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https://www.readbyqxmd.com/read/28437219/factors-affecting-sexual-function-in-midlife-women-results-from-the-midlife-women-s-health-study
#1
Rebecca L Smith, Lisa Gallicchio, Jodi A Flaws
OBJECTIVE: The objective of this study was to estimate the importance of risk factors affecting sexual function in sexually active midlife women. MATERIALS AND METHODS: A cohort of 780 women undergoing the menopausal transition was surveyed each year for up to 7 years. Data were collected from sexually active women on sexual function, including frequencies of enjoyment, arousal, orgasm, passion for partner, satisfaction with partner, pain, lack of lubrication, fantasizing, and sexual activity...
February 28, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28435192/effect-of-peripartum-nutritional-management-on-plasma-profile-of-steroid-hormones-metabolites-and-postpartum-fertility-in-buffaloes
#2
R M Kalasariya, A J Dhami, K K Hadiya, D N Borkhatariya, J A Patel
AIM: The aim of this study was to evaluate the influence of peripartum protein and minerals supplementation on plasma profile of steroid hormones, metabolites, and fertility in rural buffaloes. MATERIAL AND METHODS: A total of 85 advanced pregnant (~8 months) pluriparous buffaloes selected at farmers' doorstep in three tribal villages of Middle Gujarat were randomly divided into two groups, viz., control (n=45) and nutrients treatment (40). The buffaloes of treatment group (n=40), in addition to farmers feeding schedule/control, received daily 1...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28434742/endocrine-and-metabolic-changes-in-transition-dairy-cows-are-affected-by-prepartum-infusions-of-a-serotonin-precursor
#3
Lorenzo E Hernández-Castellano, Laura L Hernandez, Helga Sauerwein, Rupert M Bruckmaier
Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28427564/inflammation-in-epileptic-encephalopathies
#4
Oleksii Shandra, Solomon L Moshé, Aristea S Galanopoulou
West syndrome (WS) is an infantile epileptic encephalopathy that manifests with infantile spasms (IS), hypsarrhythmia (in ~60% of infants), and poor neurodevelopmental outcomes. The etiologies of WS can be structural-metabolic pathologies (~60%), genetic (12%-15%), or of unknown origin. The current treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhibitor vigabatrin, while ketogenic diet can be given as add-on treatment in refractory IS...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28426669/a-dynamic-genetic-hormonal-regulatory-network-model-explains-multiple-cellular-behaviors-of-the-root-apical-meristem-of-arabidopsis-thalian
#5
Mónica L García-Gómez, Eugenio Azpeitia, Elena R Álvarez-Buylla
The study of the concerted action of hormones and transcription factors is fundamental to understand cell differentiation and pattern formation during organ development. The root apical meristem of Arabidopsis thaliana is a useful model to address this. It has a stem cell niche near its tip conformed of a quiescent organizer and stem or initial cells around it, then a proliferation domain followed by a transition domain, where cells diminish division rate before transiting to the elongation zone; here, cells grow anisotropically prior to their final differentiation towards the plant base...
April 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28422735/expression-of-embryonal-stem-cell-transcription-factors-in-breast-cancer-oct4-as-an-indicator-for-poor-clinical-outcome-and-tamoxifen-resistance
#6
Jae Moon Gwak, Milim Kim, Hyun Jeong Kim, Min Hye Jang, So Yeon Park
The transcription factors of embryonic stem cells, such as Oct4, Sox2, Nanog, Bmi1, and Klf4, are known to be associated with stemness, epithelial-mesenchymal transition and aggressive tumor behavior. This study was designed to evaluate the clinicopathological significance of their expression in breast cancer. Immunohistochemistry for Oct4, Sox2, Nanog, Bmi1, and Klf4 was performed in 319 cases of invasive breast cancer. The relationship between the expression of these markers and clinicopathologic features of the tumors, including breast cancer stem cell phenotype and epithelial-mesenchymal transition marker expression, and their prognostic value in breast cancer, were analyzed...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421102/ethylene-role-in-plant-growth-development-and-senescence-interaction-with-other-phytohormones
#7
REVIEW
Noushina Iqbal, Nafees A Khan, Antonio Ferrante, Alice Trivellini, Alessandra Francini, M I R Khan
The complex juvenile/maturity transition during a plant's life cycle includes growth, reproduction, and senescence of its fundamental organs: leaves, flowers, and fruits. Growth and senescence of leaves, flowers, and fruits involve several genetic networks where the phytohormone ethylene plays a key role, together with other hormones, integrating different signals and allowing the onset of conditions favorable for stage progression, reproductive success and organ longevity. Changes in ethylene level, its perception, and the hormonal crosstalk directly or indirectly regulate the lifespan of plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28420099/na%C3%A2-%C2%BAi-k%C3%A2-%C2%BAi-dependent-and-independent-signaling-triggered-by-cardiotonic-steroids-facts-and-artifacts
#8
REVIEW
Sergei N Orlov, Elizaveta A Klimanova, Artem M Tverskoi, Elizaveta A Vladychenskaya, Larisa V Smolyaninova, Olga D Lopina
Na⁺,K⁺-ATPase is the only known receptor of cardiotonic steroids (CTS) whose interaction with catalytic α-subunits leads to inhibition of this enzyme. As predicted, CTS affect numerous cellular functions related to the maintenance of the transmembrane gradient of monovalent cations, such as electrical membrane potential, cell volume, transepithelial movement of salt and osmotically-obliged water, symport of Na⁺ with inorganic phosphate, glucose, amino acids, nucleotides, etc. During the last two decades, it was shown that side-by-side with these canonical Na⁺i/K⁺i-dependent cellular responses, long-term exposure to CTS affects transcription, translation, tight junction, cell adhesion and exhibits tissue-specific impact on cell survival and death...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419906/plant-hormone-signaling-in-flowering-an-epigenetic-point-of-view
#9
REVIEW
Gerardo Campos-Rivero, Pedro Osorio-Montalvo, Rafael Sánchez-Borges, Rosa Us-Camas, Fátima Duarte-Aké, Clelia De-la-Peña
Reproduction is one of the most important phases in an organism's lifecycle. In the case of angiosperm plants, flowering provides the major developmental transition from the vegetative to the reproductive stage, and requires genetic and epigenetic reprogramming to ensure the success of seed production. Flowering is regulated by a complex network of genes that integrate multiple environmental cues and endogenous signals so that flowering occurs at the right time; hormone regulation, signaling and homeostasis are very important in this process...
March 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#10
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28415608/collagen-type-iv-alpha-1-col4a1-and-collagen-type-xiii-alpha-1-col13a1-produced-in-cancer-cells-promote-tumor-budding-at-the-invasion-front-in-human-urothelial-carcinoma-of-the-bladder
#11
Makito Miyake, Shunta Hori, Yosuke Morizawa, Yoshihiro Tatsumi, Michihiro Toritsuka, Sayuri Ohnishi, Keiji Shimada, Hideki Furuya, Vedbar S Khadka, Youping Deng, Kenta Ohnishi, Kota Iida, Daisuke Gotoh, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Noboru Konishi, Kiyohide Fujimoto
Current knowledge of the molecular mechanism driving tumor budding is limited. Here, we focused on elucidating the detailed mechanism underlying tumor budding in urothelial cancer of the bladder. Invasive urothelial cancer was pathologically classified into three groups as follows: nodular, trabecular, and infiltrative (tumor budding). Pathohistological analysis of the orthotopic tumor model revealed that human urothelial cancer cell lines MGH-U3, UM-UC-14, and UM-UC-3 displayed typical nodular, trabecular, and infiltrative patterns, respectively...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401496/calcium-intake-bone-mineral-density-and-fragility-fractures-evidence-from-an-italian-outpatient-population
#12
Letizia Vannucci, Laura Masi, Giorgio Gronchi, Caterina Fossi, Anna Maria Carossino, Maria Luisa Brandi
This study was performed in 1000 adult Italian subjects to focus on the effects of dietary calcium intake on bone health. A higher fracture risk appears to be associated with a reduced calcium intake. An adequate daily calcium intake is recommended to counteract osteoporotic fractures. PURPOSE: The principal aim of the present study was to focus on the effects of dietary calcium intake on bone mineral density (BMD) and fragility fractures in a representative sample of an adult Italian outpatient population...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28401024/inhibition-of-stat3-signaling-blocks-obesity-induced-mammary-hyperplasia-in-a-mouse-model
#13
Jeong Won Park, Li Zhao, Mark C Willingham, Sheue-Yann Cheng
Compelling epidemiologic evidence indicates that obesity is a risk factor for human cancers, including breast. However, molecular mechanisms by which obesity could contribute to the development of breast cancer remain unclear. To understand the impact of obesity on breast cancer development, we used a mutant mouse that expresses a mutated thyroid hormone receptor β (denoted as PV) with haplodeficiency of the Pten gene (Thrb(PV/PV)Pten(+/-) mice). We previously showed that adult nulliparous female Thrb(PV/PV)Pten(+/-) mice developed extensive mammary hyperplasia and breast tumors...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28400322/bladder-involvement-in-stage-i-endometriosis
#14
Paula C Brady, Stacey A Missmer, Marc R Laufer
BACKGROUND: Endometriosis-the ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. Bladder involvement, causing dysuria and hematuria, occurs in a very small minority of endometriosis patients. CASE: The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed Stage I endometriosis. Postoperatively, she reported persistent dysuria and passage of tissue in her urine. Cystoscopy showed diffuse erythema; urine cytology revealed glandular and spindle cells suggestive of endometriosis...
April 8, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28399093/-the-differential-diagnosis-and-treatment-of-depressive-disorders-in-climacteric-transition
#15
N A Tyuvina, V V Balabanova, E O Voronina
AIM: To study clinical symptoms of menopause depression, develop differential diagnostic criteria and consider treatment aspects. MATERIAL AND METHODS: One hundred and fifty women, aged 41-65 years, with mental disorders developed in different periods of menopause (perimenopause, menopause and post menopause) were studied. RESULTS AND CONCLUSION: Four types of depression were diagnosed: climacteric (n=46), psychogenic (n=35), endogenic (n=42) and involutional (n=27)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28394252/steroid-hormone-induction-of-temporal-gene-expression-in-drosophila-brain-neuroblasts-generates-neuronal-and-glial-diversity
#16
Mubarak Hussain Syed, Brandon Mark, Chris Q Doe
An important question in neuroscience is how stem cells generate neuronal diversity. During Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express transcription factors that generate neuronal diversity; regulation of the embryonic temporal transcription factor cascade is lineage-intrinsic. In contrast, larval neuroblasts generate longer ~50 division lineages, and currently only one mid-larval molecular transition is known: Chinmo/Imp/Lin-28+ neuroblasts transition to Syncrip+ neuroblasts...
April 10, 2017: ELife
https://www.readbyqxmd.com/read/28387334/sequential-exposure-to-obesogenic-factors-in-females-rats-from-physiological-changes-to-lipid-metabolism-in-liver-and-mesenteric-adipose-tissue
#17
Marta G Novelle, María J Vázquez, Juan R Peinado, Kátia D Martinello, Miguel López, Simon M Luckman, Manuel Tena-Sempere, María M Malagón, Rubén Nogueiras, Carlos Diéguez
During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, exposure to over nutrition, high-energy diet and oestrogen deficiency, are considered as significant obesity risk factors in women. In this study, we assessed how key transitional life events and exposure to different nutrition influence energy homeostasis in a rat model. Specifically, we assessed the sequential exposure to postnatal over nutrition, high-fat diet (HFD) after weaning, followed later by ovariectomy (OVX; as a model of menopause)...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385574/ouabain-promotes-partial-epithelial-to-mesenchymal-transition-emt-changes-in-human-autosomal-dominant-polycystic-kidney-disease-adpkd-cells
#18
Jessica Venugopal, Jeffrey McDermott, Gladis Sanchez, Madhulika Sharma, Leandro Barbosa, Gail A Reif, Darren P Wallace, Gustavo Blanco
The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the ADPKD phenotype includes cell de-differentiation and epithelial to mesenchymal transition (EMT). Here, we determined whether physiological concentrations of ouabain induces EMT in human renal epithelial cells from patients with ADPKD. We found that ADPKD cells respond to ouabain with a decrease in expression of the epithelial marker E-cadherin and increase in the expression of the mesenchymal markers N-cadherin, α smooth muscle actin (αSMA) and collagen-I; and the tight junction protein occludin and claudin-1...
April 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28383176/insight-into-the-remarkable-affinity-and-selectivity-of-the-aminobenzosuberone-scaffold-for-the-m1-aminopeptidases-family-based-on-structure-analysis
#19
Guanya Peng, Alastair G McEwen, Vincent Olieric, Celine Schmitt, Sebastien Albrecht, Jean Cavarelli, Celine Tarnus
Aminopeptidases are ubiquitous hydrolases that cleave the N-terminal residues of proteins and oligopeptides. They are broadly distributed throughout all kingdoms of life and have been implicated in a wide variety of physiological processes, including viral infection, parasite metabolism, protein processing, regulation of peptide hormones, and cancer cell proliferation. Members of the M1 family, also termed gluzincins, are defined by two highly conserved motifs in the catalytic domain: a zinc binding motif, HEXXH-(X18)-E; and an exopeptidase motif, GXMEN...
April 6, 2017: Proteins
https://www.readbyqxmd.com/read/28382093/microrna-222-expression-as-a-predictive-marker-for-tumor-progression-in-hormone-receptor-positive-breast-cancer
#20
Song-Hee Han, Hyun Jeong Kim, Jae Moon Gwak, Mimi Kim, Yul Ri Chung, So Yeon Park
PURPOSE: The microRNA-221/222 (miR-221/222) gene cluster has been reported to be associated with the promotion of epithelial-mesenchymal transition (EMT), downregulation of estrogen receptor-α, and tamoxifen resistance in breast cancer. We studied the expression of miR-222 in human breast cancer samples to analyze its relationship with clinicopathologic features of the tumor, including estrogen receptor status, expression of EMT markers, and clinical outcomes. METHODS: Quantitative real-time polymerase chain reaction was performed to detect the expression of miR-222 in 197 invasive breast cancers...
March 2017: Journal of Breast Cancer
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