Niek F Dirks, Wendy P J den Elzen, Jacquelien J Hillebrand, Heleen I Jansen, Edwin Ten Boekel, Jacoline Brinkman, Madelon M Buijs, Ayse Y Demir, Ineke M Dijkstra, Silvia C Endenburg, Paula Engbers, Jeannette Gootjes, Marcel J W Janssen, Wilhelmina H A Kniest-de Jong, Maarten B Kok, Stephan Kamphuis, Adrian Kruit, Etienne Michielsen, Albert Wolthuis, Anita Boelen, Annemieke C Heijboer
OBJECTIVES: Correct interpretation of thyroid function tests relies on correct reference intervals (RIs) for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). ISO15189 mandates periodic verification of RIs, but laboratories struggle with cost-effective approaches. We investigated whether indirect methods (utilizing historical laboratory data) could replace the direct approach (utilizing healthy reference individuals) and compared results with manufacturer-provided RIs for TSH and FT4...
January 12, 2024: Clinical Chemistry and Laboratory Medicine: CCLM