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https://www.readbyqxmd.com/read/29049968/a-novel-eulerian-approach-for-modelling-cyanobacteria-movement-thin-layer-formation-and-recurrent-risk-to-drinking-water-intakes
#1
Mouhamed Ndong, David Bird, Tri Nguyen Quang, René Kahawita, David Hamilton, Marie Laure de Boutray, Michèle Prévost, Sarah Dorner
Toxic cyanobacteria (CB) blooms are being reported in an increasing number of water bodies worldwide. As drinking water (DW) treatment can be disrupted by CB, in addition to long term management plans, short term operational decision-making tools are needed that enable an understanding of the temporal variability of CB movement in relation to drinking water intakes. In this paper, we propose a novel conservative model based on a Eulerian framework and compare results with data from CB blooms in Missisquoi Bay (Québec, Canada)...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29045731/the-chimpanzee-model-of-viral-hepatitis-advances-in-understanding-the-immune-response-and-treatment-of-viral-hepatitis
#2
Robert E Lanford, Christopher M Walker, Stanley M Lemon
Chimpanzees (Pan troglodytes) have contributed to diverse fields of biomedical research due to their close genetic relationship to humans and in many instances due to the lack of any other animal model. This review focuses on the contributions of the chimpanzee model to research on hepatitis viruses where chimpanzees represented the only animal model (hepatitis B and C) or the most appropriate animal model (hepatitis A). Research with chimpanzees led to the development of vaccines for HAV and HBV that are used worldwide to protect hundreds of millions from these diseases and, where fully implemented, have provided immunity for entire generations...
October 17, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29038906/pcsk9-mutations-in-familial-hypercholesterolemia-from-a-groundbreaking-discovery-to-anti-pcsk9-therapies
#3
REVIEW
Petra El Khoury, Sandy Elbitar, Youmna Ghaleb, Yara Abou Khalil, Mathilde Varret, Catherine Boileau, Marianne Abifadel
PURPOSE OF REVIEW: In 2003, Abifadel et al. (Nat. Genet. 34:154-156, 2003) identified PCSK9, encoding proprotein convertase subtilisin/kexin type 9, as the third causal gene for autosomal dominant hypercholesterolemia. This review focuses on the main steps from this major breakthrough in familial hypercholesterolemia (FH) to the latest clinical trials with the anti-PCSK9 antibodies. RECENT FINDINGS: The year 2015 was remarkable in cardiovascular disease through the field of cholesterol...
October 17, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29037033/carboxymethylcellulose-mediates-the-transport-of-carbon-nanotubes-magnetite-nanohybrid-aggregates-in-water-saturated-porous-media
#4
Dengjun Wang, Chang Min Park, Arvid Masud, Nirupam Aich, Chunming Su
Carbon-metal oxide nanohybrids (NHs) are increasingly recognized as the next-generation, promising group of nanomaterials for solving emerging environmental issues and challenges. This research, for the first time, systematically explored the transport and retention of carbon nanotubes-magnetite (CNT-Fe3O4) NH aggregates in water-saturated porous media under environmentally relevant conditions. A macromolecule modifier, carboxymethylcellulose (CMC) was employed to stabilize the NHs. Our results show that transport of the magnetic CNT-Fe3O4 NHs was lower than that of non-magnetic CNT due to larger hydrodynamic sizes of NHs (induced by magnetic attraction) and size-dependent retention in porous media...
October 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29036714/accounting-for-technical-noise-in-differential-expression-analysis-of-single-cell-rna-sequencing-data
#5
Cheng Jia, Yu Hu, Derek Kelly, Junhyong Kim, Mingyao Li, Nancy R Zhang
Recent technological breakthroughs have made it possible to measure RNA expression at the single-cell level, thus paving the way for exploring expression heterogeneity among individual cells. Current single-cell RNA sequencing (scRNA-seq) protocols are complex and introduce technical biases that vary across cells, which can bias downstream analysis without proper adjustment. To account for cell-to-cell technical differences, we propose a statistical framework, TASC (Toolkit for Analysis of Single Cell RNA-seq), an empirical Bayes approach to reliably model the cell-specific dropout rates and amplification bias by use of external RNA spike-ins...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29034826/voice-of-the-clinician-the-case-of-an-australian-health-system
#6
Mark J Lock, Amber L Stephenson, Jill Branford, Jonathan Roche, Marissa S Edwards, Kathleen Ryan
Purpose The Voice of the Clinician project commenced during an era when practitioner burnout, dissatisfaction, and turnover became an increasingly global health workforce concern. One key problem is clinical staff not being empowered to voice their concerns to decision-makers, as was found in this case study of an Australian public health organization. The following research question informed the present study: What is a better committee system for clinician engagement in decision-making processes? The paper aims to discuss this issue...
September 18, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29033954/setaria-comes-of-age-meeting-report-on-the-second-international-setaria-genetics-conference
#7
Chuanmei Zhu, Jiani Yang, Christine Shyu
Setaria viridis is an emerging model for cereal and bioenergy grasses because of its short stature, rapid life cycle and expanding genetic and genomic toolkits. Its close phylogenetic relationship with economically important crops such as maize and sorghum positions Setaria as an ideal model system for accelerating discovery and characterization of crop genes that control agronomically important traits. The Second International Setaria Genetics Conference was held on March 6-8, 2017 at the Donald Danforth Plant Science Center, St...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29032636/tokyo-guidelines-2018-diagnostic-criteria-and-severity-grading-of-acute-cholecystitis-with-videos
#8
Masamichi Yokoe, Jiro Hata, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Go Wakabayashi, Kazuto Kosaka, Itaru Endo, Daniel J Deziel, Fumihiko Miura, Kohji Okamoto, Tsann-Long Hwang, Wayne Shih-Wei Huang, Chen-Guo Ker, Miin-Fu Chen, Ho-Seong Han, Yoo-Seok Yoon, In-Seok Choi, Dong-Sup Yoon, Yoshinori Noguchi, Satoru Shikata, Tomohiko Ukai, Ryota Higuchi, Toshifumi Gabata, Yasuhisa Mori, Yukio Iwashita, Taizo Hibi, Palepu Jagannath, Eduard Jonas, Kui-Hin Liau, Christos Dervenis, Dirk Joan Gouma, Daniel Cherqui, Giulio Belli, O James Garden, Mariano Eduardo Giménez, Eduardo de Santibañes, Kenji Suzuki, Akiko Umezawa, Avinash Nivritti Supe, Henry A Pitt, Harjit Singh, Angus C W Chan, Wan Yee Lau, Anthony Yuen Bun Teoh, Goro Honda, Atsushi Sugioka, Koji Asai, Harumi Gomi, Takao Itoi, Seiki Kiriyama, Masahiro Yoshida, Toshihiko Mayumi, Naoki Matsumura, Hiromi Tokumura, Seigo Kitano, Koichi Hirata, Kazuo Inui, Yoshinobu Sumiyama, Masakazu Yamamoto
TG13 Tokyo guidelines for acute cholangitis and cholecystitis were globally disseminated and various clinical researches about the management of acute cholecystitis were reported by lots of researchers and clinicians from all over the world. The 1(st) edition of Tokyo Guidelines 2007 (TG07) was revised in 2013. According to that revision, the TG13 diagnostic criteria of acute cholecystitis provided better specificity and higher diagnostic accuracy. Thorough our literature search about diagnostic criteria for acute cholecystitis, new and strong evidence that had been released from 2013 to 2017 was not found with serious and important issues about using TG13 diagnostic criteria of acute cholecystitis...
October 15, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29020907/atopic-dermatitis-the-new-frontier
#9
REVIEW
Victoria R Harris, Alan J Cooper
Atopic dermatitis (AD) is the most common inflammatory skin condition in adults and children. AD is a chronic disease that has a considerable negative impact on the quality of life of patients and their families. Most cases of AD may be effectively treated with topical therapies that are directed at decreasing cutaneous inflammation and alleviating pruritus. These therapies include emollients, antihistamines, topical corticosteroids, topical calcineurin inhibitors and antimicrobial and antiseptic measures; more refractory cases may require additional oral immunosuppression (eg, cyclosporine, azathioprine, methotrexate and mycophenolate)...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29019460/auditory-hallucinations-as-translational-psychiatry-evidence-from-magnetic-resonance-imaging
#10
Kenneth Hugdahl
In this invited review article I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination, i.e. "hearing a voice", is defined as a sensory experience in the absence of a corresponding external sensory source that could explain the phenomenological experience. I suggest a general frame or scheme for the study of auditory verbal hallucinations which is called Levels of Explanation (LoE)...
October 11, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29019352/hot-news-gene-therapy-with-crispr-cas9-coming-to-age-for-hiv-cure
#11
Vicente Soriano
The huge success of current antiretroviral therapy is mediated by a triple effect: (i) Halting progression to AIDS in infected persons; (ii) reducing the risk of transmission to contacts (treatment as prevention); and (iii) minimizing the risk of HIV acquisition treating uninfected persons at risk (pre-exposure prophylaxis). However, UNAIDS has estimated that only 70% of infected people globally are diagnosed, only 53% are treated, and overall 44% have undetectable viral load, which is the necessary request for ensuring any antiretroviral benefit...
October 11, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28987198/banking-brain-tissue-for-research
#12
Natasja Klioueva, Jasper Bovenberg, Inge Huitinga
Well-characterized human brain tissue is crucial for scientific breakthroughs in research of the human brain and brain diseases. However, the collection, characterization, management, and accessibility of brain human tissue are rather complex. Well-characterized human brain tissue is often provided from private, sometimes small, brain tissue collections by (neuro)pathologic experts. However, to meet the increasing demand for human brain tissue from the scientific community, many professional brain-banking activities aiming at both neurologic and psychiatric diseases as well as healthy controls are currently being initiated worldwide...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28981971/team-science-and-the-physician-scientist-in-the-age-of-grand-health-challenges
#13
REVIEW
Clifford J Steer, Peter R Jackson, Hortencia Hornbeak, Catherine K McKay, P Sriramarao, Michael P Murtaugh
Despite remarkable advances in medical research, clinicians face daunting challenges from new diseases, variations in patient responses to interventions, and increasing numbers of people with chronic health problems. The gap between biomedical research and unmet clinical needs can be addressed by highly talented interdisciplinary investigators focused on translational bench-to-bedside medicine. The training of talented physician-scientists comfortable with forming and participating in multidisciplinary teams that address complex health problems is a top national priority...
September 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28980506/a-descriptive-statistical-analysis-of-volume-visibility-and-attitudes-regarding-nursing-and-care-robots-in-social-media
#14
Martin Salzmann-Erikson, Henrik Eriksson
BACKGROUND: Technology in the healthcare sector is undergoing rapid development. One of the most prominent areas of healthcare in which robots are implemented is nursing homes. However, nursing and technology are often considered as being contradictory, an attitude originating in the view of "the natural" versus "the artificial". Social media mirror this view, including in attitudes and societal debates regarding nursing and care robots. However, little is known about this topic in previous research...
October 5, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28978213/evaluating-new-treatment-options
#15
Steven D Nathan
Idiopathic pulmonary fibrosis (IPF) is the most prevalent type of idiopathic interstitial pneumonia, accounting for at least half of all diagnosed cases. Because it lacks a cure, the goal of treatment for IPF is to stabilize or reduce the rate of disease progression. Nonpharmacologic treatment options for IPF consist of long-term oxygen treatment, lung transplantation, and pulmonary rehabilitation. In the past, pharmacologic therapies for IPF included anticoagulants and anti-inflammatory or immunosuppressive agents...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28974843/characteristics-and-treatment-of-breakthrought-pain-btcp-in-palliative-care
#16
Samir Husic, Semir Imamovic, Srecko Matic, Aziz Sukalo
INTRODUCTION: This research was to follow characteristics of breakthrough pain caused by cancer (BTcP) and other most common sympthoms (ESAS) at patients in advanced stage of cancer disease in palliative care. PATIENTS AND METHODS: Prospective study included 433 patients which were treated in Palliative Care Centre in UKC Tuzla, Bosnia and Herzegovina. Group 1 was consisted of 353 patients whose basal cancer pain of intensity 4-7 NRS was treated weak opiates (basal analgetic- fixed combination of tramadol/paracetamol (37...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28972960/strategies-to-enhance-paracrine-potency-of-transplanted-mesenchymal-stem-cells-in-intractable-neonatal-disorders
#17
REVIEW
Won Soon Park, So Yoon Ahn, Se In Sung, Jee-Yin Ahn, Yun Sil Chang
Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment and direct differentiation of transplanted MSCs, and the 'hit and run' therapeutic effects of these MSCs suggest that their pleiotropic protection might be attributable to paracrine activity via the secretion of various biologic factors rather than to regenerative activity...
October 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28969578/regenerative-medicine-applications-in-wound-care
#18
Mohammad Ali Nilforoushzadeh, Mahsa Mollapour Sisakht, Alexander Marcus Seifalian, Mohammad Amir Amirkhani, Hamid Reza Banafsheh, Javad Verdi, Farzaneh Sharifzad, Ehsan Taghiabadi
BACKGROUND: During the last two decades, a number of studies have been published on different aspects of regenerative medicine in the field of dermatology. OBJECTIVE: The following article aims at integrating all available information about regenerative dermatology, from the past to the present. In addition, we focused on most well-known application of regenerative medicine in dermatology field, wound healing, especially for burns and non-healing wounds based on available skin replacement in market...
September 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28969356/a-transdiagnostic-review-of-negative-symptom-phenomenology-and-etiology
#19
Gregory P Strauss, Alex S Cohen
In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology evaluated for schizophrenia. However, negative symptoms are not pathognomonic-they are also part of the diagnostic criteria for other schizophrenia-spectrum disorders, disorders that sometimes have comorbid psychosis, diagnoses not in the schizophrenia-spectrum, and the general "nonclinical" population. Although etiological models of negative symptoms have been developed for chronic schizophrenia, there has been little attention given to whether these models have transdiagnostic applicability...
July 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28963662/a-study-on-removing-nitrogen-from-paddy-field-rainfall-runoff-by-an-ecological-ditch-zeolite-barrier-system
#20
Xiaoling Wang, Jiansheng Li, Songmin Li, Xiaotong Zheng
Ecological ditches and zeolite have been widely applied in the removal of farmland nonpoint source pollution separately; little research has been done on the effects of combining the two methods. Specifically, few studies have focused on the in situ regeneration of zeolite. A 2-year field experiment using an ecological ditch-zeolite barrier system was conducted in a paddy field of summer rice-winter wheat rotation in the Taihu Lake area. The system consisted of two zeolite barriers positioned at one third and two thirds of the length of the ditch...
September 30, 2017: Environmental Science and Pollution Research International
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