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hormone transition

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https://www.readbyqxmd.com/read/29783047/stroma-cell-derived-factor-1-and-connexins-37-and-43-are-preserved-after-vitrification-and-in-vitro-culture-of-goat-ovarian-cortex
#1
Nathalie Jiatsa Donfack, Kele Amaral Alves, Benner Geraldo Alves, Rebeca Magalhães Pedrosa Rocha, Jamily Bezzera Bruno, Marcelo Bertolini, Regiane Rodrigues Dos Santos, Sheyla Farhaydes Souza Domingues, José Ricardo De Figueiredo, Johan Smitz, Ana Paula Ribeiro Rodrigues
This study aimed to evaluate the follicular morphology and development (follicular activation, cell proliferation, and hormone production), as well as the distribution pattern of Connexins 37 and 43 and SDF-1α after vitrification and in vitro culture of goat ovarian tissue. The study involved four experimental groups: fresh control, vitrified control, fresh culture and vitrified culture. The ovarian fragments were vitrified by a solid surface technique using the Ovarian Tissue Cryosystem and subsequently in vitro cultured for 7 days...
May 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29778271/evaluation-of-environmental-effects-on-reproductive-characteristics-of-mangalarga-marchador-mares-in-a-commercial-embryo-transfer-program
#2
Miguel Alejandro Silva Rua, Celia Raquel Quirino, Ana Cláudia Cerqueira Rodrigues, Mirela Mendes Christo, Marcus Antônio Pessanha Barreto
The objective of this study was to evaluate the environmental effects on embryo recovery rate and pregnancy rate of Mangalarga Marchador mares. The reproductive characteristics of donor and recipient mares were evaluated during five years in Brazilian tropical environment. The mares were used throughout the year and seasons were classified as: October to April (breeding season - BS); May (autumn transition out of the breeding season - ATBS); June to August (non-breeding season - nBS); and September (vernal transition into the breeding season - VTBS)...
May 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29774109/sik2-attenuates-proliferation-and-survival-of-breast-cancer-cells-with-simultaneous-perturbation-of-mapk-and-pi3k-akt-pathways
#3
Neslihan Zohrap, Özge Saatci, Burcak Ozes, Ipek Coban, Hasan Murat Atay, Esra Battaloglu, Özgür Şahin, Kuyas Bugra
Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as a potential tumor suppressor in breast cancer whose expression was reduced in tumor tissues and breast cancer cell lines compared to normal counterparts. In vitro loss- and gain-of-function experiments combined with xenograft studies demonstrated that SIK2-mediated attenuation of proliferation and survival of breast cancer cells with parallel inhibition of both Ras/Erk and PI3K/Akt pathways...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764860/membrane-initiated-estrogen-receptor-signaling-mediates-metabolic-homeostasis-via-central-activation-of-protein-phosphatase-2a
#4
Kazutaka Ueda, Eiki Takimoto, Qing Lu, Pangyen Liu, Nobuaki Fukuma, Yusuke Adachi, Ryo Suzuki, Shengpu Chou, Wendy Baur, Mark J Aronovitz, Andrew S Greenberg, Issei Komuro, Richard H Karas
Women gain weight and their diabetes risk increases as they transition through menopause; these changes can in part be reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen receptor (ER) pathway was employed, and we found that the lack of this pathway precipitated excessive weight gain and glucose intolerance independent of food intake, and that this was accompanied by impaired adaptive thermogenesis and reduced physical activity...
May 15, 2018: Diabetes
https://www.readbyqxmd.com/read/29763890/mir-301a-3p-suppresses-estrogen-signaling-by-directly-inhibiting-esr1-in-er%C3%AE-positive-breast-cancer
#5
Sandra Lettlova, Veronika Brynychova, Jan Blecha, David Vrana, Magdalena Vondrusova, Pavel Soucek, Jaroslav Truksa
BACKGROUND/AIMS: MiRNA-301a-3p is an oncogenic miRNA whose expression is associated with tumor development, metastases and overall poor prognosis. Estrogen receptor α (ERα) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERα is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERα in breast cancer patients indicates invasiveness and poor prognosis...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29762383/starch-tolerance-and-the-short-bowel
#6
Jan de Laffolie, Hassan Y Naim, Silvia Rudloff, Klaus-Peter Zimmer
Short bowel syndrome with intestinal failure is a rare disease with a massive impairment in quality of life, requiring a multidisciplinary team approach to medical, surgical, and nutritional therapy. Current pharmacological and surgical therapeutic options are limited; an important cornerstone is enteral and parenteral nutrition. The changed physiology of carbohydrate digestion plays a major role in the adaptation process and can be a target for specific enteral nutrition interventions. An important prognostic factor is the preservation of at least portions of the colon in continuity with small bowel...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762147/managing-menopause-by-combining-evidence-with-clinical-judgment
#7
Chrisandra Shufelt, Joann Manson
In the United States, nearly 10 million women are currently in the menopause transition and 2.25 million women are 51 years of age, which is the average age of menopause. Approximately 75% of these women will experience vasomotor symptoms such as hot flashes and night sweats. Menopause hormone therapy (HT) remains the most effective treatment for menopausal symptoms, but the decision to use HT is complex and requires balancing the benefits and risks for the individual patient. The decision also requires clinical judgment and shared decision making with the patient...
May 14, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29760101/design-of-an-allosterically-modulated-doxycycline-and-doxorubicin-drug-binding-protein
#8
Karin Schmidt, Bernd R Gardill, Alina Kern, Peter Kirchweger, Michael Börsch, Yves A Muller
The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory mechanisms in biological systems. While the design of ligand-binding sites into proteins remains challenging, this holds even truer for the coupling of a newly engineered binding site to an allosteric mechanism that regulates the ligand affinity. Here it is shown how computational design algorithms enabled the introduction of doxycycline- and doxorubicin-binding sites into the serine proteinase inhibitor (serpin) family member α1-antichymotrypsin...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29757929/transitioning-bodies-the-case-of-self-prescribing-sexual-hormones-in-gender-affirmation-in-individuals-attending-psychiatric-services
#9
Antonio Metastasio, Attilio Negri, Giovanni Martinotti, Ornella Corazza
Self-prescribing of sexual hormones for gender affirmation is a potentially widespread and poorly studied phenomenon that many clinicians are unaware of. The uncontrolled use of hormones poses significant health hazards, which have not been previously reported in the literature. We have collected seven clinical cases in general adult psychiatry settings (both inpatient and outpatients), describing transgender and gender non-conforming individuals' (TGNC) self-prescribing and self-administering hormones bought from the Internet without any medical consultation...
May 14, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29756045/a-knowledge-based-assessment-of-dermatological-care-for-transgender-women
#10
James J Sabra, Celestia X Fang, Roopal V Kundu
Dermatologic care plays an important role in the transitioning process for transgender women, with changes occurring to the skin from hormone therapy (HT) and gender affirming procedures. We sought to identify knowledge gaps in a group of transgender women pertaining to both skin and hair changes during the transitioning process. The study was conducted as a cross-sectional survey. Our results demonstrate potential gaps in knowledge that transgender women have regarding HT and gender affirming procedures.
2018: Transgender Health
https://www.readbyqxmd.com/read/29754304/impact-of-high-deductible-insurance-on-adjuvant-hormonal-therapy-use-in-breast-cancer
#11
Christine Y Lu, Fang Zhang, Anita K Wagner, Larissa Nekhlyudov, Craig C Earle, Matthew Callahan, Robert LeCates, Xin Xu, Dennis Ross-Degnan, J Frank Wharam
OBJECTIVE: High-deductible health plans (HDHPs) have become the predominant commercial health insurance arrangement in the US. HDHPs require substantial out-of-pocket (OOP) costs for most services but often exempt medications from high cost sharing. We examined effects of HDHPs on OOP costs and utilization of adjuvant hormonal therapy (AHT), which are fundamental care for patients with breast cancer. METHODS: This controlled quasi-experimental study used claims data (2003-2012) from a large national health insurer...
May 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29753285/chitin-synthesis-inhibitors-promote-liver-cancer-cell-metastasis-via-interfering-with-hypoxia-inducible-factor-1%C3%AE
#12
Xia Ning, Yue Wang, Wei Yan, Guangke Li, Nan Sang
Chitin synthesis inhibitors (CSIs), as alternatives to conventional insecticides, have been in worldwide demand in recent years. However, little attention has been paid to the potential ecological safety and health risks of CSIs, especially their abilities to interfere with nonsexual hormone receptors such as hypoxia-inducible factor 1α (HIF-1α). In this work, we conducted a systematic study regarding the influence of CSIs on HIF-1α-related liver cancer cell metastasis. The dual-luciferase reporter gene assay revealed that two of fourteen CSIs exhibited dose-response HIF-1α agonistic activities at noncytotoxic concentrations with relative luciferase activity (RLA) values of 25...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29746655/downregulated-angiopoietin-like-peptide-8-production-at-calving-related-to-changes-in-lipid-metabolism-in-dairy-cows
#13
Misato Nakano, Yutaka Suzuki, Satoshi Haga, Eri Yamauchi, Dahye Kim, Koki Nishihara, K Nakajima, Takafumi Gotoh, Seungju Park, Myunggi Baik, Kazuo Katoh, Sanggun Roh
Acute physiological adaptation of lipid metabolism during the postpartum transition period of cows facilitates peripheral metabolic regulation. Hepatokines, which are hormones secreted from hepatocytes, are presumed to play a critical role in systemic metabolic regulation. Angiopoietin-like protein 8 (ANGPTL8) has been identified as a novel hepatokine associated with circulating triglyceride concentrations in mice and humans. However, regulation of ANGPTL8 and its physiological effects are still unknown in cattle...
May 9, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29745750/uplc-ms-ms-assay-development-for-estimation-of-mozavaptan-in-plasma-and-its-pharmacokinetic-study-in-rats
#14
Essam Ezzeldin, Gamal Ae Mostafa, Muzaffar Iqbal, Khalid A Al-Rashood, Yousef Asiri, Toqa El-Nahhas
AIM: Mozavaptan is a nonpeptide vasopressin receptor antagonist approved for the treatment of ectopic antidiuretic hormone secretion syndrome. METHODS & RESULTS: A simple, rapid and fully validated UPLC/MS-MS method was developed for the quantitation of mozavaptan in rat plasma. The chromatographic separation was conducted on an Acquity UPLC BEH™ C18 column with an optimum mobile phase of 10 mM ammonium acetate buffer and 0.1% formic acid in acetonitrile (30:70 v/v) at a flow rate of 0...
May 10, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29740707/sucrose-affects-the-developmental-transition-of-rhizomes-in-oryza-longistaminata
#15
Kanako Bessho-Uehara, Jovano Erris Nugroho, Hirono Kondo, Rosalyn B Angeles-Shim, Motoyuki Ashikari
Oryza longistaminata, the African wild rice, can propagate vegetatively through rhizomes. Rhizomes elongate horizontally underground as sink organs, however, they undergo a developmental transition that shifts their growth to the surface of the ground to become aerial stems. This particular stage is essential for the establishment of new ramets. While several determinants such as abiotic stimuli and plant hormones have been reported as key factors effecting developmental transition in aerial stem, the cause of this phenomenon in rhizome remains elusive...
May 8, 2018: Journal of Plant Research
https://www.readbyqxmd.com/read/29740335/amniotic-fluid-insl3-measured-during-the-critical-time-window-in-human-pregnancy-relates-to-cryptorchidism-hypospadias-and-phthalate-load-a-large-case-control-study
#16
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A G Jönsson, Jens-Peter Bonde, David M Hougaard, Christian H Lindh, Gunnar Toft, Morten S Lindhard, Richard Ivell
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccessibility. We have used a large national biobank of amniotic fluid samples collected at routine amniocentesis to determine the impacts of exogenous endocrine disruptor load on specific fetal biomarkers at this critical time. While adrenal and testicular steroids are highly correlated, they are also mostly positively influenced by increasing phthalate load, represented by the metabolites 7cx-MMeHP and 5cx-MEPP, by perfluorooctane sulfonate (PFOS) exposure, and by smoking, suggesting an adrenal stress response...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29740329/mechanisms-underlying-the-risk-to-develop-drug-addiction-insights-from-studies-in-drosophila-melanogaster
#17
REVIEW
Julia Ryvkin, Assa Bentzur, Shir Zer-Krispil, Galit Shohat-Ophir
The ability to adapt to environmental changes is an essential feature of biological systems, achieved in animals by a coordinated crosstalk between neuronal and hormonal programs that allow rapid and integrated organismal responses. Reward systems play a key role in mediating this adaptation by reinforcing behaviors that enhance immediate survival, such as eating or drinking, or those that ensure long-term survival, such as sexual behavior or caring for offspring. Drugs of abuse co-opt neuronal and molecular pathways that mediate natural rewards, which under certain circumstances can lead to addiction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29736762/developmental-transcriptome-analysis-of-floral-transition-in-rosa-odorata-var-gigantea
#18
Xuelian Guo, Chao Yu, Le Luo, Huihua Wan, Ni Zhen, Yushu Li, Tangren Cheng, Jia Wang, Huitang Pan, Qixiang Zhang
Expression analyses revealed that floral transition of Rosa odorata var. gigantea is mainly regulated by VRN1, COLs, DELLA and KSN, with contributions by the effects of phytohormone and starch metabolism. Seasonal plants utilize changing environmental and developmental cues to control the transition from vegetative growth to flowering at the correct time of year. This study investigated global gene expression profiles at different developmental stages of Rosa odorata var. gigantea by RNA-sequencing, combined with phenotypic characterization and physiological changes...
May 7, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29733815/gene-transcription-ontogeny-of-hypothalamic-pituitary-thyroid-axis-development-in-early-life-stage-fathead-minnow-and-zebrafish
#19
Lucia Vergauwen, Jenna E Cavallin, Gerald T Ankley, Chloé Bars, Isabelle J Gabriëls, Ellen D G Michiels, Krysta R Fitzpatrick, Jelena Periz-Stanacev, Eric C Randolph, Serina L Robinson, Travis W Saari, Anthony L Schroeder, Evelyn Stinckens, Joe Swintek, Steven J Van Cruchten, Evy Verbueken, Daniel L Villeneuve, Dries Knapen
The hypothalamic-pituitary-thyroid (HPT) axis is known to play a crucial role in the development of teleost fish. However, knowledge of endogenous transcription profiles of thyroid-related genes in developing teleosts remains fragmented. We selected two model teleost species, the fathead minnow (Pimephales promelas) and the zebrafish (Danio rerio), to compare the gene transcription ontogeny of the HPT axis. Control organisms were sampled at several time points during embryonic and larval development until 33 days post-fertilization...
May 4, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29732618/the-evolution-of-transgender-surgery
#20
REVIEW
Anna Zurada, Sonja Salandy, Wallisa Roberts, Jerzy Gielecki, Justine Schober, Marios Loukas
An estimated 1.4% of the population worldwide has been diagnosed with Gender Dysphoria, as defined by the Diagnostic and Statistical Manual of Mental Disorders. Gender reassignment, which holistically encompasses psychotherapy, hormonal therapy and genital and nongenital surgeries, is considered the most effective treatment for transgender non-conforming patients afflicted with gender dysphoria. Little research is currently available identifying the psychosocial needs of the transgender population and their access to preventative and primary care during this transitioning process...
May 7, 2018: Clinical Anatomy
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