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Stereotactic radiosurgery

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https://www.readbyqxmd.com/read/28727284/technical-note-using-k-means-clustering-to-determine-the-number-and-position-of-isocenters-in-mlc-based-multiple-target-intracranial-radiosurgery
#1
Adam D Yock, Gwe-Ya Kim
PURPOSE: To present the k-means clustering algorithm as a tool to address treatment planning considerations characteristic of stereotactic radiosurgery using a single isocenter for multiple targets. METHODS: For 30 patients treated with stereotactic radiosurgery for multiple brain metastases, the geometric centroids and radii of each met were determined from the treatment planning system. In-house software used this as well as weighted and unweighted versions of the k-means clustering algorithm to group the targets to be treated with a single isocenter, and to position each isocenter...
July 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28725661/assessment-of-stereotactic-radiosurgery-treatment-response-for-brain-metastases-using-mri-based-diffusion-index
#2
Zengai Chen, Jinyan Zu, Lei Li, Xiaojie Lu, Jianming Ni, Jianrong Xu
INTRODUCTION: To investigate the clinical predictive values of the apparent diffusion coefficient (ADC) as a biomarker in radiation response of brain metastases. METHOD: Forty-one patients with brain metastases treated with stereotactic radiosurgery (SRS) were imaged at baseline, one month post SRS, and six months post SRS using diffusion weighted MRI. The mean of ADC for metastases and tumor volume was calculated. A diffusion index (DI) was generated using the sum of 1/ADC among all the voxels in a tumor...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28725518/preferences-and-utilities-for-health-states-after-treatment-of-olfactory-groove-meningioma-endoscopic-versus-open
#3
Christopher M Yao, Alyssa Kahane, Eric Monteiro, Fred Gentili, Gelareh Zadeh, John R de Almeida
Objectives  The purpose of this study is to report health utility scores for patients with olfactory groove meningiomas (OGM) treated with either the standard transcranial approach, or the expanded endonasal endoscopic approach. Design  The time trade-off technique was used to derive health utility scores. Setting  Healthy individuals without skull base tumors were surveyed. Main Outcome Measures  Participants reviewed and rated scenarios describing treatment (endoscopic, open, stereotactic radiation, watchful waiting), remission, recurrence, and complications associated with the management of OGMs...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28725514/gamma-knife-stereotactic-radiosurgery-for-grade-2-meningiomas
#4
Tamer Refaat, Michelle Gentile, Sean Sachdev, Prarthana Dalal, Anish Butala, Stanley Gutiontov, Irene Helenowksi, Plato Lee, Vythialinga Sathiaseelan, Orin Bloch, James Chandler, John A Kalapurakal
Purpose  This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods  In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results  A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28721891/stereotactic-radiosurgery-for-trigeminal-neuralgia-improves-patient-reported-quality-of-life-and-reduces-depression
#5
Rupesh Kotecha, Jacob A Miller, Sujith Modugula, Gene H Barnett, Erin S Murphy, Chandana A Reddy, John H Suh, Gennady Neyman, Andre Machado, Sean Nagel, Samuel T Chao
PURPOSE: To characterize quality-of-life (QOL) outcomes after stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN). METHODS AND MATERIALS: The EuroQOL 5 Dimensions (EQ-5D) and Patient Health Questionnaire 9 (PHQ-9) were prospectively collected before and after SRS for 50 patients with TN. Pain response and treatment-related facial numbness were classified by Barrow Neurological Institute (BNI) scales. Differences in pooled QOL outcomes were tested with paired t tests and sign tests...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721889/clinical-outcomes-of-large-brain-metastases-treated-with-neurosurgical-resection-and-intraoperative-cesium-131-brachytherapy-results-of-a-prospective-trial
#6
A Gabriella Wernicke, Cole B Hirschfeld, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Lucy Nedialkova, Fridon Kulidzhanov, Samuel Trichter, Albert Sabbas, Rohan Ramakrishna, Susan Pannullo, Theodore H Schwartz
PURPOSE: Studies on adjuvant stereotactic radiosurgery to the cavity of resected brain metastases have suggested that larger tumors (>2.0 cm) have greater rates of recurrence and radionecrosis (RN). The present study assessed the effect of permanent low-dose (131)Cs brachytherapy on local control and RN in patients treated for large brain metastases. METHODS AND MATERIALS: After institutional review board approval, 42 patients with 46 metastases ≥2.0 cm in preoperative diameter were accrued to a prospective trial from 2010 to 2015...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721330/truebeam-radiosurgery-for-the-treatment-of-trigeminal-neuralgia-preliminary-results-at-a-single-institution
#7
Mena G Kerolus, Neilayan Sen, Sonal Mayekar, Alistar Templeton, Julius Turian, Aidnag Diaz, Lorenzo Munoz, Richard W Byrne, Sepehr Sani
INTRODUCTION: Radiosurgery is now an established method of satisfactory pain control in patients with trigeminal neuralgia (TN). The Varian Truebeam STx (Varian Medical Systems, Palo Alto, CA) linear accelerator (LINAC) system is an arc-based, frameless stereotactic radiosurgery system used for the treatment of TN. To our knowledge, there has been only one published series of patient histories that documents the use of a frameless LINAC system for the treatment of TN. We describe the treatment parameters, patient outcomes, and complications associated with the treatment of TN...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28721221/pasireotide-successful-treatment-of-a-sparsely-granulated-tumour-in-a-resistant-case-of-acromegaly
#8
W K M G Amarawardena, K D Liyanarachchi, J D C Newell-Price, R J M Ross, D Iacovazzo, M Debono
The granulation pattern of somatotroph adenomas is well known to be associated with differing clinical and biochemical characteristics, and it has been shown that sparsely granulated tumours respond poorly to commonly used somatostatin receptor ligands (SRLs). We report a challenging case of acromegaly with a sparsely granulated tumour resistant to multiple modalities of treatment, ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented with classical features of acromegaly, which was confirmed by an oral glucose tolerance test...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28718316/predictors-of-complications-and-readmission-following-spinal-stereotactic-radiosurgery
#9
Daniel Lubelski, Joseph E Tanenbaum, Taylor E Purvis, Thomas T Bomberger, Courtney Rory Goodwin, Ilya Laufer, Daniel M Sciubba
AIM: to identify preoperative factors associated with morbidity/mortality, hospital length of stay (LOS), 30-day readmission and operation rates following spinal stereotactic radiosurgery (SRS) for spinal tumors. METHODS: The American College of Surgeons National Quality Improvement Program was queried from 2012 to 2014 to identify patients undergoing SRS for spinal tumors. Logistic regression was performed to identify predictors. RESULTS: 2714 patients were identified; 6...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28716071/primary-solitary-plasmacytoma-of-the-liver-successful-treatment-with-fractionated-stereotactic-radiotherapy-cyberknife%C3%A2-a-case-report
#10
Thomas Chalopin, Isabelle Barillot, Jean-Paul Biny, Flavie Arbion, Marie Besson, Maria Santiago-Ribeiro, Eric Piver, Olivier Herault, Emmanuel Gyan, Lotfi Benboubker
BACKGROUND: Solitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia. To the best of our knowledge, very few cases have been reported without systemic disease. We reported a rare case of hepatic solitary plasmacytoma that successfully responded to fractionated stereotactic radiotherapy. CASE PRESENTATION: A 64-year-old white French man had monoclonal gammopathy of the immune globulin G lambda type; he developed a cholestasis and cytolysis with the discovery of a subscapular nodule...
July 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28711480/commissioning-of-small-field-size-radiosurgery-cones-in-a-6-mv-flattening-filter-free-beam
#11
Juan Diego Azcona, Benigno Barbés, Verónica Morán, Javier Burguete
This study aimed to describe the commissioning of small field size radiosurgery cones in a 6-MV flattening filter free (FFF) beam and report our measured values. Four radiosurgery cones of diameters 5, 10, 12.5, and 15 mm supplied by Elekta Medical were commissioned in a 6-MV FFF beam from an Elekta Versa linear accelerator. The extraction of a reference signal for measuring small fields in scanning mode is challenging. A transmission chamber was attached to the lower part of the collimators and used for percentage depth dose (PDD) and profile measurements in scanning mode with a stereotactic diode...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28711334/fully-automated-comprehensive-knowledge-based-planning-for-stereotactic-radiosurgery-preclinical-validation-through-blinded-physician-review
#12
Benjamin P Ziemer, Satomi Shiraishi, Jona A Hattangadi-Gluth, Parag Sanghvi, Kevin Lawrence Moore
PURPOSE: As knowledge-based planning (KBP) attempts to augment and potentially supplant manual treatment planning, it is imperative to ensure any implementation maintains or improves overall plan quality in any disease site. The purpose of this study was to demonstrate the overall quality of KBP-driven automated stereotactic radiosurgery (SRS) treatment planning using blinded physician comparison and determine systematic factors predictive of physician plan preference to guide future KBP refinement...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28711294/clinical-management-and-survival-of-patients-with-central-nervous-system-hemangiopericytoma-in-the-national-cancer-database
#13
Daniel M Trifiletti, Gautam U Mehta, Surbhi Grover, Jason P Sheehan
PURPOSE/OBJECTIVES: Hemangiopericytomas are rare central nervous system (CNS) tumors. We sought to investigate existing clinical management strategies and overall survival (OS) among patients with hemangiopericytomas of the CNS. METHODS/MATERIALS: All patients diagnosed with CNS hemangiopericytoma from 2004 to 2014 in the National Cancer Database were included. Clinical and treatment-related characteristics were analyzed for an association with OS following diagnosis using univariable and multivariable analyses...
July 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28710086/onyx-embolization-prior-to-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-single-center-treatment-algorithm
#14
John D Nerva, Jason Barber, Michael R Levitt, Jason K Rockhill, Danial K Hallam, Basavaraj V Ghodke, Laligam N Sekhar, Louis J Kim
BACKGROUND: Embolization before stereotactic radiosurgery (SRS) for brain arteriovenous malformations (BAVMs) is controversial. OBJECTIVE: To compare clinical and radiographic outcomes in patients undergoing pre-SRS embolization with ethylene copolymer (Onyx) with outcomes in patients undergoing SRS alone. METHODS: Seventy consecutive patients with BAVMs who underwent SRS were retrospectively reviewed. Univariate and multivariate analyses were performed to assess the factors associated with radiographic obliteration and complication...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28709427/investigation-of-irradiated-volume-in-linac-based-brain-hypo-fractionated-stereotactic-radiotherapy
#15
Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss, Young Lee
BACKGROUND: Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to statistically parameterize irradiated volume independently of dose prescription, or margin to determine what spread in achievable irradiated volume one may expect for a given case. METHODS: We defined EXT as the total tissue within the external contour of the patient (including the target) and we defined BMP as the contour of the brain minus PTV...
July 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28708043/reirradiation-spine-stereotactic-body-radiation-therapy-for-spinal-metastases-systematic-review
#16
Sten Myrehaug, Arjun Sahgal, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martinez, Ian Paddick, Jean Régis, Samuel Ryu, Ben Slotman, Antonio De Salles
OBJECTIVE Spinal metastases that recur after conventional palliative radiotherapy have historically been difficult to manage due to concerns of spinal cord toxicity in the retreatment setting. Spine stereotactic body radiation therapy (SBRT), also known as stereotactic radiosurgery, is emerging as an effective and safe means of delivering ablative doses to these recurrent tumors. The authors performed a systematic review of the literature to determine the clinical efficacy and safety of spine SBRT specific to previously irradiated spinal metastases...
July 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28707997/gamma-knife-radiosurgery-for-large-vestibular-schwannomas-greater-than-3-cm-in-diameter
#17
Cheng-Wei Huang, Hsien-Tang Tu, Chun-Yi Chuang, Cheng-Siu Chang, Hsi-Hsien Chou, Ming-Tsung Lee, Chuan-Fu Huang
OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors reviewed their recent experience to assess the potential role of SRS in larger-sized VSs. METHODS Between 2000 and 2014, 35 patients with large VSs, defined as having both a single dimension > 3 cm and a volume > 10 cm(3), underwent Gamma Knife radiosurgery (GKRS)...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28704158/factors-associated-with-occurrence-of-radiation-induced-optic-neuropathy-at-safe-radiation-dosage
#18
Pavle Doroslovački, Madhura A Tamhankar, Grant T Liu, Kenneth S Shindler, Gui-Shuang Ying, Michelle Alonso-Basanta
BACKGROUND: Radiation-induced optic neuropathy (RION) is a rare, and often visually devastating, complication of radiation therapy (RT) near the anterior visual pathways. METHODS: A retrospective case series of patients who developed RION at a tertiary medical center, followed by a case-control study comparing RION cases with matched controls who received RT. RESULTS: Thirteen patients (18 eyes) with RION were identified. Radiation modalities included external beam photon radiation, whole brain radiation, stereotactic radiosurgery, proton beam, and unknown...
July 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28700994/brain-metastasis-from-colorectal-cancer-predictors-and-treatment-outcomes
#19
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Kazuhito Sasaki, Koji Murono, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Toshiaki Watanabe
OBJECTIVE: Difficulties are associated with the management of brain metastasis (BM), which portends a poor prognosis in the treatment of colorectal cancer (CRC). The aim of the present study was to identify risk factors for BM in CRC and evaluate the outcomes of various treatment modalities. METHODS: We retrospectively reviewed data on a total of 2,238 patients with primary CRC who underwent surgical resection at our hospital between 1999 and 2014. Predictive factors for BM and prognostic factors after the diagnosis of BM were examined by univariate and multivariate analyses using Cox proportional hazards models...
July 13, 2017: Oncology
https://www.readbyqxmd.com/read/28691256/clinical-usefulness-of-mlcs-in-robotic-radiosurgery-systems-for-prostate-sbrt
#20
Masashi Tomida, Takeshi Kamomae, Junji Suzuki, Yoichi Ohashi, Yoshiyuki Itoh, Hiroshi Oguchi, Takahito Okuda
Stereotactic body radiation therapy (SBRT) using recently introduced multileaf collimators (MLC) is preferred over circular collimators in the treatment of localized prostate cancer. The objective of this study was to assess the clinical usefulness of MLCs in prostate SBRT by comparing the effectiveness of treatment plans using fixed collimators, variable collimators, and MLCs and by ensuring delivery quality assurance (DQA) for each. For each patient who underwent conventional radiation therapy for localized prostate cancer, mock SBRT plans were created using a fixed collimator, a variable collimator, and an MLC...
July 10, 2017: Journal of Applied Clinical Medical Physics
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