keyword
MENU ▼
Read by QxMD icon Read
search

Cervix carcinoma

keyword
https://www.readbyqxmd.com/read/28713771/integrating-hyperthermia-into-modern-radiation-oncology-what-evidence-is-necessary
#1
REVIEW
Jan C Peeken, Peter Vaupel, Stephanie E Combs
Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28711650/role-of-satb2-in-distinguishing-the-site-of-origin-in-glandular-lesions-of-the-bladder-urinary-tract
#2
Giovanna Angela Giannico, Allen M Gown, Jonathan I Epstein, Frank Revetta, Justin A Bishop
The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging due to significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32-33, is a recently described DNA-binding protein involved in osteoblast lineage commitment and expressed in colorectal and appendiceal neoplasms. In this study, we hypothesized that immunohistochemistry for SATB2 may be of value in distinguishing primary adenocarcinoma of the bladder/urinary tract and urothelial carcinoma with glandular differentiation from gastrointestinal and endocervical primaries...
July 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28707541/concurrent-weekly-cisplatin-versus-triweekly-cisplatin-with-radiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-cervix-a-retrospective-analysis-from-a-single-institution
#3
Yoshino Kinjyo, Yutaka Nagai, Takafumi Toita, Wataru Kudaka, Takuro Ariga, Yuko Shimoji, Tadaharu Nakasone, Yusuke Taira, Yoshihisa Arakaki, Tomoko Nakamoto, Akihiko Wakayama, Takuma Ooyama, Hitoshi Maemoto, Joichi Heianna, Yoichi Aoki
OBJECTIVES: To compare patients with cervical cancer who were primarily treated with concurrent chemoradiotherapy (CCRT) using 20 mg/m(2) CCDP for 5 days every 3 weeks with weekly regimens of 40 mg/m(2). METHODS: We retrospectively analyzed 185 patients with Stage IB to IVA squamous cell carcinoma of the cervix who were treated with CCRT between 2005 and 2013 at our hospital. The CCRT regimen consisted of cisplatin at 20 mg/m(2) for 5 days every 3 weeks or 40 mg/m(2) weekly, administered concomitantly with RT...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28700433/data-set-for-the-reporting-of-carcinomas-of-the-cervix-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#4
W Glenn McCluggage, Meagan J Judge, Isabel Alvarado-Cabrero, Máire A Duggan, Lars-Christian Horn, Pei Hui, Jaume Ordi, Christopher N Otis, Kay J Park, Marie Plante, Colin J R Stewart, Edwin K Wiredu, Brian Rous, Lynn Hirschowitz
A comprehensive pathologic report is essential for optimal patient management, cancer staging and prognostication. In many countries, proforma reports are used but the content of these is variable. The International Collaboration on Cancer Reporting is an alliance formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer and the European Society of Pathology, for the purpose of developing standardized, evidence-based reporting data sets for each cancer site...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700431/methods-for-measuring-and-staging-a-uterine-cervical-adenocarcinoma-showing-intracystic-papillary-growth-a-case-report
#5
Hiroshi Yoshida, Shunichi Ikeda, Takafumi Tsukada, Reiko Watanabe, Nobuyoshi Hiraoka, Tomoyasu Kato
Endocervical adenocarcinomas usually demonstrate infiltrative and/or destructive invasion, and the depth and horizontal extent of the invasion are known to have prognostic utility. Here, we report the unusual case of a patient with endocervical adenocarcinoma showing intracystic papillary growth and discuss our methods for measuring and staging this lesion. A 45-yr-old Japanese woman (gravida, 0; para, 0) underwent a cone biopsy for squamous cell carcinoma in situ and atypical glandular cells. Macroscopically, an intracystic tumor (∼7...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28698536/metformin-use-associated-with-lower-risk-of-cancer-in-patients-with-diabetes-mellitus-type-2
#6
Jasna Kusturica, Aida Kulo Ćesić, Edis Gušić, Sanita Maleškić, Maida Rakanović-Todić, Damir Šečić
Aim In order to increase the database related to the antineoplastic potential of metformin, association between the use of metformin and risk of cancer occurence in patients with diabetes mellitus type 2 (DM2) was investigated. Methods In this cross-sectional study, medical records of patients with DM2 were reviewed for cancer occurence. Data on age, body mass index (BMI), alcohol and nicotine consumption, glucose and HbA1c levels, duration of DM2, medication used in the treatment of DM2 and cancer occurence were collected and analyzed...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28686200/cytotoxic-compounds-from-aloe-megalacantha
#7
Negera Abdissa, Sebastian Gohlke, Marcel Frese, Norbert Sewald
Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products-1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)-along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0...
July 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28685798/cyto-colpo-histologic-correlation-about-an-analytical-study-of-120-colposcopies
#8
Olfa Slimani, Riadh Ben Temim, Tahar Makhlouf, Nabil Mathlouthi, Leila Attia
PROBLEM: Cervical cancer is the second gynecological cancer Tunisian women after breast. This is a sexually transmitted disease including the role of HPV has been proven. Cervical cancer screening is possible due to the accessibility of the cervix with a speculum examination and implementation of cervical smear. AIM OF THE WORK: To study the epidemiological and clinical data of patients, analyze the results of the Pap test, colposcopy and cervical biopsy staging are the lesions observed in colposcopy, compare the results of smears, colposcopy and cervical biopsy...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28670843/poorly-differentiated-vaginal-adenocarcinoma-with-aggressive-behavior-pap-smear-findings
#9
José Eleutério, Francisca Margalene Medeiros de Freitas, Denise Nunes Oliveira, David Freitas Moreira, Mirley Sângela Pessoa
Vaginal carcinoma is a rare condition. In this report, we describe a case of a poorly differentiated aggressive adenocarcinoma in a woman with a three month history of vaginal bleeding and a negative Pap smear done six months prior to her consultation. Specular examination showed a normal cervix, but there was a bleeding ulcer (2 cm in diameter) in the upper third of the vagina. Cytology revealed poorly differentiated atypical cells, and the biopsy established a diagnosis of vaginal adenocarcinoma with little differentiation...
July 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28666641/high-grade-squamous-intraepithelial-lesion-hsil-of-the-cervix-with-bizarre-cytological-appearances-pleomorphic-hsil-a-review-of-19-cases
#10
Colin J R Stewart
Cervical high-grade squamous intraepithelial lesions (HSILs) are typically characterised by a proliferation of immature basaloid cells with relatively uniform hyperchromatic nuclei. In this report we describe 19 cases of HSIL exhibiting focal but very marked nuclear atypia often associated with multinucleation ('pleomorphic HSIL'). The bizarre cytological changes mainly involved the basal epithelium particularly in endocervical crypts where the neoplastic cells undermined the native glandular epithelial cells...
June 27, 2017: Pathology
https://www.readbyqxmd.com/read/28662469/molecular-cellular-and-pharmacological-effects-of-platinum-ii-diiodido-complexes-containing-9-deazahypoxanthine-derivatives-a-group-of-broad-spectrum-anticancer-active-agents
#11
Ján Vančo, Zdeněk Trávníček, Radka Křikavová, Jana Gáliková, Zdeněk Dvořák, Marta Chalupová
The platinum(II) iodido complexes 1-5 of the general formula cis-[PtI2(Ln)2], where Ln stands for O-substituted 9-deazahypoxanthine derivatives, were prepared and thoroughly characterized by various techniques, including multinuclear 1D and 2D NMR spectroscopy. The complexes were screened for their anticancer potential in vitro on ten human cancer cell lines, concretely breast adenocarcinoma (MCF7), osteosarcoma (HOS), lung carcinoma (A549), cervix epithelioid carcinoma (HeLa), malignant melanoma (G-361), prostate carcinoma (22Rv1, PC-3), hepatocellular carcinoma (HepG2), ovarian carcinoma (A2780) and cisplatin-resistant ovarian carcinoma (A2780R)...
June 19, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28661577/atypical-uterine-cervix-metastases-from-invasive-lobular-carcinoma-of-the-breast
#12
Carmen Parrilla, Israel Barco, Ares Pedrerol, Antoni Pessarrodona, Nuria Giménez, Antonio García-Fernández
Invasive lobular carcinoma (ILC) of the breast is the second most common histologic subtype of breast cancer, representing 10% of breast cancer occurrences. It differs from invasive ductal carcinoma in its epidemiology, clinical and radiological presentation, associated molecular changes, and the natural course of disease. Often, ILC presents at an advanced stage of onset in postmenopausal women [1]. This article is protected by copyright. All rights reserved.
June 29, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28658872/mri-evaluation-of-local-extent-of-carcinoma-cervix-is-post-contrast-imaging-needed-in-every-case
#13
Joish Upendra Kumar, Ramireddy Harikiran Reddy, Pallavi Sinha, Niveditha Kodali, Vivek Sreekanth
INTRODUCTION: Carcinoma cervix is widely prevalent among women in developing countries. Post contrast Magnetic Resonance Imaging (MRI) utilising spin echo T1 weighted sequence with fat suppression is widely practiced as part of evaluation of carcinoma cervix. However, it is unclear if such post contrast imaging provides any additional information other than adding to the cost of imaging. AIM: To find accuracy of T1 and T2 weighted non contrast MRI protocol in comparison with post contrast spin echo T1 weighted fat suppressed imaging in evaluating the local extent of the carcinoma cervix...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658774/squamous-cell-carcinoma-of-cervix-with-isolated-metastasis-to-ethmoidal-sinus-a-rare-occurrence
#14
Prita Pradhan, Debasis Gochhait, Arun Kumar
Squamous Cell Carcinoma (SCC) of the cervix is a highly prevalent malignancy. Its spread and metastasis is mostly loco-regional. The occurrence of distant extra-pelvic metastases is exceedingly rare, particularly with the involvement of paranasal sinus. This case report documents an unusual presentation of a 45-year-old female diagnosed and treated for squamous cell carcinoma of cervix with metastatic deposits in the ethmoidal sinus without deposits in any intervening foci.
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#15
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28643525/folic-acid-conjugated-nanoliposomes-as-promising-carriers-for-targeted-delivery-of-bleomycin
#16
Mohsen Chiani, Dariush Norouzian, Mohammad Ali Shokrgozar, Kayhan Azadmanesh, Aazam Najmafshar, Mohammad Reza Mehrabi, Azim Akbarzadeh
Targeted drug delivery has received considerable attention due to its key role in improving therapeutic efficacy and reducing the side effects of anticancer drugs. Bleomycin (BLM) is an anticancer antibiotic with short half-life, low therapeutic and high side effects that limit its clinical applications. This study aims to evaluate the anticancer potential of folate-targeted liposomal bleomycin (FL-BLM) and its free-folate form (L-BLM) on two different cancer cell lines including human cervix carcinoma HeLa, and human breast carcinoma MCF-7 cells...
June 23, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28631565/genetic-and-epigenetic-alterations-affecting-park-2-expression-in-cervical-neoplasm-among-north-indian-patients
#17
Afreen Naseem, Zafar Iqbal Bhat, Ponnusamy Kalaiarasan, Bhupender Kumar, Gauri Gandhi, M Moshahid Alam Rizvi
The recent investigation on PARK-2, a putative tumor suppressor gene, has found that it has been altered in multiple human malignancies. However, the clinical impact of PARK-2 alteration in uterine cervix carcinoma has not yet been studied. Therefore, we aimed to examine mutations, promoter hypermethylation, and protein expression of PARK-2 among the North Indian patients and their association with clinical parameters to evaluate the implication of PARK-2 in the genesis of cervical cancer. A total of 168 patient samples were processed for mutational analysis by single-strand conformation polymorphism, sequencing, and further in silico analysis of the identified mutations...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28624547/regioselective-monoalkylation-of-17%C3%AE-estradiol-for-the-synthesis-of-cytotoxic-estrogens
#18
Koen Van Gansbeke, Eirik Johansson Solum, Sandra Liekens, Anders Vik, Trond Vidar Hansen
The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative protocols are still desired. Herein, 11 2-alkylated 17β-estradiol analogs were synthesized in a highly regioselective manner. The products were obtained using a convenient, one pot and high-yielding protocol. The anti-proliferative activity of the compounds was tested in human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human dermal microvascular endothelial (HMEC-1) cells...
June 15, 2017: Steroids
https://www.readbyqxmd.com/read/28610399/sexual-dysfunction-in-females-after-cancer-treatment-an-unresolved-issue
#19
Abhishek Shankar, Neelam Prasad, Shubham Roy, Abhijit Chakraborty, Aalekhya Sharma Biswas, Jaineet Patil, Goura Kishor Rath
Cancer besides being a leading cause of mortality also creates a myriad of morbidities in survivors whether treated or untreated. Among women surviving after gynecological malignancies sexual dysfunction is a morbidity unexplored in Indian context because of cultural barriers. With the increasing proportion of women surviving carcinoma of the cervix, quality of life has become an important clinical issue. Despite the immense distress it causes in patients, sexual dysfunction is neither screened nor treated in Indian scenario...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28603541/cytological-features-of-adenocarcinoma-admixed-with-small-cell-neuroendocrine-carcinoma-of-the-uterine-cervix
#20
Naoshi Shimojo, Yoshifumi S Hirokawa, Kazuki Kanayama, Misao Yoneda, Ryotaro Hashizume, Akinobu Hayashi, Katsunori Uchida, Hiroshi Imai, Yuji Kozuka, Taizo Shiraishi
Adenocarcinoma admixed with neuroendocrine carcinoma of the uterine cervix is a rare malignancy with a poor prognosis, and few reports have described the cytological features of this carcinoma. To characterize the cytological features of this malignancy in cervical smears, we report a case of a 52-year-old Japanese woman with cervical adenocarcinoma admixed with small cell neuroendocrine carcinoma (SCNEC). Cytologically, there were two types of cells with different sizes. The smaller cells formed clusters, which showed a partially Indian file pattern, a high nuclear/cytoplasmic ratio, and hyperchromatic nuclei...
2017: CytoJournal
keyword
keyword
23922
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"