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https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#1
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28893302/comprehensive-target-geometric-errors-and-margin-assessment-in-stereotactic-partial-breast-irradiation
#2
Xin Zhen, Bo Zhao, Zhuoyu Wang, Robert Timmerman, Ann Spangler, Nathan Kim, Asal Rahimi, Xuejun Gu
BACKGROUND: Recently developed stereotactic partial breast irradiation (S-PBI) allows delivery of a high biologically potent dose to the target while sparing adjacent critical organs and normal tissue. With S-PBI tumoricidal doses, accurate and precise dose delivery is critical to achieve high treatment quality. This study is to investigate both rigid and non-rigid components of target geometric error and their corresponding margins in S-PBI and identify correlated clinical factors. METHODS: Forty-three early-stage breast cancer patients with implanted gold fiducial markers were enrolled in the study...
September 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28883763/cyberknife-stereotactic-radiosurgery-and-denosumab-for-giant-cell-tumour-of-the-skull-base-case-report
#3
Cuauhtemoc de la Peña, Jorge H Guajardo, Maria F Gonzalez, Miguel A Hinojosa, Erick Cardona
Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28883654/target-margin-design-for-real-time-lung-tumor-tracking-stereotactic-body-radiation-therapy-using-cyberknife-xsight-lung-tracking-system
#4
Zhi-Yong Yang, Yu Chang, Hong-Yuan Liu, Gang Liu, Qin Li
The objective of this study is to quantify the clinical accuracy of the Cyberknife Xsight Lung Tracking System (XLTS) in our center and calculate the PTV margin of XLTS treated lung tumors. Data from the treatment log files of 22 lung cancer patients treated with the CyberKnife XLTS were analyzed and the PTV margin was calculated. Segmentation, deformation, correlation, prediction and targeting errors were calculated from the log files of XLTS treatments. Two different methods were used to calculate anisotropic treatment margin...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875373/differentiating-brain-radionecrosis-from-tumour-recurrence-a-role-for-contrast-enhanced-ultrasound
#5
Luca Mattei, Francesco Prada, Marcello Marchetti, Paola Gaviani, Francesco DiMeco
Differentiating radionecrosis from tumour recurrence is a major issue in neuro-oncology. Conventional imaging is far from being validated as an alternative to histological assessment. We report the case of a patient operated on for suspected recurrence of brain metastasis 9 months after cyberknife radiosurgery. While magnetic resonance imaging showed strong enhancement of the lesion, intraoperative contrast-enhanced ultrasonography (CEUS) surprisingly did not-different from what is expected for brain metastases...
September 5, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28870966/robot-assisted-extracranial-stereotactic-radiotherapy-of-adrenal-metastases-in-oligometastatic-non-small-cell-lung-cancer
#6
Eren Celik, Robert Semrau, Christian Baues, Maike Trommer-Nestler, Wolfgang Baus, Simone Marnitz
AIM: The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with adrenal metastases in oligometastatic non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Between November 2012 and May 2015, fifteen patients with oligometastatic non-small cell lung cancer and adrenal metastases were treated with the Cyberknife® system. The primary endpoint was local control. RESULTS: The 1-year and 2-year local control rates were 60% and 46...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869401/clinical-outcomes-of-multileaf-collimator-based-cyberknife-for-spine-stereotactic-body-radiation-therapy
#7
Nalee Kim, Ho Lee, Jin Sung Kim, Jong Geal Baek, Chang Geol Lee, Sei Kyung Chang, Woong Sub Koom
OBJECTIVE: Stereotactic body radiotherapy (SBRT) for spinal metastases is becoming a prevalent therapeutic option. We aimed to evaluate the clinical feasibility and outcomes of the recently developed multileaf collimator (MLC)-based CyberKnife (CK-M) for spine SBRT. METHODS: We reviewed 119 patients of 144 cases with 229 lesions treated with CK between November 2014 and March 2016. The lesion features, dosimetric parameters, and clinical outcomes were compared between fixed cone collimator based CK (CK-F) and CK-M...
September 4, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28856078/participating-in-an-international-stereotactic-radiotherapy-patient-registry-the-establishment-of-data-collection-pathways
#8
Aylin Yahya, Eva Arneric, Elizabeth Kernutt, Fiona Baldacchino, Claire Haworth, Mary-Anne Kedda, Colin Tang, Sean Bydder, Tammy Corica
Aim To describe data collection pathways and practical challenges experienced by an academic comprehensive cancer centre aiming to record clinical data for patients being treated with a novel radiotherapy treatment modality. Methods Various options to capture data from all patients treated with the CyberKnife Robotic Radiosurgery System at Sir Charles Gairdner Hospital (SCGH) in Western Australia were explored. An international multicenter web-based secure database established and maintained by the Radiosurgery Society the RSSearch® Patient Registry was selected...
June 29, 2017: Curēus
https://www.readbyqxmd.com/read/28849326/-cyberknife%C3%A2-new-treatment-option-for-uveal-melanoma
#9
REVIEW
J M Mor, R Semrau, W Baus, K R Koch, F Schaub, C Cursiefen, S Marnitz, L M Heindl
BACKGROUND: CyberKnife® stereotactic radiosurgery is a new treatment option for uveal melanoma. OBJECTIVE: This review outlines the technique of robot-assisted CyberKnife® therapy, as well as the pros and cons in the treatment of uveal melanoma. METHODS: The study provides a PubMed literature review and own preliminary clinical experiences. RESULTS: CyberKnife® therapy for choroidal and ciliary body melanomas shows comparable results concerning local tumor control and overall survival matching those of conventional therapies...
August 28, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28821268/hypo-fractionated-sbrt-for-localized-prostate-cancer-a-german-bi-center-single-treatment-group-feasibility-trial
#10
Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S Merseburger, Alan Katz, Andreas Ziegler, Oliver Blanck, Jürgen Dunst
BACKGROUND: For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or with moderate hypo-fractionation over about 5 weeks. Recent advances in radiotherapy technology have made extreme hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer feasible, which has not yet been introduced as a standard treatment method in Germany...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28818094/radiotoxicity-in-robotic-radiosurgery-proposing-a-new-quality-index-for-optimizing-the-treatment-planning-of-brain-metastases
#11
Alexandra Hellerbach, Klaus Luyken, Mauritius Hoevels, Andreas Gierich, Daniel Rueß, Wolfgang W Baus, Martin Kocher, Maximilian I Ruge, Harald Treuer
BACKGROUND: As irradiated brain volume at 12 Gy (V12) is a predictor for radionecrosis, the purpose of the study was to develop a model for Cyberknife (CK) plans that is able to predict the lowest achievable V12 at a given tumor size and prescription dose (PD), and to suggest a new quality index regarding V12 for optimizing the treatment planning of brain metastases. METHOD: In our model V12 was approximated as a spherical shell around the tumor volume. The radial distance between tumor surface and the 12 Gy isodose line was calculated using an approximation of the mean dose gradient in that area...
August 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28812120/risk-adapted-robotic-stereotactic-body-radiation-therapy-for-inoperable-early-stage-non-small-cell-lung-cancer
#12
Susanne Temming, Martin Kocher, Erich Stoelben, Lars Hagmeyer, De-Hua Chang, Konrad Frank, Khosro Hekmat, Juergen Wolf, Wolfgang W Baus, Robert Semrau, Christian Baues, S Marnitz
PURPOSE: To evaluate efficacy and toxicity of stereotactic body radiation therapy (SBRT) with CyberKnife® (Accuray, Sunnyvale, CA, USA) in a selected cohort of primary, medically inoperable early-stage non-small cell lung cancer (NSCLC) patients. METHODS: From 2012 to 2016, 106 patients (median age 74 years, range 50-94 years) with primary NSCLC were treated with SBRT using CyberKnife®. Histologic confirmation was available in 87 patients (82%). For mediastinal staging, 92 patients (87%) underwent (18)F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET) and/or endobronchial ultrasound (EBUS)-guided lymph node biopsy or mediastinoscopy...
August 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28795547/-multiple-vertebral-hemangiomas-treated-simultaneously-with-cyberknife%C3%A2-technology
#13
R Harkati, M Baré, A Gulyban, D Dechambre, P Berkovic, P A Coucke
Haemangioma are benign, vasoformative lesions of endothelial origin. A minority of patients with a vertebral location are symptomatic with neck or back pain. Neurological deficits due to spinal cord compression are rare and mostly observed at the thoracic and upper lumbar spine. Treatment is indicated in case of relevant symptomatology. Several invasive treatment modalities exist such as surgery and intralesional injections, but radiotherapy is the most common treatment for painful lesions. We report a case of a patient with symptomatic bifocal vertebral haemangioma (d9, l3) associated with dorsal and lumbar pain treated simultaneously using a cyberknife® vsi system, with a significant reduction of pain and a limited toxicity...
July 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28791962/is-the-ptw-60019-microdiamond-a-suitable-candidate-for-small-field-reference-dosimetry
#14
Vanessa De Coste, Paolo Francescon, Marco Marinelli, Laura Masi, Lucia Paganini, Maria Pimpinella, Giuseppe Prestopino, Serenella Russo, Antonella Stravato, Claudio Verona, Gianluca Verona-Rinati
A systematic study of the PTW microDiamond (MD) output factors (OF) is reported, aimed at clarifying its response in small fields and investigating its suitability for small field reference dosimetry. Ten MDs were calibrated under (60)Co irradiation. OF measurements were performed in 6 MV photon beams by a CyberKnife M6, a Varian DHX and an Elekta Synergy linacs. Two PTW silicon diodes E (Si-D) were used for comparison. The results obtained by the MDs were evaluated in terms of absorbed dose to water determination in reference conditions and OF measurements, and compared to the results reported in the recent literature...
August 9, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28781810/effect-of-intratumoral-abscess-necrosis-on-the-outcome-for-head-and-neck-cancer-patients-treated-by-hypofractionated-stereotactic-re-irradiation-using-cyberknife%C3%A2
#15
Hideya Yamazaki, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Tadayuki Kotsuma, Ken Yoshida, Yasuo Yoshioka
The aim of the present study was to elucidate the effect of intratumoral abscess/necrosis (AN) on the outcome of patients with recurrent head and neck cancer (HNC) treated by stereotactic radiotherapy. The records of 67 patients treated with CyberKnife® in four institutes between August 2000 and July 2010 were reviewed. The frequency of AN appeared to be increased in younger postoperative patients with large ulcerative tumors. The AN(+) group exhibited a better initial response rate compared with the AN(-) group (64 vs...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28771143/equivalent-uniform-square-field-sizes-of-flattening-filter-free-photon-beams
#16
Wolfgang Lechner, Peter Kuess, Dietmar Georg, Hugo Palmans
Various types of treatment units, such as CyberKnife, TomoTherapy and C-arm linear accelerators (LINACs) are operated using flattening filter free (FFF) photon beams. Their reference dosimetry, however, is currently based on codes of practice that provide data which were primarily developed and tested for high-energy photon beams with flattening filter (WFF). The aim of this work was to introduce equivalent uniform square field sizes of FFF beams to serve as a basis of a unified reference dosimetry procedure applicable to all aforementioned FFF machines...
September 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749165/impact-of-robotic-ultrasound-image-guidance-on-plan-quality-in-sbrt-of-the-prostate
#17
Stefan Gerlach, Ivo Kuhlemann, Floris Ernst, Christoph Fürweger, Alexander Schlaefer
OBJECTIVES: Ultrasound provides good image quality, fast volumetric imaging, and is established for abdominal image guidance. Robotic transducer placement may facilitate intra-fractional motion compensation in radiation therapy. We consider integration with the CyberKnife and study whether the kinematic redundancy of a seven-degrees-of-freedom robot allows for acceptable plan quality for prostate treatments. METHODS: Reference treatment plans were generated for ten prostate cancer cases previously treated with the CyberKnife...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28740453/clinical-outcomes-of-130-patients-with-primary-and-secondary-lung-tumors-treated-with-cyberknife-robotic-stereotactic-body-radiotherapy
#18
Zsolt Levente Janvary, Nicolas Jansen, Veronique Baart, Magali Devillers, David Dechambre, Eric Lenaerts, Laurence Seidel, Nicole Barthelemy, Patrick Berkovic, Akos Gulyban, Ferenc Lakosi, Zsolt Horvath, Philippe A Coucke
BACKGROUND: Authors report clinical outcomes of patients treated with robotic stereotactic body radiotherapy (SBRT) for primary, recurrent and metastatic lung lesions. PATIENTS AND METHODS: 130 patients with 160 lesions were treated with Cyberknife SBRT, including T1-3 primary lung cancers (54%), recurrent tumors (22%) and pulmonary metastases (24%). The mean biologically equivalent dose (BED10Gy) was 151 Gy (72-180 Gy). Median prescribed dose for peripheral and central lesions was 3×20 Gy and 3×15 Gy, respectively...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28739211/investigating-the-surface-dose-contribution-of-intrafractional-kv-imaging-in-cyberknife-based-stereotactic-radiosurgery
#19
Abdulmecit Canbolat, Faruk Zorlu, Pervin Hurmuz, Mete Yeginer, Gokhan Ozyigit
CyberKnife treatment consists of hundreds of noncoplanar beams and numerous intrafractional images that can be taken during a single treatment fraction; thus, doses because of imaging should be considered in this technique. The aim of this study is to investigate the in-field and out-of-field surface doses induced from kV imaging system during stereotactic radiosurgery (SRS) treatment. The imaging-induced surface doses were measured at the center of the imaging field and within ±15-cm distance from the center in both craniocaudal and lateral directions...
July 21, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28716071/primary-solitary-plasmacytoma-of-the-liver-successful-treatment-with-fractionated-stereotactic-radiotherapy-cyberknife%C3%A2-a-case-report
#20
Thomas Chalopin, Isabelle Barillot, Jean-Paul Biny, Flavie Arbion, Marie Besson, Maria Santiago-Ribeiro, Eric Piver, Olivier Herault, Emmanuel Gyan, Lotfi Benboubker
BACKGROUND: Solitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia. To the best of our knowledge, very few cases have been reported without systemic disease. We reported a rare case of hepatic solitary plasmacytoma that successfully responded to fractionated stereotactic radiotherapy. CASE PRESENTATION: A 64-year-old white French man had monoclonal gammopathy of the immune globulin G lambda type; he developed a cholestasis and cytolysis with the discovery of a subscapular nodule...
July 18, 2017: Journal of Medical Case Reports
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