keyword
MENU ▼
Read by QxMD icon Read
search

IDD

keyword
https://www.readbyqxmd.com/read/27895224/nkd-transcription-factors-are-central-regulators-of-maize-endosperm-development
#1
Bryan C Gontarek, Anjanasree K Neelakandan, Hao Wu, Philip W Becraft
NAKED ENDOSPERM1 (NKD1) and NKD2 are duplicate INDETERMINATE DOMAIN (IDD) transcription factors important for maize (Zea mays) endosperm development. RNAseq analysis of the nkd1 nkd2 mutant endosperm revealed that NKD1 and NKD2 influence 6.4% of the transcriptome in developing aleurone and 6.7% in starchy endosperm. Processes regulated by NKD1 and NKD2 include gene expression, epigenetic functions, cell growth and division, hormone pathways and resource reserve deposition. The NKD1 and NKD2 proteins bind a consensus DNA sequence of TTGTCGT with slightly different properties...
November 28, 2016: Plant Cell
https://www.readbyqxmd.com/read/27893410/characterization-of-variations-in-il23a-and-il23r-genes-possible-roles-in-multiple-sclerosis-and-other-neuroinflammatory-demyelinating-diseases
#2
Fei-Feng Li, Xi-Dong Zhu, Peng Yan, Mei-Hua Jin, Hui Yue, Qiong Zhang, Jin Fu, Shu-Lin Liu
Multiple sclerosis is among the most serious inflammatory demyelinating diseases (IDD). Interleukin-23A (IL23A) regulates and coordinates the activities of immune cells by interacting with its receptor IL23R and plays key roles in the pathogenesis of immune inflammatory diseases. IDD, deemed to be a kind of autoimmune diseases, may involve IL23A in the pathogenesis. The aim of this work was to validate the hypothesized involvement of IL-23A and its receptor in IDD. We sequenced the IL-23A and IL-23R genes for 206 Chinese Han IDD patients and evaluated SNPs within or near those genes...
November 26, 2016: Aging
https://www.readbyqxmd.com/read/27893313/issues-in-the-medication-management-process-in-people-who-have-intellectual-and-developmental-disabilities-a-qualitative-study-of-the-caregivers-perspective
#3
Steven R Erickson, Teresa M Salgado, Xi Tan
People who have intellectual and developmental disabilities (IDD) often rely on caregivers to assist in the medication management process. The aim of this study was to learn from caregivers, who are either family or support staff, what major issues arise throughout the process of managing medication and how these might be addressed. Problems identified by caregivers include (a) prescribers understanding of insurance and agency policies regarding medication utilization; (b) lack of continuity of care and accuracy of the medication record as well as clinical records;...
December 2016: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/27893311/more-job-services-better-employment-outcomes-increasing-job-attainment-for-people-with-idd
#4
Derek Nord
Job search, job placement, and on-the-job supports are valuable services provided to many people with intellectual and developmental disabilities (IDD) to obtain work in the community. Investigating those who were unemployed at the time of service entry, this study seeks to extend understanding about the effect of services. Using extant data, a sample of 39,277 people with IDD using Vocational Rehabilitation services were studied to understand the potential cumulative effects of these job-related services and individual characteristics on job attainment...
December 2016: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/27891762/judicial-reliance-on-parental-iq-in-appellate-level-child-welfare-cases-involving-parents-with-intellectual-and-developmental-disabilities
#5
Ella Callow, Munazza Tahir, Maurice Feldman
BACKGROUND: Parents with intellectual and developmental disabilities (IDDs) are over-represented in child welfare cases. Although IQ per se is an invalid indicator of parenting abilities, this study examined the prevalence of judicial consideration of parental IQ test evidence in US appellate cases. METHODS: The present authors conducted Boolean searches of Westlaw Corporation's case database since 1999. The present authors used a six-question checklist to survey the 42 most recent American appellate cases involving termination of parental rights (TPR) decisions that included evidence of parental intellectual and developmental disabilities based on IQ...
November 27, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27887889/development-of-intramammary-drug-delivery-systems-novel-in-vitro-release-method
#6
Sanjay Garg, Wen Wang, Yunmei Song, Patricia Eats, Darren J Trott, Stephen W Page, Kiro Petrovski
The aim of this study was to develop an in vitro release model for intramammary drug delivery system (IDDS) evaluation. This study was the first to establish an in vitro-in vivo correlation with investigation of IDDS containing losalocid. Three different methods including standard USP dissolution method with apparatus 2, modified USP method by using a dialysis bag or by using a specific designed enhancer cell system were assessed for the release study. Full cream milk and water were selected as the release media...
November 22, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27873140/cross-cultural-validity-of-the-social-communication-questionnaire-for-adults-with-intellectual-developmental-disorder
#7
Tanja Sappok, Whitney Brooks, Manuel Heinrich, Jane McCarthy, Lisa Underwood
Diagnosing Autism Spectrum Disorders (ASD) is important throughout the lifespan. The objective was to investigate the transcultural diagnostic validity of the Social Communication Questionnaire (SCQ) in a clinical sample of 451 adults with Intellectual Developmental Disorder (IDD) with and without ASD in Germany, the U.S.A. and Great Britain. Variables associated with higher SCQ sum-scores were higher levels of IDD, male gender, a diagnosis of ASD and the study site (Germany > U.S.A > G.B.). An ROC analysis revealed a cut-score of 13, which resulted in a sensitivity of 0...
November 21, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27871028/microstructure-analysis-method-for-evaluating-degenerated-intervertebral-disc-tissue
#8
Andrea Friedmann, Felix Goehre, Christopher Ludtka, Thomas Mendel, Hans-Joerg Meisel, Andreas Heilmann, Stefan Schwan
Degeneration of intervertebral disc (IVD) tissue is characterized by several structural changes that result in variations in disc physiology and loss of biomechanical function. The complex process of degeneration exhibits highly intercorrelated biomechanical, biochemical, and cellular interactions. There is currently some understanding of the cellular changes in degenerated intervertebral disc tissue, but microstructural changes and deterioration of the tissue matrix has previously been rarely explored. In this work, sequestered IVD tissue was successfully characterized using histology, light microscopy, and scanning electron microscopy (SEM) to quantitatively evaluate parameters of interest for intervertebral disc degeneration (IDD) such as delamination of the collagenous matrix, cell density, cell size, and extra cellular matrix (ECM) thickness...
October 21, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27864283/tumor-necrosis-factor-%C3%AE-a-key-contributor-to-intervertebral-disc-degeneration
#9
REVIEW
Cheng Wang, Xiaohua Yu, Yiguo Yan, Wei Yang, Shujun Zhang, Yongxiao Xiang, Jian Zhang, Wenjun Wang
Intervertebral disc (IVD) degeneration (IDD) is the most common cause leading to low back pain (LBP), which is a highly prevalent, costly, and crippling condition worldwide. Current treatments for IDD are limited to treat the symptoms and do not target the pathophysiology. Tumor necrosis factor-α (TNF-α) is one of the most potent pro-inflammatory cytokines and signals through its receptors TNFR1 and TNFR2. TNF-α is highly expressed in degenerative IVD tissues, and it is deeply involved in multiple pathological processes of disc degeneration, including matrix destruction, inflammatory responses, apoptosis, autophagy, and cell proliferation...
November 17, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27859817/lncrnas-novel-players-in-intervertebral-disc-degeneration-and-osteoarthritis
#10
REVIEW
Wen-Kang Chen, Xiao-Hua Yu, Wei Yang, Cheng Wang, Wen-Si He, Yi-Guo Yan, Jian Zhang, Wen-Jun Wang
The term long non-coding RNA (lncRNA) refers to a group of RNAs with length more than 200 nucleotides, limited protein-coding potential, and having widespread biological functions, including regulation of transcriptional patterns and protein activity, formation of endogenous small interfering RNAs (siRNAs) and natural microRNA (miRNA) sponges. Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders. Numbers of lncRNAs are differentially expressed in human degenerative nucleus pulposus tissue and OA cartilage...
November 9, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27855220/disease-type-and-status-specific-alteration-of-csf-metabolome-coordinated-with-clinical-parameters-in-inflammatory-demyelinating-diseases-of-cns
#11
Soo Jin Park, In Hye Jeong, Byung Soo Kong, Jung-Eun Lee, Kyoung Heon Kim, Do Yup Lee, Ho Jin Kim
Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) are a group of disorders with different aetiologies, characterized by inflammatory lesions. These disorders include multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and idiopathic transverse myelitis (ITM). Differential diagnosis of the CNS IDDs still remains challenging due to frequent overlap of clinical and radiological manifestation, leading to increased demands for new biomarker discovery. Since cerebrospinal fluid (CSF) metabolites may reflect the status of CNS tissues and provide an interfacial linkage between blood and CNS tissues, we explored multi-component biomarker for different IDDs from CSF samples using gas chromatography mass spectrometry-based metabolite profiling coupled to multiplex bioinformatics approach...
2016: PloS One
https://www.readbyqxmd.com/read/27848245/inflammatory-mediators-and-signalling-pathways-controlling-intervertebral-disc-degeneration
#12
REVIEW
Stefania Elena Navone, Giovanni Marfia, Amedeo Giannoni, Matteo Beretta, Laura Guarnaccia, Roberta Gualtierotti, Daniele Nicoli, Paolo Rampini, Rolando Campanella
Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a condition that represents a serious socio-economic burden. Deeper knowledge of the complex and fine relationship between IVD degeneration, tissue inflammation and pain, appears to be critical to improve the current therapies, which have so far proven themselves ineffective. Upon degeneration, IVD tissues become inflamed, and this inflammatory microenvironment is associated with a cascade of degenerative events that may eventually cause discogenic pain...
November 16, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27826214/clinical-outcome-following-diam-implantation-for-symptomatic-lumbar-internal-disk-disruption-a-3-year-retrospective-analysis
#13
Kang Lu, Po-Chou Liliang, Hao-Kuang Wang, Jui-Sheng Chen, Te-Yuan Chen, Ruyi Huang, Han-Jung Chen
BACKGROUND/OBJECTIVE: Internal disk disruption (IDD), an early event of lumbar disk degeneration, is the most common cause of low back pain. Since increased intradiskal pressure (IDP) is associated with symptoms and progression of disk degeneration, unloading a painful disk with an interspinous process device (IPD) is a rational treatment option. The goal of this study was to evaluate the effectiveness of dynamic stabilization with an IPD in the treatment of symptomatic IDD of the lumbar spine...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27818061/young-children-who-screen-positive-for-autism-stability-change-and-comorbidity-over-two-years
#14
Anne-Katrin Kantzer, Elisabeth Fernell, Joakim Westerlund, Bibbi Hagberg, Christopher Gillberg, Carmela Miniscalco
BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder with a wide variety of clinical phenotypes and co-occurrences with other neurodevelopmental conditions. Symptoms may change over time. AIMS: The aim of the present study was to prospectively follow 96 children, initially assessed for suspected ASD at an average age of 2.9 years. METHODS AND PROCEDURES: All children had been identified with autistic symptoms in a general population child health screening program, and had been referred to the Child Neuropsychiatry Clinic in Gothenburg, Sweden for further assessment by a multi-professional team at Time 1 (T1)...
November 3, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27810602/weight-management-for-adolescents-with-intellectual-and-developmental-disabilities-rationale-and-design-for-an-18month-randomized-trial
#15
J E Donnelly, L T Ptomey, J R Goetz, D K Sullivan, C A Gibson, J L Greene, R H Lee, M S Mayo, J J Honas, R A Washburn
Adolescents with intellectual and developmental disabilities (IDD) are an underserved group in need of weight management. However, information regarding effective weight management for this group is limited, and is based primarily on results from small, non-powered, non-randomized trials that were not conducted in accordance with current weight management guidelines. Additionally, the comparative effectiveness of emerging dietary approaches, such as portion-controlled meals (PCMs) or program delivery strategies such as video chat using tablet computers have not been evaluated...
October 31, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27807587/two-cases-of-intraluminal-windsock-diverticula-resulting-in-partial-duodenal-obstruction
#16
Vikram Anand, Justin Provost, Maged Bakr, Christopher Bach, Prakriti Merchant, Christopher Brown, Claudia Gruss
An intraluminal duodenal diverticulum (IDD) is a rare congenital anomaly that is the result of incomplete recanalization of the embryologic foregut leaving a fenestrated membrane within the lumen of the duodenum. Years of peristalsis acting on the membrane result in the formation of a diverticulum. Most patients are asymptomatic, while some may have abdominal pain, bloating, or fullness. Rare complications include gastrointestinal bleeding, obstruction, pancreatitis, and cholangitis. We present 2 cases with endoscopic findings consistent with partially obstructing symptomatic IDD...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27803063/the-role-of-%C3%AE-4-integrin-in-theiler-s-murine-encephalomyelitis-virus-tmev-induced-demyelinating-disease-an-infectious-animal-model-for-multiple-sclerosis-ms
#17
Yuta Hirano, Kunitoshi Kobayashi, Hiroki Tomiki, Yuhji Inaba, Motoki Ichikawa, Byung S Kim, Chang-Sung Koh
Natalizumab, which is an antibody against α4 integrin, has been used for the treatment of multiple sclerosis (MS). In the present study, we investigated both the role of α4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small-molecule α4 integrin antagonist, in the development of TMEV-induced demyelinating disease (TMEV-IDD). The mRNA levels of α4 integrins were significantly up-regulated in the CNS of mice with TMEV-IDD as compared with naïve mice (*p<0.05). HCA3551 treatment in the effector phase significantly suppressed both the clinical and histological development of TMEV-IDD...
November 1, 2016: International Immunology
https://www.readbyqxmd.com/read/27802103/food-insecurity-among-young-adults-with-intellectual-and-developmental-disabilities-in-the-united-states-evidence-from-the-national-health-interview-survey
#18
Debra L Brucker, Derek Nord
People with intellectual or developmental disabilities (IDD) face higher levels of poverty than others, which can lead to concerns regarding areas of well-being, such as food security. Young adults with IDD who are, in many cases, transitioning from the system of educational, health care, and income supports of their youth into the adult world may be particularly vulnerable. Using pooled data from the 2011-2014 National Health Interview Survey, we find that young adults with IDD have significantly higher levels of food insecurity than young adults without disabilities, even when controlling for poverty...
November 2016: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/27787519/metformin-protects-against-apoptosis-and-senescence-in-nucleus-pulposus-cells-and-ameliorates-disc-degeneration-in-vivo
#19
Deheng Chen, Dongdong Xia, Zongyou Pan, Daoliang Xu, Yifei Zhou, Yaosen Wu, Ningyu Cai, Qian Tang, Chenggui Wang, Meijun Yan, Jing Jie Zhang, Kailiang Zhou, Quan Wang, Yongzeng Feng, Xiangyang Wang, Huazi Xu, Xiaolei Zhang, Naifeng Tian
Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeutic effect on IDD through autophagy stimulation. The effect of metformin on IDD was investigated both in vitro and in vivo. Our study showed that metformin attenuated cellular apoptosis and senescence induced by tert-butyl hydroperoxide in nucleus pulposus cells...
October 27, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27774108/a-controlled-release-codelivery-system-of-mscs-encapsulated-in-dextran-gelatin-hydrogel-with-tgf-%C3%AE-3-loaded-nanoparticles-for-nucleus-pulposus-regeneration
#20
Yibo Gan, Sukai Li, Pei Li, Yuan Xu, Liyuan Wang, Chen Zhao, Bin Ouyang, Bing Tu, Chengmin Zhang, Lei Luo, Xiangdong Luo, Xiumei Mo, Qiang Zhou
Mesenchymal stem cell- (MSC-) based therapy is regarded as a potential tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to induce MSC differentiation in NP-like cells when MSCs are implanted into the NP. The purpose of this study was to construct poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles as carriers for TGF-β3 controlled release and establish a codelivery system of a dextran/gelatin hydrogel with the nanoparticles for long-term processing of discogenesis differentiation...
2016: Stem Cells International
keyword
keyword
23928
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"