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https://www.readbyqxmd.com/read/29325918/bioactive-fraction-of-rhodiola-algida-against-chronic-hypoxia-induced-pulmonary-arterial-hypertension-and-its-anti-proliferation-mechanism-in-rats
#1
Xingmei Nan, Shanshan Su, Ke Ma, Xiaodong Ma, Ximeng Wang, Dongzhu Zhaxi, Rili Ge, Zhanqiang Li, Dianxiang Lu
BACKGROUND: Rhodiola algida has long been used to prevent acute and chronic altitude sickness. In our previous study, we screened for a bioactive fraction from R. algida. However, the effects and mechanisms of this bioactive fraction on chronic hypoxia-induced pulmonary arterial hypertension remain to be elucidated. OBJECTIVE: The aim of this study was to determine the effect of bioactive fraction from R. algida (ACRT) on chronic hypoxia-induced pulmonary arterial hypertension (HPAH) and to understand the possible mechanism of its pharmacodynamic actions...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29323739/fasudil-alleviates-pressure-overload-induced-heart-failure-by-activating-nrf2-mediated-antioxidant-responses
#2
Peng Guan, Yingran Liang, Na Wang
The RhoA/Rho-kinase cascade plays an important role in many aspects of cardiovascular function. This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats. Pressure overload induced heart failure was induced in SD rats by banding the abdominal aorta for 8 weeks. The rats were divided into four groups: Sham, TAC, TAC plus low dose of fasudil and TAC plus high dose of fasudil group. Low dose and high dose fasudil were 5 mg/kg/day and 10 mg/kg/day respectively...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29321946/clinical-and-radiologic-considerations-for-idiopathic-superior-mesenteric-artery-syndrome
#3
Mina S Makary, Anand Rajan, Anthony M Aquino, Suresh K Chamarthi
Superior mesenteric artery (SMA) syndrome often occurs in the setting of rapid weight loss and scoliosis corrective spinal surgery. A reduction of fat around the third part of the duodenum can predispose the duodenum to compression and obstruction by the SMA as it emerges from the abdominal aorta. In this report, we describe this underdiagnosed condition in a previously healthy young female presenting with progressive post-prandial emesis, non-specific abdominal pain, and weight loss. A critical review of this disease process is explored to highlight pathology, imaging characteristics, and essential alternative diagnostic considerations...
November 5, 2017: Curēus
https://www.readbyqxmd.com/read/29321388/suppression-of-abdominal-aortic-aneurysm-formation-in-mice-by-teneligliptin-a-dipeptidyl-peptidase-4-inhibitor
#4
Yusuke Takahara, Tomotake Tokunou, Toshihiro Ichiki
AIM: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels through inhibition of incretin degradation, which stimulates insulin secretion. Recent studies reported that DPP-4 inhibitors suppressed atherogenesis in apolipoprotein E-knockout (ApoEKO) mice. In this study, we investigated whether teneligliptin, a DPP-4 inhibitor, affects the development of abdominal aortic aneurysms (AAA) in ApoEKO mice. METHODS: ApoEKO mice were fed a high-fat diet (HFD) and infused with angiotensin (Ang) II by osmotic mini pumps for 4 weeks to induce AAA with (DPP-4i group) or without (control group) teneligliptin administered orally from 1 week before HFD and Ang II infusion to the end of the experiment...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29321037/acute-aortoiliac-occlusive-disease-during-percutaneous-transluminal-angioplasty-in-the-setting-of-st-elevation-myocardial-infarction-a-case-report
#5
Anthony H Kashou, Nabil Braiteh, Ali Zgheib, Hisham E Kashou
BACKGROUND: Aortoiliac occlusive disease, which is also referred to as Leriche syndrome, is a chronic atherosclerotic occlusive disease that occurs at the level of the aortic bifurcation. It is often thought to present with a triad of clinical symptoms: (1) intermittent lower extremity vascular claudication, (2) impotence, and (3) weak/absent femoral pulses. CASE PRESENTATION: We report a case of a 47-year-old Caucasian woman who presented with an acute inferior ST-elevation myocardial infarction...
January 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29317965/perioperative-anesthetic-management-of-a-case-of-rare-ectopic-pheochromocytoma
#6
Aihua Jiang, Haiqiao Zhang, Xiaofei Liu, Huishan Zhao
We report an unusual case of pheochromacytoma and investigate the perioperative anesthetic management methods for giant abdominal aortic pheochromocytoma. We analyzed and summarized the recent clinical anesthetic management and experience in the hospital for a giant abdominal aortic pheochromocytoma, with the size of 20 × 14 × 5 cm. Under general anesthesia combined with TAPB, the resection of the giant abdominal aorta pheochromocytoma was successfully completed, and the patient was cured and discharged. Well planned and careful management resulted in patient with stable blood pressure, blood volume and cardiac functions, free from complications...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29316552/arteriovenous-sphingosine-1-phosphate-differences-across-selected-organs-of-the-rat
#7
Monika Książek, Urszula Baranowska, Adrian Chabowski, Marcin Baranowski
BACKGROUND/AIMS: Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid that is found in high concentration in plasma. The majority of plasma S1P is transported bound to HDL and albumin. Although the major sources of circulating S1P have been identified, it remains obscure what is the contribution of different organs/tissues to S1P homeostasis in plasma. Answering this question was the major aim of the present study. METHODS: The experiment was performed on male Wistar rats from whom blood samples were taken from either: 1) femoral vein, right ventricle of the heart, and abdominal aorta (n=15) or 2) hepatic vein, portal vein, and abdominal aorta (n=11)...
December 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29313113/epidemiology-and-contemporary-management-of-abdominal-aortic-aneurysms
#8
Brant W Ullery, Richard L Hallett, Dominik Fleischmann
Abdominal aortic aneurysm (AAA) is most commonly defined as a maximal diameter of the abdominal aorta in excess of 3 cm in either anterior-posterior or transverse planes or, alternatively, as a focal dilation ≥ 1.5 times the diameter of the normal adjacent arterial segment. Risk factors for the development of AAA include age > 60, tobacco use, male gender, Caucasian race, and family history of AAA. Aneurysm growth and rupture risk appear to be associated with persistent tobacco use, female gender, and chronic pulmonary disease...
January 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29310402/a-rare-variation-of-celiac-trunk-and-hepatic-artery-complicating-pancreaticoduodenectomy-a-case-report-and-literature-review
#9
Zhou Ye, Song Ye, Dongkai Zhou, Shusen Zheng, Weilin Wang
RATIONALE: Anatomical variations of the celiac trunk and the hepatic artery are of considerable importance in hepatopancreatobiliary surgery, liver transplants, and radiological abdominal interventions. PATIENT CONCERNS: Here, we report a 57-year-old man with 2 weeks of painless progressive jaundice. Preoperative imaging and cytology brush results suggested an ampullary tumor and common hepatic artery anomaly (CTA) was reported. The patient underwent pancreaticoduodenectomy (PD)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310347/radical-antegrade-modular-pancreatosplenectomy-for-adenocarcinomaof-the-body-of-the-pancreas-in-a-patient-with-portal-annular-pancreas-aberrant-hepatic-artery-and-absence-of-the-celiac-trunk-a-case-report
#10
Hao Yuan, Pengfei Wu, Jianmin Chen, Zipeng Lu, Lei Chen, Jishu Wei, Feng Guo, Baobao Cai, Jie Yin, Dong Xu, Kuirong Jiang, Yi Miao
RATIONALE: Portal annular pancreas is a rare anatomic variation, where the uncinated process of the pancreas connects with the dorsal pancreas and the pancreas tissue encases the portal vein (PV), superior mesenteric vein (SMV) or splenic vein (SV). Malignancies are quite uncommon in the patients, who have an annular pancreas especially portal annular pancreas. Ectopic common hepatic artery and absence of the celiac trunk (CT) are the other infrequent abnormalities. PATIENT CONCERNS: A 74-year-old man suffered from upper abdominal and back pain...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307934/fistula-between-the-abdominal-aorta-and-a-retroaortic-left-renal-vein-a-rare-complication-of-abdominal-aortic-aneurysm
#11
Leonor Garbin Savarese, Henrique Simão Trad, Edwaldo Edner Joviliano, Valdair Francisco Muglia, Jorge Elias Junior
No abstract text is available yet for this article.
November 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/29304096/exogenous-bmp7-in-aortae-of-rats-with-chronic-uremia-ameliorates-expression-of-profibrotic-genes-but-does-not-reverse-established-vascular-calcification
#12
Eva Gravesen, Maria Lerche Mace, Anders Nordholm, Jacob Hofman-Bang, Keith Hruska, Carsten Haagen Nielsen, Andreas Kjær, Klaus Olgaard, Ewa Lewin
Hyperphosphatemia and vascular calcification are frequent complications of chronic renal failure and bone morphogenetic protein 7 (BMP7) has been shown to protect against development of vascular calcification in uremia. The present investigation examined the potential reversibility of established uremic vascular calcification by treatment of uremic rats with BMP7. A control model of isogenic transplantation of a calcified aorta from uremic rats into healthy littermates examined whether normalization of the uremic environment reversed vascular calcification...
2018: PloS One
https://www.readbyqxmd.com/read/29299980/effects-of-atmospheric-pressure-dynamics-on-abdominal-aortic-aneurysm-rupture-onset
#13
Dragan Opacic, Nikola Ilic, Milos Sladojevic, Patrick Schönleitner, Dragan Markovic, Dusan Kostic, Lazar Davidovic
BACKGROUND: The effect of atmospheric pressure (AP) on the onset of abdominal aorta aneurysm rupture (RAAA) remains an unanswered question. We have investigated the seasonal variation and the effect of AP dynamics on RAAA by analysing the largest series of intraoperatively confirmed RAAA. PATIENTS AND METHODS: To realize this study we have performed a retrospective analysis of 546 patients with RAAA, operated within 503 days at the Clinic for vascular and endovascular surgery CCS between 1...
January 4, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29299627/3d-vascular-anatomy-of-the-presacral-space-impact-of-age-and-adiposity
#14
Alexander A Berger, Steven Abramowitch, Pamela A Moalli
INTRODUCTION AND HYPOTHESIS: Defining patient characteristics that alter vascular anatomy at the sacrum is critical for avoiding life-threatening bleeding at the time of sacrocolpopexy. We tested the hypothesis that in thinner/older women, the bifurcations of the aorta and inferior vena cava (IVC) are lower relative to S1 resulting in less space accessible for suture/mesh placement, placing this group at increased risk of major vascular injury. METHODS: In a retrospective cross-sectional study, CT scans were used to make 2D measurements and a 3D model of the aorta/IVC, intervertebral disc space, and bony anatomy using segmentation and modeling software...
January 3, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29290476/feasibility-study-of-a-novel-thoraco-abdominal-aortic-hybrid-device-spider-graft-in-a-translational-pig-model
#15
REVIEW
Eike S Debus, Tilo Kölbel, Anna Duprée, Günter Daum, Harleen L Sandhu, Daniel Manzoni, Sabine H Wipper
BACKGROUND: The hybrid SPIDER-graft consists of a proximal descending aortic stent graft and a conventional six branched Dacron graft for open abdominal aortic repair. Technical feasibility with regard to avoiding thoracotomy and extracorporeal circulation (ECC) during thoraco-abdominal aortic hybrid repair and peri-procedural safety of this novel device are unknown. MATERIAL AND METHODS: This was a feasibility and safety study in domestic pigs (75-85 kg). The abdominal aorta including iliac bifurcation, left renal artery, and visceral arteries were exposed via retroperitoneal access...
December 28, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29286474/mouse-model-for-pancreas-transplantation-using-a-modified-cuff-technique
#16
Benno Cardini, Rupert Oberhuber, Sven R Hein, Rebecca Eiter, Martin Hermann, Markus Kofler, Stefan Schneeberger, Gerald Brandacher, Manuel Maglione
Mouse models have several advantages in transplantation research, including easy handling, a variety of genetically well-defined strains, and the availability of the widest range of molecular probes and reagents to perform in vivo as well as in vitro studies. Based on our experience with various murine transplantation models, we developed a heterotopic pancreas transplantation model in mice with the intent to analyze mechanisms underlying severe ischemia reperfusion injury-associated early graft damage. In contrast to previously described techniques using suture techniques, herein we describe a new procedure using a non-suture cuff technique...
December 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29285566/suppression-of-aortic-expansion-and-contractile-recovery-in-a-rat-abdominal-aortic-aneurysm-model-by-biodegradable-gelatin-hydrogel-sheet-incorporating-basic-fibroblast-growth-factor
#17
Norikazu Kawai, Hisashi Iwata, Katsuya Shimabukuro, Narihiro Ishida, Hiroki Ogura, Etsuji Umeda, Kiyoshi Doi
Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague-Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (n = 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion...
December 28, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29284386/current-status-and-perspectives-on-pharmacologic-therapy-for-abdominal-aortic-aneurysm
#18
Koichi Yoshimura, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa, Kimikazu Hamano
Abdominal aortic aneurysm (AAA), a common disease involving the segmental expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA are currently limited to surgical repair to prevent catastrophic rupture. Non-surgical approaches, particularly pharmacotherapy, are lacking for the treatment of AAA. Here, we review both basic and clinical studies and discuss the current challenges to developing medical therapy that reduces AAA progression. Studies using animal models of AAA progression and human AAA explant cultures have identified several potential targets for preventing AAA growth...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29279149/noise-characteristics-of-virtual-monoenergetic-images-from-a-novel-detector-based-spectral-ct-scanner
#19
Kevin Kalisz, Negin Rassouli, Amar Dhanantwari, David Jordan, Prabhakar Rajiah
AIM: To evaluate the noise characteristics of virtual monoenergetic images (VMI) obtained from a recently introduced dual-layer detector-based spectral CT (SDCT), both in a phantom and patients. MATERIALS AND METHODS: A cylindrical Catphan® 600 phantom (The Phantom Library, Salem NY, USA) was scanned using the SDCT. Image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were measured in VMI from 40 to 200keV as well as conventional 120 kVp images...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29277037/environmental-pollutant-hexachlorobenzene-induces-hypertension-in-a-rat-model
#20
Rocío Castilla, Agustín Asuaje, Stéphanie Rivière, Caimi Giselle Romero, Pedro Martín, Gabriel Cao, Diana Kleiman de Pisarev, Verónica Milesi, Laura Alvarez
Hexachlorobenzene (HCB) is a dioxin-like environmental pollutant, widely distributed in the environment. New research links exposure to high levels of persistent organic environmental toxicants to cardiovascular disease, however little is known about the effect of HCB on vascular function and on blood pressure. The purpose of the present study was to evaluate biochemical and cardiovascular changes resulting from subchronic HCB exposure. Adult female Sprague-Dawley rats were treated with vehicle or HCB (5 or 500 mg/kg b...
November 22, 2017: Chemosphere
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