Jimmy Stalin, Oriana Coquoz, Rachel Jeitziner Marcone, Stephane Jemelin, Nina Desboeufs, Mauro Delorenzi, Marcel Blot-Chabaud, Beat A Imhof, Curzio Ruegg
The melanoma cell adhesion molecule, shed from endothelial and cancer cells, is a soluble growth factor that induces tumor angiogenesis and growth. However, the molecular mechanism accounting for its generation in a tumor context is still unclear. To investigate this mechanism, we performed in vitro experiments with endothelial/cancer cells, gene expression analyses on datasets from human colorectal tumor samples, and applied pharmacological methods in vitro/in vivo with mouse and human colorectal cancer cells...
November 30, 2023: Biomedicines