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https://www.readbyqxmd.com/read/29663489/high-glucose-induced-excessive-reactive-oxygen-species-promote-apoptosis-through-mitochondrial-damage-in-rat-cartilage-endplate-cells
#1
Zengxin Jiang, Wei Lu, Qingmin Zeng, Defang Li, Lei Ding, Jingping Wu
PURPOSE: Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells is one of the initiators of IDD. However, the effects of high glucose on CEP cells are still unknown. Therefore, we conducted the present study to evaluate the effects of high glucose on CEP cells and to identify the mechanisms of those effects. METHODS: Rat CEP cells were isolated and cultured in 10% foetal bovine serum (FBS, normal control) or high-glucose medium (10% FBS + 0...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29658365/resveratrol-delivery-by-ultrasound-mediated-nanobubbles-targeting-nucleus-pulposus-cells
#2
Jieliang Shen, Naiqiang Zhuo, Shenxi Xu, Zhaojun Song, Zhenming Hu, Jie Hao, Xiuming Guo
AIM: To improve nucleus pulposus cell-targeted therapy for intervertebral disc degeneration (IDD) by fabricating a novel kind of ultrasound (US)-mediated poly(lactic-co-glycolic acid) nanobubbles (NBs) as a means of targeted drug delivery. MATERIALS & METHODS: The resveratrol (RES)-embedded NBs were synthesized using a double-emulsion method. The active NP cell-targeting biomarker CDH2 antibody (AbCDH2) was further conjugated to the NBs using a carbodiimide method...
April 16, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29652777/meta-analysis-of-the-association-between-fas-ligand-and-trail-genetic-polymorphisms-and-intervertebral-disc-degeneration-susceptibility-in-chinese-han-population
#3
Xin Huang, Weiyue Zhang, Zengwu Shao
STUDY DESIGN: Meta-analysis to collect all the relevant studies to further investigate whether or not the FAS ligand (FASL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) genetic polymorphisms are associated with susceptibility to intervertebral disc degeneration (IDD) in Chinese Han population. OBJECTIVE: To investigate whether or not the FASL and TRAIL genetic polymorphisms are associated with susceptibility to IDD in Chinese Han population...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29650748/exploring-the-prenatal-experience-of-women-with-intellectual-and-developmental-disabilities-in-a-southeastern-ontario-family-health-team
#4
Elaine Xie, Meg Gemmill
OBJECTIVE: To identify psychosocial challenges facing pregnant women with intellectual and developmental disabilities (IDD) using retrospective, routinely collected electronic medical record data. DESIGN: A retrospective qualitative study using narratives and supporting documents found in the electronic medical record of an academic family health team (FHT). SETTING: Academic FHT in southeastern Ontario. PARTICIPANTS: A sample of 10 women with a diagnosis of IDD, rostered to physicians at the academic FHT, who delivered a child between January 2010 and June 2015 (14 pregnancies)...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650747/patient-centred-primary-care-of-adults-with-severe-and-profound-intellectual-and-developmental-disabilities-patient-caregiver-physician-relationship
#5
Katherine Stringer, Amanda L Terry, Bridget L Ryan, Andrea Pike
OBJECTIVE: To explore the process of the development of the patient-physician relationship in adult patients with severe or profound intellectual and developmental disabilities (IDD), from the perspective of the patients' caregivers. DESIGN: Constructivist grounded theory. SETTING: St John's, NL. PARTICIPANTS: Thirteen primary caregivers (5 males, 8 females) of 1 or more adults with severe or profound IDD. METHODS: Data were collected via in-depth, semistructured interviews conducted in person or by telephone...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650746/comprehensive-preventive-care-assessments-for-adults-with-intellectual-and-developmental-disabilities-part-1-how-do-we-know-if-it-is-happening
#6
Glenys Smith, Hélène Ouellette-Kuntz, Michael Green
OBJECTIVE: To determine how best to measure the provision of comprehensive preventive care assessment of adults with intellectual and developmental disabilities (IDD). DESIGN: Cross-sectional study. SETTING: Ontario. PARTICIPANTS: Adults with IDD between 40 and 64 years of age in 2013 and 2014. MAIN OUTCOME MEASURES: Health examination was defined using the Ontario Health Insurance Plan billing data fee code A003 (with diagnostic code 917 or 319) or fee code K131, and the Primary Care Quality Composite Score (PCQS), a measure combining 7 different screening maneuvers (lipid, glucose, breast cancer, cervical cancer, colorectal cancer, eye, and hemoglobin A1c screening), was identified using administrative health data...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650745/circles-of-care-for-people-with-intellectual-and-developmental-disabilities-communication-collaboration-and-coordination
#7
REVIEW
Karen McNeil, Meg Gemmill, Dara Abells, Samantha Sacks, Terry Broda, Catherine R Morris, Cynthia Forster-Gibson
OBJECTIVE: To review health information exchange (HIE) processes that affect the health of people with intellectual and developmental disabilities (IDD) and to suggest practical tips and strategies for communicating, collaborating, and coordinating in the primary care setting. SOURCES OF INFORMATION: The "Primary care of adults with intellectual and developmental disabilities. 2018 Canadian consensus guidelines" literature review and interdisciplinary input...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650744/health-checks-for-adults-with-intellectual-and-developmental-disabilities-in-a-family-practice
#8
REVIEW
Ian Casson, Terry Broda, Janet Durbin, Angela Gonzales, Laurie Green, Elizabeth Grier, Yona Lunsky, Avra Selick, Kyle Sue
OBJECTIVE: To provide tips and tools for primary care practitioners carrying out health checks for adult patients with intellectual and developmental disabilities (IDD) and for implementing a systematic program of health checks in a group or team practice. SOURCES OF INFORMATION: The "Primary Care of Adults with Intellectual and Developmental Disabilities. 2018 Canadian Consensus Guidelines" literature review and interdisciplinary input. Experience in implementing health checks in family practices was obtained through the primary care project of H-CARDD (Health Care Access Research and Developmental Disabilities)...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650743/improving-transition-to-adulthood-for-adolescents-with-intellectual-and-developmental-disabilities-proactive-developmental-and-systems-perspective
#9
REVIEW
Shara Ally, Kerry Boyd, Dara Abells, Khush Amaria, Yani Hamdani, Alvin Loh, Ullanda Niel, Samantha Sacks, Sarah Shea, William F Sullivan, Brian Hennen
OBJECTIVE: To demonstrate how family physicians can contribute to a piece of the journey of improving quality-of-life outcomes for people with intellectual and developmental disabilities (IDD) when they undergo the transition from adolescence to adulthood. SOURCES OF INFORMATION: The "Primary care of adults with intellectual and developmental disabilities. 2018 Canadian consensus guidelines" literature review and interdisciplinary input. MAIN MESSAGE: Family physicians should be proactive in anticipating and supporting the transition of people with IDD from adolescence to adulthood...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650742/supporting-adults-with-intellectual-and-developmental-disabilities-to-participate-in-health-care-decision-making
#10
REVIEW
William F Sullivan, John Heng
OBJECTIVE: To discuss what is new in the revised guideline 3 of the "Primary care of adults with intellectual and developmental disabilities [IDD]. 2018 Canadian consensus guidelines" on decision-making capacity, and how to implement the recommendations. QUALITY OF EVIDENCE: Integrative review based on a literature search, the framework of the United Nations Convention on the Rights of Persons with Disabilities, and the experience of the authors. MAIN MESSAGE: Person-centred health care of adults with IDD should include all possible contributions from the patient in decision making...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650741/help-for-behaviours-that-challenge-in-adults-with-intellectual-and-developmental-disabilities
#11
REVIEW
Laurie Green, Karen McNeil, Marika Korossy, Kerry Boyd, Elizabeth Grier, MacKenzie Ketchell, Alvin Loh, Yona Lunsky, Shirley McMillan, Amanda Sawyer, Anupam Thakur, Elspeth Bradley
OBJECTIVE: To provide primary care physicians with an understanding of the causes of behaviours that challenge (BTC) in adults with intellectual and developmental disabilities (IDD), as presented in the 2018 Canadian consensus guidelines for primary care of adults with IDD; to offer a systematic approach to the assessment and treatment of such behaviours; and to link to tools to support these assessments. SOURCES OF INFORMATION: This review elaborates upon guidelines 26 to 29 in the mental health section of the 2018 Canadian consensus guidelines...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650740/managing-complexity-in-care-of-patients-with-intellectual-and-developmental-disabilities-natural-fit-for-the-family-physician-as-an-expert-generalist
#12
REVIEW
Elizabeth Grier, Dara Abells, Ian Casson, Meg Gemmill, Jessica Ladouceur, Amanda Lepp, Ullanda Niel, Samantha Sacks, Kyle Sue
OBJECTIVE: To delineate the factors inherent in caring for patients with intellectual and developmental disabilities (IDD) that lead to complexity and to provide perspectives and techniques mapped to the phases of the clinical encounter. SOURCES OF INFORMATION: The authors of the physical health section of the 2018 Canadian consensus guidelines on the primary care of adults with IDD consisted of family physicians, all of whom practise comprehensive family medicine with additional clinical experience in care of adults with IDD...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650602/primary-care-of-adults-with-intellectual-and-developmental-disabilities-2018-canadian-consensus-guidelines
#13
William F Sullivan, Heidi Diepstra, John Heng, Shara Ally, Elspeth Bradley, Ian Casson, Brian Hennen, Maureen Kelly, Marika Korossy, Karen McNeil, Dara Abells, Khush Amaria, Kerry Boyd, Meg Gemmill, Elizabeth Grier, Natalie Kennie-Kaulbach, Mackenzie Ketchell, Jessica Ladouceur, Amanda Lepp, Yona Lunsky, Shirley McMillan, Ullanda Niel, Samantha Sacks, Sarah Shea, Katherine Stringer, Kyle Sue, Sandra Witherbee
OBJECTIVE: To update the 2011 Canadian guidelines for primary care of adults with intellectual and developmental disabilities (IDD). METHODS: Family physicians and other health professionals experienced in the care of people with IDD reviewed and synthesized recent empirical, ecosystem, expert, and experiential knowledge. A system was developed to grade the strength of recommendations. RECOMMENDATIONS: Adults with IDD are a heterogeneous group of patients and have health conditions and factors affecting their health that can vary in kind, manifestation, severity, or complexity from those of others in the community...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29649939/participation-patterns-of-preschool-children-with-intellectual-developmental-disabilities
#14
Yafit Gilboa, Reut Fuchs
We aim to examine the pattern of participation of children with intellectual developmental disabilities (IDD) or global developmental delay (GDD) in comparison with typically developing preschoolers. In addition, to identify environmental and personal factors associated with their participation, 20 children with mild to moderate GDD or IDD, and 24 age- and gender-matched controls, aged 3 to 6 years, were assessed using the Assessment of Preschool Children's Participation and the Environmental Restriction Questionnaire...
April 1, 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29649547/early-onset-disc-degeneration-in-sm-j-mice-is-associated-with-ion-transport-systems-and-fibrotic-changes
#15
Ying Zhang, Chi Xiong, Mateusz Kudelko, Yan Li, Cheng Wang, Yuk Lun Wong, Vivian Tam, Muhammad Farooq Rai, James Cheverud, Heather A Lawson, Linda Sandell, Wilson C W Chan, Kathryn S E Cheah, Pak C Sham, Danny Chan
Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etiology of IDD is not well understood. Along with aging and environmental factors, genetic factors also influence the onset, progression and severity of IDD. Genetic studies of risk factors for IDD using human cohorts are limited by small sample size and low statistical power. Animal models amenable to genetic and functional studies of IDD provide desirable alternatives...
April 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29649397/management-of-a-cancer-patient-with-an-intrathecal-drug-delivery-system-and-an-acute-brain-abscess
#16
David R Walega, Marc Korn
Surgical-site infection, spinal cord abscess, and catheter tip granuloma are known but rare complications of intrathecal drug delivery systems (IDDS). To date, there are no published cases of brain abscess in a patient with an IDDS. In this study, we report a case of a cancer patient with an IDDS for management of cancer pain who developed a brain abscess with profound mental status changes and clinical management challenges.
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29626787/enzyme-triggered-size-shrink-and-laser-enhanced-no-release-nanoparticles-for-deep-tumor-penetration-and-combination-therapy
#17
Chuan Hu, Xingli Cun, Shaobo Ruan, Rui Liu, Wei Xiao, Xiaotong Yang, Yuanyuan Yang, Chuanyao Yang, Huile Gao
Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous nature of tumor. Herein, we presented a novel nanoparticle that could not only response to the tumor microenvironment but also modulate it for deep tumor penetration and combination therapy. The intelligent nanoparticle (IDDHN) was engineered by hyaluronidase (HAase)-triggered size shrinkable hyaluronic acid shells, which were modified with NIR laser sensitive nitric oxide donor (HN), small-sized dendrimeric prodrug (IDD) of doxorubicin (DOX) as chemotherapy agent and indocyanine green (ICG) as photothermal agent into a single nanoparticle...
March 27, 2018: Biomaterials
https://www.readbyqxmd.com/read/29621909/on-intellectual-and-developmental-disabilities-in-the-united-states-a-historical-perspective
#18
Jordan A Conrad
The history of intellectual and developmental disabilities (IDD) in the United States is, in many ways, a triumphant story reflecting an increasingly progressive attitude acknowledging the equality of all persons. The law now recognizes people with IDD as citizens, possessing an equal right to education, health care, and employment-each of which represents milestone victories. However, this progression was not a linear development but rather a product of periods of growth and decline, backsliding, and hard-won battles across political, cultural, and legal domains...
January 1, 2018: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29617687/hemeoxygenase-1-suppresses-il-1%C3%AE-induced-apoptosis-through-the-nf-%C3%AE%C2%BAb-pathway-in-human-degenerative-nucleus-pulposus-cells
#19
Chaoying Zhu, Wei Jiang, Qiang Cheng, Zhenming Hu, Jie Hao
BACKGROUND/AIMS: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1 (HO-1) on human NPC apoptosis has never been reported. Our study aimed to investigate the effect and mechanism of HO-1 on apoptosis in human degenerative NPCs. METHODS: Nucleus pulposus tissues were collected from patients with lumbar vertebral fracture (LVF) and IDD...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29607562/risk-factors-and-topographies-for-self-injurious-behaviour-in-a-sample-of-adults-with-intellectual-developmental-disorders
#20
A Folch, M J Cortés, L Salvador-Carulla, P Vicens, M Irazábal, S Muñoz, L Rovira, C Orejuela, J M Haro, E Vilella, R Martínez-Leal
BACKGROUND: Self-injurious behaviour (SIB) is a prevalent form of challenging behaviour in people with intellectual developmental disorders (IDD). Existing research has yielded conflicting findings concerning the major risk factors involved, and in addition, SIB shows multiple topographies and presentations. Although presence of autism spectrum disorders (ASD) and severity of intellectual disability (ID) are known risk factors for SIB, there are no studies comparing SIB topographies by severity degrees of ID and ASD...
April 1, 2018: Journal of Intellectual Disability Research: JIDR
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