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https://www.readbyqxmd.com/read/29777233/visceral-adiposity-and-high-adiponectin-levels-are-associated-with-the-prevalence-of-pancreatic-cystic-lesions
#1
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Takeharu Yoshikawa, Kei Saito, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Naoto Hayashi, Kazuhiko Koike
OBJECTIVES: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. METHODS: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29776376/hybrid-surgery-in-treatment-of-pulmonary-sequestration-with-abdominal-aorta-feeding-vessel-a-case-report
#2
Haining Zhou, Shoujun Tang, Quanshui Fu, Li Yu, Lunxu Liu
BACKGROUND: Pulmonary sequestration is a rare congenital pulmonary dysplasia, which requires surgical resection (either via open thoracotomy or video-assisted thoracoscopic surgery [VATS] or via endoluminal occlusion of the abnormal feeding vessel). CASE PRESENTATION: We described a 51-year-old female patient with a history of recurrent cough and repeated pneumonia. She was referred to our hospital for further work-up of pulmonary sequestration. We performed a hybrid surgery (i...
May 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29772287/probiotics-and-nutraceuticals-as-a-new-frontier-in-obesity-prevention-and-management
#3
N Kobyliak, T Falalyeyeva, N Boyko, O Tsyryuk, T Beregova, L Ostapchenko
INTRODUCTION: The beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats. METHODS: Totally, 75 rats divided into five groups were included (n=15, in each)...
May 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29769704/effect-of-protocatechuic-acid-on-insulin-responsiveness-and-inflammation-in-visceral-adipose-tissue-from-obese-individuals-possible-role-for-ptp1b
#4
Paulina Ormazabal, Beatrice Scazzocchio, Rosaria Varì, Carmela Santangelo, Massimo D'Archivio, Gianfranco Silecchia, Annunziata Iacovelli, Claudio Giovannini, Roberta Masella
BACKGROUND/OBJECTIVES: The occurrence of chronic inflammation in visceral adipose tissue (VAT) in obese subjects precipitates the development of insulin resistance and type 2 diabetes (T2D). Anthocyanins and their main metabolite protocatechuic acid (PCA) have been demonstrated to stimulate insulin signaling in human adipocytes. The aim of this study was to investigate whether PCA is able to modulate insulin responsiveness and inflammation in VAT from obese (OB) and normal weight (NW) subjects...
May 16, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29769150/adipose-tissue-uncoupling-protein-1-levels-and-function-are-increased-in-a-mouse-model-of-developmental-obesity-induced-by-maternal-exposure-to-high-fat-diet
#5
E Bytautiene Prewit, C Porter, M La Rosa, N Bhattarai, H Yin, P Gamble, T Kechichian, L S Sidossis
With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exposed to prenatal obesity. Female CD-1 mice were fed a high-fat (HF) or standard-fat (SF) diet for 3 months before breeding. After weaning, all pups were placed on SF. UCP1 mRNA and protein levels were quantified using quantitative real-time PCR and Western blot analysis, respectively, in brown (BAT), subcutaneous (SAT) and visceral (VAT) adipose tissues at 6 months of age...
May 17, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29768086/visual-associations-to-retrieve-episodic-memory-across-healthy-elderly-mild-cognitive-impairment-and-patients-with-alzheimer-s-disease
#6
Sascha R A Meyer, Jos F M De Jonghe, Ben Schmand, Rudolf W H M Ponds
Episodic memory tests need to determine the degree to which patients with moderate to severe memory deficits can still benefit from retrieval support. Especially in the case of Alzheimer's disease (AD), this may support health care to be more closely aligned with patients' memory capacities. We investigated whether the different measures of episodic memory of the Visual Association Test-Extended (VAT-E) can provide a more detailed and informative assessment on memory disturbances across a broad range of cognitive decline, from normal to severe impairment as seen in AD, by examining differences in floor effects...
May 16, 2018: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/29764718/metabolic-syndrome-associates-with-left-atrial-dysfunction
#7
K Nyman, M Granér, M O Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, M S Nieminen, M-R Taskinen, N Lundbom, K Lauerma
BACKGROUND AND AIMS: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS AND RESULTS: Myocardial and hepatic triglyceride contents were measured with 1.5T 1 H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS...
February 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29763423/from-one-incision-to-one-port-the-surgical-technique-and-the-evolution-of-segmentectomy-in-patients-with-pulmonary-tuberculosis
#8
Yau-Lin Tseng, Chao-Chun Chang, Ying-Yuan Chen, Yi-Sheng Liu, Lili Cheng, Jia-Ming Chang, Ming-Ho Wu, Yi-Ting Yen
OBJECTIVES: We retrospectively reviewed the evolution of segmentectomy for pulmonary tuberculosis (TB) and the feasibility of multi- and single-incision video-assisted thoracoscopic segmentectomy. METHODS: Of 348 patients undergoing surgery for TB, the medical records of 121 patients undergoing segmentectomy between January 1996 and November 2015 were reviewed. Clinical information and computed tomography (CT) image characteristics were investigated and analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29760023/improving-prediction-of-dementia-in-primary-care
#9
Susan Jongstra, Willem A van Gool, Eric P Moll van Charante, Jan-Willem van Dalen, Lisa S M Eurelings, Edo Richard, Suzanne A Ligthart
PURPOSE: The Mini-Mental State Examination (MMSE) is one of the most widely used instruments to screen for cognitive deficits; however, this instrument alone is not sensitive enough to detect early symptoms of dementia. We aimed to investigate whether additionally using the Visual Association Test (VAT) improves the predictive value of the MMSE score for development of dementia. METHODS: Analyses were based on data from 2,690 primary care patients aged 70 to 78 years who participated in the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial...
May 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29757824/improvements-in-key-cardiopulmonary-exercise-testing-variables-following-cardiac-rehabilitation-in-patients-with-coronary-artery-disease
#10
Dejana Popovic, Nikhil Kumar, Sundeep Chaudhry, Akshay Bagai, Ross Arena, Naresh Kumar
PURPOSE: Improvements in cardiorespiratory fitness (VO2peak) post-cardiac rehabilitation (post-CR) are used to gauge therapeutic efficacy. The aim of the present study was to assess the effect of supervised CR on other cardiopulmonary exercise testing (CPX) variables, specifically those that reflect ventilatory efficiency and VO2 changes in relation to changes in work rate (WR). METHODS: Patients (n = 142; mean age 63 ± 9 y; 23% female) with coronary artery disease (CAD) participated in supervised CR for 3 to 6 mo completing 60 ± 17 sessions (range: 32-96 sessions), with intensity derived from the baseline CPX...
May 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29756062/effect-of-preoperative-gabapentin-and-acetaminophen-on-opioid-consumption-in-video-assisted-thoracoscopic-surgery-a-retrospective-study
#11
Robert Qiu, Albert C Perrino, Holly Zurich, Nitin Sukumar, Feng Dai, Wanda Popescu
Background: Patients undergoing video-assisted thoracoscopic surgery (VATS) are particularly vulnerable to opioid-induced sedation and hypoventilation. Accordingly, reducing opioid consumption in these patients is a primary goal of multimodal analgesic regimens. Although administration of preoperative gabapentin and acetaminophen has been shown to decrease postoperative opioid consumption in other surgeries, this approach has not been studied in VATS lobectomy. Our objective was to examine the impact of the addition of preoperative gabapentin and acetaminophen to a VATS lobectomy multimodal analgesic plan on postoperative opioid consumption, nausea/vomiting, and sedation...
April 2018: Romanian Journal of Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29755099/-the-role-of-video-assisted-thoracic-surgery-in-multimodality-therapy
#12
Yugo Tanaka, Takanori Matsumoto, Yoshimasa Maniwa
Minimally invasive surgery is being widely performed for the management of lung cancers owing to rapid technological advances in surgical devices and techniques. In recent times, because chemotherapy and radiotherapy have both become less invasive treatment strategies, therapeutic opportunities for the use of multimodality therapy have been increasing. Minimally invasive surgery is an important component that requires additional improvements to derive the complete benefit of multimodality therapy. We have been actively performing video-assisted thoracic surgery(VATS) for the management of advanced lung cancers, as well as early lung cancers to reduce surgical stress in our patients, thereby enhancing the scope of multimodality therapy...
April 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29754289/the-novel-adipokine-wisp1-associates-with-insulin-resistance-and-impairs-insulin-action-in-human-myotubes-and-mouse-hepatocytes
#13
Tina Hörbelt, Christopher Tacke, Mariya Markova, Daniella Herzfeld de Wiza, Frederique Van de Velde, Marlies Bekaert, Yves Van Nieuwenhove, Silke Hornemann, Maria Rödiger, Nicole Seebeck, Elisabeth Friedl, Wenke Jonas, G Hege Thoresen, Oliver Kuss, Anke Rosenthal, Volker Lange, Andreas F H Pfeiffer, Annette Schürmann, Bruno Lapauw, Natalia Rudovich, Olga Pivovarova, D Margriet Ouwens
AIMS/HYPOTHESIS: Wingless-type (Wnt) inducible signalling pathway protein-1 (WISP1) has been recently identified as a proinflammatory adipokine. We examined whether WISP1 expression and circulating levels are altered in type 2 diabetes and whether WISP1 affects insulin signalling in muscle cells and hepatocytes. METHODS: Serum and visceral adipose tissue (VAT) biopsies, for analysis of circulating WISP1 levels by ELISA and WISP1 mRNA expression by real-time quantitative RT-PCR, were collected from normal-weight men (control group, n = 33) and obese men with (n = 46) and without type 2 diabetes (n = 56) undergoing surgery...
May 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29753139/a-review-on-fabricating-tissue-scaffolds-using-vat-photopolymerization
#14
REVIEW
Nicholas A Chartrain, Christopher B Williams, Abby R Whittington
Vat Photopolymerization (stereolithography, SLA), an Additive Manufacturing (AM) or 3D printing technology, holds particular promise for the fabrication of tissue scaffolds for use in regenerative medicine. Unlike traditional tissue scaffold fabrication techniques, SLA is capable of fabricating designed scaffolds through the selective photopolymerization of a photopolymer resin on the micron scale. SLA offers unprecedented control over scaffold porosity and permeability, as well as pore size, shape, and interconnectivity...
May 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29751203/effect-of-adipose-tissue-volume-on-prognosis-in-patients-with-non-small-cell-lung-cancer
#15
Jeong Won Lee, Ho Sung Lee, Ju Ock Na, Sang Mi Lee
OBJECTIVE: This study evaluated the relationship between adipose tissue volume and survival in patients with non-small cell lung cancer (NSCLC). METHODS: We retrospectively included 171 NSCLC patients who underwent staging 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and subsequent curative surgical resection or definite chemoradiotherapy. Maximum standardized uptake value (SUV) of lung cancer normalized by lean body mass (SULmax) and volume and mean SUV of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were derived from PET/CT images...
May 4, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29750932/bilateral-posterior-mediastinal-primary-myelolipoma
#16
Ishan Goel, Parul Kaushik, Rama Anand
Myelolipoma(ML) is an uncommon benign mesenchymal tumor consisting of mature adipocytes and hemopoietic elements mostly found in adrenal glands. Bilateral posterior mediastinal primary myelolipoma presents extremely rarely and only 11 such occurrences have been previously described. With no definite symptoms, pathological evaluation is essential for diagnosis. Here the authors present a case of a 63-year old man diagnosed with bilateral posterior mediastinal primary myelolipoma on basis of radiological findings who underwent surgical resection via video-assisted thoracic surgery (VATS)...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29750269/analytical-determination-of-nicotine-and-tar-levels-in-various-dokha-and-shisha-tobacco-products
#17
Bassam Mahboub, Ayesha Begum Mohammad, Ayssar Nahlé, Mayank Vats, Omar Al Assaf, Hamdan Al-Zarooni
In the Middle East, there is no precise data and literature on tobacco-based products, such as dokha and shisha. The proposed study aims to quantify the levels of nicotine and tar in different kinds of dokha and shisha products that are sold in the local marketplace. The amount of nicotine in dokha and shisha products can be quantitatively determined using a combination of the "kissling" and "silicotungstic acid" method proposed by Robert M. Chapin. The tar residue from the smoke sample was collected on a glass wool placed before the stopcock (tap) of a separatory funnel as the smoke passes through the inlet of an electronically controlled vacuum pump...
May 10, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29747897/short-hookwire-placement-under-imaging-guidance-before-thoracic-surgery-a-review
#18
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, Y Masaoka, M Uka, H Gobara, S Toyooka, S Kanazawa
During video-assisted thoracic surgery (VATS), localization is sometimes needed to detect a target lesion that is too small and/or too far from the pleura. In 1995, Kanazawa et al. developed short hookwire and suture system. Since then, this system has been placed often for selected targets before VATS in Japan. This short hookwire and suture system is a representative preoperative localization method and the placement procedure is well-established. Its placement success rates are very high (range: 97.6%-99...
May 7, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29745794/visceral-adipose-tissue-tracks-more-closely-with-metabolic-dysfunction-than-intrahepatic-triglyceride-in-non-diabetic-lean-asians
#19
Cherlyn Ding, Zhiling Chan, Yu Chung Chooi, John Choo, Suresh Anand Sadananthan, Navin Michael, S Sendhil Velan, Melvin Khee-Shing Leow, Faidon Magkos
BACKGROUND: Increased visceral adipose tissue (VAT) and intrahepatic triglyceride (IHTG) are important risk factors for the development of type 2 diabetes in obese subjects. The relative contribution of these ectopic fat depots to cardiometabolic risk differs between populations, depends on the degree of obesity and the level of cardiorespiratory fitness, and is difficult to dissect because VAT and IHTG typically co-vary. The aim of this study was to evaluate the effect of an isolated increase in VAT or IHTG on insulin sensitivity and insulin secretion in apparently healthy normal-weight Asian subjects...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29740737/comparison-of-the-analgesic-effects-of-modified-continuous-intercostal-block-and-paravertebral-block-under-surgeon-s-direct-vision-after-video-assisted-thoracic-surgery-a-randomized-clinical-trial
#20
Yuka Kadomatsu, Shoichi Mori, Harushi Ueno, Mika Uchiyama, Kenji Wakai
OBJECTIVE: Clinical evidence comparing paravertebral (PVB) and continuous intercostal nerve (ICB) blocks for pain management post video-assisted thoracic surgery (VATS) is limited. This study confirms the analgesic effect of ICB using two catheters is not inferior to that of PVB under direct vision. METHODS: Fifty patients who underwent VATS lobectomy from July 2015 to March 2016 were prospectively recruited and randomly assigned to PVB and ICB groups. Postoperative pain was assessed using the visual analog scale (VAS)...
May 8, 2018: General Thoracic and Cardiovascular Surgery
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