pelvic radiotherapy...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29701555/stereotactic-radiosurgery-for-trigeminal-neuralgia-a-systematic-review
#4
Constantin Tuleasca, Jean Régis, Arjun Sahgal, Antonio De Salles, Motohiro Hayashi, Lijun Ma, Roberto Martínez-Álvarez, Ian Paddick, Samuel Ryu, Ben J Slotman, Marc Levivier
OBJECTIVES The aims of this systematic review are to provide an objective summary of the published literature specific to the treatment of classical trigeminal neuralgia with stereotactic radiosurgery (RS) and to develop consensus guideline recommendations for the use of RS, as endorsed by the International Society of Stereotactic Radiosurgery (ISRS). METHODS The authors performed a systematic review of the English-language literature from 1951 up to December 2015 using the Embase, PubMed, and MEDLINE databases...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678159/stereotactic-body-radiation-therapy-as-an-effective-and-safe-treatment-for-small-hepatocellular-carcinoma
#5
Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu, Xuezhang Duan
BACKGROUND: To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with small hepatocellular carcinoma(sHCC) who were ineligible for surgery or ablation therapies. METHODS: From March 2011 to December 2012, 28 cases with sHCC which were ineligible or refused surgical resection, transplantation or local ablation were treated with CyberKnife SBRT. Median size of tumors was 2.1 cm (range:1.1-3.0 cm), a dose of 10-15Gy per faction was given over 3-6 consecutive days, resulting in a total dose of 35-60Gy...
April 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29656632/long-term-survival-in-patients-treated-with-a-robotic-radiosurgical-device-for-liver-metastases
#6
Sebastian Stintzing, Jobst von Einem, Christoph Fueweger, Alfred Haidenberger, Michael Fedorov, Alexander Muavcevic
Purpose: The treatment of liver metastases with local procedures is a fast progressing field. For the most, long-term survival data is missing raising questions with regard to the efficacy of such modalities when compared to surgical resection. Radiosurgery using the CyberKnife device enables the treatment of liver lesions with a single-session approach. Here we present long-term survival data to explore the curative potential of this strategy. Materials and Methods: Patients with oligo-metastatic disease limited to the liver have been treated with single-session or hypo-fractioned radiosurgery in curative intent and prospectively followed until death...
April 16, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29621319/dosimetric-impact-of-intra-fraction-prostate-motion-under-a-tumour-tracking-system-in-hypofractionated-robotic-radiosurgery
#7
Yuhei Koike, Iori Sumida, Hirokazu Mizuno, Hiroya Shiomi, Keita Kurosu, Seiichi Ota, Yasuo Yoshioka, Osamu Suzuki, Keisuke Tamari, Kazuhiko Ogawa
For CyberKnife-mediated prostate cancer treatment, a tumour-tracking approach is applied to correct the target location by acquiring X-ray images of implanted fiducial markers intermittently. This study investigated the dosimetric impact of intra-fraction prostate motion during CyberKnife treatment. We retrospectively analyzed 16 patients treated using the CyberKnife (35 Gy delivered in five fractions). Using log files of recorded prostate motion, the intra-fraction prostate motion was simulated. We defined the worst-case intra-fraction prostate motion as the difference between pre- and post-deviation on log files and shifted structure sets according to the corresponding offsets for each beam...
2018: PloS One
https://www.readbyqxmd.com/read/29609646/stereotactic-body-radiotherapy-boost-dose-of-18-gy-vs-21-gy-in-combination-with-androgen-deprivation-therapy-and-whole-pelvic-radiotherapy-for-intermediate-or-high-risk-prostate-cancer-a-study-protocol-for-a-randomized-controlled-pilot-trial
#8
Yeon Joo Kim, Hanjong Ahn, Choung-Soo Kim, Jae-Lyun Lee, Young Seok Kim
BACKGROUND: Combination therapy using external-beam radiotherapy (EBRT) with a brachytherapy boost has demonstrated superior biochemical control than dose-escalated EBRT alone. Whereas brachytherapy is disadvantageous because it is an invasive procedure, stereotactic body-radiotherapy (SBRT) using CyberKnife could emulate the dose distribution of brachytherapy and is a non-invasive and safe modality to control intra-fractional movement. We therefore adopted SBRT using CyberKnife as a boost therapy after whole-pelvic radiotherapy (WPRT)...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29607633/analysis-of-motion-dependent-clinical-outcome-of-tumor-tracking-stereotactic-body-radiotherapy-for-prostate-cancer
#9
Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Jin Ho Song, Yun Hee Lee, In Bong Ha, Sung Chul Kam, Jeong Seok Hwa, Jae Seog Hyun, Jungmo Do, Dong Hyeok Jeong, Hojin Jeong
BACKGROUND: To analyze clinical outcome of CyberKnife (CK) tumor-tracking stereotactic body radiotherapy (SBRT) for prostate cancer (Pca) according to the magnitude of intra-fractional prostate motion. METHODS: Medical records and daily treatment logs for 71 patients who received CK tumor-tracking SBRT were retrospectively analyzed. Statistical relationships between prostate motion and various outcome results, including local recurrence (LR), biochemical failure (BF), and treatment-related toxicity, were investigated in order to evaluate motion-dependent efficacy of tumor-tracking SBRT for Pca...
April 2, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29605528/cyberknife-stereotactic-radiosurgery-and-radiation-therapy-treatment-planning-system
#10
REVIEW
Chuxiong Ding, Cheng B Saw, Robert D Timmerman
CyberKnife is an image-guided stereotactical dose delivery system designed for both focal irradiation and radiation therapy (SRT). Focal irradiation refers the use of many small beams to deliver highly focus dose to a small target region in a few fractions. The system consists of a 6-MV linac mounted to a robotic arm, coupled with a digital x-ray imaging system. The radiation dose is delivered using many beams oriented at a number of defined or nodal positions around the patients. The CyberKnife can be used for both intracranial and extracranial treaments unlike the Gamma Knife which is limited to intracranial cases...
March 28, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29603564/film-based-dose-validation-of-monte-carlo-algorithm-for-cyberknife-system-with-a-cirs-thorax-phantom
#11
Yuxi Pan, Ruijie Yang, Jun Li, Xile Zhang, Lu Liu, Junjie Wang
Monte Carlo (MC) simulation, as the most accurate dose calculation algorithm, is available in the MultiPlan treatment planning system for Cyberknife. The main purpose of this work was to perform experiments to thoroughly investigate the accuracy of the MC dose calculation algorithm. Besides the basic MC beam commissioning, two test scenarios were designed. First, single beam tests were performed with a solid water phantom to verify the MC source model in simple geometry. Then, a lung treatment plan on a CIRS thorax phantom was created to mimic the clinical patient treatment...
March 30, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29587486/cyberknife-radiotherapy-for-orbital-metastases-a-single-center-experience-on-24-lesions
#12
Giulia Riva, Matteo Augugliaro, Gaia Piperno, Annamaria Ferrari, Elena Rondi, Sabrina Vigorito, Delia Ciardo, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
OBJECTIVES: To evaluate the feasibility, in terms of acute toxicity and symptom control, of CyberKnife (Accuray, Sunnyvale, CA)-based stereotactic radiotherapy (CyberKnife-SRT) for metastatic orbital lesions. METHODS: This retrospective study included patients with symptomatic metastases wholly located within the orbit. Palliative radiation treatment was performed using CyberKnife image-guided technology. Gross tumor volume was defined on a pre-radiotherapy magnetic resonance imaging...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29566762/partial-breast-irradiation-with-cyberknife-after-breast-conserving-surgery-a-pilot-study-in-early-breast-cancer
#13
Laura Lozza, Laura Fariselli, Marco Sandri, Mario Rampa, Valentina Pinzi, Maria Carmen De Santis, Marzia Franceschini, Giovanna Trecate, Ilaria Maugeri, Luisa Fumagalli, Francesca Bonfantini, Giulia Bianchi, Emanuele Pignoli, Elena De Martin, Roberto Agresti
BACKGROUND: Local recurrences after breast conserving treatment are mainly close to the original tumor site, and as such shorter fractionation strategies focused on and nearest mammary gland, i.e. accelerated partial breast irradiation (APBI), have been developed. Stereotactic APBI has been attempted, although there is little experience using CyberKnife (CK) for early breast cancer. METHODS: This pilot study was designed to assess the feasibility of CK-APBI on 20 evaluable patients of 29 eligible, followed for 2 years...
March 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29554976/ovarian-metastases-from-gallbladder-mimics-primary-ovarian-neoplasm-in-young-patient-a-case-report
#14
Ting-Ying Lee, Chia-Wen Wang, Teng-Wei Chen, De-Chuan Chan, Guo-Shiou Liao, Hsiu-Lung Fan
BACKGROUND: Gallbladder cancer is unusually seen but can result in highly mortality rate. It makes challenge to diagnose for clinicians due to present asymptomatic or non-specific clinical presentation including abdominal pain, anorexia. It usually also accompanies with cholelithiasis (incidence is 1-2%) and incidentally detected by radiologic examination such as ultrasound, computed tomography or intra-operative intervention accidentally. Gallbladder cancer results in highly fatal malignancy because it is difficult to early detect...
March 20, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29552780/patient-specific-quality-assurance-for-intracranial-cases-in-robotic-radiosurgery-system
#15
Canan Koksal, Ugur Akbas, Nazmiye Donmez Kesen, Murat Okutan, Hatice Bilge, Gonul Kemikler
PURPOSE: The purpose of this study was to perform pretreatment patient-specific quality assurance (QA) for intracranial irradiation using CyberKnife with an ion chamber. METHODS: Twenty-five intracranial plans created using the ray-tracing algorithm were used for this study. Computed tomography (CT) images of the water-equivalent RW3 slab phantom with PinPoint ionization chamber were acquired with 1-mm slice thickness and transferred to the MultiPlan treatment planning system (TPS)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29545428/metastatic-primary-pulmonary-melanoma-successfully-treated-with-checkpoint-inhibitors
#16
Georges Al-Helou, Nardos Temesgen, Jonathan Gwizdala, Jalil Ahari
Our patient is a 69-year-old man who presented to the emergency department with left-sided hemiparesis that started 4 hours prior to presentation. Brain CT showed right basal ganglia and internal capsule haemorrhagic strokes. MRI revealed multiple brain lesions suspicious for metastases. Further workup revealed a 5 cm lung mass and a 1 cm pancreatic nodule. Biopsy of both pulmonary and pancreatic lesions was consistent with melanoma and was similar histologically. The patient underwent cyberknife stereotactic radiosurgery to the brain metastases followed by immunotherapy with pembrolizumab, and then by nivolumab and ipilimumab...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29545019/photons-protons-or-carbon-ions-for-stage-i-non-small-cell-lung-cancer-results-of-the-multicentric-rococo-in-silico-study
#17
Krista C J Wink, Erik Roelofs, Charles B Simone, David Dechambre, Alina Santiago, Judith van der Stoep, Wim Dries, Julia Smits, Stephen Avery, Filippo Ammazzalorso, Nicolas Jansen, Urszula Jelen, Timothy Solberg, Dirk de Ruysscher, Esther G C Troost
PURPOSE: To compare dose to organs at risk (OARs) and dose-escalation possibility for 24 stage I non-small cell lung cancer (NSCLC) patients in a ROCOCO (Radiation Oncology Collaborative Comparison) trial. METHODS: For each patient, 3 photon plans [Intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and CyberKnife], a double scattered proton (DSP) and an intensity-modulated carbon-ion (IMIT) therapy plan were created. Dose prescription was 60 Gy (equivalent) in 8 fractions...
March 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29544504/in-silico-assessment-of-the-dosimetric-quality-of-a-novel-automated-radiation-treatment-planning-strategy-for-linac-based-radiosurgery-of-multiple-brain-metastases-and-a-comparison-with-robotic-methods
#18
Krzysztof Slosarek, Barbara Bekman, Jacek Wendykier, Aleksandra Grządziel, Antonella Fogliata, Luca Cozzi
BACKGROUND: To appraise the dosimetric features and the quality of the treatment plan for radiosurgery of multiple brain metastases optimized with a novel automated engine and to compare with plans optimized for robotic-based delivery. METHODS: A set of 15 patients with multiple brain metastases was selected for this in silico study. The technique under investigation is the recently introduced HyperArc. For all patients, three treatment plans were computed and compared: i: a HyperArc; ii: a standard VMAT; iii) a CyberKnife...
March 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29542260/comparative-analysis-for-renal-stereotactic-body-radiotherapy-using-cyberknife-vmat-and-proton-therapy-based-treatment-planning
#19
Atallah Baydoun, Neha Vapiwala, Lee E Ponsky, Musaddiq Awan, Ali Kassaee, David Sutton, Tarun K Podder, Yuxia Zhang, Donald Dobbins, Raymond F Muzic, Bryan Traughber, Mitchell Machtay, Rodney Ellis
PURPOSE: We conducted this dosimetric analysis to evaluate the feasibility of a multi-center stereotactic body radiation therapy (SBRT) trial for renal cell carcinoma (RCC) using different SBRT platforms. MATERIALS/METHODS: The computed tomography (CT) simulation images of 10 patients with unilateral RCC previously treated on a Phase 1 trial at Institution 1 were anonymized and shared with Institution 2 after IRB approval. Treatment planning was generated through five different platforms aiming a total dose of 48 Gy in three fractions...
March 14, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29533338/radiosurgery-of-glomus-tumors-of-temporal-bone-a-meta-analysis
#20
Ronald Sahyouni, Hossein Mahboubi, Omid Moshtaghi, Khodayar Goshtasbi, Sammy Sahyouni, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: 1) Perform a meta-analysis of the available data on the outcomes of stereotactic radiosurgery (SRS) for the treatment of temporal bone glomus tumors (GT), and 2) evaluate the collective outcomes of SRS treatment with respect to tumor control. DATA SOURCES: A thorough literature search of the published English-language literature from 2011 to 2016 was performed in PubMed, Ovid, and Cochrane databases using the keywords ("Gamma Knife" or "CyberKnife" or "linear accelerator" or "radiosurgery") and ("glomus jugulare" or "jugular paraganglioma" or "glomus tympanicum")...
April 2018: Otology & Neurotology
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