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https://www.readbyqxmd.com/read/29466672/the-long-noncoding-rna-snhg1-promotes-nucleus-pulposus-cell-proliferation-through-regulating-mir-326-ccnd1
#1
Hongyu Tan, Liang Zhao, Ruipeng Song, Yilin Liu, Limin Wang
Aberrant nucleus pulposus cell proliferation is implicated in the development of intervertebral disc degeneration (IDD). Recent studies have suggested that long non-coding RNAs (lncRNAs) can modulate cell proliferation in several pathological conditions. Here, we indicated that the expression of SNHG1 was upregulated in IDD tissues compared to the control tissues and higher SNHG1 expression was associated with disc degeneration grade. In addition, we showed that ectopic expression of SNHG1 promoted nucleus pulposus (NP) cell proliferation and increased the PCNA and cyclin D1 expression in NP cell...
February 21, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29446171/retrospective-analysis-of-intrathecal-drug-delivery-outcomes-efficacy-and-risk-for-cancer-related-pain-at-a-high-volume-academic-medical-center
#2
Dawood Sayed, Forrest Monroe, Walter N Orr, Milind Phadnis, Talal W Khan, Edward Braun, Smith Manion, Andrea Nicol
OBJECTIVES: Cancer pain is common and difficult to treat, as conservative medical management fails in approximately 20% of patients for reasons such as intolerable side-effects or failure to control pain. Intrathecal drug delivery systems (IDDS), while underutilized, can be effective tools to treat intractable cancer pain. This study aims to determine the degree of pain relief, efficacy, and safety of patients who underwent IDDS implantation at a multidisciplinary pain clinic. MATERIALS AND METHODS: A retrospective review was conducted of patients with an intrathecal pain pump implanted for malignant pain...
February 14, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29446011/continuously-sustained-elimination-of-iodine-deficiency-a-quarter-of-a-century-success-in-the-islamic-republic-of-iran
#3
H Delshad, P Mirmiran, Z Abdollahi, F Salehi, F Azizi
BACKGROUND: Iodine deficiency and related disorders were very common in Iran prior to 1996, when universal salt iodization (USI) was implemented and in 2000 Iran was declared iodine deficiency disorders (IDD) free. The aim of this study was to evaluate the adequacy of iodine intake by Iranian households in all 30 provinces of Iran, a quarter of a century after the intervention. METHODS: A total of 18,000 school-aged children (8-10 years with mean 8.7 ± 1 year) were included in this study...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29441708/loneliness-in-people-with-intellectual-and-developmental-disorders-across-the-lifespan-a-systematic-review-of-prevalence-and-interventions
#4
REVIEW
Petroutsou Alexandra, Hassiotis Angela, Afia Ali
BACKGROUND: The aim of the study was to conduct the first systematic review investigating the prevalence of loneliness in people with intellectual developmental disabilities (IDD) and the interventions targeting loneliness. METHOD: A search across five databases was conducted (May 2016-June 2016). One reviewer (A. P.) selected the articles for inclusion and assessed their risk of bias using a standardized tool. The second reviewer (A. H.) examined the list of included/excluded articles and the ratings of the studies...
February 14, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29436660/cartilage-intermediate-layer-protein-is-regulated-by-mechanical-stress-and-affects-extracellular-matrix-synthesis
#5
Jinyue He, Chencheng Feng, Jing Sun, Kang Lu, Tongwei Chu, Yue Zhou, Yong Pan
Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP contributes to IDD in humans. Furthermore, the regulation of CILP in human IVDs is poorly understood, especially by mechanical stimuli, which are regarded as primary factors promoting IDD. To address these issues, the present study collected nucleus pulposus (NP) cells from patients undergoing lumbar spinal surgery for degenerative disc disease (DDD)...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29433976/rate-of-deficit-accumulation-in-home-care-users-with-intellectual-and-developmental-disabilities
#6
Hélène Ouellette-Kuntz, Lynn Martin, Katherine McKenzie
PURPOSE: To identify factors associated with the rate of deficit accumulation in a population of adults with intellectual and developmental disabilities (IDD). METHODS: A longitudinal analysis of administratively held clinical data collected at routine home care assessments across Ontario (Canada) using the Resident Assessment Instrument for Home Care (RAI-HC) was conducted using a cohort comprised of 5074 adults with IDD 18-99 years of age who had at least two home care assessments between April 1, 2003 and March 31, 2015...
January 31, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29433315/factors-controlling-drug-release-in-cross-linked-poly-valerolactone-based-matrices
#7
Frantz Le Devedec, Hilary Boucher, David N Dubins, Christine Allen
There is keen interest in the development of biocompatible and biodegradable implantable delivery systems (IDDS) that provide sustained drug release for prolonged periods in humans. These systems have the potential to enhance therapeutic outcomes, reduce systemic toxicity and improve patient compliance. Herein, we report the preparation and physico-chemical characterization of cross-linked polymeric matrices from poly(valerolactone)-co-poly(allyl-δ-valerolactone) (PVL-co-PAVL) copolymers for use in drug delivery...
February 13, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29428208/gender-differences-in-tobacco-use-among-u-s-special-olympics-athletes
#8
Elaine Eisenbaum, Diana M DiNitto, Lauren Bishop-Fitzpatrick
BACKGROUND: The rise in women's tobacco use and subsequent health complications has generated an increase in gender-related tobacco use research. However, no research has examined gender's influence on tobacco use among people with intellectual and developmental disabilities (IDD). OBJECTIVE: To examine 1) tobacco use prevalence rates among men and women with IDD, and 2) correlates of tobacco use among men and women with IDD. METHODS: This study examined gender differences in tobacco use among a sample of 3587 adult U...
February 1, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29427860/health-care-expenditures-of-overweight-and-obese-u-s-adults-with-intellectual-and-developmental-disabilities
#9
Henan Li, Glenn Fujiura, Sandra Magaña, Susan Parish
BACKGROUND: U.S. adults with intellectual and developmental disabilities (IDD) have poorer health status and greater risks for being overweight and obese, which are major drivers of health care expenditures in the general population. Health care expenditures and IDD have not been studied using nationally representative samples, and the impact of overweight and obesity have not been examined. AIM: Using nationally representative data, we aimed to compare the health care expenditures of not-overweight, overweight and obese U...
February 7, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29426389/occupational-therapy-in-medicaid-home-and-community-based-services-waivers
#10
Carli Friedman, Laura VanPuymbrouck
OBJECTIVE: Medicaid Home and Community-Based Services (HCBS) 1915(c) waivers are the largest provider of long-term services and supports for people with intellectual and developmental disabilities (IDDs). In this study, we explored how HCBS IDD waivers projected providing occupational therapy services in Fiscal Year (FY) 2015. METHOD: Medicaid HCBS IDD waivers across the nation gathered from the Centers for Medicare and Medicaid Services were qualitatively and quantitatively analyzed to determine how they projected providing occupational therapy services in terms of service expenditures and utilization...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29416763/dysregulation-of-yap-by-the-hippo-pathway-is-involved-in-intervertebral-disc-degeneration-cell-contact-inhibition-and-cell-senescence
#11
Cong Zhang, Feng Wang, Zhiyang Xie, Lu Chen, Arjun Sinkemani, Haomin Yu, Kun Wang, Lu Mao, Xiaotao Wu
The Hippo pathway plays important roles in wound healing, tissue repair and regeneration, and in the treatment of degenerative diseases, by regulating cell proliferation and apoptosis in mammals. Intervertebral disc degeneration (IDD) is one of the major causes of low back pain, a widespread issue associated with a heavy economic burden. However, the mechanism underlying how the Hippo pathway regulates IDD is not well understood. Here, we demonstrate that the Hippo pathway is involved in natural IDD. Activation and dephosphorylation of yes-associated protein (YAP) were observed in younger rat discs, and decreased gradually with age...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414382/interictal-dysphoric-disorder-further-doubts-about-its-epilepsy-specificity-and-its-independency-from-common-psychiatric-disorders
#12
Kirsten Labudda, Dominik Illies, Christian G Bien, Frank Neuner
PURPOSE: The interictal dysphoric disorder (IDD) is a proposed epilepsy-specific psychiatric condition characterized by a conglomerate of symptoms such as depression, irritability, euphoria, and anxiety. However, there are doubts about IDD as an independent entity and about its presumed epilepsy-specific nature. METHODS: Here, we investigated the association between psychiatric disorders and IDD in 120 patients with epilepsy, also analyzing potential associations between IDD symptoms and epilepsy-related variables...
January 29, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29398883/adverse-side-effects-of-psychotropic-medication-and-challenging-behavior-pilot-work-assessing-impact
#13
Maria G Valdovinos, Elizabeth Schieber, Meara McMahon, Lisa Beard, Alyssa Wilkinson, Jaimie Carpenter
Psychotropic medications are often prescribed to reduce challenging behavior in individuals with intellectual and developmental disabilities (IDD). Functional analyses (FAs) have demonstrated utility in assessing medication impact on behavior; however, the impact of adverse side effects (ASE) on challenging behavior is under-assessed. The purpose of this study was to develop a methodology, similar to FAs, to explore potential medication ASE impact on challenging behavior in seven individuals with IDD. Results revealed response rate differences in designed ASE conditions for most participants...
December 2017: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/29393545/bu-shen-huo-xue-fang-bshxf-modulates-nucleus-pulposus-cell-proliferation-and-extracellular-matrix-ecm-remodeling-in-intervertebral-disc-degeneration-through-mir-483-regulation-of-wnt-pathway
#14
Shaofeng Yang, Linghui Li, Liguo Zhu, Chao Zhang, Zhaoyong Li, Yantao Guo, Ying Nie, Zhenhua Luo
Intervertebral disc degeneration (IDD) has been widely considered as one of the main causes for low back pain (LBP) which can cause severe impact to human health and huge economic burden to worldwide society. IDD pathogenesis can be affected by extensive degradation of extracellular matrix (ECM) and the hyperproliferation of nucleus pulposus (NP) cell. During IDD process, ECM degradation enzymes MMP and ADAMTS expression increases, while ECM synthesis-related Aggrecan and COL2A1 expression decreases. In addition, Wnt signaling pathway is reportedly involved in the process of IDD...
February 2, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29389260/reproductive-cancer-treatment-hospitalizations-of-u-s-women-with-intellectual-and-developmental-disabilities
#15
Susan L Parish, Esther Son, Robyn M Powell, Leah Igdalsky
There is a dearth of existing research on the treatment of reproductive cancers among women with intellectual and developmental disabilities (IDD). This study analyzed the 2010 Healthcare Cost and Utilization Project Nationwide Inpatient Sample and compared the prevalence of reproductive cancer treatment hospitalization discharges among women with and without IDD. Discharges linked to women with IDD had higher incidences of cancer of the uterus and lower prevalence of cancer of the cervix. Moreover, discharges linked to women with IDD indicated these women were younger, had longer hospital stays, and were more likely to have public insurance coverage...
February 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29389259/participant-direction-for-people-with-intellectual-and-developmental-disabilities-in-medicaid-home-and-community-based-services-waivers
#16
Carli Friedman
Participant direction allows people with intellectual and developmental disabilities (IDD) and/or their families to direct services; in doing so, participant direction shifts participants from passive recipients to active consumers. Medicaid encourages, but does not require, states to allow participant direction. The aim of this study was to examine if and how states permitted participant direction in Medicaid HCBS 1915(c) waivers for people with IDD. We analyzed HCBS waivers from across the country to determine frequency of participant direction, expenditures directed toward participant direction, and states' goals for utilization of participant direction...
February 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29389256/use-of-transition-resources-by-primary-care-providers-for-youth-with-intellectual-and-developmental-disabilities
#17
Paul B Dressler, Teresa K Nguyen, Eric J Moody, Sandra L Friedman, Laura Pickler
Youth with intellectual and developmental disabilities (IDD) often experience difficulties with successful transition from pediatric to adult healthcare. A consultative Transition Clinic for youth with IDD was piloted as a quality improvement project, and assessed the engagement of primary care providers (PCPs) for transition planning after patients were seen in clinic. Although many PCPs found the clinic and resources useful, individual and systemic barriers often prohibited them from participating in transition planning for this patient population...
February 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29384930/multiple-cerebral-gliomas-mimicking-central-nervous-system-inflammatory-demyelinating-diseases-a-rare-case-with-review-of-literature
#18
Yong-Jie Xiong, Xin-Ling Zhao, Xiao-Yan Wang, Deng-Ji Pan, Dai-Shi Tian
RATIONALE: Multiple cerebral gliomas (MCGs), usually classified into multifocal and multicentric subtypes, represent major diagnostic challenges as their clinical, radiologic, and pathohistological features are not uniform, often mimicking brain metastatic tumors or central nervous system inflammatory demyelinating diseases (IDD). PATIENT CONCERNS: Here, we report a rare case of MCGs with isolated seizures and 4 lesions in the brain, that was initially misdiagnosed as IDD during treatment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379999/lumbar-paraspinal-muscle-fat-infiltration-is-independently-associated-with-sex-age-and-inter-vertebral-disc-degeneration-in-symptomatic-patients
#19
Julio Urrutia, Pablo Besa, Daniel Lobos, Mauricio Campos, Cristobal Arrieta, Marcelo Andia, Sergio Uribe
PURPOSE: To determine the association of paraspinal muscles and psoas relative cross-sectional area (RCSA) and fat signal fraction (FSF) with sex, age, and intervertebral disc degeneration (IDD) in symptomatic patients. METHODS: We retrospectively evaluated 80 adult patients with spinal symptoms using T2-weighted magnetic resonance images. We determined RCSA and FSF of the paraspinal muscles (erector spinae and multifidus) and psoas from L1-L2 to L5-S1; we determined IDD using the Pfirrmann classification...
January 29, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29370869/a-new-enzyme-linked-immunosorbent-assay-for-neurofilament-light-in-cerebrospinal-fluid-analytical-validation-and-clinical-evaluation
#20
Lorenzo Gaetani, Kina Höglund, Lucilla Parnetti, Fani Pujol-Calderon, Bruno Becker, Paolo Eusebi, Paola Sarchielli, Paolo Calabresi, Massimiliano Di Filippo, Henrik Zetterberg, Kaj Blennow
BACKGROUND: Cerebrospinal fluid (CSF) neurofilament light (NfL) is a reliable marker of neuro-axonal damage in different neurological disorders that is related to disease severity. To date, all recent studies performed in human CSF have used the same enzyme-linked immunosorbent assay (ELISA). To confirm the large body of evidence for NfL, we developed a new ELISA method and here we present the performance characteristics of this new ELISA for CSF NfL in different neurological disorders...
January 23, 2018: Alzheimer's Research & Therapy
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