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Stereotactic radiosurgery

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https://www.readbyqxmd.com/read/28325019/frameless-stereotactic-radiosurgery-fsrs-end-to-end-test-with-ebt-xd-gafchromic-film
#1
Yulin Song, Ceferino Obcemea, Boris Mueller, Borys Mychalczak
Frame-based stereotactic radiosurgery (SRS) has been widely used to treat functional disorders, vascular lesions, and primary benign and malignant tumors. Recently, SRS is being increasingly used to treat solitary brain metastases. However, due to its highly invasive nature, frame-based SRS is being gradually replaced by frameless SRS (fSRS). fSRS aims at improving patient comfort and achieving stable patient immobilization with non-invasive means and accurate target localization with image guidance technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#2
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28315230/clinical-outcome-and-molecular-characterization-of-brain-metastases-from-esophageal-and-gastric-cancer-a-systematic-review
#3
REVIEW
Michele Ghidini, Fausto Petrelli, Jens Claus Hahne, Annamaria De Giorgi, Laura Toppo, Claudio Pizzo, Margherita Ratti, Sandro Barni, Rodolfo Passalacqua, Gianluca Tomasello
The aim of the study was to collect the available data on central nervous system (CNS) metastases from esophageal and gastric cancer. A PubMed, EMBASE, SCOPUS, Web of Science, LILACS, Ovid and Cochrane Library search was performed. Thirty-seven studies including 779 patients were considered. Among the data extracted, treatment of tumor and brain metastases (BMs), time to BMs development, number and subsite, extracerebral metastases rate, median overall survival (OS) and prognostic factors were included. For esophageal cancer, the median OS from diagnosis of BMs was 4...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28303210/stereotactic-spine-radiosurgery-review-of-safety-and-efficacy-with-respect-to-dose-and-fractionation
#4
REVIEW
Michael Huo, Arjun Sahgal, David Pryor, Kristin Redmond, Simon Lo, Matthew Foote
BACKGROUND: Stereotactic body radiotherapy (SBRT) is an emerging treatment option for spinal metastases with demonstrated efficacy in the upfront, postoperative, and re-treatment settings, as well as for tumor histologies considered radioresistant. Uncertainty exists regarding the optimal dose and fractionation schedule, with single and multifraction regimens commonly utilized. METHODS: A literature search of the PubMed and Medline databases was conducted to identify papers specific to spine SBRT and the effect of varying dose/fractionation regimens on outcomes...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28300386/evaluation-of-a-surface-imaging-system-s-isocenter-calibration-methods
#5
Adam B Paxton, Ryan P Manger, Todd Pawlicki, Gwe-Ya Kim
AlignRT is a surface imaging system that has been utilized for localizing and tracking patient position during radiotherapy. AlignRT has two calibration procedures that can set the system's isocenter called "Monthly Calibration" (MC) and "Isocentre Calibration" (IC). The MC utilizes a calibration plate. In addition to the calibration plate, the IC utilizes a cubic phantom that is imaged with the linac treatment beam to aid in aligning the AlignRT and treatment-beam isocenters. This work evaluated the effects of misaligning the calibration plate during the calibration process...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28300379/the-spatial-accuracy-of-two-frameless-linear-accelerator-based-systems-for-single-isocenter-multitarget-cranial-radiosurgery
#6
Gary A Ezzell
Single-isocenter, multitarget cranial stereotactic radiosurgery (SRS) is more efficient than using an isocenter for each target, but spatial positioning uncertainties can be magnified at locations away from the isocenter. This study reports on the spatial accuracy of two frameless, linac-based SRS systems for multitarget, single-isocenter SRS as a function of distance from the isocenter. One system uses the ExacTrac platform for image guidance and the other localizes with cone beam computed tomography (CBCT)...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28300370/linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-refractory-trigeminal-neuralgia-detailed-description-of-srs-procedure-and-reported-clinical-outcomes
#7
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Habeeb Saleh, Rajeev Badkul, Hongyu Jiang, Timothy Stepp, Paul Camarata, Fen Wang
PURPOSE/OBJECTIVES: To present our linac-based SRS procedural technique for medically and/or surgically refractory trigeminal neuralgia (TN) treatment and simultaneously report our clinical outcomes. MATERIALS AND METHODS: Twenty-seven refractory TN patients who were treated with a single fraction of 80 Gy to TN. Treatment delivery was performed with a 4 mm cone size using 7-arc arrangement with differential-weighting for Novalis-TX with six MV-SRS (1000 MU/min) beam and minimized dose to the brainstem...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28299759/optimizing-the-benefit-of-cns-radiation-therapy-in-the-pediatric-population-part-2-novel-methods-of-radiation-delivery
#8
REVIEW
Lindsay S Rowe, Andra V Krauze, Holly Ning, Kevin A Camphausen, Aradhana Kaushal
Newer approaches in the field of radiation therapy have raised the bar in the treatment of central nervous system (CNS) malignancies, with recognized advances that have aimed to increase the therapeutic index by improving conformality of the radiation dose to the planned target volume. Beyond these advances, the continued evolution of more effective systems for delivery of radiation to the CNS may offer further benefit not only to adults but also to pediatric patients, a cohort of the population that may be more sensitive to the long-term effects of radiation...
March 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28298046/hypofractionated-stereotactic-radiosurgery-a-new-treatment-strategy-for-giant-cavernous-sinus-hemangiomas
#9
Xin Wang, Huaguang Zhu, Jonathan Knisely, Guanghai Mei, Xiaoxia Liu, Jiazhong Dai, Ying Mao, Li Pan, Zhiyong Qin, Enmin Wang
OBJECTIVE Cavernous sinus hemangiomas (CSHs) are rare benign vascular tumors that arise from the dural venous sinuses lateral to the sella. Stereotactic radiosurgery (SRS) has emerged as a principal alternative to microresection for small- and medium-sized CSHs. Resection is a reasonable option for large (3-4 cm in diameter) and giant (> 4 cm in diameter) CSHs. However, management of giant CSHs remains a challenge for neurosurgeons because of the high rates of morbidity and even death that stem from uncontrollable and massive hemorrhage during surgery...
March 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298033/diffusion-tractography-imaging-guided-frameless-linear-accelerator-stereotactic-radiosurgical-thalamotomy-for-tremor-case-report
#10
Won Kim, Justin Sharim, Stephen Tenn, Tania Kaprealian, Yvette Bordelon, Nzhde Agazaryan, Nader Pouratian
Essential tremor and Parkinson's disease-associated tremor are extremely prevalent within the field of movement disorders. The ventral intermediate (VIM) nucleus of the thalamus has been commonly used as both a neuromodulatory and neuroablative target for the treatment of these forms of tremor. With both deep brain stimulation and Gamma Knife radiosurgery, there is an abundance of literature regarding the surgical planning, targeting, and outcomes of these methodologies. To date, there have been no reports of frameless, linear accelerator (LINAC)-based thalomotomies for tremor...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298026/prospective-comparison-of-long-term-pain-relief-rates-after-first-time-microvascular-decompression-and-stereotactic-radiosurgery-for-trigeminal-neuralgia
#11
Doris D Wang, Kunal P Raygor, Tene A Cage, Mariann M Ward, Sarah Westcott, Nicholas M Barbaro, Edward F Chang
OBJECTIVE Common surgical treatments for trigeminal neuralgia (TN) include microvascular decompression (MVD), stereotactic radiosurgery (SRS), and radiofrequency ablation (RFA). Although the efficacy of each procedure has been described, few studies have directly compared these treatment modalities on pain control for TN. Using a large prospective longitudinal database, the authors aimed to 1) directly compare long-term pain control rates for first-time surgical treatments for idiopathic TN, and 2) identify predictors of pain control...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298016/a-proposed-plan-for-personalized-radiosurgery-in-patients-with-trigeminal-neuralgia
#12
Seyed H Mousavi, Ajay Niranjan, Berkcan Akpinar, Edward A Monaco, Jonathan Cohen, Jagdish Bhatnagar, Yue-Fang Chang, Hideyuki Kano, Sakibul Huq, John C Flickinger, L Dade Lunsford
OBJECTIVE During the last 25 years, more than 100,000 patients worldwide with trigeminal neuralgia (TN) have undergone stereotactic radiosurgery (SRS) with a standard dose of radiation. However, the radiobiological effect of radiation is determined by the amount of energy delivered to the tissue (integral dose [ID] = mean dose × target volume) and is directly associated with the nerve volume. Although the trigeminal nerve volume varies among patients with TN, the clinical impact of this variation in delivered energy is unknown...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298015/toward-the-complete-control-of-brain-metastases-using-surveillance-screening-and-stereotactic-radiosurgery
#13
Amparo Wolf, Svetlana Kvint, Abraham Chachoua, Anna Pavlick, Melissa Wilson, Bernadine Donahue, John G Golfinos, Joshua Silverman, Douglas Kondziolka
OBJECTIVE The incidence of brain metastases is increasing with improved systemic therapies, many of which have a limited impact on intracranial disease. Stereotactic radiosurgery (SRS) is a first-line management option for brain metastases. The purpose of this study was to determine if there is a threshold tumor size below which local control (LC) rates approach 100%, and to relate these findings to the use of routine surveillance brain imaging. METHODS From a prospective registry, 200 patients with 1237 brain metastases were identified who underwent SRS between December 2012 and May 2015...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297351/output-factor-comparison-of-monte-carlo-and-measurement-for-varian-truebeam-6-mv-and-10-mv-flattening-filter-free-stereotactic-radiosurgery-system
#14
Jason Y Cheng, Holly Ning, Barbara C Arora, Ying Zhuge, Robert W Miller
The dose measurements of the small field sizes, such as conical collimators used in stereotactic radiosurgery (SRS), are a significant challenge due to many factors including source occlusion, detector size limitation, and lack of lateral electronic equilibrium. One useful tool in dealing with the small field effect is Monte Carlo (MC) simulation. In this study, we report a comparison of Monte Carlo simulations and measurements of output factors for the Varian SRS system with conical collimators for energies of 6 MV flattening filter-free (6 MV) and 10 MV flattening filter-free (10 MV) on the TrueBeam accelerator...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297348/inverse-treatment-planning-for-spinal-robotic-radiosurgery-an-international-multi-institutional-benchmark-trial
#15
Oliver Blanck, Lei Wang, Wolfgang Baus, Jimm Grimm, Thomas Lacornerie, Joakim Nilsson, Sergii Luchkovskyi, Isabel Palazon Cano, Zhenyu Shou, Myriam Ayadi, Harald Treuer, Romain Viard, Frank-Andre Siebert, Mark K H Chan, Guido Hildebrandt, Jürgen Dunst, Detlef Imhoff, Stefan Wurster, Robert Wolff, Pantaleo Romanelli, Eric Lartigau, Robert Semrau, Scott G Soltys, Achim Schweikard
Stereotactic radiosurgery (SRS) is the accurate, conformal delivery of high-dose radiation to well-defined targets while minimizing normal structure doses via steep dose gradients. While inverse treatment planning (ITP) with computerized optimization algorithms are routine, many aspects of the planning process remain user-dependent. We performed an international, multi-institutional benchmark trial to study planning variability and to analyze preferable ITP practice for spinal robotic radiosurgery. 10 SRS treatment plans were generated for a complex-shaped spinal metastasis with 21 Gy in 3 fractions and tight constraints for spinal cord (V14Gy<2 cc, V18Gy<0...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297343/evaluation-of-the-stability-of-the-stereotactic-leksell-frame-g-in-gamma-knife-radiosurgery
#16
Alvaro Rojas-Villabona, Katherine Miszkiel, Neil Kitchen, Rolf Jäger, Ian Paddick
The purpose of this study was to evaluate the stability of the Leksell Frame G in Gamma Knife radiosurgery (GKR). Forty patients undergoing GKR underwent pretreatment stereotactic MRI for GKR planning and stereotactic CT immediately after GKR. The stereotactic coordinates of four anatomical landmarks (cochlear apertures and the summits of the anterior post of the superior semicircular canals, bilaterally) were measured by two evaluators on two separate occasions in the pretreatment MRI and post-treatment CT scans and the absolute distance between the observations is reported...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297328/a-preplanning-method-for-stereotactic-radiosurgery-to-improve-treatment-workflow
#17
Kang-Hyun Ahn, Naim Ozturk, Brett Smith, Konstantin V Slavin, Matthew Koshy, Bulent Aydogan
Frame-based stereotactic radiosurgery (SRS) requires fixation of an invasive head ring to ensure accurate targeting. Minimizing waiting time with a fixed head ring is important for patient comfort and satisfaction. We report a practical preplanning solution for the Brainlab iPlan treatment planning system that reduces waiting time by expediting the planning process on treatment day. A water-filled anthropomorphic head phantom was used to acquire a surrogate CT image set for preplanning and fused with patient's MRI, which was obtained before the day of treatment...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297327/small-field-detector-correction-factors-effects-of-the-flattening-filter-for-elekta-and-varian-linear-accelerators
#18
Madelaine K Tyler, Paul Z Y Liu, Christopher Lee, David R McKenzie, Natalka Suchowerska
Flattening filter-free (FFF) beams are becoming the preferred beam type for stereotactic radiosurgery (SRS) and stereotactic ablative radiation therapy (SABR), as they enable an increase in dose rate and a decrease in treatment time. This work assesses the effects of the flattening filter on small field output factors for 6 MV beams generated by both Elekta and Varian linear accelerators, and determines differences between detector response in flattened (FF) and FFF beams. Relative output factors were measured with a range of detectors (diodes, ionization chambers, radiochromic film, and microDiamond) and referenced to the relative output factors measured with an air core fiber optic dosimeter (FOD), a scintillation dosimeter developed at Chris O'Brien Lifehouse, Sydney...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297297/investigation-of-dosimetric-differences-between-the-tmr-10-and-convolution-algorithm-for-gamma-knife-stereotactic-radiosurgery
#19
Alvaro Rojas-Villabona, Neil Kitchen, Ian Paddick
Since its inception, doses applied using Gamma Knife Radiosurgery (GKR) have been calculated using a simple TMR algorithm, which assumes the patient's head is of even density, the same as water. This results in a significant approximation of the dose delivered by the Gamma Knife. We investigated how GKR dose calculations varied when using a new convolution algorithm clinically available for GKR planning that takes into account density variations in the head compared with the established calculation algorithm...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296309/characterization-and-evaluation-of-2-5-mv-electronic-portal-imaging-for-accurate-localization-of-intra-and-extracranial-stereotactic-radiosurgery
#20
Kwang Hyun Song, Karen Chin Snyder, Jinkoo Kim, Haisen Li, Wen Ning, Robert Rusnac, Paul Jackson, James Gordon, Salim M Siddiqui, Indrin J Chetty
2.5 MV electronic portal imaging, available on Varian TrueBeam machines, was characterized using various phantoms in this study. Its low-contrast detectability, spatial resolution, and contrast-to-noise ratio (CNR) were compared with those of conventional 6 MV and kV planar imaging. Scatter effect in large patient body was simulated by adding solid water slabs along the beam path. The 2.5 MV imaging mode was also evaluated using clinically acquired images from 24 patients for the sites of brain, head and neck, lung, and abdomen...
July 2016: Journal of Applied Clinical Medical Physics
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