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Approach to a thyroid nodule

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https://www.readbyqxmd.com/read/28071986/evaluation-of-a-two-year-routine-application-of-molecular-testing-of-thyroid-fine-needle-aspirations-fna-using-a-7-gene-panel-in-a-primary-referral-setting-in-germany
#1
Markus Eszlinger, Katharina Böhme, Maha Ullmann, Fabian Görke, Udo Siebolts, Anna Neumann, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ilka Ruschenburg, Ralf Paschke
BACKGROUND: Major differences with respect to the diagnostic performance of a "ruling in" approach in the pre-surgical diagnosis of indeterminate thyroid fine needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a 7-gene-panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany. METHODS: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28064410/detecting-n-ras-q61r-mutated-thyroid-neoplasias-by-immunohistochemistry
#2
A Crescenzi, F Fulciniti, M Bongiovanni, L Giovanella, Pierpaolo Trimboli
Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled. Paraffin sections were stained for IHC using the rabbit monoclonal anti-human N-RAS Q61R, clone SP174. N-RAS mutations in codon 61 were also investigated by automated sequencing. At histology, 12 cases of follicular carcinoma, cytologically defined as follicular lesions, 1 papillary cancer, 7 follicular adenomas, and 4 hyperplastic nodules were found...
January 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28028762/screening-for-thyroid-cancer-in-survivors-of-childhood-and-young-adult-cancer-treated-with-neck-radiation
#3
Emily S Tonorezos, Dana Barnea, Chaya S Moskowitz, Joanne F Chou, Charles A Sklar, Elena B Elkin, Richard J Wong, Duan Li, R Michael Tuttle, Deborah Korenstein, Suzanne L Wolden, Kevin C Oeffinger
BACKGROUND: The optimal method of screening for thyroid cancer in survivors of childhood and young adult cancer exposed to neck radiation remains controversial. Outcome data for a physical exam-based screening approach are lacking. METHODS: We conducted a retrospective review of adult survivors of childhood and young adult cancer with a history of neck radiation followed in the Adult Long-Term Follow-Up Clinic at Memorial Sloan Kettering between November 2005 and August 2014...
December 27, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27965276/thyroid-nodules-and-cancer-management-guidelines-comparisons-and-controversies
#4
REVIEW
Fadi Nabhan, Matthew D Ringel
Thyroid cancer is an increasingly prevalent malignancy throughout the world. Management guidelines for both thyroid nodules and thyroid cancer have been published and updated by a number of societies internationally. All of these guidelines recognize this increasing incidence, particularly of small papillary thyroid cancers, due in part to improved technology enabling early or even 'over' diagnosis. Recent advances in molecular imaging and molecular methods have been developed to better characterize thyroid nodules, and a number of studies that have clarified risk stratification systems that can be modified over time allow for individualization of diagnosis, initial treatment, and subsequent follow-up strategies...
February 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27928729/the-total-number-of-tissue-blocks-per-centimetre-of-tumor-significantly-correlated-with-the-risk-of-distant-metastasis-in-patients-with-minimally-invasive-follicular-thyroid-carcinoma
#5
Brian Hung-Hin Lang, Tony W H Shek, Arnold L H Wu, Koon Yat Wan
BACKGROUND: Given that careful histological examination plays a pivotal role in follicular thyroid carcinoma categorization, we hypothesize that the number of blocks taken at initial specimen review may be associated with survival outcomes of patients initially diagnosed with minimally invasive follicular thyroid carcinoma. METHODS: A total of 162 patients with confirmed minimally invasive follicular thyroid carcinoma were analyzed. The number of tissue blocks taken from each patient was recorded and the number of blocks per each centimeter of tumor was calculated...
December 7, 2016: Endocrine
https://www.readbyqxmd.com/read/27908169/flexible-mini-gamma-camera-reconstructions-of-extended-sources-using-step-and-shoot-and-list-mode
#6
José Gardiazabal, Philipp Matthies, Jakob Vogel, Benjamin Frisch, Nassir Navab, Sibylle Ziegler, Tobias Lasser
PURPOSE: Hand- and robot-guided mini gamma cameras have been introduced for the acquisition of single-photon emission computed tomography (SPECT) images. Less cumbersome than whole-body scanners, they allow for a fast acquisition of the radioactivity distribution, for example, to differentiate cancerous from hormonally hyperactive lesions inside the thyroid. This work compares acquisition protocols and reconstruction algorithms in an attempt to identify the most suitable approach for fast acquisition and efficient image reconstruction, suitable for localization of extended sources, such as lesions inside the thyroid...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27900100/avoidance-of-unnecessary-fine-needle-aspiration-with-the-use-of-the-thyroid-imaging-reporting-data-system-classification-and-strain-elastography-based-on-the-bethesda-system-for-reporting-thyroid-cytopathology
#7
Murat Erkan, Sule Canberk, Gamze Z Kilicoglu, Mine Onenerk, Atay Uludokumaci, Pembegul Gunes, Tugba Atasoy
Thyroid fine-needle aspiration (FNA) biopsy has been widely accepted as an accurate and cost-effective tool in the management of thyroid nodules. To avoid unnecessary FNAs and provide appropriate management, patient evaluation should be based on a multidisciplinary approach. For this purpose, the Thyroid Imaging Reporting and Data System (TI-RADS) and strain elastography (SE) were proposed as tools for the risk assessment of malignancy in thyroid nodules. The aim of the present study was to analyze the utility of TI-RADS system and SE, along with FNA, and prospectively evaluate 369 consecutive patients referred for FNA of a thyroid nodule...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27883069/quality-of-life-and-cost-effectiveness-of-radiofrequency-ablation-versus-open-surgery-for-benign-thyroid-nodules-a-retrospective-cohort-study
#8
Wen-Wen Yue, Xiao-Long Li, Hui-Xiong Xu, Feng Lu, Li-Ping Sun, Le-Hang Guo, Ya-Ping He, Dan Wang, Zhi-Qiang Yin
This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849384/assessing-referrals-and-improving-information-availability-for-consultations-in-an-academic-endocrinology-clinic
#9
Chase D Hendrickson, Saumya Saini, Avin Pothuloori, John N Mecchella
OBJECTIVE: Outpatient specialty consultations rely on the timeliness and completeness of referral information to facilitate a valuable patient-specialist interaction. This project aimed to increase essential diagnostic information availability at the initial consultation for patients referred for common endocrine conditions frequently lacking such data - diabetes mellitus, thyroid nodule, thyrotoxicosis, and hypercalcemia. METHODS: At an endocrinology clinic at an academic medical center in rural New England, providers see several thousand new patients annually, the majority of whom are referred by providers external to the clinic's healthcare system...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27832468/nodular-thyroid-disease-in-the-elderly-novel-molecular-approaches-for-the-diagnosis-of-malignancy
#10
REVIEW
Salvatore Sorrenti, Enke Baldini, Francesco Tartaglia, Antonio Catania, Stefano Arcieri, Daniele Pironi, Pier Giorgio Calò, Angelo Filippini, Salvatore Ulisse
Epithelial thyroid cancers (TC) comprise two differentiated histotypes (DTC), the papillary (PTC) and the follicular (FTC) thyroid carcinomas which, following dedifferentiation, are assumed to give rise to the poorly differentiated thyroid carcinomas and the rare, but highly aggressive and invariably fatal, anaplastic thyroid carcinomas. Although thyroid cancer mortality has not been changed, its annual incidence has increased over the last two decades, mainly because of the improved ability to diagnose malignant transformation in small non-palpable thyroid nodules...
November 10, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27793213/a-panel-of-four-genes-accurately-differentiates-benign-from-malignant-thyroid-nodules
#11
Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Quan Li, Yi-Xiang Jin, Wen-Xu Jin, Ying-Hao Wang, Zhou-Ci Zheng, Lu Xue, Ou-Chen Wang, Xiao-Hua Zhang
BACKGROUND: Clinicians are confronted with an increasing number of patients with thyroid nodules. Reliable preoperative diagnosis of thyroid nodules remains a challenge because of inconclusive cytological examination of fine-needle aspiration biopsies. Although molecular analysis of thyroid tissue has shown promise as a diagnostic tool in recent years, it has not been successfully applied in routine clinical use, particularly in Chinese patients. METHODS: Whole-transcriptome sequencing of 19 primary papillary thyroid cancer (PTC) samples and matched adjacent normal thyroid tissue (NT) samples were performed...
October 28, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27770838/thyroid-gland-metastasis-from-cancer-of-the-uterine-cervix-an-extremely-rare-case-report
#12
Suleyman Utku Celik, Dilara Besli, Serpil Dizbay Sak, Volkan Genc
The thyroid gland is a relatively uncommon site for a metastatic disease, although it is richly supplied with blood. The metastases may originate from various primary sites, mainly kidney, lung, head and neck, and breast. Thyroid metastasis from cervical carcinomas is extremely rare; and only a few cases have been previously reported in the literature. In patient with thyroid nodules and an oncological history, the possibility of thyroid metastasis should be seriously considered. Despite the rarity of the metastasis of cervical carcinoma to the thyroid, it is difficult to say appropriate treatment approach for these lesions...
2016: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/27745544/pediatric-differentiated-thyroid-cancer-when-to-perform-conservative-and-radical-surgery
#13
Claudio Spinelli
Thyroid tumors affect all age groups, including children and adolescents. Malignant cancer of the thyroid is a relatively uncommon disease in pediatric age. In the recent decades the incidence of paediatric differentiated thyroid carcinoma (DTC) has increased. DTC in paediatric age is rare and has an excellent prognosis. Compared to adult counterpart, DTC in childhood presents some different features as follows: larger volume at the diagnosis, more frequent multicentricity (both mono- and bilateral), earlier local involvement of soft tissue of the neck, earlier lymph node involvement, distant metastases 3-4 times more frequent (most often in the lungs and almost always functional) and more common post-operatory recurrence; nevertheless, the prognosis of DTC in childhood is better and the survival greater than in adult...
October 13, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27742787/thyroid-cancer-risk-stratified-management-and-individualized-therapy
#14
EDITORIAL
Friedhelm Raue, Karin Frank-Raue
Thyroid cancer is the most common endocrine malignancy. Differentiated thyroid cancer (DTC) with the two subtypes, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC), is the most frequent subtype of thyroid cancer; more rare subtypes are medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC). The incidence of DTC has increased rapidly in recent years due to the more frequent use of imaging methods such as ultrasound of the neck and fine-needle aspiration (FNA) of thyroid nodules...
October 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27738835/remote-access-robotic-facelift-thyroidectomy-a-multi-institutional-experience
#15
William S Duke, F Christopher Holsinger, Emad Kandil, Jeremy D Richmon, Michael C Singer, David J Terris
BACKGROUND: Robotic facelift thyroidectomy (RFT) was developed as a new surgical approach to the thyroid gland using a remote incision site. Early favorable results led to this confirmatory multi-institutional experience. METHODS: Prospectively collected data on consecutive patients undergoing RFT in five North American academic endocrine surgical practices were compiled. Surgical indications, operative times, final pathology, nodule size, complications, and postoperative management (drain use and length of hospital stay) were evaluated...
January 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/27717198/young-investigator-challenge-can-the-ion-ampliseq-cancer-hotspot-panel-v2-be-used-for-next-generation-sequencing-of-thyroid-fna-samples
#16
Claudio Bellevicine, Roberta Sgariglia, Umberto Malapelle, Elena Vigliar, Mariantonia Nacchio, Giuseppe Ciancia, Markus Eszlinger, Ralf Paschke, Giancarlo Troncone
BACKGROUND: Fine-needle aspiration (FNA) cytology is accurate and cost-effective in the evaluation of thyroid nodules. Molecular techniques may contribute to risk stratification in indeterminate cases. Although next-generation sequencing (NGS) is a promising technique for the molecular testing of thyroid FNA specimens, thyroid-specific cancer gene panels are not commercially available. Conversely, the Ion AmpliSeq Cancer Hotspot Panel v2 (CHPv2), which includes the genes most frequently mutated in thyroid neoplasms, is commercially available and may represent an alternative to thyroid-specific panels...
November 2016: Cancer
https://www.readbyqxmd.com/read/27705935/circulating-microrna124-3p-microrna9-3p-and-microrna196b-5p-may-be-potential-signatures-for-differential-diagnosis-of-thyroid-nodules
#17
Sui Yu, Xiaoling Liu, Yifei Zhang, Jing Li, Shulin Chen, Haitao Zheng, Ruizhen Reng, Chenglin Zhang, Jian Chen, Li Chen
It is important to develop an effective auxiliary approach to distinguish papillary thyroid carcinoma (PTC) from benign nodules because a considerable proportion cannot be identified by fine-needle aspiration cytology at present, resulting in unnecessary thyroidectomy. Circulating miRNAs are potential biomarkers for differential diagnosis of tumors. We aimed to investigate the dysregulation of circulating miRNAs in PTC and evaluate the diagnostic value for differentiation of PTC from benign nodules. We first assessed the expression of miRNAs in patients with PTC, patients with benign nodules and healthy controls using a miRCURY LNA Array (n = 3 for each group)...
October 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27647872/early-detection-of-biochemically-occult-autonomous-thyroid-nodules
#18
N Brusca, C Virili, M Cellini, S Capriello, L Gargano, R Salvatori, M Centanni, M G Santaguida
OBJECTIVE: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH. This study was aimed at comparing the rate of autonomously functioning areas and their cardiac sequelae in patients with nodular goitre studied with the usual and a novel approach. DESIGN AND METHODS: In total 490 adult outpatients with thyroid nodular goitre, living in a mild iodine-deficient area, were selected in our referral centre for thyroid diseases from 2009 to 2014 on the basis of a suspicion of thyroid functional autonomy...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27633516/women-in-cancer-thematic-review-thyroid-stimulating-hormone-in-thyroid-cancer-does-it-matter
#19
REVIEW
Hannah Nieto, Kristien Boelaert
Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surgery is often required for patients suspected to have malignancy. Serum thyroid-stimulating hormone (TSH) is higher in patients with malignant thyroid nodules than in those with benign disease, and TSH is proportionally increased in more aggressive tumours...
November 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27627674/a-different-perspective-on-evaluating-the-malignancy-rate-of-the-non-diagnostic-category-of-the-bethesda-system-for-reporting-thyroid-cytopathology-a-single-institute-experience-and-review-of-the-literature
#20
Pembegul Gunes, Sule Canberk, Mine Onenerk, Murat Erkan, Nilufer Gursan, Emine Kilinc, Gamze Zeynep Kilicoglu
OBJECTIVE: To determine the malignancy rate in the non-diagnostic (ND) category of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on a different approach in relation to histopathology diagnoses. STUDY DESIGN: All ND fine needle aspirations (FNAs) that were performed under ultrasound guidance by an interventional radiologist with rapid on-site evaluation were included in the study. Slides were reevaluated to identify the cause of inadequacy as "qualitative" or "quantitative...
2016: PloS One
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