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CyberKnife

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https://www.readbyqxmd.com/read/29350197/a-three-dimensional-correction-method-for-predicting-the-readings-of-a-pinpoint-chamber-on-the-cyberknife-sup-%C3%A2-sup-m6%C3%A2-machine
#1
Yongqian Zhang, Edward Brandner, Cihat Ozhasoglu, Ron Lalonde, Dwight E Heron, M Saiful Huq
The use of small fields in radiation therapy techniques has increased substantially in particular in stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). However, as field size reduces further still, the response of the detector changes more rapidly with field size, and the effects of measurement uncertainties become increasingly significant. This work presents a novel 3D dose volume-to-point correction method to predict the readings of a 0.015cc PinPoint chamber (PTW 31014) for both small static-fields and composite-field dosimetry formed by fixed cones on the CyberKnife® M6™ machine...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29329997/clinical-log-data-analysis-for-assessing-the-accuracy-of-the-cyberknife-fiducial-free-lung-tumor-tracking-system
#2
Masao Nakayama, Hideki Nishimura, Hiroshi Mayahara, Masaki Nakamura, Kazuyuki Uehara, Shinji Tsudou, Aya Harada, Hiroaki Akasaka, Ryohei Sasaki
PURPOSE: The CyberKnife Xsight Lung Tracking (XLT) and 1-View tracking systems can synchronize beam targeting to a visible lung tumor with respiratory motion during irradiation without requiring internal fiducial markers. The systems use a correlation model that relates external marker positions to tumor positions as well as a prediction model that predicts the target's future position. In this study, the correlation and prediction model uncertainties related to the CyberKnife fiducial-free tumor tracking system were evaluated using clinical log data...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29300187/a-treatment-planning-comparison-between-a-novel-rotating-gamma-system-and-robotic-linear-accelerator-based-intracranial-stereotactic-radiosurgery-radiotherapy
#3
Muhammad Mohsin Fareed, Ahmed A Eldib, Stephanie E Weiss, Shelly B Hayes, Jinsheng Li, Chang-Ming Charlie Ma
Purpose: To compare the dosimetric parameters of a novel Rotating Gamma Ray System (RGS) with well-established CyberKnife system (CK) for treating malignant brain lesions. Materials and Methods: RGS has a treatment head of 16 cobalt-60 sources focused to the isocenter, which can rotate 360° on the ring gantry and swing 35° in the superior direction. We compared several dosimetric parameters in 10 patients undergoing brain stereotactic radiosurgery including plan normalization, the number of beams and nodes for CK and shots for RGS, collimators used, estimated treatment time, D 2 cm and conformity index (CI) among two modalities...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29282442/impact-of-cyberknife-radiosurgery-on-overall-survival-and-various-parameters-of-patients-with-1-3-versus-%C3%A2-4-brain-metastases
#4
Judith Murovic, Victoria Ding, Summer S Han, John R Adler, Steven D Chang
Introduction This study's objective is to compare the overall survivals (OSs) and various parameters of patients with 1-3 versus ≥ 4 brain metastases post-CyberKnife radiosurgery (CKRS) (Accuray, Sunnyvale, California) alone. Methods Charts of 150 patients, from 2009-2014, treated with only CKRS for brain metastases were reviewed retrospectively for overall survival (OS) and patient, tumor, and imaging characteristics. Parameters included demographics, Eastern Cooperative Oncology Group (ECOG) performance scores, number and control of extracranial disease (ECD) sites, cause of death (COD), histology, tumor volume (TV), and post-CKRS whole brain radiotherapy (WBRT)...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29279492/cyberknife-stereotactic-radiosurgery-for-cholangiocarcinoma
#5
Yuko Harada, Shinichiro Miyazaki
Cholangiocarcinoma is a devastating cancer with a poor prognosis. Patients are often diagnosed at the advanced stage, and curative surgery is impossible. Radiation therapy is used for cases of advanced cancer. A 50-year-old woman with stage IVb intrahepatic cholangiocarcinoma was diagnosed with unresectable cancer, and had chemotherapy; however, the disease progressed. CyberKnife radiosurgery was performed, which was able to control the symptoms of liver failure and prolong her life. Her symptoms, which included jaundice, ascites, and edema disappeared and her tumor markers became normal...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29244902/feasibility-of-predicting-tumor-motion-using-online-data-acquired-during-treatment-and-a-generalized-neural-network-optimized-with-offline-patient-tumor-trajectories
#6
Troy Teo, Syed Bilal Ahmed, Nadia Alayoubi, Neil Bruce, Ethan Lyn, Stephen Pistorius
PURPOSE: The accurate prediction of intra-fraction lung tumor motion is required to compensate for system latency in image-guided adaptive radiotherapy systems. The goal of this study was to identify an optimal prediction model that has a short learning period so that prediction and adaptation can commence soon after treatment begins, and requires minimal re-optimization for individual patients. Specifically, the feasibility of predicting tumor position using a combination of a generalized (i...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29217830/patient-reported-quality-of-life-progression-in-men-with-prostate-cancer-following-primary-cryotherapy-cyberknife-or-active-holistic-surveillance
#7
Glenn T Werneburg, Michael Kongnyuy, Daniel M Halpern, Jose M Salcedo, Kaitlin E Kosinski, Jonathan A Haas, Jeffrey T Schiff, Anthony T Corcoran, Aaron E Katz
BACKGROUND: Technological advancements have led to the success of minimally invasive treatment modalities for prostate cancer such as CyberKnife and Cryotherapy. Here, we investigate patient-reported urinary function, bowel habits, and sexual function in patients following CyberKnife (CK) or Cryotherapy treatment, and compare them with active holistic surveillance (AHS) patients. METHODS: An IRB-approved institutional database was retrospectively reviewed for patients who underwent CK, Cryotherapy, or AHS...
December 7, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29212171/clinical-outcomes-and-prognostic-factors-of-stereotactic-body-radiation-therapy-for-intrahepatic-cholangiocarcinoma
#8
Ze-Tian Shen, Han Zhou, Ao-Mei Li, Bing Li, Jun-Shu Shen, Xi-Xu Zhu
Stereotactic body radiation therapy (SBRT) has been an emerging non-invasive treatment modality for patients with intrahepatic cholangiocarcinoma (ICC) when surgical treatment cannot be applied. The CyberKnife® is a SBRT system that allows for real-time tracking of the tumor. The purpose of this study was to evaluate the clinical outcomes and prognostic factors for ICC patients receiving this treatment. Twenty-eight patients with ICC were enrolled in the present study. The median prescription dose was 45 Gy (range, 36-54 Gy), fractionated 3 to 5 times with a 70% to 92% isodose line...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208480/robotic-stereotactic-retreatment-for-biochemical-control-in-previously-irradiated-patients-affected-by-recurrent-prostate-cancer
#9
M Loi, V Di Cataldo, G Simontacchi, B Detti, P Bonomo, L Masi, I Desideri, D Greto, G Francolini, V Carfora, D Pezzulla, M Perna, G A Carta, L Livi
AIMS: Robotic stereotactic body radiotherapy (rSBRT) to local recurrences emerged as a valuable option for exclusive local failure after prior external beam radiation therapy (EBRT) for localised prostate cancer. The aim of this study was to assess the efficacy and safety of rSBRT in patients experiencing locally recurrent prostate cancer after prior definitive or postoperative radiotherapy using the Cyberknife. MATERIALS AND METHODS: Data from 50 patients were retrospectively reviewed...
December 2, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29206077/radiosurgery-and-stereotactic-radiotherapy-with-cyberknife-system-for-meningioma-treatment
#10
Rossella Di Franco, Valentina Borzillo, Vincenzo Ravo, Sara Falivene, Francesco Jacopo Romano, Matteo Muto, Fabrizio Cammarota, Giuseppe Totaro, Gianluca Ametrano, Sabrina Rossetti, Carla Cavaliere, Carmine D' Aniello, Gelsomina Iovane, Maria Assunta Porricelli, Massimiliano Berretta, Gerardo Botti, Luigi Starace, Enrico La Salvia, Gaetano Facchini, Paolo Muto
Objective The aim of this work was to evaluate the impact of stereotactic radiosurgery/fractionated stereotactic radiotherapy with the Cyberknife system on local disease control, clinical outcome and toxicity in patients with meningioma, according to the site and histological grade of lesion. From January 2013 to April 2017, 52 patients with intracranial meningiomas were treated with the Cyberknife system. Twenty-four patients had undergone previous surgery: 38% gross total resection, 10% subtotal resection; 27 patients underwent no surgery; 22 patients had a recurrence of meningioma...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29187892/defining-radiation-induced-hepatic-toxicity-in-hepatocellular-carcinoma-patients-treated-with-stereotactic-body-radiotherapy
#11
Jin Ho Song, Bae-Kwon Jeong, Hoon-Sik Choi, Hojin Jeong, Yun Hee Lee, Hong Jun Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Hong Seok Jang, Byung Ock Choi, Ki Mun Kang
The definition and criteria of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients vary among studies. Therefore, the reported rates of RIHT differ among studies, and this causes confusion. In this study, we evaluated RIHT using several laboratory and clinical parameters, and analyzed which criterion is more correlated with RT and survival. Forty-five HCC patients treated with stereotactic body radiotherapy were included for the analysis. All patients had unresectable HCC and Child-Pugh (CP) class A or B baseline liver function...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29152425/stereotactic-body-radiotherapy-for-low-risk-prostate-cancer-a-ten-year-analysis
#12
Alan Katz
Objective This study represents the first 10 year analysis of the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of early low-risk prostate cancer. Materials and methods Two hundred and thirty males were treated with Cyberknife SBRT to a dose of 35 Gray (Gy) or 36.25 Gy in five consecutive days. All patients had a Gleason score of six and a PSA < 10ng/ml. Median follow-up is nine years. The median age was 69.5 years and median prostate specific antigen (PSA) was 5.6ng/ml...
September 9, 2017: Curēus
https://www.readbyqxmd.com/read/29148432/a-singular-value-decomposition-linear-programming-svdlp-optimization-technique-for-circular-cone-based-robotic-radiotherapy
#13
Bin Liang, Yongbao Li, Wei Ran, Bin Guo, Xuang Xu, Bo Liu, Jiafeng Li, Qiuwen Wu, Fugen Zhou
With robot-controlled linac positioning, the robotic radiotherapy system such as CyberKnife significantly increases the freedom in radiation beam placement, but also imposes more challenges on treatment plan optimization. The resampling mechanism in vendor supplied treatment planning system (MultiPlan) could not fully explore the increased beam direction search space. Besides, a sparse treatment plan (using fewer beams) is desired to improve the treatment efficiency. This study proposes a singular value decomposition linear programming (SVDLP) optimization technique for circular collimator based robotic radiotherapy...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29128197/reirradiation-of-gliomas-under-stereotactic-conditions-prognostic-factors-for-survival-without-relapse-or-side-effects-a-retrospective-study-at-tours-regional-university-hospital-france
#14
S Lévy, S Chapet, N Scher, K Debbi, A Ruffier, G Bernadou, Y Pointreau, G Calais
PURPOSE: To search for factors correlated with relapse-free survival following stereotactic reirradiation in patients with recurrent glioma following radiochemotherapy and evaluate tolerance to this treatment. PATIENTS AND METHODS: Initial radiotherapy was given according to the protocol of Stupp and al. Reirradiation was performed using the CyberKnife(®) system. Patients could have had surgical resection initially and at the time of recurrence. We analysed 13 patients treated between July 2010 and September 2014...
November 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29125234/evaluation-of-clinically-applied-treatment-beams-with-respect-to-bunker-shielding-parameters-for-a-cyberknife-m6
#15
Dominik Henzen, Daniel Schmidhalter, Claudia Christina Zanella, Werner Volken, Paul-Henry Mackeprang, Marco Malthaner, Michael Karl Fix, Peter Manser
Compared to a conventional linear accelerator, the Cyberknife (CK) is a unique system with respect to radiation protection shielding and the variety and number of non-coplanar beams are two key components regarding this aspect. In this work, a framework to assess the direction distribution and modulation factor (MF) of clinically applied treatment beams of a CyberKnife M6 is developed. Database filtering options allow studying the influence of different parameters such as collimator types, treatment sites or different bunker sizes...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29107720/sporadic-intradural-extramedullary-hemangioblastoma-of-the-cauda-equina-case-report-and-literature-review
#16
Douglas Blaty, Michael Malos, Thomas Palmrose, Stephen McGirr
BACKGROUND: The purpose of this case report is to present a rare finding of an intradural extramedullary hemangioblastoma of the cauda equina, with literature review. Spinal hemangioblastomas account for 1-5% of all spinal cord tumors. While spinal hemangioblastomas are rare, it is exceedingly rare to have a case of intradural extramedullary hemangioblastoma of the spine, especially in isolation without von-Hippel-Lindau syndrome. Only 20 previous cases have been reported. CASE DESCRIPTION: An 82-year-old male presented with MRI evidence of an intradural mass at the L4 spinal level...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29105011/modern-robot-assisted-radiosurgery-of-cerebral-angiomas-own-experiences-system-comparisons-and-comprehensive-literature-overview
#17
Thomas Feutren, Andres Huertas, Julia Salleron, René Anxionnat, Serge Bracard, Olivier Klein, Didier Peiffert, Valérie Bernier-Chastagner
Cerebral arteriovenous malformations (AVMs) are rare vascular lesions potentially responsible for substantial neurological morbidity and mortality. Over the past four decades, radiosurgery has become a valid therapeutic option for many patients with small intracranial AVMs, but reports describing the use of robotic stereotactic radiosurgery (SRS) are rare. The purposes of this study are to describe the efficacy and toxicity of robotic SRS for AVMs and to review the literature. The reports of 48 consecutive patients treated with SRS were reviewed...
November 5, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29064585/the-dosimetric-impact-of-the-prescription-isodose-line-idl-on-the-quality-of-robotic-stereotactic-radiosurgery-srs-plans
#18
Qianyi Xu, Jiajin Fan, Jimm Grimm, Tamara LaCouture, Sucha Asbell, Joo Han Park, Gregory Kubicek
PURPOSE: There is no consensus on the optimal prescription isodose line (IDL) in CyberKnife (CK) SRS. We designed a strategy to search for optimal CK plans at different levels of IDLs and investigated the dosimetric impact on the quality of CK plans. METHODS AND MATERIALS: The retrospective study consisted of 13 CK patients with 16 brain tumors. The mean volume and size of the tumors was 9.7±10.4 cc and 30.3±10.9 mm, respectively. Four shells were created at distances of 2-3 mm to 60 mm from the target...
October 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/29060494/predictive-local-receptive-fields-based-respiratory-motion-tracking-for-motion-adaptive-radiotherapy
#19
Yubo Wang, Sivanagaraja Tatinati, Liyu Huang, Kim Jeong Hong, Ghufran Shafiq, Kalyana C Veluvolu, Andy W H Khong
Extracranial robotic radiotherapy employs external markers and a correlation model to trace the tumor motion caused by the respiration. The real-time tracking of tumor motion however requires a prediction model to compensate the latencies induced by the software (image data acquisition and processing) and hardware (mechanical and kinematic) limitations of the treatment system. A new prediction algorithm based on local receptive fields extreme learning machines (pLRF-ELM) is proposed for respiratory motion prediction...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058682/small-composite-field-correction-factors-for-the-cyberknife-radiosurgery-system-clinical-and-pcsr-plans
#20
Eric Jessie Christiansen, Bryan Richard Muir, Jason Belec, Eric J Vandervoort
A formalism has been proposed for small and non-standard photon fields in which k<sup>fclin, fmsr</sup> <sub>Qclin, Qmsr</sub> correction factors are used to correct dosimeter response in small fields (static or composite) relative to that in a larger machine-specific reference (MSR) field. For composite fields, a plan-class specific reference (PCSR) field can also be defined, serving as an intermediate calibration field between the MSR and clinical fields within a certain plan-class...
October 23, 2017: Physics in Medicine and Biology
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