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https://www.readbyqxmd.com/read/28635382/white-cell-and-platelet-content-affects-the-release-of-bioactive-factors-in-different-blood-derived-scaffolds
#1
S Cabaro, V D'Esposito, R Gasparro, F Borriello, F Granata, G Mosca, F Passaretti, J C Sammartino, F Riccitiello, F Beguinot, P Formisano, G Sammartino
Platelet-derived factors are biomaterials that might accelerate healing process in oral, maxillofacial, and several other applications. Release of specific factors by platelet concentrates is critical to achieving a successful outcome. Here, we have shown that platelet-rich fibrin (PRF) clots were beneficial sources of leukocytes, which may directly affect the release of chemokines and growth factors. When compared with the standard leukocyte-PRF (L-PRF), the experimental low-force modified procedure [defined as advanced-PRF (A-PRF)] entrapped the same content of viable leukocytes, released a similar amount of inflammatory cytokines, but secreted 3-, 1...
June 21, 2017: Platelets
https://www.readbyqxmd.com/read/28632935/impact-of-preoperative-calculation-of-nephron-volume-loss-on-future-of-partial-nephrectomy-techniques-planning-a-strategic-roadmap-for-improving-functional-preservation-and-securing-oncological-safety
#2
Koon Ho Rha, Ali Abdel Raheem, Sung Yul Park, Kwang Hyun Kim, Hyung Joon Kim, Kyo Chul Koo, Young Deuk Choi, Byung Ha Jung, Sang Kon Lee, Won Ki Lee, Jayram Krishnan, Tae Young Shin, Jin-Seon Cho
OBJECTIVES: To assess the correlation of resected and ischaemised volume (RAIV), which is preoperatively calculated volume of nephron loss (VNL), with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi-institutional dataset. SUBJECTS AND METHODS: We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robotic PN (n = 263) performed were retrospectively gathered...
June 20, 2017: BJU International
https://www.readbyqxmd.com/read/28626095/-role-of-the-autophagy-in-the-treatment-of-neuropathic-pain-with-pulsed-radiofrequency
#3
Lin Yang, Liang Guo, Junmei Xu, Yaping Wang, Dingquan Zou, Xinghua Jiang
To detect the effect of pulse radiofrequency (PRF) treatment on the neuropathic pain established by L5-spinal nerve ligation (SNL) on rats, and to investigate if PRF treatment would affect the expression of autophagy related protein LC3 and autophagy related receptor P62 at the dorsal horn.
 Methods: A total of 36 male Sprague-Dawley rats were randomly divided into 3 groups: a Sham group, a SNL group, and a SNL+PRF group. The 50% paw withdrawal mechanical threshold (PWMT) was detected at 1 day before and 1, 3, 7, 14 and 28 days post-operation by using Von-Frey filaments...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28622796/cardiac-magnetic-resonance-indices-reflecting-pulmonary-regurgitation-burden-after-tetralogy-of-fallot-repair
#4
A A Sakrana, S A Al-Zubaidi, M M Nasr, E M Helmy, S S Al Ghamdi, M E Tahlawi
AIM: To investigate cardiac magnetic resonance (CMR)-derived parameters to determine a convenient index reflecting the degree of pulmonary regurgitation (PR) after Tetralogy of Fallot (TOF) repair. MATERIALS AND METHODS: Sixty-three patients (age at CMR study, 23.6 [10.2-34.7] years, 55.6% male) underwent CMR after TOF repair. PR was quantified using ventricular stroke volume difference and phase-contrast mapping of the main pulmonary artery flow. In both approaches, the PRV index (PRVI) and the PR fraction (PRF) were calculated and correlated to the right ventricle end-diastolic volume index (RVEDVI) and the right ventricle end-systolic volume index (RVESVI)...
June 13, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28622320/a-novel-graft-option-after-pterygium-excision-platelet-rich-fibrin-for-conjunctivoplasty
#5
H B Cakmak, G Dereli Can, M E Can, N Cagil
PurposeTo compare the surgical results, complications, and recurrence rates of primary pterygium excision with conjunctival autografts (CA) vs platelet-rich fibrin (PRF) grafts.Patients and methodsA total of 35 eyes of 35 patients with primary pterygium were included in the study. The patients underwent excision of pterygium followed by closure of the bare sclera by CA (group 1, n=20) vs PRF grafts (group 2, n=15). The PRF was generated from the patients' own whole-blood sample by centrifugation and pressing...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28616662/perifosine-enhances-bevacizumab-induced-apoptosis-and-therapeutic-efficacy-by-targeting-pi3k-akt-pathway-in-a-glioblastoma-heterotopic-model
#6
Sara Ramezani, Nasim Vousooghi, Fatemeh Ramezani Kapourchali, Mohammad Taghi Joghataei
Bevacizumab (BVZ) as an antiangiogenesis therapy leads to a transient therapeutic efficacy in high-grade glioma. However, the proapoptotic potential of BVZ has not been well elucidated, yet. There is also a tumor resistance to BVZ that is linked to post-treatment metalloproteinases and AKT activities. Herein, the association between therapeutic efficacy and putative proapoptotic activity of low-dose BVZ either alone or in combination with a specific inhibitor of AKT called perifosine (PRF), in a glioma model was investigated...
June 14, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28596670/growth-factor-variation-in-two-types-of-autologous-platelet-biomaterials-prp-versus-prf
#7
Satyam Arora, Urvershi Kotwal, Mitu Dogra, Veena Doda
Autologous platelet biomaterials represent a key source of cytokines and growth factors extensively used for clinical and surgical applications involving tissue regeneration; wound healing and tissue repair. In this communication we discuss the growth factors released by activated platelet rich plasma (PRP) and platelet rich fibrin (PRF) releasate. Our study highlights that significantly higher growth factors (TGF-ß1) are released by activated PRP as compared to releasate of PRF. The various growth factors released by both platelet products are significantly higher than the baseline concentration in the whole blood and have different bio-mechanism hence should be individualized as per the clinical indication...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28596050/histological-evaluation-of-effectiveness-of-platelet-rich-fibrin-on-healing-of-sinus-membrane-perforations-a-preclinical-animal-study
#8
Ceyhun Aricioglu, Dogan Dolanmaz, Alparslan Esen, Kubilay Isik, Mustafa Cihat Avunduk
The aim of this study was to evaluate the effectiveness of platelet-rich fibrin (PRF) in repairing of Schneiderian membrane perforations in rabbit maxillary sinus. A total of 42 female New Zealand rabbits were randomly divided into two groups. Symmetrical bony defects were created 1 cm in diameter and the sinus membranes were exposed. The Schneiderian membranes were elevated in both sinuses and each membrane was perforated with a 1 cm incision. No treatment was applied to the right perforations in both groups...
May 15, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28593072/recovery-and-return-to-work-after-a-pelvic-fracture
#9
Antonios N Papasotiriou, Nikolaos Prevezas, Konstantinos Krikonis, Evangelos C Alexopoulos
BACKGROUND: Pelvic ring fractures (PRFs) may influence the daily activities and quality of life of the injured. The aim of this retrospective study was to explore the functional outcomes and factors related to return to work (RTW) after PRF. METHODS: During the years 2003-2012, 282 injured individuals aged 20-55 years on the date of the accident, were hospitalized and treated for PRFs in a large tertiary hospital in Athens, Greece. One hundred and three patients were traced and contacted; 77 who were on paid employment prior to the accident gave their informed consent to participate in the survey, which was conducted in early 2015 through telephone interviews...
June 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28590091/an-update-on-the-protocols-and-biologic-actions-of-platelet-rich-fibrin-in-dentistry
#10
Rucha Shah, Triveni M G, Raison Thomas, Dhoom Singh Mehta
Platelet rich fibrin (PRF) is a surgical biologic additive that is prepared by manipulation of autologous blood. It has now evolved to become one of the most widely used platelet concentrate in dentistry. It has almost replaced Platelet rich plasma (PRP) for usage owing to its advantages such as being 100% autogenous, easy technique, time and cost effectiveness, superior & prolonged growth factor release. It finds varied applications in dentistry including management of gingival recession, for guided bone regeneration in periodontal, peri-implant and endodontic bone defects...
June 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28587096/the-effect-of-platelet-rich-fibrin-calcium-sulfate-hemihydrate-platelet-rich-plasma-and-resorbable-collagen-on-soft-tissue-closure-of-extraction-sites
#11
Lisa M Yerke, Amal Jamjoom, Talal M Zahid, Robert E Cohen
Rapid and complete soft tissue healing after tooth extraction minimizes surgical complications and facilitates subsequent implant placement. We used four treatment methods and assessed changes in soft tissue socket closure following tooth extraction in humans. The effects of platelet-rich fibrin-calcium sulfate hemihydrate (PRF-CSH), platelet-rich plasma-calcium sulfate hemihydrate (PRP-CSH), a resorbable collagen dressing (RCD), and no grafting material were compared in a randomized, controlled pilot study with a blinded parallel design (N = 23)...
May 25, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28586376/oncologic-and-surgical-outcomes-in-colorectal-cancer-patients-with-liver-cirrhosis-a-propensity-matched-study
#12
Eon Chul Han, Seung-Bum Ryoo, Ji Won Park, Jin Wook Yi, Heung-Kwon Oh, Eun Kyung Choe, Heon-Kyun Ha, Byung Kwan Park, Sang Hui Moon, Seung-Yong Jeong, Kyu Joo Park
The management of colorectal cancer in patients with liver cirrhosis requires a thorough understanding of both diseases. This study evaluated the effect of liver cirrhosis on oncologic and surgical outcomes and prognostic factors in colorectal cancer patients. Fifty-five consecutive colorectal cancer patients with liver cirrhosis underwent colorectal resection (LC group). Using a prospectively maintained database, these patients were matched 1:4 using propensity scoring with R programming language, package "MatchIt" and "optmatch" by sex, age, cancer location, and tumor stage with 220 patients without liver cirrhosis (non-LC group), resulting in 275 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28580706/mr-techniques-for-guiding-high-intensity-focused-ultrasound-hifu-treatments
#13
REVIEW
Kagayaki Kuroda
To make full use of the ability of magnetic resonance (MR) to guide high-intensity focused ultrasound (HIFU) treatment, effort has been made to improve techniques for thermometry, motion tracking, and sound beam visualization. For monitoring rapid temperature elevation with proton resonance frequency (PRF) shift, data acquisition and processing can be accelerated with parallel imaging and/or sparse sampling in conjunction with appropriate signal processing methods. Thermometry should be robust against tissue motion, motion-induced magnetic field variation, and susceptibility change...
June 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28575334/characterization-of-peripheral-and-central-sensitization-after-dorsal-root-ganglion-intervention-in-patients-with-unilateral-lumbosacral-radicular-pain-a-prospective-pilot-study
#14
V Mehta, S Snidvongs, B Ghai, R Langford, T Wodehouse
Background.: Quantitative sensory testing (QST) has been used to predict the outcome of epidural steroid injections in lumbosacral radicular pain and has the potential to be an important tool in the selection of appropriate treatment (such as epidural steroid injections vs surgery) for patients with chronic radicular pain. In addition, QST assists in identification of the pain pathways of peripheral and central sensitization in selected groups of patients. Methods.: Twenty-three patients were given dorsal root ganglion (DRG) infiltration with local anaesthesia and steroid ('DRG block'), and those who demonstrated at least 50% pain relief were offered pulsed radiofrequency (PRF) to the DRG...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28571302/successful-surgical-outcome-for-an-endodontic-failure-using-biodentine-tm-as-retrograde-restoration-in-conjunction-with-platelet-rich-fibrin-prf-for-progressive-healing
#15
Ajinkya Mansing Pawar, Suraj M Pawar, Bhagyashree Thakur, Sharad Kokate
No abstract text is available yet for this article.
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28571284/evaluation-of-periapical-healing-of-apicomarginal-defect-in-mandibular-first-molar-treated-with-platelet-rich-fibrin-a-case-report
#16
Jitesh Wadhwa, Alpa Gupta, Suruchi Hans
The presence of an apicomarginal defect is one of the reasons for the failure of endodontic treatment. The best treatment option to treat an apicomarginal defect is to perform endodontic surgery using Guided Tissue Regeneration (GTR) membranes. The present case report evaluated the healing of periapical lesion along with apicomarginal defect using Platelet Rich Fibrin (PRF) as membrane in periapical surgery of mandibular first molar. Recall examination was performed at 3 and 18 months post surgery. A satisfactory periapical healing was evident using PRF in apicomarginal defect of mandibular first molar...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28571267/effect-of-autologous-platelet-rich-fibrin-in-human-mandibular-molar-grade-ii-furcation-defects-a-randomized-clinical-trial
#17
Syed Asimuddin, Rekha Rani Koduganti, Veerendra Nath Reddy Panthula, Surya Prasanna Jammula, Rajashree Dasari, Himabindu Gireddy
INTRODUCTION: The Furcation of multirooted teeth is difficult region to gain access for treatment due to their complex anatomy. Modifications have been made in the periodontal instrument armamentarium to facilitate treatment of furcations. Moreover, many new materials have been introduced to attempt regeneration in the furcation defects. AIM: This study evaluated the role of Platelet Rich Fibrin (PRF) in comparison with allograft and Guided Tissue Regeneration (GTR) in the treatment of Grade II mandibular molar furcations...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28567705/diagnostic-value-of-doppler-echocardiography-for-identifying-hemodynamic-significant-pulmonary-valve-regurgitation-in-tetralogy-of-fallot-comparison-with-cardiac-mri
#18
Niek E G Beurskens, Thomas M Gorter, Petronella G Pieper, Elke S Hoendermis, Beatrijs Bartelds, Tjark Ebels, Rolf M F Berger, Tineke P Willems, Joost P van Melle
Quantification of pulmonary regurgitation (PR) is essential in the management of patients with repaired tetralogy of Fallot (TOF). We sought to evaluate the accuracy of first-line Doppler echocardiography in comparison with cardiac magnetic resonance imaging (MRI) to identify hemodynamic significant PR. Paired cardiac MRI and echocardiographic studies (n = 97) in patients with repaired TOF were retrospectively analyzed. Pressure half time (PHT) and pulmonary regurgitation index (PRi) were measured using continuous wave Doppler...
May 31, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28565782/hybrid-composites-of-mesenchymal-stem-cell-sheets-hydroxyapatite-and-platelet-rich-fibrin-granules-for-bone-regeneration-in-a-rabbit-calvarial-critical-size-defect-model
#19
Xi Wang, Guanghui Li, Jia Guo, Lei Yang, Yiming Liu, Qiang Sun, Rui Li, Weiwei Yu
The reconstruction of large bone defects remains a major clinical challenge, and tissue engineering is a promising technique for resolving this problem. Many attempts have been made to optimize bone tissue engineering protocols. The aim of the present study was to develop a process incorporating mesenchymal stem cell (MSC) sheets with nanoscale hydroxyapatite (nano-HA) and autologous platelet-rich fibrin (PRF) granules for enhanced bone formation within a critical-sized rabbit cranial defect. MSC sheets and PRF were prepared prior to in vivo experiments...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560233/evolution-current-status-and-advances-in-application-of-platelet-concentrate-in-periodontics-and-implantology
#20
REVIEW
Amit Arvind Agrawal
Platelet concentrates (PC) [platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] are frequently used for surgical procedures in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery and sports medicine. The objective of all these technologies is to extract all the elements from a blood sample that could be used to improve healing and promote tissue regeneration. Although leukocyte rich and leukocyte poor PRP's have their own place in literature, the importance of non-platelet components in a platelet concentrate remains a mystery...
May 16, 2017: World Journal of Clinical Cases
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