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https://www.readbyqxmd.com/read/28822173/-breakthrough-in-key-science-and-technologies-in-dendrobium-catenatum-industry
#1
Ji-Ping Si, Qi Wang, Zhong-Jian Liu, Jing-Jing Liu, Yi-Bo Luo
In view of the significant difficulties of propagation, planting and simple product in Dendrobium catenatum(D. officinale)industry development, a series of research were carried out. Genome study showed that D. catenatum is a specie of diploid with 38 chromosomes and 28 910 protein-coding genes. It was identified that specific genes accumulated in different organs at the transcriptome level. We got an insight into the gene regulation mechanism of the loss of the endospermous seed, the wide ecological adaptability and the synthesis of polysaccharides, which provided a theoretical basis for genetic engineering breeding and development and utilization of active pharmaceutical ingredients...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28814541/assessing-the-fragile-x-syndrome-newborn-screening-landscape
#2
Catharine Riley, Anne Wheeler
BACKGROUND: Fragile X syndrome (FXS) is the most common known inherited form of intellectual disability. Early identification is an important step in linking FXS individuals with appropriate and timely medical and social services. Newborn screening (NBS) is 1 approach that has been used for other conditions to facilitate early identification. METHODS: A literature review was conducted to identify issues, barriers, challenges, and approaches to addressing challenges related to NBS for FXS...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28803001/continuation-of-comprehensive-quality-control-of-the-itg-68-ge-68-ga-generator-and-production-of-68-ga-dotatoc-and-68-ga-psma-hbed-cc-for-clinical-research-studies
#3
Alejandro Amor-Coarasa, James M Kelly, Monika Gruca, Anastasia Nikolopoulou, Shankar Vallabhajosula, John W Babich
Performance of a second itG (68)Ge/(68)Ga generator system and production of (68)Ga-DOTATOC and (68)Ga-PSMA-HBED-CC were tested over one year as an accompaniment to a previously published study (J Nucl Med. 2016;57:1402-1405). METHODS: Performance of a 1951MBq (68)Ge/(68)Ga generator was characterized and the eluate used for preparation of (68)Ga-DOTATOC and (68)Ga-PSMA-HBED-CC. Weekly elution profiles of (68)Ga elution yield and (68)Ge breakthrough were determined. RESULTS: (68)Ga elution yields averaged 82% (61...
July 14, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28802707/boosting-innate-immunity-to-sustainably-control-diseases-in-crops
#4
REVIEW
Valerie Nicaise
Viruses cause epidemics in all major crops, threatening global food security. The development of efficient and durable resistance able to withstand viral attacks represents a major challenge for agronomy, and relies greatly on the understanding of the molecular dialogue between viral pathogens and their hosts. Research over the last decades provided substantial advances in the field of plant-virus interactions. Remarkably, the advent of studies of plant innate immunity has recently offered new strategies exploitable in the field...
August 10, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28800380/advances-in-risk-analysis-with-big-data
#5
Tsan-Ming Choi, James H Lambert
With cloud computing, Internet-of-things, wireless sensors, social media, fast storage and retrieval, etc., organizations and enterprises have access to unprecedented amounts and varieties of data. Current risk analysis methodology and applications are experiencing related advances and breakthroughs. For example, highway operations data are readily available, and making use of them reduces risks of traffic crashes and travel delays. Massive data of financial and enterprise systems support decision making under risk by individuals, industries, regulators, etc...
August 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28794046/proteomic-and-functional-analyses-of-the-virion-transmembrane-proteome-of-cyprinid-herpesvirus-3
#6
Catherine Vancsok, Ma Michelle D Peñaranda, V Stalin Raj, Baptiste Leroy, Joanna Jazowiecka-Rakus, Maxime Boutier, Yuan Gao, Gavin S Wilkie, Nicolás M Suárez, Ruddy Wattiez, Laurent Gillet, Andrew J Davison, Alain F C Vanderplasschen
Virion transmembrane proteins (VTPs) mediate key functions in the herpesvirus infectious cycle. Cyprinid herpesvirus 3 (CyHV-3) is the archetype of fish alloherpesviruses. The present study was devoted to CyHV-3 VTPs. Using mass spectrometry approaches, we identified 16 VTPs of the CyHV-3 FL strain. Mutagenesis experiments demonstrated that eight of these proteins are essential for viral growth in vitro (ORF32, ORF59, ORF81, ORF83, ORF99, ORF106, ORF115, and ORF131), and eight are non-essential (ORF25, ORF64, ORF65, ORF108, ORF132, ORF136, ORF148, and ORF149)...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28783208/possible-case-of-halogen-bond-driven-self-disproportionation-of-enantiomers-sde-via-achiral-chromatography
#7
Vadim Anatolievich Soloshonok, Shumpei Terada, Motohiro Hirai, Ayaka Honzawa, Osamu Kitagawa, Angelika Kamizela, Alicja Wzorek
The major breakthrough reported in this work is the discovery of likely halogen bond-driven self-disproportionation of enantiomers (SDE). Taking into account that the halogen bonding interactions can be rationally designed and can match, or even exceed, the strength of the more familiar hydrogen bond, this discovery clearly opens an unexpected new direction of research in the areas of molecular chirality and the SDE phenomenon.
August 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28783106/melanin-based-contrast-agents-for-biomedical-optoacoustic-imaging-and-theranostic-applications
#8
REVIEW
Dario Livio Longo, Rachele Stefania, Silvio Aime, Alexander Oraevsky
Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic approach to molecular imaging, and delivers high-resolution images in the depth of tissue. Resolution of the optoacoustic imaging is scalable, so that biomedical systems from cellular organelles to large organs can be visualized and, more importantly, characterized based on their optical absorption coefficient, which is proportional to the concentration of absorbing chromophores...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28780221/making-breakthroughs-in-the-turbulent-decade-china-s-space-technology-during-the-cultural-revolution
#9
Chengzhi Li, Dehui Zhang, Danian Hu
This article discusses why Chinese space programs were able to develop to the extent they did during the turbulent decade of the Cultural Revolution (1966-1976). It first introduces briefly what China had accomplished in rocket and missile technology before the Cultural Revolution, including the establishment of a system for research and manufacturing, breakthroughs in rocket technology, and programs for future development. It then analyzes the harmful impacts of the Cultural Revolution on Chinese space programs by examining activities of contemporary mass factions in the Seventh Ministry of Machinery Industry...
August 2, 2017: Endeavour
https://www.readbyqxmd.com/read/28776411/the-importance-for-immunoregulation-for-long-term-cancer-control
#10
Alberto Fusi, Angus Dalgleish
Immune checkpoint blockades have recently emerged as a breakthrough treatment for solid tumors showing high response rates and long durability. In melanoma, the combination of ipilimumab with nivolumab showed high efficacy. However, still half the patients do not respond to this treatment. In order to increase the therapeutic ratio in melanoma and other cancers, different approaches are under evaluation. Three relevant questions are at the moment driving the research community: how to maximize benefit while minimizing toxicity; how to better identify patients who are more likely to benefit from immunotherapy; how to convert nonresponders into responders...
August 4, 2017: Future Oncology
https://www.readbyqxmd.com/read/28774408/hepatitis-b-virus-infection-and-the-immune-response-the-big-questions
#11
REVIEW
Lauke L Boeijen, Ruben C Hoogeveen, Andre Boonstra, Georg M Lauer
Clinical events and the host immune response during hepatitis B virus (HBV) infection are intricately linked. Despite decades of research, important questions concerning the immunopathogenesis of chronic HBV infection remain unanswered. For example, it is unclear which immune parameters facilitate persistence, and if HBV can be completely cleared from the human liver. Recent technological breakthroughs now allow researchers to address these seemingly basic, but essential questions surrounding HBV immunity. It will be important to better define the molecular underpinnings of immune cell function and dysfunction during chronic disease and in controlled infection, with particular focus on the liver, as little information is available on the intrahepatic compartment...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28772362/a-comprehensive-review-of-the-study-and-development-of-microcapsule-based-self-resilience-systems-for-concrete-structures-at-shenzhen-university
#12
REVIEW
Ning-Xu Han, Feng Xing
A review of the research activities and achievements at Shenzhen University is conducted in this paper concerning the creation and further development of novel microcapsule based self-resilience systems for their application in concrete structures. After a brief description of pioneering works in the field starting about 10 years ago, the principles raised in the relevant research are examined, where fundamental terms related to the concept of resilience are discussed. Several breakthrough points are highlighted concerning the three adopted comprehensive self-resilience systems, namely physical, chemical and microbial systems...
December 22, 2016: Materials
https://www.readbyqxmd.com/read/28769878/ecological-energetic-perspectives-on-responses-of-nitrogen-transforming-chemolithoautotrophic-microbiota-to-changes-in-the-marine-environment
#13
REVIEW
Hongyue Dang, Chen-Tung A Chen
Transformation and mobilization of bioessential elements in the biosphere, lithosphere, atmosphere, and hydrosphere constitute the Earth's biogeochemical cycles, which are driven mainly by microorganisms through their energy and material metabolic processes. Without microbial energy harvesting from sources of light and inorganic chemical bonds for autotrophic fixation of inorganic carbon, there would not be sustainable ecosystems in the vast ocean. Although ecological energetics (eco-energetics) has been emphasized as a core aspect of ecosystem analyses and microorganisms largely control the flow of matter and energy in marine ecosystems, marine microbial communities are rarely studied from the eco-energetic perspective...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28769807/hurdles-in-basic-science-translation
#14
Christina J Perry, Andrew J Lawrence
In the past century there have been incredible advances in the field of medical research, but what hinders translation of this knowledge into effective treatment for human disease? There is an increasing focus on the failure of many research breakthroughs to be translated through the clinical trial process and into medical practice. In this mini review, we will consider some of the reasons that findings in basic medical research fail to become translated through clinical trials and into basic medical practices...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28766845/neural-stem-cell-therapy-aiming-at-better-functional-recovery-after-spinal-cord-injury
#15
REVIEW
Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Kinichi Nakashima
Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits...
August 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28764564/neonatal-renal-cystic-diseases
#16
Anshika Khare, Vinod Krishnappa, Deepak Kumar, Rupesh Raina
PURPOSE: Neonatal renal cystic diseases have a great impact on the morbidity and mortality of the affected neonates and infants. A good insight into the pathophysiology, diagnosis and treatment options of various neonatal renal cystic diseases aid in early diagnosis and intervention, thereby preventing complications. METHODS: PubMed search was done for articles on "neonatal renal cystic diseases" and relevant publications including reviews were considered for our article...
August 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28759449/adsorption-of-hg-ii-and-pb-ii-ions-by-nanoscale-zero-valent-iron-supported-on-ostrich-bone-ash-in-a-fixed-bed-column-system
#17
Mohammad Javad Amiri, Jahangir Abedi-Koupai, Saeid Eslamian
In this research, ostrich bone ash (OBA) was modified with nanoscale zerovalent iron (nZVI) particles and applied as a novel composite adsorbent (OBA/nZVI) for dynamic adsorption/reduction of Hg(II) and Pb(II) ions in a fixed-bed column system. Entrapment of nZVI in OBA beads barricades the particles from oxidation and aggregation. The dynamic behavior of metal ions removal by OBA/nZVI was assessed as a function of inlet flow rates, bed height, initial pollutants concentration and pH. The synthesized OBA/nZVI composite was characterized by several physicochemical techniques...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28756087/a-glimpse-of-membrane-transport-through-structures-advances-in-the-structural-biology-of-the-glut-glucose-transporters
#18
REVIEW
Nieng Yan
The cellular uptake of glucose is an essential physiological process, and movement of glucose across biological membranes requires specialized transporters. The major facilitator superfamily glucose transporters GLUTs, encoded by the SLC2A genes, have been a paradigm for functional, mechanistic, and structural understanding of solute transport in the past century. This review starts with a glimpse into the structural biology of membrane proteins and particularly membrane transport proteins, enumerating the landmark structures in the past 25years...
July 26, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28752194/from-engineering-to-editing-the-rat-genome
#19
Stephen Meek, Tomoji Mashimo, Tom Burdon
Since its domestication over 100 years ago, the laboratory rat has been the preferred experimental animal in many areas of biomedical research (Lindsey and Baker The laboratory rat. Academic, New York, pp 1-52, 2006). Its physiology, size, genetics, reproductive cycle, cognitive and behavioural characteristics have made it a particularly useful animal model for studying many human disorders and diseases. Indeed, through selective breeding programmes numerous strains have been derived that are now the mainstay of research on hypertension, obesity and neurobiology (Okamoto and Aoki Jpn Circ J 27:282-293, 1963; Zucker and Zucker J Hered 52(6):275-278, 1961)...
July 27, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28741130/epigenetic-involvement-in-etiopathogenesis-and-implications-in-treatment-of-systemic-lupus-erythematous
#20
REVIEW
Arron Munggela Foma, Saeed Aslani, Jafar Karami, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND: Recent researches in the field of genetics have extended our knowledge through the discovery of genetic factors associated with autoimmune diseases (AID). Genetics by itself, however, cannot elucidate all the uncertainties encountered in the etiopathology of AID. On the other hand, incomplete harmony in the prevalence of AID in identical twins suggests that non-genetic factors may play an important role in determining the disease susceptibility. Besides, epigenetics, which is defined by changes in gene expression without a corresponding change in the DNA sequences, has come in to provide new awareness in the disease etiopathology by bridging the genetic and epigenetic factors...
July 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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