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chronotherapy ambulatory blood pressure

https://read.qxmd.com/read/38197151/clinical-trial-design-for-assessing-hypertension-medications-are-critical-circadian-chronopharmacological-principles-being-taking-into-account
#1
JOURNAL ARTICLE
Ramón C Hermida, Michael H Smolensky, Artemio Mojón, José R Fernández
INTRODUCTION: Clinical hypertension trials typically rely on homeostatic principles, including single time-of-day office blood pressure (BP) measurements (OBPM), rather than circadian chronopharmacological principles, including ambulatory monitoring (ABPM) done around-the-clock to derive the asleep systolic BP (SBP) mean and sleep-time relative SBP decline - jointly the strongest prognosticators of cardiovascular disease (CVD) risk and true definition of hypertension - to qualify participants and assess outcomes...
January 10, 2024: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/38017457/the-effects-of-olmesartan-amlodipine-administered-in-the-morning-or-at-night-on-nocturnal-blood-pressure-reduction-in-chinese-patients-with-mild-moderate-essential-hypertension-oman-trial-study-protocol-for-a-prospective-multicenter-randomized-open-label-clinical
#2
JOURNAL ARTICLE
Mengzhuo Xu, Xin Zhang, Runyu Ye, Xueting Liu, Lirong Sun, Shanshan Jia, Zhipeng Zhang, Xinran Li, Ziqiong Wang, Hang Liao, Rufeng Shi, Kai Liu, Si Wang, Qingtao Meng, Xiaoping Chen
INTRODUCTION: Hypertension increases the risk of cardiovascular disease. Uncontrolled nocturnal blood pressure is prevalent in patients taking antihypertensive medication, with an incidence rate of 30-60%. Although chronotherapy with antihypertensive agents may provide a new direction for effective control of nocturnal blood pressure, the clinical evidence base remains controversial. This research is presently underway to compare the effects of morning and bedtime administration of antihypertensive medication on nocturnal reduction and circadian rhythm of blood pressure in patients with hypertension...
November 28, 2023: Trials
https://read.qxmd.com/read/37955827/non-dipping-blood-pressure-or-nocturnal-hypertension-does-one-matter-more
#3
REVIEW
Amber Tang, Eugene Yang, Joseph E Ebinger
PURPOSE OF REVIEW: Nocturnal hypertension and non-dipping are both associated with increased cardiovascular risk; however, debate remains over which is a better prognosticator of cardiovascular outcomes. This review explores current literature on nocturnal hypertension and non-dipping to assess their relationship to cardiovascular disease and implications for clinical practice. RECENT FINDINGS: While current data remain inconclusive, some suggest that nocturnal hypertension is a more reliable and clinically significant marker of cardiovascular risk than non-dipping status...
January 2024: Current Hypertension Reports
https://read.qxmd.com/read/37906342/clinical-significance-of-nocturnal-hypertension-and-nighttime-blood-pressure-dipping-in-hypertension
#4
REVIEW
Panagiota Anyfanti, Anastasia Malliora, Agapi Chionidou, Konstantinos Mastrogiannis, Antonios Lazaridis, Eugenia Gkaliagkousi
PURPOSE OF REVIEW: This narrative review article aims to discuss more recent evidence, current challenges, and future perspectives regarding the clinical importance of nocturnal hypertension and nighttime blood pressure dipping, with particular reference to diagnosis, prognostic value, and therapeutic approach. RECENT FINDINGS: The importance of nighttime blood pressure and nighttime blood pressure dipping has been demonstrated in decades. Increased nighttime blood pressure has been acknowledged as an unfavorable clinical trait...
October 31, 2023: Current Hypertension Reports
https://read.qxmd.com/read/37212152/timing-of-antihypertensive-drug-therapy-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#5
JOURNAL ARTICLE
Muhammad Haisum Maqsood, Franz H Messerli, Adam H Skolnick, Jonathan D Newman, Jeffrey S Berger, Sripal Bangalore
BACKGROUND: The timing of antihypertensive drugs administration is controversial. The aim was to compare the efficacy of dosing of antihypertensive drugs in the morning versus evening. METHODS: A PubMed, EMBASE, and clinicaltrials.gov databases search for randomized clinical trials of antihypertensive therapies where patients were randomized to morning versus evening dosing. The outcomes were ambulatory blood pressure (BP) parameters (day-time, night-time, and 24/48-hour systolic blood pressure [SBP] and diastolic blood pressure [DBP]) and cardiovascular outcomes...
July 2023: Hypertension
https://read.qxmd.com/read/37107177/assessment-of-oxidative-stress-markers-in-hypertensive-patients-under-the-use-of-renin-angiotensin-aldosterone-blockers
#6
JOURNAL ARTICLE
Nestor Vazquez-Agra, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras
As in other fields, chronotherapy applied to arterial hypertension (AHT) may have implications on oxidative stress. We compared the levels of some redox markers between hypertensive patients with morning and bedtime use of renin-angiotensin-aldosterone system (RAAS) blockers. This was an observational study that included patients older than 18 years with a diagnosis of essential AHT. Blood pressure (BP) figures were measured using twenty-four-hour ambulatory BP monitoring (24-h ABPM). Lipid peroxidation and protein oxidation were assessed using the thiobarbituric acid reactive substances (TBARS) and reduced thiols assays...
March 25, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36625504/the-controversy-of-chronotherapy-emerging-evidence-regarding-bedtime-dosing-of-antihypertensive-medications-in-non-arteritic-anterior-ischemic-optic-neuropathy
#7
JOURNAL ARTICLE
Mary T Labowsky, Joseph F Rizzo
"Blindness upon awakening" occurs in a significant proportion of patients with non-arteritic anterior ischemic optic neuropathy (NAION). This observation has led to a notion that nocturnal hypotension is a significant contributor and, perhaps, the final insult in a multifactorial process leading to the development of NAION, as has been proposed in other ischemic events like strokes, myocardial infarction, and ischemic rest pain. An extension of this concept has led to the recommendation that patients who have experienced NAION avoid taking blood pressure medications at bedtime...
January 2023: Seminars in Ophthalmology
https://read.qxmd.com/read/36109761/masked-nocturnal-hypertension-as-a-result-of-high-prevalence-of-non-dippers-among-apparently-well-controlled-hypertensive-patients-with-type-2-diabetes-mellitus-data-from-a-prospective-study
#8
JOURNAL ARTICLE
Pop Călin, Manea Viorel, Pruna Luchiana, Cosma Mihaela, Pop Lavinia
BACKGROUND: Ambulatory blood pressure monitoring (ABPM) in patients with diabetes mellitus (DM) and hypertension (HTN) show the dipping patterns, identify masked uncontrolled hypertension (MUCH), and demonstrate the effectiveness of the blood pressure (BP) treatment. MUCH is associated with a two-fold higher risk of adverse events. Prevalence in patients with DM is between 13.3 and 66.4%. Our study aims to investigate the prevalence of MUCH and the BP patterns in a population of apparently well-controlled hypertensive patients with type 2 DM (T2DM)...
September 15, 2022: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/36026831/circadian-pattern-in-patients-older-than-75-years-with-hypertension
#9
JOURNAL ARTICLE
Ana M Piera Carbonell, Pilar Rodriguez Anton, Rodrigo Orellana Carrasco, M Jesus Campomanes Suarez, M Ángeles Gavaldá Robert, Juan Eugenio Forcada Lozano, Miguel Ángel Prieto Diaz, Vicente Martin Sanchez, Ángel Díaz Rodríguez, Juan Antonio Divison Garrote, Vicente Pallarés Carratalá
OBJECTIVE: To know the circadian pattern of hypertensive patients older than 75 years, by monitoring blood pressure for 24 hours. DESIGN AND METHOD: Multicenter cross-sectional descriptive study in hypertensive patients aged 75 or over. It was designed for a sample of 117 people, calculated for 8% hypotensive episodes, with a 95% confidence interval, 5% precision, and 25% losses.Non-proportional stratified random sampling was performed, excluding patients with modified antihypertensive treatment in the last month and/or arrhythmias...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/35636476/controversies-in-hypertension-i-the-optimal-assessment-of-blood-pressure-load-and-implications-for-treatment
#10
REVIEW
Edward J Filippone, Andrew J Foy, Gerald V Naccarelli
The most important factor in treating hypertension is assessing an individual patient's true blood pressure load, the cornerstone being research-grade office determination. Office blood pressure should be supplemented with out-of-office measurement, including home and ambulatory monitoring (if available), which we consider complementary and not interchangeable. Controversy remains for initiation of treatment of white coat hypertension, where cardiovascular risk lies between normotension and sustained hypertension; antihypertensive therapy should be considered unless low cardiovascular risk, wherein pressures should be followed for progression to sustained hypertension...
May 28, 2022: American Journal of Medicine
https://read.qxmd.com/read/34912861/dosing-time-matters-nighttime-vs-daytime-administration-of-nifedipine-gastrointestinal-therapeutic-system-gits-or-amlodipine-on-non-dipper-hypertension-a-randomized-controlled-trial-of-narras
#11
JOURNAL ARTICLE
Jing Liu, Xiaofeng Su, Ying Nie, Zhihuan Zeng, Hongyan Chen
Background: Non-dipper hypertension is often characterized by a blunted decrease of nocturnal blood pressure (BP) and is associated with increased risk of target organ damage and cardiovascular (CV) events, while the optimal treatment strategy is yet to be established. This trial was designed to evaluate whether nocturnal BP reduction and arterial stiffness improvement differ from antihypertensive agents and time of administration. Methods: Young and middle-aged adults (18-65 years) with non-dipper hypertension were randomly assigned to nifedipine GITS (gastrointestinal therapeutic system) 30 mg or amlodipine besylate 5 mg once daily for 8 weeks, either taken in the morning or at night...
2021: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/34845793/isolated-nocturnal-hypertension-in-pediatric-kidney-transplant-recipients
#12
REVIEW
Tomáš Seeman, Mairead Pfaff, Christine B Sethna
BACKGROUND: Isolated nocturnal hypertension (INH) is defined as nighttime hypertension in the setting of normal daytime blood pressure (BP), diagnosed by ambulatory BP monitoring (ABPM). METHODS AND RESULTS: Hypertension affects 60%-80% of pediatric kidney transplant recipients, and INH is the most common type of ambulatory hypertension. INH is associated with an increased prevalence of hypertension-mediated target organ damage such as left ventricular hypertrophy in adults and in pediatric kidney transplant recipients...
March 2022: Pediatric Transplantation
https://read.qxmd.com/read/34757122/diagnosis-and-treatment-of-arterial-hypertension-2021
#13
REVIEW
Christian Ott, Roland E Schmieder
In the last 4 years, several evidence-based, national, and international guidelines on the management of arterial hypertension have been published, mostly with concordant recommendations, but in some aspects with discordant opinions. This in-depth review takes these guidelines into account but also addresses several new data of interest. Although being somewhat obvious and simple, accurate blood pressure (BP) measurement with validated devices is the cornerstone of the diagnosis of hypertension, but out-of-office BP measurements are of crucial importance as well...
January 2022: Kidney International
https://read.qxmd.com/read/34592938/relationship-between-renal-function-and-blood-pressure-dipping-status-in-renal-transplant-recipients-a-longitudinal-study
#14
JOURNAL ARTICLE
David A Jaques, Patrick Saudan, Chantal Martinez, Axel Andres, Pierre-Yves Martin, Antoinette Pechere-Bertschi, Belen Ponte
BACKGROUND: Hypertension (HT) is associated with adverse outcomes in kidney transplant (KTX) recipients. Blunting of physiological decrease in nighttime compared to daytime blood pressure (non-dipping status) is frequent in this setting. However, weather non-dipping is independently associated with renal function decline in KTX patients is unknown. METHODS: We retrospectively screened KTX outpatients attending for a routine ambulatory blood pressure monitoring (ABPM) (T1) at a single tertiary hospital...
September 30, 2021: BMC Nephrology
https://read.qxmd.com/read/34190016/elevated-asleep-blood-pressure-and-non-dipper-24h-patterning-best-predict-risk-for-heart-failure-that-can-be-averted-by-bedtime-hypertension-chronotherapy-a-review-of-the-published-literature
#15
REVIEW
Ramón C Hermida, Artemio Mojón, José R Fernández, Ramón G Hermida-Ayala, Juan J Crespo, María T Ríos, Manuel Domínguez-Sardiña, Alfonso Otero, Michael H Smolensky
Several prospective studies consistently report elevated asleep blood pressure (BP) and blunted sleep-time relative systolic BP (SBP) decline (non-dipping) are jointly the most significant prognostic markers of cardiovascular disease (CVD) risk, including heart failure (HF); therefore, they, rather than office BP measurements (OBPM) and ambulatory awake and 24 h BP means, seemingly are the most worthy therapeutic targets for prevention. Published studies of the 24 h BP pattern in HF are sparse in number and of limited sample size...
January 2023: Chronobiology International
https://read.qxmd.com/read/34107831/systematic-review-and-quality-evaluation-of-published-human-ingestion-time-trials-of-blood-pressure-lowering-medications-and-their-combinations
#16
JOURNAL ARTICLE
Ramón C Hermida, Ramón G Hermida-Ayala, Artemio Mojón, Michael H Smolensky, José R Fernández
The pharmacokinetics (PK) - absorption, distribution, metabolism, and elimination - and pharmacodynamics (PD) of hypertension medications can be significantly affected by circadian rhythms. As a consequence, the time when blood pressure (BP) lowering medications are ingested, with reference to the staging of all involved circadian rhythms modulating PK and PD, can affect their duration of action, magnitude of effect on features of the 24 h BP profile, and safety. We conducted a systematic and comprehensive review of published prospective human trials that investigated individual hypertension medications of all classes and their combinations for ingestion-time differences in BP-lowering, safety, patient adherence, and markers of hypertension-associated target organ pathology of the kidney and heart...
October 2021: Chronobiology International
https://read.qxmd.com/read/34088274/chronotherapy-for-morning-blood-pressure-surge-in-hypertensive-patients-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Ziyan Xie, Jiahao Zhang, Chenyu Wang, Xiaowei Yan
BACKGROUND: The morning blood pressure surge (MBPS) is related to an exaggerated risk of cardiovascular diseases and mortality. With increasing attention on circadian change in blood pressure and extensive use of ambulatory blood pressure monitoring (ABPM), chronotherapy that administration of medication according to biological rhythm, is reported to improve cardiovascular outcomes. The aim of this study is to evaluate the influence of chronotherapy of antihypertensive drugs upon MBPS in hypertensive patients...
June 4, 2021: BMC Cardiovascular Disorders
https://read.qxmd.com/read/33994681/effect-of-chronotherapy-of-antihypertensives-in-chronic-kidney-disease-a-randomized-control-trial
#18
JOURNAL ARTICLE
Vaibhav Tiwari, Arpita Ray Chaudhary, Sanjay Dasgupta, Smita Divyaveer, Raju Kumar Sahu, Atanu Pal, Rajib Mondal, Kapiljit Chakravarty, Asit Kumar Mandal, Dipankar Sircar, Rajendra Pandey
INTRODUCTION: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. METHODS: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18-65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM)...
January 2021: Indian Journal of Nephrology
https://read.qxmd.com/read/33571840/extent-of-asleep-blood-pressure-reduction-by-hypertension-medications-is-ingestion-time-dependent-systematic-review-and-meta-analysis-of-published-human-trials
#19
REVIEW
Ramón C Hermida, Artemio Mojón, Ramón G Hermida-Ayala, Michael H Smolensky, José R Fernández
Combined evidence of published prospective outcome trials and meta-analyses substantiate elevated asleep blood pressure (BP) and blunted sleep-time relative BP decline (non-dipping), regardless of wake-time office BP and awake or 24 h BP means, are jointly the most highly significant independent prognostic markers of cardiovascular disease (CVD) risk and worthy therapeutic targets for prevention. Nonetheless, current guidelines continue to recommend the diagnosis of hypertension, when based on ambulatory BP monitoring (ABPM), rely, solely, on either the 24 h or "daytime" BP means...
October 2021: Sleep Medicine Reviews
https://read.qxmd.com/read/33486007/ingestion-time-differences-in-the-pharmacodynamics-of-hypertension-medications-systematic-review-of-human-chronopharmacology-trials
#20
JOURNAL ARTICLE
Ramón C Hermida, Ramón G Hermida-Ayala, Michael H Smolensky, Artemio Mojón, José R Fernández
Pharmacokinetics of hypertension medications is significantly affected by circadian rhythms that influence absorption, distribution, metabolism and elimination. Furthermore, their pharmacodynamics is affected by ingestion-time differences in kinetics and circadian rhythms comprising the biological mechanism of the 24 h blood pressure (BP) pattern. However, hypertension guidelines do not recommend the time to treat patients with medications. We conducted a systematic review of published evidence regarding ingestion-time differences of hypertension medications and their combinations on ambulatory BP-lowering, safety, and markers of target organ pathology...
March 2021: Advanced Drug Delivery Reviews
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