Mingxu Zhao, Mengni Zhou, Pengcheng Lu, Ying Wang, Rong Zeng, Lifang Liu, Shasha Zhu, Lingsuo Kong, Jiqian Zhang
Postoperative pain (POP) is a major clinical challenge. Local anesthetics (LAs), including amide-type LAs, ester-type LAs, and other potential ion-channel blockers, are emerging as drugs for POP management because of their effectiveness and affordability. However, LAs typically exhibit short durations of action and prolonging the duration by increasing their dosage or concentration may increase the risk of motor block or systemic local anesthetic toxicity. In addition, techniques using LAs, such as intrathecal infusion, require professional operation and are prone to catheter displacement, dislodgement, infection, and nerve damage...
April 26, 2024: Acta Biomaterialia