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Stereotactic radiosurgery

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https://www.readbyqxmd.com/read/28640703/integrating-evidence-based-medicine-for-treatment-of-spinal-metastases-into-a-decision-framework-neurologic-oncologic-mechanicals-stability-and-systemic-disease
#1
Ori Barzilai, Ilya Laufer, Yoshiya Yamada, Daniel S Higginson, Adam M Schmitt, Eric Lis, Mark H Bilsky
Patients with cancer are frequently affected by spinal metastases. Treatment is palliative, with the principle goals of pain relief, preservation of neurologic function, and improvement in quality of life. In the past decade, we have witnessed a dramatic change in the treatment paradigms due to the development of improved surgical strategies and systemic and radiation therapy. The most important change to these paradigms has been the integration of spinal stereotactic radiosurgery (SSRS), allowing delivery of tumoricidal radiation doses with sparing of nearby organs at risk...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28633510/in-reply-stereotactic-radiosurgery-for-cystic-vestibular-schwannomas
#2
Michael J Link
No abstract text is available yet for this article.
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28633492/letter-stereotactic-radiosurgery-for-cystic-vestibular-schwannomas
#3
Eduardo de Arnaldo Silva Vellutini, Matheus Fernandes de Oliveira
No abstract text is available yet for this article.
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28626600/distant-brain-recurrence-in-patients-with-five-or-more-newly-diagnosed-brain-metastases-treated-with-focal-stereotactic-radiotherapy-alone
#4
Olivia Claire Barrett, Andrew M McDonald, Jonathan W Thompson, Markus Bredel, Gerald McGwin, Kristen O Riley, John B Fiveash
BACKGROUND: To assess the clinical outcomes in patients with greater than 4 newly diagnosed brain metastases treated with focal stereotactic radiotherapy alone. METHODS: All patients with five or more brain metastases who received focal radiotherapy without whole brain radiation or resection were included in this retrospective analysis. Distant brain failure (DBF), overall survival (OS) and toxicity were reported. RESULTS: Thirty-six patients met inclusion with median clinical follow-up of 6...
2017: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/28625644/treatment-options-for-egfr-mutant-nsclc-with-cns-involvement-can-patients-bloom-with-the-use-of-next-generation-egfr-tkis
#5
REVIEW
Chee-Seng Tan, Byoung Chul Cho, Ross A Soo
With the use of EGFR TKIs, patient survival is now prolonged and as a consequence, a higher chance of development of CNS metastases has been observed during the course of the disease. CNS metastases remains a therapeutically challenging subset of patient to treat owing to the blood-brain barrier (BBB). Prior to routine EGFR mutation testing, surgical resection, stereotactic radiosurgery and/or whole brain radiation therapy (WBRT) were the main treatment options whereas treatment options for patients with leptomeningeal metastases (LM) included intra-thecal chemotherapy, WBRT, and ventriculo-peritoneal shunting...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28621622/glossopharyngeal-neuralgia-treated-by-gamma-knife-radiosurgery-safety-and-efficacy-through-long-term-follow-up
#6
Benjamin Pommier, Gustavo Touzet, Christian Lucas, Maximilien Vermandel, Serge Blond, Nicolas Reyns
OBJECTIVE Glossopharyngeal neuralgia (GPN) is a rare and disabling condition. Just as for trigeminal neuralgia, Gamma Knife radiosurgery (GKRS) is increasingly proposed as a therapeutic option for GPN. The purpose of this study was to assess long-term safety and efficacy of GKRS for this indication. METHODS From 2007 to 2015, 9 patients (4 male and 5 female) underwent a total of 10 GKRS procedures. All of the patients presented with GPN that was refractory to all medical treatment, and all had a long history of pain...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28620750/high-precision-radiotherapy-for-meningiomas-long-term-results-and-patient-reported-outcome-pro
#7
Kerstin A Kessel, Hanna Fischer, Markus Oechnser, Claus Zimmer, Bernhard Meyer, Stephanie E Combs
OBJECTIVE: To evaluate long-term outcome after high-precision radiotherapy (RT) of meningioma patients in terms of survival and side effects. METHODS: We analyzed 275 meningioma cases: 147 low-grade and 43 high-grade meningiomas (WHO II: n = 40, III: n = 3). In all, 85 patients had no pathologically confirmed histology but were determined as low-grade based on multimodal imaging. Surgery was performed in 183 cases. RT was delivered as either radiosurgery (RS, n = 16), fractionated stereotactic radiotherapy (FSRT, n = 241), or intensity-modulated radiation therapy (IMRT, n = 18)...
June 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28616720/quality-of-life-after-whole-brain-radiotherapy-compared-with-radiosurgery-of-the-tumor-bed-results-from-a-randomized-trial
#8
L Kepka, D Tyc-Szczepaniak, K Osowiecka, A Sprawka, B Trąbska-Kluch, B Czeremszynska
BACKGROUND: A recent randomized trial (NCT01535209) demonstrated no difference in neurocognitive function between stereotactic radiotherapy of the tumor bed (SRT-TB) and whole brain radiotherapy (WBRT) in patients with resected single brain metastasis. Patients treated with SRT-TB had lower overall survival compared with the WBRT arm. Here, we compared the health-related quality of life (HRQOL) in patients who received WBRT vs. SRT-TB. METHODS: A self-reported questionnaire was used to assess HRQOL (EORTC QLQ-C30 with the QLQ-BN20 module) before RT, 2 months after RT, and every 3 months thereafter...
June 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28605737/a-nationwide-study-of-stereotactic-radiosurgery-in-a-newly-diagnosed-spine-metastasis-population
#9
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Ung-Kyu Chang, Moon Jun Sohn
BACKGROUND: Stereotactic radiosurgery (SRS), a technique that is emerging as a new treatment option, has been reported to be an effective, noninvasive treatment for spine metastasis patients. OBJECTIVE: This nationwide study aimed to understand the current state of SRS for spine metastasis. METHODS: Patients in this study were first diagnosed with a metastatic spine tumor between 1 July and 31 December 2011. One group (the SRS group) received SRS at least once within 1 year of diagnosis and the other (the non-SRS group) did not receive SRS...
June 13, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28605551/abc-2-method-does-not-accurately-predict-cerebral-arteriovenous-malformation-volume
#10
Christopher Roark, Venu Vadlamudi, Neeraj Chaudhary, Joseph J Gemmete, Joshua Seinfeld, B Gregory Thompson, Aditya S Pandey
BACKGROUND: Stereotactic radiosurgery (SRS) is a treatment option for cerebral arteriovenous malformations (AVMs) to prevent intracranial hemorrhage. The decision to proceed with SRS is usually based on calculated nidal volume. Physicians commonly use the ABC/2 formula, based on digital subtraction angiography (DSA), when counseling patients for SRS. OBJECTIVE: To determine whether AVM volume calculated using the ABC/2 method on DSA is accurate when compared to the exact volume calculated from thin-cut axial sections used for SRS planning...
June 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28605463/stereotactic-radiosurgery-and-hypofractionated-radiotherapy-for-glioblastoma
#11
Jennifer L Shah, Gordon Li, Jenny L Shaffer, Melissa I Azoulay, Iris C Gibbs, Seema Nagpal, Scott G Soltys
Glioblastoma is the most common primary brain tumor in adults. Standard therapy depends on patient age and performance status but principally involves surgical resection followed by a 6-wk course of radiation therapy given concurrently with temozolomide chemotherapy. Despite such treatment, prognosis remains poor, with a median survival of 16 mo. Challenges in achieving local control, maintaining quality of life, and limiting toxicity plague treatment strategies for this disease. Radiotherapy dose intensification through hypofractionation and stereotactic radiosurgery is a promising strategy that has been explored to meet these challenges...
June 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28604998/role-of-radiotherapy-in-the-treatment-of-renal-cell-cancer-updated-and-critical-review
#12
Vincenzo Fusco, Salvatore Parisi, Barbara d'Andrea, Michele Troiano, Maria Antonietta Clemente, Franco Morelli, Rocchina Caivano, Giuseppe Guglielmi
PURPOSE: The growing incidence of renal cell carcinoma (RCC) raises many questions about the management of these patients. The late clinical presentation, the presence of locally advanced or metastatic disease at diagnosis, the difficulty of radical surgical excision, and radioresistance make it one of the more challenging tumors to treat. The primary objective of this article is to propose an updated and critical review of the role of radiotherapy (RT) in the treatment of RCC. METHODS: This literature review is based on data from meta-analyses and randomized, prospective, and retrospective studies...
June 6, 2017: Tumori
https://www.readbyqxmd.com/read/28602418/use-of-stereotactic-radiosurgery-in-elderly-and-very-elderly-patients-with-brain-metastases-to-limit-toxicity-associated-with-whole-brain-radiation-therapy
#13
Linda Chen, Colette Shen, Kristin J Redmond, Brandi R Page, Megan Kummerlowe, Todd Mcnutt, Chetan Bettegowda, Daniele Rigamonti, Michael Lim, Lawrence Kleinberg
PURPOSE: We evaluated the toxicity associated with stereotactic radiosurgery (SRS) and whole brain radiation therapy (WBRT) in elderly and very elderly patients with brain metastases, as the role of SRS in geriatric patients who would traditionally receive WBRT is unclear. METHODS AND MATERIALS: We conducted a retrospective review of elderly patients (aged 70-79 years) and very elderly patients (aged ≥80 years) with brain metastases who underwent RT from 2010 to 2015 at Johns Hopkins Hospital...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28600016/surgical-treatment-of-trigeminal-neuralgia
#14
REVIEW
Sarah K B Bick, Emad N Eskandar
Trigeminal neuralgia is characterized by severe, episodic pain in the trigeminal nerve distribution. Medical therapy is the first line treatment. For patients with refractory pain, a variety of procedures including microvascular decompression, percutaneous radiofrequency rhizotomy, percutaneous glycerol rhizotomy, percutaneous balloon compression, and stereotactic radiosurgery are available. We review the literature and suggest that microvascular decompression remains the gold standard operative therapy. For patients with recurrent pain or who are poor operative candidates, percutaneous radiofrequency rhizotomy offers the best pain response rates and has the advantage of being able to selectively target affected trigeminal divisions...
July 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28598293/stereotactic-body-radiotherapy-for-de-novo-spinal-metastases-systematic-review
#15
Zain A Husain, Arjun Sahgal, Antonio De Salles, Melissa Funaro, Janis Glover, Motohiro Hayashi, Masahiro Hiraoka, Marc Levivier, Lijun Ma, Roberto Martínez-Alvarez, J Ian Paddick, Jean Régis, Ben J Slotman, Samuel Ryu
OBJECTIVE The aim of this systematic review was to provide an objective summary of the published literature pertaining to the use of stereotactic body radiation therapy (SBRT) specific to previously untreated spinal metastases. METHODS The authors performed a systematic review, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, of the literature found in a search of Medline, PubMed, Embase, and the Cochrane Library up to March 2015. The search strategy was limited to publications in the English language...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28595445/sixty-day-mortality-after-stereotactic-radiosurgery-of-brain-metastases-a-forgotten-palliative-treatment-outcome
#16
Federico L Ampil, Anil Nanda, Glenn Mills, Moiz Vora
No abstract text is available yet for this article.
May 9, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28595258/microsurgery-for-recurrent-vestibular-schwannoma-after-previous-gross-total-resection
#17
Avital Perry, Christopher S Graffeo, William R Copeland, Matthew L Carlson, Brian A Neff, Colin L Driscoll, Michael J Link
OBJECTIVE: To present a single-institution experience and supportive systematic literature review examining outcomes after repeat microsurgery for recurrent vestibular schwannoma (VS) following previous gross total resection (GTR). STUDY DESIGN: Retrospective review of prospectively maintained VS database. Systematic literature review. SETTING: Tertiary referral center. PATIENTS: Six proven VS recurrences after primary GTR, treated via repeat microsurgery...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28593112/comparative-neurologic-outcomes-of-salvage-and-definitive-gamma-knife-radiosurgery-for-glomus-jugulare-a-20-year-experience
#18
Daniel V Wakefield, Garrett T Venable, Noam A VanderWalde, L Madison Michael, Jeffery M Sorenson, Jon H Robertson, David Cunninghan, Matthew T Ballo
Objective  This case series investigates management of glomus jugulare (GJ) tumors utilizing definitive and salvage Gamma Knife stereotactic radiosurgery (GKSRS). Methods  A retrospective chart review was performed to collect data. Statistical analysis included patient, tumor, and treatment information. Results  From 1996 to 2013, 17 patients with GJ received GKSRS. Median age was 64 years (range, 27-76). GKSRS was delivered for definitive treatment in eight (47%) and salvage in nine (53%) patients. Median tumor volume was 9...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28591480/laser-interstitial-thermal-therapy-a-first-line-treatment-for-seizures-due-to-hypothalamic-hamartoma
#19
Victor X Du, Shashank V Gandhi, Harold L Rekate, Ashesh D Mehta
Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical management of this lesion have motivated the development of laser interstitial thermal therapy (LITT) as a less invasive treatment approach to the disease. Although overall morbidity and risk would appear to be lower, complications related to LITT therapy have been reported, and the longer-term follow-up that is now possible after initial experience helps address the question of whether LITT provides equivalent efficacy compared to other treatment options...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28589468/optimal-treatment-of-jugular-foramen-schwannomas-long-term-outcome-of-a-multidisciplinary-approach-for-a-series-of-29-cases-in-a-single-institute
#20
Sung Mo Ryu, Jung-Il Lee, Kwan Park, Jung Won Choi, Doo-Sik Kong, Do-Hyun Nam, Han-Shin Jeong, Yang-Sun Cho, Ho Jun Seol
BACKGROUND: The goal of treatment for jugular foramen schwannomas (JFSs) is to achieve complete tumor removal with cranial nerve preservation. However, achieving this goal remains a challenge despite the advances in microsurgical techniques. The aim of this study was to determine optimal treatment strategies for JFSs based on a review of a series of 29 surgical cases in our institute. MATERIALS AND METHODS: Between 1997 and 2013, 29 patients with JFSs underwent surgical treatment by multidisciplinary otoneurosurgical approaches...
June 6, 2017: Acta Neurochirurgica
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